Bio

DR. ABDALLAH FATMAH KHALFAN

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Publications


Submitted

2015

L., L, O. O, K. AF, J. G, J. N.  2015.  Risk factors for abandonement of Wilms tumor therapy in Kenya. Pediatric blood and cancer. 62(2):252-256.

2013

Abdallah, F, Axt J, Axt M, Githanga J, Hansen E, Lessan J, Li M, et al.  2013.  Wilms Tumor Survival in Kenya. National Institute of Health. 48(6)(june 2013):1254–1262.

2009

Mwanda W O, Orem J, PARSCFFK.  2009.  Dose-modified Oral Chemotherapy in the Treatment of AIDS- Related Non-Hodgkin’s Lymphoma. Journal of Clinical Oncology. 10(7641):3480-3488.

2008

KHALFAN, DRABDALLAHFATMAH.  2008.  Abdallah FK. Single dose filgastrim in cytotoxic-induced neutropaenia in children. East Afr Med J. 2008 Jan;85(1):30-5.. ast Afr Med J. 2008 Jan;85(1):30-5.. : The East and Central African Journal of Pharmaceutical Sciences. Abstract

OBJECTIVE: To document the impact of fixed dose weight adjusted filgastrim (G-CSF) in cytotoxic-induced neutropaenia. DESIGN: A descriptive cross-sectional study. SETTING: Paediatric Oncology Unit at Kenyatta National Hospital, Nairobi, Kenya. SUBJECTS: All paediatric oncology patients who had developed cytotoxic-induced neutropaenia. MAIN OUTCOME MEASURES: The following were documented for every tissue proven case of malignancy; age, sex, type of malignancy, treatment regimen and schedule, initial blood count at the time of neutropaenia; subsequent blood counts daily for five days from day one of single dose filgastrim, and the calculated neutrophil incremental count. RESULTS: Initially eight patients with solid tumours previously treated with filgastrim revealed that cytotoxic induced neutropaenia could be ameliorated by a single dose of filgastrim. Subsequently, the study listed thirty patients. This cohort consisted of; 37% rhabdomyosarcoma, 30% Burkitts, 27% acute lymphoblastic leukaemia and 6% Hodgkin's lymphoma. Increased neutrophil count after 48 hours was documented in 26 (87%) patients, with absolute neutrophil counts range of 0.5 to 31.5 x 10(9)/L. This response was significantly influenced by gender (p>0.0001), malignancy type and chemotherapy regimen (p>0.001). CONCLUSION: The study shows that chemotherapy induced neutropaenia can be alleviated by a single dose of filgastrim without adverse effects on lymphoblastic leukaemia. This study suggests that a single dose of filgastrim should be first tried in cytotoxic induced neutropaenia in the paediatric age group.

KHALFAN, DRABDALLAHFATMAH.  2008.  .Single dose filgastrim in cytotoxic-induced neutropaenia in children.ast Afr Med J. 2008 Jan;85(1):30-5.. ast Afr Med J. 2008 Jan;85(1):30-5.. : The East and Central African Journal of Pharmaceutical Sciences. Abstract

OBJECTIVE: To document the impact of fixed dose weight adjusted filgastrim (G-CSF) in cytotoxic-induced neutropaenia. DESIGN: A descriptive cross-sectional study. SETTING: Paediatric Oncology Unit at Kenyatta National Hospital, Nairobi, Kenya. SUBJECTS: All paediatric oncology patients who had developed cytotoxic-induced neutropaenia. MAIN OUTCOME MEASURES: The following were documented for every tissue proven case of malignancy; age, sex, type of malignancy, treatment regimen and schedule, initial blood count at the time of neutropaenia; subsequent blood counts daily for five days from day one of single dose filgastrim, and the calculated neutrophil incremental count. RESULTS: Initially eight patients with solid tumours previously treated with filgastrim revealed that cytotoxic induced neutropaenia could be ameliorated by a single dose of filgastrim. Subsequently, the study listed thirty patients. This cohort consisted of; 37% rhabdomyosarcoma, 30% Burkitts, 27% acute lymphoblastic leukaemia and 6% Hodgkin's lymphoma. Increased neutrophil count after 48 hours was documented in 26 (87%) patients, with absolute neutrophil counts range of 0.5 to 31.5 x 10(9)/L. This response was significantly influenced by gender (p>0.0001), malignancy type and chemotherapy regimen (p>0.001). CONCLUSION: The study shows that chemotherapy induced neutropaenia can be alleviated by a single dose of filgastrim without adverse effects on lymphoblastic leukaemia. This study suggests that a single dose of filgastrim should be first tried in cytotoxic induced neutropaenia in the paediatric age group. PMID: 18543524 [PubMed - in process]

