Bio

DR GERALD MUCHEMI

Born in October 1952. He attended the University of Nairobi where he obtained a Bachelor of Veterinary Medicine (BVM) degree in 1979. He was employed by the Ministry of Agriculture and Livestock Development in 1979 as a Veterinary Research Officer in the Wildlife Disease Research Section. He got a scholarship from IDRC to pursue a MSc degree in Wildlife Medicine at the Ontario Veterinary College , University of Guelph, Canada. On completion he was appointed Head of Wildlife Disease Section.

Publications


2012

Chepkwony, EC, Gitao CG, Muchemi. GM.  2012.  Seroprevalence of Foot and Mouth Disease in the Somali Eco-System in Kenya. Abstract

The aim of this study was to document the prevalence of Foot and Mouth Disease (FMD) in the arid and semi-arid areas where the pastoral mode of livestock rearing is pre-dominant in Kenya especially in the Somali Eco-system. A cross-sectional sero-epidemiological study was conducted in the Somali Ecosystem (SES) in Kenya with 499 sera collected from January 2007 to December 2008 to determine the seroprevalence of Foot and Mouth Disease (FMD) in cattle in the SES. The samples were screened against the five serotypes of FMD known to be in circulation in Kenya i.e., FMD O. A, C, SAT1, SAT2 and measured by microneutralizationassay. The overall sero-prevalence of FMD in the Somali-ecosystem was found to be 45.3% (95% CI = 40.96 to 49.66%). Twenty seven percent of all animals sampled tested positive for only one serotype while 17.6% tested positive for multiple serotypes. There was a high prevalence (p#0.05) in the circulation of serotype O (23 and 95% CI = 20.13-27.57%) as compared with the other serotypes, while the prevalence of serotype C was significantly lower (p#0.05) compared to the other four serotypes (1.6 and 95% CI = 0.82-3.12). Wajir district recorded the highest prevalence (24.8 and 95% CI = 16.71 to 27.54) while Garissa district recorded the least (6.2%). There was no significant sero-prevalence variation in relation to sex while older animals had higher sero-prevalences. The pastoral mode of livestock production, porous borders and wildlife inter-phase are significant factors that need consideration for effective control programmes.

2011

Chai, D, Farah I, Muchemi G.  2011.  Sparganosis in non-human primates. Abstract

The spargana were recovered from two vervets (Cer-copithecus aethiops), one olive baboon (Papio anubis anubis), and one Highland syke (Cercopithecus miĀ¬tis albortorquas). The animals were in good physical condition and, upon opening the abdominal cavities, numerous unattached white and soft, ribbon-like, motile tape-worm larvae were found (Fig. 1). Many were lying on the mesentery and on most of the abdominal organs, and some were found unattached on the abĀ¬dominal muscles and subcutaneous tissues.

Kamanja, IT, Githigia SM, Muchemi GM, Mwandawiro C.  2011.  A Survey of Schistosoma Bovis in cattle in Kwale District Kenya. Abstract

A study was carried out to determine the prevalence and possible public health importance of Schistosoma bovis in cattle in Kwale District. Abattoir surveys were carried out where the mesenteric veins of the carcasses were visually examined for the presence of adult S. bovis worms. Three abattoirs were visited. These were Ngombeni and Kwale slaughter houses in Matuga division and Mwambungo slaughter house in Msabweni division. Identification of S. bovis eggs was done after sedimentation of rectal faecal samples. A total of 492 samples from various divisions in the district were analyzed. Snails were sampled using the scooping method in the water bodies and digging in riverbeds. They were put in 24-well microtitre plates under the shade for at least two hours to induce shedding of cercariae. Stool and urine samples from school going children from Matuga Msabweni and Kinango divisions were analyzed for S. bovis eggs. The prevalence of S. bovis eggs as 16.9% while the prevalence of S. bovis adult worms was 25.1%. Snails of the genus Bulinus were recovered from the various water bodies. No S. bovis eggs were recovered from the stool samples. Eggs of S. haematobium were recovered from urine samples. Polymerase chain reaction (PCR) confirmed that the adult worms recovered from slaughtered cattle were S. bovis. It was concluded that S.bovis is prevalent in cattle in Kwale district. The water bodies were infested with the snail intermediate host.

