.Single dose filgastrim in cytotoxic-induced neutropaenia in children.ast Afr Med J. 2008 Jan;85(1):30-5.

KHALFAN DRABDALLAHFATMAH. ".Single dose filgastrim in cytotoxic-induced neutropaenia in children.ast Afr Med J. 2008 Jan;85(1):30-5.". In: ast Afr Med J. 2008 Jan;85(1):30-5. The East and Central African Journal of Pharmaceutical Sciences.; 2008.


OBJECTIVE: To document the impact of fixed dose weight adjusted filgastrim (G-CSF) in cytotoxic-induced neutropaenia. DESIGN: A descriptive cross-sectional study. SETTING: Paediatric Oncology Unit at Kenyatta National Hospital, Nairobi, Kenya. SUBJECTS: All paediatric oncology patients who had developed cytotoxic-induced neutropaenia. MAIN OUTCOME MEASURES: The following were documented for every tissue proven case of malignancy; age, sex, type of malignancy, treatment regimen and schedule, initial blood count at the time of neutropaenia; subsequent blood counts daily for five days from day one of single dose filgastrim, and the calculated neutrophil incremental count. RESULTS: Initially eight patients with solid tumours previously treated with filgastrim revealed that cytotoxic induced neutropaenia could be ameliorated by a single dose of filgastrim. Subsequently, the study listed thirty patients. This cohort consisted of; 37% rhabdomyosarcoma, 30% Burkitts, 27% acute lymphoblastic leukaemia and 6% Hodgkin's lymphoma. Increased neutrophil count after 48 hours was documented in 26 (87%) patients, with absolute neutrophil counts range of 0.5 to 31.5 x 10(9)/L. This response was significantly influenced by gender (p>0.0001), malignancy type and chemotherapy regimen (p>0.001). CONCLUSION: The study shows that chemotherapy induced neutropaenia can be alleviated by a single dose of filgastrim without adverse effects on lymphoblastic leukaemia. This study suggests that a single dose of filgastrim should be first tried in cytotoxic induced neutropaenia in the paediatric age group. PMID: 18543524 [PubMed - in process]




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