Therapeutic potential of folate uptake inhibition in Plasmodium falciparum

Citation:
Nzila AM, Kokwaro G, Winstanley PA, Marsh K, Ward SA. "Therapeutic potential of folate uptake inhibition in Plasmodium falciparum.". 2004.

Abstract:

Plasmodium falciparum parasites resistant to the combination sulfadoxine-pyrimethamine are spreading in Africa, particularly in East Africa. This is a matter of concern because there are no other affordable drugs available. This article provides the evidence indicating that sulfadoxine-pyrimethamine resistance can be reversed in vitro and discusses how this information might be exploited to extend the therapeutic lifetime of sulfadoxine-pyrimethamine in vivo

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