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S PROFIGONSANGWASHIBAIRO. "Effects of four biopesticides on the spider mite Tetranychus evansi. In press. Phytophaga, XIV: 1-8.". In: Paper presented in the International Edible Legume (IELC)/4th World Cowpea Congress held on 17 . Taylor & Francis; 2005. Abstract
Normal 0 false false false MicrosoftInternetExplorer4 st1:*{behavior:url(#ieooui) } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} Hepatocellular carcinoma results when cancerous cells are localized in the liver. It is distributed globally with high prevalence in sub-Saharan African, southern Asia, China and Japan. Diagnosis is experimental and in many cases inaccurate due to unreliability of markers. Prognosis is poor and the cost of treatment prohibitive. Conventional radiation and chemotherapy lead to loss of hair, fertility and general weakening of the body`s immune system increasing a patient`s risk to infection. These observations underscore the need for improved, or additional methods of cancer diagnosis and management. We investigated the effect of polysaccharide rich Pleurotus pulmonarius fruit body extracts on progression of chemically induced hepatocellular carcinoma in CBA mice. Addition of Pleurotus pulmonarius extracts in diet delayed progression of carcinogenesis suggesting   that these extracts may be useful as   adjuvants to conventional cancer therapies.   Key words: carcinogenesis; mice; mushroom extracts; pleurotus pulmunarius   Corresponding author: Ms Carolyne Wasonga, Department of Biochemistry, University of Nairobi, P.O. Box 30197, Nairobi,  Kenya. E-mail: carox27@yahoo.ca     Charles O.A. Omwandho, Susanne E. Gruessner, John Falconer, Hans-R Tinneberg, Timothy K. Roberts. IS OVINE PLACENTAL IGG TOXIC TO HUMAN PERIPHERAL BLOOD NATURAL KILLER CELLS?
S PROFIGONSANGWASHIBAIRO. "Effects of temperature on germination of three pigeon pea (Cajanus cajan) genotypes. Discovery and Innovation, 7: 283-287.". In: Paper submitted in the 3rd International Weed Science Congress in June 2000 at Foz du Iguasu, Brazil. Taylor & Francis; 1995. Abstract
Normal 0 false false false MicrosoftInternetExplorer4 st1:*{behavior:url(#ieooui) } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} Hepatocellular carcinoma results when cancerous cells are localized in the liver. It is distributed globally with high prevalence in sub-Saharan African, southern Asia, China and Japan. Diagnosis is experimental and in many cases inaccurate due to unreliability of markers. Prognosis is poor and the cost of treatment prohibitive. Conventional radiation and chemotherapy lead to loss of hair, fertility and general weakening of the body`s immune system increasing a patient`s risk to infection. These observations underscore the need for improved, or additional methods of cancer diagnosis and management. We investigated the effect of polysaccharide rich Pleurotus pulmonarius fruit body extracts on progression of chemically induced hepatocellular carcinoma in CBA mice. Addition of Pleurotus pulmonarius extracts in diet delayed progression of carcinogenesis suggesting   that these extracts may be useful as   adjuvants to conventional cancer therapies.   Key words: carcinogenesis; mice; mushroom extracts; pleurotus pulmunarius   Corresponding author: Ms Carolyne Wasonga, Department of Biochemistry, University of Nairobi, P.O. Box 30197, Nairobi,  Kenya. E-mail: carox27@yahoo.ca     Charles O.A. Omwandho, Susanne E. Gruessner, John Falconer, Hans-R Tinneberg, Timothy K. Roberts. IS OVINE PLACENTAL IGG TOXIC TO HUMAN PERIPHERAL BLOOD NATURAL KILLER CELLS?
S PROFKIGONDUCHRISTINE. "Early perinatal outcome in cases delivered through Caesarian section following clinical diagnosis of severe foetal distress at Kenyatta National Hospital. East Afr Med J. 2006 May;83(5):250-8.". In: East Afr Med J. 2006 May;83(5):250-8. uon press; 2006. Abstract
OBJECTIVES: To determine the value of clinical foetal distress in predicting early perinatal outcome. DESIGN: Prospective cohort study. SETTING: Kenyatta National Hospital. SUBJECTS: Fifty eight newborns delivered via Caesarian section with a diagnosis of clinical foetal distress were compared with another group of 58 newborns delivered similarly, but without clinical foetal distress. RESULTS: Newborn acidemia was found in 71% of newborns with clinical foetal distress in contrast to 17% in newborns without foetal distress. Low Apgar score at one minute was noted in about 59% of newborns with foetal distress compared with 31% in newborns without foetal distress. Similarly, 24.1% of neonates with clinical foetal distress had low Apgar score at five minutes compared with 3.4% in those without foetal distress. Thirty one percent of newborns with clinical foetal distress were admitted to newborn unit for more than 24 hours due to respiratory distress or birth asphyxia compared to 17% of those without foetal distress. The incidence of morbidity and or mortality in newborns exposed to foetal distress was twice the one of newborns without foetal distress. CONCLUSION: The results obtained in this study agreed with those who consider intrapartum passage of meconeum and abnormal foetal heart rate and rhythm to signify clinical foetal distress that carries bad prognostic outcome. These two parameters should still be used to indicate foetal distress which requires immediate institution of supportive therapy and immediate delivery.
S PROFKIGONDUCHRISTINE. "Mutungi A.K., Sanghvi H.C.G., Ojwang S.B.O., Sinei S.K. Sekadde-Kigondu C.B. Utilization of maternal and peri-natal Outcome of Twins Delivered at Two Public Hospitals in Nairobi, Kenya. J. Obstet. Gynaecol, E.C. Africa Vol 15 (5) 20, 1999.". In: J. Obstet. Gynaecol, E.C. Africa Vol 15 (5) 20, 1999. uon press; 1999. Abstract
OBJECTIVE: To determine if women receiving intrauterine devices (IUCDs) outside of menses have an acceptable rate of insertion problems and subsequent IUCD-related complications. DESIGN: Cross-sectional and prospective cohort study of insertions at times other than during menses. SETTING: The study was carried out in two government family planning (FP) clinics in Nairobi, Kenya. SUBJECTS: After appropriate pre-test and post-test HIV counselling, 1686 women requesting IUCDs at two FP clinics between 1994 and 1995 in Nairobi were enrolled at baseline into a study examining the effect of human immuno-deficiency virus (HIV) infection on IUCD-related complications. Six hundred and forty nine women (156 HIV-infected and 493 HIV-uninfected) were selected for the four month follow up study. They were classified according to their menstrual cycle status at time of IUCD insertion. MAIN OUTCOME MEASURES: Problems at the time of insertion (pain, bleeding, immediate expulsion) and IUCD-related complications through four months. RESULTS: Rates of immediate insertion problems were low in the women who had insertions during menses (7.0%), outside of menses (4.0%) or had oligomenorrhea/amenorrhea (2.6%). The adjusted odds ratios for IUCD insertion problems outside of menses and in oligomenorrhea/amenorrhea (versus women with insertion during menses) were 0.54 (95 % CI 0.18-1.59) and 0.39 (95% CI 0.12-1.29) respectively. IUCD-related complications were higher in the oligomenorrhea/amenorrhea (11.5%) or insertion outside of menses (6.9%), than the within menses (4.3%) groups. However, the differences were not statistically significant. Adjusted odds ratios for IUCD outside of menses and oligomenorrhoea/amenorrhea groups were 1.65 (95% CI 0.21-12.91) and 2.72 (95% CI 0.34-21.71) respectively. CONCLUSION: The results confirm that the IUCD can be safely inserted outside of menses with minimal insertion difficulties and subsequent complications. Availability of IUCDs outside of menses may enhance IUCD acceptance in Kenya and create better opportunity for visual screening of the cervix for sexually transmitted infections.
S PROFMASINDEMICHAEL. "Paschke, C., Masinde, S., Gaeckle, H. Provoked preference test .". In: E. African Journal of Ophthalmology 11: 48 , 2002.; 2002. Abstract
OBJECTIVE: To determine the prevalence of Xerophthalmia among Kenyan children aged four to seven years in high risk using Conjuctival Impression Cytology and transfer. DESIGN: A cross sectional community based study. SETTING: Mathare slum in Nairobi and Tiva/Ithiani area of Kitui. SUBJECTS: Children aged four to seven years residing in the above areas were assessed for both clinical and cytological features of vitamin A deficiency. RESULTS: Of the 342 children included in this study, 316 (92.0%) were normal, five (1.5%) had XN, 19 (5.9% had XIA and two (0.6%) had XIB. No signs of corneal Xerophthalmia were seen in this study. Conjuctival impression cytology and transfer (CICT) was used to asses for squamous metaplastic changes associated with Vitamin A deficiency (VAD). Seventy five (23.1%) of the children were normal by CICT while 249 (76.9%) were abnormal. In comparing the two areas of study, only 13.2% of the children in Mathare had normal CICT compared to 50% in Kitui. For each of the age groups studied there was significant difference between the two areas with children from Mathare being more deficient than those from Kitui. CONCLUSION: VAD is a significant health problem in the high risk areas assessed by CICT in this study.
S PROFKIGONDUCHRISTINE. "Sinei SK, Fortney JA, Kigondu CS, Feldblum PJ, Kuyoh M, Allen MY, Glover LH. Contraceptive use and HIV infection in Kenyan family planning clinic attenders.Int J STD AIDS. 1996 Jan-Feb;7(1):65-70.". In: Int J STD AIDS. 1996 Jan-Feb;7(1):65-70. uon press; 1996. Abstract
Department of Obstetrics and Gynaecology, University of Nairobi, Kenya. This pilot study aimed to determine the feasibility of a larger study of contraception and risk of HIV infection in women. We also measured risk factors for and occurrence of HIV infection in the participants. A cohort of 1537 seronegative women attending a family planning clinic in Nairobi, Kenya was enrolled and followed for up to 12 months per woman. HIV testing was done quarterly. A nested case-control analysis was done with seroconverting women (cases) and 3 matched controls per case, who had detailed interviews and received physical examinations and STD tests. The prevalence of HIV at enrollment was 6.1%; seropositive women were excluded from further analysis. The 12-month life-table cumulative incidence of HIV was 2.1 per 100 women (95% confidence interval [CI] 1.1-3.2). In the nested case-control analysis (17 cases and 51 controls), the crude odds ratio of HIV infection comparing oral contraceptive (OC) users with other women was 3.5 (95%) CI 0.8-21.5), which persisted after control for single confounders at a time. The putative association between OC use sand HIV infection is critical to public health policy, yet no study has been conducted specifically to measure it, yielding weak and conflicting evidence. We intend to conduct a larger study with a similar design as the current pilot study, which confirmed the feasibility of a more definitive project.
S PROFOLIECHJOSEPH. "The AIDS situation and its containment.". In: East Afr Med J. 1990 Jul;67(7 Suppl. PROF.J.S.OLIECH; 1990. Abstract
No abstract available yet
S PROFKIGONDUCHRISTINE. "Mati J.K.G., Sekadde-Kigondu C.B. Principal investigators for Nairobi, Kenya Towards more objective in diagnosis and management of male fertility. Results from multicentre study Int. J. Andrology Supp. (7), 1987.". In: Results from multicentre study Int. J. Andrology Supp. (7), 1987. uon press; 1987. Abstract

PIP: The effects of the triphasic oral contraceptive (OC) ethinyl estradiol (EE) and levonorgestrel (LNG) on lipid and lipoprotein metabolism were evaluated in 97 black Kenyan women. Subjects were recruited from the Family Planning Clinic and were followed for 12 months. There was an increase in fasting levels of total cholesterol. These changes were not statistically significant. However, the triglyceride increase was statistically significant at 9 months and 12 months (p0.05). The high density cholesterol remained unchanged. Thus, this triphasic OC was found to have minimal effect on lipid and lipoprotein metabolism. author's modified

S PROFKIGONDUCHRISTINE. "Thuo S.T.N., Maina F.W., Sekadde-Kigondu C.B., Lequin R.M., Mati J.K.G.J. Obstet. Gynaecol. E. Central Afr. 2:15, 1983. Assessment of flat oral glucose tolerance tests.". In: J Obstet Gynaecol East Cent Africa. 1983 Mar;2(1):23-6. uon press; 1983. Abstract
PIP: Menstrual blood loss (MBL) was evaluated in 74 nulliporous Kenyan women aged between 20 and 27 years. The hemoglobin levels were all in normal range with the mean of 13.65 +or- 0.8, 13.84 +or- 1.2 and 13.04 +or- 1.2 g/100 ml respectively in 3 populations. The MBL was comparable in the 3 populations with the mean of 35.1 +or- 12.6, 30.6 +or- 8.7 and 32.2 +or- 9.4 ml respectively. There was no difference of statistical significance between the 2 periods studied per each individual. This study objectively assesses the menstrual blood loss in 3 population groups–2 urban and 1 rural. The data can be used to evaluate menstrual blood loss before and after initiation of various contraceptives used in Kenya. Subjects were volunteers who were not on any contraception except barrier or natural rhythm methods, not under psychological stress and who exhibited normal physical female characteristics on examination. Those who wished to drop out, became pregnant or desired contraception, were excluded. The study confirms the individual constancy of the menstrual blood loss in this population. This has important practical implications since a single determination of the menstrual blood loss may be a fairly good expression for the average blood loss in a woman. The immediate effect of various treatments such as IUD insertion or oral contraceptives on the MBL may easily be evaluated quantitatively by measurements in consecutive periods using only 1 period as a control. The quick method can be easily used in evaluating pathological conditions e.g. iron-deficiency due to heavy bleeding, IUD-associated hemorrhage, menorrhagia and uterine fibroid.
S PROFKIGONDUCHRISTINE. "Contraceptives, clients and the medical profession. Kenya Nurs J. 1972 Jun;1(1):48-50.". In: Kenya Nurs J. 1972 Jun;1(1):48-50. uon press; 1972. Abstract

PIP: Masturbatory semen specimen from 49 fertile Black African males in Kenya whose wives were pregnant was obtained after at least 3 days of abstinence for the analysis of parameters which included volume motility, vitality, sperm concentration, pH, fructose and acid phosphatase levels. About 1/2 the spermatozoa was actively progressive in motility, while 40% was nonmotile. Vitality in the 1st hour revealed that 81.4% of the sperm was alive. About 90% of the semen specimens had more than 40% idea forms of spermatozoa. Spermatozoal abnormalities were a frequent feature. There was no correlation between age and the testicular volume, but seminal fluid volume and sperm density tended to decrease with age. Serum levels of Follicle Stimulating Hormone, Luteinizing Hormone, Prolactin and Testosterone were determined in the subjects' sera, enabling the establishment of reference values for these parameters in African Kenyan males.

S MRWANYAMAJOSEPH. THE MYSTERIOUS KILLER. Nairobi: Africawide Network; 2001.Website
S OB, A O’o J. "SEX DIFFERENCES IN DIAMETER OF THE CORONARY SINUS OSTIUM: CORRELATION WITH WEIGHT OF THE HEART." Anatomy Journal of Africa.. 2017;6(1):862-866. Abstractsex_differences_in_diameter_of_the_coronary_sinus.pdfWebsite

Diameter of the coronary sinus ostium is important in the designing of cannulation devices used in cardiac
resynchronization therapy and percutaneous mitral valve annuloplasty. Population variation of the
diameter may account for the failure rate of these procedures. Studies of the coronary sinus ostium from
African populations are scarce and altogether absent for Kenya. Therefore, this study aimed at
determining sex differences in the diameter of coronary sinus ostium and its correlation with the weight
of the heart. Seventy-four hearts of adult black Kenyans [43 male, 31 females; age range 20 – 70 years]
obtained during autopsy at the Department of Human Anatomy, University of Nairobi, Kenya were
weighed. The coronary sinus ostium was identified and its transverse and supero-inferior diameters
measured in millimeters. The measurements were analyzed using SPSS version 17. Sex comparison was
established using student’s t test. Association between diameter and heart weight was established using
Pearson’s correlation test and considered significant at a p-value of ≤0.05. Data were presented using
scatter plots. Transverse and supero-inferior diameters of the ostium were 11.04±1.88mm and
9.50±1.80mm respectively. The mean diameter was 10.27 mm. These correlated positively with weight
of the heart. When corrected for weight of the hearts, the transverse and supero-inferior diameters were
larger in females (0.042 and 0.036 respectively) than in males (0.034 and 0.03 respectively). The
diameter of coronary sinus ostium is larger in females and shows positive correlation with weight of the
heart. These data should be considered during design and use of cardiac devices introduced through
the coronary sinus.

S PROFIGONSANGWASHIBAIRO. "Postharvest moisture loss characteristics of carrot (Daucus carota L.) cultivars during short-term storage. Scientia Horticulturae, 71: 1-12.". In: Paper submitted in the 3rd International Weed Science Congress in June 2000 at Foz du Iguasu, Brazil. Taylor & Francis; 1997. Abstract
Normal 0 false false false MicrosoftInternetExplorer4 st1:*{behavior:url(#ieooui) } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} Hepatocellular carcinoma results when cancerous cells are localized in the liver. It is distributed globally with high prevalence in sub-Saharan African, southern Asia, China and Japan. Diagnosis is experimental and in many cases inaccurate due to unreliability of markers. Prognosis is poor and the cost of treatment prohibitive. Conventional radiation and chemotherapy lead to loss of hair, fertility and general weakening of the body`s immune system increasing a patient`s risk to infection. These observations underscore the need for improved, or additional methods of cancer diagnosis and management. We investigated the effect of polysaccharide rich Pleurotus pulmonarius fruit body extracts on progression of chemically induced hepatocellular carcinoma in CBA mice. Addition of Pleurotus pulmonarius extracts in diet delayed progression of carcinogenesis suggesting   that these extracts may be useful as   adjuvants to conventional cancer therapies.   Key words: carcinogenesis; mice; mushroom extracts; pleurotus pulmunarius   Corresponding author: Ms Carolyne Wasonga, Department of Biochemistry, University of Nairobi, P.O. Box 30197, Nairobi,  Kenya. E-mail: carox27@yahoo.ca     Charles O.A. Omwandho, Susanne E. Gruessner, John Falconer, Hans-R Tinneberg, Timothy K. Roberts. IS OVINE PLACENTAL IGG TOXIC TO HUMAN PERIPHERAL BLOOD NATURAL KILLER CELLS?
S PROFMASINDEMICHAEL, R. DRILAKODUNERA. "D.R. Ilako, M. Bhaiji, M.S. Masinde Immunoglobulin Levels in Tears M.Med Thesis 1991.". In: M.Med Thesis 1991. Philosophical Issues Invoked by Shona People; 1991. Abstract
OBJECTIVES: To estimate the prevalence of active trachoma (TF) in children aged one to nine years and potentially blinding trachoma (TT) in adults aged 15 years and older in six known trachoma-endemic districts in Kenya. DESIGN: Community based survey. SETTING: Six known trachoma endemic districts in Kenya (Samburu, Narok, West Pokot, Kajiado Baringo and Meru North). SUBJECTS: A total of 6,982 children aged one to nine years and 8,045 adults aged 15 years and older were randomly selected in a two stage random cluster sampling method: Twenty sub-locations (clusters) per district and three villages per sub-location were randomly selected. Eligible children and adults were enumerated and examined for signs of trachoma. RESULTS: Blinding trachoma was found to be a public health problem in all the surveyed districts. Active trachoma was a district wide public health problem in four districts (Samburu, Narok, West Pokot and Kajiado) and only in some of the sub-locations of the other two (Baringo and Meru North). CONCLUSIONS: There is need for district trachoma control programmes preferably using the WHO recommended SAFE strategy in all the surveyed districts. Extrapolation of these survey results to the entire country could not be justified. There is need to survey the remaining 12 suspected endemic districts in Kenya.
S PROFKIGONDUCHRISTINE. "Kokonya D.A., Sinei S.K.A., Sekadde-Kigondu C.B., Morrison C.S., Kwok C, and Waner D.H. Experience with IUCD insertion outside Of menses in Kenya, E.A. Med J. 77 (7) 369, 2000.". In: E.A. Med J. 77 (7) 369, 2000. uon press; 2000. Abstract
Reproductive Biology Unit, Department of Animal Physiology, University of Nairobi, Kenya. dochiel@kisian.mimcom.net The presence of human immunodeficiency virus (HIV) in genital secretions is regarded as a risk factor for sexual and perinatal transmission of HIV. A better understanding of correlates of genital shedding of HIV is crucial to the development of effective strategies against transmission of this virus. Events during menstrual cycle are likely to influence local immune responses and viral load in genital secretions, and hence determine susceptibility to HIV or efficiency of virus transmission. We report, in this study, preliminary findings on the relationship of menstrual cycle to genital mucosal and systemic immunity in female olive baboons (Papio anubis) experimentally inoculated with simian/human immunodeficiency virus (SHIV)89.6P.
S PROFKIGONDUCHRISTINE. "Sekadde-Kigondu, C.B., Mwathe,E.G., Ruminjo, J.K., Nichols, D. et al. Discontinuation of Depo-provera, IUCD, and Combined Pills, E.A. Med.J. 73:786, 1996.". In: E.A. Med.J. 73:786, 1996. uon press; 1996. Abstract
This pilot study aimed to determine the feasibility of a larger study of contraception and risk of HIV infection in women. We also measured risk factors for and occurrence of HIV infection in the participants. A cohort of 1537 seronegative women attending a family planning clinic in Nairobi, Kenya was enrolled and followed for up to 12 months per woman. HIV testing was done quarterly. A nested case-control analysis was done with seroconverting women (cases) and 3 matched controls per case, who had detailed interviews and received physical examinations and STD tests. The prevalence of HIV at enrollment was 6.1%; seropositive women were excluded from further analysis. The 12-month life-table cumulative incidence of HIV was 2.1 per 100 women (95% confidence interval [CI] 1.1-3.2). In the nested case-control analysis (17 cases and 51 controls), the crude odds ratio of HIV infection comparing oral contraceptive (OC) users with other women was 3.5 (95%) CI 0.8-21.5), which persisted after control for single confounders at a time. The putative association between OC use sand HIV infection is critical to public health policy, yet no study has been conducted specifically to measure it, yielding weak and conflicting evidence. We intend to conduct a larger study with a similar design as the current pilot study, which confirmed the feasibility of a more definitive project.
S DRKARANJAHDOMINIC. "Karanja D. S .". In: The Limnology, Climatology and Palaeoclimatology of the East African Lakes pp. 413-431, Gordon and Breach Publishers, Amsterdam. June 1996 b) Books Reference Date. Earthscan, London. 978-1-84407-469-3 (*); 1976. Abstract
n/a
S PROFKIGONDUCHRISTINE. "Qureshi,Z.P., Sekadde-Kigondu, C,B. A Survey to Determine the Knowledge , Attitudes and Practice of Family Planning Amongst the Nursing Staff at Kenyatta National Hospital. J. Obstet. Gynaecol E.and Centr. Afric 9:49, 1991.". In: J. Obstet. Gynaecol E.and Centr. Afric 9:49, 1991. uon press; 1991. Abstract
Forty females, age 14 to 35 years (mean 28.6 years) with chronic renal failure (CRF) were included in the study. Their menstrual patterns were noted. The function of their hypothalamo-pituitary-ovarian axis was assessed by the serum levels of follicle stimulating hormone (FSH), Luteinising hormone (LH), prolactin (PrL), estradiol (E2) and progesterone (P) at different phases of the menstrual cycle in patients who continued to have normal menses (Group 1) and at weekly intervals for six weeks in patients with menstrual disturbances (Group II). The mean hormone levels during the initial contact Luteal phase in group I were FSH 12.0 IU/L (N, 1.0-3.0 IU/L), LH 1.8IU/L (N 1.5-101U/L), PrL 652mIU/L (N, 100-600 mIU/L) mE2 160 pmol/L (N 400-1400 pmol/L) and P5 nmol/L (N 14-60 nmol/L) for group I. Corresponding values for group II were 1.2, 10.3, 250, 600 and 3.0 in relevant units. All patients (fourteen) with end stage renal disease (ESRD) had amenorrhoae. On the other hand, most patients with stable CRF (22/26) had normal menses. Following initiation of therapy (conservative or dialytic), there was no significant alteration in the hormonal profile or menstrual pattern. We conclude that other factors apart from the hormonal imbalances, may be responsible for the menstrual disturbances noted in patients with CRF.
S PROFOLIECHJOSEPH. "Carcinoma of thyroid at KNH Assoc. of Surgeons of E.A. proceedings Dec. 1978.". In: East Afr Med J. 1979 Jan;56(1):40-1. PROF.J.S.OLIECH; 1978. Abstract

No abstract available yet.ABSTRACT.

This a report of thirty patients who presented at Kenyatta National Hospital( KNH),Uinversity Of Nairobi (UON) during the three year period January 1974-December 1976 with a diagnosis of thyroid carcinoma.Fourteen had follicular, eight papiilary,four anaplastic,and four medullary types.
Eight patients had metastatic deposits in lymph nodes,lung,or bone and majority of these were anaplastic.Twenty patients received surgical treatment.Five total thyroidectomy, 12 had subtotal thyroidectomy,3 had hemithyroidectomy and 2 had radioactive iodine treatment without surgery.
Most patients received subtotal thyroidectomy with or without radiotherapy. The anaplastic cancers had the poorest prognosis, all dying within six months of diagnosis.Early diagnosis with frozen section the papillary/follicular possess good prognosis if appropriate surgical treatment of subtotal or hemithyroidectomy is done.

S PROFKIGONDUCHRISTINE. "Ndavi Muia P., Mwalali P.N., Mbugua S.E., Sekadde-Kigondu C.B., Mati J. K. G.Cervical cytology in a Kenyan rural population. J. Obstet. Gynaecol. E. and Central Afr. 3:167, 1984.". In: J. Obstet. Gynaecol. E. and Central Afr. 3:167, 1984. uon press; 1984. Abstract

PIP: 125 black Kenyan women attending the Kenyatta National Family Welfare Clinic were randomly allocated to combined and fixed dose oral contraceptives (Eugynon: 500 mcg dl-norgestrel + 50 mcg ethinyl estradiol or Microgynon: 150 mcg levonorgestel + 30 mcg ethinyl estradiol). They were between 18-33 years of age with a mean of 25 +or- 7 years. The mean parity of this group was 3 and they had a mean education standard of 8 years. Fasting blood sampled were taken on recruitment (control cycle) and thereafter once for cycles 1, 3, 6, 9, and 12 during OC use. HDL-cholesterol was estimated in the sear. The 2 OCs elicited a significant decrease in levels of HDL-cholesterol (p0.01). author's modified

S PROFKIGONDUCHRISTINE. "Obwaka JM, Mati JK, Lequin RM, Sekadde-kigondu CB, Muitta MN, Nthale JM, Njoroge JK. Baseline studies on semen and hormonal parameters in fertile Black males in Kenya. J Obstet Gynaecol East Cent Africa. 1982 Jun;1(2):96-9.". In: J. Obs/Gyn. East Central Africa 1:126(1982). uon press; 1982. Abstract

PIP: Masturbatory semen specimen from 49 fertile Black African males in Kenya whose wives were pregnant was obtained after at least 3 days of abstinence for the analysis of parameters which included volume motility, vitality, sperm concentration, pH, fructose and acid phosphatase levels. About 1/2 the spermatozoa was actively progressive in motility, while 40% was nonmotile. Vitality in the 1st hour revealed that 81.4% of the sperm was alive. About 90% of the semen specimens had more than 40% idea forms of spermatozoa. Spermatozoal abnormalities were a frequent feature. There was no correlation between age and the testicular volume, but seminal fluid volume and sperm density tended to decrease with age. Serum levels of Follicle Stimulating Hormone, Luteinizing Hormone, Prolactin and Testosterone were determined in the subjects' sera, enabling the establishment of reference values for these parameters in African Kenyan males.

