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Conference Paper
Njagi LW;, Mbuthia PG;, Nyaga PN;, Bebora LC;, Michieka JN;, Minga UM. "Localisation Of Newcastle Disease Viral Nucleoprotein In The Tissues Of Carrier Ducks.".; 2008. Abstract

Localisation of Newcastle disease viral nucleo protein in the tissues of carrier ducks was evaluated in 45 experimentally infected and 10 sentinel ducks. Ten chickens were used as positive control bir ds. The ducks were sacrificed serially on days 1, 4, 8 and 14 – post - inoculation. Six tissues (liver, spleen, lung, cecal tonsils, kidneys and brain) were collected from each bird, preserved in 10% neutral formalin for 24 hours, and then transferred to 70% ethanol. Indirect alkaline phosphatase – antialkaline phosphatase immunoperoxidase staining was performed to detect viral nucleoprotein. The ducks (28.9 %) had Newcastle disease viral nucleoprotein in their tissues. The viral nucleoprotein s were found in l arge mononuclear cells of cecal tonsils and tubular epithelial cells in the kidneys of infected ducks. The viral antigens were located in the cytoplasm and nucleolus of the respective cells. Liver, lungs, spleen and brain of all infected ducks did not have detectable viral antigens. The number of ducks with viral antigen increased with duration of infection from 22.2%, 16.7%, 33.3% and 41.7% on days 1, 4, 8 and 14 post - inoculation , respectively (p<0.05).Viral antigen intensity in cecal tonsil tissue section s was 4, 5, and > 5 cells in 15.4%, 53.8% and 30.8%, respectively, of the infected ducks. In the kidneys, more than 5 positive cells were recorded. Thus, in Newcastle disease virus carrier ducks, the kidneys and cecal tonsils need to be sampled for virus i solation besides other tissues.

Njagi LW;, Mbuthia PG;, Nyaga PN;, Bebora LC;, Michieka JN;, Minga UM. "Localisation Of Newcastle Disease Viral Nucleoprotein In The Tissues Of Carrier Ducks.".; 2008. Abstract

Localisation of Newcastle disease viral nucleo protein in the tissues of carrier ducks was evaluated in 45 experimentally infected and 10 sentinel ducks. Ten chickens were used as positive control bir ds. The ducks were sacrificed serially on days 1, 4, 8 and 14 – post - inoculation. Six tissues (liver, spleen, lung, cecal tonsils, kidneys and brain) were collected from each bird, preserved in 10% neutral formalin for 24 hours, and then transferred to 70% ethanol. Indirect alkaline phosphatase – antialkaline phosphatase immunoperoxidase staining was performed to detect viral nucleoprotein. The ducks (28.9 %) had Newcastle disease viral nucleoprotein in their tissues. The viral nucleoprotein s were found in l arge mononuclear cells of cecal tonsils and tubular epithelial cells in the kidneys of infected ducks. The viral antigens were located in the cytoplasm and nucleolus of the respective cells. Liver, lungs, spleen and brain of all infected ducks did not have detectable viral antigens. The number of ducks with viral antigen increased with duration of infection from 22.2%, 16.7%, 33.3% and 41.7% on days 1, 4, 8 and 14 post - inoculation , respectively (p<0.05).Viral antigen intensity in cecal tonsil tissue section s was 4, 5, and > 5 cells in 15.4%, 53.8% and 30.8%, respectively, of the infected ducks. In the kidneys, more than 5 positive cells were recorded. Thus, in Newcastle disease virus carrier ducks, the kidneys and cecal tonsils need to be sampled for virus i solation besides other tissues

CAROLINE MUTAI. "L." KENYATTA UNIVERSITY; 2008. Abstract
n/a
WANJIRU MRSKARIUKILUCY, KINYUA DRNGUUEDWARD, W. DRKINYANJUIPETER, BULIMO DRDIMBUSONWALLACE. "L.W. Kariuki, E.K. Nguu, R.M. Njogu, P. W. Kinyanjui, J.O.Midiwo, W.D. Bulimo, J.K.Kiaira. MAESANIN: A BENZOQUINONE FROM MAESA LANCEOLATA THAT COMPLETELY INHIBITS RESPIRATION IN BLOODSTREAM TRYPANOSOMA BRUCEI BRUCEI.". In: 5th International Congress of the African Association of Physiological Sciences (AAPS). Kisipan, M.L.; 2008.
WANJIRU MRSKARIUKILUCY, KINYUA DRNGUUEDWARD, W. DRKINYANJUIPETER, BULIMO DRDIMBUSONWALLACE. "L.W. Kariuki, E.K. Nguu, R.M. Njogu, P. W. Kinyanjui, J.O.Midiwo, W.D. Bulimo, J.K.Kiaira. MAESANIN: A BENZOQUINONE FROM MAESA LANCEOLATA THAT COMPLETELY INHIBITS RESPIRATION IN BLOODSTREAM TRYPANOSOMA BRUCEI BRUCEI.". In: 5th International Congress of the African Association of Physiological Sciences (AAPS). ELSAYED EL BANHAWY,1 L. IRUNGU1 & H. MUGO2; 2008.
WANJIRU MRSKARIUKILUCY, KINYUA DRNGUUEDWARD, W. DRKINYANJUIPETER, BULIMO DRDIMBUSONWALLACE. "L.W. Kariuki, E.K. Nguu, R.M. Njogu, P. W. Kinyanjui, J.O.Midiwo, W.D. Bulimo, J.K.Kiaira. MAESANIN: A BENZOQUINONE FROM MAESA LANCEOLATA THAT COMPLETELY INHIBITS RESPIRATION IN BLOODSTREAM TRYPANOSOMA BRUCEI BRUCEI.". In: 5th International Congress of the African Association of Physiological Sciences (AAPS). MBA; 2008.
WANJIRU MRSKARIUKILUCY, KINYUA DRNGUUEDWARD, W. DRKINYANJUIPETER, BULIMO DRDIMBUSONWALLACE. "L.W. Kariuki, E.K. Nguu, R.M. Njogu, P. W. Kinyanjui, J.O.Midiwo, W.D. Bulimo, J.K.Kiaira. MAESANIN: A BENZOQUINONE FROM MAESA LANCEOLATA THAT COMPLETELY INHIBITS RESPIRATION IN BLOODSTREAM TRYPANOSOMA BRUCEI BRUCEI.". In: 5th International Congress of the African Association of Physiological Sciences (AAPS). Heinrich Boll Foundation.; 2008.
ORIARE MRMBEKEPETER. "Law Regulation and Politics in Kenya since 2002.". In: BBC World Service Trust Policy Brief No. 1. BBC World Service Trust; 2008. Abstract
The paper discusses the impact of legal and regulation framework on mass media in Kenya. It argues that weak, irresolute and inadequate legal, regulatory and policy framework inherited from the colonial administration and perpetuated by the Kenyatta, Moi and Kibaki regimes have undermined the role of media in politics.
W. PROFJAOKOGODFREY. "Lester RT, Yao XD, Ball TB, McKinnon LR, Kaul R, Wachihi C, Jaoko W, Plummer FA, Rosenthal KL.Toll-like receptor expression and responsiveness are increased in viraemic HIV-1 infection.AIDS. 2008 Mar 30;22(6):685-94.". In: AIDS. 2008 Mar 30;22(6):685-94. AIDS 24(6):891-7; 2008. Abstract
OBJECTIVES: Toll-like receptors (TLR) are important in pathogen recognition and may play a role in HIV disease. We evaluated the effect of chronic untreated and treated HIV-1 infection on systemic TLR expression and TLR signalling. METHODS: Two hundred HIV-infected and uninfected women from a Kenya cohort participated in the studies. TLR1 to TLR10 messenger RNA expression was determined by quantitative reverse transcriptase polymerase chain reaction in peripheral blood mononuclear cells (PBMC). TLR ligand responsiveness was determined in or using ex-vivo PBMC by cytokine production in culture supernatants. RESULTS: Chronic, untreated HIV-1 infection was significantly associated with increased mRNA expression of TLR6, TLR7, and TLR8 and when analysis was limited to those with advanced disease (CD4 cell count < 200 cells/ml) TLR2, TLR3, and TLR4 were additionally elevated. TLR expression correlated with the plasma HIV-RNA load, which was significant for TLR6 and TLR7. In vitro HIV single-stranded RNA alone could enhance TLR mRNA expression. PBMC of HIV-infected subjects also demonstrated profoundly increased proinflammatory responsiveness to TLR ligands, suggesting sensitization of TLR signalling in HIV. Finally, viral suppression by HAART was associated with a normalization of TLR levels. CONCLUSION: Together, these data indicate that chronic viraemic HIV-1 is associated with increased TLR expression and responsiveness, which may perpetuate innate immune dysfunction and activation that underlies HIV pathogenesis, and thus reveal potential new targets for therapy.
S. PROFAKUNDABWENILEVI. "Levi-Shadeya M Akundabweni, et. al,- 2008. Screening and Mapping Nutraceutical Dense Biodiversity on Women Smallholder Farms Based on Farmer.". In: International Society for Horticultural Science; Leuven, Belgium. 739 pp. African Scholarly Science Communications Trust; 2008.
MUHIA DRLILLIANWANGECHIWAIBOCI. "Lilian Waiboci- Muhia, Howard M. Johnson SUPPRESSOR OF CYTOKINE SIGNALING-1 MIMETIC AND ANTAGONIST PEPTIDES: POTENTIAL AS THERAPEUTIC AGENTS .". In: 5th International Congress of the African Association of Physiological Sciences (AAPS). Ahmed C.M., Dabelic R., Waiboci L., Jager L.D., Heron L.L. and Johnson H.M.; 2008.
MBURU MRSTEPHENNGANGA. "Longhorn Gateway Computer Studies Series Revision Guide.". In: European Journal of Pharmaceutical sciences. Longhorn; 2008.
DR. LUKHOBA CATHERINEW. "Lukhoba, C and Siboe G., 2008. Ethnobotanical data in the search and identification of drug plants. East and Central African Journal of Pharmaceutical Sciences. 11: 43-48.". In: East and Central African Journal of Pharmaceutical Sciences.; 2008. Abstract
Traditional medicine has utilized plants to palliate, cure and/or prevent diseases in both humans and animals. The acquisition of knowledge has been through trial and error, and observation. Today, the enhanced search for botanical drugs throughout the world has increased the need for accurate means of identifying plants with possible pharmacological and biological activity. A number of methodologies have been used in selecting plants likely to possess pharmacological properties, but many have recorded low success rates. Data reported in this paper reveal that the accuracy of identification of these herbal drugs for pertinent ailments using ethnobotanical data is almost as accurate as techniques applied in modern medical practice. This paper discusses the value of ethno-botanical data in the preliminary search for potential drug plants Key words: Ocimum, Plectranthus, ethnobotany, medicinal plants.
Atieno R. "The Limits of Policy Success: The Case of the Dairy Sector in Kenya.". In: workshop for the World Development Report, by the Future Agricultures Consortium at the IDS, Sussex, UK. IDS, Sussex, UK; 2007.
Kipkemoi TP;, Wambugu SN;, Joakim D;, Kiama SG;, Kanui TI. "Laboratory management of captive hingeback tortoises."; 2007.
Kipkemoi TP;, Wambugu SN;, Joakim D;, Kiama SG;, Kanui TI. "Laboratory management of captive hingeback tortoises."; 2007.
Kipkemoi TP;, Wambugu SN;, Joakim D;, Kiama SG;, Kanui TI. "Laboratory management of captive hingeback tortoises."; 2007.
O PROFBWIBONIMROD. "Low plasma vitamin B-12 in Kenyan school children is highly prevalent and improved by supplemental animal source foods. J Nutr . 2007 Mar; 137 ( 3 ): 676-82 . PMID: 17311959 [PubMed - indexed for MEDLINE] McLean ED, Allen LH, Neumann CG, Peerson JM, Siekm.". In: J Nutr . 2007 Mar; 137 ( 3 ): 676-82 . Anim. Hlth. Prod. Afr. 2008; 2007. Abstractlow_plasma_vitamin_b-12.pdf

