F. A. Okalebo, A. N. Guantai, C. K. Maitai, I. O. Kibwage. Pharmacological screening of extracts of Clematis brachiata Thunberg (Ranunculaceae). East African Journal of Botany. 2 (1): 279

Citation:
APOLOT DROKALEBOFAITH. "F. A. Okalebo, A. N. Guantai, C. K. Maitai, I. O. Kibwage. Pharmacological screening of extracts of Clematis brachiata Thunberg (Ranunculaceae). East African Journal of Botany. 2 (1): 279 .". In: East African Journal of Botany. 2 (1): 279 . East Afri. J. Botany; 2010.

Abstract:

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The leaves and old stems of Cletmatis brachiata Thunberg (Ranunculaceae) are chewed in Kenya for the management of toothache and sore throat. An infusion of the leaf is drunk for the management of headaches and abdominal disorders.  The study was done to determine the scientific rationale for the use of the plant as an analgesic and for the management of abdominal disorders.  Extracts of the plant were subjected to the hot plate and tail pressure tests for antinociceptive activity and guinea pig wheal test for local anesthetic activity.  The effects of the extracts on the isolated rabbit jejunum were also studied.  The extracts of the leaf and stem were found to have significant local anesthetic and antinociceptive activity. The extracts had spasmolytic effects on the isolated rabbit jejunum.  These findings support the traditional uses of the plant which could be subjected to bioactivity guided isolation for analgesic, local anaesthetic and spasmolytic compounds. 
Key words: Clematis; Ranunculaceae; plant extracts; antinociceptive; local anesthesia; spasmolytic

Notes:

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