S PROFIGONSANGWASHIBAIRO. "Changes in water potential, osmotic potential, and tissue electrolyte leakage during mass loss in carrots stored under different conditions. Scientia Horticulturae, 95: 13-21.". In: African Crop Science Proceedings 6: 536-540. Taylor & Francis; 2002. Abstract
Normal 0 false false false MicrosoftInternetExplorer4 st1:*{behavior:url(#ieooui) } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} Hepatocellular carcinoma results when cancerous cells are localized in the liver. It is distributed globally with high prevalence in sub-Saharan African, southern Asia, China and Japan. Diagnosis is experimental and in many cases inaccurate due to unreliability of markers. Prognosis is poor and the cost of treatment prohibitive. Conventional radiation and chemotherapy lead to loss of hair, fertility and general weakening of the body`s immune system increasing a patient`s risk to infection. These observations underscore the need for improved, or additional methods of cancer diagnosis and management. We investigated the effect of polysaccharide rich Pleurotus pulmonarius fruit body extracts on progression of chemically induced hepatocellular carcinoma in CBA mice. Addition of Pleurotus pulmonarius extracts in diet delayed progression of carcinogenesis suggesting   that these extracts may be useful as   adjuvants to conventional cancer therapies.   Key words: carcinogenesis; mice; mushroom extracts; pleurotus pulmunarius   Corresponding author: Ms Carolyne Wasonga, Department of Biochemistry, University of Nairobi, P.O. Box 30197, Nairobi,  Kenya. E-mail: carox27@yahoo.ca     Charles O.A. Omwandho, Susanne E. Gruessner, John Falconer, Hans-R Tinneberg, Timothy K. Roberts. IS OVINE PLACENTAL IGG TOXIC TO HUMAN PERIPHERAL BLOOD NATURAL KILLER CELLS?
S PROFKIGONDUCHRISTINE. "Ochiel DO, Wango EO, Kigondu CS, Otsyula MG. Effect of menstrual cycle on mucosal immunity to SHIV within the reproductive tract of baboons (Papio anubis): preliminary findings.J Med Primatol. 2003 Jun;32(3):161-9.". In: J Med Primatol. 2003 Jun;32(3):161-9. uon press; 2003. Abstract
Reproductive Biology Unit, Department of Animal Physiology, University of Nairobi, Kenya. dochiel@kisian.mimcom.net The presence of human immunodeficiency virus (HIV) in genital secretions is regarded as a risk factor for sexual and perinatal transmission of HIV. A better understanding of correlates of genital shedding of HIV is crucial to the development of effective strategies against transmission of this virus. Events during menstrual cycle are likely to influence local immune responses and viral load in genital secretions, and hence determine susceptibility to HIV or efficiency of virus transmission. We report, in this study, preliminary findings on the relationship of menstrual cycle to genital mucosal and systemic immunity in female olive baboons (Papio anubis) experimentally inoculated with simian/human immunodeficiency virus (SHIV)89.6P.
S PROFKIGONDUCHRISTINE. "Noreh, J.,Sekadde-Kigondu, C.B., Karanja, J.G., Thagana, N.G. Median Age at Menopause in a Rural. Population of Western Kenya. E.A.Med. J. 74; 634, 1997.". In: E.A.Med. J. 74; 634, 1997. uon press; 1997. Abstract
Aga Khan Hospital, Nairobi. Forty females, age 14 to 35 years (mean 28.6 years) with chronic renal failure (CRF) were included in the study. Their menstrual patterns were noted. The function of their hypothalamo-pituitary-ovarian axis was assessed by the serum levels of follicle stimulating hormone (FSH), Luteinising hormone (LH), prolactin (PrL), estradiol (E2) and progesterone (P) at different phases of the menstrual cycle in patients who continued to have normal menses (Group 1) and at weekly intervals for six weeks in patients with menstrual disturbances (Group II). The mean hormone levels during the initial contact Luteal phase in group I were FSH 12.0 IU/L (N, 1.0-3.0 IU/L), LH 1.8IU/L (N 1.5-101U/L), PrL 652mIU/L (N, 100-600 mIU/L) mE2 160 pmol/L (N 400-1400 pmol/L) and P5 nmol/L (N 14-60 nmol/L) for group I. Corresponding values for group II were 1.2, 10.3, 250, 600 and 3.0 in relevant units. All patients (fourteen) with end stage renal disease (ESRD) had amenorrhoae. On the other hand, most patients with stable CRF (22/26) had normal menses. Following initiation of therapy (conservative or dialytic), there was no significant alteration in the hormonal profile or menstrual pattern. We conclude that other factors apart from the hormonal imbalances, may be responsible for the menstrual disturbances noted in patients with CRF.
S PROFMASINDEMICHAEL. "Mnjalla, N., Masinde M. S. Trachoma survey in primary schools in Machakos District, Kenya E. African of Ophthalmology 5: 25 .". In: Kenya E. African of Ophthalmology 5: 25 .; 1982. Abstract
OBJECTIVE: To determine the prevalence of Xerophthalmia among Kenyan children aged four to seven years in high risk using Conjuctival Impression Cytology and transfer. DESIGN: A cross sectional community based study. SETTING: Mathare slum in Nairobi and Tiva/Ithiani area of Kitui. SUBJECTS: Children aged four to seven years residing in the above areas were assessed for both clinical and cytological features of vitamin A deficiency. RESULTS: Of the 342 children included in this study, 316 (92.0%) were normal, five (1.5%) had XN, 19 (5.9% had XIA and two (0.6%) had XIB. No signs of corneal Xerophthalmia were seen in this study. Conjuctival impression cytology and transfer (CICT) was used to asses for squamous metaplastic changes associated with Vitamin A deficiency (VAD). Seventy five (23.1%) of the children were normal by CICT while 249 (76.9%) were abnormal. In comparing the two areas of study, only 13.2% of the children in Mathare had normal CICT compared to 50% in Kitui. For each of the age groups studied there was significant difference between the two areas with children from Mathare being more deficient than those from Kitui. CONCLUSION: VAD is a significant health problem in the high risk areas assessed by CICT in this study.
S DRKARANJAHDOMINIC. "Karanja D.S .". In: The Limnology, Climatology and Palaeoclimatology of the East African Lakes pp. 413-431, Gordon and Breach Publishers, Amsterdam. June 1996 b) Books Reference Date. Earthscan, London. 978-1-84407-469-3 (*); 1984. Abstract
n/a
S PROFKIGONDUCHRISTINE. "J.J. Bwayo, A.N. Mutere, M.A. Omari, J.K. Kreiss. W. Jaoko, C. Sekadde-Kigondu, F.A. Plummer. Long distance truck driver: Knowledge and attitudes concerning sexually transmitted diseases and sexual behaviour E.A. Med. J. 68 (90), 714, 1991.". In: E.A. Med. J. 68 (90), 714, 1991. uon press; 1991. Abstract
Forty females, age 14 to 35 years (mean 28.6 years) with chronic renal failure (CRF) were included in the study. Their menstrual patterns were noted. The function of their hypothalamo-pituitary-ovarian axis was assessed by the serum levels of follicle stimulating hormone (FSH), Luteinising hormone (LH), prolactin (PrL), estradiol (E2) and progesterone (P) at different phases of the menstrual cycle in patients who continued to have normal menses (Group 1) and at weekly intervals for six weeks in patients with menstrual disturbances (Group II). The mean hormone levels during the initial contact Luteal phase in group I were FSH 12.0 IU/L (N, 1.0-3.0 IU/L), LH 1.8IU/L (N 1.5-101U/L), PrL 652mIU/L (N, 100-600 mIU/L) mE2 160 pmol/L (N 400-1400 pmol/L) and P5 nmol/L (N 14-60 nmol/L) for group I. Corresponding values for group II were 1.2, 10.3, 250, 600 and 3.0 in relevant units. All patients (fourteen) with end stage renal disease (ESRD) had amenorrhoae. On the other hand, most patients with stable CRF (22/26) had normal menses. Following initiation of therapy (conservative or dialytic), there was no significant alteration in the hormonal profile or menstrual pattern. We conclude that other factors apart from the hormonal imbalances, may be responsible for the menstrual disturbances noted in patients with CRF.
S G, M. NL, Motuka JM, M. MK. "Analysis of Gender Equity in Secondary Schools in Mandera East District, Mandera County, Kenya." International Journal of Innovative Research & Studies . 2014;3(3):480-492.
S PROFOLIECHJOSEPH. "Thyroid enlargement and the trachea ASEA proceedings, 1980.". In: ASEA proceedings, 1980. PROF.J.S.OLIECH; 1980. Abstract

ABSTRACT.
Although it has been said that local symptoms are uncommon and that large goiters are oftenwell tolerated ( Sloan,1971), this is not true of our patients.Pressure effects may depend upon size and position of the the gland but asymmetry of nodular thyroid and strong anterior neck muscles and fasciamay cause severe compression or deviation of the trachea. In KNH,Nairobi, we have been truck by the frequency of the pressure symptoms caused by these goiter weighing less than 100gms
t

S PROFKIGONDUCHRISTINE. "Eshitera M.O., Sekadde-Kigondu C.B., Mati J.K.G.,Muitta M.N., Njoroge J.K. J. Obstet. Gynaecol. E. Central Afr. 3:141, 1984 Semen parameters, hormonal studies and incidence of asymptomatic bacteriospermia in fertile black males in Kenya.". In: J. Obstet. Gynaecol. E. and Central Afr. 4:45, 1985. uon press; 1984. Abstract

PIP: 125 black Kenyan women attending the Kenyatta National Family Welfare Clinic were randomly allocated to combined and fixed dose oral contraceptives (Eugynon: 500 mcg dl-norgestrel + 50 mcg ethinyl estradiol or Microgynon: 150 mcg levonorgestel + 30 mcg ethinyl estradiol). They were between 18-33 years of age with a mean of 25 +or- 7 years. The mean parity of this group was 3 and they had a mean education standard of 8 years. Fasting blood sampled were taken on recruitment (control cycle) and thereafter once for cycles 1, 3, 6, 9, and 12 during OC use. HDL-cholesterol was estimated in the sear. The 2 OCs elicited a significant decrease in levels of HDL-cholesterol (p0.01). author's modified

S PROFKIGONDUCHRISTINE. "Mukasa F., Mati J.K.G., Sekadde-Kigondu C.B., Lequin R.M. J. Obstet. Gynaecol. E. Central Afr. 1:160, 1982 Pituitary reserve for gonadotrophin and prolactin in women using long term depo-provera.". In: J. Obstet. Gynaecol. E. Central Afr. 1:160, 1982. uon press; 1982. Abstract
PIP: Menstrual blood loss (MBL) was evaluated in 74 nulliporous Kenyan women aged between 20 and 27 years. The hemoglobin levels were all in normal range with the mean of 13.65 +or- 0.8, 13.84 +or- 1.2 and 13.04 +or- 1.2 g/100 ml respectively in 3 populations. The MBL was comparable in the 3 populations with the mean of 35.1 +or- 12.6, 30.6 +or- 8.7 and 32.2 +or- 9.4 ml respectively. There was no difference of statistical significance between the 2 periods studied per each individual. This study objectively assesses the menstrual blood loss in 3 population groups–2 urban and 1 rural. The data can be used to evaluate menstrual blood loss before and after initiation of various contraceptives used in Kenya. Subjects were volunteers who were not on any contraception except barrier or natural rhythm methods, not under psychological stress and who exhibited normal physical female characteristics on examination. Those who wished to drop out, became pregnant or desired contraception, were excluded. The study confirms the individual constancy of the menstrual blood loss in this population. This has important practical implications since a single determination of the menstrual blood loss may be a fairly good expression for the average blood loss in a woman. The immediate effect of various treatments such as IUD insertion or oral contraceptives on the MBL may easily be evaluated quantitatively by measurements in consecutive periods using only 1 period as a control. The quick method can be easily used in evaluating pathological conditions e.g. iron-deficiency due to heavy bleeding, IUD-associated hemorrhage, menorrhagia and uterine fibroid. PMID: 12267056 [PubMed - indexed for MEDLINE]
S PROFIGONSANGWASHIBAIRO. "Effects of nitrogen and phosphorus on growth and yield of ironweed (Vernonia galamesis). East African Agriculture and Forestry Journal, 60 (2): 109- 118.". In: Proceedings. 6th triennial congress of the African Potato Association (APA). 5-10 April, 2004. Agadir, Morocco. Pp.298-299. Taylor & Francis; 2003. Abstract
Normal 0 false false false MicrosoftInternetExplorer4 st1:*{behavior:url(#ieooui) } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} Hepatocellular carcinoma results when cancerous cells are localized in the liver. It is distributed globally with high prevalence in sub-Saharan African, southern Asia, China and Japan. Diagnosis is experimental and in many cases inaccurate due to unreliability of markers. Prognosis is poor and the cost of treatment prohibitive. Conventional radiation and chemotherapy lead to loss of hair, fertility and general weakening of the body`s immune system increasing a patient`s risk to infection. These observations underscore the need for improved, or additional methods of cancer diagnosis and management. We investigated the effect of polysaccharide rich Pleurotus pulmonarius fruit body extracts on progression of chemically induced hepatocellular carcinoma in CBA mice. Addition of Pleurotus pulmonarius extracts in diet delayed progression of carcinogenesis suggesting   that these extracts may be useful as   adjuvants to conventional cancer therapies.   Key words: carcinogenesis; mice; mushroom extracts; pleurotus pulmunarius   Corresponding author: Ms Carolyne Wasonga, Department of Biochemistry, University of Nairobi, P.O. Box 30197, Nairobi,  Kenya. E-mail: carox27@yahoo.ca     Charles O.A. Omwandho, Susanne E. Gruessner, John Falconer, Hans-R Tinneberg, Timothy K. Roberts. IS OVINE PLACENTAL IGG TOXIC TO HUMAN PERIPHERAL BLOOD NATURAL KILLER CELLS?
S PROFKIGONDUCHRISTINE. "C.O.Onuango, FW Maina C Sekadde-Kigondu and JKG Mati Effect of DMPA on Lipid and Lipoprotein Changes in the First three months and long term use. J.Obstet Gynaecol E.C. Afr. 16(10 54, 2003.". In: J.Obstet Gynaecol E.C. Afr. 16(10 54, 2003. uon press; 2003. Abstract
The presence of human immunodeficiency virus (HIV) in genital secretions is regarded as a risk factor for sexual and perinatal transmission of HIV. A better understanding of correlates of genital shedding of HIV is crucial to the development of effective strategies against transmission of this virus. Events during menstrual cycle are likely to influence local immune responses and viral load in genital secretions, and hence determine susceptibility to HIV or efficiency of virus transmission. We report, in this study, preliminary findings on the relationship of menstrual cycle to genital mucosal and systemic immunity in female olive baboons (Papio anubis) experimentally inoculated with simian/human immunodeficiency virus (SHIV)89.6P.
S PROFKIGONDUCHRISTINE. "Mutungi, A.K., Sanghvi, H.C.G., Sinei, S.K., Ojwang, S.B.O., Sekadde-Kigondu,C.B. Contraceptive Acceptance and Continuation Among Women Managed for Incomplete Abortion at Kenyatta National Hospital.J. Obstet. Gynaecol. E. Centr. Afr. 14; 78. 1998.". In: J. Obstet. Gynaecol. E. Centr. Afr. 14; 78. 1998. uon press; 1998. Abstract
Aga Khan Hospital, Nairobi. Forty females, age 14 to 35 years (mean 28.6 years) with chronic renal failure (CRF) were included in the study. Their menstrual patterns were noted. The function of their hypothalamo-pituitary-ovarian axis was assessed by the serum levels of follicle stimulating hormone (FSH), Luteinising hormone (LH), prolactin (PrL), estradiol (E2) and progesterone (P) at different phases of the menstrual cycle in patients who continued to have normal menses (Group 1) and at weekly intervals for six weeks in patients with menstrual disturbances (Group II). The mean hormone levels during the initial contact Luteal phase in group I were FSH 12.0 IU/L (N, 1.0-3.0 IU/L), LH 1.8IU/L (N 1.5-101U/L), PrL 652mIU/L (N, 100-600 mIU/L) mE2 160 pmol/L (N 400-1400 pmol/L) and P5 nmol/L (N 14-60 nmol/L) for group I. Corresponding values for group II were 1.2, 10.3, 250, 600 and 3.0 in relevant units. All patients (fourteen) with end stage renal disease (ESRD) had amenorrhoae. On the other hand, most patients with stable CRF (22/26) had normal menses. Following initiation of therapy (conservative or dialytic), there was no significant alteration in the hormonal profile or menstrual pattern. We conclude that other factors apart from the hormonal imbalances, may be responsible for the menstrual disturbances noted in patients with CRF.
S PROFMASINDEMICHAEL. "Masinde, M. S., Adala, H. S., Kabuleeta, H. Corneal Ulcers at Kenyatta National Hospital. E. African Journal of Ophthalmology 8: 65.". In: E. African Journal of Ophthalmology 8: 65.; 1988. Abstract
OBJECTIVE: To determine the prevalence of Xerophthalmia among Kenyan children aged four to seven years in high risk using Conjuctival Impression Cytology and transfer. DESIGN: A cross sectional community based study. SETTING: Mathare slum in Nairobi and Tiva/Ithiani area of Kitui. SUBJECTS: Children aged four to seven years residing in the above areas were assessed for both clinical and cytological features of vitamin A deficiency. RESULTS: Of the 342 children included in this study, 316 (92.0%) were normal, five (1.5%) had XN, 19 (5.9% had XIA and two (0.6%) had XIB. No signs of corneal Xerophthalmia were seen in this study. Conjuctival impression cytology and transfer (CICT) was used to asses for squamous metaplastic changes associated with Vitamin A deficiency (VAD). Seventy five (23.1%) of the children were normal by CICT while 249 (76.9%) were abnormal. In comparing the two areas of study, only 13.2% of the children in Mathare had normal CICT compared to 50% in Kitui. For each of the age groups studied there was significant difference between the two areas with children from Mathare being more deficient than those from Kitui. CONCLUSION: VAD is a significant health problem in the high risk areas assessed by CICT in this study.
S PROFKIGONDUCHRISTINE. "Rukaria,RM, Ojwang SBO, Oyieke, KB and Sekadde-Kigondu CB In Vitro and In Vivo response to plasmodium Falciparum to chloroquine in pregnant women in Kilifi in Kenya. E.Afr. Med J. 69 306-308, 1992.". In: E.Afr. Med J. 69 306-308, 1992. uon press; 1992. Abstract
Forty females, age 14 to 35 years (mean 28.6 years) with chronic renal failure (CRF) were included in the study. Their menstrual patterns were noted. The function of their hypothalamo-pituitary-ovarian axis was assessed by the serum levels of follicle stimulating hormone (FSH), Luteinising hormone (LH), prolactin (PrL), estradiol (E2) and progesterone (P) at different phases of the menstrual cycle in patients who continued to have normal menses (Group 1) and at weekly intervals for six weeks in patients with menstrual disturbances (Group II). The mean hormone levels during the initial contact Luteal phase in group I were FSH 12.0 IU/L (N, 1.0-3.0 IU/L), LH 1.8IU/L (N 1.5-101U/L), PrL 652mIU/L (N, 100-600 mIU/L) mE2 160 pmol/L (N 400-1400 pmol/L) and P5 nmol/L (N 14-60 nmol/L) for group I. Corresponding values for group II were 1.2, 10.3, 250, 600 and 3.0 in relevant units. All patients (fourteen) with end stage renal disease (ESRD) had amenorrhoae. On the other hand, most patients with stable CRF (22/26) had normal menses. Following initiation of therapy (conservative or dialytic), there was no significant alteration in the hormonal profile or menstrual pattern. We conclude that other factors apart from the hormonal imbalances, may be responsible for the menstrual disturbances noted in patients with CRF.
S PROFOLIECHJOSEPH. "Male infertility at KNH. Medicom Vol. 2:95, 1980.". In: Medicom Vol. 2:95, 1980. PROF.J.S.OLIECH; 1980. Abstract

No a ABSTRACT.
Ten males,6 of whom were azoospermic and 4 oligospermic were studied for their subfertilityor infertility after the gynaecologist had proven wives normal and referred them to urology clinic for further tests .Study showed that the causes of subfertility or infertility are uncorrectable and in the few that can be corrected, the results of the improved fertility in so far as getting child is concerned has no workable formula.
bstract yet

S PROFKIGONDUCHRISTINE. "Kibunguchy W., Mbugua S.E., Sekadde-Kigondu C.B., Mati J.K.G. Carcinoma of the cervix and cervical intra-epithelial neoplasia (CIN). Screening a high risk group. J. Obstet Gynaecol. E. and Central Afr. 4:29, 1985.". In: J. Obstet Gynaecol. E. and Central Afr. 4:29, 1985. uon press; 1985. Abstract

PIP: 125 black Kenyan women attending the Kenyatta National Family Welfare Clinic were randomly allocated to combined and fixed dose oral contraceptives (Eugynon: 500 mcg dl-norgestrel + 50 mcg ethinyl estradiol or Microgynon: 150 mcg levonorgestel + 30 mcg ethinyl estradiol). They were between 18-33 years of age with a mean of 25 +or- 7 years. The mean parity of this group was 3 and they had a mean education standard of 8 years. Fasting blood sampled were taken on recruitment (control cycle) and thereafter once for cycles 1, 3, 6, 9, and 12 during OC use. HDL-cholesterol was estimated in the sear. The 2 OCs elicited a significant decrease in levels of HDL-cholesterol (p0.01). author's modified

S PROFKIGONDUCHRISTINE. "Ndeto G.W., Mati J.K.G., Sekadde-Kigondu C.B., et al J. Obstet. Gynaecol. E. Central Afr. 1:58, 1982 Prolactin release in subjects with uterine fibroid.". In: J. Obstet. Gynaecol. E. Central Afr. 1:58, 1982. uon press; 1982. Abstract
PIP: Menstrual blood loss (MBL) was evaluated in 74 nulliporous Kenyan women aged between 20 and 27 years. The hemoglobin levels were all in normal range with the mean of 13.65 +or- 0.8, 13.84 +or- 1.2 and 13.04 +or- 1.2 g/100 ml respectively in 3 populations. The MBL was comparable in the 3 populations with the mean of 35.1 +or- 12.6, 30.6 +or- 8.7 and 32.2 +or- 9.4 ml respectively. There was no difference of statistical significance between the 2 periods studied per each individual. This study objectively assesses the menstrual blood loss in 3 population groups–2 urban and 1 rural. The data can be used to evaluate menstrual blood loss before and after initiation of various contraceptives used in Kenya. Subjects were volunteers who were not on any contraception except barrier or natural rhythm methods, not under psychological stress and who exhibited normal physical female characteristics on examination. Those who wished to drop out, became pregnant or desired contraception, were excluded. The study confirms the individual constancy of the menstrual blood loss in this population. This has important practical implications since a single determination of the menstrual blood loss may be a fairly good expression for the average blood loss in a woman. The immediate effect of various treatments such as IUD insertion or oral contraceptives on the MBL may easily be evaluated quantitatively by measurements in consecutive periods using only 1 period as a control. The quick method can be easily used in evaluating pathological conditions e.g. iron-deficiency due to heavy bleeding, IUD-associated hemorrhage, menorrhagia and uterine fibroid. PMID: 12267056 [PubMed - indexed for MEDLINE]
S PROFIGONSANGWASHIBAIRO. "Seed source and farmer management practices and their effect on aphid and virus incidence in farmer managed seed potato production in Kenya.". In: Proceedings. 6th triennial congress of the African Potato Association (APA). 5-10 April, 2004. Agadir, Morocco. Pp.298-299. Taylor & Francis; 2004. Abstract
Normal 0 false false false MicrosoftInternetExplorer4 st1:*{behavior:url(#ieooui) } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} Hepatocellular carcinoma results when cancerous cells are localized in the liver. It is distributed globally with high prevalence in sub-Saharan African, southern Asia, China and Japan. Diagnosis is experimental and in many cases inaccurate due to unreliability of markers. Prognosis is poor and the cost of treatment prohibitive. Conventional radiation and chemotherapy lead to loss of hair, fertility and general weakening of the body`s immune system increasing a patient`s risk to infection. These observations underscore the need for improved, or additional methods of cancer diagnosis and management. We investigated the effect of polysaccharide rich Pleurotus pulmonarius fruit body extracts on progression of chemically induced hepatocellular carcinoma in CBA mice. Addition of Pleurotus pulmonarius extracts in diet delayed progression of carcinogenesis suggesting   that these extracts may be useful as   adjuvants to conventional cancer therapies.   Key words: carcinogenesis; mice; mushroom extracts; pleurotus pulmunarius   Corresponding author: Ms Carolyne Wasonga, Department of Biochemistry, University of Nairobi, P.O. Box 30197, Nairobi,  Kenya. E-mail: carox27@yahoo.ca     Charles O.A. Omwandho, Susanne E. Gruessner, John Falconer, Hans-R Tinneberg, Timothy K. Roberts. IS OVINE PLACENTAL IGG TOXIC TO HUMAN PERIPHERAL BLOOD NATURAL KILLER CELLS?
S PROFKIGONDUCHRISTINE. "Rajab JA, Muchina WP, Orinda DA, Scott CS. Blood donor haematology parameters in two regions of Kenya. East Afr Med J. 2005 Mar;82(3):123-7.". In: East Afr Med J. 2005 Nov;82(11):565-71. uon press; 2005. Abstract
OBJECTIVES: To determine the status of blood donor haematology in two regional sites in Kenya and to assess the potential role of automated haematology in National blood bank process control. DESIGN: A cross sectional descriptive study. SETTING: Two regional blood banks–Nairobi and its environs (Blood Transfusion Services, Nairobi) and Western Region (National Blood Transfusion Services, Kisumu). MAIN OUTCOME MEASURES: Distribution, mean, median, and 95% percentile ranges of haemoglobin (Hb), red cell parameters (red cell count, haematocrit, MCV, MCH and MCHC), total and differential white blood cell (WBC) counts, and platelet counts in the two donor populations. RESULTS: A significant number of donations (16.5% in Kisumu and 3.4% in Nairobi) showed haemoglobin levels below the recommended National Blood Transfusion Service (NBTS) guideline of 42g/unit. Compared to Kisumu, Nairobi donors had significantly (p < 0.001) higher Hb, MCV and MCH values while the red blood cell counts and MCHC values were similar (p > 0.05). A low MCV (< 78 fl) was observed in 12.4% and 3.4% of Kisumu and Nairobi donors respectively. Both populations showed similar but significant frequencies (Kisumu, 21.3%; Nairobi, 18.7%) of mild neutropenia (< 1.5 x 10(9)/1), while eosinophilia (> 0.5 x 10(9)/1 in the tropics the cut off is > 0.6 x 109) was more prominent in Kisumu donors (18.8% versus 8.5%). Platelet counts were also significantly lower in Kisumu donors, with the prevalence of thrombocytopenia (< 150 x 10(9)/1) being considerably higher (15.9% versus 3.7%). CONCLUSIONS: A significant number of Kenyan donors showed abnormal haematology profiles that may indicate underlying pathology. Such abnormalities are not detected by current blood transfusion services screening practices and there may be a need to strengthen donor selection criteria to protect both donors and recipients.
S PROFKIGONDUCHRISTINE. "Kirumbi, L.W., Makokha, E.A., Mukolwe, B.A., Sekadde-Kigondu, C.B., Nichols, D. Causes fo Maternal Mortality in Three Districts In Kenya: Kilifi, Kirinyaga and Kakamega. J. Obstet. Gynaecol. E. and Centr. Afr. 14:62, 1998.". In: J. Obstet. Gynaecol. E. and Centr. Afr. 14:62. uon press; 1998. Abstract
Aga Khan Hospital, Nairobi. Forty females, age 14 to 35 years (mean 28.6 years) with chronic renal failure (CRF) were included in the study. Their menstrual patterns were noted. The function of their hypothalamo-pituitary-ovarian axis was assessed by the serum levels of follicle stimulating hormone (FSH), Luteinising hormone (LH), prolactin (PrL), estradiol (E2) and progesterone (P) at different phases of the menstrual cycle in patients who continued to have normal menses (Group 1) and at weekly intervals for six weeks in patients with menstrual disturbances (Group II). The mean hormone levels during the initial contact Luteal phase in group I were FSH 12.0 IU/L (N, 1.0-3.0 IU/L), LH 1.8IU/L (N 1.5-101U/L), PrL 652mIU/L (N, 100-600 mIU/L) mE2 160 pmol/L (N 400-1400 pmol/L) and P5 nmol/L (N 14-60 nmol/L) for group I. Corresponding values for group II were 1.2, 10.3, 250, 600 and 3.0 in relevant units. All patients (fourteen) with end stage renal disease (ESRD) had amenorrhoae. On the other hand, most patients with stable CRF (22/26) had normal menses. Following initiation of therapy (conservative or dialytic), there was no significant alteration in the hormonal profile or menstrual pattern. We conclude that other factors apart from the hormonal imbalances, may be responsible for the menstrual disturbances noted in patients with CRF.
S PROFMASINDEMICHAEL, R. DRILAKODUNERA. "D.R. Ilako, M. Bhaiji, M.S. Masinde Immunoglobulin Levels in Tears M.Med Thesis 1991.". In: M.Med Thesis 1991.; 1991. Abstract
OBJECTIVE: To determine the prevalence of Xerophthalmia among Kenyan children aged four to seven years in high risk using Conjuctival Impression Cytology and transfer. DESIGN: A cross sectional community based study. SETTING: Mathare slum in Nairobi and Tiva/Ithiani area of Kitui. SUBJECTS: Children aged four to seven years residing in the above areas were assessed for both clinical and cytological features of vitamin A deficiency. RESULTS: Of the 342 children included in this study, 316 (92.0%) were normal, five (1.5%) had XN, 19 (5.9% had XIA and two (0.6%) had XIB. No signs of corneal Xerophthalmia were seen in this study. Conjuctival impression cytology and transfer (CICT) was used to asses for squamous metaplastic changes associated with Vitamin A deficiency (VAD). Seventy five (23.1%) of the children were normal by CICT while 249 (76.9%) were abnormal. In comparing the two areas of study, only 13.2% of the children in Mathare had normal CICT compared to 50% in Kitui. For each of the age groups studied there was significant difference between the two areas with children from Mathare being more deficient than those from Kitui. CONCLUSION: VAD is a significant health problem in the high risk areas assessed by CICT in this study.
S PROFKIGONDUCHRISTINE. "Menstrual disorders in patients with chronic renal failure. East Afr Med J. 1993 Jan;70(1):6-9. PMID: 8513732 [PubMed - indexed for MEDLINE].". In: J. Obstet. Gynaecol E.and Centr. Afric 11: 3, 1993. uon press; 1993. Abstract
Forty females, age 14 to 35 years (mean 28.6 years) with chronic renal failure (CRF) were included in the study. Their menstrual patterns were noted. The function of their hypothalamo-pituitary-ovarian axis was assessed by the serum levels of follicle stimulating hormone (FSH), Luteinising hormone (LH), prolactin (PrL), estradiol (E2) and progesterone (P) at different phases of the menstrual cycle in patients who continued to have normal menses (Group 1) and at weekly intervals for six weeks in patients with menstrual disturbances (Group II). The mean hormone levels during the initial contact Luteal phase in group I were FSH 12.0 IU/L (N, 1.0-3.0 IU/L), LH 1.8IU/L (N 1.5-101U/L), PrL 652mIU/L (N, 100-600 mIU/L) mE2 160 pmol/L (N 400-1400 pmol/L) and P5 nmol/L (N 14-60 nmol/L) for group I. Corresponding values for group II were 1.2, 10.3, 250, 600 and 3.0 in relevant units. All patients (fourteen) with end stage renal disease (ESRD) had amenorrhoae. On the other hand, most patients with stable CRF (22/26) had normal menses. Following initiation of therapy (conservative or dialytic), there was no significant alteration in the hormonal profile or menstrual pattern. We conclude that other factors apart from the hormonal imbalances, may be responsible for the menstrual disturbances noted in patients with CRF.
S PROFOLIECHJOSEPH. "Indwelling catheter and catheter induced Infections Assoc. of Surgeons of E.A. proceedings Dec. 1982.". In: Assoc. of Surgeons of E.A. proceedings Dec. 1982. PROF.J.S.OLIECH; 1982. Abstract

NoSUMMARY.