Department of Nutritional Biology, University of California, Davis, CA 95616, USA.

The high prevalence of vitamin B-12 deficiency in many regions of the world is becoming recognized as a widespread public health problem, but it is not known to what extent this deficiency results from a low intake of the vitamin or from its malabsorption from food. In rural Kenya, where a previous study identified a high prevalence of inadequate vitamin B-12 intakes, this study examined whether plasma vitamin B-12 concentrations were associated with dietary sources of the vitamin at baseline and could be increased by supplementation with animal source foods (ASF). The 4 experimental groups in 503 school children were: 1) control (no food provided); 2) githeri (a maize and bean staple with added oil); 3) githeri + meat (githeri + minced beef); or 4) githeri + milk (githeri + milk). Feedings were isocaloric. Dietary data were collected at baseline, and biochemical data at baseline and after 1 and 2 y of feeding. Baseline plasma vitamin B-12 concentration was 193.6 +/- 105.3 pmol/L and correlated with % energy from ASF (r = 0.308, P < 0.001). The odds ratio for low plasma vitamin B-12 (<148 pmol/L), which occurred in 40% of children, was 6.28 [95% CI: 3.07-12.82] for the lowest vs. highest ASF intake tertile (P < 0.001). Feeding ASF (meat or milk) greatly reduced the prevalence of low plasma vitamin B-12 (P < 0.001). The high prevalence of low plasma vitamin B-12 concentrations in these children is predicted by a low intake of ASF, and supplemental ASF improves vitamin B-12 status.

PMID: 17311959 [PubMed - indexed for MEDLINE]

Ating’a JEO, KO A. "Lower limb amputations at the Kenyatta National Hospital, Nairobi. East Afr Med J. 2007 Mar;84(3):121-6.". In: Occasional Publication Number 3 2003. pp 21-32. E Afr Med J; 2007. Abstract

OBJECTIVE: To determine the causes and pattern of lower limb amputations at the Kenyatta National Hospital. DESIGN: Descriptive prospective study. SETTING: The Kenyatta National Hospital between July 2003 and June 2004. RESULTS: A total of 77 lower limb amputations (LLA) were performed on 74 patients. The age ranged from seven months to 96 years (mean 44.8 +/- 22.5). Forty six patients (62.1%) were male. Majority of the patients (89.1%) had primary or no formal education, forty one (55.4%) were unemployed, with 39% self employed in the informal sector. Peripheral vascular diseases were the main indication for LLA (55.3%), 13 patients (17.5%) due to diabetes-related gangrene. Eighteen patients (24.3%) had tumours, mainly osteogenic sarcoma (16.2%), while trauma accounted for 18.9%. Forty two (55%) of the amputations were above-the-knee, 24 (31%) below-the-knee, four (5%) hip disarticulations and seven (9%) were foot amputations. CONCLUSION: This study found peripheral vascular diseases unrelated to diabetes to be the main indication for lower limb amputations at Kenyatta National Hospital contrary to previous institutional and loco-regional studies which report trauma as the leading cause. Further investigation into vascular causes is therefore recommended.

CHEGE MRMUNGAIJOSEPH. "Labour And Industrial Relations (Course Unit) Dept. Of Extra Mural Studies, Nairobi.". In: Bristol University, UK, September 1989. University of Nairobi; 2007. Abstract
Seventeen cows of various breeds with varying degrees of severity of advanced ocular squamous cell carcinoma were treated by radical surgery, which included enucleation and extirpation of the surrounding ocular muscles and tissues. The degree of severity and the extent of the carcinoma lesion was correlated with the outcome of treatment for each case. It was observed that: 1. eyeball involvement, 2. ulceration and subsequent infection of carcinoma lesion involving the eyelids and 3. involvement of the regional lymphnodes especially the parotid , are some of the main factors that could be used to draw prognosis of such cases. Although the initial surgery may not be costly, the overall cost of managing postoperative complications is prohibitive and results to vast economic losses that should not be ignored.
A PROFOMWANDHOCHARLESO. "Langat DK, Morales PJ, Omwandho CO, Fazleabas AT. Polymorphisms in the Paan-AG promoter influence NF-kappaB binding and transcriptional activity.". In: Immunogenetics. 2007 May;59(5):359-66.; 2007. Abstract

The human leukocyte antigen-G (HLA-G) gene encodes a protein that is highly expressed at the human maternal-fetal interface during pregnancy and may be critical to the survival of the semiallogenic fetus. A unique feature of this gene is a 13-bp deletion in the proximal promoter that renders it unresponsive to transactivation by the nuclear factor-kappaB (NF-kappaB). We previously showed that the proximal promoter of Paan-AG, the functional homologue of HLA-G in the olive baboon (Papio anubis), is intact. We cloned the promoters of two putative Paan-AG alleles (AG1 and AG2) and identified a number of regulatory elements including two kappaB sites. In the current study, binding and activity of the two kappaB elements in each putative allele were assessed by electrophoretic mobility shift and supershift assays. Functional activity was determined using luciferase reporter assays. The kappaB1 and kappaB2 elements in AG1 bound NF-kappaB with similar affinity. In contrast, the kappaB1 element of AG2 bound NF-kappaB with a much higher affinity than AG-1 kappaB1 (a 30-fold increase), whereas kappaB2 did not bind. Mutagenesis analysis showed that the difference in binding intensities was due to two nucleotides in the 3' end of kappaB1. Similarly, failure of AG2 kappaB2 binding was a result of the last nucleotide in the 3' end that differed from the consensus; mutating this nucleotide to match the consensus reestablished binding. Functional activity of the two putative alleles also differed; AG1 luciferase activity was consistently lower than that of AG2. Mutating the last two nucleotides in the 3' end of AG1 kappaB1 resulted in increased luciferase activity to levels comparable to that of AG2. Overall, these results show that in vitro variations in the promoter region may influence transcription of Paan-AG.

R. MRMUINAMIAKENNEDY. "A Latex Agglutination Test for Capripoxvirus K Muinamia, Y S Binepal, J Machuka, J Makumi, R Soi.". In: Journal of Tropical Microbiology and Biotechnology. ISSN: 1607-4106. Plant Molecular Biology Reporter Vol. 27, pp. 79-85.; 2007. Abstract
The gene Q13L coding for the Capripoxvirus group specific structural protein P32 was expressed in Escherichia coli using plasmid pGEX-2T as a fusion protein with glutathione-s-transferase and purified on glutathione sepharose affinity chromatography column. The protein was then employed for diagnosis of sheeppox, goatpox and lumpyskin disease, by a latex agglutination test (LAT) using the purified P32 antigen and guinea pig detector antiserum raised against the P32 antigen. The LAT and virus neutralization test (VNT) were used to screen one hundred livestock field sera for antibodies to Capripoxvirus, in comparison the LAT was simpler, rapid and 23% more sensitive than the VNT. In addition the LAT was found to be specific for Carpripoxvirus because it did not pick antibodies to Orthopoxvirus and Parapoxvirus. The LA test can be taken for a simple and quick diagnostic tool for primary screening of Carpripoxvirus infection and will reduce the reliance of diagnostic laboratories on tissue culture facilities. Keywords: Carpripox, latex agglutination test, attachment gene J. Trop. Microbiol. Biotechnol. Vol. 3 (2) 2007: pp. 36-43
O. PROFWEKEPATRICKGUGE. "Linear Estimation of Scale Parameter for Logistic Distribution Based on Consecutive Order Statistics.". In: Sankhya: The Indian Journal of Statistics Vol. 69 Part 4, pages 870 . Sankhya: The Indian Journal of Statistics; 2007. Abstract
Historia ya maisha binafsi kutoka kwale
MBORI- PROFNGACHADOROTHYA. "Longitudinal comparison of chemokines in breastmilk early postpartum among HIV-1-infected and uninfected Kenyan women. Breastfeed Med . 2007 Sep; 2 ( 3 ): 129-38 . PMID: 17903098 [PubMed - indexed for MEDLINE] Bosire R, Guthrie BL, Lohman-Payne B, Mabuka .". In: Breastfeed Med . 2007 Sep; 2 ( 3 ): 129-38 . Earthscan, London. 978-1-84407-469-3 (*); 2007. Abstract
Center for Public Health Research, Kenya Medical Research Institute, Nairobi, Kenya. Breastmilk chemokines have been associated with increased HIV-1 RNA levels in breastmilk and altered risk of mother-to-child HIV-1 transmission. To characterize CC and CXC chemokines in breastmilk postpartum, we collected breastmilk specimens at regular intervals for 6 months after delivery from women with and without HIV-1 infection and used commercial ELISA kits to measure breastmilk concentrations of MIP-1alpha, MIP-1beta, RANTES, and SDF-1alpha. Among 54 HIV-1-infected and 26 uninfected women, mean chemokine levels were compared cross-sectionally and longitudinally at days 5 and 10, and months 1 and 3 postpartum. For both HIV-1-infected and uninfected women, breastmilk chemokine levels were highest at day 5 for MIP-1alpha, MIP-1beta, and SDF-1alpha, and subsequently decreased. RANTES levels remained constant over the follow-up period among HIV-1-uninfected women, and increased moderately among HIV-1-infected women. For MIP-1beta and RANTES, breastmilk levels were significantly higher among HIV-1-infected women compared to uninfected women early postpartum. In addition, HIV-1-infected women transmitting HIV-1 to their infant had consistently higher breastmilk RANTES levels than those who did not transmit, with the greatest difference observed at 1 month (2.68 vs. 2.21 log10 pg/mL, respectively; p = 0.007). In summary, all four chemokines were most elevated within the first month postpartum, a period of high transmission risk via breastmilk. MIP-1beta and RANTES levels in breastmilk were higher among HIV-1-infected women than among uninfected women, and breastmilk RANTES was positively associated with vertical transmission in this study, consistent with results from our earlier cohort. PMID: 17903098 [PubMed - indexed for MEDLINE]
Kiamba A. "Leadership and Governance in Africa.". In: Enhancement of the Study of international Relations in Africa. Nairobi; 2006.
Mbaria JM, Ambala PA. "Levels of Aflatoxins in maize samples collected from Makueni District, Kenya, during an outbreak of acute aflatoxicosis in humans. .". In: Faculty of veterinary medicine biennial scientific conference. Faculty of veterinary medicine ; 2006.
MUNYAO ML. "L.M. Mulwa, "Meeting the Challenge of Managing Quality for E-Service Organizations", A paper presented in The third ORSEA Conference held at Entebbe." EM Ngatia, LW Gathece, FG Macigo, TK Mulli, LN Mutara, EG Wagaiyu.; 2006. Abstract

