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Forthcoming
Kahiga RM, Gatumu JC, Nteere JS. "Sustainability of the implementation of the Preschool physical education curriculum in Nairobi and Nyeri counties.". In: Africa for Research in Comparative Education Society. Kenya Science Campus; Forthcoming.
Gichuki N. Banking Law: Cases and Materials.; Forthcoming.
Geyer. S and Wairire GG, Lombard A, Wairire GG. "A comparative content analysis of South African and Kenyan drug policies from a social development perspective." The Social Work Practitioner-Researcher. Forthcoming.
and Goodluck Charles, Søren Jeppesen PKPK. "Firm-Level Perspectives on State-Business Relations in Africa: The Food processing Sector in Kenya, Tanzania and Zambia." Forum for Development Studies Journal. Forthcoming.
Bunyangha J, Majaliwa MJG, Muthumbi AW, Gichuki NN, Anthony Egeru. "Past and future land use/land cover changes from multi-temporal Landsat imagery in Mpologoma catchment, eastern Uganda." The Egyptian Journal of Remote Sensing and Space Sciences. Forthcoming.
Gona, George, Wambui Kiai, Muiru Ngugi (Eds.). Women in Public Space(s) in Kenya. University of Nairobi & Ford Foundation; Forthcoming.
Submitted
Olsvik O, Mitema ES, Gathuma J, Mirza N. "Acquired tetracycline resistance genes in nosocomial Salmonella typhimurium infection in a Kenyan hospital.". Submitted. AbstractWebsite

Tetracyclines have been among the most widely used antibiotics worldwide. Plasmid-mediated tetracycline resistance among hospital strains of bacteria has continued to rise and of major concern has been the transfer of resistance to pathogenic organisms. Bacteraemia due to hospital acquired S. typhimurium has been a major cause of morbidity at Kenyatta National Hospital (KNH), hence the need to study drug susceptibility pattern of this organism. This study also characterized the tetracycline resistance genes using oligonucleotide probes. Ninety seven S. typhimurium strains isolated from patients at KNH were used. Agar dilution method was used to determine minimum inhibitory concentration (MIC). Plasmids were isolated from each strain and the different plasmid profiles were grouped by their molecular weights into 6 patterns. Out of 97, 87 (88%) strains were resistant. MIC ranged from 1 microgram/ml to 128 micrograms/ml. Genes encoding for tetracycline resistance were located on plasmids of molecular weights 65 MDa, 5.2 or both. Plasmid-encoded antimicrobial resistance is likely to spread to other pathogenic organisms, reduce our ability to treat the infection and increase the cost and duration of treatment.

Jani PG, Gill H, Kotecha V. "Difficult Gallbladder Surgery, Improving Patient Outcomes Through Appropriate Surgical Decisions." East and Central African Journal of Surgery. Submitted;17(1).
Githaiga JW. Evaluation of diagnostic peritoneal lavage and needle paracentesis in the management of penetrating and blunt abdominal trauma, at Kenyatta National Hospital.; Submitted. Abstract

OBJECTIVE: To determine the accuracy and sensitivity of diagnostic peritoneal lavage in the assessment of intra-abdominal injury using the dipstick method. DESIGN: Prospective study, involving the performance of diagnostic peritoneal lavage in the out patient department and surgical wards prior to surgical intervention. SETTING: Kenyatta National Hospital-General Surgical and Orthopaedic wards and outpatient department. The study was conducted over a duration of six months, starting from January 1995 to July 1995. RESULTS: Ninety six patients with penetrating (68) and blunt (28) abdominal trauma underwent diagnostic peritoneal lavage as evaluation of the severity of abdominal trauma. Dipstick (combur 9 strips) was used to evaluate lavage effluent for red blood cells, white blood cells, protein and bilirubin. Forty three patients had positive diagnostic peritoneal lavage (DPL) results, of which 40 (93%) had positive findings at laparatomy and three (7%) had negative findings at laparatomy. The remaining 53 patients had negative DPL results and were managed conservatively. One patient with a negative DPL result became symptomatic and had a positive laparatomy. Conservatively managed patients were discharged after 24 hours observations without any complications. DPL had an accuracy and sensitivity of 93% and specificity of 98%. CONCLUSION: Diagnostic peritoneal lavage is a cheap, safe and reliable method for assessment of abdominal trauma. The method is easy to perform by trained junior doctors in the OPD, or as a bedside procedure. Use of this method reduced negative laparotomy rate from 50% to 6.9% and average duration of stay from 6.5 days to 1.9 days. This method is recommended as a basic tool in the assessment of abdominal trauma patients

Gathigi GW. "FM Radio Broadcasting in Local Languages Triggering Rural Empowerment in Kenya." Jahazi Arts and Culture Journal. Submitted.
Mungai NN, Kibwage IO, Mwangi JW, Guantai AN, Njogu PM, Ongarora DSB. "Isolation, Characterization and Antiplasmodial Activity of Phytochemical Constituents from Monanthotaxis parvifolia (Oliv.) Verdc ssp. kenyensis Verdc." East and Central African Journal of Pharmaceutical Sciences. Submitted;17:87-93.abstract__mungai_et_al._2014.pdf
Weinstein, A. EORTALWAGMCSS, Ebinger, C. ORTALWAGMSSC, Oliva, S. RTALWAGMSCM, Roecker, S. TALWAGMCMC, Tiberi, C. ALWAGMMCE, Aman, M. LWAGMCEJ, Lambert, C. WAGMEJS, Witkin, E. AGMJS, Albaric, J. GMS, Gautier, S. M, Muzuka, A. MKHI-KMFPMRGGR, Mulibo, G. KG, Kianji, G., Hadfield, R. I-KMFPMRFMR, Illsley-Kemp, F. MFPMRMRS, Msabi, M. FPMRRSJ, Ferdinand, R. PMRSJ, Peyrat, S. MRJ, Muirhead, J. R, Rodzianko, A., Fischer T. "Magmatic Co2 assisted rifitng in East Africa : seismicity of the Magadi-Natron-Manyara basins, Africa. Submitted to Tectonics." tectonics. Submitted.
Parton WJ, Scurlock JMO, Ojima DS, Gilmanov TG, Scholes RJ, Schimel DS, Kinyamario JI. "Observations and modeling of biomass and soil organic matter dynamics for the grassland biome worldwide.". Submitted. AbstractObservations and modeling of biomass and soil organic matter dynamics for the grassland biome worldwide

Century is a model of terrestrial biogeochemistry based on relationships between climate, human management (fire, grazing), soil properties, plant productivity, and decomposition. The grassland version of the Century model was tested using observed data from 11 temperate and tropical grasslands around the world. The results show that soil C and N levels can be simulated to within ±25% of the observed values (100 and 75% of the time, respectively) for a diverse set of soils. Peak live biomass and plant production can be simulated within ± 25% of the observed values (57 and 60% of the time, respectively) for burned, fertilized, and irrigated grassland sites where precipitation ranged from 22 to over 150 cm. Live biomass can be generally predicted to within ±50% of the observed values (57% of the time). The model underestimated the live biomass in extremely high plant production years at two of the Russian sites. A comparison of Century model results with statistical models showed that the Century model had slightly higher r2 values than the statistical models. Data and calibrated model results from this study are useful for analysis and description of grassland carbon dynamics, and as a reference point for testing more physiologically based models prediction's of net primary production and biomass. Results indicate that prediction of plant and soil organic matter (C and N) dynamics requires knowledge of climate, soil texture, and N inputs.

Muia JMK, Kariuki JN, Mbugua PN, Gachuiri CK, Lukibisi LB, Ayako WO, Ngunjiri WV. "Smallholder dairy production in high altitude Nyandarua milk-shed in Kenya: Status, challenges and opportunities.". Submitted. AbstractWebsite

A stratified sampling method was used to select 156 dairying households from representative Divisions in Nyandarua County. The stratification was based on cattle grazing systems (CGS) and agro-ecological zones (AEZs) across the Divisions. The objectives of the study were to assess status of smallholder dairy cattle production in relationship to CGS and AEZ, major challenges facing smallholder dairy production, and the opportunities for improvement. Data collected included the characteristics of the farm, family, farmer, feeds and feeding, dairy cattle and their performance, milk uses and markets, and the dairy production services. The information on the challenges facing dairy production and the opportunities for improvement was obtained from discussions with livestock extension workers, dairy co-operatives, milk processors, and from secondary sources. The present results indicated that the average farm size was 3.5 Ha and 41, 38, and 44% of the households fed dairy stock with improved fodders, grass hay, and concentrate supplements, respectively. Among the households, about 44, 38 and 32% had access to artificial insemination (AI), extension, and all weather roads services, respectively. Households keeping crosses of the dairy breeds were 59% while the average herd size was 5.3 heads consisting of 40% cows in milk. The average calf live-weight gain was 322g/ day and milk yield per cow was 8.4kg/day. About 65% of the milk was marketed at an average price of 15.00 KES/kg, equivalent to 0.205 US$/kg. As the levels of dairy intensification increased, there were significant increase in milk production per hectare and decrease in calf live-weight gains (P<0.05). On the other hand, as the level of agricultural potential increased, there were significant decreases in milk production and marketed milk per farm (P<0.05). It was concluded that smallholder dairy cattle production was below the potential for Nyandarua County and was influenced by the CGS and AEZs. The major challenges in smallholder dairy production included poor road network and milk marketing, high costs and inaccessibility of dairy production inputs and support services, inappropriate dairy production technologies, and limited value addition of milk.

Gitao CG, Bebora L. "Subclinical mastitis affecting hygienic quality of marketed camel milk from North - Eastern Province, Kenya.". Submitted. Abstractsubclinical_mastitis_affecting_hygienic_quality_of.pdfWebsite

North Eastern Province, camel is the dominant livestock; it provides subsistence to many people especially during the frequent droughts when other animals either die or are unthrifty. This is beca use camel is highly suited for hot environments. In this region, camels number approximately 3 million and are the main producers of milk for the residents, who are mainly of Somali origin, and are pastoralists. Currentl y, the milk is also sold in Nairobi and other far places; and there is a fast growing demand for it. This has necessitated examination of the milk quality, in response to food safety awareness, especially noting that some of the bacteria causing subclinical mastitis can cause disease in humans. This study was carried out to establish the hygienic quality of camel milk from this area, zeroing down to 2 districts, Garissa and Wajir. T hree hundred and eighty four bulk camel milk samples were collected in volumes of 200 to 300 ml. They wer e transport ed to the laboratory in cold/ice boxes and bacterial isolation and characterization done not later than 24 h after arrival at the laboratory. Before culturing, the milk samples were screened using Ca lifornia Mastitis Test (CMT); samples testing positive (a n indication of subclinical mastitis) were then subjected to bacteriological investigation, using standard methods. Results of this study have shown that subclin ical mastitis is prevalent in dromedary camels of Garissa and Wajir districts of North Eastern province of Kenya, and that Gram positive cocci ( Staphylococcus and Streptococcus) are the dominant mastitis pathogens isolated. Other isolated bacteria included Klebsiella/Enterobacter, E scherichia coli and Bacillus. The positive correlation of CMT with the presen ce of mastitis pathogens in camel milk showed that CMT is a useful screening test in the detection of subclinical mastitis in camels; it is thus a useful tool for farm ers, aiding them in picking the affected animals, segregating and treating them. The resu lts also contribute towards coming up with respective control measures so as to keep camel milk fresh for longer periods and als o make it safe for human consumption.