2009

Asaava, LL, Kitala PM, Gathura PB, Nanyingi MO, Schelling E.  2009.  A survey of bovine cysticercosis/human taeniosis In Northern Turkana District, Kenya. AbstractWebsite

Bovine cysticercosis is a zoonosis that is mainly of socioeconomic ,H1(1 public health impor, ranee. A survey of this disease was.carried ou t in Northern Turkana District, Kenya to estimate the prevalence through both serology and meat inspection. to determine the prevalence or the adult tapeworm in the human definitive 11Ost, and to determine risk factors for cattle seropositivity. This information is of public health importance and will be of use inassessing economic losses due to downgrading, refrigeration or condemnation of infested carcasses. The study area was stratified into the three livestock grazing regions of Oropoi to the south, Lokichoggio--Mogilla centrally and Kibish in the north for the purposes of rhe serological and questionnaire (n = 53 herd owners) data. Five ada/wars (grazing units) were selected and 34, 63. 49, 75 and 571 cattle serum samples obtained from these. The slaughter slabs of Lokichoggio and Kakurna were visited and 188 serum samples were obtained from slaughter cattle and compared to results of meat inspection. Human stool samples were collected in each of the three grazing areas and 66, 97 and 78 samples were obtained. The seroprevalence of cysticercosis in cattle was estimated at 16.7% (95% CI 13-20,9%) using a secretory-excretory antigen detection ELISA. There was poor agreement between meat inspection and serology (I< = 0.025; P = 0.2797). The prevalence of taeniasis was estimated as 2.5% (95% CI 0.8-5.6%) by microscopy. A backwards elimination logistic regression analysis indicated that the grazing unit (Ada/war), the deworrning history of household members and the distance (>2km) of gl-azing fields from the homestead were significant expla-natory variables for cattle being found to be positive on serology. An intra-cluster correlation coefficient (ICC) of 0,07 (0.02-0.12); P < 0.0001 was calculated for bovine cysticercosis in this area

2006

2005

MUCHEMI, MWANGIG.  2005.  Origin and diversification of the human parasite Schistosoma mansoni. Molecular Ecology (2005) 14:3889 - 3902.. East African Agricultural and Forestry Journal. : EAMJ Abstract

Department of Biology, University of New Mexico, Albuquerque, New Mexico 87131 USA. Schistosoma mansoni is the most widespread of the human-infecting schistosomes, present in 54 countries, predominantly in Africa, but also in Madagascar, the Arabian Peninsula, and the Neotropics. Adult-stage parasites that infect humans are also occasionally recovered from baboons, rodents, and other mammals. Larval stages of the parasite are dependent upon certain species of freshwater snails in the genus Biomphalaria, which largely determine the parasite's geographical range. How S. mansoni genetic diversity is distributed geographically and among isolates using different hosts has never been examined with DNA sequence data. Here we describe the global phylogeography of S. mansoni using more than 2500 bp of mitochondrial DNA (mtDNA) from 143 parasites collected in 53 geographically widespread localities. Considerable within-species mtDNA diversity was found, with 85 unique haplotypes grouping into five distinct lineages. Geographical separation, and not host use, appears to be the most important factor in the diversification of the parasite. East African specimens showed a remarkable amount of variation, comprising three clades and basal members of a fourth, strongly suggesting an East African origin for the parasite 0.30-0.43 million years ago, a time frame that follows the arrival of its snail host. Less but still substantial variation was found in the rest of Africa. A recent colonization of the New World is supported by finding only seven closely related New World haplotypes which have West African affinities. All Brazilian isolates have nearly identical mtDNA haplotypes, suggesting a founder effect from the establishment and spread of the parasite in this large country. PMID: 16202103 [PubMed - indexed for MEDLINE]

2003

MWANGI, DRMUCHEMIG.  2003.  Mungai, B.N., Njagi, E.M.N., Muli, F.W., Agola, E.L., Morgan, J.A.T, DeJong, R.J., Karanja, D.M.S, Muchemi, G.M., Loker, E.S. and Mkoji, G.M. 2003. The presence of Schistosoma rodhaini in Western Kenya, and its implication on the epidemiology of Schistoso. East African Agricultural and Forestry Journal. : EAMJ Abstract

