Sinonasal adenocarcinoma: immunohistochemical marking and expression of oncoproteins..
Head Neck. 2003 Sep;25(9):763-71.. Abstract
Relatively little is known concerning the immunohistochemical marking of sinonasal
adenocarcinoma (SNA). The most clinically problematic tumors are those that seem
histologically identical to colonic adenocarcinoma, a neoplasm that may metastasize to the
sinonasal region. To determine whether differentiated immunohistochemical expression of
keratins could differentiate primary from metastatic tumors and to understand the biology of
these tumors, differentiated keratin and oncoprotein expression was investigated.
Eleven patients with sinonasal adenocarcinoma were investigated for expression of cytokeratins
7 and 20 (CK7, CK20), AE 1/3, CAM 5.2, smooth muscle-specific actin, muscle-specific actin,
desmin, S-100, carcinoembryonic antigen (CEA), p53, and HER-2/neu.
All sinonasal adenocarcinomas of intestinal type were cytokeratin 7 positive. None of the tumors
showed myoepithelial differentiation. Strong HER-2/neu staining was seen in some tumors.
Strong HER-2/neu staining in some cases suggests this oncogene may be involved in the genesis
of SNA. Immunohistochemical staining with cytokeratin 7 may be potentially useful in
differentiating primary from metastatic disease in sinonasal adenocarcinomas of the intestinal
Copyright 2003 Wiley Periodicals, Inc. Head Neck 25: 763-771, 2003