KHALFAN, DRABDALLAHFATMAH.  2008.  Abdallah FA . EAMJ , Jan 2008 ; 85 ; 16-21. : The East and Central African Journal of Pharmaceutical Sciences. Abstract
Normal 0 false false false EN-GB X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin-top:0cm; mso-para-margin-right:0cm; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0cm; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin;} Clematis brachiata Thunberg (Ranunculaceae) is used in Kenya for the management of headaches, malaria and other febrile illnesses, abdominal disorders, yaws and for skin disorders.  Old stems and leaves are chewed for the management of toothaches and sore throats.  Extracts of the plant were subjected to tests for antimalarial, antibacterial and antifungal activity.  The toxicity of the extracts was assessed using the brine shrimp lethality bioassay.   The root extract gave the highest in vitro antimalarial activity against a mulitidrug resistant strain, Plasmodium falciparum VI/S (IC50=39.24 mg/ml). The stem and leaf extracts had insignificant antiplasmodial activity.  The leaf, stem and root extracts had bacterial or fungal growth even at very high concentrations of 10 mg/ml. The LD50 values of the stem and leaf methanol extracts against the brine shrimp larvae was 365.60 and 66.5 mg/ml respectively. The in vitro anti malarial activity of the root extract in part supports the ethnobotanical use of the plant to manage malaria.  KEY WORDS Clematis, Ranunculaceae, antimalarial, brine shrimp, antimicrobial

2006

KHALFAN, DRABDALLAHFATMAH.  2006.  Abdallah F K , Mwanda W O, . Africa Sanguine . 2006 ; 9;1;1 1-6. : The East and Central African Journal of Pharmaceutical Sciences. Abstract

OBJECTIVE: To document the impact of fixed dose weight adjusted filgastrim (G-CSF) in cytotoxic-induced neutropaenia. DESIGN: A descriptive cross-sectional study. SETTING: Paediatric Oncology Unit at Kenyatta National Hospital, Nairobi, Kenya. SUBJECTS: All paediatric oncology patients who had developed cytotoxic-induced neutropaenia. MAIN OUTCOME MEASURES: The following were documented for every tissue proven case of malignancy; age, sex, type of malignancy, treatment regimen and schedule, initial blood count at the time of neutropaenia; subsequent blood counts daily for five days from day one of single dose filgastrim, and the calculated neutrophil incremental count. RESULTS: Initially eight patients with solid tumours previously treated with filgastrim revealed that cytotoxic induced neutropaenia could be ameliorated by a single dose of filgastrim. Subsequently, the study listed thirty patients. This cohort consisted of; 37% rhabdomyosarcoma, 30% Burkitts, 27% acute lymphoblastic leukaemia and 6% Hodgkin's lymphoma. Increased neutrophil count after 48 hours was documented in 26 (87%) patients, with absolute neutrophil counts range of 0.5 to 31.5 x 10(9)/L. This response was significantly influenced by gender (p>0.0001), malignancy type and chemotherapy regimen (p>0.001). CONCLUSION: The study shows that chemotherapy induced neutropaenia can be alleviated by a single dose of filgastrim without adverse effects on lymphoblastic leukaemia. This study suggests that a single dose of filgastrim should be first tried in cytotoxic induced neutropaenia in the paediatric age group.