Department of Biology, University of New Mexico, Albuquerque, New Mexico 87131 USA. Schistosoma mansoni is the most widespread of the human-infecting schistosomes, present in 54 countries, predominantly in Africa, but also in Madagascar, the Arabian Peninsula, and the Neotropics. Adult-stage parasites that infect humans are also occasionally recovered from baboons, rodents, and other mammals. Larval stages of the parasite are dependent upon certain species of freshwater snails in the genus Biomphalaria, which largely determine the parasite's geographical range. How S. mansoni genetic diversity is distributed geographically and among isolates using different hosts has never been examined with DNA sequence data. Here we describe the global phylogeography of S. mansoni using more than 2500 bp of mitochondrial DNA (mtDNA) from 143 parasites collected in 53 geographically widespread localities. Considerable within-species mtDNA diversity was found, with 85 unique haplotypes grouping into five distinct lineages. Geographical separation, and not host use, appears to be the most important factor in the diversification of the parasite. East African specimens showed a remarkable amount of variation, comprising three clades and basal members of a fourth, strongly suggesting an East African origin for the parasite 0.30-0.43 million years ago, a time frame that follows the arrival of its snail host. Less but still substantial variation was found in the rest of Africa. A recent colonization of the New World is supported by finding only seven closely related New World haplotypes which have West African affinities. All Brazilian isolates have nearly identical mtDNA haplotypes, suggesting a founder effect from the establishment and spread of the parasite in this large country. PMID: 16202103 [PubMed - indexed for MEDLINE]

MWANGI, DRMUCHEMIG.  2003.  Mungai, B.N., Agola, E.L., Morgan, J.A.T, DeJong, R.J., Karanja, D.M.S., Muchemi, G.M., Loker, E.S. and Mkoji, G.M. 2003. Schistosoma rodhaini in Kenya revisited. Abstract presented at the Biodiversity of African Freshwater Snails . East African Agricultural and Forestry Journal. : EAMJ Abstract

Department of Biology, University of New Mexico, Albuquerque, New Mexico 87131 USA. Schistosoma mansoni is the most widespread of the human-infecting schistosomes, present in 54 countries, predominantly in Africa, but also in Madagascar, the Arabian Peninsula, and the Neotropics. Adult-stage parasites that infect humans are also occasionally recovered from baboons, rodents, and other mammals. Larval stages of the parasite are dependent upon certain species of freshwater snails in the genus Biomphalaria, which largely determine the parasite's geographical range. How S. mansoni genetic diversity is distributed geographically and among isolates using different hosts has never been examined with DNA sequence data. Here we describe the global phylogeography of S. mansoni using more than 2500 bp of mitochondrial DNA (mtDNA) from 143 parasites collected in 53 geographically widespread localities. Considerable within-species mtDNA diversity was found, with 85 unique haplotypes grouping into five distinct lineages. Geographical separation, and not host use, appears to be the most important factor in the diversification of the parasite. East African specimens showed a remarkable amount of variation, comprising three clades and basal members of a fourth, strongly suggesting an East African origin for the parasite 0.30-0.43 million years ago, a time frame that follows the arrival of its snail host. Less but still substantial variation was found in the rest of Africa. A recent colonization of the New World is supported by finding only seven closely related New World haplotypes which have West African affinities. All Brazilian isolates have nearly identical mtDNA haplotypes, suggesting a founder effect from the establishment and spread of the parasite in this large country. PMID: 16202103 [PubMed - indexed for MEDLINE]