Okeng'o GO, Malo JO, Awuor JB, Genga RO. "Testing Structure Formation in the Universe via Coupled Matter Fluids.". Submitted.
Gripenberg U, Saarinen I, Bwibo NO, Oduori ML, Grayburn JA, Awori NW, Wasunna AE, Kinuthia DM. "Two true hermaphrodites with XX chromosomes.". Submitted.
Githigia SM, Njagi LW, Mbuthia PG, Gathumbi PK, Cooper ME, Cooper JE. "veterinary forensic medicine: an emerging and important discipline.". Submitted.Website
Adwok JA, Githaiga JW. "Wandering spleen presenting as a right hypochondrial mass and intestinal obstruction.". Submitted. Abstract

This is a case report of a 23 year old multiparous woman who presented with intestinal obstruction and a right hypochondrial mass. Laparatomy revealed an infarcted 1.4 Kg spleen in the right lumbar region compressing the ascending colon. There was also ileal volvulus around the splenic pedicle. This is probably the first documented case of wandering spleen in the right hypochondrium, presenting as right large bowel obstruction, to be reported in our region. Wandering spleen is a rare condition, often asymptomatic, but may present as an acute abdomen. Pre-operative diagnosis is difficult and rarely made. Laboratory tests are seldom useful, but imaging studies do assist. Up to 1971 only 350 cases had been reported in the western literature. Review of English literature from 1900 to 1991 reported only 51 cases in children. In our region 11 cases were reported in Uganda between 1968 and 1971. No other literature is available from our region. Clinical presentation, aetiology, investigation, and management of wandering spleen is discussed

Githaiga JW, Adwok JA. "Wandering spleen presenting as a right hypochondrial mass and intestinal obstruction.". Submitted. Abstract

This is a case report of a 23 year old multiparous woman who presented with intestinal obstruction and a right hypochondrial mass. Laparatomy revealed an infarcted 1.4 Kg spleen in the right lumbar region compressing the ascending colon. There was also ileal volvulus around the splenic pedicle. This is probably the first documented case of wandering spleen in the right hypochondrium, presenting as right large bowel obstruction, to be reported in our region. Wandering spleen is a rare condition, often asymptomatic, but may present as an acute abdomen. Pre-operative diagnosis is difficult and rarely made. Laboratory tests are seldom useful, but imaging studies do assist. Up to 1971 only 350 cases had been reported in the western literature. Review of English literature from 1900 to 1991 reported only 51 cases in children. In our region 11 cases were reported in Uganda between 1968 and 1971. No other literature is available from our region. Clinical presentation, aetiology, investigation, and management of wandering spleen is discussed

Seth D. Goldstein, MD1; Dominic Papandria MD2; ALMDMPH3;, ani Georges Azzies, MD4; Eric Borgstein FRCS5; CMD6; SFMDMPH7; PJMBCB;RG, Mary Klingensmith, MD9; Mohamed Labib10 FLMD; MMMD11; EO’F12; RRMDMPH7;A, Fizan Abdullah, MD PD1. “Innovative approaches to educating the global surgical worldforce: A pilot camparison of online curricula for use in low and middle income countries”.; Submitted.
Muchane M, Githiru M. "The birds of Gongoni Forest Reserve South Coast, Kenya." SCOPUS. Submitted:1. Abstract
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Mwangi E, Gatari M. "Curriculum Development of a Nuclear Engineering Course for Human Resources Enhancement in the Kenya Nuclear Energy Program." kns.org. Submitted. AbstractWebsite

In order to increase generation capacity from reliable sources, Kenya has proposed to install a low-end nuclear power plant to supplement the envisaged short fall. At the moment, most of the power is generated from hydro and geothermal sources. Although an expansion of …

NYAMBANE MN, GATARI MJ, Githiri JG,... "Energy and Exergy Analysis Concepts: Modelling of Olkaria II Geothermal Power Plant in Kenya." promitheasnet.kepa.uoa.gr. Submitted. AbstractWebsite

Condensers of geothermal power plants need to operate at low pressures to ensure optimal use of energy resources. To optimize the steam condensation process cooling water temperature is varied to determine the value that gives a higher condenser efficiency …

Maina DM, Gatari MM, Bartilol SK, Nguli MK. "ESSENTIAL TRACE METALS IN SELECTED MAIZE FLOUR BRANDS CONSUMED IN NAIROBI, KENYA: APPLICATION OF TXRF." imeko.org. Submitted. AbstractWebsite

Human beings obtain their essential trace metals form their diets. The objective of this study was to determine the Mn, Fe, Cu, and Zn concentration levels in maize flour and based on the results estimate the daily intake of these essential metals through consumption of Ugali; …

Kairu WM, Gatari MM, MUIA ML, Mumenya SW,... "Health monitoring of concrete using rebar-guided ultrasound." pdfs.semanticscholar.org. Submitted. AbstractWebsite

Concrete is one of the commonly used materials worldwide in the construction industry due to its durability [1]. Civil infrastructures such as power plants, bridges and large buildings are typically built using concrete. It is typically composed of aggregate, sand, cement, water as …

G. PROFSIMIYUVINCENT. "Human Settlement in South Nyanza.". In: Procedings of a Conference sponsored by the Swedish agency for Research co-operation with Development Countries (SAREC) and organised by the Centre for Archaelogy and Antiquties, University of Tananarive Madagascar, SAREC, Sweden.; Submitted. Abstract

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BIRIR JK, GATARI MJ, RAJAGOPAL P, MUIA ML. "Improved Resolution in Guided Wave Testing." pdfs.semanticscholar.org. Submitted. AbstractWebsite

Guided wave technology is today widely used for long range ultrasonic testing, especially for pipeline, tank floor and rail track condition monitoring. In pipeline inspection for instance guided wave testing (GWT) offers advantages over other mainstream technologies such as …

G PROFGATEIDAVID. "J E Sanderson, E G Olsen, and D Gatei.Peripartum heart disease: an endomyocardial biopsy study.". In: Br Heart J. 56(3): 285. RIVERBRROKS COMMUNICATIONS; Submitted. Abstract
Endomyocardial biopsies were performed in 11 African women in Nairobi who presented with the clinical features of peripartum cardiomyopathy. The samples were studied by light and electron microscopy. In five patients there was evidence of a "healing myocarditis", that is the presence of a mild inflammatory cell infiltration within the myocardium with foci of necrosis and variable amounts of hypertrophy and fibrosis. Of the nine patients who were followed up, three out of four with myocarditis had persistent heart failure and four out of five without myocarditis improved. Peripheral blood T lymphocyte cell subsets were measured in nine patients by means of monoclonal antibodies. A high helper:suppressor T cell ratio was found in three patients. Almost half of this group of patients with peripartum cardiomyopathy had myocarditis in their biopsy specimens. The myocarditis may have been due to an inappropriate immunological reaction in some patients.
G. PROFSIMIYUVINCENT. "Les Classes Sociales en Afrique de Iquest Pre-Coloniale in He-CHI Revue dEtudes Francaises de Iuniversite de Nairobi.". In: P. 47-53 Editorship: African in Time Perspective. Weekly Radio Talks on African History, V.O.K.; Submitted. Abstract

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G PROFKARANJAJOSEPH, OTIENO DRODAWAFRANCISXAVIER. "NJOROGE W, NDAVI PM, KARANJA JG, MATI JKG. The incidence of cervical extropion among women on contraceptive methods in two periurban areas in Nairobi. J. Obst. Gynaec. East Cent. Afr. 15:00-00.". In: J. Obst. Gynaec. East Cent. Afr. 15:00-00. EM Ngatia, LW Gathece, FG Macigo, TK Mulli, LN Mutara, EG Wagaiyu.; Submitted. Abstract
PIP: This research report studies several biochemical and histochemical aspects of cervical carcinoma and explores their use in follow-up of patients undergoing radiotherapy. Material came from 19 patients with invasive cervical carcinoma admitted to Kenyatta National Hospital. A control group consisted of 20 women matched for age who attended clinics at the hospital but were not suffering from any malignant disease; control tissue for histological examination was obtained from 3 women who had undergone hysterectomy for uterine fibroids. Biochemical assays for alkaline and acid phosphatases in patients with cervical carcinoma show an increase in alkaline phosphatase in carcinomatous tissue (35.7 umoles/hr/mg) as opposed to normal tissue (7.2). Acid phosphatase values were only moderately raised. Assays of the same enzymes in blood showed a less marked difference between patients and controls (ranges of 7.5-20.8 and 3-14, respectively). When examined histochemically, increased alkaline phosphatase activity was observed in connective tissue, epithelium of the glands and blood capillaries of tumor tissue. 1 section containing normal tissue bordering carcinomatous tissue demonstrated normal alkaline phosphatase activity in the normal tissue and increased activity in the tumor tissue. In summary, there is increased enzyme activity around the tumor areas, but values for serum levels show an overlap of normal and abnormal cases and are therefore not predictive. Results demonstrate a clear difference in activities of these enzymes in carcinomatous tissue and normal tissue, which may be of value in follow-up care.
MWANIA MJM, GATARI MJ, MAINA MDM, KINYUA R. "Recycled waste plastics composite: Possible construction material for wind turbine blades." promitheasnet.kepa.uoa.gr. Submitted. AbstractWebsite

Electrical power supply in Sub Saharan Africa (SSA) is expensive and very low, and most families have no chance of accessing clean lighting and cooking power. Off grid systems are the best viable solution in SSA and wind energy has a potential. However, the components …

de la Mata M, Magen C, Gazquez J, Utama MIB, Heiss M, Lopatin S, Furtmayr F, Fernández-Rojas CJ, Peng B, Morante JR, others. "Supplementary information of the manuscript entitled.". Submitted. Abstract
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ASIAGO DORCAH, GATHII ALICE, Ngesu LM, Gunga SO, Gakuru A, Kahigi C, Nyaga VK, Oundo MB, Kamoyo JM, ADEGBORO JS, others. "TEACHERS’PERCEPTIONS OF PERFORMANCE APPRAISAL PRACTICES IN PUBLIC SECONDARY SCHOOLS IN LIMURU DISTRICT.". Submitted. Abstract
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In Press
2022
Vannevel V, Vogel JP, Pattinson RC, Adanu R, Charantimath U, Goudar SS, Gwako G, Kavi A, Maya E, Osoti A, Pujar Y, Qureshi ZP, Rulisa S, Botha T, Oladapo OT. "Antenatal Doppler screening for fetuses at risk of adverse outcomes: a multicountry cohort study of the prevalence of abnormal resistance index in low-risk pregnant women." BMJ Open. 2022;12(3):e053622. Abstract

Few interventions exist to address the high burden of stillbirths in apparently healthy pregnant women in low- and middle-income countries (LMICs). To establish whether a trial on the impact of routine Doppler screening in a low-risk obstetric population is warranted, we determined the prevalence of abnormal fetal umbilical artery resistance indices among low-risk pregnant women using a low-cost Doppler device in five LMICs.

QURESHI ZAHIDA, Jamner A, Filippi V, Gwako G, Osoti A, Mehrtash H, Baguiya A, Bello FA, Compaoré R, Gadama L, Kim CR, Msusa AT, Tunçalp Ӧ, Calvert C. "Level and determinants of contraceptive uptake among women attending facilities with abortion-related complications in East and Southern Africa." Int J Gynaecol Obstet. 2022;156 Suppl 1:27-35. Abstract

To investigate the level and determinants of nonreceipt of contraception among women admitted to facilities with abortion-related complications in East and Southern Africa.

