KARURI PROFGATHUMBIPETER. "
Gakuya,D.W., Mbaria, J.M., Kiama,S.G., Gathumbi, P.K., Mathiu,M., Nguta,J.M. THE PROSPECTS OF INTEGRATING MEDICINAL PLANTS PRODUCTS IN VETERINARY MEDICINE IN KENYA.". In:
7TH BIENNIAL SCIENTIFIC CONFERENCE, 2010, DEPARTMENT OF PUBLIC HEALTH, PHARMACOLOGY AND TOXICOLOGY AUDITORIUM, CAVS. J.M. Nguta,, J.M. Mbaria, D.W. Gakuya, P.K. Gathumbi, S.G. Kiama; 2010.
KARURI PROFGATHUMBIPETER. "
GATHUMBI P.K. EMERGING LIVESTOCK: CURRENT STATUS, GLOBAL PERSPECTIVE WITH A LOCAL FOCUS.". In:
7TH BIENNIAL SCIENTIFIC CONFERENCE, 2010. DEPARTMENT OF PUBLIC HEALTH, PHARMACOLOGY AND TOXICOLOGY AUDITORIUM, CAVS. J.M. Nguta,, J.M. Mbaria, D.W. Gakuya, P.K. Gathumbi, S.G. Kiama; 2010.
AbstractLivestock production in Kenya has largely focused on conventional domestic animals, largely ignoring the existing potential of emerging livestock species as sources of protein and other animal products. Emerging livestock including ostriches, crocodiles, quails, guinea fowls, snakes, ants, snails, frogs and chameleons, bees among others are largely unexploited either due to inadequate information to support their production, lack of sufficient market channels, inadequate policy and legal framework or socio-cultural beliefs that preclude their utilization This paper will focus on the potential opportunities and constraints in production of the main emerging livestock in Kenya including ostriches, crocodiles and quails among others. The existing information on production and marketing of the major emerging livestock will be collated and compared with that from other regions. The current production practices and the main diseases of major emerging livestock will be highlighted. The existing policy and regulatory framework that supports production of emerging livestock in Kenya will be stated. The existing research gaps and opportunities for improved marketing will be discussed. The paper will highlight the existing potential of emerging livestock production to support livelihood, employment and wealth creation in Kenya.
KARURI PROFGATHUMBIPETER. "
Hesbon Z. Amenya, Peter K.Gathumbi and James M. Mbaria ACUTE TOXICITY AND CYTOTOXICITY OF AQUEOUS AND CHLOROFORMIC EXTRACTS OF RAPANEA MELANOPHLOEOS.". In:
7TH BIENNIAL SCIENTIFIC CONFERENCE 2010, DEPARTMENT OF PUBLIC HEALTH, PHARMACOLOGY AND TOXICOLOGY AUDITORIUM, UNIVERSITY OF NAIROBI, COLLEGE OF AGRICULTURE AND VETERINARY SCIENCES. J.M. Nguta,, J.M. Mbaria, D.W. Gakuya, P.K. Gathumbi, S.G. Kiama; 2010.
KARURI PROFGATHUMBIPETER. "
J.M. Nguta, J.M. Mbaria, D.W. Gakuya, P.K. Gathumbi, S.G. Kiama Antimalarial herbal remedies of Msambweni, Kenya.". In:
Journal of Ethnopharmacology 128 (2010) 424. J.M. Nguta,, J.M. Mbaria, D.W. Gakuya, P.K. Gathumbi, S.G. Kiama; 2010.
AbstractMalariaisaseriouscauseofmortalityglobally.The disease is of regional concern in Africa and of national interest in Kenya due to its high morbidity and mortality as a result of development of resistant strains of Plasmodium falciparum to many existing drugs such as chloroquine. Alternative medicine using herbalremedies are commonly used to treat malaria in Kenya. However, plants used in some rural areas in Kenya are not documented. Many antimalarial drugs have been derived from plants. This study was conducted to document medicinal plantsthataretraditionallyusedbytheMsambwenicommunityofKenyanSouth Coast to treat malaria, where the disease is endemic. Herbalists were interviewed by administration of semi structured questionnaires in order to obtain information on medicinal plants traditionally used for the treatment of malaria. Focused group discussions held with the herbalists supplementedthe interview and questionnaire survey. Twenty-seven species of plants in 24 genera distributed in 20 families were reported to be used in this region for the treatment of malaria. Labiatae, Rutaceae and Liliaceae families had each eleven percent of the plant species reported and represented the species that are most commonly used. Thirteen plant species, namely; Aloe deserti Berger (Liliaceae), Launea cornuta (Oliv and Hiern) C. Jeffrey (Compositae), Ocimum bacilicum L. (Labiatae), Teclea simplicifolia (Eng) Verdoon(Rutaceae), Gerranthuslobatus(Cogn.) Jeffrey(Cucurbitaceae), GrewiahexamintaBurret. (Tiliaceae), CanthiumglaucumHiern. (Rubiaceae), AmaranthushybridusL.(Amaranthaceae), CombretumpadoidesEngl and Diels.(Combretaceae), SeneciosyringitoliusO.Hoffman.(Compositae),OcimumsuaveWilld(Labiatae),AloemacrosiphonBak.(Liliaceae)andLaudolphiabuchananii(Hall.f)Stapf.(Apocynaceae) are documented from this region for the first time for the treatment of malaria. These results become a basis for selection of plants for further pharmacological, toxicological and phytochemical studies in developing new plantbased antimalarial drugs.