1998

MWANGI, DRMUCHEMIG.  1998.  Periportal fibosis of the liver due to natural or experimental infection with Schistosoma mansoni occurs in the Kenyan baboon. Annals of Tropical Medicine and Parasitology, 92 (2): 187-195. East African Agricultural and Forestry Journal. : EAMJ Abstract
Virology Research Division, Institute of Primate Research, Karen, Nairobi, Kenya. ipr@elci.sasa.unep.no The objective of this study was to investigate the gastro-intestinal (GIT) parasites commonly occurring in captive and wild-trapped (WT) non-human primates (baboons, vervets and Sykes) in Kenya and compare their prevalence. Three hundred and fifteen faecal samples were subjected to a battery of diagnostic tests, namely, direct smear, modified formal ether sedimentation, Kato thick smear, Harada-Mori techniques for parasite detection and culture to facilitate nematode larvae identification. Of these, 203 (64.4%) harboured helminths and 54 (17.1%) had protozoa. The helminth parasites comprised Strongyloides fulleborni 141 (44.8%), Trichuris trichuira 200 (63.5,%), Oesophagostomum sp. 48 (15.2%), Trichostrongylus sp. 73 (23.2%), Enterobius vermicularis 44 (14.0%), Schistosoma mansoni 4/92 (4.3%) and Streptopharagus sp. 68 (21.6%). Protozoan parasites consisted of Entamoeba coli 204 (64.8%), Balantidium coli 127 (40.3%) and Entamoeba histolytica 78 (24.8%). Both WT and colony-borne (CB) primates had similar species of parasites, but higher prevalences of protozoan infection were observed in CB baboons while helminth infections were relatively more common in WT primates. Some of the parasites observed in this study are reported to be zoonotic in various parasitological literatures. Chemoprophylaxis and other managerial practices were believed to be responsible for the lower worm prevalence in CB primates. Similar intervention against protozoa and other agents will not only improve primate health, but also increase safety to animal handlers and colony workers. PMID: 9760061 [PubMed - indexed for MEDLINE]
MWANGI, DRMUCHEMIG.  1998.  Helminth and protozoan gastrointestinal tract parasites in captive and wild-trapped African non-human primates, Veterinary Parasitology, 78:195-201.. East African Agricultural and Forestry Journal. : EAMJ Abstract
Virology Research Division, Institute of Primate Research, Karen, Nairobi, Kenya. ipr@elci.sasa.unep.no The objective of this study was to investigate the gastro-intestinal (GIT) parasites commonly occurring in captive and wild-trapped (WT) non-human primates (baboons, vervets and Sykes) in Kenya and compare their prevalence. Three hundred and fifteen faecal samples were subjected to a battery of diagnostic tests, namely, direct smear, modified formal ether sedimentation, Kato thick smear, Harada-Mori techniques for parasite detection and culture to facilitate nematode larvae identification. Of these, 203 (64.4%) harboured helminths and 54 (17.1%) had protozoa. The helminth parasites comprised Strongyloides fulleborni 141 (44.8%), Trichuris trichuira 200 (63.5,%), Oesophagostomum sp. 48 (15.2%), Trichostrongylus sp. 73 (23.2%), Enterobius vermicularis 44 (14.0%), Schistosoma mansoni 4/92 (4.3%) and Streptopharagus sp. 68 (21.6%). Protozoan parasites consisted of Entamoeba coli 204 (64.8%), Balantidium coli 127 (40.3%) and Entamoeba histolytica 78 (24.8%). Both WT and colony-borne (CB) primates had similar species of parasites, but higher prevalences of protozoan infection were observed in CB baboons while helminth infections were relatively more common in WT primates. Some of the parasites observed in this study are reported to be zoonotic in various parasitological literatures. Chemoprophylaxis and other managerial practices were believed to be responsible for the lower worm prevalence in CB primates. Similar intervention against protozoa and other agents will not only improve primate health, but also increase safety to animal handlers and colony workers. PMID: 9760061 [PubMed - indexed for MEDLINE]
MWANGI, DRMUCHEMIG.  1998.  Schistosoma mansoni ova in urine of children from an endemic area of Kenya: a short report East African Medical Journal 1998 Sept 75(9): 558-559.. East African Agricultural and Forestry Journal. : EAMJ Abstract

Department of Biology, University of New Mexico, Albuquerque, New Mexico 87131 USA. Schistosoma mansoni is the most widespread of the human-infecting schistosomes, present in 54 countries, predominantly in Africa, but also in Madagascar, the Arabian Peninsula, and the Neotropics. Adult-stage parasites that infect humans are also occasionally recovered from baboons, rodents, and other mammals. Larval stages of the parasite are dependent upon certain species of freshwater snails in the genus Biomphalaria, which largely determine the parasite's geographical range. How S. mansoni genetic diversity is distributed geographically and among isolates using different hosts has never been examined with DNA sequence data. Here we describe the global phylogeography of S. mansoni using more than 2500 bp of mitochondrial DNA (mtDNA) from 143 parasites collected in 53 geographically widespread localities. Considerable within-species mtDNA diversity was found, with 85 unique haplotypes grouping into five distinct lineages. Geographical separation, and not host use, appears to be the most important factor in the diversification of the parasite. East African specimens showed a remarkable amount of variation, comprising three clades and basal members of a fourth, strongly suggesting an East African origin for the parasite 0.30-0.43 million years ago, a time frame that follows the arrival of its snail host. Less but still substantial variation was found in the rest of Africa. A recent colonization of the New World is supported by finding only seven closely related New World haplotypes which have West African affinities. All Brazilian isolates have nearly identical mtDNA haplotypes, suggesting a founder effect from the establishment and spread of the parasite in this large country. PMID: 16202103 [PubMed - indexed for MEDLINE]