Githiora-Murimi YW, Owuor MA, Abila R, Olago D, Oriaso S. "Integrating stakeholder preferences into ecosystem services mapping in Yala wetland, Kenya." Ecosystems and PeopleEcosystems and People. 2022;18(1):146-163. AbstractWebsite
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Plisnier P-D, Kayanda R, MacIntyre S, Obiero K, Okello W, Vodacek A, Cocquyt C, Abegaz H, Achieng A, Akonkwa B, Albrecht C, Balagizi C, Barasa J, Abel Bashonga R, Bashonga Bishobibiri A, Bootsma H, Borges AV, Chavula G, Dadi T, De Keyzer ELR, Doran PJ, Gabagambi N, Gatare R, Gemmell A, Getahun A, Haambiya LH, Higgins SN, Hyangya BL, Irvine K, Isumbisho M, Jonasse C, Katongo C, Katsev S, Keyombe J, Kimirei I, Kisekelwa T, Kishe M, Otoung A. Koding S, Kolding J, Kraemer BM, Limbu P, Lomodei E, Mahongo SB, Malala J, Mbabazi S, Masilya PM, McCandless M, Medard M, Migeni Ajode Z, Mrosso HD, Mudakikwa ER, Mulimbwa N'sibula, Mushagalusa Déo, Muvundja FA, Nankabirwa A, Nahimana D, Ngatunga BP, Ngochera M, Nicholson S, Nshombo M, Ntakimazi G, Nyamweya C, Ikwaput Nyeko J, Olago D, Olbamo T, O'Reilly CM, Pasche N, Phiri H, Raasakka N, Salyani A, Sibomana C, Silsbe GM, Smith S, Sterner RW, Thiery W, Tuyisenge J, Van der Knaap M, Van Steenberge M, van Zwieten PAM, Verheyen E, Wakjira M, Walakira J, Ndeo Wembo O, Lawrence T. "Need for harmonized long-term multi-lake monitoring of African Great Lakes.". 2022. AbstractWebsite

To ensure the long-term sustainable use of African Great Lakes (AGL), and to better understand the functioning of these ecosystems, authorities, managers and scientists need regularly collected scientific data and information of key environmental indicators over multi-years to make informed decisions. Monitoring is regularly conducted at some sites across AGL; while at others sites, it is rare or conducted irregularly in response to sporadic funding or short-term projects/studies. Managers and scientists working on the AGL thus often lack critical long-term data to evaluate and gauge ongoing changes. Hence, we propose a multi-lake approach to harmonize data collection modalities for better understanding of regional and global environmental impacts on AGL. Climate variability has had strong impacts on all AGL in the recent past. Although these lakes have specific characteristics, their limnological cycles show many similarities. Because different anthropogenic pressures take place at the different AGL, harmonized multi-lake monitoring will provide comparable data to address the main drivers of concern (climate versus regional anthropogenic impact). To realize harmonized long-term multi-lake monitoring, the approach will need: (1) support of a wide community of researchers and managers; (2) political goodwill towards a common goal for such monitoring; and (3) sufficient capacity (e.g., institutional, financial, human and logistic resources) for its implementation. This paper presents an assessment of the state of monitoring the AGL and possible approaches to realize a long-term, multi-lake harmonized monitoring strategy. Key parameters are proposed. The support of national and regional authorities is necessary as each AGL crosses international boundaries.

Nguli M, Gatari MJ, Keith Shepherd, Njenga L, Boman J. "Assessment of Essential Micronutrient Levels in Common Beans (Phaseolus vulgaris) in Kenya by Total reflection X-ray Fluorescence (TXRF)." X-Ray Spectrometry. 2022;2022. Abstract

This study reports concentrations of Mn, Fe, Cu and Zn analysed from Kenyan bean grains and leaves using Total Reflection X-ray Fluorescence (TXRF) and Inductively Coupled Plasma – Optical Emission Spectrometry (ICP-OES) methods. Samples of fresh bean leaves and 7 species of dry grains were collected from small scale farmers in Machakos and Kiambu counties. They were delivered to the laboratory where bean grain samples for TXRF analysis were prepared and leaves for both TXRF and ICP-OES. Standard methods of sample preparation successfully tested and used by other authors were used, Average elemental concentrations of the samples were then compared with established sufficiency values mainly given in ranges. Bean leaves from Muguga had sufficient Mn, Ni and Cu concentrations while 6% of the samples had Zn concentrations higher than the sufficiency range. Fe concentrations were consistently high with 97% of the samples having concentrations that were higher than the sufficiency range. No deficiencies were observed from bean leaves from Kyevaluki. For dry bean grains, deficiencies were observed in which four species were found to be deficient in Mn while Zn deficiency was observed in all the species. Fe concentrations were above the sufficiency ranges for all the species but not to toxic levels and 29% of the samples had Cu concentrations that were within the sufficiency range. The obtained data will be essential information for both farmers and policy makers on the nutritional quality of beans in the sampled areas. However, further studies are recommended including soil analysis and elemental bioavailability for full nutritional assessment. Keywords: ICP-OES, hidden hunger, mortality rate, cognitive development, bioavailable

PN R, GO O, O AE, L A, J K. "Assessment of Guideline Concordant Antibiotic Prescribing for Patients with Community Acquired Pneumonia at The Kenyatta National Hospital Medical Wards." Journal of Kenya Association of Physicians. 2022;5(1):34-42. Abstractassessment_of_guideline_concordant_antibiotic_prescribing.pdf

Background: Pneumonia is a major cause of morbidity
and mortality globally. Despite the proven benefits of
guideline concordant antibiotic prescribing, research
has shown that adherence to clinical guideline
recommendations is dismal.
Objectives: The study aims to determine utilization of
Kenyatta National Hospital antibiotic guideline titled
‘The KNH guide to empiric antimicrobial therapy
2018’ in the management of community acquired
pneumonia in the Kenyatta National Hospital medical
wards and the perceived barriers towards the utilization
of this guideline.
Materials and methods: A check list derived from the
Kenyatta National Hospital (KNH) guide to empiric
antimicrobial therapy 2018 was used to assess guideline
concordance based on seven quality indicators:
empiric antibiotic, dose and route of administration,
switch to oral antibiotics, duration of antibiotics (at
least 5 days), collection of microbiological samples
before initiating antibiotics, review of antibiotics at 48
hours and once the culture results are out. Online selfadministered questionnaires were used to determine
attitude and perceived barriers towards utilization
of the KNH guideline among the Internal Medicine
registrars and medical officers.
Analysis: Descriptive statistics were applied in
the representation of each of the seven quality
indicators. These were then compared with the
guideline recommendations and adherence to the
guideline for each parameter was expressed as a
percentage of the total number of patients admitted
with community acquired pneumonia. These were
then graded into the following categories based on the
level of concordance: Good >90%, Intermediate 60-
90%, poor <60%. Questions on the attitude and the
perceived barriers towards KNH guideline utilization
were answered using a 5 point Likert scale. Perceived
barrier statements that were positively formulated
were then recorded so that a lower score meant a
lower level of the perceived barriers and vice versa.
Percentages were then calculated for the total number
of doctors that agreed or strongly agreed that the
barrier was applicable. An open ended question on the
top three barriers to the KNH guideline utilization was
also included in the questionnaire.
Results: For each of the other quality indicators,
adherence to the KNH guideline for patients with
community acquired pneumonia was as follows:
empiric antibiotic choice 48%, collection of samples
for culture prior to antibiotic administration 0%, review
of antibiotics at 48 hours 26.4%, review of antibiotics
with culture results 45.8%, total duration of antibiotics
28.8% and time to switch to oral antibiotics 3.6%. The
top three barriers towards guideline utilization among
the doctors were: unavailability of drugs (52.7%),
inaccessibility of the KNH guideline (45.1%) and lack
of or delay of investigations (34.1%).
Conclusion: This study has demonstrated that the level
of adherence to the seven quality indicators from the
KNH guide is poor with the overall adherence being
35.5%. The recommendation least adhered to was
collection of microbiological samples before initiation
of empiric antibiotics. The most commonly identified
barriers to utilization of the guideline were external
and guideline related barriers.
Key words: Guide to empiric antimicrobial therapy
2018, Guideline Concordance antibiotic prescribing,
Community acquired pneumonia

Ikanya LW, Maina JG, Gachuiri CK, Owino WO, Jr JCBD. "Chemical Composition and Digestibility of Preferred Forage Species by Lactating Somali Camels in Kenya." Rangeland Ecology & Management. 2022;80:61-67.
Ikanya LW, Maina JG, Gachuiri CK, Owino WO, Jr JCBD. "Chemical Composition and Digestibility of Preferred Forage Species by Lactating Somali Camels in Kenya." Rangeland Ecology & Management. 2022;80:61-67.
Ngwili N, Thomas L, Githigia S, Muloi D, Marshall K, Wahome R, Roesel K. "Co-infection of pigs with Taenia solium cysticercosis and gastrointestinal parasites in Eastern and Western Uganda." Parasitology research. 2022;121(1):177-189.
Ng'etich DK, Bett RC, GACHUIRI CHARLESK, Kibegwa FM. "Diversity of Gut Methanogens and Functional Enzymes Associated With Methane Metabolism in Smallholder Dairy Cattle." research square . 2022;2022.
OMAYIO DUKEG, Abong' GO, Okoth MW, GACHUIRI CHARLESK, Mwang'ombe AW. "Effect of pulping methods on the physicochemical properties of the Kenyan red and white‐fleshed guava pulp." JSFA Reports. 2022;2(3):131-142.
MW N, GO O, M M, W S. "Frequency of thyroid dysfunction among rheumatoid arthritis patients at the Kenyatta National Hospital, Nairobi, Kenya." afr j Rheumatal. 2022;10(1):34-44. Abstractfrequency_of_thyroid_dysfunction_among_ra_patients_at_knh.pdf

Background: Rheumatoid Arthritis
(RA) affects 0.5-1% of the adult
population. A higher prevalence of
thyroid dysfunction is observed in
patients with RA compared to the
general population.
Objectives: To establish the
frequency of thyroid dysfunction
among ambulatory RA patients and
to describe the association between
thyroid dysfunction and the patients’
socio-demographic characteristics,
clinical characteristics, level of disease
activity, and their functional status.
Design: This was a cross-sectional
descriptive study.
Methods: Adult patients on follow
up for RA at the outpatient clinic were
sampled. Sociodemographic data was
recorded. The Clinical Disease Activity
Index (CDAI) and Health Assessment
Questionnaire (HAQ) scores were
computed from examination findings
and questionnaires respectively. A
venous blood sample was analyzed for
Thyroid-Stimulating Hormone (TSH),
free triidothyronine (fT3), and free
tetraiodothyronine (fT4). This data
was analyzed to determine frequencies
and associations.
Results: Seventy-six patients were
recruited into the study. Sixty-one
participants were female. The mean
TSH level was 5.8Miu/L. The frequency
of thyroid dysfunction was 47.4%.
Overt hypothyroidism was the most
common form of thyroid dysfunction at
39.5% while 6.6% had Sick Euthyroid.
Majority of the participants, 75%, had
low disease activity, mean CDAI was
11.6. Forty-one (53.9%) participants
had no disability, mean HAQ was
0.5. Correlations between thyroid
dysfunction and advancing age,
duration of disease, level of disease
activity, and functional disability did
not attain statistical significance.
Conclusion: Thyroid dysfunction
is common among patients with RA
with no significant association found
between thyroid dysfunction sociodemographic characteristics, clinical
characteristics, level of disease activity,
and functional status.
Key words: Thyroid dysfunction,
Rheumatoid arthritis, Disease activity,
Functional disability
Introduction
Rheumatoid Arthritis (RA) is a
symmetric polyarthritis with a variety
of systemic manifestations. In the
general population thyroid dysfunction
affects 1-10% of adults, with variations
in geographical areas, age and sex1
.
The causes of thyroid dysfunction
include; iodine deficiency, infections
and autoimmune associated thyroid
disease2
. Thyroid dysfunction is more
prevalent in patients with autoimmune
diseases such as RA. This is attributed
to overlap of autoimmune conditions
that are initiated by loss of tolerance to
self-antigens3
.
The burden of thyroid dysfunction
among RA patients has been found
to vary between 6-47% in various
studies. The entire spectrum of thyroid
dysfunction has been described,
however, hypothyroidism occurs
more frequently. Patients with thyroid
dysfunction have higher RA disease
activity scores and poorer functional
status measured using the