Department of Periodontology/ Community and Preventive Dentistry, School of Dental Sciences, University of Nairobi, P.O. Box 19676 - 00202, Nairobi, Kenya. OBJECTIVE: To determine the influence of oral hygiene habits and practices on the risk of developing oral leukoplakia. DESIGN: Case control study. SETTING: Githongo sublocation in Meru District. SUBJECTS: Eighty five cases and 141 controls identified in a house-to-house screening. RESULTS: The relative risk (RR) of oral leukoplakia increased gradually across the various brushing frequencies from the reference RR of 1.0 in those who brushed three times a day, to 7.6 in the "don't brush" group. The trend of increase was statistically significant (X2 for Trend : p = 0.001). The use of chewing stick as compared to conventional tooth brush had no significant influence on RR of oral leukoplakia. Non-users of toothpastes had a significantly higher risk of oral leukoplakia than users (RR = 1.8; 95% confidence levels (CI) = 1.4-2.5). Among tobacco smokers, the RR increased from 4.6 in those who brushed to 7.3 in those who did not brush. Among non-smokers, the RR of oral leukoplakia in those who did not brush (1.8) compared to those who brushed was also statistically significant (95% CL = 1.6-3.8). CONCLUSION: Failure to brush teeth and none use of toothpastes are significantly associated with the development of oral leukoplakia, while the choice of brushing tools between conventional toothbrush and chewing stick is not. In addition, failure to brush teeth appeared to potentiate the effect of smoking tobacco in the development of oral leukoplakia. Recommendations: Oral health education, instruction and motivation for the improvement of oral hygiene habits and practices; and therefore oral hygiene status, should be among the strategies used in oral leukoplakia preventive and control programmes.

O. PROFNDINYA-ACHOLAJ. "Lavreys L, Baeten JM, Chohan V, McClelland RS, Richardson BA, Mandaliya K, Ndinya-Achola J, Overbaugh J. Higher set point plasma viral load and more severe acute HIV-1 illness predict mortality among high-risk HIV-1 infected African women.Clin Infect Dis.". In: Clin Infect Dis. 2006 May 1;42(9):1333-9. Epub 2006 Mar 27. IBIMA Publishing; 2006. Abstracthigher_set_point_plasma_viral_load.dochigher_set_point_plasma_viral_load.pdf

BACKGROUND: There is limited information on the natural history of human immunodeficiency virus type 1 (HIV-1) infection in Africa, especially from individuals with well-defined dates of infection. We used data from a prospective cohort study of female sex workers in Mombasa, Kenya, who were followed up monthly from before the date of HIV-1 infection. METHODS: Antiretroviral-naive women who had a well-defined date of HIV-1 infection were included in this analysis. The effects of set point plasma viral load (measured 4-24 months after infection), early CD4+ cell count, and symptoms of acute HIV-1 infection on mortality were assessed using Cox proportional hazards analysis. RESULTS: Among 218 women, the median duration of follow-up after HIV-1 infection was 4.6 years. Forty women died, and at 8.7 years (the time of the last death), the cumulative survival rate was 51% by Kaplan-Meier analysis. Higher set point viral load, lower early CD4+ cell count, and more-symptomatic acute HIV-1 illness each predicted death. In multivariate analysis, set point viral load (hazard ratio [HR], 2.28 per 1 log10 copies/mL increase; P=.001) and acute HIV-1 illness (HR, 1.14 per each additional symptom; P=.05) were independently associated with higher mortality. CONCLUSION: Among this group of African women, the survival rate was similar to that for HIV-1-infected individuals in industrialized nations before the introduction of combination antiretroviral therapy. Higher set point viral load and more-severe acute HIV-1 illness predicted faster progression to death. Early identification of individuals at risk for rapid disease progression may allow closer clinical monitoring, including timely initiation of antiretroviral treatment.

O. PROFNDINYA-ACHOLAJ. "Lavreys L, Baeten JM, Panteleeff D, Richardson BA, McClelland RS, Chohan V, Mandaliya K, Ndinya-Achola J, Overbaugh J. High levels of cervical HIV-1 RNA during early HIV-1 infection.". In: AIDS 2006; 20:2389-90. IBIMA Publishing; 2006. Abstracthigh_levels_of_cervical_hiv-1_rna.dochigh_levels_of_cervical_hiv-1_rna.pdf

{ BACKGROUND: Low serum selenium has been associated with lower CD4 counts and greater mortality among HIV-1-seropositive individuals, but most studies have not controlled for serum albumin and the presence of an acute phase response. METHODS: A cross-sectional study was conducted to evaluate relationships between serum selenium concentrations and CD4 count, plasma viral load, serum albumin, and acute phase response markers among 400 HIV-1-seropositive women. RESULTS: In univariate analyses, lower CD4 count, higher plasma viral load, lower albumin, and the presence of an acute phase response were each significantly associated with lower serum selenium concentrations. In multivariate analyses including all four of these covariates, only albumin remained significantly associated with serum selenium. For each 0.1 g/dl increase in serum albumin, serum selenium increased by 0.8 microg/l (p < 0.001). Women with an acute phase response also had lower serum selenium (by 5.6 microg/l

Abala D. "Lecture Series: Introduction to Microeconomics, University of Nairobi Press.". In: Eastern Africa Economic Review.; 2006.
Guthiga P;, Mburu J. "Local Communities Incentives for Forest Conservation: Case of Kakamega Forest in Kenya."; 2006. Abstract

"The study is based on a biodiversity-rich remnant of a tropical rainforest located in western Kenya under immense threat of survival. The forest is located in a densely populated area inhabited by poor farming communities. Currently the forest is managed by three management regimes each carrying out its function in a different manner. The study identifies, describes and where possible quantifies the various conservation incentives (both economic and non-economic) offered by the three management regimes. Further, the study analyses local people's perception of management regimes by generating management satisfaction rankings; both overall and for specific management aspects. The findings of the study indicate that extraction of direct forest products is the main incentive offered by two of the regimes. The local people obtain substantial financial benefits in the form of products they extract from the forest. Satisfaction ranking showed that the strictest regime among the three was ranked highest overall for it performance. Coincidentally, the highest ranked regime has the best performance among the three in conserving the forest in its pristine state. An ordered logit regression was used to analyse factors influencing the overall satisfaction ranking. The results indicate that socio-economic factors are not significant in explaining the level of satisfaction ranking but involvement in forest conservation activities appears important in explaining satisfaction ranking. The paper concludes by highlighting some policy implications of the results."

Guthiga P;, Mburu J;, Holm-Muller K. "Local Communities’ Perceptions Towards Forest Management Regimes: Case of Kakamega Forest in Kenya."; 2006. Abstract

Kakamega Forest is located in western Kenya and covers approximately 240 Km2. The forest is the only lowland tropical rainforest in Kenya and it is world famous for its diversity of unique and numerous flora and fauna. However its survival is under immense threat since it is located in a densely populated area where local communities depend heavily on agriculture and forest extraction for their livelihoods. Currently, the forest is divided into three different parts that are managed through three distinct management approaches: an incentive-based approach of the Forest department (FD), a protectionist approach of the Kenya Wildlife Service (KWS) and a quasi private- approach of a local church mission, the Quakers. A review of literature clearly indicates that forest management regimes of public forests are important in assigning property rights to the various stakeholders and guiding use and consequently the outcomes. On the same footing research has pointed out the centrality of the local communities in the process of natural resource management. The persistence of resource degradation problems and failure of technical simple technical or economic prescription clearly indicates that there is need to consider the more complex aspects of natural resource management. The perception of the local people towards management regimes and the factors that condition their perception is important in designing policies for sustainable use of natural resources. This study considers how the local communities perceive the management regimes in terms of meeting the goal of utilising and conserving forest biodiversity. Satisfaction ranking showed that the strictest regime among the three was ranked highest overall. Coincidentally, the highest ranked regime has the best performance among the three in conserving the forest in its pristine state. An ordered logit regression was used to analyse factors influencing the overall satisfaction ranking. The results indicate that socio-economic factors are not significant in explaining the level of satisfaction ranking but involvement in forest conservation activities appears important in explaining satisfaction ranking. The paper concludes by highlighting some policy implications of the results.