A study of patients at St Peter’s Group of Hospitals,(Central London), University of London,and at Kenyatta National Hospital,University of Nairobi who had indwelling catheters for various reasons was done to compare the rates of catheter-induced infections in relation to the type/make,size fenestration or not and duration of stay in situ.
The closed system in the indwelling of catheters was the most important factor in reducing the infection rate to lessthan 10%. Breaking it increases the infection to 90%.
abstract yet

S PROFKIGONDUCHRISTINE. "Maina F.W., Sekadde-Kigondu C.B, Ojwang P.J. Mati J.K.G. Changes of plasma HDL-Cholesterol in women using oral contraceptives. E. Afr. Med. J., 64 (7) 442, 1987.". In: E. Afr. Med. J., 64 (7) 442, 1987. uon press; 1987. Abstract
Kenya Medical Research Institute, Clinical Research Centre, Nairobi. Twenty nine patients with rickets were studied in a one year period. The majority of patients (17/29) were below 2 years of age. Most of them had nutritional rickets resulting from a combination of factors. Premature delivery, nonexposure to sunlight, nutritional marasmus and inappropriate dietary intake. Some had familial hypophosphataemic rickets, others had renal tubular acidosis while the rest had rickets with a familial tendency. Both the previous hospital records and the present study indicate that rickets is a persistent problem in children in the community and should be suspected in children who present with features of failure to thrive, among other conditions.
S PROFKIGONDUCHRISTINE. "Mwalali P.N., Mati J.K.G., Sekadde-Kigondu C.B., Lequin R.M., J. Obstet. Gynaecol. E. Central Africa,1:64, 1982 The Effects of GnRH and TRH on pituitary secretion of FSH, LH and PRL in Normal Kenyan Males.". In: J. Obstet. Gynaecol. E. Central Africa,1:64, 1982. uon press; 1982. Abstract
PIP: Menstrual blood loss (MBL) was evaluated in 74 nulliporous Kenyan women aged between 20 and 27 years. The hemoglobin levels were all in normal range with the mean of 13.65 +or- 0.8, 13.84 +or- 1.2 and 13.04 +or- 1.2 g/100 ml respectively in 3 populations. The MBL was comparable in the 3 populations with the mean of 35.1 +or- 12.6, 30.6 +or- 8.7 and 32.2 +or- 9.4 ml respectively. There was no difference of statistical significance between the 2 periods studied per each individual. This study objectively assesses the menstrual blood loss in 3 population groups–2 urban and 1 rural. The data can be used to evaluate menstrual blood loss before and after initiation of various contraceptives used in Kenya. Subjects were volunteers who were not on any contraception except barrier or natural rhythm methods, not under psychological stress and who exhibited normal physical female characteristics on examination. Those who wished to drop out, became pregnant or desired contraception, were excluded. The study confirms the individual constancy of the menstrual blood loss in this population. This has important practical implications since a single determination of the menstrual blood loss may be a fairly good expression for the average blood loss in a woman. The immediate effect of various treatments such as IUD insertion or oral contraceptives on the MBL may easily be evaluated quantitatively by measurements in consecutive periods using only 1 period as a control. The quick method can be easily used in evaluating pathological conditions e.g. iron-deficiency due to heavy bleeding, IUD-associated hemorrhage, menorrhagia and uterine fibroid. PMID: 12267056 [PubMed - indexed for MEDLINE]
S PROFKIGONDUCHRISTINE, W MRMAINAFRANCIS. "Ojwang PJ, Ogada T, Maina FW, Sekadde-Kigondu CB, Mati JK. Reference values for serum lipids and lipoprotein cholesterol in adults and cord blood of Kenyan Africans. East Afr Med J. 1984 May;61(5):367-71.". In: E. Africa. Med. J. 61, 637 ( 1984). EM Ngatia, LW Gathece, FG Macigo, TK Mulli, LN Mutara, EG Wagaiyu.; 1984. Abstract
No abstract available.
S PROFIGONSANGWASHIBAIRO. "Comparative resistance/tolerance of commercial potato cultivars in Kenya to major aphid pests.". In: In press. African Crop Science Proceedings 7: -. Taylor & Francis; 2005. Abstract
Normal 0 false false false MicrosoftInternetExplorer4 st1:*{behavior:url(#ieooui) } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} Hepatocellular carcinoma results when cancerous cells are localized in the liver. It is distributed globally with high prevalence in sub-Saharan African, southern Asia, China and Japan. Diagnosis is experimental and in many cases inaccurate due to unreliability of markers. Prognosis is poor and the cost of treatment prohibitive. Conventional radiation and chemotherapy lead to loss of hair, fertility and general weakening of the body`s immune system increasing a patient`s risk to infection. These observations underscore the need for improved, or additional methods of cancer diagnosis and management. We investigated the effect of polysaccharide rich Pleurotus pulmonarius fruit body extracts on progression of chemically induced hepatocellular carcinoma in CBA mice. Addition of Pleurotus pulmonarius extracts in diet delayed progression of carcinogenesis suggesting   that these extracts may be useful as   adjuvants to conventional cancer therapies.   Key words: carcinogenesis; mice; mushroom extracts; pleurotus pulmunarius   Corresponding author: Ms Carolyne Wasonga, Department of Biochemistry, University of Nairobi, P.O. Box 30197, Nairobi,  Kenya. E-mail: carox27@yahoo.ca     Charles O.A. Omwandho, Susanne E. Gruessner, John Falconer, Hans-R Tinneberg, Timothy K. Roberts. IS OVINE PLACENTAL IGG TOXIC TO HUMAN PERIPHERAL BLOOD NATURAL KILLER CELLS?
S PROFIGONSANGWASHIBAIRO. "1993. Effect of deflowering and defoliation during reproductive phase on flower and pod abscission and yield of pigeon peas (Cajanus cajan). Discovery and Innovation, 5: 377-380.". In: Paper submitted in the 3rd International Weed Science Congress in June 2000 at Foz du Iguasu, Brazil. Taylor & Francis; 1993. Abstract
Normal 0 false false false MicrosoftInternetExplorer4 st1:*{behavior:url(#ieooui) } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} Hepatocellular carcinoma results when cancerous cells are localized in the liver. It is distributed globally with high prevalence in sub-Saharan African, southern Asia, China and Japan. Diagnosis is experimental and in many cases inaccurate due to unreliability of markers. Prognosis is poor and the cost of treatment prohibitive. Conventional radiation and chemotherapy lead to loss of hair, fertility and general weakening of the body`s immune system increasing a patient`s risk to infection. These observations underscore the need for improved, or additional methods of cancer diagnosis and management. We investigated the effect of polysaccharide rich Pleurotus pulmonarius fruit body extracts on progression of chemically induced hepatocellular carcinoma in CBA mice. Addition of Pleurotus pulmonarius extracts in diet delayed progression of carcinogenesis suggesting   that these extracts may be useful as   adjuvants to conventional cancer therapies.   Key words: carcinogenesis; mice; mushroom extracts; pleurotus pulmunarius   Corresponding author: Ms Carolyne Wasonga, Department of Biochemistry, University of Nairobi, P.O. Box 30197, Nairobi,  Kenya. E-mail: carox27@yahoo.ca     Charles O.A. Omwandho, Susanne E. Gruessner, John Falconer, Hans-R Tinneberg, Timothy K. Roberts. IS OVINE PLACENTAL IGG TOXIC TO HUMAN PERIPHERAL BLOOD NATURAL KILLER CELLS?
S PROFKIGONDUCHRISTINE. "Sang CK, Kigondu CS, Muchiri L.Correlation between cytology and thyroid function test.East Afr Med J. 2006 Oct;83(10):533-8. PMID: 17310678 [PubMed - indexed for MEDLINE].". In: East Afr Med J. 2006 Oct;83(10):533-8. uon press; 2006. Abstract
BACKGROUND: Thyroid dysfunction can be evaluated by measuring serum thyroid stimulating hormone (TSH), total tri-iodothyronine (T3) and total thyroxine (T4) which will establish euthyroidism, hyperthyroidism and hypothyroidism. Fine needle aspiration (FNA) is the diagnostic test of choice in determining whether a nodule is benign or malignant. OBJECTIVE: To correlate hormonal levels to FNA cytologic findings. DESIGN: A cross-sectional study. SETTING: Kenyatta National Hospital (KNH). RESULTS: Forty two patients had their thyroid profiles done and the results were correlated with FNA diagnosis. Majority of patients had nodular goiter (83.3%), of which 47.6% had euthyroidism, 16.7% had biochemical euthyroidism, 11.9% had hyperthyroidism, 4.8% had sub-clinical hyperthyroidism and 2.4% had sub-clinical hypothyroidism. Three patients (7.1%) with FNA diagnosis of non-diagnostic sample had euthyroidism while 2.4% each with papillary carcinoma, thyroglossal cyst, and atypia, had a hormonal profile of euthyroidism. There was no significant statistical difference (p > 0.05) of the mean levels of T4 (0.406), T3 (0.311), and TSH (0.90), between and within the various groups of FNA cytological diagnoses. CONCLUSION: The study showed that there was no correlation between T4, T3, and TSH measurements and FNA cytological diagnoses.
S PROFKIGONDUCHRISTINE. "Ataya, W.M.. Sekadde-Kigondu C.B., Ruminjo J.K., Wanjala S.M., Munyao G. The onset of spermaturia and the development of Pubertal changes among urban boys in Kenya. J. Obstet, Gynaecol. E.C. Afric 15 (1) 19 (1999).". In: J. Obstet, Gynaecol. E.C. Afric 15 (1) 19 (1999). uon press; 1999. Abstract
OBJECTIVE: To determine if women receiving intrauterine devices (IUCDs) outside of menses have an acceptable rate of insertion problems and subsequent IUCD-related complications. DESIGN: Cross-sectional and prospective cohort study of insertions at times other than during menses. SETTING: The study was carried out in two government family planning (FP) clinics in Nairobi, Kenya. SUBJECTS: After appropriate pre-test and post-test HIV counselling, 1686 women requesting IUCDs at two FP clinics between 1994 and 1995 in Nairobi were enrolled at baseline into a study examining the effect of human immuno-deficiency virus (HIV) infection on IUCD-related complications. Six hundred and forty nine women (156 HIV-infected and 493 HIV-uninfected) were selected for the four month follow up study. They were classified according to their menstrual cycle status at time of IUCD insertion. MAIN OUTCOME MEASURES: Problems at the time of insertion (pain, bleeding, immediate expulsion) and IUCD-related complications through four months. RESULTS: Rates of immediate insertion problems were low in the women who had insertions during menses (7.0%), outside of menses (4.0%) or had oligomenorrhea/amenorrhea (2.6%). The adjusted odds ratios for IUCD insertion problems outside of menses and in oligomenorrhea/amenorrhea (versus women with insertion during menses) were 0.54 (95 % CI 0.18-1.59) and 0.39 (95% CI 0.12-1.29) respectively. IUCD-related complications were higher in the oligomenorrhea/amenorrhea (11.5%) or insertion outside of menses (6.9%), than the within menses (4.3%) groups. However, the differences were not statistically significant. Adjusted odds ratios for IUCD outside of menses and oligomenorrhoea/amenorrhea groups were 1.65 (95% CI 0.21-12.91) and 2.72 (95% CI 0.34-21.71) respectively. CONCLUSION: The results confirm that the IUCD can be safely inserted outside of menses with minimal insertion difficulties and subsequent complications. Availability of IUCDs outside of menses may enhance IUCD acceptance in Kenya and create better opportunity for visual screening of the cervix for sexually transmitted infections.
S PROFMASINDEMICHAEL. "Datta, P., Frost E., Peeling, R., Masinde, M. S., Deslandes, S., Echelu, C., Wamola, I., Brunham, R.C. Ophthalmia neonatorum in a trachoma Endemic area. Sex Transm Dis. 21 (1): 1 .". In: Sex Transm Dis. 21 (1): 1 .; 1994. Abstract
OBJECTIVE: To determine the prevalence of Xerophthalmia among Kenyan children aged four to seven years in high risk using Conjuctival Impression Cytology and transfer. DESIGN: A cross sectional community based study. SETTING: Mathare slum in Nairobi and Tiva/Ithiani area of Kitui. SUBJECTS: Children aged four to seven years residing in the above areas were assessed for both clinical and cytological features of vitamin A deficiency. RESULTS: Of the 342 children included in this study, 316 (92.0%) were normal, five (1.5%) had XN, 19 (5.9% had XIA and two (0.6%) had XIB. No signs of corneal Xerophthalmia were seen in this study. Conjuctival impression cytology and transfer (CICT) was used to asses for squamous metaplastic changes associated with Vitamin A deficiency (VAD). Seventy five (23.1%) of the children were normal by CICT while 249 (76.9%) were abnormal. In comparing the two areas of study, only 13.2% of the children in Mathare had normal CICT compared to 50% in Kitui. For each of the age groups studied there was significant difference between the two areas with children from Mathare being more deficient than those from Kitui. CONCLUSION: VAD is a significant health problem in the high risk areas assessed by CICT in this study.
S PROFKIGONDUCHRISTINE. "Pharmacodynamic effects of depot-medroxyprogesterone acetate (DMPA) administered to lactating women on their male infants. Contraception. 1996 Sep;54(3):153-7.". In: Int J STD AIDS. 1996 Jan-Feb;7(1):65-70. uon press; 1996. Abstract
Normal postpartum women, who had a spontaneous vaginal delivery of one full-term male infant, free of congenital abnormalities and other diseases, were recruited for this study. Thirteen women received 150 mg depot-medroxy-progesterone acetate (DMPA), intramuscularly on days 42 + 1 and 126 + 1 postpartum. Infants of nine mothers, who did not receive DMPA, served as controls. Blood samples were collected from treated mothers on days 44, 47, 74, 124, 128, and 130 postpartum for medroxyprogesterone acetate (MPA) measurements. Four-hour urine collections were obtained from all 22 infants in the morning on days 38, 40, 42, 44, 46, 53, 60, 67, 74, 88, 102, 116, 122, 124, 126, 128, 130, and 137. Urinary follicle stimulating hormone (FSH), luteinizing hormone (LH), unconjugated testosterone, and unconjugated cortisol were measured by radioimmunoassay, and serum MPA and urinary MPA metabolites were measured by gas chromatography-mass spectrometry (GC-MS). No MPA metabolites could be detected in the urine of the infants from the DMPA-receiving mothers. Hormonal profiles in the urine samples were not suppressed in comparison with those of the control infants. The present study demonstrates that DMPA, administered to the mother, does not influence the hormonal regulation of the breast-fed normal male infant.
S PROFOLIECHJOSEPH. "One stage repair of urethral strictures at the Kenyatta National Hospital (1978-1984).". In: East Afr Med J. 1988 Jan;65(1):39-47. PROF.J.S.OLIECH; 1988. Abstract
No abstract available yet
S PROFKIGONDUCHRISTINE. "Thagana N.G., Sekadde-Kigondu C.B., et al .Aetiological factors associated with Azoospermia at Kenyatta National Hospital. J. Obstet Gynaecol. E. and Central . Afr. 6 (2), 87, 1987.". In: J. Obstet Gynaecol. E. and Central . Afr. 6 (2), 87, 1987. uon press; 1987. Abstract

PIP: The effects of the triphasic oral contraceptive (OC) ethinyl estradiol (EE) and levonorgestrel (LNG) on lipid and lipoprotein metabolism were evaluated in 97 black Kenyan women. Subjects were recruited from the Family Planning Clinic and were followed for 12 months. There was an increase in fasting levels of total cholesterol. These changes were not statistically significant. However, the triglyceride increase was statistically significant at 9 months and 12 months (p0.05). The high density cholesterol remained unchanged. Thus, this triphasic OC was found to have minimal effect on lipid and lipoprotein metabolism. author's modified

S PROFKIGONDUCHRISTINE. "Achapa C.O., Sekadde-Kigondu C.B., Lequin R.M., Mati J.K.G., Njoroge J.K. Dynamic study follow up of pituitary reserve function in patients who had suffered postpartum haemorrhage J. Obstet Gynaecol. E. and Central Afr. 2:166, 1983.". In: J. Obstet Gynaecol. E. and Central Afr. 2:166, 1983. uon press; 1983. Abstract
PIP: Menstrual blood loss (MBL) was evaluated in 74 nulliporous Kenyan women aged between 20 and 27 years. The hemoglobin levels were all in normal range with the mean of 13.65 +or- 0.8, 13.84 +or- 1.2 and 13.04 +or- 1.2 g/100 ml respectively in 3 populations. The MBL was comparable in the 3 populations with the mean of 35.1 +or- 12.6, 30.6 +or- 8.7 and 32.2 +or- 9.4 ml respectively. There was no difference of statistical significance between the 2 periods studied per each individual. This study objectively assesses the menstrual blood loss in 3 population groups–2 urban and 1 rural. The data can be used to evaluate menstrual blood loss before and after initiation of various contraceptives used in Kenya. Subjects were volunteers who were not on any contraception except barrier or natural rhythm methods, not under psychological stress and who exhibited normal physical female characteristics on examination. Those who wished to drop out, became pregnant or desired contraception, were excluded. The study confirms the individual constancy of the menstrual blood loss in this population. This has important practical implications since a single determination of the menstrual blood loss may be a fairly good expression for the average blood loss in a woman. The immediate effect of various treatments such as IUD insertion or oral contraceptives on the MBL may easily be evaluated quantitatively by measurements in consecutive periods using only 1 period as a control. The quick method can be easily used in evaluating pathological conditions e.g. iron-deficiency due to heavy bleeding, IUD-associated hemorrhage, menorrhagia and uterine fibroid.
S PROFIGONSANGWASHIBAIRO. "Effects of recharging on moisture loss and quality changes during short term storage of sweet potato (Ipomea batata L.). Botswana Journal of Agriculture and Applied Sciences, 2: 67-78.". In: Journal of Plant Nutrition. Taylor & Francis; 2006. Abstract
Normal 0 false false false MicrosoftInternetExplorer4 st1:*{behavior:url(#ieooui) } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} Hepatocellular carcinoma results when cancerous cells are localized in the liver. It is distributed globally with high prevalence in sub-Saharan African, southern Asia, China and Japan. Diagnosis is experimental and in many cases inaccurate due to unreliability of markers. Prognosis is poor and the cost of treatment prohibitive. Conventional radiation and chemotherapy lead to loss of hair, fertility and general weakening of the body`s immune system increasing a patient`s risk to infection. These observations underscore the need for improved, or additional methods of cancer diagnosis and management. We investigated the effect of polysaccharide rich Pleurotus pulmonarius fruit body extracts on progression of chemically induced hepatocellular carcinoma in CBA mice. Addition of Pleurotus pulmonarius extracts in diet delayed progression of carcinogenesis suggesting   that these extracts may be useful as   adjuvants to conventional cancer therapies.   Key words: carcinogenesis; mice; mushroom extracts; pleurotus pulmunarius   Corresponding author: Ms Carolyne Wasonga, Department of Biochemistry, University of Nairobi, P.O. Box 30197, Nairobi,  Kenya. E-mail: carox27@yahoo.ca     Charles O.A. Omwandho, Susanne E. Gruessner, John Falconer, Hans-R Tinneberg, Timothy K. Roberts. IS OVINE PLACENTAL IGG TOXIC TO HUMAN PERIPHERAL BLOOD NATURAL KILLER CELLS?
S MRWANYAMAJOSEPH. Mpuonzi's Dream, a Novel.. Nairobi: Africawide Network; 1999.Website
S PROFIGONSANGWASHIBAIRO. "A study of postharvest moisture loss in carrots (Daucus carota l.) during short-term storage. Ph.D Thesis, The University of British Columbia, Canada, 1996.". In: Paper submitted in the 3rd International Weed Science Congress in June 2000 at Foz du Iguasu, Brazil. Taylor & Francis; 1996. Abstract
Normal 0 false false false MicrosoftInternetExplorer4 st1:*{behavior:url(#ieooui) } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} Hepatocellular carcinoma results when cancerous cells are localized in the liver. It is distributed globally with high prevalence in sub-Saharan African, southern Asia, China and Japan. Diagnosis is experimental and in many cases inaccurate due to unreliability of markers. Prognosis is poor and the cost of treatment prohibitive. Conventional radiation and chemotherapy lead to loss of hair, fertility and general weakening of the body`s immune system increasing a patient`s risk to infection. These observations underscore the need for improved, or additional methods of cancer diagnosis and management. We investigated the effect of polysaccharide rich Pleurotus pulmonarius fruit body extracts on progression of chemically induced hepatocellular carcinoma in CBA mice. Addition of Pleurotus pulmonarius extracts in diet delayed progression of carcinogenesis suggesting   that these extracts may be useful as   adjuvants to conventional cancer therapies.   Key words: carcinogenesis; mice; mushroom extracts; pleurotus pulmunarius   Corresponding author: Ms Carolyne Wasonga, Department of Biochemistry, University of Nairobi, P.O. Box 30197, Nairobi,  Kenya. E-mail: carox27@yahoo.ca     Charles O.A. Omwandho, Susanne E. Gruessner, John Falconer, Hans-R Tinneberg, Timothy K. Roberts. IS OVINE PLACENTAL IGG TOXIC TO HUMAN PERIPHERAL BLOOD NATURAL KILLER CELLS?
S PROFKIGONDUCHRISTINE. "Njoroge GK, Njagi EN, Orinda GO, Sekadde-Kigondu CB, Kayima JK. Environmental and occupational exposure to lead. East Afr Med J. 2008 Jun;85(6):284-91.". In: East Afr Med J. 2002 Mar;79(3):163-4. uon press; 2008. Abstract
OBJECTIVE: To determine the status of environmental and occupational lead exposure in selected areas in Nairobi, Kenya. DESIGN: Cross sectional study. SETTING: Kariobangi North, Babadogo, Waithaka and Pumwani for assessment of environmental exposure to lead (Pb) and Ziwani Jua Kali works for assessment of occupational lead exposure. Olkalou in Nyandarua District was the covariate study area. SUBJECTS: Three hundred and eight children and adults participated. RESULTS: Blood lead levels (BLLs) obtained for the entire sample (n = 308) ranged from 0.4 to 65 microg/dl of blood. One hundred and sixty nine (55%) of the total sample had levels equal to or below 4.9 microg/dl, while 62 (20%) of the sample had levels ranging from 5.0 to 9.9 microg/dl. Blood lead levels above 10 microg/dl were recorded in 77 (25%) of the total sample. Within Nairobi, 32 (15.3%) of the study subjects in areas meant for assessment of environmental lead exposure had levels above the WHO/CDC action levels of 10 microg/dl of blood. The mean BLL for the occupationally exposed (Ziwani Jua kali) was 22.6 +/- 13.4 microg/dl. Among the workers, 89% had BLLs above 10 microg/dl. In general, 15% of the entire sample (for both environmental and occupational groups) in Nairobi had BLLs above 15 microg/dl. The covariate group at Olkalou had a mean BLL of 1.3 +/- 0.9 microg/dl. CONCLUSION: The prevalence of environmental lead exposure to the general public is high in Nairobi compared to Olkalou where non exposure was reported. Occupational lead exposure has been identified to be at alarming levels and urgent intervention measures are recommended.
S MKSOG. "Polycystic kidney disease in a patient with achondroplasia: case report." East African Medical Journal. 2003; 80(1):56 - 58. 2003. AbstractWebsite

Department of Medicine, College of Health Sciences, University of Nairobi, P.O. Box 19676, Nairobi, Kenya. Autosomal dominant polycystic kidney disease is a multisystem disease involving many organs. An association with other diseases such as tuberous sclerosis, von Hippel-Lindau disease and Marfan syndrome have been previously described. We describe a 35 year old female with achondroplasia who developed polycystic kidney disease involving both kidneys and progressing to end-stage renal disease. To the best of our knowledge this is the first such case described in the literature. We also delve, briefly, into the possibility of the genes and chromosomes involved in Marfan syndrome, polycystic kidney disease, tuberous sclerosis and achondroplasia playing a role in the co-occurrence of these entities.

