Serum erythropoietin in patients with anaemia on HAART attending the Kenyatta National Hospital, Comprehensive Care Centre

Citation:
G.O.Oyoo, D.K.Katukui, J.Rajab. "Serum erythropoietin in patients with anaemia on HAART attending the Kenyatta National Hospital, Comprehensive Care Centre." EAJP. 2014;Vol. 1(1):2-6.

Abstract:

Background: Anaemia is the leading haematological abnormality in HIV/AIDS and an
independent contributor to morbidity and mortality. HAART has been shown to be effective
in reversing anaemia in HIV/AIDS, however a significant proportion of patients remain
anaemic despite being on antiretroviral therapy. Deficiency of erythropoietin has been
demonstrated as a cause of anaemia in HIV infected HAART naïve patients. The levels of
erythropoietin have not been studied in anaemic patients who are on HAART.
Objectives: To describe serum EPO levels of HIV infected anaemic patients who have been
on HAART for more than six months.
Design: Cross sectional descriptive study.
Setting: The study was carried out at a national hospital HIV treatment and follow-up
outpatient facility: Comprehensive Care Centre, Kenyatta National Hospital.
Methods: A total of 196 HIV elisa positive HAART experienced patients with anaemia
visiting the Comprehensive Care Centre were consecutively recruited. They were evaluated
by total blood counts, CD4 count, documented WHO clinical stage and serum erythropoietin
levels. Serum erythropoietin levels were measured by IMMULITE 2000 Elisa method.
Accrued data was entered in SPSS version 17 and analyzed therein.
Results: A total of 196 HIV positive adult patients with anaemia and who had been on
HAART for more than six months were evaluated. A total of 181 (92.3%) were found to
have a deficient erythropoietin response to anaemia in HIV, (EPO < 500IU/L). In this study
Hb was the main predictor of erythropoietin response.
Conclusion: Erythropoietin deficiency is nearly universal in anaemic patients on HAART
for more than six months.

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