Simon PB, Junga JO, Getinet Mekuriaw Tarekegn, Machuka E, Christian Keambou Tiambo, Kabange D, M KM, Dieudinné RVK, Ochieng JW, Pelle R. "Haplotype analysis of the mitochondrial DNA d-loop region reveals the maternal origin and historical dynamics among the indigenous goat populations in east and west of the Democratic Republic of Congo." Ecology and evolution. 2022;13(2):e8713.
Mbuge DO, Gumbe LO. "Mechanical Properties of Bamboo (Bambusa Vulgaris)." Journal of Engineering in Agriculture and the Environment . 2022;8-no1.
Obonyo  FO, Maingi N, Githigia  SM, Kimeli P, Nyaboga EN. "Occurrence of serum antibodies to Toxoplasma gondii and associated risk factors in donkeys from central Kenya." Tropical Animal Health and Production. 2022;54(1):77.
OMAYIO DUKEG, Abong’ GO, Okoth MW, GACHUIRI CHARLESK, Mwangombe AW. "Physicochemical and Processing Qualities of Guava Varieties in Kenya." International Journal of Fruit Science. 2022;22(1):329-345.
Okumu MO, Mbaria JM, Gikunju JK, Mbuthia PG, Madadi VO, Ochola FO, Maloba KN, Nderitu JG. "Preclinical efficacy testing of three antivenoms against Naja ashei venom-induced lethality." Toxicon: X 14 (2022) 100124. https://doi.org/10.1016/j.toxcx.2022.100124 . 2022.
Barre A, Karanja DN, Bebora LC, Gitao CG. "Prevalence of Brucellosis in Camel Slaughter Population in Garissa County, Kenya. ." OSR Journal of Agriculture and Veterinary Science. 2022;15(1):39-46.
Kamuti NM, Mbuthia, P.G., Waruiru, R.M., Githigia SM, Keya EA. "Prevalence, Etiology and Risk Factors Associated with Occurrence of Canine Cutaneous Myiasis in Kitui County, Kenya." Hindawi Journal of Veterinary Medicine International. 2022.
Tangus CJ, Chege JN, Karanja DN, Gachuiri CK. "The prevalence,intensity and spectrum of gastrointestinal parasites in selected sheep farms in Kasarani sub-county, Nairobi County, Kenya." to Hindawi Journal of veterinary medicine international. 2022.
Kimani PK´ethe, Mbuge D, Gitau AN. "Properties of Nonwoven Fabrics Containing Immobilized Superabsorbent Polymer Particles for Air Conditioning in Grain Dryers, Applied Engineering in Agriculture." American Society of Agricultural and Biological Engineers. 2022;38(2)(ISSN 0883-8542).
Watene G-A, Aboge G, Gitau G, Nthiwa D, Bett B. "Seroprevalence And Risk Factors Of Coxiella Burnetii Infecting Cattle Raised In Pastoral Areas Of Narok, Kenya." Research square. 2022.
Ngwili N, Thomas L, Wahome RG, Githigia S, Johnson N, Roesel K. "Stakeholders' Knowledge, Attitude, and Perceptions on the Control of Taenia solium in Kamuli and Hoima Districts, Uganda." Frontiers in Veterinary Science. 2022:363.
Ngwili N, Thomas L, Githigia S, Johnson N, Raphael Wahome KR. "Stakeholders' Knowledge, Attitude, and Perceptions on the Control of Taenia solium in Kamuli and Hoima Districts, Uganda." Frontiers in Veterinary Science. 2022:363.
Osiro OA, Kariuki DK, Gathece LW. "Synthesis and characterisation of ionomer-type cements from alkaline activated kaolinite." Non-crystalline solids: X. 2022;doi: https://doi.org/10.1016/j.nocx.2021.100079.
Meng T, Shi M, Guo Y, Wang H, Fu N, Liu Z, Huang B, Lei C, Su X, Peng B, others. "Multifunctional Ag-coated CuO microbowl arrays for highly efficient, ultrasensitive, and recyclable surface-enhanced Raman scattering." Sensors and Actuators B: Chemical. 2022;354:131097. Abstract
n/a
Su G, Gao A, Peng B, Hu J, Zhang Y, Liu F, Zhang H, Zhan P, Wu W. "Observation of in-plane exciton–polaritons in monolayer WSe2 driven by plasmonic nanofingers." Nanophotonics. 2022. Abstract
n/a
Liu Z, Guo Y, Chen Z, Gong T, Li Y, Niu Y, Cheng Y, Lu H, Deng L, Peng B. "Observation of intrinsic crystal phase in bare CrI3 ferromagnetism." arXiv preprint arXiv:2204.13312. 2022. Abstract
n/a
2021
G N, A N. "MANAGERS’ LEVEL OF KNOWLEDGE IN DE: A CRITICAL DETERMINANT OF TUTOR-LEARNER INTERACTION IN BLENDED LEARNING AT THE UNIVERSITY OF NAIROBI.". In: 4TH ANNUAL FORENSIC VICTIMOLOGY AND VICTIM SUPPORT CONFERENCE, KENYA. Nairobi, Kenya; 2021.
Chikwana N, Maina EN, Gavamukulya Y, Bulimo W, Wamunyokoli F. "Antiproliferative Activity, c-Myc and {FGFR}1 Genes Expression Profiles and Safety of Annona muricata Fruit Extract on Rhabdomyosarcoma and {BALB}/c Mice." Journal of Complementary and Alternative Medical Research. 2021:30-46. AbstractWebsite
n/a
Geno KPO, Ralwala AO. "Assessment of Heat Stress Exposure on Construction Workers in Hot and Humid Environments during the Covid-19 Pandemic Period.". In: (Re)Setting Built Environment Theory and Practice in a Post-pandemic World: Disrupted Buildings or Design for Disruption. School of Architecture and Building Sciences (SABS) online (virtual) conference, JKUAT; 2021.
Akinyi J, Mwaniki A, Gichamba A, Kariuki D, Chand P, Munene S, Nyakinyua C, Nzangi B, Akinyi V, Betsy M, Cosmas K, Mwangi M. "NanoSatellite Platform for the University of Nairobi (NaSPUoN) Student Project.". In: 72nd International Astronautical Congress (IAC). Dubai, United Arab Emirates (presented online); 2021.
Nyumba TO, Sang CC, Olago DO, Marchant R, Waruingi L, Githiora Y, Kago F, Mwangi M, Owira G, Barasa R, Omangi S. "Assessing the ecological impacts of transportation infrastructure development: A reconnaissance study of the Standard Gauge Railway in Kenya." PLOS ONE. 2021;16(1):e0246248-. AbstractWebsite

Transportation infrastructure, such as railways, roads and power lines, contribute to national and regional economic, social and cultural growth and integration. Kenya, with support from the Chinese government, is currently constructing a standard gauge railway (SGR) to support the country’s Vision 2030 development agenda. Although the actual land area affected by the SGR covers only a small proportion along the SGR corridor, a significant proportion of the area supports a wide range of ecologically fragile and important ecosystems in the country, with potential wider impacts. This study used a qualitative content analysis approach to gain an understanding and perceptions of stakeholders on the potential ecological impacts of the interactions between the SGR and the traversed ecological systems in Kenya. Three dominant themes emerged: 1) ecosystem degradation; 2) ecosystem fragmentation; and 3) ecosystem destruction. Ecosystem degradation was the most commonly cited impact at while ecosystem destruction was of the least concern and largely restricted to the physical SGR construction whereas the degradation and fragmentation have a much wider footprint. The construction and operation of the SGR degraded, fragmented and destroyed key ecosystems in the country including water towers, protected areas, community conservancies and wildlife dispersal areas. Therefore, we recommend that project proponents develop sustainable and ecologically sensitive measures to mitigate the key ecosystem impacts.

Tanyi WN, Gachuno O, Odero T, Farquhar C, Kimosop D, Mayi A. "Factors affecting adherence to antiretroviral therapy among children and adolescents living with HIV in the Mbita Sub-County Hospital, Homa Bay- Kenya." Afr Health Sci. 2021;21(Suppl):18-24. AbstractWebsite

Adequate adherence to antiretroviral therapy (ART) is key to the successful treatment of children and adolescents living with HIV. Continuous ART Adherence is the key factor for virologic suppression and stability of the immune system and prevents the occurrence of opportunistic infections. Children and adolescents struggle with adherence to ART for various reasons, including a poor psychosocial support system and clinic attendance.

Theunissen F, Cleps I, Goudar S, QURESHI ZAHIDA, Owa OO, Mugerwa K, Piaggio G, Gülmezoglu MA, Nakalembe M, Byamugisha J, Osoti A, Mandeep S, Poriot T, Gwako G, Vernekar S, Widmer M. "Correction to: Cost of hospital care of women with postpartum haemorrhage in India, Kenya, Nigeria and Uganda: a financial case for improved prevention." Reprod Health. 2021;18(1):57.
Dean WH, Buchan J, Gichuhi S, Philippin H, Arunga S, Mukome A, Admassu F, Lewis K, Makupa W, Otiti J, Kim MJ, Macleod D, Cook C, Burton MJ. "Simulation-based surgical education for glaucoma versus conventional training alone: the GLAucoma Simulated Surgery (GLASS) trial. A randomised controlled, educational intervention efficacy trial in Kenya, South Africa, Tanzania, Uganda and Zimbabwe." Br J Ophthalmol. 2021. AbstractWebsite

Background/aim: Glaucoma accounts for 8% of global blindness and surgery remains an important treatment. We aimed to determine the impact of adding simulation-based surgical education for glaucoma.

Methods: We designed a randomised controlled, parallel-group trial. Those assessing outcomes were masked to group assignment. Fifty-one trainee ophthalmologists from six university training institutions in sub-Saharan Africa were enrolled by inclusion criteria of having performed no surgical trabeculectomies and were randomised. Those randomised to the control group received no placebo intervention, but received the training intervention after the initial 12-month follow-up period. The intervention was an intense simulation-based surgical training course over 1 week. The primary outcome measure was overall simulation surgical competency at 3 months.

Results: Twenty-five were assigned to the intervention group and 26 to the control group, with 2 dropouts from the intervention group. Forty-nine were included in the final intention-to-treat analysis. Surgical competence at baseline was comparable between the arms. This increased to 30.4 (76.1%) and 9.8 (24.4%) for the intervention and the control group, respectively, 3 months after the training intervention for the intervention group, a difference of 20.6 points (95% CI 18.3 to 22.9, p<0.001). At 1 year, the mean surgical competency score of the intervention arm participants was 28.6 (71.5%), compared with 11.6 (29.0%) for the control (difference 17.0, 95% CI 14.8 to 19.4, p<0.001).

Conclusion: These results support the pursuit of financial, advocacy and research investments to establish simulation surgery training units and courses including instruction, feedback, deliberate practice and reflection with outcome measurement to enable trainee glaucoma surgeons to engage in intense simulation training for glaucoma surgery.

Trial registration number: PACTR201803002159198.

Theunissen F, Cleps I, Goudar S, QURESHI ZAHIDA, Owa OO, Mugerwa K, Piaggio G, Gülmezoglu MA, Nakalembe M, Byamugisha J, Osoti A, Mandeep S, Poriot T, Gwako G, Vernekar S, Widmer M. "Cost of hospital care of women with postpartum haemorrhage in India, Kenya, Nigeria and Uganda: a financial case for improved prevention." Reprod Health. 2021;18(1):18. Abstract

Access to quality, effective lifesaving uterotonics in low and middle-income countries (LMICs) remains a major barrier to reducing maternal deaths from postpartum haemorrhage (PPH). Our objective was to assess the costs of care for women who receive different preventative uterotonics, and with PPH and no-PPH so that the differences, if significant, can inform better resource allocation for maternal health care.

Gogri PY, Bore MC, Rips AGT, Reddy JC, Rostov AT, Vaddavalli PK. "Femtosecond laser-assisted big bubble for deep anterior lamellar keratoplasty." J Cataract Refract Surg. 2021;47(1):106-110. Abstract

To assess the utility of a femtosecond laser-assisted stromal channel to assist the creation of a big bubble (BB) for deep anterior lamellar keratoplasty (DALK) surgery in cadaveric corneas.