2005

2004

K., AF, O. MW, F. OC.  2004.  “Transfusion haemosiderosis in spite of regular use of Desferrioxiamine-Case Report”. East. Afr. Med. J.. 81:326-328.
KHALFAN, DRABDALLAHFATMAH, OTIENO PROFMWANDAWALTER, A O, M. MF.  2004.  Quality of-life in male cancer patients at Kenyatta National Hospital, Nairobi. East Afr Med J. 2004 Jul;81(7):341-7.. East Afr Med J. 2004 Jul;81(7):341-7.. : The East and Central African Journal of Pharmaceutical Sciences. Abstract

BACKGROUND: The quality of life of cancer patients is likely to be influenced by psychological reactions of the cancer patients yet there are no documented issues related to quality of life in cancer patients in Kenyan hospitals. OBJECTIVE: To investigate issues which affect the quality of life in male cancer patients. DESIGN: Prospective cross sectional study. SETTING: Kenyatta National Hospital, Nairobi, Kenya. METHODS AND SUBJECTS: Cancer patients above 12 years of age were interviewed during the course of their stay in the hospital, specifically to gather information on; semi structured questions and a modified Beck's 24 item depression inventory with a view to solicit for their reaction on issues which pertains to quality of life. MAIN OUTCOME MEASURES: Age group, level of education, tribe, geographical place (province) of birth, chief complains, main concerns, views on doctors, contact with psychiatrist and psychologist, the anatomic site of cancer, treatment given and responses on modified Beck's depression inventory. RESULTS: Forty two patients were studied, their age range 13-72 years, mean 43.2 and peak 13-26 years. Forty seven per cent of cases had no formal education. The cancers were gastrointestinal tract 33%, blood and lymphoid tissue (26%), bone and muscle (11.9%), skin (9.4%) and genitourinary tract (4.8%). Treatment given was chemotherapy, radiotherapy and surgery. Ninety three per cent were unable to cope. Chief complaints were pain, inability to work, feeling miserable and concerns were families, health and work retardation. Modified Beck's depression score was 20%, with major issues being; work retardation, insomnia, weight loss, and anorexia. Most affected were, age group 27-35 years (and least 13-26 years), uneducated, living in Nairobi (city), having carcinomas, treatment with combined surgery and radiotherapy. Low education level and residence in Nairobi coped poorly. Radiation therapy group appeared to cope better than other modalities. CONCLUSION: The issues affecting the quality of life of male cancer patients stated were pain, inability to work, poor coping with cancer and psychological reactions of work retardation, insomnia, weight loss, fatigability and depression. Gambling, suicidal ideas and social withdrawal were minimal. Other concerns were families, health and work.

2001

KHALFAN, DRABDALLAHFATMAH, KHALFAN DRABDALLAHFATMAH.  2001.  Clinical presentation and treatment outcome in children with nephroblastoma in Kenya. East Afr Med J. 2001 Jul;78(7 Suppl):S43-7.. East Afr Med J. 2001 Jul;78(7 Suppl):S43-7.. : The East and Central African Journal of Pharmaceutical Sciences. Abstract
OBJECTIVE: To review the clinical presentation and management of children with nephroplastoma and the factors influencing the outcome at Kenyatta National Referral and Teaching Hospital (KNH). DESIGN: This was a retrospective case series study based on secondary data accumulated between 1990 and 1996. SETTING: The relevant data were extracted from records of all children aged 12 years and below, admitted for cancer at KNH, Nairobi. RESULTS: Out of 803 children with cancer, 71 (8.8%) had histologically proven nephroblastoma. At presentation, 1.5% were in stage I, 13.2% stage II, 36.8% stage III, 41.2% stage IV and 7.4% stage V. Eighty five per cent presented with stage III-V disease. Ninety five per cent had nepherectomy and received chemotherapy. Radiotherapy was given to 50.7% of the patients. Nine patients died before commencement of chemotherapy, two of whom died in the immediate post-operative period. The median duration between admission and surgery was 41 days. Pre-operative chemotherapy was given to 42% of the patients. Approximately 25.5% of the patients received little or no induction chemotherapy due to unavailability of drugs while only 2.8% received the prescribed maintenance treatment with the remainder getting erratic or no treatment. Overall, only 34.7% remained disease free two years from time of diagnosis. CONCLUSION: Late presentation, poor availability of cytotoxic drugs and frequent treatment interruptions for various reasons have contributed to the poor outcome of nephroblastoma in Kenya.

2000

S., RF, P. HM, C. M, M. BS, K. AF.  2000.  . “Clinical presentation and post-mortem findings of patients with AIDS at Kenyatta National Hospital. Journal of AIDS. Supplement 24:23-29.

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