Riha SJ;, Blume LE;, Barret CB;, Kinyangi JM;, Lehmann CJ;, Marenya PP;, Mbugua DM;, Nicholson CF;, Ngoze SO;, Parsons D;, Verchot LV;, Pell AN. "Long-Term Human and Biophysical Dynamics of Soil Degradation in the Kenyan Highlands.".; 2006. Abstract

Agroecosystems are among the most tightly coupled of human and natural systems, as farmers make conscious decisions regarding land use and improvement, cropping systems, livestock management and labor allocation. These decisions can profoundly impact the natural resource base, which can then lead to changes in farmers' behaviors. The focus of this study is to understand the long term human and biophysical dynamics of soil degradation. We are especially interested in the role that soil degradation plays in creating poverty traps and in interventions that will strongly impact the dynamics of these systems. We have developed an integrated economic and biophysical systems dynamic model to understand and predict the long term behavior of farms in the Kenyan highlands. Additionally, we have established a chronosequence in western Kenya of farms converted from primary forest to agriculture 100, 70, 50, 30, 15, 5, and < 3 years ago. This chronosequence includes three blocks that contain all time conversions, with 3 farms per conversion. Soil chemistry and soil organic matter fractions have been measured from fields that have never received fertilizer additions. An extensive set of fertility experiments to examine the response of maize to amendment with nitrogen and phosphorus fertilizers, manure and green manure have been established on these soils. Socioeconomic data for these farms has been collected. The chronosequence data is being used to both parameterize and evaluate the model. Preliminary findings indicate that both soil organic matter and maize yields decline after conversion from primary forest, but not at the same rates. As the soil degrades and maize yields decrease, farms become more diversified by shifting some land into perennials. This change in land use is associated with a stable, though decreased, soil fertility level. The relationship of these changes in cropping systems and soil fertility to off farm activities and income will be discussed, as well as the implications of these dynamics for preventing soil degradation and restoring fertility.

Olwal TO, Van Wyk MA, Van Wyk MA, Odhiambo M, Van Wyk BJ. "Low Variance Timing Recovery in Turbo Receivers."; 2006.
DR. ANYANGO BEATRICE. "L.C.Me.ndoca Haggler, I.S. de Melo, M.C.Valadares-Inglis,B..Anyango,J.O.Sequeira,Pham Van Toan and R.E.Wheatly.( 2006) Non Target and Biodiversity Impacts in Soil. In. .A.Hilbeck , D.A. Andow. And E.M.G.Fontes.(eds.". In: Published by the Democratization and Research Centre, Rome, Vol. 27, No. 3, March. El-Banhawy, E. M.; 2006. Abstract
We surveyed the phytoseid mites in four different geographical zones of Kenya: Zone I, upper highland and tropical alpine (2400-4400m): Zone II, lower highland (1800-2400m); zone III, midland (800-1800m); Zone IV, tropical, hot and humid( 0-800m ). A total of 107 species was found. In the sub family, amblyseeinae there were 14 species in the genus Neoseilus , one in Aspereroseius Chant, one in Paraphytoseius Swirski &Schechter, five in typhlodromips De Leon, five in Transeius Chant & McMurty, one in Graminaseius Chant &McMurty, 11 in Amblyseius Berlese, one in Arrenoseius Wanstein, two in Typhlodromalus muma, seven in Ueckemannseius Chant &McMurty, one in Ambylodromalus Chant &Mcmurty,, 20 in Euseius Wanstein, one in Iphiseius Berlese, one in Phytoseilus Evans and one in Gynaseius Ehara & Imano. In the subfamily Phytoseiinae Berlese there were four species in the genus Phytoseiius Ribaga. In the subfamily Typhlodrominae Wanstein, there were four species in the genus Kuzinellus Wainstein and 27 in Typhlodromus Scheuten
OKOTH PROFOGENDOHASTINGW. ""Land and Human Rights" paper submitted to the Kenya National Human Rights Commission for the 5th Edition of NGUZO ZA HAKI.". In: Cent. Afri. J. Pharm.Sci. 5(3): 60-66. Cent. Afri. J. Pharm.Sci. 5(3): 60-66; 2006. Abstract
The identification of five novel compounds, pseudo-erythromycin A-6,9-hemiketal, 8,9-anhydro-pseudo-erythromycin A-6,9-hemiketal, 8,9-anhydro-pseudo-N-demethylerythromycin A-6,9-hemiketal, 5-O-beta-D-desosaminylerythronolide A and 15-nor-erythromycin C, in mother liquor concentrates of Streptomyces erythraeus is described. The pseudo-erythromycin derivatives are characterized by a 12-membered macrocyclic ring as a result of C13––C11 trans-lactonization. The five compounds have very little antimicrobial activity.
M PROFSYAGGAPAUL. "Land Ownership and Uses in Kenya:Policy Prescriptions from an Inequality Perspective.". In: Regional workshop on Role of Geoinformation in National Development, 25th to 26th August,2008.Regional centre for Mapping of Resources for Development,Nairobi. Society for International Development; 2006. Abstract
The objective of this study is to inveigate the real inequality perspective of land ownership and use in Kenya. The study demonstrated that there are varying degrees of inequality in land ownership, access and use in Kenya in terms of land tenure, land size and land potential.The study recommends a review of the constitution,legal and administrative frameworks so as to provide for equitable,transparent and accountable land management and administration.
OKOTH PROFOGENDOHASTINGW. ""Land policies in Sub-Saharan Africa: An Overview" in Akinyi Nzioki, Land Policies in Sub-Sahara Africa, Centre for Land,Economy and rights of women,.". In: Cent. Afri. J. Pharm.Sci. 5(3): 60-66. Cent. Afri. J. Pharm.Sci. 5(3): 60-66; 2006. Abstract
The identification of five novel compounds, pseudo-erythromycin A-6,9-hemiketal, 8,9-anhydro-pseudo-erythromycin A-6,9-hemiketal, 8,9-anhydro-pseudo-N-demethylerythromycin A-6,9-hemiketal, 5-O-beta-D-desosaminylerythronolide A and 15-nor-erythromycin C, in mother liquor concentrates of Streptomyces erythraeus is described. The pseudo-erythromycin derivatives are characterized by a 12-membered macrocyclic ring as a result of C13––C11 trans-lactonization. The five compounds have very little antimicrobial activity.
OKOTH PROFOGENDOHASTINGW. ""Land Rights in Africa: Interrogating the tenure security discourse" paper for the IFAD MLWE UNOPS workshop on land tenure security.Kampla Uganda, June 26-30.". In: Cent. Afri. J. Pharm.Sci. 5(3): 60-66. Cent. Afri. J. Pharm.Sci. 5(3): 60-66; 2006. Abstract
The identification of five novel compounds, pseudo-erythromycin A-6,9-hemiketal, 8,9-anhydro-pseudo-erythromycin A-6,9-hemiketal, 8,9-anhydro-pseudo-N-demethylerythromycin A-6,9-hemiketal, 5-O-beta-D-desosaminylerythronolide A and 15-nor-erythromycin C, in mother liquor concentrates of Streptomyces erythraeus is described. The pseudo-erythromycin derivatives are characterized by a 12-membered macrocyclic ring as a result of C13––C11 trans-lactonization. The five compounds have very little antimicrobial activity.
O. PROFNDINYA-ACHOLAJ. "Lavreys L, Baeten JM, Panteleeff DD, Richardson BA, McClelland RS, Chohan V, Mandaliya K, Ndinya-Achola JO, Overbaugh J.High levels of cervical HIV-1 RNA during early HIV-1 infection.AIDS. 2006 Nov 28;20(18):2389-90.". In: AIDS. 2006 Nov 28;20(18):2389-90. IBIMA Publishing; 2006. Abstract
Few data are available on genital tract viral replication early after HIV-1 acquisition, when infectivity is high. We compared cervical HIV-1 RNA from 60 women with paired samples from within 90 days after HIV-1 acquisition and at viral setpoint (4-24 months). Cervical HIV-1 was higher in early compared with setpoint samples (mean 3.43 versus 2.85 log10 copies/swab, P < 0.001). After adjusting for HIV-1-plasma RNA, cervical HIV-1 RNA from 30 days or less after infection was increased by 0.45 log10 copies/swab (P = 0.006).
M. DRWASIKEADUA. "Lecture Notes in Ordinary differential Equations II:.". In: University of Nairobi (2006). Starmat Designers & Allied, Nairobi; 2006. Abstract
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M. DRWASIKEADUA. "Lecture Notes in Ordinary differential Equations III:.". In: University of Nairobi (2006). Starmat Designers & Allied, Nairobi; 2006. Abstract
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L DRLEGGEPATRICK. "Legge, P.L.: Guides and Techniques for Mineral Exploration,.". In: Research and Extension Results, Margarini Settlement Scheme Agronomy Programme - Short Rains 1978. Margarine Project Report. Heinrich Boll Foundation.; 2006.
DAVID PROFJOSHIMARK. "Letter to Editor;To observe the association between the staple Ethiopian diets and cancer of the oesophagus. Joshi MD.". In: East Afr Med J. 2006 May;83(5):292. East African Medical Journal.; 2006. Abstract
OBJECTIVES: To estimate the magnitude of laboratory defined Tumour Lysis Syndrome (TLS) at Kenyatta National Hospital (KNH), identify its pattern of presentation, resolution, and determine the biochemical outcome of affected patients. DESIGN: Prospective patient-treatment cohort study. SETTING: Kenyatta National Referral and Teaching Hospital, between November 2004 and April 2005. SUBJECTS: One hundred and forty two patients receiving first course chemotherapy. MAIN OUTCOME MEASURE: Laboratory defined Tumour Lysis Syndrome (TLS). RESULTS: One hundred and eleven patients completed the study protocol. Forty two patients (37.8%) developed TLS. The incidence in haematological malignancies was 75.5% while in non-haematological malignancies was 3.6%. Hyperphosphataemia and hyperkalaemia were the most consistent diagnostic parameters while hyperuricaemia occurred in only one patient. No patient developed hypocalcaemia. Ninety five percent of patients developed TLS within the first three days of receiving chemotherapy while 55% resolved in the first week. Two TLS case mortalities occurred. CONCLUSIONS: The incidence of TLS in this cohort study was 38%, and was highest among haematological malignancies. No cases occurred in breast cancer patients. Majority of the cases were diagnosed on the basis of increase in serum phosphate and potassium; uric acid did not rise predominantly due to prophylactic uricosuric therapy. A majority (95%) developed within three days of commencing chemotherapy.
O DRMUSANDUJOYCE. "Linnea U Warenius E, Faxelid Petronella Shichimba, Joyce O Musandu et al Nurse-Midwives.". In: Reproductive Health Matters Volume 14 No 27 May 2006. James Murimi; 2006. Abstract

Warenius LU, Faxelid EA, Chishimba PN, Musandu JO, Ong'any AA, Nissen EB.

