JUMBA M.M, N.B. MIRZA, & F.B. MWAURA(1996). Agglutinins for Brucella antigens in blood sera of an urban and a rural population in Kenya E. Afri. Med.J., Vol.73, 33: 204-206

Citation:
PROF. MWAURA FRANCISB. "JUMBA M.M, N.B. MIRZA, & F.B. MWAURA(1996). Agglutinins for Brucella antigens in blood sera of an urban and a rural population in Kenya E. Afri. Med.J., Vol.73, 33: 204-206.". In: Vol. 5 April 2002 15-17. eamj; 1996.

Abstract:

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Clematis brachiata Thunberg (Ranunculaceae) is used in Kenya for the management of headaches, malaria and other febrile illnesses, abdominal disorders, yaws and for skin disorders.  Old stems and leaves are chewed for the management of toothaches and sore throats. 
Extracts of the plant were subjected to tests for antimalarial, antibacterial and antifungal activity.  The toxicity of the extracts was assessed using the brine shrimp lethality bioassay.
 
The root extract gave the highest in vitro antimalarial activity against a mulitidrug resistant strain, Plasmodium falciparum VI/S (IC50=39.24 mg/ml). The stem and leaf extracts had insignificant antiplasmodial activity.  The leaf, stem and root extracts had bacterial or fungal growth even at very high concentrations of 10 mg/ml. The LD50 values of the stem and leaf methanol extracts against the brine shrimp larvae was 365.60 and 66.5 mg/ml respectively.
The in vitro anti malarial activity of the root extract in part supports the ethnobotanical use of the plant to manage malaria.
 KEY WORDS
Clematis, Ranunculaceae, antimalarial, brine shrimp, antimicrobial

Notes:

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