CD4 T LYMPHOCYTES SUBSET IN WOMEN WITH INVASIVE CERVICAL CANCER IN KENYA

Citation:
Gichangi P, LGATHECE, B ESTAMBALE TEMMERMANM. "CD4 T LYMPHOCYTES SUBSET IN WOMEN WITH INVASIVE CERVICAL CANCER IN KENYA." eamj. 2013;90(10):310-316.

Abstract:

ABSTRACT
Objective: Invasive cervical cancer (ICC) and HIV are common in sub-Sahara Africa.
Both ICC and HIV are immunosuppressive, and are associated with decreased CD4
and CD8 profiles. In a group of women with ICC starting radiotherapy, we determined
their CD4 profiles.
Design: This was a cross-sectional study design.
Settings: Kenyatta National Hospital, Nairobi, Kenya, radiotherapy unit.
Subjects: Women with invasive cervical cancer (344) seeking radiotherapy treatment
for the first time between January 2000 and March 2003, had blood samples analyzed
for CD4 and CD8 cell counts by flow cytometry. Haemoglobin, white cell count,
lymphocyte and platelet counts were determined using coulter machine. All patients
had received pre- and post HIV counseling.
Results: The mean age was 49+13 years. About 13.1% of the women with ICC were
HIV positive. Overall, mean and median CD4 cell count was 829+355 cells/mm3 and
792 cells/mm3. Among HIV+ patients, mean and median CD4 cell counts were 451+288
cells/mm3 and 405 cells/mm3 respectively. The mean CD4 cell count for the HIV+women was 886+329 cells/mm3 with median of 833 cells/mm3, range 147-2065 cells/mm3.
Only nine (20%) of the 45 HIV+ women had CD4 cell count of 0-200. HIV+ women
had lower CD4 percentage and cell count and higher CD8 percentage and cell count
as compared to HIV negative women, p < 0.001. HIV infection was significantly and
independently associated with high proportion of women who had CD4 cell count of
less than 200 cells/mm3 or less than 350 cells/mm3, p < 0.0001.
Conclusions: Women with ICC and concurrent HIV infection have decreased CD4 cell
subset. These results suggest HIV infection may be associated with more severe CD4
depletion in women with ICC.

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