Division of International Health, Department of Public Health Sciences, Karolinska Institute, Stockholm, Sweden. Linnea.Warenius@ki.se

Adolescent sexuality is a highly charged moral issue in Kenya and Zambia. Nurse-midwives are the core health care providers of adolescent sexual and reproductive health services but public health facilities are under-utilised by adolescents. The aim of this study was to investigate attitudes among Kenyan and Zambian nurse-midwives (n=820) toward adolescent sexual and reproductive health problems, in order to improve services for adolescents. Data were collected through a questionnaire. Findings revealed that nurse-midwives disapproved of adolescent sexual activity, including masturbation, contraceptive use and abortion, but also had a pragmatic attitude to handling these issues. Those with more education and those who had received continuing education on adolescent sexuality and reproduction showed a tendency towards more youth-friendly attitudes. We suggest that critical thinking around the cultural and moral dimensions of adolescent sexuality should be emphasised in undergraduate training and continuing education, to help nurse-midwives to deal more empathetically with the reality of adolescent sexuality. Those in nursing and other leadership positions could also play an important role in encouraging wider social discussion of these matters. This would create an environment that is more tolerant of adolescent sexuality and that recognises the beneficial public health effect for adolescents of greater access to youth-friendly sexual and reproductive health services.

PMID: 16713886 [PubMed - indexed for MEDLINE]

PATRICIA PROFKAMERMBOTEI. "'Land Tenure, Land Use and Sustainability in Kenya: Towards Innovative Use of Property Rights in Wildlife Management' in C.O. Okidi et al. eds., Land Use for Sustainable Development, Cambridge University Press, New York.". In: journal. Israel Journal of Veterinary Medicine; 2005. Abstractland_tenure.pdf

Antibody responses to a conventional rabies preexposure regimen of a new purified Vero cell rabies vaccine (PVRV) and a human diploid cell vaccine (HDCV) were compared in 80 healthy Kenyan veterinary students. Forty-three of the students received the PVRV and 37 received the HDCV on days 0, 7, and 28. Antibody responses were monitored using the rapid fluorescent-focus inhibition test (RFFIT) and an inhibition enzyme immunoassay (INH EIA) on days 0, 7, 28, and 49. Both vaccines elicited a rapid antibody response. A good correlation between the RFFIT titers and the INH EIA titers was obtained (r = 0.90). Our results also showed that the INH EIA was more reproducible and might therefore be a suitable substitute for the more expensive and less reproducible RFFIT. The geometric mean titers determined by both tests in the two groups of students were statistically similar during the test period. The RFFIT and the INH EIA gave comparable geometric mean titers, which differed significantly only on day 28 in the PVRV group. The effect of the new PVRV is comparable to that of the more expensive HDCV, as determined by the present test systems. The PVRV could therefore be the vaccine of choice, especially in tropical rabies-endemic areas, where the high cost of the HDCV has confined its use to a privileged few.