S K, A K, J N, E K, C S, J.M OK, Mengich G. "Roles Of Medical Educators In The Advancement Of Health Professions.". 2012. Abstract

Health care professionals are absorbed daily in the practices of their professional areas of specialization. Pediatricians, for example spend most of their time catering to the needs of children, while nurses, pharmacists and dentists in their own areas. Medical Educators, however, spend their time catering to the educational needs of all health care professionals, whatever their specialization. A recent area of concern in the medical education curricula has been the inclusion of the topic

S PROFKIGONDUCHRISTINE. "P. Gichangi, Forick K., Sekadde-Kigondu C.B., Ndinya-Achola J, Bwayo J, Kiragu D., Claeyo P., Temmerman M. Partner notification of pregnant women infected with syphilis in Nairobi, Kenya. Int. J. of STDs and AIDS 11 257, 2000.". In: Int. J. of STDs and AIDS 11 257, 2000. uon press; 2000. Abstract
Reproductive Biology Unit, Department of Animal Physiology, University of Nairobi, Kenya. dochiel@kisian.mimcom.net The presence of human immunodeficiency virus (HIV) in genital secretions is regarded as a risk factor for sexual and perinatal transmission of HIV. A better understanding of correlates of genital shedding of HIV is crucial to the development of effective strategies against transmission of this virus. Events during menstrual cycle are likely to influence local immune responses and viral load in genital secretions, and hence determine susceptibility to HIV or efficiency of virus transmission. We report, in this study, preliminary findings on the relationship of menstrual cycle to genital mucosal and systemic immunity in female olive baboons (Papio anubis) experimentally inoculated with simian/human immunodeficiency virus (SHIV)89.6P.
S PROFMASINDEMICHAEL. "New trends in ocular Aids in children submitted to E.A.J.O. 2005.". In: E.A.J.O. 2005.; 2005. Abstract
Objectives: To describe the pattern of ocular abnormalities, their correlation with the physical disorders and describe associated risk factors in children attending the Occupational therapy clinic at Kenyatta National Hospital.   Design: Cross sectional hospital based.   Subjects: A hundred and eighty seven children, aged between three months and 13 years with cerebral palsy and sensory integration deficits.   Results: Majority of the patients had cerebral palsy(CP), 160(85.6%), while in those with sensory integration deficit(SID), attention- deficit / hyperactive disorder and autism had almost equal proportions, 20(10.7%) and 18(9.6%) respectively. Among all the children, 62% had ocular anomalies. Children with CP had a much higher prevalence (58.3%) compared to SID group (3.7%). The common ocular abnormalities included cortical visual impairment (48.7%), refractive errors (39%) and squints (34.2%). Association between physical disability and ocular anomalies was noted more in patients with CP compared with SID. Strabismus, cortical visual impairment and myopia were more likely to occur in patients with CP. Significant hyperopia was noted only in CP patients. Strabismus and cortical visual impairment were more likely to occur in patient with neonatal jaundice, while refractive errors in patients with congenital causes and optic atrophy in patients with meningitis.   Conclusion: Visual disabilities in children with physical disabilities were common. Cortical visual impairment, refractive errors and squints were more common. Children with CP had a much higher prevalence compared to the SID group.   Recommendation: All Children with CP and SID should be referred to ophthalmologist and low vision specialist for assessment.
S PROFKIGONDUCHRISTINE. "Kamau, R.K., Karanja, J.K,. Sekadde-Kigonu, C.B., Ruminjo, J.K., Nichols, D., et al. Identifying Barriers to Contraceptive Use in Kenya, E.A. Med J. 73:651, 1996.". In: E.A. Med J. 73:651, 1996. uon press; 1996. Abstract
This pilot study aimed to determine the feasibility of a larger study of contraception and risk of HIV infection in women. We also measured risk factors for and occurrence of HIV infection in the participants. A cohort of 1537 seronegative women attending a family planning clinic in Nairobi, Kenya was enrolled and followed for up to 12 months per woman. HIV testing was done quarterly. A nested case-control analysis was done with seroconverting women (cases) and 3 matched controls per case, who had detailed interviews and received physical examinations and STD tests. The prevalence of HIV at enrollment was 6.1%; seropositive women were excluded from further analysis. The 12-month life-table cumulative incidence of HIV was 2.1 per 100 women (95% confidence interval [CI] 1.1-3.2). In the nested case-control analysis (17 cases and 51 controls), the crude odds ratio of HIV infection comparing oral contraceptive (OC) users with other women was 3.5 (95%) CI 0.8-21.5), which persisted after control for single confounders at a time. The putative association between OC use sand HIV infection is critical to public health policy, yet no study has been conducted specifically to measure it, yielding weak and conflicting evidence. We intend to conduct a larger study with a similar design as the current pilot study, which confirmed the feasibility of a more definitive project.
S PROFKIGONDUCHRISTINE. "Quereshi ZP, Sekadde-kigondu CB. A survey to determine the knowledge, attitudes and practice of family planning amongst the nursing staff at Kenyatta National Hospital. J Obstet Gynaecol East Cent Africa. 1991;9(1):49-51.". In: J. Obstet. Gynaecol E.and Centr. Afric 9:49, 1991. uon press; 1991. Abstract

PIP: This survey was conducted at the Kenyatta National Hospital between March-June 1988 to assess the attitudes, basic knowledge and personal use of contraceptives among the nursing staff and to determine how these would influence family planning utilization in the country. In 1987, a similar survey was conducted among the physicians at this same hospital. A total of 432 nurses were interviewed; 64.4% of the nurses were currently using contraceptives and 7.7% had used them continuously. The IUD was used by 47.1% of the nurses. 62.3% of the nurses indicated that they would be able to discuss contraceptive use with their teenage daughters but only 29.6% would provide contraceptives. 66.7% of the nurses had extensive knowledge of contraceptives (over 60% knowledge) but knowledge concerning male contraceptives and newer methods such as Norplant was poor. author's modified

S PROFOLIECHJOSEPH. "Urethral strictures, treatment by one stage urethroplasty. (press).". In: East Afr Med J. 1979 Jan;56(1):40-1. PROF.J.S.OLIECH; 1978. Abstract
No abstract available yet.
S PROFKIGONDUCHRISTINE, W MRMAINAFRANCIS. "Ojwang PJ, Ogada T, Maina FW, Sekadde-Kigondu CB, Mati JK. Reference values for serum lipids and lipoprotein cholesterol in adults and cord blood of Kenyan Africans. East Afr Med J. 1984 May;61(5):367-71.". In: J. Obstet. Gynaecol. E. and Central Afr. 3:167, 1984. uon press; 1984. Abstract
No abstract available.
S PROFKIGONDUCHRISTINE. "Lutalo-Bosa A.J., Sekadde C.B., Opiyo W. and Kiwanuka J.B., Presentation of paper to the Annual Scientific Conference of East Africa Medical Research Council, February, 1977 Liver function tests among normal Ugandans. A paper was reported in the Annual Re.". In: Annual Scientific Conference of East Africa Medical Research Council. uon press; 1977. Abstract

PIP: Masturbatory semen specimen from 49 fertile Black African males in Kenya whose wives were pregnant was obtained after at least 3 days of abstinence for the analysis of parameters which included volume motility, vitality, sperm concentration, pH, fructose and acid phosphatase levels. About 1/2 the spermatozoa was actively progressive in motility, while 40% was nonmotile. Vitality in the 1st hour revealed that 81.4% of the sperm was alive. About 90% of the semen specimens had more than 40% idea forms of spermatozoa. Spermatozoal abnormalities were a frequent feature. There was no correlation between age and the testicular volume, but seminal fluid volume and sperm density tended to decrease with age. Serum levels of Follicle Stimulating Hormone, Luteinizing Hormone, Prolactin and Testosterone were determined in the subjects' sera, enabling the establishment of reference values for these parameters in African Kenyan males.

S PROFIGONSANGWASHIBAIRO. "Effect of source, time and method of nitrogen application on growth and yield components of potato in Kenya. African Crop Science Journal, 8(4): 387-402.". In: Poster presented at the fifth Regional meeting of the Forum for Agricultural Resource Husbandry 12-16 August 2002,Entebbe. Taylor & Francis; 2000. Abstract
Normal 0 false false false MicrosoftInternetExplorer4 st1:*{behavior:url(#ieooui) } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} Hepatocellular carcinoma results when cancerous cells are localized in the liver. It is distributed globally with high prevalence in sub-Saharan African, southern Asia, China and Japan. Diagnosis is experimental and in many cases inaccurate due to unreliability of markers. Prognosis is poor and the cost of treatment prohibitive. Conventional radiation and chemotherapy lead to loss of hair, fertility and general weakening of the body`s immune system increasing a patient`s risk to infection. These observations underscore the need for improved, or additional methods of cancer diagnosis and management. We investigated the effect of polysaccharide rich Pleurotus pulmonarius fruit body extracts on progression of chemically induced hepatocellular carcinoma in CBA mice. Addition of Pleurotus pulmonarius extracts in diet delayed progression of carcinogenesis suggesting   that these extracts may be useful as   adjuvants to conventional cancer therapies.   Key words: carcinogenesis; mice; mushroom extracts; pleurotus pulmunarius   Corresponding author: Ms Carolyne Wasonga, Department of Biochemistry, University of Nairobi, P.O. Box 30197, Nairobi,  Kenya. E-mail: carox27@yahoo.ca     Charles O.A. Omwandho, Susanne E. Gruessner, John Falconer, Hans-R Tinneberg, Timothy K. Roberts. IS OVINE PLACENTAL IGG TOXIC TO HUMAN PERIPHERAL BLOOD NATURAL KILLER CELLS?
S PROFKIGONDUCHRISTINE. "EgziabhleTekle, J.K.Ruminjo and C.B. Sekadde-Kigondu. Pain relief using Paracervical block in patients undergoing manual vacuum aspiration of the uters. E.A.M.J vol 79 (10) 530, 2002.". In: E.A.M.J vol 79 (10) 530, 2002. uon press; 2002. Abstract
Reproductive Biology Unit, Department of Animal Physiology, University of Nairobi, Kenya. dochiel@kisian.mimcom.net The presence of human immunodeficiency virus (HIV) in genital secretions is regarded as a risk factor for sexual and perinatal transmission of HIV. A better understanding of correlates of genital shedding of HIV is crucial to the development of effective strategies against transmission of this virus. Events during menstrual cycle are likely to influence local immune responses and viral load in genital secretions, and hence determine susceptibility to HIV or efficiency of virus transmission. We report, in this study, preliminary findings on the relationship of menstrual cycle to genital mucosal and systemic immunity in female olive baboons (Papio anubis) experimentally inoculated with simian/human immunodeficiency virus (SHIV)89.6P.
S P, Simiyu BN, JY S, K T, FI W, KG DL, GES D, LV I. "Management of Mandibular Lateral Incisors with Vertucci Type II Canal Configuration." Journal of the Endodontic Society of the Philippines . 2018;11:19-23.
S PROFKIGONDUCHRISTINE. "Kasilima Y.S., Wango E.O., Mutayoba B.M., Sekadde-Kigondu C.B., Mola P, Winga J, Odongo H. Schistosoma Mansoni. New Zealand Rabit - Model. Effect on Plasma Testosterone levels. Tanzanian Vet J. Vol 17, 148, 1997.". In: Tanzanian Vet J. Vol 17, 148, 1997. uon press; 1997. Abstract
Aga Khan Hospital, Nairobi. Forty females, age 14 to 35 years (mean 28.6 years) with chronic renal failure (CRF) were included in the study. Their menstrual patterns were noted. The function of their hypothalamo-pituitary-ovarian axis was assessed by the serum levels of follicle stimulating hormone (FSH), Luteinising hormone (LH), prolactin (PrL), estradiol (E2) and progesterone (P) at different phases of the menstrual cycle in patients who continued to have normal menses (Group 1) and at weekly intervals for six weeks in patients with menstrual disturbances (Group II). The mean hormone levels during the initial contact Luteal phase in group I were FSH 12.0 IU/L (N, 1.0-3.0 IU/L), LH 1.8IU/L (N 1.5-101U/L), PrL 652mIU/L (N, 100-600 mIU/L) mE2 160 pmol/L (N 400-1400 pmol/L) and P5 nmol/L (N 14-60 nmol/L) for group I. Corresponding values for group II were 1.2, 10.3, 250, 600 and 3.0 in relevant units. All patients (fourteen) with end stage renal disease (ESRD) had amenorrhoae. On the other hand, most patients with stable CRF (22/26) had normal menses. Following initiation of therapy (conservative or dialytic), there was no significant alteration in the hormonal profile or menstrual pattern. We conclude that other factors apart from the hormonal imbalances, may be responsible for the menstrual disturbances noted in patients with CRF.
S DRKARANJAHDOMINIC. "Karanja D.S .". In: The Limnology, Climatology and Palaeoclimatology of the East African Lakes pp. 413-431, Gordon and Breach Publishers, Amsterdam. June 1996 b) Books Reference Date. Earthscan, London. 978-1-84407-469-3 (*); 1984. Abstract
n/a
S PROFKIGONDUCHRISTINE. "Rogo K., Onyango, G. Ojwang, P.J. and Sekadde-Kigondu , C.B. Maternal levels of alpha- feto protein in African Women E. Afr. Med J. 68: 601, 1991.". In: E. Afr. Med J. 68: 601, 1991. uon press; 1991. Abstract
Forty females, age 14 to 35 years (mean 28.6 years) with chronic renal failure (CRF) were included in the study. Their menstrual patterns were noted. The function of their hypothalamo-pituitary-ovarian axis was assessed by the serum levels of follicle stimulating hormone (FSH), Luteinising hormone (LH), prolactin (PrL), estradiol (E2) and progesterone (P) at different phases of the menstrual cycle in patients who continued to have normal menses (Group 1) and at weekly intervals for six weeks in patients with menstrual disturbances (Group II). The mean hormone levels during the initial contact Luteal phase in group I were FSH 12.0 IU/L (N, 1.0-3.0 IU/L), LH 1.8IU/L (N 1.5-101U/L), PrL 652mIU/L (N, 100-600 mIU/L) mE2 160 pmol/L (N 400-1400 pmol/L) and P5 nmol/L (N 14-60 nmol/L) for group I. Corresponding values for group II were 1.2, 10.3, 250, 600 and 3.0 in relevant units. All patients (fourteen) with end stage renal disease (ESRD) had amenorrhoae. On the other hand, most patients with stable CRF (22/26) had normal menses. Following initiation of therapy (conservative or dialytic), there was no significant alteration in the hormonal profile or menstrual pattern. We conclude that other factors apart from the hormonal imbalances, may be responsible for the menstrual disturbances noted in patients with CRF.
S G, E EH, W. A. "Understanding as a Concept in Education: Conceptions and Alternative Interpretations." Journal of Educational and Social Research. 2014;4(1):339-344. Website
S PROFOLIECHJOSEPH. "Pyogenic thyroiditis at KNH. E.A. Med. J. VOl. 56 No. 1, 1979.". In: E.A. Med. J. VOl. 56 No. 1, 1979. PROF.J.S.OLIECH; 1979. Abstract

No abstract yet SUMMARY.

Although pyogenic thyroiditis is rare,the four cases have been seen and treated at Kenyatta National Hospital (KNH) over the last 10 years.This is a report of one of these cases detailing the clinical presentation and operative findings.
A middle aged female with a large painful shining anterior neck swelling of 4days duration.She had difficulty of swallowing,but no dyspnoea.She was febrile,with moderate anaemia, polymorph-leucocytosis (52%)and lymphocytosis(36%).Thyroid immunoglobulins were unavailable.131 iodine uptake studies was reduced,plain x-ray of the trachea/neck was unremarkable.
A thick suppurative pus from the left lobe grew on organisms.The discusses various forms of thyroid abcesses ,their causes and treatment.

S PROFKIGONDUCHRISTINE. "Gachara M.N., Sekadde-Kigondu C.B., Muitta M.N. Mati J.K.G. J. Obstet. Gynaecol. E. Central. Afr. 3:19, 1984 The role of antisperm antibodies in infertility in Kenya.". In: J. Obstet. Gynaecol. E. Central. Afr. 3:19, 1984. uon press; 1984. Abstract

PIP: 125 black Kenyan women attending the Kenyatta National Family Welfare Clinic were randomly allocated to combined and fixed dose oral contraceptives (Eugynon: 500 mcg dl-norgestrel + 50 mcg ethinyl estradiol or Microgynon: 150 mcg levonorgestel + 30 mcg ethinyl estradiol). They were between 18-33 years of age with a mean of 25 +or- 7 years. The mean parity of this group was 3 and they had a mean education standard of 8 years. Fasting blood sampled were taken on recruitment (control cycle) and thereafter once for cycles 1, 3, 6, 9, and 12 during OC use. HDL-cholesterol was estimated in the sear. The 2 OCs elicited a significant decrease in levels of HDL-cholesterol (p0.01). author's modified

S PROFKIGONDUCHRISTINE. "Mukasa FR, Sekadde-kigondu CB, Mati JK, Njoroge JK. The pituitary reserve for gonadotrophins and prolactin in women under long-term use of depo-medroxyprogesterone acetate (DMPA) as a contraceptive. J Obstet Gynaecol East Cent Africa. 1982 Dec;1(4):160-3.". In: J. Obs/Gyn. East Central Africa 1:126(1982). uon press; 1982. Abstract
PIP: Pituitary reserve was assessed in women who had used depo-medroxyprogesterone acetate (DMPA) for 1, 5 and 10 years, and their responses were compared to 2 control groups–IUD users and noncontraceptive users. 100 ug GnRH and 200ug TRH were injected as a bolus and the Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH) and Prolaction (PRL) responses noted. The basal PRL levels were similar in all groups. The PRL response to stimulation was significantly greater among 5 and 10 year DMPA users and also IUD users. The mean basal levels of LH were within the normal follicular phase range in all groups. However, the response to stimulation was significantly higher among 1 and 5 year DMPA users when compared with noncontraceptive users. The basal serum FSH levels in both the study and control groups were comparable to those of normally cycling women in the follicular phase. The response to stimulation was greater in the 10 year DMPA users when compared to both the noncontraceptive users and IUD users. The study shows that basal levels of FSH, LH and PRL were similar in the study and control groups. The observed amplified response to stimulation among longterm DMPA users could be the result of failure of gonadotropin cyclic release, possibly resulting in increased pituitary reserves.
S PROFIGONSANGWASHIBAIRO. "Aphid vectors of potato virus diseases in Kenya.". In: Paper presented at the 15th African Association of Insect Scientists and the Entomological Society of Kenya conference. Taylor & Francis; 2003. Abstract
Normal 0 false false false MicrosoftInternetExplorer4 st1:*{behavior:url(#ieooui) } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} Hepatocellular carcinoma results when cancerous cells are localized in the liver. It is distributed globally with high prevalence in sub-Saharan African, southern Asia, China and Japan. Diagnosis is experimental and in many cases inaccurate due to unreliability of markers. Prognosis is poor and the cost of treatment prohibitive. Conventional radiation and chemotherapy lead to loss of hair, fertility and general weakening of the body`s immune system increasing a patient`s risk to infection. These observations underscore the need for improved, or additional methods of cancer diagnosis and management. We investigated the effect of polysaccharide rich Pleurotus pulmonarius fruit body extracts on progression of chemically induced hepatocellular carcinoma in CBA mice. Addition of Pleurotus pulmonarius extracts in diet delayed progression of carcinogenesis suggesting   that these extracts may be useful as   adjuvants to conventional cancer therapies.   Key words: carcinogenesis; mice; mushroom extracts; pleurotus pulmunarius   Corresponding author: Ms Carolyne Wasonga, Department of Biochemistry, University of Nairobi, P.O. Box 30197, Nairobi,  Kenya. E-mail: carox27@yahoo.ca     Charles O.A. Omwandho, Susanne E. Gruessner, John Falconer, Hans-R Tinneberg, Timothy K. Roberts. IS OVINE PLACENTAL IGG TOXIC TO HUMAN PERIPHERAL BLOOD NATURAL KILLER CELLS?
S PROFKIGONDUCHRISTINE. "JK Kyaligonza, EO Wango, C Sekadde-Kigondu and P Adayo The Acrosomee Reaction in Gray Mangbey.". In: J.Med. Primatology., 23, 187, 2003. uon press; 2003. Abstract
The presence of human immunodeficiency virus (HIV) in genital secretions is regarded as a risk factor for sexual and perinatal transmission of HIV. A better understanding of correlates of genital shedding of HIV is crucial to the development of effective strategies against transmission of this virus. Events during menstrual cycle are likely to influence local immune responses and viral load in genital secretions, and hence determine susceptibility to HIV or efficiency of virus transmission. We report, in this study, preliminary findings on the relationship of menstrual cycle to genital mucosal and systemic immunity in female olive baboons (Papio anubis) experimentally inoculated with simian/human immunodeficiency virus (SHIV)89.6P.
S PROFKIGONDUCHRISTINE. "Obwaka, W., Ruminjo, J.K., Ndavi, P.M., Sekadde-Kigondu, C.B., Correlates of Contraceptive failure among clients attending antenatal clinic in Nairobi. E.A.Med. J. 74: 561,1997.". In: E.A.Med. J. 74: 561,1997. uon press; 1997. Abstract

Aga Khan Hospital, Nairobi. Forty females, age 14 to 35 years (mean 28.6 years) with chronic renal failure (CRF) were included in the study. Their menstrual patterns were noted. The function of their hypothalamo-pituitary-ovarian axis was assessed by the serum levels of follicle stimulating hormone (FSH), Luteinising hormone (LH), prolactin (PrL), estradiol (E2) and progesterone (P) at different phases of the menstrual cycle in patients who continued to have normal menses (Group 1) and at weekly intervals for six weeks in patients with menstrual disturbances (Group II). The mean hormone levels during the initial contact Luteal phase in group I were FSH 12.0 IU/L (N, 1.0-3.0 IU/L), LH 1.8IU/L (N 1.5-101U/L), PrL 652mIU/L (N, 100-600 mIU/L) mE2 160 pmol/L (N 400-1400 pmol/L) and P5 nmol/L (N 14-60 nmol/L) for group I. Corresponding values for group II were 1.2, 10.3, 250, 600 and 3.0 in relevant units. All patients (fourteen) with end stage renal disease (ESRD) had amenorrhoae. On the other hand, most patients with stable CRF (22/26) had normal menses. Following initiation of therapy (conservative or dialytic), there was no significant alteration in the hormonal profile or menstrual pattern. We conclude that other factors apart from the hormonal imbalances, may be responsible for the menstrual disturbances noted in patients with CRF.

S PROFMASINDEMICHAEL. "Traumatic and Surgical hyphema at Kenyatta National Hospital, Nairobi. Thesis for M.Med (Ophthalmology) .". In: Thesis for M.Med (Ophthalmology) .; 1983. Abstract
OBJECTIVE: To determine the prevalence of Xerophthalmia among Kenyan children aged four to seven years in high risk using Conjuctival Impression Cytology and transfer. DESIGN: A cross sectional community based study. SETTING: Mathare slum in Nairobi and Tiva/Ithiani area of Kitui. SUBJECTS: Children aged four to seven years residing in the above areas were assessed for both clinical and cytological features of vitamin A deficiency. RESULTS: Of the 342 children included in this study, 316 (92.0%) were normal, five (1.5%) had XN, 19 (5.9% had XIA and two (0.6%) had XIB. No signs of corneal Xerophthalmia were seen in this study. Conjuctival impression cytology and transfer (CICT) was used to asses for squamous metaplastic changes associated with Vitamin A deficiency (VAD). Seventy five (23.1%) of the children were normal by CICT while 249 (76.9%) were abnormal. In comparing the two areas of study, only 13.2% of the children in Mathare had normal CICT compared to 50% in Kitui. For each of the age groups studied there was significant difference between the two areas with children from Mathare being more deficient than those from Kitui. CONCLUSION: VAD is a significant health problem in the high risk areas assessed by CICT in this study.
S DRKARANJAHDOMINIC. "Karanja D. S. The Pharmacists Image in Developing Countries Paper presented at the 4th Commonwealth Pharmaceutical Association Conference March 9 .". In: The Limnology, Climatology and Palaeoclimatology of the East African Lakes pp. 413-431, Gordon and Breach Publishers, Amsterdam. June 1996 b) Books Reference Date. Earthscan, London. 978-1-84407-469-3 (*); 1987. Abstract
n/a
S PROFKIGONDUCHRISTINE. "Rukaria,RM, Sekadde-Kigondu CB and . Oyieke. JB. A knowlegde , attitude and practice survey on contraception among undergraduate female and male students in a university in Kenya.J. Obstet. Gynaecol E.and Centr. Afric 10:65, 1992.". In: J. Obstet. Gynaecol E.and Centr. Afric 10:65, 1992. uon press; 1992. Abstract
Forty females, age 14 to 35 years (mean 28.6 years) with chronic renal failure (CRF) were included in the study. Their menstrual patterns were noted. The function of their hypothalamo-pituitary-ovarian axis was assessed by the serum levels of follicle stimulating hormone (FSH), Luteinising hormone (LH), prolactin (PrL), estradiol (E2) and progesterone (P) at different phases of the menstrual cycle in patients who continued to have normal menses (Group 1) and at weekly intervals for six weeks in patients with menstrual disturbances (Group II). The mean hormone levels during the initial contact Luteal phase in group I were FSH 12.0 IU/L (N, 1.0-3.0 IU/L), LH 1.8IU/L (N 1.5-101U/L), PrL 652mIU/L (N, 100-600 mIU/L) mE2 160 pmol/L (N 400-1400 pmol/L) and P5 nmol/L (N 14-60 nmol/L) for group I. Corresponding values for group II were 1.2, 10.3, 250, 600 and 3.0 in relevant units. All patients (fourteen) with end stage renal disease (ESRD) had amenorrhoae. On the other hand, most patients with stable CRF (22/26) had normal menses. Following initiation of therapy (conservative or dialytic), there was no significant alteration in the hormonal profile or menstrual pattern. We conclude that other factors apart from the hormonal imbalances, may be responsible for the menstrual disturbances noted in patients with CRF.
S PROFOLIECHJOSEPH. "Parathyroid gland tumour (case report). Medicom 1:27, 1980.". In: Medicom 1:27, 1980. PROF.J.S.OLIECH; 1980. Abstract
No abstract yet
S PROFKIGONDUCHRISTINE. "Sekadde-Kigondu C.B., Lequin R.M., Thuo S.J., Mati J.K.G. The use of pregnopost sticks in the detection and monitoring for treatment of Trophoblastic tumors in Kenya. J. Obstet. Gynaecol. E. and Central Afr. 4:41, 1985.". In: J. Obstet. Gynaecol. E. and Central Afr. 4:41, 1985. uon press; 1985. Abstract

PIP: 125 black Kenyan women attending the Kenyatta National Family Welfare Clinic were randomly allocated to combined and fixed dose oral contraceptives (Eugynon: 500 mcg dl-norgestrel + 50 mcg ethinyl estradiol or Microgynon: 150 mcg levonorgestel + 30 mcg ethinyl estradiol). They were between 18-33 years of age with a mean of 25 +or- 7 years. The mean parity of this group was 3 and they had a mean education standard of 8 years. Fasting blood sampled were taken on recruitment (control cycle) and thereafter once for cycles 1, 3, 6, 9, and 12 during OC use. HDL-cholesterol was estimated in the sear. The 2 OCs elicited a significant decrease in levels of HDL-cholesterol (p0.01). author's modified