Vogel JP, Vannevel V, Robbers G, Gwako G, Lavin T, Adanikin A, Hlongwane T, Pattinson RC, Qureshi ZP, Oladapo OT. "Prevalence of abnormal umbilical arterial flow on Doppler ultrasound in low-risk and unselected pregnant women: a systematic review." Reprod Health. 2021;18(1):38. Abstract

While Doppler ultrasound screening is beneficial for women with high-risk pregnancies, there is insufficient evidence on its benefits and harms in low- and unselected-risk pregnancies. This may be related to fewer events of abnormal Doppler flow, however the prevalence of absent or reversed end diastolic flow (AEDF or REDF) in such women is unknown. In this systematic review, we aimed to synthesise available data on the prevalence of AEDF or REDF.

Miruka SA, Aboge GO, Macharia RW, George O Obiero, Omwenga IM. "Beta hemolysin gene of Staphylococcus phage 3AJ_2017 genome is a suitable molecular marker for identification and characterization of pathogenic Staphylococcus aureus." Vet Med Sci. 2021. Abstract

Staphylococcus aureus cause diseases both in humans and animals. These diseases range from mild to fatal infections thus necessitating development of a specific molecular method for detection of pathogenic S. aureus.

Gwako GN, Obimbo MM, Gichangi PB, John Kinuthia, James N Kiarie, Gachuno OW, Were F. "Association between obstetric and medical risk factors and stillbirths in a low-income urban setting." Int J Gynaecol Obstet. 2021;154(2):331-336. Abstract

To evaluate the association between obstetric and medical risk factors and stillbirths in a Kenyan set-up.

Baguiya A, Bonet M, Cecatti JG, Brizuela V, Curteanu A, Minkauskiene M, Jayaratne K, Ribeiro-do-Valle CC, Budianu M-A, Souza JP, Kouanda S. "Perinatal outcomes among births to women with infection during pregnancy." Arch Dis Child. 2021;106(10):946-953. Abstract

This study is part of the Global Maternal Sepsis Study (GLOSS). It aimed to estimate neonatal near-miss (NNM) and perinatal death frequency and maternal risk factors among births to women with infection during pregnancy in low-income and middle-income countries (LMIC).

Baguiya A, Bonet M, Cecatti JG, Brizuela V, Curteanu A, Minkauskiene M, Jayaratne K, Ribeiro-do-Valle CC, Budianu M-A, Souza JP, Kouanda S. "Perinatal outcomes among births to women with infection during pregnancy." Arch Dis Child. 2021;106(10):946-953. Abstract

This study is part of the Global Maternal Sepsis Study (GLOSS). It aimed to estimate neonatal near-miss (NNM) and perinatal death frequency and maternal risk factors among births to women with infection during pregnancy in low-income and middle-income countries (LMIC).

Mitchell EJ, Pallotti P, Qureshi ZP, Daniels JP, Oliver M, Were F, Osoti A, Gwako G, Kimani V, Opira J, Ojha S. "Parents, healthcare professionals and other stakeholders' experiences of caring for babies born too soon in a low-resource setting: a qualitative study of essential newborn care for preterm infants in Kenya." BMJ Open. 2021;11(6):e043802. Abstract

Prematurity is the leading cause of global neonatal and infant mortality. Many babies could survive by the provision of essential newborn care. This qualitative study was conducted in order to understand, from a family and professional perspective, the barriers and facilitators to essential newborn care. The study will inform the development of an early warning score for preterm and low birthweight infants in low and middle income countries (LMICs).

Gwako GN, Were F, Obimbo MM, John Kinuthia, James N Kiarie, Gachuno OW, Gichangi PB. "Association between utilization and quality of antenatal care with stillbirths in four tertiary hospitals in a low-income urban setting." Acta Obstet Gynecol Scand. 2021;100(4):676-683. Abstract

About 2.6 million stillbirths per year occur globally with 98% occurring in low- and middle-income countries including Kenya, where an estimated 35 000 stillbirths occur annually. Most studies have focused on the direct causes of stillbirth. The aim of this study was to determine the association between antenatal care utilization and quality with stillbirth in a Kenyan set up. This information is key when planning strategies to reduce the stillbirth burden.

Burton MJ, Ramke J, Marques AP, Bourne RRA, Congdon N, Jones I, Ah Tong BAM, Arunga S, Bachani D, Bascaran C, Bastawrous A, Blanchet K, Braithwaite T, Buchan JC, Cairns J, Cama A, Chagunda M, Chuluunkhuu C, Cooper A, Crofts-Lawrence J, Dean WH, Denniston AK, Ehrlich JR, Emerson PM, Evans JR, Frick KD, Friedman DS, Furtado JM, Gichangi MM, Gichuhi S, Gilbert SS, Gurung R, Habtamu E, Holland P, Jonas JB, Keane PA, Keay L, Khanna RC, Khaw PT, Kuper H, Kyari F, Lansingh VC, Mactaggart I, Mafwiri MM, Mathenge W, McCormick I, Morjaria P, Mowatt L, Muirhead D, Murthy GVS, Mwangi N, Patel DB, Peto T, Qureshi BM, Salomão SR, Sarah V, Shilio BR, Solomon AW, Swenor BK, Taylor HR, Wang N, Webson A, West SK, Wong TY, Wormald R, Yasmin S, Yusufu M, Silva JC, Resnikoff S, Ravilla T, Gilbert CE, Foster A, Faal HB. "The Lancet Global Health Commission on Global Eye Health: vision beyond 2020." Lancet Glob Health. 2021;9(4):e489-e551.Website
Vogel JP, Comrie-Thomson L, Pingray V, Gadama L, Galadanci H, Goudar S, Rose Laisser, Lavender T, Lissauer D, Misra S, Pujar Y, Qureshi ZP, Amole T, Berrueta M, Dankishiya F, Gwako G, Homer CSE, Jobanputra J, Meja S, Nigri C, Mohaptra V, Osoti A, Roberti J, Solomon D, Suleiman M, Robbers G, Sutherland S, Vernekar S, Althabe F, Bonet M, Oladapo OT. "Usability, acceptability, and feasibility of the World Health Organization Labour Care Guide: A mixed-methods, multicountry evaluation." Birth. 2021;48(1):66-75. Abstract

The World Health Organization's (WHO) Labour Care Guide (LCG) is a "next-generation" partograph based on WHO's latest intrapartum care recommendations. It aims to optimize clinical care provided to women and their experience of care. We evaluated the LCG's usability, feasibility, and acceptability among maternity care practitioners in clinical settings.

Golden L, Chaya S, Reichmuth K, Visagie A, Ayuk A, Kwarteng Owusu S, Marangu D, Affendi N, Lakhan A, Gray D, Vanker A, Zar H, Zampoli M. "Aetiology and presentation of childhood pleural infections in the post-pneumococcal conjugate vaccine era in South Africa." Afr J Thorac Crit Care Med. 2021;27(4). Abstract

Complications of respiratory infections including pleural effusion (PE) are associated with a high morbidity. Differentiating between PE caused by (Mtb) infection and other bacterial infections in endemic areas is difficult in children, thus, impacting treatment.

Garelick S, Russell JM, Dee S, Verschuren D, Olago DO. "Atmospheric controls on precipitation isotopes and hydroclimate in high-elevation regions in Eastern Africa since the Last Glacial Maximum.". 2021;567:116984. AbstractWebsite

Tropical Africa experienced large changes in hydroclimatic conditions since the Last Glacial Maximum (LGM), ∼26.5 to 19 thousand years (ka or kyr) ago. The hydrogen isotopic composition of fossil leaf waxes (δDwax), assumed to record past variations in the hydrogen isotopic composition of precipitation (δDprecip), is increasingly being used to study past hydroclimatic change in Africa, and are commonly interpreted to reflect variation in the amount of precipitation through time (i.e., the amount effect). Although there are now many such δDprecip records from tropical Africa, there are few robust δDprecip records from easternmost equatorial Africa of sufficient length and resolution to evaluate the mechanisms governing hydroclimate variation during and since the LGM. We produced a new δDprecip record based on analyses of δDwax in sediment cores collected from Lake Rutundu, situated at an elevation of 3,078 meters above sea level (m asl) on Mt. Kenya. This record displays large variations in δDprecip corresponding with known climate events over the past 25 kyr, including D-enrichment during the Heinrich 1 stadial (H1) and the Younger Dryas (YD), and D-depletion during the Holocene portion of the African Humid Period (AHP). We also observe D-depletion during the LGM relative to the late Holocene, which, considering the amount effect, could be interpreted to imply that LGM climate conditions were wetter than today. However, because other hydroclimate proxies at this site indicate a drier LGM climate at Lake Rutundu, and since precipitation isotopes at this high-elevation site are likely influenced by different processes than at low elevations, we used a single-column Rayleigh distillation model to evaluate temperature and altitude-related effects on high-elevation δDprecip. This revealed that a change in the temperature lapse rate exerts strong control on δDprecip in this high-elevation setting, and that a steeper lapse rate could explain the observed D-depletion during the LGM at our site. Comparison of the Lake Rutundu δDprecip record with other leaf-wax based δDprecip records from East Africa indicates that changes in the meridional precipitation gradient associated with the mean annual position and intensity of the tropical rain belt, in turn driven by precessional insolation forcing, were likely a primary control on East African hydroclimate over the past 25 kyr, thereby contributing to overall regional drying during the LGM.

Garelick S, Russell JM, Dee S, Verschuren D, Olago DO. "Atmospheric controls on precipitation isotopes and hydroclimate in high-elevation regions in Eastern Africa since the Last Glacial Maximum.". 2021;567:116984. AbstractWebsite

Tropical Africa experienced large changes in hydroclimatic conditions since the Last Glacial Maximum (LGM), ∼26.5 to 19 thousand years (ka or kyr) ago. The hydrogen isotopic composition of fossil leaf waxes (δDwax), assumed to record past variations in the hydrogen isotopic composition of precipitation (δDprecip), is increasingly being used to study past hydroclimatic change in Africa, and are commonly interpreted to reflect variation in the amount of precipitation through time (i.e., the amount effect). Although there are now many such δDprecip records from tropical Africa, there are few robust δDprecip records from easternmost equatorial Africa of sufficient length and resolution to evaluate the mechanisms governing hydroclimate variation during and since the LGM. We produced a new δDprecip record based on analyses of δDwax in sediment cores collected from Lake Rutundu, situated at an elevation of 3,078 meters above sea level (m asl) on Mt. Kenya. This record displays large variations in δDprecip corresponding with known climate events over the past 25 kyr, including D-enrichment during the Heinrich 1 stadial (H1) and the Younger Dryas (YD), and D-depletion during the Holocene portion of the African Humid Period (AHP). We also observe D-depletion during the LGM relative to the late Holocene, which, considering the amount effect, could be interpreted to imply that LGM climate conditions were wetter than today. However, because other hydroclimate proxies at this site indicate a drier LGM climate at Lake Rutundu, and since precipitation isotopes at this high-elevation site are likely influenced by different processes than at low elevations, we used a single-column Rayleigh distillation model to evaluate temperature and altitude-related effects on high-elevation δDprecip. This revealed that a change in the temperature lapse rate exerts strong control on δDprecip in this high-elevation setting, and that a steeper lapse rate could explain the observed D-depletion during the LGM at our site. Comparison of the Lake Rutundu δDprecip record with other leaf-wax based δDprecip records from East Africa indicates that changes in the meridional precipitation gradient associated with the mean annual position and intensity of the tropical rain belt, in turn driven by precessional insolation forcing, were likely a primary control on East African hydroclimate over the past 25 kyr, thereby contributing to overall regional drying during the LGM.