WACHEGE PATRICK. "Living to Die, Dying to Live: African Christian Insights, 2nd Edition, Nairobi.". In: Paulines Publications Africa. Nairobi: Heinrich Boll Foundation.; 2005.
TOM DONDICHO. "Land alienation, land tenure and tourism in Maasailand, Kenya.". In: International Journal of Business and Economic Review, , Vol. 10, No. 1, (2012): 97-111. Mila, 6: 64-72.; 2005.
TOM DONDICHO. "Land alienation, land tenure and tourism in Maasailand, Kenya.". In: Journal of Dental Research, 2002. Mila, 6: 64-72.; 2005. Abstract
This study examined issues of power and politics associated with Masaai community involvement in conservation-orientated tourism development in Amboseli, Kenya. Using two case studies of communities involved in community-based wildlife and cultural tourism, the study analyzed how and on what terms the Maasai were involved in tourism development, the nature of their engagement with external tourism stakeholders, the initiatives they have undertaken to gain closer control over the organization and economics of tourism, and the opportunities and constraints associated with this development process. The study found that competition and political rifts between clans, age-sets and political allegiances in the communities involved had prevented them from capitalizing on the tourism potential in the area which was instead exploited by foreign tourism investors and tour operators, the government and a few local elites. The research provides valuable insights into the vulnerability of indigenous communities in the face of global tourism.
M. MRMAINADAVID. "Lead Concentration in Milk and Cereal Products commonly consumed in Kenya.". In: Inaugural National Nutrition Congress . Philosophical Issues Invoked by Shona People; 2005. Abstract
Environmental pollutants arise from many sources, and exposure may occur through different routes. Some pollutants of particular concern are airborne substances, which occur primarily in suspended particles. These include sulphur dioxide, nitrogen oxides, ozone, carbon monoxide and lead oxide, among others. Although lead is an environmental and public health hazard of global proportions, the global dimensions of poisoning emanating from this heavy metal remain poorly understood due to persistent lack of information. Leaded petrol (gasoline) causes more widespread human exposure to lead than any other single source. Objective: The main objective of this study was to determine the extent of lead contamination in milk and some selected commercial flour brands in Kenya.
M. DRWASIKEADUA. "Lecture Notes in Ordinary differential Equations I:.". In: University of Nairobi (2005). Starmat Designers & Allied, Nairobi; 2005. Abstract
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M. DRWASIKEADUA. "Lecture Notes in Ordinary differential Equations I:.". In: University of Nairobi (2005). Starmat Designers & Allied, Nairobi; 2005. Abstract
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M. DRWASIKEADUA. "Lecture Notes in Ordinary differential Equations I:.". In: University of Nairobi (Electronic content- Asynchronize mode(2005. Starmat Designers & Allied, Nairobi; 2005. Abstract
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L DRLEGGEPATRICK. "Legge, P.L.: Natural Resources and Environment.". In: Nairobi, Kenya. Heinrich Boll Foundation.; 2005.
PROF. MWANGI RICHARDW. "Life against HIV/AIDS-epidemiology,blood safety and research.". In: IDA - 3340-01/02-Rep-02/(4) KNA. Pp.20. The Icfai University Journal of Architecture, Vol. II No.1, February 2010; 2005.
GODFREY PROFMURIUKI. ""Life and Government of Jomo Kenyatta".". In: In Encyclopedia of African History, Fitzroy Dearborn, New York, Volume 2,pp 755-57.; 2005. Abstract
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FREDRICK DROTIENOCF, N PROFOGOLAELIJAHS. "Lipid profile of ambulatory patients with type 2 diabetes mellitus at Kenyatta National Hospital, Nairobi. East Afr Med J. 2005 Dec;82(12 Suppl):S173-9.". In: East Afr Med J. 2005 Dec;82(12 Suppl):S173-9. F.N. kamau, G. N Thothi and I.O Kibwage; 2005. Abstract
BACKGROUND: Patients with type 2 diabetes are at high of cardiovascular events because they have abnormal lipid status compared to their non-diabetic counterparts. OBJECTIVE: To determine the quantitative lipid profile of ambulatory patients with type 2 diabetes mellitus. DESIGN: Prospective, cross-sectional descriptive study. SETTING: Out-patient diabetic clinic of the Kenyatta National Hospital. SUBJECTS: Ambulatory patients with type 2 diabetes but without obvious cardiovascular, renal or foot complications. RESULTS: A total of 213 patients with type 2 diabetes were studied, 56.8% were females. The age range of the study population was 34 to 86 years, mean(sd) age of females was 54.45 (9.4) years and that of males was 55.83 (9.3) years. The mean body mass index (BMI) of females was 27.85 (6.2) kg/m2 and 25.98 (5.8) kg/m2 for males. The female subjects were more obese than the males in this study. Over 70% of the study participants had total cholesterol > 4.2 mmol/l, 43.8% and 57.6% of the females and males respectively had LDL-C > 2.6 mmol/l , 25.6% of the females and 30% of the males had HDL-C < 1.00 mmol/l. Only a modest proportion of males (28.3%) and females (32.2%) had triglycerides > 1.7 mmol/l. The LDL-C showed a significant positive correlation with age, duration of diabetes, fasting blood glucose, and total cholesterol but no correlation with glycated haemoglobin, body mass index, gender and the mode of glucose-lowering treatment. CONCLUSION: There was significant proportion of quantitative dyslipidaemia in the study population especially with the Total–and LDL- cholesterols. Although treatment goals and lipid thresholds for cardiovascular risk in diabetes are not yet well-defined, even by the large randomized trials, high-risk patients with significant quantitative dyslipidaemia would require deliberate effort to correct the abnormal values to reduce the risk status. These high-risk patients without complications but already had significant dyslipidaemia, which enhances the risk of cardiovascular events, certainly required therapeutic intervention.
FREDRICK DROTIENOCF, N PROFOGOLAELIJAHS. "Lipid profile of ambulatory patients with type 2 diabetes mellitus at Kenyatta National Hospital, Nairobi. East Afr Med J. 2005 Dec;82(12 Suppl):S173-9.". In: East Afr Med J. 2005 Dec;82(12 Suppl):S173-9. Kisipan, M.L.; 2005. Abstract
BACKGROUND: Patients with type 2 diabetes are at high of cardiovascular events because they have abnormal lipid status compared to their non-diabetic counterparts. OBJECTIVE: To determine the quantitative lipid profile of ambulatory patients with type 2 diabetes mellitus. DESIGN: Prospective, cross-sectional descriptive study. SETTING: Out-patient diabetic clinic of the Kenyatta National Hospital. SUBJECTS: Ambulatory patients with type 2 diabetes but without obvious cardiovascular, renal or foot complications. RESULTS: A total of 213 patients with type 2 diabetes were studied, 56.8% were females. The age range of the study population was 34 to 86 years, mean(sd) age of females was 54.45 (9.4) years and that of males was 55.83 (9.3) years. The mean body mass index (BMI) of females was 27.85 (6.2) kg/m2 and 25.98 (5.8) kg/m2 for males. The female subjects were more obese than the males in this study. Over 70% of the study participants had total cholesterol > 4.2 mmol/l, 43.8% and 57.6% of the females and males respectively had LDL-C > 2.6 mmol/l , 25.6% of the females and 30% of the males had HDL-C < 1.00 mmol/l. Only a modest proportion of males (28.3%) and females (32.2%) had triglycerides > 1.7 mmol/l. The LDL-C showed a significant positive correlation with age, duration of diabetes, fasting blood glucose, and total cholesterol but no correlation with glycated haemoglobin, body mass index, gender and the mode of glucose-lowering treatment. CONCLUSION: There was significant proportion of quantitative dyslipidaemia in the study population especially with the Total–and LDL- cholesterols. Although treatment goals and lipid thresholds for cardiovascular risk in diabetes are not yet well-defined, even by the large randomized trials, high-risk patients with significant quantitative dyslipidaemia would require deliberate effort to correct the abnormal values to reduce the risk status. These high-risk patients without complications but already had significant dyslipidaemia, which enhances the risk of cardiovascular events, certainly required therapeutic intervention.
CHEGE MRMUNGAIJOSEPH. "Literacy In Perspective .". In: Bristol University, UK, September 1989. University of Nairobi; 2005. Abstract
Seventeen cows of various breeds with varying degrees of severity of advanced ocular squamous cell carcinoma were treated by radical surgery, which included enucleation and extirpation of the surrounding ocular muscles and tissues. The degree of severity and the extent of the carcinoma lesion was correlated with the outcome of treatment for each case. It was observed that: 1. eyeball involvement, 2. ulceration and subsequent infection of carcinoma lesion involving the eyelids and 3. involvement of the regional lymphnodes especially the parotid , are some of the main factors that could be used to draw prognosis of such cases. Although the initial surgery may not be costly, the overall cost of managing postoperative complications is prohibitive and results to vast economic losses that should not be ignored.
JAMES PROFODEK. "The Lome Conventions (1975-2000): Background to the Trade Relationship Between Africa-Caribbean-Pacific Countries and the European Economic Communities.". In: Paper presented at the WIPO High Level Forum on IP Policy and Strategy, Tokyo . Prof. James Otieno-Odek; 2005. Abstract
J. O. Midiwo, A. Yenesew, B. F. Juma, S. Dereses, J. A. Ayoo, A. Aluoch and S. Guchu There are several described medicinal plants in Kenya from a flora of approximately 10,000 members. Strong cross-medical information from the 42 ethnic groups points to the high potential of some of these species. The Myrsinaceae are well established ethno-anthelmintics and anti-bacterials. They are harbingers of long alkyl side chain benzoquinones which clearly have a protective function from their histochemical disposition. The main benzoquinone in the sub-family Myrsinodae is embelin while for the Maesodae it is maesaquinone together with its 5-acetyl derivative; the distribution of these benzoquinones by their alkyl side chain length or the presence/absence of a 6-methyl group is in accord with morphological sub-family de-limitation. The benzoquinones showed anti-feedant, anti-microbial, phytotoxic, acaricidal, insecticidal and nematicidal activity. Many other benzoquinones of medium and minor concentration were also isolated and characterised. Some plants belonging to the Polygonaceae which are widely used as ethno-anthelmintics have been studied. The common anthelmintic anthraquinones were obtained from all five Rumex species while the naphthalenic acetogenin derivative, nepodin was more selectively distributed. The leaf of Polygonum senegalense is up to 17% surface exudate; about thirteen non polar flavonoid derivatives (chalcones, dihydrochalcones, flavanones and a flavone) have been isolated from it. From the internal aerial tissues of this plant, the major flavonoids were common flavonoids, quercetin, kaempferol, luteolin and their glycosides. The only unique compound isolated from this plant was 2prime-glucosyl-6prime-hydroxy-4prime-methoxydihydrochalcone whose aglycone, uvangolatin is part of the exudate mixture. Other leaf exudate plants studied include the stomach-ache medicine, Psiadia punctulata (Compositae) from which novel methylated flavonoids, kaurene and trachyloban diterpenes have been found
MBORI- PROFNGACHADOROTHYA, ELIZABETH DROBIMBO. "Longitudinal assessment of human immunodeficiency virus type 1 (HIV-1)-specific gamma interferon responses during the first year of life in HIV-1-infected infants. J Virol . 2005 Jul; 79 ( 13 ): 8121-30 . PMID: 15956557 [PubMed - indexed for MEDLINE] Lohm.". In: J Virol . 2005 Jul; 79 ( 13 ): 8121-30 . Kisipan, M.L.; 2005. Abstract
Department of Paediatrics, University of Nairobi, Kenya. bllohman@iconnect.co.ke Human immunodeficiency virus type 1 (HIV-1) infection results in different patterns of viral replication in pediatric compared to adult populations. The role of early HIV-1-specific responses in viral control has not been well defined, because most studies of HIV-1-infected infants have been retrospective or cross-sectional. We evaluated the association between HIV-1-specific gamma interferon (IFN-gamma) release from the cells of infants of 1 to 3 months of age and peak viral loads and mortality in the first year of life among 61 Kenyan HIV-1-infected infants. At 1 month, responses were detected in 7/12 (58%) and 6/21 (29%) of infants infected in utero and peripartum, respectively (P = 0.09), and in approximately 50% of infants thereafter. Peaks of HIV-specific spot-forming units (SFU) increased significantly with age in all infants, from 251/10(6) peripheral blood mononuclear cells (PBMC) at 1 month of age to 501/10(6) PBMC at 12 months of age (P = 0.03), although when limited to infants who survived to 1 year, the increase in peak HIV-specific SFU was no longer significant (P = 0.18). Over the first year of life, infants with IFN-gamma responses at 1 month had peak plasma viral loads, rates of decline of viral load, and mortality risk similar to those of infants who lacked responses at 1 month. The strength and breadth of IFN-gamma responses at 1 month were not significantly associated with viral containment or mortality. These results suggest that, in contrast to HIV-1-infected adults, in whom strong cytotoxic T lymphocyte responses in primary infection are associated with reductions in viremia, HIV-1-infected neonates generate HIV-1-specific CD8+-T-cell responses early in life that are not clearly associated with improved clinical outcomes. PMID: 15956557 [PubMed - indexed for MEDLINE] PMCID: PMC1143755
MBORI- PROFNGACHADOROTHYA, ELIZABETH DROBIMBO. "Longitudinal assessment of human immunodeficiency virus type 1 (HIV-1)-specific gamma interferon responses during the first year of life in HIV-1-infected infants. J Virol . 2005 Jul; 79 ( 13 ): 8121-30 . PMID: 15956557 [PubMed - indexed for MEDLINE] Lohm.". In: J Virol . 2005 Jul; 79 ( 13 ): 8121-30 . Earthscan, London. 978-1-84407-469-3 (*); 2005. Abstract
Department of Paediatrics, University of Nairobi, Kenya. bllohman@iconnect.co.ke Human immunodeficiency virus type 1 (HIV-1) infection results in different patterns of viral replication in pediatric compared to adult populations. The role of early HIV-1-specific responses in viral control has not been well defined, because most studies of HIV-1-infected infants have been retrospective or cross-sectional. We evaluated the association between HIV-1-specific gamma interferon (IFN-gamma) release from the cells of infants of 1 to 3 months of age and peak viral loads and mortality in the first year of life among 61 Kenyan HIV-1-infected infants. At 1 month, responses were detected in 7/12 (58%) and 6/21 (29%) of infants infected in utero and peripartum, respectively (P = 0.09), and in approximately 50% of infants thereafter. Peaks of HIV-specific spot-forming units (SFU) increased significantly with age in all infants, from 251/10(6) peripheral blood mononuclear cells (PBMC) at 1 month of age to 501/10(6) PBMC at 12 months of age (P = 0.03), although when limited to infants who survived to 1 year, the increase in peak HIV-specific SFU was no longer significant (P = 0.18). Over the first year of life, infants with IFN-gamma responses at 1 month had peak plasma viral loads, rates of decline of viral load, and mortality risk similar to those of infants who lacked responses at 1 month. The strength and breadth of IFN-gamma responses at 1 month were not significantly associated with viral containment or mortality. These results suggest that, in contrast to HIV-1-infected adults, in whom strong cytotoxic T lymphocyte responses in primary infection are associated with reductions in viremia, HIV-1-infected neonates generate HIV-1-specific CD8+-T-cell responses early in life that are not clearly associated with improved clinical outcomes. PMID: 15956557 [PubMed - indexed for MEDLINE] PMCID: PMC1143755
PROF. MAVUTI KENNETHM. "Louisiana crayfish (Procambarus clarkii) (Crustacea: Cambaridae) in Kenyan ponds: non-target effects of a potential biological control agent for schistosomiasis.". In: African Journal of Aquatic Science 2005, 30(2). Vaccine 26:2788- 2795; 2005. Abstract
Normal 0 false false false MicrosoftInternetExplorer4 st1:*{behavior:url(#ieooui) } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} Macrophytes have been shown to perform important ecological roles in Lake Naivasha. Consequently, various studies regarding the impact of biotic factors on the macrophytes have been advanced but related studies on environmental parameters have lagged behind. In an attempt to address this gap, sampling on floating species and submergents was carried out in eight sampling sites in 2003 to investigate how they were influenced by a set of environmental factors. Soil texture (sandy sediments; P < 0.05, regression coefficient = - 0.749) and wind were the most important environmental parameters influencing the distribution and abundance of floating macrophytes. Combination of soil texture and lake-bed slope explained the most (86.3%) variation encountered in the submergents. Continuous translocation of the floating dominant water hyacinth to the western parts by wind has led to displacement of the submergents from those areas. In view of these findings, the maintenance and preservation of the steep Crescent Lake basin whose substratum is dominated by sand thus hosting most submergents remain important, if the whole functional purpose of the macrophytes is to be sustained.
N PROFLULEGODFREY. "Lule GN. Helicobacter pylori eradication in peptic dyspepsia. East Afr Med J. 2005 Dec;82(12):601-2. No abstract available.". In: East Afr Med J. 2005 Dec;82(12):601-2. test; 2005. Abstract

OBJECTIVE: To evaluate the utility of Total Lymphocyte Count (TLC) as a surrogate marker for CD4 + T cell count in antiretroviral (ARV) treatment initiation in a Kenyan population of HIV seropositive patients at Kenyatta National Hospital. DESIGN: Cross-sectional descriptive study. SETTING: Kenyatta National Hospital, HIV treatment and follow-up outpatient facility; Comprehensive Care Centre, Nairobi, Kenya. SUBJECTS: Two hundred and twenty five HIV Elisa positive, ARV naive patients visiting the Comprehensive Care Centre between January 2006 to March 2006. RESULTS: A significant linear correlation was found between TLC and CD4 cell count for the whole group with a Spearman rank correlation of 0.761 (p < 0.01); and was also independently observed in the four WHO clinical stages. The classification utility of TLC 1200 cells/mm3 cut-off was suboptimal; sensitivity 37% specificity of 99% and the NPV of 56%. The receiver operator characteristics (ROC) curve generated an optimal TLC cut-off of 1900 cells/mm3 cut-off to be of greatest utility with a sensitivity of 81.1%, specificity of 90.3%, PPV of 90.8% and NPV of 80.2%. This implies that a TLC cut-off of 1900 cells/mm3 correctly classify eight out of ten HIV positive patients as having a CD4 < 200 cells/mm3 and only misclassify two such patients. Serial CD4 testing can then be performed on the minority of patients who despite a TLC > or = 1900 cells/mm3 are, on basis of clinical data, suspect of more advanced disease warranting ARV therapy. This would reduce the number of patients tested for and focus the application of CD4 testing and thus reduce attendant cost in care provision in CD4 resource poor settings. CONCLUSION: Our data showed a good positive correlation between TLC and CD4 cell count, however the WHO recommended TLC cuto-ff of 1200/mm3 was found to be of low sensitivity in classifying patients as having a CD4 counts < 200 cells/mm3. This would result in underestimation of advanced stage of disease and to withholding ARVs treatment to persons who need treatment. We recommend a TLC cut-off of 1900 cells/mm3 for our population to classify patients as either above or below the CD4 count cut-off of 200 cells/mm3 as an indicator of when to start antiretroviral therapy.