MWANGI, DRMUCHEMIG.  1998.  The development of Schistosomiasis mansoni in an immulogically na. East African Agricultural and Forestry Journal. : EAMJ Abstract
Division of Vector Borne Diseases, Ministry of Health, Nairobi, Kenya. The relocation of several thousand members of the Kamba tribe from the Kyulu Hills to the Thange valley near Masongaleni in Kenya provides an excellent opportunity to study the development of the immune response to schistosomiasis mansoni in a population with little or no previous experience of the infection. An adjacent, well-established Kamba community with similar patterns of water contact provides a suitable endemic control population. The immigrants were, uniquely, examined shortly after their arrival in the endemic area, while the prevalence of infection was still low. At this time faecal egg counts peaked atypically around 30 years of age. Over the next 12-18 months infection increased rapidly, especially among teenagers, producing a pattern of infection more typical of endemic communities. This substantially narrows estimates of the time required to develop the important determinants of the age-intensity profile, supporting the notion that changes related to age per se, rather than duration of infection, dominate. Age-dependent factors might include behaviour or physiology, including immune response. This paper provides the background for continuing longitudinal studies on the development of immunological responses to this parasite. PMID: 9778634 [PubMed - indexed for MEDLINE]

1997

MWANGI, DRMUCHEMIG.  1997.  Sparganosis in non-human primates. Onderstepoort Journal of Veterinary Research 64:243-244.. East African Agricultural and Forestry Journal. : EAMJ Abstract
Virology Research Division, Institute of Primate Research, Karen, Nairobi, Kenya. ipr@elci.sasa.unep.no The objective of this study was to investigate the gastro-intestinal (GIT) parasites commonly occurring in captive and wild-trapped (WT) non-human primates (baboons, vervets and Sykes) in Kenya and compare their prevalence. Three hundred and fifteen faecal samples were subjected to a battery of diagnostic tests, namely, direct smear, modified formal ether sedimentation, Kato thick smear, Harada-Mori techniques for parasite detection and culture to facilitate nematode larvae identification. Of these, 203 (64.4%) harboured helminths and 54 (17.1%) had protozoa. The helminth parasites comprised Strongyloides fulleborni 141 (44.8%), Trichuris trichuira 200 (63.5,%), Oesophagostomum sp. 48 (15.2%), Trichostrongylus sp. 73 (23.2%), Enterobius vermicularis 44 (14.0%), Schistosoma mansoni 4/92 (4.3%) and Streptopharagus sp. 68 (21.6%). Protozoan parasites consisted of Entamoeba coli 204 (64.8%), Balantidium coli 127 (40.3%) and Entamoeba histolytica 78 (24.8%). Both WT and colony-borne (CB) primates had similar species of parasites, but higher prevalences of protozoan infection were observed in CB baboons while helminth infections were relatively more common in WT primates. Some of the parasites observed in this study are reported to be zoonotic in various parasitological literatures. Chemoprophylaxis and other managerial practices were believed to be responsible for the lower worm prevalence in CB primates. Similar intervention against protozoa and other agents will not only improve primate health, but also increase safety to animal handlers and colony workers. PMID: 9760061 [PubMed - indexed for MEDLINE]

1996

MWANGI, DRMUCHEMIG.  1996.  Jaoko W.G. Muchemi G., Oguya F.O. 1996 Praziquantel side effects during treatment of Schistosoma mansoni infected pupils in Kibwezi, Kenya. East African Medical Journal. 1996 Aug; 73 (8): 499-501. East African Agricultural and Forestry Journal. : EAMJ Abstract
Department of Medical Microbiology, College of Health Sciences, University of Nairobi, Nairobi. Four hundred and thirty six pupils in two primary schools in Kibwezi, Kenya aged between seven and sixteen years and positive for S. mansoni were treated as follows: 320 pupils with a single dose of praziquantel at 40 mg/kg body weight and 116 controls with a placebo. Immediate and delayed side effects of praziquantel were observed. The main side-effects were abdominal pain (36.3%), headache (35.3%) and nausea (13.1%). There was correlation between frequencies of these side-effects and intensity of infection measured as eggs per gram of faeces. Other side-effects included dizziness (9.7%), fever (7.8%), urticaria and bloody diarrhoea. Overall, the side-effects of praziquantel were mild and transient, and did not require any intervention. For ethical reasons, all pupils who served as controls were treated with praziquantel after the study. PMID: 8898462 [PubMed - indexed for MEDLINE]