S PROFKIGONDUCHRISTINE. "Karanja J.K., Gwayi-Chore M.D., Sekadde-Kigondu C.B., et al J. Obstet. Gynaecol. E. Central Afr. 108, 1982. Value of FSH, LH and PRL assays in diagnosis of amenorrhoea.". In: et al J. Obstet. Gynaecol. E. Central Afr. 108, 1982. uon press; 1982. Abstract
PIP: Menstrual blood loss (MBL) was evaluated in 74 nulliporous Kenyan women aged between 20 and 27 years. The hemoglobin levels were all in normal range with the mean of 13.65 +or- 0.8, 13.84 +or- 1.2 and 13.04 +or- 1.2 g/100 ml respectively in 3 populations. The MBL was comparable in the 3 populations with the mean of 35.1 +or- 12.6, 30.6 +or- 8.7 and 32.2 +or- 9.4 ml respectively. There was no difference of statistical significance between the 2 periods studied per each individual. This study objectively assesses the menstrual blood loss in 3 population groups–2 urban and 1 rural. The data can be used to evaluate menstrual blood loss before and after initiation of various contraceptives used in Kenya. Subjects were volunteers who were not on any contraception except barrier or natural rhythm methods, not under psychological stress and who exhibited normal physical female characteristics on examination. Those who wished to drop out, became pregnant or desired contraception, were excluded. The study confirms the individual constancy of the menstrual blood loss in this population. This has important practical implications since a single determination of the menstrual blood loss may be a fairly good expression for the average blood loss in a woman. The immediate effect of various treatments such as IUD insertion or oral contraceptives on the MBL may easily be evaluated quantitatively by measurements in consecutive periods using only 1 period as a control. The quick method can be easily used in evaluating pathological conditions e.g. iron-deficiency due to heavy bleeding, IUD-associated hemorrhage, menorrhagia and uterine fibroid. PMID: 12267056 [PubMed - indexed for MEDLINE]
S PROFIGONSANGWASHIBAIRO. "Susceptibility of sweet potato germplasm to rhizopus soft rot caused by Rhizopus stonifer and Rhizopus oryzae in Kenya. MUARIK Bulletin, 6: 30-34.". In: Proceedings. 6th triennial congress of the African Potato Association (APA). 5-10 April, 2004. Agadir, Morocco. Pp.298-299. Taylor & Francis; 2003. Abstract
Normal 0 false false false MicrosoftInternetExplorer4 st1:*{behavior:url(#ieooui) } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} Hepatocellular carcinoma results when cancerous cells are localized in the liver. It is distributed globally with high prevalence in sub-Saharan African, southern Asia, China and Japan. Diagnosis is experimental and in many cases inaccurate due to unreliability of markers. Prognosis is poor and the cost of treatment prohibitive. Conventional radiation and chemotherapy lead to loss of hair, fertility and general weakening of the body`s immune system increasing a patient`s risk to infection. These observations underscore the need for improved, or additional methods of cancer diagnosis and management. We investigated the effect of polysaccharide rich Pleurotus pulmonarius fruit body extracts on progression of chemically induced hepatocellular carcinoma in CBA mice. Addition of Pleurotus pulmonarius extracts in diet delayed progression of carcinogenesis suggesting   that these extracts may be useful as   adjuvants to conventional cancer therapies.   Key words: carcinogenesis; mice; mushroom extracts; pleurotus pulmunarius   Corresponding author: Ms Carolyne Wasonga, Department of Biochemistry, University of Nairobi, P.O. Box 30197, Nairobi,  Kenya. E-mail: carox27@yahoo.ca     Charles O.A. Omwandho, Susanne E. Gruessner, John Falconer, Hans-R Tinneberg, Timothy K. Roberts. IS OVINE PLACENTAL IGG TOXIC TO HUMAN PERIPHERAL BLOOD NATURAL KILLER CELLS?
S PROFKIGONDUCHRISTINE. "Kasilima YS, Wango EO, Kigondu CS, Mutayoba BM, Nyindo M. Plasma bioactive LH and testosterone profiles in male New Zealand rabbits experimentally infected with Schistosoma mansoni. Acta Trop. 2004 Nov-Dec;92(3):165-72.". In: Acta Trop. 2004 Nov-Dec;92(3):165-72. uon press; 2004. Abstract
Department of Animal Physiology, Reproductive Biology Unit, University of Nairobi, P.O. Box 30197, Nairobi, Kenya. The effects of Schistosoma mansoni (S. mansoni) infection on plasma levels of bioactive luteinising hormone (LH) and testosterone in the New Zealand rabbit model were studied. S. mansoni infection significantly decreased the pulse frequency (P < 0.05), amplitude (P < 0.05), area under LH curve (P < 0.05) and mean plasma LH concentrations (P < 0.05) on days 42 and 70 post-infection, as compared to values for day 14 pre-infection. Areas under the response curves for plasma testosterone levels decreased significantly (P < 0.05) on days 42 and 70 post-infection in infected animals compared to day 14 pre-infection. In the praziquantel-treated group, the levels of LH and testosterone remained unchanged throughout the experimental period. The pulsatile secretion of LH was completely inhibited in S. mansoni-infected animals 70 days post-infection. These results suggest that the effects on reproductive gonadal hormones caused by S. mansoni in the rabbit model may partly be induced by alteration in pituitary synthesis or release of LH.
S S, P D, J.M K,.P G, E G, R.O MMN, Chemining’wa GN, Narla RD. "Effects of gibberellic acid (GA3) on sprouting and quality of potato seed tubers in diffused light and pit storage conditions." Biological Sciences . 2006;6(4):723-733.
S PROFKIGONDUCHRISTINE. "Jeldesa, G.W., Qureshi, Z.P., Sekadde-Kigondu, C.B.,Wanjala, S.M.H., Maternal Mortality in Garissa Provincial Hospital. J. Obstet. Gynaecol. E. and Centre. Afr. 14: 68, 1998.". In: J. Obstet. Gynaecol. E. and Centre. Afr. 14: 68, 1998. uon press; 1998. Abstract
Aga Khan Hospital, Nairobi. Forty females, age 14 to 35 years (mean 28.6 years) with chronic renal failure (CRF) were included in the study. Their menstrual patterns were noted. The function of their hypothalamo-pituitary-ovarian axis was assessed by the serum levels of follicle stimulating hormone (FSH), Luteinising hormone (LH), prolactin (PrL), estradiol (E2) and progesterone (P) at different phases of the menstrual cycle in patients who continued to have normal menses (Group 1) and at weekly intervals for six weeks in patients with menstrual disturbances (Group II). The mean hormone levels during the initial contact Luteal phase in group I were FSH 12.0 IU/L (N, 1.0-3.0 IU/L), LH 1.8IU/L (N 1.5-101U/L), PrL 652mIU/L (N, 100-600 mIU/L) mE2 160 pmol/L (N 400-1400 pmol/L) and P5 nmol/L (N 14-60 nmol/L) for group I. Corresponding values for group II were 1.2, 10.3, 250, 600 and 3.0 in relevant units. All patients (fourteen) with end stage renal disease (ESRD) had amenorrhoae. On the other hand, most patients with stable CRF (22/26) had normal menses. Following initiation of therapy (conservative or dialytic), there was no significant alteration in the hormonal profile or menstrual pattern. We conclude that other factors apart from the hormonal imbalances, may be responsible for the menstrual disturbances noted in patients with CRF.
S PROFMASINDEMICHAEL. "Masinde, M. S. Epidemiology of ocular injuries at Kenyatta National Hospital. East African Journal of Ophthalmology 8: 19 .". In: East African Journal of Ophthalmology 8: 19 .; 1988. Abstract
OBJECTIVE: To determine the prevalence of Xerophthalmia among Kenyan children aged four to seven years in high risk using Conjuctival Impression Cytology and transfer. DESIGN: A cross sectional community based study. SETTING: Mathare slum in Nairobi and Tiva/Ithiani area of Kitui. SUBJECTS: Children aged four to seven years residing in the above areas were assessed for both clinical and cytological features of vitamin A deficiency. RESULTS: Of the 342 children included in this study, 316 (92.0%) were normal, five (1.5%) had XN, 19 (5.9% had XIA and two (0.6%) had XIB. No signs of corneal Xerophthalmia were seen in this study. Conjuctival impression cytology and transfer (CICT) was used to asses for squamous metaplastic changes associated with Vitamin A deficiency (VAD). Seventy five (23.1%) of the children were normal by CICT while 249 (76.9%) were abnormal. In comparing the two areas of study, only 13.2% of the children in Mathare had normal CICT compared to 50% in Kitui. For each of the age groups studied there was significant difference between the two areas with children from Mathare being more deficient than those from Kitui. CONCLUSION: VAD is a significant health problem in the high risk areas assessed by CICT in this study.
S PROFKIGONDUCHRISTINE. "Sekadde-Kigondu C,B, Ogutu C, et al 3. Condom acceptability and use among patient attending a sexually transmitted diseases clinic. J. Obstet Gyneacol for East And Central Africa. 10 (1), 25, 1992.". In: J. Obstet Gyneacol for East And Central Africa. 10 (1), 25, 1992. uon press; 1992. Abstract
Forty females, age 14 to 35 years (mean 28.6 years) with chronic renal failure (CRF) were included in the study. Their menstrual patterns were noted. The function of their hypothalamo-pituitary-ovarian axis was assessed by the serum levels of follicle stimulating hormone (FSH), Luteinising hormone (LH), prolactin (PrL), estradiol (E2) and progesterone (P) at different phases of the menstrual cycle in patients who continued to have normal menses (Group 1) and at weekly intervals for six weeks in patients with menstrual disturbances (Group II). The mean hormone levels during the initial contact Luteal phase in group I were FSH 12.0 IU/L (N, 1.0-3.0 IU/L), LH 1.8IU/L (N 1.5-101U/L), PrL 652mIU/L (N, 100-600 mIU/L) mE2 160 pmol/L (N 400-1400 pmol/L) and P5 nmol/L (N 14-60 nmol/L) for group I. Corresponding values for group II were 1.2, 10.3, 250, 600 and 3.0 in relevant units. All patients (fourteen) with end stage renal disease (ESRD) had amenorrhoae. On the other hand, most patients with stable CRF (22/26) had normal menses. Following initiation of therapy (conservative or dialytic), there was no significant alteration in the hormonal profile or menstrual pattern. We conclude that other factors apart from the hormonal imbalances, may be responsible for the menstrual disturbances noted in patients with CRF.
S PROFOLIECHJOSEPH. "Carcinoma of prostrate management Assoc. Of Surgeons of E.A. proceedings.". In: Assoc. of Surgeons of E.A. proceedings Dec. 1982. PROF.J.S.OLIECH; 1982. Abstract
No abstract yet
S PROFKIGONDUCHRISTINE. "Maina FW, Sekadde-Kigondu CB, Ojwang PJ, Mati JK. Changes in plasma HDL-cholesterol in women using oral contraceptives in Kenya. East Afr Med J. 1987 Jul.". In: E. Afr. Med. J., 64 (7) 442, 1987. uon press; 1987. Abstract

PIP: 125 black Kenyan women attending the Kenyatta National Family Welfare Clinic were randomly allocated to combined and fixed dose oral contraceptives (Eugynon: 500 mcg dl-norgestrel + 50 mcg ethinyl estradiol or Microgynon: 150 mcg levonorgestel + 30 mcg ethinyl estradiol). They were between 18-33 years of age with a mean of 25 +or- 7 years. The mean parity of this group was 3 and they had a mean education standard of 8 years. Fasting blood sampled were taken on recruitment (control cycle) and thereafter once for cycles 1, 3, 6, 9, and 12 during OC use. HDL-cholesterol was estimated in the sear. The 2 OCs elicited a significant decrease in levels of HDL-cholesterol (p0.01). author's modified

S K, Nafukko FM, Ombega JN, Muriuki G. "Training Techniques that work for Professionals." Pharmacotherapy and Drug Information Journal-E.A. Edition. 2000;II(5).
S PROFKIGONDUCHRISTINE. "Obwaka J.M., Mati J.K.G., Lequin R.M.,Sekadde-Kigondu C.B., et al J. Obstet. Gynaecol E and Central Africa Afr. 1:96, 1982. Baseline studies in semen and hormonal parameters in normal Kenyan males.". In: et al J. Obstet. Gynaecol E and Central Africa Afr. 1:96, 1982. uon press; 1982. Abstract
PIP: Menstrual blood loss (MBL) was evaluated in 74 nulliporous Kenyan women aged between 20 and 27 years. The hemoglobin levels were all in normal range with the mean of 13.65 +or- 0.8, 13.84 +or- 1.2 and 13.04 +or- 1.2 g/100 ml respectively in 3 populations. The MBL was comparable in the 3 populations with the mean of 35.1 +or- 12.6, 30.6 +or- 8.7 and 32.2 +or- 9.4 ml respectively. There was no difference of statistical significance between the 2 periods studied per each individual. This study objectively assesses the menstrual blood loss in 3 population groups–2 urban and 1 rural. The data can be used to evaluate menstrual blood loss before and after initiation of various contraceptives used in Kenya. Subjects were volunteers who were not on any contraception except barrier or natural rhythm methods, not under psychological stress and who exhibited normal physical female characteristics on examination. Those who wished to drop out, became pregnant or desired contraception, were excluded. The study confirms the individual constancy of the menstrual blood loss in this population. This has important practical implications since a single determination of the menstrual blood loss may be a fairly good expression for the average blood loss in a woman. The immediate effect of various treatments such as IUD insertion or oral contraceptives on the MBL may easily be evaluated quantitatively by measurements in consecutive periods using only 1 period as a control. The quick method can be easily used in evaluating pathological conditions e.g. iron-deficiency due to heavy bleeding, IUD-associated hemorrhage, menorrhagia and uterine fibroid. PMID: 12267056 [PubMed - indexed for MEDLINE]
S PROFIGONSANGWASHIBAIRO. "Effects of levels and timing of application of gibberelic acid (GA3) on growth and yield components of common beans. The African Crop Science Journal, 12 (2): 123- 131.". In: In press. African Crop Science Proceedings 7: -. Taylor & Francis; 2004. Abstract
Normal 0 false false false MicrosoftInternetExplorer4 st1:*{behavior:url(#ieooui) } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} Hepatocellular carcinoma results when cancerous cells are localized in the liver. It is distributed globally with high prevalence in sub-Saharan African, southern Asia, China and Japan. Diagnosis is experimental and in many cases inaccurate due to unreliability of markers. Prognosis is poor and the cost of treatment prohibitive. Conventional radiation and chemotherapy lead to loss of hair, fertility and general weakening of the body`s immune system increasing a patient`s risk to infection. These observations underscore the need for improved, or additional methods of cancer diagnosis and management. We investigated the effect of polysaccharide rich Pleurotus pulmonarius fruit body extracts on progression of chemically induced hepatocellular carcinoma in CBA mice. Addition of Pleurotus pulmonarius extracts in diet delayed progression of carcinogenesis suggesting   that these extracts may be useful as   adjuvants to conventional cancer therapies.   Key words: carcinogenesis; mice; mushroom extracts; pleurotus pulmunarius   Corresponding author: Ms Carolyne Wasonga, Department of Biochemistry, University of Nairobi, P.O. Box 30197, Nairobi,  Kenya. E-mail: carox27@yahoo.ca     Charles O.A. Omwandho, Susanne E. Gruessner, John Falconer, Hans-R Tinneberg, Timothy K. Roberts. IS OVINE PLACENTAL IGG TOXIC TO HUMAN PERIPHERAL BLOOD NATURAL KILLER CELLS?
S PROFKIGONDUCHRISTINE. "J.K Ruminjo, C.B Sekadde-Kigondu et al. Comparative acceptability of combined and progestin-only contraception injectable contraceptives in Kenya. Contracetion. 72(2005) 138.1: Contraception. 2005 Aug;72(2):138-45.". In: Contraception. 2005 Aug;72(2):138-45. uon press; 2005. Abstract
OBJECTIVE: We compared 12-month continuation rates, menstrual bleeding patterns and other aspects of acceptability between users of Cyclofem and users of Depo-Provera. METHODS: The life-table method was used to calculate quarterly continuation rates. In all, 360 Kenyan women were randomly assigned to one of the two contraceptives. User-satisfaction questionnaires were administered at 6 and 12 months or at discontinuation, whichever occurred first. RESULTS: The 1-year continuation rate was 75.4% for Depo-Provera users versus 56.5% for Cyclofem users (p<.001). Main reasons for discontinuation included difficulty making clinic visits (45.1% for Cyclofem vs. 40% for Depo-Provera), menstrual changes (14.1% vs. 12.5%) and nonmenstrual problems (15.5% vs. 12.5%). None of the Depo-Provera users and 8.5% of the Cyclofem users claimed frequency of visits as the main reason for discontinuation. In all, 70.6% of the Depo-Provera users were amenorrheic after 12 months, as were 20.8% of the Cyclofem users. CONCLUSIONS: The 1-year continuation rate was higher for Depo-Provera than for Cyclofem. There was no important difference in discontinuation rates because of menstrual problems; the difference mainly reflected the frequency of visits required.
S PROFKIGONDUCHRISTINE. "Gichangi PB, Karanja JG, Kigondu CS, Fonck K, Temmerman M. Knowledge, attitudes, and practices regarding emergency contraception among nurses and nursing students in two hospitals in Nairobi, Kenya.Contraception. 1999 Apr;59(4):253-6.". In: Contraception. 1999 Apr;59(4):253-6. uon press; 1999. Abstract
Department of Obstetrics and Gynecology, University of Nairobi, Kenya. medmicro@ken.healthnet.org A cross-sectional descriptive study on knowledge, attitudes, and practice about emergency contraception (EC) was conducted among nurses and nursing students using a self-administered questionnaire. One-hundred-sixty-seven qualified nurses and 63 nursing students completed the questionnaire. Over 95% listed at least one regular contraceptive method but only 2.6% spontaneously listed EC as a contraceptive method, whereas 48% of the respondents had heard of EC. Significantly more nursing students than qualified nurses were familiar with EC. Knowledge about the types of EC, applications, and side effects was poor and 49% of the respondents considered EC as an abortifacient. Of those familiar with EC, 77% approved its use for rape victims and 21% for adolescents and schoolgirls. Only 3.5% of all respondents had personally used EC in the past, 23% of those familiar with EC intend to use it in the future, whereas 53% intend to provide or promote it. The view that EC was abortifacient negatively influenced the decision to use or provide EC in the future. The present findings suggest that the level of knowledge of EC is poor and more information is needed. These findings indicate the potential to popularize emergency contraception in Kenya among nurses and nursing students. PIP: A descriptive research study on knowledge, attitudes and practices with regard to emergency contraception (EC) was conducted using a questionnaire among 167 nurses and 63 nursing students in Nairobi, Kenya. Results revealed that 95% recorded at least one regular contraceptive method. About 48% of the respondents had heard about EC, but only 2.6% had used it. More nursing students than qualified nurses were aware of EC. There was poor knowledge about the types, applications and side effects of EC. Some 49% of the subjects regarded EC as an abortifacient. About 77% of those knowledgeable about EC approved its use for rape victims and 21% for adolescents and schoolgirls. Only about 3.5% had personally used it. Some 23% of those aware of EC intended to use it in the future. About 53% planned to provide or promote it. The perception that EC is abortifacient affected the decision whether to use or provide it. The data imply that there is potential for effective promotion of EC among nurses and nursing students in Kenya.
S PROFMASINDEMICHAEL. "Masinde, M. S., Duku, A. W. Appraisal of Xerophthalmia in selected centres in Kenya E. African Journal of Ophthalmology 8: 7 .". In: E. African Journal of Ophthalmology 8: 7 .; 1992. Abstract
OBJECTIVE: To determine the prevalence of Xerophthalmia among Kenyan children aged four to seven years in high risk using Conjuctival Impression Cytology and transfer. DESIGN: A cross sectional community based study. SETTING: Mathare slum in Nairobi and Tiva/Ithiani area of Kitui. SUBJECTS: Children aged four to seven years residing in the above areas were assessed for both clinical and cytological features of vitamin A deficiency. RESULTS: Of the 342 children included in this study, 316 (92.0%) were normal, five (1.5%) had XN, 19 (5.9% had XIA and two (0.6%) had XIB. No signs of corneal Xerophthalmia were seen in this study. Conjuctival impression cytology and transfer (CICT) was used to asses for squamous metaplastic changes associated with Vitamin A deficiency (VAD). Seventy five (23.1%) of the children were normal by CICT while 249 (76.9%) were abnormal. In comparing the two areas of study, only 13.2% of the children in Mathare had normal CICT compared to 50% in Kitui. For each of the age groups studied there was significant difference between the two areas with children from Mathare being more deficient than those from Kitui. CONCLUSION: VAD is a significant health problem in the high risk areas assessed by CICT in this study.
S O, SK M, FJ G. "Pull-Out Resistance Of 3 Different Plant Species And Their Application In Slope Stabilization Works." Journal Of Engineering Indian Centre For Advanced Scientific And Technological Research ” (Icastor ) . 2012;Volume 5( No. 1 ).pull-out_resistance_of_3_different_plant_species_and.pdf
S PROFKIGONDUCHRISTINE. "Sekadde-Kigondu C,B and Tantchou J.Laboratory support for Maternal Health in Africa . Chapter 12, pages 169-196, 1994 in a book Contemporary issues in Maternal Health Care in Africa.1994, Edited by JKG Mati, J.M. Kasonde and B. Nasah.". In: Chapter 12, pages 169-196, 1994 in a book Contemporary issues in Maternal Health Care in Africa.1994, Edited by JKG Mati, J.M. Kasonde and B. Nasah. uon press; 1994. Abstract
Normal postpartum women, who had a spontaneous vaginal delivery of one full-term male infant, free of congenital abnormalities and other diseases, were recruited for this study. Thirteen women received 150 mg depot-medroxy-progesterone acetate (DMPA), intramuscularly on days 42 + 1 and 126 + 1 postpartum. Infants of nine mothers, who did not receive DMPA, served as controls. Blood samples were collected from treated mothers on days 44, 47, 74, 124, 128, and 130 postpartum for medroxyprogesterone acetate (MPA) measurements. Four-hour urine collections were obtained from all 22 infants in the morning on days 38, 40, 42, 44, 46, 53, 60, 67, 74, 88, 102, 116, 122, 124, 126, 128, 130, and 137. Urinary follicle stimulating hormone (FSH), luteinizing hormone (LH), unconjugated testosterone, and unconjugated cortisol were measured by radioimmunoassay, and serum MPA and urinary MPA metabolites were measured by gas chromatography-mass spectrometry (GC-MS). No MPA metabolites could be detected in the urine of the infants from the DMPA-receiving mothers. Hormonal profiles in the urine samples were not suppressed in comparison with those of the control infants. The present study demonstrates that DMPA, administered to the mother, does not influence the hormonal regulation of the breast-fed normal male infant.
S PROFOLIECHJOSEPH. "Primary Hyperparathytodism at KNH Assoc. of Surgeons of E.A. proceedings Dec. 1985.". In: Assoc. of Surgeons of E.A. proceedings Dec. 1985. PROF.J.S.OLIECH; 1985. Abstract
No abstract available yet
S PROFKIGONDUCHRISTINE. "Mati J.K.G., et al , Sekadde-Kigondu C.B. Clinical aspects of infertility in Kenya A comprehensive evaluation of the couple J. Obstet. Gynaecol. E. and Central Afr. 6 (2), 61, 1987.". In: East Afr Med J. 1994 Aug;71(8):536-42. uon press; 1987. Abstract
Kenya Medical Research Institute, Clinical Research Centre, Nairobi. Twenty nine patients with rickets were studied in a one year period. The majority of patients (17/29) were below 2 years of age. Most of them had nutritional rickets resulting from a combination of factors. Premature delivery, nonexposure to sunlight, nutritional marasmus and inappropriate dietary intake. Some had familial hypophosphataemic rickets, others had renal tubular acidosis while the rest had rickets with a familial tendency. Both the previous hospital records and the present study indicate that rickets is a persistent problem in children in the community and should be suspected in children who present with features of failure to thrive, among other conditions.
S PROFKIGONDUCHRISTINE. "Marchesini S., Sekadde-Kigondu C.B., Goi G.,Lombardo A. Plasma lysosomal hydrolase in normal malaria parasitized and sickle cell subjects. A study of a sample of Liberian population J. Res. Lab. Med x 5 493-497, 1983.". In: J. Res. Lab. Med x 5 493-497, 1983. uon press; 1983. Abstract
PIP: Menstrual blood loss (MBL) was evaluated in 74 nulliporous Kenyan women aged between 20 and 27 years. The hemoglobin levels were all in normal range with the mean of 13.65 +or- 0.8, 13.84 +or- 1.2 and 13.04 +or- 1.2 g/100 ml respectively in 3 populations. The MBL was comparable in the 3 populations with the mean of 35.1 +or- 12.6, 30.6 +or- 8.7 and 32.2 +or- 9.4 ml respectively. There was no difference of statistical significance between the 2 periods studied per each individual. This study objectively assesses the menstrual blood loss in 3 population groups–2 urban and 1 rural. The data can be used to evaluate menstrual blood loss before and after initiation of various contraceptives used in Kenya. Subjects were volunteers who were not on any contraception except barrier or natural rhythm methods, not under psychological stress and who exhibited normal physical female characteristics on examination. Those who wished to drop out, became pregnant or desired contraception, were excluded. The study confirms the individual constancy of the menstrual blood loss in this population. This has important practical implications since a single determination of the menstrual blood loss may be a fairly good expression for the average blood loss in a woman. The immediate effect of various treatments such as IUD insertion or oral contraceptives on the MBL may easily be evaluated quantitatively by measurements in consecutive periods using only 1 period as a control. The quick method can be easily used in evaluating pathological conditions e.g. iron-deficiency due to heavy bleeding, IUD-associated hemorrhage, menorrhagia and uterine fibroid.
S PROFIGONSANGWASHIBAIRO. "The effects of gibberellic acid (GA3) on sprouting and quality of potato seed tubers in diffused light and pit storage conditions. Journal of Biological Sciences, 6 (4): 723-733.". In: Journal of Plant Nutrition. Taylor & Francis; 2006. Abstract
Normal 0 false false false MicrosoftInternetExplorer4 st1:*{behavior:url(#ieooui) } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} Hepatocellular carcinoma results when cancerous cells are localized in the liver. It is distributed globally with high prevalence in sub-Saharan African, southern Asia, China and Japan. Diagnosis is experimental and in many cases inaccurate due to unreliability of markers. Prognosis is poor and the cost of treatment prohibitive. Conventional radiation and chemotherapy lead to loss of hair, fertility and general weakening of the body`s immune system increasing a patient`s risk to infection. These observations underscore the need for improved, or additional methods of cancer diagnosis and management. We investigated the effect of polysaccharide rich Pleurotus pulmonarius fruit body extracts on progression of chemically induced hepatocellular carcinoma in CBA mice. Addition of Pleurotus pulmonarius extracts in diet delayed progression of carcinogenesis suggesting   that these extracts may be useful as   adjuvants to conventional cancer therapies.   Key words: carcinogenesis; mice; mushroom extracts; pleurotus pulmunarius   Corresponding author: Ms Carolyne Wasonga, Department of Biochemistry, University of Nairobi, P.O. Box 30197, Nairobi,  Kenya. E-mail: carox27@yahoo.ca     Charles O.A. Omwandho, Susanne E. Gruessner, John Falconer, Hans-R Tinneberg, Timothy K. Roberts. IS OVINE PLACENTAL IGG TOXIC TO HUMAN PERIPHERAL BLOOD NATURAL KILLER CELLS?
S EDWARDS, G GC. ". Highly sensitive antigen detection Procedures for the diagnosis of Infectious Bovine Rhinotracheitis: Amplified Elisa and Reverse passive Haemaglutination. ." Veterinary Microbiology. 1987;13:135-141. Abstractpub_40_edwards_and_gitao_1987.pdfWebsite

The stability of adrenaline ophthalmic solutions, at pH 5.8 and 7.4, to sterilization and storage conditions has been studied. Solutions sterilized by filtration or heating at 98 degrees C for 30 min showed no detectable degradation at either pH value, whilst sterilization at higher temperatures resulted in losses of up to 30%. Total degradation increased with increasing sterilization temperature at both pH values.

