Trypanosome Migration to the Brain

Nasimolo. J. Kiama., S.Makanya. A. GKP k J. "Trypanosome Migration to the Brain .". In: 2nd East Africa Neuroscience Conference. Pride Inn Hotel, Westlands Nairobi, Kenya; 2012.

Date Presented:

18-19 June


The migration of trypanosomes into the brain parenchyma is still not well understood, considering the presence of a blood brain barrier. We examined the second stage of trypanosomiasis that occurs in the brain using a mice model. Swiss white mice were infected intraperitonealy with 1x104 T. brucei brucei and parasitaemia monitored from the third day up to 28 days post infection. Diminazine aceturate was given intraperitonealy 21 days post infection. One animal was sacrificed at day 21 post infection to establish whether the parasites had reached the brain.

We established the presence of trypanosomes in the brain from day 21 onwards. Scanning electron microscopy showed trypanosomes in the ventricles and some crossing the choroid plexus, while transmission electron microscopy demonstrated the parasites in brain parenchyma. The results indicate a possible route of invasion of trypanosomes into brain parenchyma, shedding some light on the mechanism of this migration.

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