Baba MM, Bitew M, Fokam J, Lelo EA, Ahidjo A, Asmamaw K, Beloumou GA, Bulimo WD, Buratti E, Chenwi C, Dadi H, D'Agaro P, De Conti L, Fainguem N, Gadzama G, Maiuri P, Majanja J, Meshack W, Ndjolo A, Nkenfou C, Oderinde BS, Opanda SM, Segat L, Stuani C, Symekher SL, Takou D, Tesfaye K, Triolo G, Tuki K, Zacchigna S, Marcello A. "Diagnostic performance of a colorimetric RT -LAMP for the identification of SARS-CoV-2: A multicenter prospective clinical evaluation in sub-Saharan Africa.". 2021;40:101101. Abstract1-s2.0-s2589537021003813-main-1.pdf1-s2.0-s2589537021003813-main-1.pdfWebsite

BackgroundManagement and control of the COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus SARS-CoV-2 is critically dependent on quick and reliable identification of the virus in clinical specimens. Detection of viral RNA by a colorimetric reverse transcription loop-mediated isothermal amplification (RT-LAMP) is a simple, reliable and cost-effective assay, deployable in resource-limited settings (RLS). Our objective was to evaluate the intrinsic and extrinsic performances of RT-LAMP in RLS.
Methods
This is a multicenter prospective observational study of diagnostic accuracy, conducted from October 2020 to February 2021 in four African Countries: Cameroon, Ethiopia, Kenya and Nigeria; and in Italy. We enroled 1657 individuals who were either COVID-19 suspect cases, or asymptomatic and presented for screening. RNA extracted from pharyngeal swabs was tested in parallel by a colorimetric RT-LAMP and by a standard real time polymerase chain reaction (RT-PCR).
Findings
The sensitivity and specificity of index RT LAMP compared to standard RT-PCR on 1657 prospective specimens from infected individuals was determined. For a subset of 1292 specimens, which underwent exactly the same procedures in different countries, we obtained very high specificity (98%) and positive predictive value (PPV = 99%), while the sensitivity was 87%, with a negative predictive value NPV = 70%, Stratification of RT-PCR data showed superior sensitivity achieved with an RT-PCR cycle threshold (Ct) below 35 (97%), which decreased to 60% above 35.
Interpretation
In this field trial, RT-LAMP appears to be a reliable assay, comparable to RT-PCR, particularly with medium-high viral loads (Ct < 35). Hence, RT-LAMP can be deployed in RLS for timely management and prevention of COVID-19, without compromising the quality of output.

Sura M, Osoti A, Gachuno O, Musoke R, Kagema F, Gwako G, Ondieki D, Ndavi PM, Ogutu O. "Effect of umbilical cord milking versus delayed cord clamping on preterm neonates in Kenya: A randomized controlled trial." PLoS One. 2021;16(1):e0246109. Abstract

Delayed cord clamping (DCC) is a placental to new-born transfusion strategy recommended by obstetric and gynaecological societies. Though not widely adopted, umbilical cord milking (UCM) may achieve faster transfusion when DCC cannot be performed such as when a neonate requires resuscitation.

Kimani E, Muhula S, Kiptai T, Orwa J, Odero T, Gachuno O. "Factors influencing TB treatment interruption and treatment outcomes among patients in Kiambu County, 2016-2019." PLoS One. 2021;16(4):e0248820. AbstractWebsite

Tuberculosis (TB) is the leading cause of mortality as a single infectious agent globally with increasing numbers of case notification in developing countries. This study seeks to investigate the clinical and socio-demographic factors of time to TB treatment interruption among Tuberculosis patients in Kiambu County, 2016-2019. We retrospectively analyzed data for all treatment outcomes patients obtained from TB tracing form linked with the Tuberculosis Information Basic Unit (TIBU) of patients in Kiambu County health facilities using time to treatment interruption as the main outcome. Categorical variables were presented using frequency and percentages. Kaplan-Meir curve was used to analyze probabilities of time to treatment interruptions between intensive and continuation phases. Log-rank test statistics was used to compare the equality of the curves. Cox proportion model was used to determine determinants of treatment interruption. A total of 292 participants were included in this study. Males were 68%, with majority (35%) of the participants were aged 24-35 years; 5.8% were aged 0-14 years and 5.1% aged above 55 years. The overall treatment success rate was 66.8% (cured, 34.6%; completed 32.2%), 60.3% were on intensive phase of treatment. Lack of knowledge and relocation were the major reasons of treatment interruptions. Patients on intensive phase were 1.58 times likely to interrupt treatment compared to those on continuation phase (aHR: 1.581; 95%CI: 1.232-2.031). There is need to develop TB interventions that target men and middle aged population in order to reduce treatment interruption and increase the treatment success rates in the County and Country.

Peter SG, Kariuki HW, Aboge GO, Gakuya DW, Maingi N, Mulei CM. "Prevalence of Ticks Infesting Dairy Cattle and the Pathogens They Harbour in Smallholder Farms in Peri-Urban Areas of Nairobi, Kenya." Veterinary Medicine International. 2021;2021:9501648. AbstractWebsite

This study aimed at determining the tick species infesting dairy cattle in Nairobi, Kenya, and the pathogens they harbour. While ticks are well-known vectors of major bacterial pathogens of both veterinary importance and public health importance, few studies have investigated the range of the tick species and the associated pathogens, especially present in unique dairy production systems, which compromise animal welfare, such as those in peri-urban areas. A cross-sectional study was undertaken involving 314 randomly selected dairy cattle in 109 smallholder farms. Each animal was examined for attached ticks followed by morphological tick identification at the species level. Genomic DNA was extracted from each of the ticks, and 16S rDNA gene was amplified for pathogen identification. Sequencing of the amplicons and subsequent BLASTn analysis, multiple sequence alignment, and phylogenetic reconstruction were performed to confirm the species of the pathogens. Sixty-six (21.0%) of the cattle examined had ticks. A total of 94 adult ticks were found on the cattle, and of these, 63 (67.0%), 18 (19.1%), and 13 (13.8%) were in the genera Rhipicephalus, Amblyomma, and Hyalomma, respectively. Twelve tick species in Rhipicephalus genus and two in Amblyomma and Hyalomma genera were identified. Although Rh. decoloratus was the most prevalent tick (24.5% (23/94)), the emerging Rh. microplus (6.4% (6/94)) was also identified. The DNA of Rickettsia was detected in the ticks, with Rickettsia conorii in H. rufipes and A. variegatum, and Rickettsia aeschlimannii in Rh. microplus and H. rufipes, while Ehrlichia ruminantium and E. canis were in A. variegatum. In conclusion, the study reported a wide range of tick species present in the study area including Rhipicephalus microplus, which is an emerging tick species in parts of Kenya. The ticks harboured DNA of Rickettsia and Ehrlichia, highlighting possible animal and human health concerns. Hence, effective tick control strategies remain paramount to prevent potential diseases associated with the harboured pathogens.

MM B, M B, J F, EA L, A A, K A, GA B, WD B, E B, C C, H D, P D'A, L DC, N F, A M. "Diagnostic performance of a colorimetric RT -LAMP for the identification of SARS-CoV-2: A multicenter prospective clinical evaluation in sub-Saharan Africa." EClinicalMedicine. 2021. Abstract
n/a
Araka E, Oboko R, Maina E, Gitonga RK. " A Conceptual Educational Data Mining Model for Supporting Self-Regulated Learning in Online Learning Environments." https://www.igi-global.com/. 2021:15. Abstract

Self-regulated learning is attracting tremendous researches from various communities such as information communication technology. Recent studies have greatly contributed to the domain knowledge that the use self-regulatory skills enhance academic performance. Despite these developments in SRL, our understanding on the tools and instruments to measure SRL in online learning environments is limited as the use of traditional tools developed for face-to-face classroom settings are still used to measure SRL on e-learning systems. Modern learning management systems (LMS) allow storage of datasets on student activities. Subsequently, it is now possible to use Educational Data Mining to extract learner patterns which can be used to support SRL. This chapter discusses the current tools for measuring and promoting SRL on e-learning platforms and a conceptual model grounded on educational data mining for implementation as a solution to promoting SRL strategies.

Mugo, N, Nancy N. Karanja, Gachene CN, Klaus Dittert, Harun I. Gitari, E. S-G. " Response of potato crop to selected nutrients in central and eastern highlands of Kenya. ." Cogent Food & Agriculture. . 2021;7(1):1898762..
Debrah I, Afrane YA, Amoah LE, Ochwedo KO, Mukabana WR, Zhong D, Zhou G, Lee M, Onyango SA, Magomere EO, Atieli HE, Githeko AK, Yan G. ", Larval ecology and bionomics of Anopheles funestus in highland and lowland sites in western Kenya." PLoS ONE . 2021;16(10):e0255321.
GIKONYO NAOMI, Ndiritu A. "1. Transformational Leadership in Adopting Online Learning. Kenya policy briefs .Volume 2 No. 1.". 2021. Abstract

Key messages
Effective training is a key determinant for adopting online learning in educational institutions.
Transformational leadership characteristics are important in managing change that is required in learning
institutions during the COVID-19 pandemic and beyond.
Modelling the way is a necessity in university management of online teaching and learning through COVID-19 Season

Josephine Wangechi Kirui, Muthama NJ, Gachuiri CK, Ngaina JN. "Adaptation and mitigation strategies to climate change by smallholder dairy farmers: A case of Nandi county in Kenya." Journal of Sustainability, Environment and Peace. 2021;4(1):39-47.
Gichure M, Onono J, Wahome R, Gathura P. "Analysis of the benefits and production challenges of working donkeys in smallholder farming systems in Kenya." Veterinary World. 2021;13(11):2346.
Hashim I, Omosa LK, Nchiozem-Ngnitedem V-A, Onyari JM, Maru SM, Guefack M-GF, Mbaveng AT, Kuete V. "Antibacterial Activities and Phytochemical Screening of Crude Extracts from Kenyan Macaranga Species Towards MDR Phenotypes Expressing Effux Pumps." Pharmacognosy Communications. 2021;11(2):119-126.hashim_et_al_2021_pharmacognosy_communications.pdf
Jepkoech C, Omosa LK, Nchiozem-Ngnitedem V-A, Kenanda EO, Guefack M-GF, Mbaveng AT, Kuete V, Heydenreich M. "Antibacterial secondary metabolites from Vernonia auriculifera Hiern (Asteraceae) against MDR phenotypes." Natural Products Research. 2021:https://doi.org/10.1080/14786419.2021.1953024.jepkoech_et_al_2021_natural_products_research.pdf
Armah FA, Henneh IT, Amponsah IK, Biney RP, F M, J A, W A, Ahmed MA, Adokoh CK, Adukpo G, O AD, Gathumbi PK. "Antidepressant and Anxiolytic Effects and Subchronic Toxicity of the Aerial Parts of Psychotria ankasensis J.B.Hall (Rubiaceae) in Murine Models." Hindawi Veterinary Medicine International. 2021;Volume 2021, Article ID 5543320, 18 pages.armah_et_al_2021.pdf
Mbindyo CM, Gitao CG, Plummer PJ, Kulohoma BW, Mulei CM, Bett R. "Antimicrobial Resistance Profiles and Genes of Staphylococci Isolated from Mastitic Cow’s Milk in Kenya." Antibiotics. 2021;10(772):https://doi.org/10.3390/antibiotics10070772.antibiotics-10-00772_1.pdf
Juma M, Sankaradoss A, Ndomb R, Mwaura P, Damodar T, Nazir J, Pandit A, Khurana R, Masika M, Chirchir R, Gachie J, Krishna S, Sowdhamin R, Anzala O, Iyer MS. "Antimicrobial resistance profiling and phylogenetic analysis of Neisseria gonorrhoeae clinical isolates from Kenya in resource limited setting." Frontiers in Microbiology. 2021. AbstractWebsite

Background: Africa has one of the highest incidences of gonorrhea. Neisseria gonorrhoeae is gaining resistance to most of the available antibiotics, compromising treatment across the world. Whole-genome sequencing (WGS) is an efficient way of predicting AMR determinants and their spread in the population. Recent advances in next-generation sequencing technologies like Oxford Nanopore Technology (ONT) have helped in the generation of longer reads of DNA in a shorter duration with lower cost. Increasing accuracy of base-calling algorithms, high throughput, error-correction strategies, and ease of using the mobile sequencer MinION in remote areas lead to its adoption for routine microbial genome sequencing. To investigate whether MinION-only sequencing is sufficient for WGS and downstream analysis in resource-limited settings, we sequenced the genomes of 14 suspected N. gonorrhoeae isolates from Nairobi, Kenya.