S PROFIGONSANGWASHIBAIRO. "Weed control in cole crops and onion (Allium cepa) using ammonium nitrate. Weed Science, 44: 952-958.". In: Paper submitted in the 3rd International Weed Science Congress in June 2000 at Foz du Iguasu, Brazil. Taylor & Francis; 1996. Abstract
Normal 0 false false false MicrosoftInternetExplorer4 st1:*{behavior:url(#ieooui) } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} Hepatocellular carcinoma results when cancerous cells are localized in the liver. It is distributed globally with high prevalence in sub-Saharan African, southern Asia, China and Japan. Diagnosis is experimental and in many cases inaccurate due to unreliability of markers. Prognosis is poor and the cost of treatment prohibitive. Conventional radiation and chemotherapy lead to loss of hair, fertility and general weakening of the body`s immune system increasing a patient`s risk to infection. These observations underscore the need for improved, or additional methods of cancer diagnosis and management. We investigated the effect of polysaccharide rich Pleurotus pulmonarius fruit body extracts on progression of chemically induced hepatocellular carcinoma in CBA mice. Addition of Pleurotus pulmonarius extracts in diet delayed progression of carcinogenesis suggesting   that these extracts may be useful as   adjuvants to conventional cancer therapies.   Key words: carcinogenesis; mice; mushroom extracts; pleurotus pulmunarius   Corresponding author: Ms Carolyne Wasonga, Department of Biochemistry, University of Nairobi, P.O. Box 30197, Nairobi,  Kenya. E-mail: carox27@yahoo.ca     Charles O.A. Omwandho, Susanne E. Gruessner, John Falconer, Hans-R Tinneberg, Timothy K. Roberts. IS OVINE PLACENTAL IGG TOXIC TO HUMAN PERIPHERAL BLOOD NATURAL KILLER CELLS?
S PROFKIGONDUCHRISTINE. "Millennium development goal 5: a review of maternal mortality at the Kenyatta National Hospital, Nairobi. East Afr Med J. 2006 Jan;83(1):4-9.". In: East Afr Med J. 2006 Jan;83(1):4-9. uon press; 2006. Abstract
OBJECTIVES: To review if there is a change in the maternal mortality rate at the Kenyatta National Hospital since the inception of the Millennium Development Goal strategy in 1990, compared to earlier reviews. DESIGN: A retrospective descriptive study. SETTING: Kenyatta National Hospital. SUBJECTS: Maternal deaths attributed directly to obstetric causes. MAIN OUTCOME MEASURES: Determination of maternal mortality rates of all patients admitted to the Kenyatta National Hospital Maternity and died after admission up till six weeks of admission. Also determine any avoidable causes of the same. RESULTS: During the period under review, there were 27,455 deliveries and 253 maternal deaths giving a maternal mortality ratio of 921.5 per 100,000 live births. Direct obstetric causes accounted for 71% of all maternal deaths with sepsis, haemorrhage, and hypertension being the leading causes. Respiratory tract infections associated with HIV/ AIDS infection was the prominent indirect cause. 67.5% of deaths occurred in women aged between 25 and 35 years and 78.7% were Para 2 or less. Evidently there was poor antenatal clinic attendance with only 28.6% having had any attendance at all. CONCLUSION: Antenatal clinic attendance needs to be re-emphasised if an impact is to be realised in curbing maternal mortality; moreover there is need for early referrals and encouraging mothers to deliver under skilled care.
S PROFKIGONDUCHRISTINE. "Kokonya DA, Sinei SK, Sekadde-Kigondu CB, Morrison CS, Kwok C, Weiner DH. Experience with IUCD insertion outside of menses in Kenya. East Afr Med J. 2000 Jul;77(7):369-73.". In: Int. J. of STDs and AIDS 11 257, 2000. uon press; 2000. Abstract
OBJECTIVE: To determine if women receiving intrauterine devices (IUCDs) outside of menses have an acceptable rate of insertion problems and subsequent IUCD-related complications. DESIGN: Cross-sectional and prospective cohort study of insertions at times other than during menses. SETTING: The study was carried out in two government family planning (FP) clinics in Nairobi, Kenya. SUBJECTS: After appropriate pre-test and post-test HIV counselling, 1686 women requesting IUCDs at two FP clinics between 1994 and 1995 in Nairobi were enrolled at baseline into a study examining the effect of human immuno-deficiency virus (HIV) infection on IUCD-related complications. Six hundred and forty nine women (156 HIV-infected and 493 HIV-uninfected) were selected for the four month follow up study. They were classified according to their menstrual cycle status at time of IUCD insertion. MAIN OUTCOME MEASURES: Problems at the time of insertion (pain, bleeding, immediate expulsion) and IUCD-related complications through four months. RESULTS: Rates of immediate insertion problems were low in the women who had insertions during menses (7.0%), outside of menses (4.0%) or had oligomenorrhea/amenorrhea (2.6%). The adjusted odds ratios for IUCD insertion problems outside of menses and in oligomenorrhea/amenorrhea (versus women with insertion during menses) were 0.54 (95 % CI 0.18-1.59) and 0.39 (95% CI 0.12-1.29) respectively. IUCD-related complications were higher in the oligomenorrhea/amenorrhea (11.5%) or insertion outside of menses (6.9%), than the within menses (4.3%) groups. However, the differences were not statistically significant. Adjusted odds ratios for IUCD outside of menses and oligomenorrhoea/amenorrhea groups were 1.65 (95% CI 0.21-12.91) and 2.72 (95% CI 0.34-21.71) respectively. CONCLUSION: The results confirm that the IUCD can be safely inserted outside of menses with minimal insertion difficulties and subsequent complications. Availability of IUCDs outside of menses may enhance IUCD acceptance in Kenya and create better opportunity for visual screening of the cervix for sexually transmitted infections.
S PROFMASINDEMICHAEL. "Munene, R. M., Adala, H. S., Masinde, M. S., Rana, F. S. Vitamin A deficiency among Kenya children as detected by conjunctival impression cytology. E. African Medical Journal. 80: 476, 2003.". In: E. African Medical Journal. 80: 476, 2003.; 2003. Abstract
OBJECTIVE: To determine the prevalence of Xerophthalmia among Kenyan children aged four to seven years in high risk using Conjuctival Impression Cytology and transfer. DESIGN: A cross sectional community based study. SETTING: Mathare slum in Nairobi and Tiva/Ithiani area of Kitui. SUBJECTS: Children aged four to seven years residing in the above areas were assessed for both clinical and cytological features of vitamin A deficiency. RESULTS: Of the 342 children included in this study, 316 (92.0%) were normal, five (1.5%) had XN, 19 (5.9% had XIA and two (0.6%) had XIB. No signs of corneal Xerophthalmia were seen in this study. Conjuctival impression cytology and transfer (CICT) was used to asses for squamous metaplastic changes associated with Vitamin A deficiency (VAD). Seventy five (23.1%) of the children were normal by CICT while 249 (76.9%) were abnormal. In comparing the two areas of study, only 13.2% of the children in Mathare had normal CICT compared to 50% in Kitui. For each of the age groups studied there was significant difference between the two areas with children from Mathare being more deficient than those from Kitui. CONCLUSION: VAD is a significant health problem in the high risk areas assessed by CICT in this study.
S S, C S-K, er CS G, W W. "Prevalence of Cytotoxin-associated gene A (CagA) positive Helicopter pylori strains in asymptomatic H. pylori-infected children attending Kenyatta National Hospital, Nairobi and correlation with risk factors associated with infection acquisition." East African Journal of Pathology. 2015;2(1):2-7. Abstractprevalence_of_cytotoxin-associated_gene_a_caga_positive_helicobacter_pylori_strains_in_asymptomatic_h._pylori-infected_children_attending_kenyatta_national_hospital_nairobi_and_correlatio.pdf

Background: Helicobacter pylori bacteria colonize the gastric mucosa of 20-80% of humans worldwide. Approximately 60-70% of H. pylori strains possess the Cytotoxinassociated gene A (CagA gene) and express the CagA protein, an oncoprotein and a highly immunogenic virulence factor that has been linked to gastric disease.
Objective: To determine the prevalence ofCagA positive H.pylori among asymptomatic children attending Kenyatta National Hospital (KNH), Nairobi.
Design: Cross-sectional descriptive study at KNH paediatric outpatient clinic and paediatric wards and at the immunology laboratory, University of Nairobi.
Subjects: Children aged 2-13 years attending KNH, presenting with non-gastrointestinal tract conditions.
Methods: Socio-demographic information was collected by direct interview of the participants' parents/guardians (respondents) and entered into a study questionnaire. Serum samples from the subjects were tested by ELISA for the anti-H. pylori IgG antibody. Those that tested positive were tested for anti-CagA IgG antibody.
Results: A total of 175 children with a mean age of 7.5 years were enrolled, 57.3 % being males. The overall prevalence of H. pylori was 50.3%. CagA positive H. pylori prevalence among those who tested positive for H. pylori was 64.8%. There was significant positive correlation of H. pylori seropositivity with age (p

S PROFKIGONDUCHRISTINE. "Leslie PW, Campbell KL, Little MA, Kigondu CS. Evaluation of reproductive function in Turkana women with enzyme immunoassays of urinary hormones in the field.Hum Biol. 1996 Feb;68(1):95-117.". In: Hum Biol. 1996 Feb;68(1):95-117. uon press; 1996. Abstract
Department of Anthropology and Carolina Population Center, University of North Carolina, Chapel Hill 27516, USA. The frequently reported observation that nomadic populations have lower fertility than their settled counterparts is often attributed to what are perceived as harsh, stressful conditions under which the nomads live. But the consequences of the hypothesized stresses for the reproductive biology or demography of these populations have been documented only a little. Traditionally, the Turkana of northwest Kenya are nomadic herders, but increasing numbers have settled on agricultural development schemes. We used an array of hormonal assays along with anthropometric indexes of nutritional status and interviews covering reproductive history, recent menstruation, diet, and health to compare reproductive function in nomadic and settled Turkana women. First morning urine samples were collected for three consecutive days during a series of surveys. Human choriogonadotropin (hCG; a marker for pregnancy), luteinizing hormone (LH; an indicator of ovulation), and pregnanediol glucuronide (PdG; an indicator of postovulatory luteal function) were assessed in the field with commercially available dipstick enzyme immunoassays. These assays along with the interview data allowed us to determine the reproductive status (e.g., pregnant or cycling, and if cycling, which phase of the ovarian cycle) of 166 nomadic and 194 settled Turkana women. The cross-sectional classifications allowed inferences of conception rates and normality of ovarian function. Follow-up surveys provided rates of pregnancy loss. Compared with the settled women, the nomadic women exhibited lower pregnancy rates and cycling nomadic women were less likely to show evidence of ovulation or luteal function. These results suggest that reproductive function of the nomadic women is diminished relative to the settled women. However, the settled women experienced a much higher rate of pregnancy loss, which may mean that their effective fecundability is in fact lower than that of the nomadic women. This study is the first to apply such a wide range of hormonal assays in the field. It demonstrates that field-based assays are feasible and robust and can play an important role in epidemiological and biodemographic studies, even in remote locations under conditions that would ordinarily be considered incompatible with on-site laboratory analysis.
S PROFKIGONDUCHRISTINE. "R.K. Kamau, F.W. Maina, C.S. Kigondu, J.K.G. Mati The effects of low-oestrogen pill, progestogen-only pill and medroxyprogestorone acetate on oral glucose tolerance test. E. Afr. Med. J. 67 (8), 550, 1990.". In: E. Afr. Med. J. 67 (8), 550, 1990. uon press; 1990. Abstract

PIP: The effects of the triphasic oral contraceptive (OC) ethinyl estradiol (EE) and levonorgestrel (LNG) on lipid and lipoprotein metabolism were evaluated in 97 black Kenyan women. Subjects were recruited from the Family Planning Clinic and were followed for 12 months. There was an increase in fasting levels of total cholesterol. These changes were not statistically significant. However, the triglyceride increase was statistically significant at 9 months and 12 months (p0.05). The high density cholesterol remained unchanged. Thus, this triphasic OC was found to have minimal effect on lipid and lipoprotein metabolism. author's modified

S PROFOLIECHJOSEPH. "Intravenous Feeding in General Surgery. E.A. Med. J. Vol. 54 No. 1, 1977.". In: E.A. Med. J. Vol. 54 No. 1, 1977. PROF.J.S.OLIECH; 1977. Abstract
No abstract yet.
S PROFKIGONDUCHRISTINE. "Wanjohi J.K., Sekadde-Kigondu C.B., Maina F.W. Mati J.K.G., J. Obstet. Gynaecol. E. Central Afr. 2:23, 1983 Menstrual blood loss in nulliparous normal women.". In: J Obstet Gynaecol East Cent Africa. 1983 Mar;2(1):23-6. uon press; 1983. Abstract
PIP: Menstrual blood loss (MBL) was evaluated in 74 nulliporous Kenyan women aged between 20 and 27 years. The hemoglobin levels were all in normal range with the mean of 13.65 +or- 0.8, 13.84 +or- 1.2 and 13.04 +or- 1.2 g/100 ml respectively in 3 populations. The MBL was comparable in the 3 populations with the mean of 35.1 +or- 12.6, 30.6 +or- 8.7 and 32.2 +or- 9.4 ml respectively. There was no difference of statistical significance between the 2 periods studied per each individual. This study objectively assesses the menstrual blood loss in 3 population groups–2 urban and 1 rural. The data can be used to evaluate menstrual blood loss before and after initiation of various contraceptives used in Kenya. Subjects were volunteers who were not on any contraception except barrier or natural rhythm methods, not under psychological stress and who exhibited normal physical female characteristics on examination. Those who wished to drop out, became pregnant or desired contraception, were excluded. The study confirms the individual constancy of the menstrual blood loss in this population. This has important practical implications since a single determination of the menstrual blood loss may be a fairly good expression for the average blood loss in a woman. The immediate effect of various treatments such as IUD insertion or oral contraceptives on the MBL may easily be evaluated quantitatively by measurements in consecutive periods using only 1 period as a control. The quick method can be easily used in evaluating pathological conditions e.g. iron-deficiency due to heavy bleeding, IUD-associated hemorrhage, menorrhagia and uterine fibroid.
S PROFKIGONDUCHRISTINE. "Papine J., Lutalo-Bosa A.J., Sekadde C.B. Reported in the Annual Report of Scientific Conference of the East African Medical Research Council, 1977. The Effect of Halothane on the levels of serum proteins.". In: Annual Report of Scientific Conference of the East African Medical Research Council. uon press; 1977. Abstract

PIP: Masturbatory semen specimen from 49 fertile Black African males in Kenya whose wives were pregnant was obtained after at least 3 days of abstinence for the analysis of parameters which included volume motility, vitality, sperm concentration, pH, fructose and acid phosphatase levels. About 1/2 the spermatozoa was actively progressive in motility, while 40% was nonmotile. Vitality in the 1st hour revealed that 81.4% of the sperm was alive. About 90% of the semen specimens had more than 40% idea forms of spermatozoa. Spermatozoal abnormalities were a frequent feature. There was no correlation between age and the testicular volume, but seminal fluid volume and sperm density tended to decrease with age. Serum levels of Follicle Stimulating Hormone, Luteinizing Hormone, Prolactin and Testosterone were determined in the subjects' sera, enabling the establishment of reference values for these parameters in African Kenyan males.

S MRWANYAMAJOSEPH. SEIZING THE NIGHT. Nairobi: Blue Hills; 2006.Website
S PROFIGONSANGWASHIBAIRO. "Replacement of postharvest moisture loss by recharging and its effect on subsequent moisture loss during short term storage of carrot (Daucus carota L.). Journal of American Society for Horticultural. Science, 123 (1): 141-145.". In: Paper submitted in the 3rd International Weed Science Congress in June 2000 at Foz du Iguasu, Brazil. Taylor & Francis; 1998. Abstract
Normal 0 false false false MicrosoftInternetExplorer4 st1:*{behavior:url(#ieooui) } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} Hepatocellular carcinoma results when cancerous cells are localized in the liver. It is distributed globally with high prevalence in sub-Saharan African, southern Asia, China and Japan. Diagnosis is experimental and in many cases inaccurate due to unreliability of markers. Prognosis is poor and the cost of treatment prohibitive. Conventional radiation and chemotherapy lead to loss of hair, fertility and general weakening of the body`s immune system increasing a patient`s risk to infection. These observations underscore the need for improved, or additional methods of cancer diagnosis and management. We investigated the effect of polysaccharide rich Pleurotus pulmonarius fruit body extracts on progression of chemically induced hepatocellular carcinoma in CBA mice. Addition of Pleurotus pulmonarius extracts in diet delayed progression of carcinogenesis suggesting   that these extracts may be useful as   adjuvants to conventional cancer therapies.   Key words: carcinogenesis; mice; mushroom extracts; pleurotus pulmunarius   Corresponding author: Ms Carolyne Wasonga, Department of Biochemistry, University of Nairobi, P.O. Box 30197, Nairobi,  Kenya. E-mail: carox27@yahoo.ca     Charles O.A. Omwandho, Susanne E. Gruessner, John Falconer, Hans-R Tinneberg, Timothy K. Roberts. IS OVINE PLACENTAL IGG TOXIC TO HUMAN PERIPHERAL BLOOD NATURAL KILLER CELLS?
S PROFKIGONDUCHRISTINE. "101. Wango, E.O, Tabifor, H.N, Muchiri, L.W., Sekadde-Kigondu, C. Progesterone, Estradiol and their receptors in leiomyomata and the adjacent normal myometria of black Kenyan women .Afr. J.Health Sci. 9:123, 2002.". In: E.A.M.J vol 79 (10) 530, 2002. uon press; 2002. Abstract
Reproductive Biology Unit, Department of Animal Physiology, University of Nairobi, Kenya. dochiel@kisian.mimcom.net The presence of human immunodeficiency virus (HIV) in genital secretions is regarded as a risk factor for sexual and perinatal transmission of HIV. A better understanding of correlates of genital shedding of HIV is crucial to the development of effective strategies against transmission of this virus. Events during menstrual cycle are likely to influence local immune responses and viral load in genital secretions, and hence determine susceptibility to HIV or efficiency of virus transmission. We report, in this study, preliminary findings on the relationship of menstrual cycle to genital mucosal and systemic immunity in female olive baboons (Papio anubis) experimentally inoculated with simian/human immunodeficiency virus (SHIV)89.6P.
S PROFKIGONDUCHRISTINE. "Sinei, S.K., Fortney, J.A., Sekadde-Kigondu, C.B., et al, Contraceptive Use and HIV Infection in Kenya Family Planning Clinics Attendants. International J. of STD and AIDS Vol. 7, 65-70, 1996.". In: International J. of STD and AIDS Vol. 7, 65-70, 1996. uon press; 1996. Abstract
This pilot study aimed to determine the feasibility of a larger study of contraception and risk of HIV infection in women. We also measured risk factors for and occurrence of HIV infection in the participants. A cohort of 1537 seronegative women attending a family planning clinic in Nairobi, Kenya was enrolled and followed for up to 12 months per woman. HIV testing was done quarterly. A nested case-control analysis was done with seroconverting women (cases) and 3 matched controls per case, who had detailed interviews and received physical examinations and STD tests. The prevalence of HIV at enrollment was 6.1%; seropositive women were excluded from further analysis. The 12-month life-table cumulative incidence of HIV was 2.1 per 100 women (95% confidence interval [CI] 1.1-3.2). In the nested case-control analysis (17 cases and 51 controls), the crude odds ratio of HIV infection comparing oral contraceptive (OC) users with other women was 3.5 (95%) CI 0.8-21.5), which persisted after control for single confounders at a time. The putative association between OC use sand HIV infection is critical to public health policy, yet no study has been conducted specifically to measure it, yielding weak and conflicting evidence. We intend to conduct a larger study with a similar design as the current pilot study, which confirmed the feasibility of a more definitive project.
S DRKARANJAHDOMINIC. "Karanja D.S .". In: The Limnology, Climatology and Palaeoclimatology of the East African Lakes pp. 413-431, Gordon and Breach Publishers, Amsterdam. June 1996 b) Books Reference Date. Earthscan, London. 978-1-84407-469-3 (*); 1982. Abstract
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S PROFKIGONDUCHRISTINE. "Sekadde- Kigondu C.B. The role of Women in Biomedical Research in Kenya. Proceedings of the conference by the Canadian International Development Agency and the Third World Academy of Sciences , Published by World Scientific Editors, A.M Faruqui, M.H.A. Ha.". In: A.M Faruqui, M.H.A. Hassan and G. Sandri, page 279, 1991. uon press; 1991. Abstract
Forty females, age 14 to 35 years (mean 28.6 years) with chronic renal failure (CRF) were included in the study. Their menstrual patterns were noted. The function of their hypothalamo-pituitary-ovarian axis was assessed by the serum levels of follicle stimulating hormone (FSH), Luteinising hormone (LH), prolactin (PrL), estradiol (E2) and progesterone (P) at different phases of the menstrual cycle in patients who continued to have normal menses (Group 1) and at weekly intervals for six weeks in patients with menstrual disturbances (Group II). The mean hormone levels during the initial contact Luteal phase in group I were FSH 12.0 IU/L (N, 1.0-3.0 IU/L), LH 1.8IU/L (N 1.5-101U/L), PrL 652mIU/L (N, 100-600 mIU/L) mE2 160 pmol/L (N 400-1400 pmol/L) and P5 nmol/L (N 14-60 nmol/L) for group I. Corresponding values for group II were 1.2, 10.3, 250, 600 and 3.0 in relevant units. All patients (fourteen) with end stage renal disease (ESRD) had amenorrhoae. On the other hand, most patients with stable CRF (22/26) had normal menses. Following initiation of therapy (conservative or dialytic), there was no significant alteration in the hormonal profile or menstrual pattern. We conclude that other factors apart from the hormonal imbalances, may be responsible for the menstrual disturbances noted in patients with CRF.
S PROFOLIECHJOSEPH. "Case report of pyogenic thyroiditis at Kenyatta National Hospital.". In: East Afr Med J. 1979 Jan;56(1):40-1. PROF.J.S.OLIECH; 1979. Abstract
No abstract available yet.
S PROFMASINDEMICHAEL, R. DRILAKODUNERA. "D.R. Ilako, M. Bhaiji, M.S. Masinde Immunoglobulin Levels in Tears M.Med Thesis 1991.". In: M.Med Thesis 1991. Philosophical Issues Invoked by Shona People; 1991. Abstract

OBJECTIVES: To estimate the prevalence of active trachoma (TF) in children aged one to nine years and potentially blinding trachoma (TT) in adults aged 15 years and older in six known trachoma-endemic districts in Kenya. DESIGN: Community based survey. SETTING: Six known trachoma endemic districts in Kenya (Samburu, Narok, West Pokot, Kajiado Baringo and Meru North). SUBJECTS: A total of 6,982 children aged one to nine years and 8,045 adults aged 15 years and older were randomly selected in a two stage random cluster sampling method: Twenty sub-locations (clusters) per district and three villages per sub-location were randomly selected. Eligible children and adults were enumerated and examined for signs of trachoma. RESULTS: Blinding trachoma was found to be a public health problem in all the surveyed districts. Active trachoma was a district wide public health problem in four districts (Samburu, Narok, West Pokot and Kajiado) and only in some of the sub-locations of the other two (Baringo and Meru North). CONCLUSIONS: There is need for district trachoma control programmes preferably using the WHO recommended SAFE strategy in all the surveyed districts. Extrapolation of these survey results to the entire country could not be justified. There is need to survey the remaining 12 suspected endemic districts in Kenya.

S PROFKIGONDUCHRISTINE. "Ojwang P.J., OgadaT., Maina F.W., Sekadde_Kigondu C.B , Mati J.K.G. E.A. Med. J. 61 (5): 367, 1984. Reference value for serum lipids and lipoprotein cholesterol in adults and cord blood of Kenyan Africans.". In: E.A. Med. J. 61 (5): 367, 1984. uon press; 1984. Abstract

PIP: 125 black Kenyan women attending the Kenyatta National Family Welfare Clinic were randomly allocated to combined and fixed dose oral contraceptives (Eugynon: 500 mcg dl-norgestrel + 50 mcg ethinyl estradiol or Microgynon: 150 mcg levonorgestel + 30 mcg ethinyl estradiol). They were between 18-33 years of age with a mean of 25 +or- 7 years. The mean parity of this group was 3 and they had a mean education standard of 8 years. Fasting blood sampled were taken on recruitment (control cycle) and thereafter once for cycles 1, 3, 6, 9, and 12 during OC use. HDL-cholesterol was estimated in the sear. The 2 OCs elicited a significant decrease in levels of HDL-cholesterol (p0.01). author's modified