B. PROFESTAMBALEBENSON. "Luoba AI, Wenzel Geissler P, Estambale B, Ouma JH, Alusala D, Ayah R, Mwaniki D, Magnussen P, Friis H. Earth-eating and reinfection with intestinal helminths among pregnant and lactating women in western Kenya. Trop Med Int Health. 2005 Mar;10(3):220-7.". In: Trop Med Int Health. 2005 Mar;10(3):220-7. Taylor & Francis; 2005. Abstract
We conducted a longitudinal study among 827 pregnant women in Nyanza Province, western Kenya, to determine the effect of earth-eating on geohelminth reinfection after treatment. The women were recruited at a gestational age of 14-24 weeks (median: 17) and followed up to 6 months postpartum. The median age was 23 (range: 14-47) years, the median parity 2 (range: 0-11). After deworming with mebendazole (500 mg, single dose) of those found infected at 32 weeks gestation, 700 women were uninfected with Ascaris lumbricoides, 670 with Trichuris trichiura and 479 with hookworm. At delivery, 11.2%, 4.6% and 3.8% of these women were reinfected with hookworm, T. trichiura and A. lumbricoides respectively. The reinfection rate for hookworm was 14.8%, for T. trichiura 6.65, and for A. lumbricoides 5.2% at 3 months postpartum, and 16.0, 5.9 and 9.4% at 6 months postpartum. There was a significant difference in hookworm intensity at delivery between geophagous and non-geophagous women (P=0.03). Women who ate termite mound earth were more often and more intensely infected with hookworm at delivery than those eating other types of earth (P=0.07 and P=0.02 respectively). There were significant differences in the prevalence of A. lumbricoides between geophagous and non-geophagous women at 3 (P=0.001) and at 6 months postpartum (P=0.001). Women who ate termite mound earth had a higher prevalence of A. lumbricoides, compared with those eating other kinds of earth, at delivery (P=0.02), 3 months postpartum (P=0.001) and at 6 months postpartum (P=0.001). The intensity of infections with T. trichiura at 6 months postpartum was significantly different between geophagous and non-geophagous women (P=0.005). Our study shows that geophagy is associated with A. lumbricoides reinfection among pregnant and lactating women and that intensities built up more rapidly among geophagous women. Geophagy might be associated with reinfection with hookworm and T. trichiura, although these results were less unequivocal. These findings call for increased emphasis, in antenatal care, on the potential risks of earth-eating, and for deworming of women after delivery.
OLONDE PROFAMAYOERASTUS, OTIENO PROFOGUTUELLY. "Lwai-Lume L, Ogutu EO, Amayo EO, Kariuki S.Drug susceptibility pattern of Helicobacter pylori in patients with dyspepsia at the Kenyatta National Hospital, Nairobi.East Afr Med J. 2005 Dec;82(12):603-8.". In: East Afr Med J. 2005 Dec;82(12):603-8. Journal of British Ceramic Transactions, 99 [5], 206-211.; 2005. Abstract
OBJECTIVE: To determine drug susceptibility pattern of Helicobacter pylori to metronidazole, clarithromycin, amoxicillin and tetracycline in patients presenting with dyspepsia at the Kenyatta National Hospital. DESIGN: Cross-sectional descriptive study. SETTING: Kenyatta National Hospital, Nairobi. SUBJECTS: Two hundred and sixty-seven patients aged 15 to 85 years, presenting with dyspepsia and referred for upper gastro-intestinal endoscopy were recruited into the study. RESULTS: Between October 2003 and April 2004, 138 male and 129 female patients aged 15-85 years, with a mean age of 45.4 years were studied. Gastritis was the most common endoscopic finding, occurring in 55%, followed by normal-looking mucosa in 27% and peptic ulcer disease in 16% of the patients. The rapid urease test was positive in 184 patients (69%). The culture yield was 62% of these CLO (Campylobacter like organisms) positive biopsies. The MIC90 (minimum inhibitory concentration) was 256 mg/l for metronidazole, 1.5 mg/l for clarithromycin, 1.5 mg/l for tetracycline and 0.75 mg/l for amoxicillin. The MIC values for amoxicillin were significantly higher in the female patients (p = 0.02) but showed no significant variation for age. The MIC values for metronidazole, tetracycline and clarithromycin showed no significant difference for age or gender. MIC values for tetracycline were significantly higher for patients with duodenitis and duodenal ulcer p = 0.009 and 0.02, respectively. CONCLUSION: All isolated H. pylori organisms were resistant to metronidazole. The susceptibility of the H. pylori isolates was 93.6% for clarithromycin, 95.4% for amoxicillin and 98.1% for tetracycline. The MIC90 for amoxicillin and clarithromycin were found to be close to the upper limit of the susceptibility range. There was a rising MIC90 for tetracycline and metronidazole compared to that found in a previous study in 1991.
joshua Kivuva. "Legitimizing Ethnic Citizenship as a meams of Means of Managing Ethnic Conflict in Multiethnic Africa: The Case of Kenya.". In: The Young African Scholars' Symposium on Bringing Africa to the Forefront: Contemporary International Law and Development in Africa's Century. Stanford Law School, California.; 2004.
O. PROFNDINYA-ACHOLAJ. "Lavreys L, Baeten JM, Kreiss JK, Richardson BA, Chohan BH, Hassan W, Panteleeff DD, Mandaliya K, Ndinya-Achola JO, Overbaugh J.Injectable contraceptive use and genital ulcer disease during the early phase of HIV-1 infection increase plasma virus load in w.". In: J Infect Dis. 2004 Jan 15;189(2):303-11. Epub 2004 Jan 9. IBIMA Publishing; 2004. Abstractinjectable_contraceptive_use_and_genital_ulcer_disease.docinjectable_contraceptive_use_and_genital_ulcer_disease.pdf

We examined the association between host factors present near the time of human immunodeficiency virus type 1 (HIV-1) acquisition and subsequent virus loads, in a prospective cohort study of women in Mombasa, Kenya. Women were prospectively followed monthly before HIV-1 infection. One hundred sixty-one commercial sex workers who became infected with HIV-1 were followed for a median of 34 months, and 991 plasma samples collected > or =4 months after infection were tested for HIV-1 RNA. The median virus set point at 4 months after infection was 4.46 log10 copies/mL, and the average virus load increase during subsequent follow-up was 0.0094 log10 copies/mL/month. In a multivariate analysis that controlled for sexual behavior, the use of the injectable contraceptive depot medroxyprogesterone acetate (DMPA) at the time of HIV-1 infection was associated with a higher virus set point, and the presence of genital ulcer disease (GUD) during the early phase of HIV-1 infection was associated with greater change in virus load during follow-up. These findings suggest that, in women, the use of DMPA and the presence of GUD during the early phase of HIV-1 infection may influence the natural course of infection.

Olukoye GA;, Wakhungu JW;, Wamicha, W.N.;, Kinyamario JJ;, Mwanje JL. "Livestock Versus Wildlife Ranching In Kenyan Rangelands: A Case Study Of Laikipia District Ranches.".; 2004.
Mutie S;, Mburu J;, Ackello-Ogutu C;, Guthiga P. "Local Communities' Dependence on Ntfps in Kakamega Forest: Analysis of Economic Value, and Determinants of Participation and Extraction Levels.".; 2004. Abstract

The study assesses the types and quantities of direct non-timber forest products (NTFPs) extracted by the local people living around the Kakamega Forest in Western Kenya. It further analyses the factors that influence a household's decision to participate in NTFPs' collection and the level of extraction undertaken. The results of this study are derived from a stratified sample of 370 households who were interviewed with a semi-structured questionnaire. The quantities of the different products obtained by extracting households are valued at the average market prices to obtain their financial values. The results of the study indicate that the forest generates a substantial economic value to the local people. It was found that this value is comparable to that of the common crop enterprises in the research area. A Heckman two- stage regression model is used to analyse the socio-economic, institutional, and geo-physical factors that influence the household decision to participate in forest extraction and the quantities of the different products obtained. Proximity to the forest edge, the form of forest management approach, age and education level of the household head, household private land holding and participation in forest conservation activities are the main factors influencing the household decision to extract NTFPs from the forest. The level of extraction for the participating households is influenced by their proximity to the forest, the household size, participation in forest conservation activities and whether the household uses the extracted forest products as a source of income. The study concludes by highlighting some important policy inferences for sustainable use and conservation of Kakamega Forest.

Mutie S;, Mburu J;, Ackello-Ogutu C;, Guthiga P. "Local Communities' Dependence on Ntfps in Kakamega Forest: Analysis of Economic Value, and Determinants of Participation and Extraction Levels.".; 2004. Abstract

The study assesses the types and quantities of direct non-timber forest products (NTFPs) extracted by the local people living around the Kakamega Forest in Western Kenya. It further analyses the factors that influence a household's decision to participate in NTFPs' collection and the level of extraction undertaken. The results of this study are derived from a stratified sample of 370 households who were interviewed with a semi-structured questionnaire. The quantities of the different products obtained by extracting households are valued at the average market prices to obtain their financial values. The results of the study indicate that the forest generates a substantial economic value to the local people. It was found that this value is comparable to that of the common crop enterprises in the research area. A Heckman two- stage regression model is used to analyse the socio-economic, institutional, and geo-physical factors that influence the household decision to participate in forest extraction and the quantities of the different products obtained. Proximity to the forest edge, the form of forest management approach, age and education level of the household head, household private land holding and participation in forest conservation activities are the main factors influencing the household decision to extract NTFPs from the forest. The level of extraction for the participating households is influenced by their proximity to the forest, the household size, participation in forest conservation activities and whether the household uses the extracted forest products as a source of income. The study concludes by highlighting some important policy inferences for sustainable use and conservation of Kakamega Forest.