Methods: Using WGS, the isolates were confirmed to be cases of N. gonorrhoeae (n = 9), and there were three co-occurrences of N. gonorrhoeae with Moraxella osloensis and N. meningitidis (n = 2). N. meningitidis has been implicated in sexually transmitted infections in recent years. The near-complete N. gonorrhoeae genomes (n = 10) were analyzed further for mutations/factors causing AMR using an in-house database of mutations curated from the literature.

Results: We observe that ciprofloxacin resistance is associated with multiple mutations in both gyrA and parC. Mutations conferring tetracycline (rpsJ) and sulfonamide (folP) resistance and plasmids encoding beta-lactamase were seen in all the strains, and tet(M)-containing plasmids were identified in nine strains. Phylogenetic analysis clustered the 10 isolates into clades containing previously sequenced genomes from Kenya and countries across the world. Based on homology modeling of AMR targets, we see that the mutations in GyrA and ParC disrupt the hydrogen bonding with quinolone drugs and mutations in FolP may affect interaction with the antibiotic.

Conclusion: Here, we demonstrate the utility of mobile DNA sequencing technology in producing a consensus genome for sequence typing and detection of genetic determinants of AMR. The workflow followed in the study, including AMR mutation dataset creation and the genome identification, assembly, and analysis, can be used for any clinical isolate. Further studies are required to determine the utility of real-time sequencing in outbreak investigations, diagnosis, and management of infections, especially in resource-limited settings.

Chikwana N, Maina EN, Gavamukulya Y, Bulimo W, Wamunyokoli F. "Antiproliferative Activity, c-Myc and FGFR1 Genes Expression Profiles and Safety of Annona muricata Fruit Extract on Rhabdomyosarcoma and BALB/c Mice." Journal of Complementary and Alternative Medical Research. 2021;14(4):30-46.
kariuki J, DiasTibihika P, ManuelCurto, EsayasAlemayehu, GeroldWinkler, HaraldMeimberg. "Application of microsatellite genotyping by amplicon sequencing for delimitation of African tilapiine species relevant for aquaculture.". 2021.
Okumu MO, Mbuthia… PG, Mbaria JM, Gikunju JK. "Artemia salina as an animal model for the preliminary evaluation of snake venom-induced toxicity." Toxicon: X, 2021. 2021;X, 2021(X, 2021).
Okumu MO, Mbaria JM, Gikunju JK, Mbuthia PG, Madadi VO, Ochola FO, Jepkorir MS. "Artemia salina as an animal model for the preliminary evaluation of snake venominduced toxicity." Toxicon. DOI: https://doi.org/10.1016/j.toxcx.2021.100082. 2021.
Gitau AK, Oyieke FA, W.R. Mukabana. "Assessment of the role played by domestic animals in jigger infection in Kandara sub-county, Kenya (case control study)." The Pan African Medical Journal. 2021;39:231.
Gitau AK2021, Oyieke FA, Wolfgang Richard Mukabana. "Assessment of the role played by domestic animals in jigger infection in Kandara sub-county, Kenya (case control study)." Pan African Medical Journal. 2021;39:231.2021-1.pdf
Gitau 2. AK, Oyieke FA, Wolfgang Richard Mukabana. "Assessment of tungiasis management knowledge in Kandara sub county Mukabana, ." Journal of Entomology and Zoology studies. 2021;9(4):127-136.2021-2.pdf
Gitau AK, Oyieke FO, Mukabana WR. "Assessment of tungiasis management knowledge in Kandara sub county, Kenya." Journal of Entomology and Zoology Studies. 2021;9(4):127-136.
Miruka SA, G.O. A, Macharia RW, George O Obiero, Omwenga IM. "Beta hemolysin gene of Staphylococcus phage 3AJ_2017 genome is a suitable molecular marker for identification and characterization of pathogenic Staphylococcus aureus." Veterinary Medicine and Science. 2021;8(2):845-851.
Wangila AJ, Gachuiri CK, Muthomi JW, Ojiem JO. "Biomass yield and quality of fodder from selected varieties of lablab (lablab purpureus l) in Nandi South sub-county of Kenya." Online journal of Animal and Feed Research. 2021;11(1):28-35.
Grossheim L, Ruff P, Ngoma T, Vanderpuye V, Wango GM, Ochieng P, Palmer D, Kouya F, Lasebikan N, Ntekim A, Ngoma M, Bih N, Malloum A, Elzawawy A, Kerr D, Ngwa W. "Cancer and Covid-19 Experiences at African Cancer Centers: The Silver Lining." JCO Global Oncology. 2021;7:410-415.
G.N.Kithure J, M.W. K. "Canning Food Processes may be a source of threat to the Consumer. International Journal of Scientific Research and Innovative Technology (IJSRIT)." International Journal of Scientific Research and Innovative Technology (IJSRIT).. 2021;8(3).abstract_2.pdf
Edith Wairimu, Mburu J, GACHUIRI CHARLESK, Ndambi A. "Characterization of dairy innovations in selected milksheds in Kenya using a categorical principal component analysis." Tropical Animal Health and Production. 2021;53(2):1-12.
Ngwili N, Lian T, Githigia S, Muloi D, Marshal K, Wahome R, Roesel K. "co-infection of pigs with Taenia solium cysticercosis and gastrointestinal parasites in Eastern and Western Uganda." Parasitology Research. 2021;2021(https://doi.org/10.1007/s00436-021-07380-9):1-14.
Gateri AM, Ondicho TG, Karimi E. "Correlates of Domestic Violence against Men: Qualitative insights from Kenya." African Journal of Gender, Society, and Development. 2021;10(3):87-111.
Makau MC, Powell J, Prendergast J, de Late PL, Morrison LJ, Gathura P, Fisch A. "Corrigendum to “Inverted CD4+/CD8+ T cell ratio in Boran (Bos indicus) cattle”[Vet. Immunol. Immunopathol." Veterinary Immunology and Immunopathology. 2021:235.
Obiero LM, Abong' GO, W OM, OMAYIO DUKEG, G OE, Villacampa M. "Current practices concerning the environmental management systems among horticultural processing MSMES in Kenya." East African Journal of Science, Technology and Innovation,. 2021;2(special Issue):1-16.current_practices_of_msmes.pdf
Mutunga PK, Gichuhi W. "Decision-Making Power and Contraceptive Use among Couples of Child-Bearing Age in Kenya.". In: Gender Statistics for Evidence-Based Policies: Women’s Economic Empowerment, Health and Gender Based Violence. Nairobi: UN Women; 2021.
FW N, Ouyang K AA, J O'o, GW A, D Z. "Does Keloid Histology Influence Recurrence?" Am J Dermatol. doi. 2021;10(PMID: 33464754.). AbstractWebsite

Abstract
Keloids are fibroproliferative disorders characterized by high recurrence rates, with few factors known to influence the same. We conducted a study to determine whether keloid histology influences recurrence. This was a prospective longitudinal study to determine whether histopathological parameters of keloid influence recurrence. Patients with keloids managed by surgical excision were followed up at Kenyatta National Hospital between August 2018 and July 2020. The excised keloids were processed for histology using hematoxylin,/eosin, Masson, and trichrome stains. The slides were analyzed for inflammatory cells, fibroblasts, and capillary density using the hot spot technique and correlated to keloid recurrence. Postoperative follow-up was for a minimum of 1 year. A total of 90 patients with 104 keloids were recruited in the study. Overall keloid recurrence rate was 28.6%. There was a correlation between the absolute count of more than 50 per High power field of lymphocytes, fibroblasts, and macrophages with recurrence of the disease. The sensitivity and specificity for the above parameters were lymphocytes 48% and 81%, macrophages 57% and 83%, mast cells 32% and 33%, and fibroblasts 41% and 91%, respectively. There was no correlation between mast cells and vascularity status with recurrence. Routine histology should, therefore, be performed to determine these parameters. Close monitoring and second-line therapy should be considered for patients with elevated macrophages and/or lymphocytes so as to reduce the risk of recurrence.

MO F, ME T, JI V, CA F, M R, AM K, R V, OB A‐B, R A, B G, SZ M, A A, H D, A V, RJ S, for the Group ECCA. "An ecological study on the association between universal health service coverage index, health expenditures, and early childhood caries." BMC Oral Health. 2021;2021; 21:126.(2021; 21:126.):2021; 21:126.
Shiwani, D.I., Kalai, J.M., Gatumu JC, Akala WJ. "Effect of Head Teachers’ Acquisition of Teaching and Learning Resources on Implementation of Inclusive Education in Public Primary Schools in Nairobi City County. ." Journal of Pedagogy, Andragogy and Heutagogy in Academic Practice (JPAHAP). 2021;2(1):90-108.
Kimeli P, Vanleeuwen J, Gitau G, Heider L, McKenna S, Greenwood S. "Effect of housing improvement and other factors on the growth of heifer calves on Kenyan smallholder dairy farms." Tropical Animal Health and Production. 2021;53(1):1-15.
Mutuli GP, Mbuge DO, Gitau AN. "Effect of humidity on Aflatoxin contamination on selected African leafy vegetables. ." Journal of Food Science and Technology. 2021.
Bone G, Parr T, Brameld J, Elmes M, Gonzalez-Carranza Z, Koech O. The effect of mezquite pod flour in a wheat-based diet on broiler chicken growth performance. University of Nottingham, Nottingham, UK: Science Direct; 2021.
ADWATI SM, Edalia LG, Gathece L. "EFFECT OF PAST DENTAL EXPERIENCE ON PATIENTS ATTITUDES FOLLOW UP ORAL HEALTH CARE INTERVENTION." EAMJ. 2021;VOL 98 NO2 PG 3529-3537:VOL 98 NO2 PG 3529-3537.
Sura M, Osoti A, Gachuno O, Musoke R, Kagema F, Gwako G, Ondieki D, Ndavi PM, Ogutu O. "Effect of umbilical cord milking versus delayed cord clamping on preterm neonates in Kenya: A randomized controlled trial." PloS one. 2021;16(1):e0246109.
Mandeep S, Osoti A, Gachuno O, Musoke R, Kagema F, Gwako G, Ondieki D, Ndavi PM. "Effect of umbilical cord milking versus delayed cord clamping on preterm neonates in Kenya: A randomized controlled trial.". 2021.
Musembei LM, Bett RC, Gachuiri CK, Mbondo BK, Kibegwa FM. "Effects of freezing as a post-harvest storage technique on quality of Friesian crossbred cattle milk." African Journal of Food Science. 2021;45(7):298-303.
Musembei LM, Bett RC, Gachuiri CK, Mbondo BK, Kibegwa FM. "Effects of freezing as a post-harvest storage technique on quality of Friesian crossbred cattle milk." African Journal of Food Science. 2021;45(7):298-303.
Musembei LM, Bett RC, Gachuiri CK, Mbondo BK, Kibegwa FM. "Effects of freezing as a post-harvest storage technique on quality of Friesian crossbred cattle milk." African Journal of Food Science. 2021;15(7):298-303.
Sila JM, Guto PM, Michira IN, Mwaura FB, Muge EK. "Electrochemical Determination of Penicillin G in Cow Milk and pharmaceuticals in SDS/Acetate buffer." Int. J. Electrochem. Sci.. 2021;16(4):1-13.
Chepkwony EC, Gitao GC, Muchemi GM, Sangula AK, Kairu-Wanyoike SW. "Epidemiological study on foot-and-mouth disease in small ruminants: Sero-prevalence and risk factor assessment in Kenya." PLOS ONE . 2021;16 ((8)):e0234286. https://doi.org/10.1371/journal.pone.0234286.goat_fmdplos_one.pdf
Omambia VM, Nguta JM, Mitema ES, Musila FM, Nyak DM, Ali HM, Gervason MA. "Ethnopharmacology, pharmacological activities, and chemistry of the Hypericum genus." The Journal of Phytopharmacology. 2021;10(2):105-113.
Wanjira J, Ndiwa TC, Gichuki N, Wykstra M. "Evaluating the efficacy of flashing lights in deterring livestock attacks by predators: a case study of Meibae Community Conservancy, Northern Kenya." East African Journal of Science, Technology and Innovation. 2021;2(3).
Kimeli P, Vanleeuwen J, Gitau GK, Heider LC, Heider LC, McKenna SL, Greenwood SJ, Richards S. "Evaluation of environmental and comfort improvements on affective welfare in heifer calves on smallholder dairy farms." Preventive Veterinary Medicine. 2021;189:105296.
NM M, GO O. "Fibromyalgia: Reviewing the epidemiology and gender-based differences in Africa." African Journal of Rheumatology. 2021;7(1):3-7. Abstractfibromyalgia.pdf