S PROFKIGONDUCHRISTINE. "Karanja JG, Gwanyi-chore MO, Sekadde-kigondu CB, Lequin RM, Mati JK. Hormonal patterns during the menstrual cycles in healthy black Kenyan women. J Obstet Gynaecol East Cent Africa. 1982 Dec;1(4):140-4.". In: J. Obs/Gyn. East Central Africa 1:126(1982). uon press; 1982. Abstract
PIP: 17 regularly mentruating young black Kenyan women were studied during a mentrual cylcle for their reproductive hormonal patterns. The serum concentrations of Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH) and Prolactin (PRL) were determined by World Health Organization Matched Reagent Programme Radioimmunoassay (WHO-MR-RIA). A biphasic basal body temperature (BBT) record was also noted. The hormonal patterns showed a mid-cycle LH surge and rise in plasma progesterone beginning with the LH peak and lasting a maximum of 6-8 days after the LH peak. Cycle lengths ranged from 25-32 days with a mean of 28 plus or minus 2 days. The follicular phase ranged from 10-17 days, and the luteal phase lasted from 13-15 days. When the mean LH and FSH concentrations and the mean BBT curve were synchronized on the day of the mid-cycle LH peak, the temperature elevation occured about 48 days after the LH peak. Along with the LH, the FSH showed a mid-cycle peak. The results of this study
S PROFIGONSANGWASHIBAIRO. "Effects of accel (Gibberellins (GA4+7) + Benzyladenine) on postharvest shelf life of French beans (Phaseolus vulgaris L.).". In: African Crop Science Proceedings 6: 536-540. Taylor & Francis; 2003. Abstract
Normal 0 false false false MicrosoftInternetExplorer4 st1:*{behavior:url(#ieooui) } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} Hepatocellular carcinoma results when cancerous cells are localized in the liver. It is distributed globally with high prevalence in sub-Saharan African, southern Asia, China and Japan. Diagnosis is experimental and in many cases inaccurate due to unreliability of markers. Prognosis is poor and the cost of treatment prohibitive. Conventional radiation and chemotherapy lead to loss of hair, fertility and general weakening of the body`s immune system increasing a patient`s risk to infection. These observations underscore the need for improved, or additional methods of cancer diagnosis and management. We investigated the effect of polysaccharide rich Pleurotus pulmonarius fruit body extracts on progression of chemically induced hepatocellular carcinoma in CBA mice. Addition of Pleurotus pulmonarius extracts in diet delayed progression of carcinogenesis suggesting   that these extracts may be useful as   adjuvants to conventional cancer therapies.   Key words: carcinogenesis; mice; mushroom extracts; pleurotus pulmunarius   Corresponding author: Ms Carolyne Wasonga, Department of Biochemistry, University of Nairobi, P.O. Box 30197, Nairobi,  Kenya. E-mail: carox27@yahoo.ca     Charles O.A. Omwandho, Susanne E. Gruessner, John Falconer, Hans-R Tinneberg, Timothy K. Roberts. IS OVINE PLACENTAL IGG TOXIC TO HUMAN PERIPHERAL BLOOD NATURAL KILLER CELLS?
S PROFKIGONDUCHRISTINE. "Ndavi,PM, Kyobe.j, Munyao,G., OyiekeBO, Sekadde-Kiogndu, CB. Coagulation studies in Hypertensive Disease of pregnancy.J.Obs Gyn, Centr. Africa. 16(2003),.". In: J.Obs Gyn, Centr. Africa. 16(2003),. uon press; 2003. Abstract
The presence of human immunodeficiency virus (HIV) in genital secretions is regarded as a risk factor for sexual and perinatal transmission of HIV. A better understanding of correlates of genital shedding of HIV is crucial to the development of effective strategies against transmission of this virus. Events during menstrual cycle are likely to influence local immune responses and viral load in genital secretions, and hence determine susceptibility to HIV or efficiency of virus transmission. We report, in this study, preliminary findings on the relationship of menstrual cycle to genital mucosal and systemic immunity in female olive baboons (Papio anubis) experimentally inoculated with simian/human immunodeficiency virus (SHIV)89.6P.
S PROFKIGONDUCHRISTINE. "Sekadde-Kigondu,C.B., Kirumbi, L.W., Njoroge, J.W., Njoroge, J.K., et al. The Prevalence of Hyperprolactinemia in Infertile Women in a Rural Area in Kenya. J. Obstet. Gynaecol. E. and Centr. Afr. 13;21, 1997.". In: E.A.Med. J. 74: 561,1997. uon press; 1997. Abstract
Aga Khan Hospital, Nairobi. Forty females, age 14 to 35 years (mean 28.6 years) with chronic renal failure (CRF) were included in the study. Their menstrual patterns were noted. The function of their hypothalamo-pituitary-ovarian axis was assessed by the serum levels of follicle stimulating hormone (FSH), Luteinising hormone (LH), prolactin (PrL), estradiol (E2) and progesterone (P) at different phases of the menstrual cycle in patients who continued to have normal menses (Group 1) and at weekly intervals for six weeks in patients with menstrual disturbances (Group II). The mean hormone levels during the initial contact Luteal phase in group I were FSH 12.0 IU/L (N, 1.0-3.0 IU/L), LH 1.8IU/L (N 1.5-101U/L), PrL 652mIU/L (N, 100-600 mIU/L) mE2 160 pmol/L (N 400-1400 pmol/L) and P5 nmol/L (N 14-60 nmol/L) for group I. Corresponding values for group II were 1.2, 10.3, 250, 600 and 3.0 in relevant units. All patients (fourteen) with end stage renal disease (ESRD) had amenorrhoae. On the other hand, most patients with stable CRF (22/26) had normal menses. Following initiation of therapy (conservative or dialytic), there was no significant alteration in the hormonal profile or menstrual pattern. We conclude that other factors apart from the hormonal imbalances, may be responsible for the menstrual disturbances noted in patients with CRF.
S PROFMASINDEMICHAEL. "Masinde, M. S. Hyphema study at Kenyatta National Hospital East. African Journal of Ophthalmology 6: 32 .". In: African Journal of Ophthalmology 6: 32 .; 1982. Abstract
OBJECTIVE: To determine the prevalence of Xerophthalmia among Kenyan children aged four to seven years in high risk using Conjuctival Impression Cytology and transfer. DESIGN: A cross sectional community based study. SETTING: Mathare slum in Nairobi and Tiva/Ithiani area of Kitui. SUBJECTS: Children aged four to seven years residing in the above areas were assessed for both clinical and cytological features of vitamin A deficiency. RESULTS: Of the 342 children included in this study, 316 (92.0%) were normal, five (1.5%) had XN, 19 (5.9% had XIA and two (0.6%) had XIB. No signs of corneal Xerophthalmia were seen in this study. Conjuctival impression cytology and transfer (CICT) was used to asses for squamous metaplastic changes associated with Vitamin A deficiency (VAD). Seventy five (23.1%) of the children were normal by CICT while 249 (76.9%) were abnormal. In comparing the two areas of study, only 13.2% of the children in Mathare had normal CICT compared to 50% in Kitui. For each of the age groups studied there was significant difference between the two areas with children from Mathare being more deficient than those from Kitui. CONCLUSION: VAD is a significant health problem in the high risk areas assessed by CICT in this study.
S DRKARANJAHDOMINIC. "Karanja D.S and Gichuru M. Report of the Pharmaceutical Services Review Committee .". In: The Limnology, Climatology and Palaeoclimatology of the East African Lakes pp. 413-431, Gordon and Breach Publishers, Amsterdam. June 1996 b) Books Reference Date. Earthscan, London. 978-1-84407-469-3 (*); 1986. Abstract
n/a
S PROFKIGONDUCHRISTINE. "J.J. Bwayo, A.M. Omari, A.N. Mutere, W.Jaoko, C. Sekadde-Kigondu, J. Kreiss, F.A. Plummer. Long distance drivers: Prevalence of sexually transmitted disease. E.A. Med. J. 68 (6) 425, 1991.". In: E.A. Med. J. 68 (6) 425, 1991. uon press; 1991. Abstract
Forty females, age 14 to 35 years (mean 28.6 years) with chronic renal failure (CRF) were included in the study. Their menstrual patterns were noted. The function of their hypothalamo-pituitary-ovarian axis was assessed by the serum levels of follicle stimulating hormone (FSH), Luteinising hormone (LH), prolactin (PrL), estradiol (E2) and progesterone (P) at different phases of the menstrual cycle in patients who continued to have normal menses (Group 1) and at weekly intervals for six weeks in patients with menstrual disturbances (Group II). The mean hormone levels during the initial contact Luteal phase in group I were FSH 12.0 IU/L (N, 1.0-3.0 IU/L), LH 1.8IU/L (N 1.5-101U/L), PrL 652mIU/L (N, 100-600 mIU/L) mE2 160 pmol/L (N 400-1400 pmol/L) and P5 nmol/L (N 14-60 nmol/L) for group I. Corresponding values for group II were 1.2, 10.3, 250, 600 and 3.0 in relevant units. All patients (fourteen) with end stage renal disease (ESRD) had amenorrhoae. On the other hand, most patients with stable CRF (22/26) had normal menses. Following initiation of therapy (conservative or dialytic), there was no significant alteration in the hormonal profile or menstrual pattern. We conclude that other factors apart from the hormonal imbalances, may be responsible for the menstrual disturbances noted in patients with CRF.
S PROFOLIECHJOSEPH. "Training of a surgeon (Editorial) Medicom Vol. 2:25, 1980.". In: Medicom Vol. 2:25, 1980. PROF.J.S.OLIECH; 1980. Abstract
No abstract yet
S PROFKIGONDUCHRISTINE. "Rogo K.O., Sekadde-Kigondu C.B., Ojwang P.J., Mati J.K.G., Njoroge J.K. The effects of Tropical conditions on male fertility indices. J. Obstet. Gynaecol. E. and Central Afr. 4:45, 1985.". In: J. Obstet. Gynaecol. E. and Central Afr. 4:45, 1985. uon press; 1985. Abstract

PIP: 125 black Kenyan women attending the Kenyatta National Family Welfare Clinic were randomly allocated to combined and fixed dose oral contraceptives (Eugynon: 500 mcg dl-norgestrel + 50 mcg ethinyl estradiol or Microgynon: 150 mcg levonorgestel + 30 mcg ethinyl estradiol). They were between 18-33 years of age with a mean of 25 +or- 7 years. The mean parity of this group was 3 and they had a mean education standard of 8 years. Fasting blood sampled were taken on recruitment (control cycle) and thereafter once for cycles 1, 3, 6, 9, and 12 during OC use. HDL-cholesterol was estimated in the sear. The 2 OCs elicited a significant decrease in levels of HDL-cholesterol (p0.01). author's modified

S PROFKIGONDUCHRISTINE. "Ndeto G.W.T., Mati J.K.G., Sekadde-Kigondu C.B., Lequin R.M. Prolactin response in patients with hypertensive disease in pregnancy J. Obstet. Gynaecol. E. Central Afr. 1:166, 1982.". In: J. Obstet. Gynaecol. E. Central Afr. 1:166, 1982. uon press; 1982. Abstract
PIP: Menstrual blood loss (MBL) was evaluated in 74 nulliporous Kenyan women aged between 20 and 27 years. The hemoglobin levels were all in normal range with the mean of 13.65 +or- 0.8, 13.84 +or- 1.2 and 13.04 +or- 1.2 g/100 ml respectively in 3 populations. The MBL was comparable in the 3 populations with the mean of 35.1 +or- 12.6, 30.6 +or- 8.7 and 32.2 +or- 9.4 ml respectively. There was no difference of statistical significance between the 2 periods studied per each individual. This study objectively assesses the menstrual blood loss in 3 population groups–2 urban and 1 rural. The data can be used to evaluate menstrual blood loss before and after initiation of various contraceptives used in Kenya. Subjects were volunteers who were not on any contraception except barrier or natural rhythm methods, not under psychological stress and who exhibited normal physical female characteristics on examination. Those who wished to drop out, became pregnant or desired contraception, were excluded. The study confirms the individual constancy of the menstrual blood loss in this population. This has important practical implications since a single determination of the menstrual blood loss may be a fairly good expression for the average blood loss in a woman. The immediate effect of various treatments such as IUD insertion or oral contraceptives on the MBL may easily be evaluated quantitatively by measurements in consecutive periods using only 1 period as a control. The quick method can be easily used in evaluating pathological conditions e.g. iron-deficiency due to heavy bleeding, IUD-associated hemorrhage, menorrhagia and uterine fibroid. PMID: 12267056 [PubMed - indexed for MEDLINE]
S PROFIGONSANGWASHIBAIRO. "Effect of ethephon on growth, yield and yield components of beans (Phaseolus vulgaris L.). Journal of Agriculture, Science and Technology, 5: 22-38.". In: Proceedings. 6th triennial congress of the African Potato Association (APA). 5-10 April, 2004. Agadir, Morocco. Pp.298-299. Taylor & Francis; 2003. Abstract
Normal 0 false false false MicrosoftInternetExplorer4 st1:*{behavior:url(#ieooui) } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} Hepatocellular carcinoma results when cancerous cells are localized in the liver. It is distributed globally with high prevalence in sub-Saharan African, southern Asia, China and Japan. Diagnosis is experimental and in many cases inaccurate due to unreliability of markers. Prognosis is poor and the cost of treatment prohibitive. Conventional radiation and chemotherapy lead to loss of hair, fertility and general weakening of the body`s immune system increasing a patient`s risk to infection. These observations underscore the need for improved, or additional methods of cancer diagnosis and management. We investigated the effect of polysaccharide rich Pleurotus pulmonarius fruit body extracts on progression of chemically induced hepatocellular carcinoma in CBA mice. Addition of Pleurotus pulmonarius extracts in diet delayed progression of carcinogenesis suggesting   that these extracts may be useful as   adjuvants to conventional cancer therapies.   Key words: carcinogenesis; mice; mushroom extracts; pleurotus pulmunarius   Corresponding author: Ms Carolyne Wasonga, Department of Biochemistry, University of Nairobi, P.O. Box 30197, Nairobi,  Kenya. E-mail: carox27@yahoo.ca     Charles O.A. Omwandho, Susanne E. Gruessner, John Falconer, Hans-R Tinneberg, Timothy K. Roberts. IS OVINE PLACENTAL IGG TOXIC TO HUMAN PERIPHERAL BLOOD NATURAL KILLER CELLS?
S PROFKIGONDUCHRISTINE. "D.O.Ochiel, EOWango, C Sekadde-Kigondu et al. Effect of Menstrual cycle on local mucosal imuunity to SHIV within the reproductive tract of Baboons (Papio anubis): preliminary findings. Journal of Medical Primatology 32, 161 2003.". In: Journal of Medical Primatology 32, 161 2003. uon press; 2003. Abstract
The presence of human immunodeficiency virus (HIV) in genital secretions is regarded as a risk factor for sexual and perinatal transmission of HIV. A better understanding of correlates of genital shedding of HIV is crucial to the development of effective strategies against transmission of this virus. Events during menstrual cycle are likely to influence local immune responses and viral load in genital secretions, and hence determine susceptibility to HIV or efficiency of virus transmission. We report, in this study, preliminary findings on the relationship of menstrual cycle to genital mucosal and systemic immunity in female olive baboons (Papio anubis) experimentally inoculated with simian/human immunodeficiency virus (SHIV)89.6P.
S PROFKIGONDUCHRISTINE. "Jeldesa, G.W., Qureshi, Z.P., Sekadde-Kigondu, C.B., Factors Enhansing the Practice of Female Genital Mutilation among Kenyan Somalis. J. Obstet.Gynaecol.E. and Centr. Afr. 14: 110, 1998.". In: J. Obstet.Gynaecol.E. and Centr. Afr. 14: 110, 1998. uon press; 1998. Abstract
Aga Khan Hospital, Nairobi. Forty females, age 14 to 35 years (mean 28.6 years) with chronic renal failure (CRF) were included in the study. Their menstrual patterns were noted. The function of their hypothalamo-pituitary-ovarian axis was assessed by the serum levels of follicle stimulating hormone (FSH), Luteinising hormone (LH), prolactin (PrL), estradiol (E2) and progesterone (P) at different phases of the menstrual cycle in patients who continued to have normal menses (Group 1) and at weekly intervals for six weeks in patients with menstrual disturbances (Group II). The mean hormone levels during the initial contact Luteal phase in group I were FSH 12.0 IU/L (N, 1.0-3.0 IU/L), LH 1.8IU/L (N 1.5-101U/L), PrL 652mIU/L (N, 100-600 mIU/L) mE2 160 pmol/L (N 400-1400 pmol/L) and P5 nmol/L (N 14-60 nmol/L) for group I. Corresponding values for group II were 1.2, 10.3, 250, 600 and 3.0 in relevant units. All patients (fourteen) with end stage renal disease (ESRD) had amenorrhoae. On the other hand, most patients with stable CRF (22/26) had normal menses. Following initiation of therapy (conservative or dialytic), there was no significant alteration in the hormonal profile or menstrual pattern. We conclude that other factors apart from the hormonal imbalances, may be responsible for the menstrual disturbances noted in patients with CRF.
S PROFMASINDEMICHAEL. "Masinde, M. S. et al. Observer variation in estimation of Cup Disc Ratio as a screening test for chronic simple glaucoma. East African Journal of Ophthalmology 8: 1 .". In: East African Journal of Ophthalmology 8: 1 .; 1988. Abstract
OBJECTIVE: To determine the prevalence of Xerophthalmia among Kenyan children aged four to seven years in high risk using Conjuctival Impression Cytology and transfer. DESIGN: A cross sectional community based study. SETTING: Mathare slum in Nairobi and Tiva/Ithiani area of Kitui. SUBJECTS: Children aged four to seven years residing in the above areas were assessed for both clinical and cytological features of vitamin A deficiency. RESULTS: Of the 342 children included in this study, 316 (92.0%) were normal, five (1.5%) had XN, 19 (5.9% had XIA and two (0.6%) had XIB. No signs of corneal Xerophthalmia were seen in this study. Conjuctival impression cytology and transfer (CICT) was used to asses for squamous metaplastic changes associated with Vitamin A deficiency (VAD). Seventy five (23.1%) of the children were normal by CICT while 249 (76.9%) were abnormal. In comparing the two areas of study, only 13.2% of the children in Mathare had normal CICT compared to 50% in Kitui. For each of the age groups studied there was significant difference between the two areas with children from Mathare being more deficient than those from Kitui. CONCLUSION: VAD is a significant health problem in the high risk areas assessed by CICT in this study.
S PROFKIGONDUCHRISTINE. "Wanjala, SM, Onyango, GK, Sekadde-Kigondu, CB A prospective Study on the Treatment of Oligospermia with Tomoxifene at kenyatta national Hospital. J. Obstet Gyneacol for East And Central Africa. 10(1), 31, 1992.". In: J. Obstet Gyneacol for East And Central Africa. 10(1), 31, 1992. uon press; 1992. Abstract
Forty females, age 14 to 35 years (mean 28.6 years) with chronic renal failure (CRF) were included in the study. Their menstrual patterns were noted. The function of their hypothalamo-pituitary-ovarian axis was assessed by the serum levels of follicle stimulating hormone (FSH), Luteinising hormone (LH), prolactin (PrL), estradiol (E2) and progesterone (P) at different phases of the menstrual cycle in patients who continued to have normal menses (Group 1) and at weekly intervals for six weeks in patients with menstrual disturbances (Group II). The mean hormone levels during the initial contact Luteal phase in group I were FSH 12.0 IU/L (N, 1.0-3.0 IU/L), LH 1.8IU/L (N 1.5-101U/L), PrL 652mIU/L (N, 100-600 mIU/L) mE2 160 pmol/L (N 400-1400 pmol/L) and P5 nmol/L (N 14-60 nmol/L) for group I. Corresponding values for group II were 1.2, 10.3, 250, 600 and 3.0 in relevant units. All patients (fourteen) with end stage renal disease (ESRD) had amenorrhoae. On the other hand, most patients with stable CRF (22/26) had normal menses. Following initiation of therapy (conservative or dialytic), there was no significant alteration in the hormonal profile or menstrual pattern. We conclude that other factors apart from the hormonal imbalances, may be responsible for the menstrual disturbances noted in patients with CRF.
S PROFOLIECHJOSEPH. "A review f thyroid cancer at KNH. Medicom Vol. 2:3, 1980.". In: Medicom Vol. 2:3, 1980. PROF.J.S.OLIECH; 1980. Abstract

No ABSTRACT.

This a report of thirty patients who presented at Kenyatta National Hospital( KNH),Uinversity Of Nairobi (UON) during the three year period January 1974-December 1976 with a diagnosis of thyroid carcinoma.Fourteen had follicular, eight papiilary,four anaplastic,and four medullary types.
Eight patients had metastatic deposits in lymph nodes,lung,or bone and majority of these were anaplastic.Twenty patients received surgical treatment.Five total thyroidectomy, 12 had subtotal thyroidectomy,3 had hemithyroidectomy and 2 had radioactive iodine treatment without surgery.
Most patients received subtotal thyroidectomy with or without radiotherapy. The anaplastic cancers had the poorest prognosis, all dying within six months of diagnosis.Early diagnosis with frozen section the papillary/follicular possess good prognosis if appropriate surgical treatment of subtotal or hemithyroidectomy is done.
abstract yet

S PROFKIGONDUCHRISTINE. "Ogutu G.W., Sekadde-Kigondu C.B., Njoroge J.K. Mati J.K.G. A prospective study of dysfunctional uterine bleeding at Kenyatta National Hospital J. Obstet. Gynaecol. 4 : 23, 1985.". In: E. Afr. Med. J., 64 (7) 442, 1987. uon press; 1985. Abstract

PIP: 125 black Kenyan women attending the Kenyatta National Family Welfare Clinic were randomly allocated to combined and fixed dose oral contraceptives (Eugynon: 500 mcg dl-norgestrel + 50 mcg ethinyl estradiol or Microgynon: 150 mcg levonorgestel + 30 mcg ethinyl estradiol). They were between 18-33 years of age with a mean of 25 +or- 7 years. The mean parity of this group was 3 and they had a mean education standard of 8 years. Fasting blood sampled were taken on recruitment (control cycle) and thereafter once for cycles 1, 3, 6, 9, and 12 during OC use. HDL-cholesterol was estimated in the sear. The 2 OCs elicited a significant decrease in levels of HDL-cholesterol (p0.01). author's modified

S K, Nafukko FM, Ombega JN, Muriuki G. "Evaluation of Training Programmes for the professionals." Pharmacotherapy and Drug Information Journal-E.A. Edition. 2000;II(5).
S PROFKIGONDUCHRISTINE. "Karanja J.G., Gwayi-Chore M.O., Sekadde-Kigondu C.B.,Lequin R.M., Mati J.K.G.J. Obstet. Gynaecol. E. Central Afr. 1:140, 1982 Hormonal patterns during the menstrual cycle of healthy black Kenyan women.". In: Obstet. Gynaecol. E. Central Afr. 1:140, 1982. uon press; 1982. Abstract
PIP: Menstrual blood loss (MBL) was evaluated in 74 nulliporous Kenyan women aged between 20 and 27 years. The hemoglobin levels were all in normal range with the mean of 13.65 +or- 0.8, 13.84 +or- 1.2 and 13.04 +or- 1.2 g/100 ml respectively in 3 populations. The MBL was comparable in the 3 populations with the mean of 35.1 +or- 12.6, 30.6 +or- 8.7 and 32.2 +or- 9.4 ml respectively. There was no difference of statistical significance between the 2 periods studied per each individual. This study objectively assesses the menstrual blood loss in 3 population groups–2 urban and 1 rural. The data can be used to evaluate menstrual blood loss before and after initiation of various contraceptives used in Kenya. Subjects were volunteers who were not on any contraception except barrier or natural rhythm methods, not under psychological stress and who exhibited normal physical female characteristics on examination. Those who wished to drop out, became pregnant or desired contraception, were excluded. The study confirms the individual constancy of the menstrual blood loss in this population. This has important practical implications since a single determination of the menstrual blood loss may be a fairly good expression for the average blood loss in a woman. The immediate effect of various treatments such as IUD insertion or oral contraceptives on the MBL may easily be evaluated quantitatively by measurements in consecutive periods using only 1 period as a control. The quick method can be easily used in evaluating pathological conditions e.g. iron-deficiency due to heavy bleeding, IUD-associated hemorrhage, menorrhagia and uterine fibroid. PMID: 12267056 [PubMed - indexed for MEDLINE]
S PROFIGONSANGWASHIBAIRO. "Effect of packaging materials on weight loss and nutrient quality changes of recharged sweet potatoes (Ipomoea batats Poir) during short-term storage. Journal of Agriculture, Science and Technology.6: 29-47.". In: In press. African Crop Science Proceedings 7: -. Taylor & Francis; 2004. Abstract
Normal 0 false false false MicrosoftInternetExplorer4 st1:*{behavior:url(#ieooui) } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} Hepatocellular carcinoma results when cancerous cells are localized in the liver. It is distributed globally with high prevalence in sub-Saharan African, southern Asia, China and Japan. Diagnosis is experimental and in many cases inaccurate due to unreliability of markers. Prognosis is poor and the cost of treatment prohibitive. Conventional radiation and chemotherapy lead to loss of hair, fertility and general weakening of the body`s immune system increasing a patient`s risk to infection. These observations underscore the need for improved, or additional methods of cancer diagnosis and management. We investigated the effect of polysaccharide rich Pleurotus pulmonarius fruit body extracts on progression of chemically induced hepatocellular carcinoma in CBA mice. Addition of Pleurotus pulmonarius extracts in diet delayed progression of carcinogenesis suggesting   that these extracts may be useful as   adjuvants to conventional cancer therapies.   Key words: carcinogenesis; mice; mushroom extracts; pleurotus pulmunarius   Corresponding author: Ms Carolyne Wasonga, Department of Biochemistry, University of Nairobi, P.O. Box 30197, Nairobi,  Kenya. E-mail: carox27@yahoo.ca     Charles O.A. Omwandho, Susanne E. Gruessner, John Falconer, Hans-R Tinneberg, Timothy K. Roberts. IS OVINE PLACENTAL IGG TOXIC TO HUMAN PERIPHERAL BLOOD NATURAL KILLER CELLS?
S PROFKIGONDUCHRISTINE. "Ruminjo JK, Sekadde-Kigondu CB, Karanja JG, Rivera R, Nasution M, Nutley T. Comparative acceptability of combined and progestin-only injectable contraceptives in Kenya. Contraception. 2005 Aug;72(2):138-45.". In: Contraception. 2005 Aug;72(2):138-45. uon press; 2005. Abstract
OBJECTIVE: We compared 12-month continuation rates, menstrual bleeding patterns and other aspects of acceptability between users of Cyclofem and users of Depo-Provera. METHODS: The life-table method was used to calculate quarterly continuation rates. In all, 360 Kenyan women were randomly assigned to one of the two contraceptives. User-satisfaction questionnaires were administered at 6 and 12 months or at discontinuation, whichever occurred first. RESULTS: The 1-year continuation rate was 75.4% for Depo-Provera users versus 56.5% for Cyclofem users (p<.001). Main reasons for discontinuation included difficulty making clinic visits (45.1% for Cyclofem vs. 40% for Depo-Provera), menstrual changes (14.1% vs. 12.5%) and nonmenstrual problems (15.5% vs. 12.5%). None of the Depo-Provera users and 8.5% of the Cyclofem users claimed frequency of visits as the main reason for discontinuation. In all, 70.6% of the Depo-Provera users were amenorrheic after 12 months, as were 20.8% of the Cyclofem users. CONCLUSIONS: The 1-year continuation rate was higher for Depo-Provera than for Cyclofem. There was no important difference in discontinuation rates because of menstrual problems; the difference mainly reflected the frequency of visits required.
S BRS, Pappu HR, Sseruwagi, P. M, R.D N. "First Report of Iris yellow spot virus in Onion in Kenya and Uganda." Plant Disease . 2011;95(1195).
S PROFKIGONDUCHRISTINE. "Mueke, S.W., Njenga, E.M., Sekadde-Kigondu,C.B.,Ruminjo, J.K., amd Ojwang, S.O.B., the Prevalence of Menstrual Disorders in Reproductive Diabetic Women in Kenya: A Comprehensive Study. J. Obstet.Gynaecol, E. and Centr. Afr, 14; 62, 1998.". In: East Afr Med J. 1993 Jan;70(1):6-9. uon press; 1998. Abstract
Aga Khan Hospital, Nairobi. Forty females, age 14 to 35 years (mean 28.6 years) with chronic renal failure (CRF) were included in the study. Their menstrual patterns were noted. The function of their hypothalamo-pituitary-ovarian axis was assessed by the serum levels of follicle stimulating hormone (FSH), Luteinising hormone (LH), prolactin (PrL), estradiol (E2) and progesterone (P) at different phases of the menstrual cycle in patients who continued to have normal menses (Group 1) and at weekly intervals for six weeks in patients with menstrual disturbances (Group II). The mean hormone levels during the initial contact Luteal phase in group I were FSH 12.0 IU/L (N, 1.0-3.0 IU/L), LH 1.8IU/L (N 1.5-101U/L), PrL 652mIU/L (N, 100-600 mIU/L) mE2 160 pmol/L (N 400-1400 pmol/L) and P5 nmol/L (N 14-60 nmol/L) for group I. Corresponding values for group II were 1.2, 10.3, 250, 600 and 3.0 in relevant units. All patients (fourteen) with end stage renal disease (ESRD) had amenorrhoae. On the other hand, most patients with stable CRF (22/26) had normal menses. Following initiation of therapy (conservative or dialytic), there was no significant alteration in the hormonal profile or menstrual pattern. We conclude that other factors apart from the hormonal imbalances, may be responsible for the menstrual disturbances noted in patients with CRF.
S PROFMASINDEMICHAEL. "Masinde, M. S., Othero, F. A Comparison of drop of intraocular pressure between pilocarpine 2% and levobunolol 0.5%. E. African Journal of Ophthalmology 8: 13 .". In: E. African Journal of Ophthalmology 8: 13 .; 1992. Abstract
OBJECTIVE: To determine the prevalence of Xerophthalmia among Kenyan children aged four to seven years in high risk using Conjuctival Impression Cytology and transfer. DESIGN: A cross sectional community based study. SETTING: Mathare slum in Nairobi and Tiva/Ithiani area of Kitui. SUBJECTS: Children aged four to seven years residing in the above areas were assessed for both clinical and cytological features of vitamin A deficiency. RESULTS: Of the 342 children included in this study, 316 (92.0%) were normal, five (1.5%) had XN, 19 (5.9% had XIA and two (0.6%) had XIB. No signs of corneal Xerophthalmia were seen in this study. Conjuctival impression cytology and transfer (CICT) was used to asses for squamous metaplastic changes associated with Vitamin A deficiency (VAD). Seventy five (23.1%) of the children were normal by CICT while 249 (76.9%) were abnormal. In comparing the two areas of study, only 13.2% of the children in Mathare had normal CICT compared to 50% in Kitui. For each of the age groups studied there was significant difference between the two areas with children from Mathare being more deficient than those from Kitui. CONCLUSION: VAD is a significant health problem in the high risk areas assessed by CICT in this study.
S PROFKIGONDUCHRISTINE. "Rukaria,RM, Sekadde-Kigondu CB and . Oyieke. JB. A knowlegde , attitude and practice survey on sexually transmitted diseases among undergraduate female and male students in a university in Kenya.J. Obstet. Gynaecol E.and Centr. Afric 11: 3, 1993.". In: J. Obstet. Gynaecol E.and Centr. Afric 11: 3, 1993. uon press; 1993. Abstract
Normal postpartum women, who had a spontaneous vaginal delivery of one full-term male infant, free of congenital abnormalities and other diseases, were recruited for this study. Thirteen women received 150 mg depot-medroxy-progesterone acetate (DMPA), intramuscularly on days 42 + 1 and 126 + 1 postpartum. Infants of nine mothers, who did not receive DMPA, served as controls. Blood samples were collected from treated mothers on days 44, 47, 74, 124, 128, and 130 postpartum for medroxyprogesterone acetate (MPA) measurements. Four-hour urine collections were obtained from all 22 infants in the morning on days 38, 40, 42, 44, 46, 53, 60, 67, 74, 88, 102, 116, 122, 124, 126, 128, 130, and 137. Urinary follicle stimulating hormone (FSH), luteinizing hormone (LH), unconjugated testosterone, and unconjugated cortisol were measured by radioimmunoassay, and serum MPA and urinary MPA metabolites were measured by gas chromatography-mass spectrometry (GC-MS). No MPA metabolites could be detected in the urine of the infants from the DMPA-receiving mothers. Hormonal profiles in the urine samples were not suppressed in comparison with those of the control infants. The present study demonstrates that DMPA, administered to the mother, does not influence the hormonal regulation of the breast-fed normal male infant.
S PROFOLIECHJOSEPH. "The use of fine needle aspiration in urological practice Medicom 1985.". In: Assoc. of Surgeons of E.A. proceedings Dec. 1985. PROF.J.S.OLIECH; 1985. Abstract
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S PROFKIGONDUCHRISTINE. "Maina F.W., Sekadde-Kigondu C.B., Ojwang P.J., Mati J.K.G. The effects of Oral Contraceptives on body weight and blood pressure in indigenous Kenyan women. J. Obstet. Gynaecol. E. and Central Afr. 6 (2), 97, 1987.". In: J. Obstet. Gynaecol. E. and Central Afr. 6 (2), 97, 1987. uon press; 1987. Abstract
Kenya Medical Research Institute, Clinical Research Centre, Nairobi. Twenty nine patients with rickets were studied in a one year period. The majority of patients (17/29) were below 2 years of age. Most of them had nutritional rickets resulting from a combination of factors. Premature delivery, nonexposure to sunlight, nutritional marasmus and inappropriate dietary intake. Some had familial hypophosphataemic rickets, others had renal tubular acidosis while the rest had rickets with a familial tendency. Both the previous hospital records and the present study indicate that rickets is a persistent problem in children in the community and should be suspected in children who present with features of failure to thrive, among other conditions.
S PROFKIGONDUCHRISTINE. "Nana O.F., Mati J.K.G., Lequin R.M., Sekadde-Kigondu C.B.,J. Obster. Gynaecol. E. and Central Africa, 1:1, 42, 1982:Pituitary-Ovarian Function during and afterpelvic Irradiation for carcinoma of the cervix.". In: Obster. Gynaecol. E. and Central Africa, 1:1, 42, 1982:. uon press; 1982. Abstract
PIP: Menstrual blood loss (MBL) was evaluated in 74 nulliporous Kenyan women aged between 20 and 27 years. The hemoglobin levels were all in normal range with the mean of 13.65 +or- 0.8, 13.84 +or- 1.2 and 13.04 +or- 1.2 g/100 ml respectively in 3 populations. The MBL was comparable in the 3 populations with the mean of 35.1 +or- 12.6, 30.6 +or- 8.7 and 32.2 +or- 9.4 ml respectively. There was no difference of statistical significance between the 2 periods studied per each individual. This study objectively assesses the menstrual blood loss in 3 population groups–2 urban and 1 rural. The data can be used to evaluate menstrual blood loss before and after initiation of various contraceptives used in Kenya. Subjects were volunteers who were not on any contraception except barrier or natural rhythm methods, not under psychological stress and who exhibited normal physical female characteristics on examination. Those who wished to drop out, became pregnant or desired contraception, were excluded. The study confirms the individual constancy of the menstrual blood loss in this population. This has important practical implications since a single determination of the menstrual blood loss may be a fairly good expression for the average blood loss in a woman. The immediate effect of various treatments such as IUD insertion or oral contraceptives on the MBL may easily be evaluated quantitatively by measurements in consecutive periods using only 1 period as a control. The quick method can be easily used in evaluating pathological conditions e.g. iron-deficiency due to heavy bleeding, IUD-associated hemorrhage, menorrhagia and uterine fibroid. PMID: 12267056 [PubMed - indexed for MEDLINE]
S Masoud AK, JOSHI MD, Otieno CF, Acharya K. "P24 Quality of glycemic control among insulin treated ambulatory patients with diabetes mellitus at Kenyatta national hospital." Diabetes Research and Clinical Practice. 2014;103:s39. AbstractWebsite

Methods: Retrospective study was done and analysed by SPSS programm version 15, whereby a total of 652 patients aged above 18 years, tested for lipids profile and using HAART for not less than 9 months were recruited from 5 care and treatment centres out of 15 centres from Ilala district in Dar es salaam. This study was done for one year from January, 2011 to December 2011. Results: Out of 652 people living with HIV/AIDS 332 (50.9%) were females and 320 (49.1%) were males. About 60% of participants were obese, and about ...