1994

MWANGI, DRMUCHEMIG.  1994.  Muchemi, G.K.M. (1994), Reservoirs of schistosomiasis in Kenya with specific reference to baboons. Proceedings of the Symposium on epidemiology and Control of Schistosomiasis, KEMRI./JICA, October 1994, Nairobi, Kenya. East African Agricultural and Forestry Journal. : EAMJ Abstract
Department of Medical Microbiology, College of Health Sciences, University of Nairobi, Nairobi. Four hundred and thirty six pupils in two primary schools in Kibwezi, Kenya aged between seven and sixteen years and positive for S. mansoni were treated as follows: 320 pupils with a single dose of praziquantel at 40 mg/kg body weight and 116 controls with a placebo. Immediate and delayed side effects of praziquantel were observed. The main side-effects were abdominal pain (36.3%), headache (35.3%) and nausea (13.1%). There was correlation between frequencies of these side-effects and intensity of infection measured as eggs per gram of faeces. Other side-effects included dizziness (9.7%), fever (7.8%), urticaria and bloody diarrhoea. Overall, the side-effects of praziquantel were mild and transient, and did not require any intervention. For ethical reasons, all pupils who served as controls were treated with praziquantel after the study. PMID: 8898462 [PubMed - indexed for MEDLINE]

1992

MWANGI, DRMUCHEMIG.  1992.  Muchemi, G.K.M. (1992) Baboons as maintenance hosts of human schistosomiasis in Kenya. Ph. D. thesis University of Liverpool, U.K. East African Agricultural and Forestry Journal. : EAMJ Abstract
Department of Medical Microbiology, College of Health Sciences, University of Nairobi, Nairobi. Four hundred and thirty six pupils in two primary schools in Kibwezi, Kenya aged between seven and sixteen years and positive for S. mansoni were treated as follows: 320 pupils with a single dose of praziquantel at 40 mg/kg body weight and 116 controls with a placebo. Immediate and delayed side effects of praziquantel were observed. The main side-effects were abdominal pain (36.3%), headache (35.3%) and nausea (13.1%). There was correlation between frequencies of these side-effects and intensity of infection measured as eggs per gram of faeces. Other side-effects included dizziness (9.7%), fever (7.8%), urticaria and bloody diarrhoea. Overall, the side-effects of praziquantel were mild and transient, and did not require any intervention. For ethical reasons, all pupils who served as controls were treated with praziquantel after the study. PMID: 8898462 [PubMed - indexed for MEDLINE]

1990

Suleman, MA;, Muchemi G;, Wango EO.  1990.  Survival of the species..
MWANGI, DRMUCHEMIG.  1990.  Muchemi, G. (1990), Monkeys suffer from bilharzia too. Swara (East African Wildlife Society) 13 (3):23. East African Agricultural and Forestry Journal. : EAMJ Abstract
Department of Medical Microbiology, College of Health Sciences, University of Nairobi, Nairobi. Four hundred and thirty six pupils in two primary schools in Kibwezi, Kenya aged between seven and sixteen years and positive for S. mansoni were treated as follows: 320 pupils with a single dose of praziquantel at 40 mg/kg body weight and 116 controls with a placebo. Immediate and delayed side effects of praziquantel were observed. The main side-effects were abdominal pain (36.3%), headache (35.3%) and nausea (13.1%). There was correlation between frequencies of these side-effects and intensity of infection measured as eggs per gram of faeces. Other side-effects included dizziness (9.7%), fever (7.8%), urticaria and bloody diarrhoea. Overall, the side-effects of praziquantel were mild and transient, and did not require any intervention. For ethical reasons, all pupils who served as controls were treated with praziquantel after the study. PMID: 8898462 [PubMed - indexed for MEDLINE]