Abstract
Objectives: Fibromyalgia is a
complex disorder which presents with
chronic widespread musculoskeletal
pain, together with other symptoms
like fatigue, sleep disturbances and
cognitive disturbance. The cause remains
unclear but it is postulated that there
are abnormalities in neurohormonal
profile and central sensitization to pain
as the main mechanism. It is known to
occur more commonly in females than
males. This study set out to look at these
differences in terms of epidemiology and
gender differences.
Data source: We conducted online and
public library searches using the English
language.
Data extraction: We reviewed several
papers and research work focusing on
epidemiology and differences in gender
presentation. The period of the search was
between the years 1990 up to 2020.
Conclusion: Fibromyalgia is a commonly
occurring rheumatologic condition.
Gender differences exist with regard to
epidemiology, clinical presentation and
health seeking behaviors. Population
based studies would be of use to establish
the prevalence in Africa. More studies
would be necessary to explain the gender
differences noted in the many aspects
of the disease including response to
treatment.
Key words: Fibromyalgia, Fibromyalgia
in women, Gender differences and impact

NM M, GO O. "Fibromyalgia: Reviewing the epidemiology and gender-based differences in Africa." African Journal of Rheumatology. 2021;7(1):3-7. Abstractfibromyalgia.pdf

Objectives: Fibromyalgia is a
complex disorder which presents with
chronic widespread musculoskeletal
pain, together with other symptoms
like fatigue, sleep disturbances and
cognitive disturbance. The cause remains
unclear but it is postulated that there
are abnormalities in neurohormonal
profile and central sensitization to pain
as the main mechanism. It is known to
occur more commonly in females than
males. This study set out to look at these
differences in terms of epidemiology and
gender differences.
Data source: We conducted online and
public library searches using the English
language.
Data extraction: We reviewed several
papers and research work focusing on
epidemiology and differences in gender
presentation. The period of the search was
between the years 1990 up to 2020.
Conclusion: Fibromyalgia is a commonly
occurring rheumatologic condition.
Gender differences exist with regard to
epidemiology, clinical presentation and
health seeking behaviors. Population
based studies would be of use to establish
the prevalence in Africa. More studies
would be necessary to explain the gender
differences noted in the many aspects
of the disease including response to
treatment.
Key words: Fibromyalgia, Fibromyalgia
in women, Gender differences and impact
of fibromyalgia

SS G, G A, P A, K B, R B, G C, KJ C, ACR C, T C, YO C, D D, ML F, MO F, A G, HH H, V J, A K, SC L, P L, VP M, T M, Y M, N P, A T-M, ECM L, CH C. "Global Oral Health Policies and Guidelines: Using Silver Diamine Fluoride for Caries Control. Front Oral Health." Front Oral Health. 2021;2021; 2:685557(2021; 2:685557):2021; 2:685557.
Ncebere JM, Mbuthia PG, Waruiru RM, Gathumbi PK. "Gross and Histopathology of Goats Feeding on Opuntia stricta in Laikipia County, Kenya." Hindawi Veterinary Medicine International. 2021;Volume 2021(Article ID 8831996, 12 pages).
Ncebere JM, Mbuthia PG, Waruiru RM, Gathumbi PK. "Gross and histopathology of goats feeding on Opuntia stricta in Laikipia County, Kenya." Hindawi Veterinary Medicine International. 2021;2021(Article ID 8831996).
G.N. KJ, G.W. N, K.K. E. "How Safe is the Water Consumed in Different Parts of Nairobi, Kenya? International Journal of Research and Innovation in Applied Science (IJRIAS) ." International Journal of Research and Innovation in Applied Science (IJRIAS). 2021;VI(VII):ISSN 2454-6194.abstract.pdf
Wanja ND, Agnèse J-F, Ford AGP, Day JJ, Ndiwa TC, Turner GF, Getahun A. Identifying and conserving Tilapiine cichlid species in the twenty-first century. Springer; 2021.
Peter K, John VL, George G, Luke H, Shawn MK, Spencer G. "Impact of calf housing improvement and farmer training on finances, management and animal welfare perceptions of Kenyan smallholder dairy farmers." Journal of Development and Agricultural Economics. 2021;13(2):119-129.
Kimeli P, Vanleeuwen J, Gitau G, Heider L, McKenna S, Greenwood S. "Impact of calf housing improvement and farmer training on finances, management and animal welfare perceptions of Kenyan smallholder dairy farmers ." Journal of Development and Agricultural Economics. 2021;13(2):119-129.
Nyandega IA, Gurong T, Okello P, Ongoma V. "Influence of Convective Coupled Equatorial Kelvin Waves on March-May Precipitation over East Africa." Geogrophica Pannonica. 2021;25(1):24-34.
T H, W KI, G. MR. "The Influence of Parental Incomes on Internal Efficiency of Public Primary Schools in Western Province-Rwanda." Journal of Humanities And Social Science (IOSR-JHSS) . 2021;26(6):06-16.
Gatere AW. "The Language of Love." The Counsel-ling Magazine. 2021;1(1):33-35.the_language_of_love.pdf
Rahman M, Ahmed R, Moitra M, Damschroder L, Brownson R, Chorpita B, Idele P, Gohar F, Huang KY, Saxena S, Lai J, Peterson SS, Harper G, McKay M, Amugune B, Esho T, Ronen K, Othieno C, Kumar M. "Mental Distress and Human RightsViolations During COVID-19: A RapidReview of the Evidence InformingRights, Mental Health Needs, andPublic Policy Around VulnerablePopulations." Front. Psychiatry . 2021;11:603875.
Gatimu J, Gakuu C, Ndiritu A. "Moderating Influence of Contextual Determinants on Relationship between Monitoring and Evaluation Practices and Performance of County Maternal Health Programmes in Kenya. Public Administration Research journal Vol. 10, No. 2 (2021).". 2021. Abstract

Effective monitoring and evaluation practices is widely known to help improve performance, the quality and effectiveness of planning and decision making and achievement of results. This is because monitoring focuses on the implementation process and progress towards the achievement of project objectives. Despite the Kenya Government’s effort to promote County Maternal Health programmes through legal frameworks such as the county integrated monitoring and evaluation practices tool, and while there is empirical evidence that monitoring and evaluation practices contributes to enhanced performance, actual performance of county health sector across Kenya remains poor. The purpose of the study was to establish moderating influence of contextual determinants on the relationship between monitoring and evaluation practices and performance of County Maternal Health programmes in Kenya. The paradigm that is suitable for this study is pragmatism. The study adopted a descriptive survey research design. The study targeted 8 regional blocks in Kenya (Central,, Western Coast, Eastern, Rift Valley, North Eastern, Nyanza, Nairobi) where one county from each block was selected. From these counties the target population was 1165 respondents including Medical officers, Clinical Officers, Trained Community health workers, Nurses, County Health Management Team and County Delivery Unit officers from level 4 and 5 hospitals. Sampling procedure for this study was guided by the research design which is descriptive survey design. Stratified random sampling was used to obtain 282 respondents from which information was obtained for this study. The research instruments that were used for data collection are: a self-administered structured questionnaire and interview guides. Descriptive and inferential data analysis techniques were used in this study. Regression was conducted for testing the study hypothesis. The research established that there was a strong correlation between the performance of county maternal health programmes and contextual determinants (r=0.638, p=0.000<0.05). The study found that after introduction of contextual determinants into the relationship, and the interaction term in model 2 increased the R square by 0.08. This implies that the interaction between contextual determinants and monitoring and evaluation practices explains 8.0% variations in performance of county maternal health programmes. The study concluded that contextual determinants significantly moderate the relationship between monitoring and evaluation practices and performance of County Maternal Health Programmes in Kenya. The study recommends investing in robust and dynamic technical coordination platforms that can sustain the agenda for change. and at all levels is necessary to ensure the sustainability of M&E reforms in the health sector.

Gatimu J, Gakuu C, Ndiritu A. "Monitoring and Evaluation Practices and Performance of County Maternal Health Programmes October 2021European Scientific Journal 17(37):39 DOI:10.19044/esj.2021.v17n37p39.". 2021. Abstract

The study sought to establish the relationship between monitoring and evaluation practices and performance of County Maternal Health programmes in Kenya. The combined monitoring and evaluation practices included planning for M&E, stakeholder engagement, capacity building for M&E, and M&E data use. The study adopted a descriptive survey research design. To obtain 282 respondents, stratified random sampling was used. A self-administered structured questionnaire was the study's research instrument. Using descriptive narratives, qualitative data was analyzed within specific themes. Quantitative data was analyzed descriptively using measures of central tendencies and measures of dispersion. Regression was conducted for testing the study hypotheses. Data was presented using frequency tables. The study found that stakeholders’ engagement in M&E and capacity building for M&E influenced the performance of County Maternal Health Programmes in Kenya. The study also found that the respondents agreed that planning for M&E and the data management for M&E. This implied that the combined monitoring and evaluation practices influence performance of County Maternal Health Programmes in Kenya.The study found a strong correlation between the performance of county maternal health programmes and combined monitoring and evaluation practices. The study concluded that combined planning for M&E monitoring and evaluation practices influenced the performance of county maternal health programmes. The study suggests that management develop an effective methodology as well as raise awareness of M&E activities for the success of the project. The study also suggests that human resources issues such as workers charged with monitoring and evaluation ought to have technical capabilities, and roles and duties of monitoring and evaluation personnel should be outlined at the start of projects. To ensure M&E sustainability health sector reforms, investments in strong and vibrant technical harmonization platforms that can sustain the change agenda at all times and every required level.

FW N, K O, A A, J O, GW A. "Multiple Cytokines Elevated in Patients with Keloids: Is It an Indication of Auto-Inflammatory Disease?" J. Inflam Res. 2021;14(7):2465-2470. AbstractWebsite

Abstract
Background: Inflammation seems to play a major role in the pathophysiology of keloids. However, the role of cytokines in keloid pathophysiology has not been fully evaluated with only a few cytokines studied. We undertook this study to compare various cytokines in patients with keloids and a control group of patients without keloids nor family history of keloids so as to determine which cytokines are elevated and could thus be critical in keloid formation.

Methods: This was a cross-sectional study of patients with keloids and a control group of those without. Patients in both groups were matched for age, sex and body mass index. Their plasma was analyzed for both inflammatory and anti-inflammatory cytokines using the Bio-flex ElisaTM method. Comparisons of cytokines means in both groups were done using Student's t-test.

Results: A total of 84 participants with 42 participants in each group were followed during the study. Male to female ratio was 1:2. Age ranges were similar with a mean of 29.6 years. A total of 28 cytokines were assayed. Statistically significant differences were noted in 15 of the 28 cytokines assayed with 11 being elevated more in keloid patients with only four in the non-keloid forming group. Among elevated cytokines in keloid patients were granulocyte colony-stimulating factors, granulocyte-monocyte-colony-stimulating factors, interleukins 4, 6 and 13.

Conclusion: Patients with keloids have significantly higher cytokines compared with non-keloid forming patients. This finding suggests that keloid formation could be influenced by multiple inflammatory cytokines, an indication that the patient's immune system could play a role in keloid formation akin to auto-inflammatory disease.

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