S. PROFNTEEREJACOB. "The contributions of Reginald Brabazon.". In: University of Manchester, 1989. Institute of African Studies, University of Nairobi; 1981. Abstract
Introduction The Centre for Open and Distance Learning has been established to facilitate the Internal Faculties in launching and managing their programmes using distance mode with a view to increasing access to university education and provide equity in higher education to the learners all over the country. Operational Strategies The operational strategies that have been set up involve collaborative arrangements between the CODL and the Internal Faculties in the development of Study Materials and Learner support Services for off-campus students. The professional in open and distance learning are availed by the Centre to serve the Faculties as trainers while the Faculties provide academic expertise who are facilitated through participatory methods involving application of knowledge, skills and strategies to develop study materials in their respective subjects. Focus The Centre is currently working with Faculties of Science, Commerce and Arts. The Material development process involves training, writing, reviewing and editing followed by conversion to e-content and audio modes. Conclusion These collaborative arrangements will increase access to higher education make significant contribution in the realization of educational Millennium Goals in Kenya where only 20% of all those who qualify obtain admission in the public universities.
S. PROFAKUNDABWENILEVI. "Maobe S. N, L.S.M Akundabweni, M.W.K. Mburu, Ndufa J.K. J.G. Mureithi, C.C.K Gachene, F.W. Makini and J.J. Okello. 2010. Effect of Green manure and inorganic Fertilizer Urea Nitrogen Sources And Application Rates on Harvest of maize (Zea mays L.).". In: World Journal of Agric Scie 6 (5) 532-539. Paraclete Publishers; 2010. Abstract
AbstractOn-farm experiment was carried out in southwest Kenya in the period 2002 to 2005. The objective was to determine the most profitable source of nitrogen for maize production, and assess various application quantities to identify the most profitable rate. Treatments investigated were: mucuna green manure applied at rates of 30, 60, 120, 240 and 480 kg N ha-1; inorganic fertilizer-urea ratesof 0, 30, 60 and 120 kg N ha-1. At tissue N concentration of 1.85 to 2 % for mucuna, the rates worked to 1.5, 3, 6, 12 and 24 t DM ha-1 equivalent of its green biomass, respectively. Randomized complete block design with four replications was used. Data was collected on maize grain yield and price, costof mucuna N and its application. Procedures applied in economic analysis were net benefits, dominance and marginal analyses. The beneficial rate of mucuna green manure was 6 t DM ha-1 to supply 120 kg N ha-1 with marginal rate of return (MRR) of 123%. In absence of capital to invest in mucuna N production, the inorganic fertilizer rate of 60 kg N ha-1 is profitable and can be used butwith expectation of comparatively lower MRR of 73%. In the absence of required capital to produce the target 120 kg N ha-1 equivalent of mucuna biomass, application of inorganic N at 30 kg ha-1 is the most beneficial practice in all seasons. Lower application rates might require supplementation withinorganic N to make up to the required amount.
S. PROFMBINDYOBENJAMIN. "Mbindyo, B.S., Malibo, J. Some considerations in cases of fractures of he femur treated by intramedullary nailing. Proc. Ass. of Surgeons of E.A.". In: Proc. Ass. of Surgeons of E.A. University of Nairobi.; Submitted. Abstract
Kenya is a country of marked environmental and ethnic diversity. A study of osteogenic sarcoma occurring in Kenya from 1968 to 1978 revealed 251 cases, representing between 89% and 100% of the predicted number. Variations in age, sex and anatomical location were within classical limits. However, the incidence of osteogenic sarcoma amongst the Central Bantu was significantly higher than predicted (P less than 0.0001), whilst the incidence among the Western Bantu was significantly lower (P less than 0.002), despite their similar ethnic origins. Two geographically dissimilar areas likewise exhibited significant differences in incidence. The Eastern province showed a higher incidence (P less than 0.02), whereas the Nyanza Province (P less than 0.001) and the adjacent Western Province (P less than 0.005) showed a lower than predicted incidence. These observations suggest that in Kenya a geomedical variable affects the incidence of osteogenic sarcoma and that genetic variation has no effect on incidence.
S. PROFNTEEREJACOB. "The structure and Organization of Sport in Kenya.". In: University of Manchester, 1989. Institute of African Studies, University of Nairobi; 1989. Abstract
Introduction The Centre for Open and Distance Learning has been established to facilitate the Internal Faculties in launching and managing their programmes using distance mode with a view to increasing access to university education and provide equity in higher education to the learners all over the country. Operational Strategies The operational strategies that have been set up involve collaborative arrangements between the CODL and the Internal Faculties in the development of Study Materials and Learner support Services for off-campus students. The professional in open and distance learning are availed by the Centre to serve the Faculties as trainers while the Faculties provide academic expertise who are facilitated through participatory methods involving application of knowledge, skills and strategies to develop study materials in their respective subjects. Focus The Centre is currently working with Faculties of Science, Commerce and Arts. The Material development process involves training, writing, reviewing and editing followed by conversion to e-content and audio modes. Conclusion These collaborative arrangements will increase access to higher education make significant contribution in the realization of educational Millennium Goals in Kenya where only 20% of all those who qualify obtain admission in the public universities.
S. PROFAKUNDABWENILEVI. "Levi-Shadeya-M Akundabweni, R.W. Munene, D M Maina and S.K Bartilol. 2010. Mineral Micronutrient Density in Local Cereals Sample from Bungoma, Maseno and Kibwezi areas. (AJFAND) 10: 11 (2010).". In: (AJFAND) 10: 11 (2010). Paraclete Publishers; 2010. Abstract
AbstractOn-farm experiment was carried out in southwest Kenya in the period 2002 to 2005. The objective was to determine the most profitable source of nitrogen for maize production, and assess various application quantities to identify the most profitable rate. Treatments investigated were: mucuna green manure applied at rates of 30, 60, 120, 240 and 480 kg N ha-1; inorganic fertilizer-urea ratesof 0, 30, 60 and 120 kg N ha-1. At tissue N concentration of 1.85 to 2 % for mucuna, the rates worked to 1.5, 3, 6, 12 and 24 t DM ha-1 equivalent of its green biomass, respectively. Randomized complete block design with four replications was used. Data was collected on maize grain yield and price, costof mucuna N and its application. Procedures applied in economic analysis were net benefits, dominance and marginal analyses. The beneficial rate of mucuna green manure was 6 t DM ha-1 to supply 120 kg N ha-1 with marginal rate of return (MRR) of 123%. In absence of capital to invest in mucuna N production, the inorganic fertilizer rate of 60 kg N ha-1 is profitable and can be used butwith expectation of comparatively lower MRR of 73%. In the absence of required capital to produce the target 120 kg N ha-1 equivalent of mucuna biomass, application of inorganic N at 30 kg ha-1 is the most beneficial practice in all seasons. Lower application rates might require supplementation withinorganic N to make up to the required amount.
S. PROFEL-BUSAIDYABDULGAFURH. "The Survey of the Extent of Corrosion Problems in Kenya". Final Report to the National Council for Science & Technolog.". In: Houston, Texas. J. Kenya Meteorological Soc; 1976. Abstract
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S. PROFMBINDYOBENJAMIN. "Mbindyo, B.S., Okelo, G.B.A. Common Venomous Bites and Stings in Kenya A book published by Health Education Division and audio-visual Centre, Serial No. 1/79.". In: A book published by Health Education Division and audio-visual Centre, Serial No. 1/79. University of Nairobi.; Submitted. Abstract
Kenya is a country of marked environmental and ethnic diversity. A study of osteogenic sarcoma occurring in Kenya from 1968 to 1978 revealed 251 cases, representing between 89% and 100% of the predicted number. Variations in age, sex and anatomical location were within classical limits. However, the incidence of osteogenic sarcoma amongst the Central Bantu was significantly higher than predicted (P less than 0.0001), whilst the incidence among the Western Bantu was significantly lower (P less than 0.002), despite their similar ethnic origins. Two geographically dissimilar areas likewise exhibited significant differences in incidence. The Eastern province showed a higher incidence (P less than 0.02), whereas the Nyanza Province (P less than 0.001) and the adjacent Western Province (P less than 0.005) showed a lower than predicted incidence. These observations suggest that in Kenya a geomedical variable affects the incidence of osteogenic sarcoma and that genetic variation has no effect on incidence.
S. PROFNTEEREJACOB. ""The structure and Organization of sport in Kenya and Malawi" in Sports for All into the 90s I.S.C.P.E.S" volume 7, Meyer & Mayer Verlag, Aachen Germany, 1991.". In: 8th Biennal Conference of I.S.C.P.E.S, Houston, June 12-18 1992. Institute of African Studies, University of Nairobi; 1991. Abstract
Introduction The Centre for Open and Distance Learning has been established to facilitate the Internal Faculties in launching and managing their programmes using distance mode with a view to increasing access to university education and provide equity in higher education to the learners all over the country. Operational Strategies The operational strategies that have been set up involve collaborative arrangements between the CODL and the Internal Faculties in the development of Study Materials and Learner support Services for off-campus students. The professional in open and distance learning are availed by the Centre to serve the Faculties as trainers while the Faculties provide academic expertise who are facilitated through participatory methods involving application of knowledge, skills and strategies to develop study materials in their respective subjects. Focus The Centre is currently working with Faculties of Science, Commerce and Arts. The Material development process involves training, writing, reviewing and editing followed by conversion to e-content and audio modes. Conclusion These collaborative arrangements will increase access to higher education make significant contribution in the realization of educational Millennium Goals in Kenya where only 20% of all those who qualify obtain admission in the public universities.
S. PROFAKUNDABWENILEVI. "Evaluation of elite lines of cowpea (Vigna unguiculata (L ) for leaf fodder cum grain.". In: Tropical Agriculture (Trinidad) 67: 133. NISC Pty Ltd; 1989.
S. PROFMBINDYOBENJAMIN. "Mbindyo, B.S.Considerations on Cases of epiphyseal injury observed at the Kenyatta National Hospital E.A.M.J. vol. 56 No. 9 Sept. 1978.". In: E.A.M.J. vol. 56 No. 9 Sept. 1978. University of Nairobi.; 1978. Abstract
Kenya is a country of marked environmental and ethnic diversity. A study of osteogenic sarcoma occurring in Kenya from 1968 to 1978 revealed 251 cases, representing between 89% and 100% of the predicted number. Variations in age, sex and anatomical location were within classical limits. However, the incidence of osteogenic sarcoma amongst the Central Bantu was significantly higher than predicted (P less than 0.0001), whilst the incidence among the Western Bantu was significantly lower (P less than 0.002), despite their similar ethnic origins. Two geographically dissimilar areas likewise exhibited significant differences in incidence. The Eastern province showed a higher incidence (P less than 0.02), whereas the Nyanza Province (P less than 0.001) and the adjacent Western Province (P less than 0.005) showed a lower than predicted incidence. These observations suggest that in Kenya a geomedical variable affects the incidence of osteogenic sarcoma and that genetic variation has no effect on incidence.
S. PROFAKUNDABWENILEVI. "Maobe S. N, Mburu M.W. K, Akundabweni L. S, Ndufa J. K, Mureithi J. G, Gachene C. K. K, Okello J. J, Makini F. Effect of Mucuna Green Manure Rate Applied on Maize Grain Yield During the Application Season.". In: J. of Sustainable Development in Agriculture & Environment Vol. 5(1):54-64 Mach. 2010. Paraclete Publishers; 2010. Abstract
AbstractMaize yield in Kenya is constrained by inadequate supply of nitrogen and there is need to search for locally available and potentially low-cost N sources. Consequently, on-farm research was carried out in southwest Kenya in the period 2002-2005. The objective was to evaluate effect of Mucuna pruriens green manure biomass application rate on maize grain yield in sandy clay soil. Treatments evaluated were: mucuna green manure applied at rates of 0, 30, 60, 120, 240 and 480 kg N ha-1; and inorganic fertilizer-urea at 0, 30, 60 and 120 kg N ha-1. The experimental design was randomized complete block with four replications. Results obtained showed that mucuna application rate of 30 kgN ha-1 did not significantly improve maize grain yield. Its application at 60 kg N ha-1 significantly increased maize grain yield only in seasons when rainfall was high notably in long rains. But, mucuna green manure applied at a rate of 120 kg N ha-1 significantly improved maize grain yield in both short and long rain seasons when rainfall amounts received were variable. Application of mucuna green manure at higher rates of 240 and 480 kg N ha-1 made no further significant increase in maize grain yield. Therefore, application rates lower than 120 kg N ha-1 equivalent of mucuna green manure biomass may be inadequate and would require supplementation with inorganic fertilizer N if maize grain yield is to be increased.
S. PROFAKUNDABWENILEVI. "Morphological and soil measurements for determining ecotypic variation in Trifolium tembense in the Ethiopian highlands.". In: Discovery and Innovation 31: 99-104. NISC Pty Ltd; 1991.
S. PROFEL-BUSAIDYABDULGAFURH. "The Development of the Solar Salt Industry in Kenya". A technical.". In: Kenya. J. Kenya Meteorological Soc; 1979. Abstract
   
S. PROFMBINDYOBENJAMIN. "Jeshirani, M.K., Bencivenga, A., Mbindyo, B.S., Heda, P.K., Gakuu, L.N. The management of post-traumatic limb length discrepancies Proc. Ass. of Surgeons of E.A. pp 181-186 vol 5 1982.". In: Ass. of Surgeons of E.A. pp 181-186 vol 5 1982. University of Nairobi.; 1982. Abstract
Kenya is a country of marked environmental and ethnic diversity. A study of osteogenic sarcoma occurring in Kenya from 1968 to 1978 revealed 251 cases, representing between 89% and 100% of the predicted number. Variations in age, sex and anatomical location were within classical limits. However, the incidence of osteogenic sarcoma amongst the Central Bantu was significantly higher than predicted (P less than 0.0001), whilst the incidence among the Western Bantu was significantly lower (P less than 0.002), despite their similar ethnic origins. Two geographically dissimilar areas likewise exhibited significant differences in incidence. The Eastern province showed a higher incidence (P less than 0.02), whereas the Nyanza Province (P less than 0.001) and the adjacent Western Province (P less than 0.005) showed a lower than predicted incidence. These observations suggest that in Kenya a geomedical variable affects the incidence of osteogenic sarcoma and that genetic variation has no effect on incidence.
S. PROFNTEEREJACOB. "PROF. JACOB STANLEY NTEERE, DR. WANDERI & JANET W. KAMENJU, AEROBIC CAPACITY OF KENYAN RUGBY UNION PLAYERS.". In: Seminar, University of Manchester, 1981. Institute of African Studies, University of Nairobi; 1978.
S. PROFAKUNDABWENILEVI. "L. Abscisic acid (ABA) accumulation in roots and leaves of Vigna unguiculata L., Walp. under imposed water stress.". In: Legume Research J. 33:11-13. NISC Pty Ltd; 1995.
S. PROFEL-BUSAIDYABDULGAFURH. "Diffusion of Dissolved Oxygen through Concrete". Material Performance, 12,39-44 (December ).". In: Presented, NUSESA Maintenance of Equipment for the Advancement of Science Regional Conference, Sheraton Hotel, Kampala, Uganda, 3-4 December 2001. J. Kenya Meteorological Soc; 1986.
S. PROFMBINDYOBENJAMIN. "Bovill EG Jr, Kung'u A, Bencivenga A, Jeshrani MK, Mbindyo BS, Heda PM. An epidemiological study of osteogenic sarcoma in Kenya: the variations in incidence between ethnic groups and geographic regions, 1968-1978. Int Orthop. 1985;9(1):59-63.". In: Int Orthop. 1985;9(1):59-63. University of Nairobi.; 1985. Abstract
Kenya is a country of marked environmental and ethnic diversity. A study of osteogenic sarcoma occurring in Kenya from 1968 to 1978 revealed 251 cases, representing between 89% and 100% of the predicted number. Variations in age, sex and anatomical location were within classical limits. However, the incidence of osteogenic sarcoma amongst the Central Bantu was significantly higher than predicted (P less than 0.0001), whilst the incidence among the Western Bantu was significantly lower (P less than 0.002), despite their similar ethnic origins. Two geographically dissimilar areas likewise exhibited significant differences in incidence. The Eastern province showed a higher incidence (P less than 0.02), whereas the Nyanza Province (P less than 0.001) and the adjacent Western Province (P less than 0.005) showed a lower than predicted incidence. These observations suggest that in Kenya a geomedical variable affects the incidence of osteogenic sarcoma and that genetic variation has no effect on incidence.
S. PROFNTEEREJACOB. "The Nature of P.E in the Public Schools of England during the 19th Century. University of Manchester, 1981.". In: University of Manchester, 1989. Institute of African Studies, University of Nairobi; 1981. Abstract
Introduction The Centre for Open and Distance Learning has been established to facilitate the Internal Faculties in launching and managing their programmes using distance mode with a view to increasing access to university education and provide equity in higher education to the learners all over the country. Operational Strategies The operational strategies that have been set up involve collaborative arrangements between the CODL and the Internal Faculties in the development of Study Materials and Learner support Services for off-campus students. The professional in open and distance learning are availed by the Centre to serve the Faculties as trainers while the Faculties provide academic expertise who are facilitated through participatory methods involving application of knowledge, skills and strategies to develop study materials in their respective subjects. Focus The Centre is currently working with Faculties of Science, Commerce and Arts. The Material development process involves training, writing, reviewing and editing followed by conversion to e-content and audio modes. Conclusion These collaborative arrangements will increase access to higher education make significant contribution in the realization of educational Millennium Goals in Kenya where only 20% of all those who qualify obtain admission in the public universities.
S. PROFAKUNDABWENILEVI. "Maobe, S. N Mburu, M.W. K, Ndufa, J. K, Akundabweni, L. S, Mureithi, J. G, Gachene, C. K. K, Makini, F, Okello, J. J. 2010. Potential Effect of Mucuna Green Manure Application Rates on the Decomposition and Availability of Nitrogen in Varying Soil Moistur.". In: World Journal of Agric Scie 6 (5) 532-539. Paraclete Publishers; 2010. Abstract
AbstractOn-farm experiment was carried out in southwest Kenya in the period 2002 to 2005. The objective was to determine the most profitable source of nitrogen for maize production, and assess various application quantities to identify the most profitable rate. Treatments investigated were: mucuna green manure applied at rates of 30, 60, 120, 240 and 480 kg N ha-1; inorganic fertilizer-urea ratesof 0, 30, 60 and 120 kg N ha-1. At tissue N concentration of 1.85 to 2 % for mucuna, the rates worked to 1.5, 3, 6, 12 and 24 t DM ha-1 equivalent of its green biomass, respectively. Randomized complete block design with four replications was used. Data was collected on maize grain yield and price, costof mucuna N and its application. Procedures applied in economic analysis were net benefits, dominance and marginal analyses. The beneficial rate of mucuna green manure was 6 t DM ha-1 to supply 120 kg N ha-1 with marginal rate of return (MRR) of 123%. In absence of capital to invest in mucuna N production, the inorganic fertilizer rate of 60 kg N ha-1 is profitable and can be used butwith expectation of comparatively lower MRR of 73%. In the absence of required capital to produce the target 120 kg N ha-1 equivalent of mucuna biomass, application of inorganic N at 30 kg ha-1 is the most beneficial practice in all seasons. Lower application rates might require supplementation withinorganic N to make up to the required amount.
S. PROFAKUNDABWENILEVI. "Seed production of native hay clovers in the highlands of eastern Africa.". In: Tropical Grasslands Vol. 30. NISC Pty Ltd; 1996.
S. PROFNTEEREJACOB. "The theory of Achivement Motivation and its Applicability to sport and Physical Education University of Manchester, 1982.". In: University of Manchester, 1989. Institute of African Studies, University of Nairobi; 1982. Abstract
Introduction The Centre for Open and Distance Learning has been established to facilitate the Internal Faculties in launching and managing their programmes using distance mode with a view to increasing access to university education and provide equity in higher education to the learners all over the country. Operational Strategies The operational strategies that have been set up involve collaborative arrangements between the CODL and the Internal Faculties in the development of Study Materials and Learner support Services for off-campus students. The professional in open and distance learning are availed by the Centre to serve the Faculties as trainers while the Faculties provide academic expertise who are facilitated through participatory methods involving application of knowledge, skills and strategies to develop study materials in their respective subjects. Focus The Centre is currently working with Faculties of Science, Commerce and Arts. The Material development process involves training, writing, reviewing and editing followed by conversion to e-content and audio modes. Conclusion These collaborative arrangements will increase access to higher education make significant contribution in the realization of educational Millennium Goals in Kenya where only 20% of all those who qualify obtain admission in the public universities.
S. PROFAKUNDABWENILEVI. "Levi-Shadeya-M Akundabweni, G. Mulokozi and D M Maina. 2010. Characterization of African leafy Vegetables for Organo- and Mineral Micronutrient Densities based on X- ray Fluorescence and High Performance Liquid Chromatography. African Journal of Food and .". In: (AJFAND) 10: No. 11 (2010). Paraclete Publishers; 2010. Abstract
AbstractOn-farm experiment was carried out in southwest Kenya in the period 2002 to 2005. The objective was to determine the most profitable source of nitrogen for maize production, and assess various application quantities to identify the most profitable rate. Treatments investigated were: mucuna green manure applied at rates of 30, 60, 120, 240 and 480 kg N ha-1; inorganic fertilizer-urea ratesof 0, 30, 60 and 120 kg N ha-1. At tissue N concentration of 1.85 to 2 % for mucuna, the rates worked to 1.5, 3, 6, 12 and 24 t DM ha-1 equivalent of its green biomass, respectively. Randomized complete block design with four replications was used. Data was collected on maize grain yield and price, costof mucuna N and its application. Procedures applied in economic analysis were net benefits, dominance and marginal analyses. The beneficial rate of mucuna green manure was 6 t DM ha-1 to supply 120 kg N ha-1 with marginal rate of return (MRR) of 123%. In absence of capital to invest in mucuna N production, the inorganic fertilizer rate of 60 kg N ha-1 is profitable and can be used butwith expectation of comparatively lower MRR of 73%. In the absence of required capital to produce the target 120 kg N ha-1 equivalent of mucuna biomass, application of inorganic N at 30 kg ha-1 is the most beneficial practice in all seasons. Lower application rates might require supplementation withinorganic N to make up to the required amount.
S. PROFAKUNDABWENILEVI. "Akuja, T E, Akundabweni, L.S., Chweya, J.A. 2003. Effect of Intercropping Finger Millet with two Indigenous Legumes at different Nitrogen Levels in Kabete and Njoro, Kenya.". In: Eastern Africa Journal of Rural Development Vol. 19, No. 1 (2003). NISC Pty Ltd; 2003.
S. PROFEL-BUSAIDYABDULGAFURH. "X-Ray Fluorescence Analysis (XRF) of Trace Elements in Tuff (Volcanic Soil) and in Tissues of Rats fed with Tuff.". In: Nairobi. J. Kenya Meteorological Soc; 1976. Abstract
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S. PROFMBINDYOBENJAMIN. "Contribution to books on Primary Traumatology Parts i and ii. Published by Kenya/German project for District Hospital, surgery.". In: Published by Kenya/German project for District Hospital, surgery. University of Nairobi.; Submitted. Abstract
Kenya is a country of marked environmental and ethnic diversity. A study of osteogenic sarcoma occurring in Kenya from 1968 to 1978 revealed 251 cases, representing between 89% and 100% of the predicted number. Variations in age, sex and anatomical location were within classical limits. However, the incidence of osteogenic sarcoma amongst the Central Bantu was significantly higher than predicted (P less than 0.0001), whilst the incidence among the Western Bantu was significantly lower (P less than 0.002), despite their similar ethnic origins. Two geographically dissimilar areas likewise exhibited significant differences in incidence. The Eastern province showed a higher incidence (P less than 0.02), whereas the Nyanza Province (P less than 0.001) and the adjacent Western Province (P less than 0.005) showed a lower than predicted incidence. These observations suggest that in Kenya a geomedical variable affects the incidence of osteogenic sarcoma and that genetic variation has no effect on incidence.

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