1989

MWANGI, DRMUCHEMIG.  1989.  Eley, R.M. Strum, S.C., Muchemi, G. and Reid, G.D.F. 1989. Nutrition, body condition, activity patterns and parasitism of free-ranging troops of olive baboons (Papio anubis) in Kenya. American Journal of Primatology 18:209-219. East African Agricultural and Forestry Journal. : EAMJ Abstract
Department of Medical Microbiology, College of Health Sciences, University of Nairobi, Nairobi. Four hundred and thirty six pupils in two primary schools in Kibwezi, Kenya aged between seven and sixteen years and positive for S. mansoni were treated as follows: 320 pupils with a single dose of praziquantel at 40 mg/kg body weight and 116 controls with a placebo. Immediate and delayed side effects of praziquantel were observed. The main side-effects were abdominal pain (36.3%), headache (35.3%) and nausea (13.1%). There was correlation between frequencies of these side-effects and intensity of infection measured as eggs per gram of faeces. Other side-effects included dizziness (9.7%), fever (7.8%), urticaria and bloody diarrhoea. Overall, the side-effects of praziquantel were mild and transient, and did not require any intervention. For ethical reasons, all pupils who served as controls were treated with praziquantel after the study. PMID: 8898462 [PubMed - indexed for MEDLINE]
MWANGI, DRMUCHEMIG.  1989.  Muchemi G., (1989). The use of wild carnivores and wild antelopes in the study of Taeniasis and cysticercosis. Proceeding of the First East African Conference on Laboratory Animal Science, November, 1989, Nairobi, Kenya. East African Agricultural and Forestry Journal. : EAMJ Abstract
Department of Medical Microbiology, College of Health Sciences, University of Nairobi, Nairobi. Four hundred and thirty six pupils in two primary schools in Kibwezi, Kenya aged between seven and sixteen years and positive for S. mansoni were treated as follows: 320 pupils with a single dose of praziquantel at 40 mg/kg body weight and 116 controls with a placebo. Immediate and delayed side effects of praziquantel were observed. The main side-effects were abdominal pain (36.3%), headache (35.3%) and nausea (13.1%). There was correlation between frequencies of these side-effects and intensity of infection measured as eggs per gram of faeces. Other side-effects included dizziness (9.7%), fever (7.8%), urticaria and bloody diarrhoea. Overall, the side-effects of praziquantel were mild and transient, and did not require any intervention. For ethical reasons, all pupils who served as controls were treated with praziquantel after the study. PMID: 8898462 [PubMed - indexed for MEDLINE]

1987

MWANGI, DRMUCHEMIG.  1987.  Binhazim, A.A., Githure, J.I., Muchemi G.K. and Reid, G.D.F. 1987. Isolation of Leishmania major from a naturally infected vervet monkey (Cercopithecus aethiops) caught in Kiambu district, Kenya. Journal of Parasitology 73 (6): 1278-1279. East African Agricultural and Forestry Journal. : EAMJ Abstract
Department of Medical Microbiology, College of Health Sciences, University of Nairobi, Nairobi. Four hundred and thirty six pupils in two primary schools in Kibwezi, Kenya aged between seven and sixteen years and positive for S. mansoni were treated as follows: 320 pupils with a single dose of praziquantel at 40 mg/kg body weight and 116 controls with a placebo. Immediate and delayed side effects of praziquantel were observed. The main side-effects were abdominal pain (36.3%), headache (35.3%) and nausea (13.1%). There was correlation between frequencies of these side-effects and intensity of infection measured as eggs per gram of faeces. Other side-effects included dizziness (9.7%), fever (7.8%), urticaria and bloody diarrhoea. Overall, the side-effects of praziquantel were mild and transient, and did not require any intervention. For ethical reasons, all pupils who served as controls were treated with praziquantel after the study. PMID: 8898462 [PubMed - indexed for MEDLINE]

1986

MWANGI, DRMUCHEMIG.  1986.  Eley, R.M., Strum S. and Muchemi, G. 1986. Nutritional effects upon physical condition of three free-ranging troops of baboons in Gilgil, Kenya. Primate Report 14:136. East African Agricultural and Forestry Journal. : EAMJ Abstract
Department of Medical Microbiology, College of Health Sciences, University of Nairobi, Nairobi. Four hundred and thirty six pupils in two primary schools in Kibwezi, Kenya aged between seven and sixteen years and positive for S. mansoni were treated as follows: 320 pupils with a single dose of praziquantel at 40 mg/kg body weight and 116 controls with a placebo. Immediate and delayed side effects of praziquantel were observed. The main side-effects were abdominal pain (36.3%), headache (35.3%) and nausea (13.1%). There was correlation between frequencies of these side-effects and intensity of infection measured as eggs per gram of faeces. Other side-effects included dizziness (9.7%), fever (7.8%), urticaria and bloody diarrhoea. Overall, the side-effects of praziquantel were mild and transient, and did not require any intervention. For ethical reasons, all pupils who served as controls were treated with praziquantel after the study. PMID: 8898462 [PubMed - indexed for MEDLINE]

