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Dr. Admani Mohamed Bashir

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Publications


2012

M. MBURU, D. WAMALWA, and WAINAINA BASHIRAL.  2012.  ASSESSMENT OF GLOMERULAR FILTRATION RATE PROFILES OF PAEDIATRIC PATIENTS ON CANCER CHEMOTHERAPY AT THE KENYATTA NATIONAL HOSPITAL, KENYA . East African Medical Journal Vol. 89 No. 6 June 2012 . Abstract

ABSTRACT
Background: An accurate estimation of renal function in children is important in optimising the dose of many drugs used in paediatric oncology for allows clinical monitoring of the nephrotoxic effects of cytotoxic agents such as cisplatin. The glomerular filtration rate (GFR) is widely accepted as the best index of renal function in patients. Chemotherapy is the mainstay of treatment in the paediatric oncology unit at the Kenyatta National Hospital.
Objectives: To determine the glomerular filtration rate profiles of paediatric oncology patients and to assess changes that had occured over a period of at least six months of continuing cancer chemotherapy.
Design: Cross-sectional hospital based survey.
Setting: General Paediatric wards, including Paediatric Oncology and Paediatric Ophthalmology ward. Kenyatta National Hospital, Nairobi, Kenya.
Subjects: Paediatric patients who had an established diagnosis of cancer and had been on chemotherapy for at least six months.
Results: Out of the 115 children enrolled in the study 43 had abnormal kidney function. This gave a prevalence of 37% (95%CI 28-46).The other 72 children had normal kidney function. Patients aged less than five years and those with solid tumors had a higher likelihood of having an abnormal GFR compared to their older counterparts and those with lymphomas and leukemias
Conclusions: Monitoring of GFR should be done regularly as decline occurs as one continues on chemotherapy especially for the ones below 5yrs and those with solid malignancies.

2010

Admani B, F. E.  2010.  Successful resuscitation of a three month old child with intralipid infusion, presumed to have bupivacaine induced seizures and cardiovascular complications: case report.. East Afr Med J. 2010 Aug;87(8):354-6.. Abstract

Abstract
Anaesthetic agents used locally can be toxic especially if given as an inappropriate dose or route. Lipid infusion has been demonstrated in several animal models to successfully resuscitate bupivacaine induced toxicity. We present a case of successful use of 26% lipid infusion to resuscitate a paediatric patient with a presumed subcutaneous injection of bupivacaine and lignocaine which led to neurological and cardiologic consequences.

2008

Admani B, Macharia WM, WF.  2008.  Seroprevalence of varicella zoster antibodies among children with malnutrition, malignancies and HIV infection.. East Afr Med J. 2008 Oct;85(10):480-6.. Abstract

Abstract
OBJECTIVE:
To determine the seroprevalence of varicella zoster in paediatric patients at a high risk of developing complications.
DESIGN:
A cross-sectional study.
SETTING:
Paediatric general wards at Kenyatta National Hospital.
SUBJECTS:
Children with malignancies, severe malnutrition and were HIV positive.
INTERVENTIONS:
The sample size was calculated at 147 subjects. Venous samples were tested for varicella zoster virus (VZV) antibodies using enzyme immunosorbent assay (ELISA) technique at Kenya Medical Research Institute (KEMRI) laboratories, The data were analysed using the SPSS software and presented in form of tables and graphs. The prevalence of VZV antibodies was determined and 95% confidence interval computed.
RESULTS:
The overall seroprevalence of VZV antibodies in the three groups of children studied was 23.6% (95% CI = 17.4, 29.8). The seroprevalence of VZV antibodies in those with malignancies and severe malnutrition was 24.1 and 25.0% respectively. About 22% of HIV positive children had protective levels of VZV antibodies. Though the seroprevalence increased with age, it was not significantly associated with area of residence, size of residence, family size or income.
CONCLUSIONS:
The low prevalence of protective VZV antibodies among children with severe malnutrition, malignancies and HIV infection children at Kenyatta National Hospital warrants routine immunisation of the high-risk population

Berry CJ, Johnson FL, Cabuay BM, Chase J SAHBG-GSMWRMA, Stolpen AH, Bashir A, Gabriel-Griggs SM WRM.  2008.  Images in cardiovascular medicine. Evanescent asymmetrical septal hypertrophy and rapidly progressive heart failure in a 32-year-old man.. Circulation. 2008 Aug 19;118(8):e126-8. doi: 10.1161/CIRCULATIONAHA.108.769000..

2003

Bashir AA, RRA, Benda JA SRB.  2003.  Sinonasal adenocarcinoma: immunohistochemical marking and expression of oncoproteins.. Head Neck. 2003 Sep;25(9):763-71.. Abstract

Abstract
BACKGROUND:
Relatively little is known concerning the immunohistochemical marking of sinonasal
adenocarcinoma (SNA). The most clinically problematic tumors are those that seem
histologically identical to colonic adenocarcinoma, a neoplasm that may metastasize to the
sinonasal region. To determine whether differentiated immunohistochemical expression of
keratins could differentiate primary from metastatic tumors and to understand the biology of
these tumors, differentiated keratin and oncoprotein expression was investigated.
METHODS:
Eleven patients with sinonasal adenocarcinoma were investigated for expression of cytokeratins
7 and 20 (CK7, CK20), AE 1/3, CAM 5.2, smooth muscle-specific actin, muscle-specific actin,
desmin, S-100, carcinoembryonic antigen (CEA), p53, and HER-2/neu.
RESULTS:
All sinonasal adenocarcinomas of intestinal type were cytokeratin 7 positive. None of the tumors
showed myoepithelial differentiation. Strong HER-2/neu staining was seen in some tumors.
CONCLUSIONS:
Strong HER-2/neu staining in some cases suggests this oncogene may be involved in the genesis
of SNA. Immunohistochemical staining with cytokeratin 7 may be potentially useful in
differentiating primary from metastatic disease in sinonasal adenocarcinomas of the intestinal
subtype.
Copyright 2003 Wiley Periodicals, Inc. Head Neck 25: 763-771, 2003

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