An evaluation of quality of life in ambulatory patients with systemic lupus erythematosus attending rheumatology clinic in Kenyatta National Hospital

Citation:
Oyoo.G.O, Odhiambo.J, Amayo.E. "An evaluation of quality of life in ambulatory patients with systemic lupus erythematosus attending rheumatology clinic in Kenyatta National Hospital.". In: ISSN.; 2014.

Abstract:

Background: Systemic Lupus
Erythematosus (SLE) is a chronic
autoimmune disease that affects all
organs of the body. It is becoming
increasingly clear that SLE is not as rare
in Kenya as was previously thought. Due
to its chronicity SLE has been known to
affect the quality of life of those affected
by it. There is minimal data on SLE in
East Africa and especially in Kenya. The
quality of life of SLE patients in this
country has never been assessed.
Objectives: To document the quality
of life of patients with SLE in Kenyatta
National Hospital using LUPUS QOL
questionnaire. We also sought to correlate
HRQOL with duration of illness, drugs
used and age of the patient.
Design: This was a cross sectional study
done on patients attending Rheumatology
Clinic in Kenyatta National Hospital.
Methods: Patients who satisfy the ACR
criteria were consecutively recruited.
All patients with SLE attending the
clinic were included in the study.
Consent was obtained from the patients
after which their demographic data was
obtained. Patients were examined for
the presence of malar rash, discoid rash,
arthritis/athralgia, photosensitivity, CNS
symptoms, serositis and oral ulcers. The
patients then filled the LUPUS QOL
questionnaire. The information acquired
was then analysed using SPSS version
17.0 using student t test and regression
analysis. The quality of life was
calculated and then correlated with age,
duration of illness and drug management.
Results: Sixty two patients were analysed
(60 females 2 males). Mean age of the
population was 37.3 years (range 14-71
years). All patients had some level of
education with 61.3% of the population
having some form of secondary education.
Most patients 54.8% were married.
Mean age of diagnosis was 34.5 years
with mean duration of illness 1.5 years.
Majority (88.7%) had arthritis/ athralgia,
oral ulcers (62.9%), malar rash (59.7%),
photosensitivity (58.1%), serositis
(32.3%), CNS symptoms (27.4%) and
discoid rash (17.7%). Patients scored
globally low in all domains of LUPUS
QOL. Highest domain was planning
63.7 (29.3), emotional health 61.3 (26.5),
burden to others 58.9 (31.2), fatigue 57.5
(30.0), pain 56.6 (29.6), physical health
54.0 (23.3), body image 47.1 (24.2)
intimate relations 41.1 (38.4).The most
common drug in use in our population
was prednisone at 74.2%. This was
followed by HCQ at 69.4%, NSAIDS
54.8%, azathioprine 37.1%, methotrexate
22.6%, mycofenolate mofetil 8.1%, CCB
11.3%, cyclosporine 3.2%. HRQOL
correlated positively with advance in age
for the domains. Physical health, burden
to others, emotional health and fatigue.
There was no correlation between
HRQOL and duration of illness or drugs
used by the population.
Conclusion: The HRQOL of our SLE
patients was found to be low in all
domains and to correlate with advance
in age in the domains of physical health,
burden to others, emotional health and
fatigue. However there was no correlation
with duration of illness or the drugs used
by the patients

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