1985

MWANGI, DRMUCHEMIG.  1985.  Harrison L.J.S., Muchemi, G.K.M. and Sewel, M.M.H.1985. Attempted infection of calves with cysticerci of Taenia crocutae and their subsequent serological response. Research in Veterinary Science 38:383-385. East African Agricultural and Forestry Journal. : EAMJ Abstract
Department of Medical Microbiology, College of Health Sciences, University of Nairobi, Nairobi. Four hundred and thirty six pupils in two primary schools in Kibwezi, Kenya aged between seven and sixteen years and positive for S. mansoni were treated as follows: 320 pupils with a single dose of praziquantel at 40 mg/kg body weight and 116 controls with a placebo. Immediate and delayed side effects of praziquantel were observed. The main side-effects were abdominal pain (36.3%), headache (35.3%) and nausea (13.1%). There was correlation between frequencies of these side-effects and intensity of infection measured as eggs per gram of faeces. Other side-effects included dizziness (9.7%), fever (7.8%), urticaria and bloody diarrhoea. Overall, the side-effects of praziquantel were mild and transient, and did not require any intervention. For ethical reasons, all pupils who served as controls were treated with praziquantel after the study. PMID: 8898462 [PubMed - indexed for MEDLINE]

1984

MWANGI, DRMUCHEMIG.  1984.  Allsopp, B.A. MacPherson, C.N.L., Jones, A. and Muchemi, G.K. 1984. Techniques for the identification of gastrointestinal helminths obtained from carnivores in Kenya. Proceedings of the KEMRI/KETRI Conference. Feb 1984. Nairobi, Kenya. East African Agricultural and Forestry Journal. : EAMJ Abstract
Department of Medical Microbiology, College of Health Sciences, University of Nairobi, Nairobi. Four hundred and thirty six pupils in two primary schools in Kibwezi, Kenya aged between seven and sixteen years and positive for S. mansoni were treated as follows: 320 pupils with a single dose of praziquantel at 40 mg/kg body weight and 116 controls with a placebo. Immediate and delayed side effects of praziquantel were observed. The main side-effects were abdominal pain (36.3%), headache (35.3%) and nausea (13.1%). There was correlation between frequencies of these side-effects and intensity of infection measured as eggs per gram of faeces. Other side-effects included dizziness (9.7%), fever (7.8%), urticaria and bloody diarrhoea. Overall, the side-effects of praziquantel were mild and transient, and did not require any intervention. For ethical reasons, all pupils who served as controls were treated with praziquantel after the study. PMID: 8898462 [PubMed - indexed for MEDLINE]

1982

MWANGI, DRMUCHEMIG.  1982.  Stevenson, P., Muchemi G. and Karstad, L. 1982 Taenia saginata infection in East African antelopes. Veterinary Record 111:322. East African Agricultural and Forestry Journal. : EAMJ Abstract
Department of Medical Microbiology, College of Health Sciences, University of Nairobi, Nairobi. Four hundred and thirty six pupils in two primary schools in Kibwezi, Kenya aged between seven and sixteen years and positive for S. mansoni were treated as follows: 320 pupils with a single dose of praziquantel at 40 mg/kg body weight and 116 controls with a placebo. Immediate and delayed side effects of praziquantel were observed. The main side-effects were abdominal pain (36.3%), headache (35.3%) and nausea (13.1%). There was correlation between frequencies of these side-effects and intensity of infection measured as eggs per gram of faeces. Other side-effects included dizziness (9.7%), fever (7.8%), urticaria and bloody diarrhoea. Overall, the side-effects of praziquantel were mild and transient, and did not require any intervention. For ethical reasons, all pupils who served as controls were treated with praziquantel after the study. PMID: 8898462 [PubMed - indexed for MEDLINE]
MWANGI, DRMUCHEMIG.  1982.  Muchemi G.K.M. (1982). A study of Muscle Cysticercosis in Wild animals of Kenya. MSc thesis University of Guelph, Ontario Canada. East African Agricultural and Forestry Journal. : EAMJ Abstract
Department of Medical Microbiology, College of Health Sciences, University of Nairobi, Nairobi. Four hundred and thirty six pupils in two primary schools in Kibwezi, Kenya aged between seven and sixteen years and positive for S. mansoni were treated as follows: 320 pupils with a single dose of praziquantel at 40 mg/kg body weight and 116 controls with a placebo. Immediate and delayed side effects of praziquantel were observed. The main side-effects were abdominal pain (36.3%), headache (35.3%) and nausea (13.1%). There was correlation between frequencies of these side-effects and intensity of infection measured as eggs per gram of faeces. Other side-effects included dizziness (9.7%), fever (7.8%), urticaria and bloody diarrhoea. Overall, the side-effects of praziquantel were mild and transient, and did not require any intervention. For ethical reasons, all pupils who served as controls were treated with praziquantel after the study. PMID: 8898462 [PubMed - indexed for MEDLINE]

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