Hellen N. Kariuki1, Titus I. Kanui, Abiy Yenesew, Nilesh B. Patel, Paul M. Mbugua. Antinocieptive Activities of the Root Extracts of Rhus natalensis Kraus and Senna singueana

Citation:
N. DRKARIUKIHELLEN. "Hellen N. Kariuki1, Titus I. Kanui, Abiy Yenesew, Nilesh B. Patel, Paul M. Mbugua. Antinocieptive Activities of the Root Extracts of Rhus natalensis Kraus and Senna singueana.". In: Phytopharmacology 2012, 2(2) 1-6. Inforesights Publishing Ltd.; 2012.

Abstract:

Rhus natalensis and Senna singuaenae are traditional African plants commonlyused as medicinal plant in East Africa for the management of pain. The plants areused for management of rheumatism among others. This study investigated theantinociceptive activities of R. natalensis and S. singuaenae in Swiss albino miceusing the tail-flick and hot plate tests. Extract solvent (vehicle), morphine andaspirin were employed as controls. Root extract of R. natalensis (100 and 200 mg /kg) and 100 mg /kg of S. singuaenae showed no significant antinociceptive activity in the hot plate while the 200mg /kg of S. singuaenae showed significant antinociceptive activity (p<0.05). In the tail flick tests, root extract of R. natalensis (100 and 200 mg / kg) showed highly significant antinociceptive activity (p<0.01) while 200mg / kg of S. singuaenae showed significant antinociceptive activity (p<0.05) compared to the controls. The 100 mg /kg of S. singuaenae showed no significant antinociceptive activity in the tail flick. This study lends support to the anecdotal evidence for use of R. natalensis and S. singuaenae in the management of painful conditions..Keywords: Rhus natalensis; Senna singuaenae; analgesic,;

Notes:

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