KARURI PROFGATHUMBIPETER. "
J.M. Ngutaa, J.M. Mbaria, D.W. Gakuya, P.K. Gathumbi, S.G. Kiama Traditional antimalarial phytotherapy remedies used by the South Coast.". In:
Journal of Ethnopharmacology 131 (2010) 256. J.M. Nguta,, J.M. Mbaria, D.W. Gakuya, P.K. Gathumbi, S.G. Kiama; 2010.
AbstractAim of the study: This study was conducted to document herbal medicines used in the treatment of Malaria as well as the existing knowledge,attitudes and practices related to malaria recognition, control and treatment in South Coast, Kenya. Methods: Data was collected using semistructured questionnaires and interviews. A focused group discussion held with the community members, one in each of the study villages supplemented the interview and questionnaire survey. Results: The respondents were found to have a good understanding of malaria and could distinguish it from other fever types. They were also aware that malaria was spread by mosquitoes. Malaria prevalence was high, and affected individuals an average of four times a year. Community members avoided. Mosquito bites by using mosquitonets, clearing bushes around their homesteads and burning plant parts. To generate smoke. They prevented and treated malaria by taking decoctions or concoctions of traditional herbal remedies. Forty plant species in thirty-five genera distributed in twenty-four families were used as antimalarials in the study area. Five plant species, namely; Heeria insignis Del. (Anacardiaceae), Rottboelia exaltata L.F (Gramineae), Pentanisia ouranogyne S. Moore (Rubiaceae), Agathisanthenum globosum (A. Rich) Hiern (Rubiaceae), and Grewia trichocarpa Hochst ex A. Rich (Tiliaceae) are documented for the first time in South Coast, Kenya, for the treatment of malaria. Conclusions: The plants documented in the current study are a potential source for new bioactive compounds of therapeutic value in malaria treatment. The results provide data for further pharmacological and toxicological studies and development of commercial antimalarial phytotherapy products.
KARURI PROFGATHUMBIPETER. "
John B. Githiori and Peter K Gathumbi (2010 ) Ethnoveterinary plants used in East Africa, In: Ethnobotanical Medicines of Animals Health Taylor & Francis Group LLC Boca Raton, USA (In Press).". In:
Ethnobotanical Medicines of Animals Health Taylor & Francis Group LLC Boca Raton, USA (In Press). Muravej S, Gathece LW; 2010.
AbstractIn this study five aqueous extracts; Bidens pilosa, Strychnos henningsii, Aspilia pluriseta, Catha edulis and Erythrina abyssinica were screened for anti-diabetic activity and their in vivo safety evaluated. The anti-diabetic activity was assessed by intraperitoneally injecting varying doses of aqueous extracts of the five plants into alloxanised mice. Toxicity was determined by injecting normal mice with 450mg of the plant extract / kg body weight and observing the effects of the extracts on histology of various organs. All the extracts showed hypoglycaemic activity. At high doses, some plants proved to be highly toxic, mildly toxic and others were safe. This study has established that the five bioactive plants can be safely used in the management of diabetes.
KARURI PROFGATHUMBIPETER. "
Kibebe, H.W., Gathumbi P.K, Kigondu C.S, Mbuthia P.G, Karioki J.W. EARLY DETECTION OF HYPERGLYCEMIA USING GLYCATED HEMOGLOBIN IN MICE MODEL.". In:
THE 7TH BIENNIAL SCIENTIFIC CONFERENCE, 2010, DEPARTMENT OF PUBLIC HEALTH, PHARMACOLOGY AND TOXICOLOGY AUDITORIUM, CAVS. J.M. Nguta,, J.M. Mbaria, D.W. Gakuya, P.K. Gathumbi, S.G. Kiama; 2010.
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Experiments on animals play an important role in the study of noninfectious diseases, insulin development for diabetes treatment, kidney failure blood dialysis, transplantation techniques, and various types of surgery advancements.
In this study hyperglycemia development in mice induced with alloxan monohydrate was determined using glycated hemoglobin and compared with blood glucose.
Effective dose for making the mice hyperglycemic was first determined for alloxan monohydrate concentrations and found to be 300mg/kg body weight single dose. Ten mice were randomly selected, weighed and assigned into test and control groups (5 per group). Test group was injected with 0.2ml of 300mg/kg alloxan while control group received 0.2ml of sterile water intraperitoneally.
The blood glucose in the test group increased steadily from 3.7mmol/L (day1) to 8.4mmol/L (day 7). Glycated hemoglobin in the test group mice increased marginally from 4.75% to 5.18% compared with the control group at 4.85% to 4.90% with glucose levels stabilizing at 5%.
The experiment demonstrates that glycated hemoglobin testing can be used to detect sub-clinical diabetes mellitus and early initiation of treatment and management.