MBURU STEPHEN. "Longhorn Secondary Computer Studies Series (Form 1 to Form 4 books.". In: European Journal of Pharmaceutical sciences. Longhorn; 2004.
WANJIRU DRNGUGIROSE, Ngugi RW. "Luka Kandie Kiptui, Exchange rate pass-through to domestic prices in Kenya: 1972-2004, University of Nairobi, 2005." The Icfai University Journal of Architecture, Vol. II No.1, February 2010; 2004.
N PROFNYAGAP. "L.W. Njagi, P.G. Mbuthia, L.C. Bebora, P.N. Nyaga, U. Minga and J.E. Olsen. Carrier status for Listreria monocytogenes and other Listeria species in free range farm and market healthy indigenous chickens and ducks. E.A.M.J.( 2004): 81:39-43.". In: Bull. Anim. Hlth. Prod. Afr. vol.58. no.1. au-ibar; 2004. Abstract

According to the statements made by a number of scholars, in the 80's East African Anglophone novel, which once received a nickname of "social documentary", began to lose gradually its social commitment. Many of the writers known previously as the most active supporters of the social trend, moved their attempts to other literan areas - criminal novel ("Weapon of hunger" by Meja Mцangi, 1989), love story (Yussuf Dawood's "Off my chest", 1988), even children's literature (books for children in Gikuyu, written by Ngugi wa Thiong'o). However, in the late 80's and early 90's East African Anglophone novel stepped onto a new level of social trend, moving from "social documentary" to "social epic". The authors now are trying to sum up the historical experience of East African countries over a large time span, and to that effect appeal mostly to elaborate and spacious literary forms, such as epic novel. These authors, although chosen one and the same literary form, are showing clearly their inclinations towards different styles of writing. For example, Tanzanian author Moyez Vassanji in his novel "The gunny sack" (1989) makes a rather convincing attempt to replant on East African soil the method of "mythological writing", previously used by such author as Gabriel Garcia Marquez. The novel definitely appeals not only to local reader, but to a wider international audience; on its pages the author manages to restore not only the fate of several generations of Indian family, but even the slightest details of their mentality, using myth as one of the basic means for changing the dimensions of time and space, according to the logic of the narration. The development of Kenyan novel in the early 90's confirms also one of the main tendencies in modem literature - bridging between "elite" and popular fiction. The first attempt of an epic novel in Kenyan Anglophone literature was, oddly enough, made by the veteran of Kenyan popular fiction David Maillu in his "Broken drum" H991). The novel hardly aims the widest reading public - nevertheless, stylistically it bears distinct features of popular fiction, such as crime story, romance, etc. Popular novel in East Africa also shows certain inclination towards urgent social themes, but the authors inevitably uses the artistic means they feel most happy with - that is, the style of popular fiction. For example, the "clash of cultures" - the experience of young Africans studying abroad - is presented in the form of a picaresque ("Times beyond" by Omondi Makoloo, 1992) or love story ("The girl from Uganda" by Tengio Urrio, 1993); feministic problems are spiced with sentimentalism ("Judy the nun" by P .Waweru, 1990); the thoughts on the hardships of younger generation are guised in Bildungs roman ("The plight of succession" by a Tanzanian Prosper Rwegoshora, 1990). At the same time, some authors, who have been ploughing successfully the field of pop fiction for a few decades, show their interest in more elaborate literary forms ("Dedan Kimathi: the real story" by Samuel Kaluga, 1990). All the mentioned facts do not allow us to state that the division into popular and elite novel will disappear within the foreseeable future. However, the most interesting developments seem to take place precisely in the field of bridging between these two branches of East African fiction.

N PROFNYAGAP. "L.W. Njagi, P.G. Mbuthia, L.C. Bebora, P.N. Nyaga, U. Minga and J.E. Olsen. Sensitivity of Listeria species, recovered from indigenous chickens to antibiotics and disinfectants. E.A.M.J. (2004): 81:44-47.". In: Bull. Anim. Hlth. Prod. Afr. vol.58. no.1. au-ibar; 2004. Abstract

According to the statements made by a number of scholars, in the 80's East African Anglophone novel, which once received a nickname of "social documentary", began to lose gradually its social commitment. Many of the writers known previously as the most active supporters of the social trend, moved their attempts to other literan areas - criminal novel ("Weapon of hunger" by Meja Mцangi, 1989), love story (Yussuf Dawood's "Off my chest", 1988), even children's literature (books for children in Gikuyu, written by Ngugi wa Thiong'o). However, in the late 80's and early 90's East African Anglophone novel stepped onto a new level of social trend, moving from "social documentary" to "social epic". The authors now are trying to sum up the historical experience of East African countries over a large time span, and to that effect appeal mostly to elaborate and spacious literary forms, such as epic novel. These authors, although chosen one and the same literary form, are showing clearly their inclinations towards different styles of writing. For example, Tanzanian author Moyez Vassanji in his novel "The gunny sack" (1989) makes a rather convincing attempt to replant on East African soil the method of "mythological writing", previously used by such author as Gabriel Garcia Marquez. The novel definitely appeals not only to local reader, but to a wider international audience; on its pages the author manages to restore not only the fate of several generations of Indian family, but even the slightest details of their mentality, using myth as one of the basic means for changing the dimensions of time and space, according to the logic of the narration. The development of Kenyan novel in the early 90's confirms also one of the main tendencies in modem literature - bridging between "elite" and popular fiction. The first attempt of an epic novel in Kenyan Anglophone literature was, oddly enough, made by the veteran of Kenyan popular fiction David Maillu in his "Broken drum" H991). The novel hardly aims the widest reading public - nevertheless, stylistically it bears distinct features of popular fiction, such as crime story, romance, etc. Popular novel in East Africa also shows certain inclination towards urgent social themes, but the authors inevitably uses the artistic means they feel most happy with - that is, the style of popular fiction. For example, the "clash of cultures" - the experience of young Africans studying abroad - is presented in the form of a picaresque ("Times beyond" by Omondi Makoloo, 1992) or love story ("The girl from Uganda" by Tengio Urrio, 1993); feministic problems are spiced with sentimentalism ("Judy the nun" by P .Waweru, 1990); the thoughts on the hardships of younger generation are guised in Bildungs roman ("The plight of succession" by a Tanzanian Prosper Rwegoshora, 1990). At the same time, some authors, who have been ploughing successfully the field of pop fiction for a few decades, show their interest in more elaborate literary forms ("Dedan Kimathi: the real story" by Samuel Kaluga, 1990). All the mentioned facts do not allow us to state that the division into popular and elite novel will disappear within the foreseeable future. However, the most interesting developments seem to take place precisely in the field of bridging between these two branches of East African fiction.

M MRMUTSOTSOBEN. "The Labour Dispute Settlement Machinery in Kenya,(2004) ILO Publication, Dar-es-Salaam.". In: African Crop Science Conference. University of Nairobi Case, in the proceedings of the IST-Africa 2008 Conference; Windhoek, Namibia; 2004. Abstract
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N. DREKAYAWELLINGTON. "Land use, ecology, and socio-economic changes in a pastoral production system. Journal of Human Ecology, 16: 83-89.". In: Journal of Human Ecology, 17: 143 . ARCHWAY Technology Management Ltd; 2004. Abstract

A study was conducted to determine dietary characteristics of sheep and Grant's gazelles on Kapiti Ranch, Kenya. The dietary botanical composition was determined using the microhistological technique. Plant species in the diets were categorized into grass, forb and browse classes. Shannon-Wiener and Morisita's similarity indices were used to express dietary diversity and overlap respectively. Diets were simulated based on microhistology results to give 50 gm samples, then analysed for crude protein, neutral detergent fibre, acid detergent fibre, cellulose, lignin, and in vitro dry matter digestibility. Sheep were predominantly grazers during dry and wet season while Grant's gazelles were mixed feeders, with a higher preference for grasses during the wet season and an equal preference for both grasses and browse during the dry season. Diets of Grant's gazelles were more diverse than those of sheep for both seasons. Degree of dietary overlap between the animal species was highest during the wet season. There were significant differences (P<0.05) in dietary nutrient content between the animal species, within seasons. Dry matter digestibility was significantly higher (P<0.05) for both species during the wet season. Neutral detergent fibre, acid detergent fibre, lignin and cellulose were significantly higher (P<0.05) during the dry season. Sheep diets were significantly higher (P<0.05) in crude protein during the wet season, whereas it was significantly higher (P<0.05) in the diets of Grant's gazelles during the dry season. Study findings indicate that, sheep and Grant's gazelles are compatible for efficient use of vegetation on Athi Kapiti plains. Integration of the two ruminants can make unique and important contribution to food production and income generation opportunities in areas with vegetation composition similar to that of Athi Kapiti plains.

O. PROFNDINYA-ACHOLAJ. "Lavreys L, Baeten JM, Martin HL Jr, Overbaugh J, Mandaliya K, Ndinya-Achola J, Kreiss JK.Hormonal contraception and risk of HIV-1 acquisition: results of a 10-year prospective study.AIDS. 2004 Mar 5;18(4):695-7.". In: AIDS. 2004 Mar 5;18(4):695-7. IBIMA Publishing; 2004. Abstract
Polymerase chain reaction was used to determine the prevalence and correlates of human herpesvirus 8 (HHV8) in saliva, mouth, cervical, vaginal, plasma, and peripheral-blood mononuclear cell (PBMC) samples from 174 HHV8-seropositive female prostitutes in Mombasa, Kenya. The prevalence of detection of HHV8 was 32% in saliva samples, 28% in mouth swabs, 4% in cervical swabs, 2.3% in vaginal swabs, 9% in plasma samples, and 18% in PBMC samples. Human immunodeficiency virus type 1 (HIV-1) seropositivity was associated with detection of HHV8 from any mucosal surface (odds ratio, 2.1 [95% confidence interval, 1.1-4.0]). In HIV-1-seropositive women, there was no association between detection of HHV8 and either CD4 count or HIV-1 viral load.
O. PROFNDINYA-ACHOLAJ. "Lavreys L, Chohan V, Overbaugh J, Hassan W, McClelland RS, Kreiss J, Mandaliya K, Ndinya-Achola J, Baeten JM.Hormonal contraception and risk of cervical infections among HIV-1-seropositive Kenyan women.AIDS. 2004 Nov 5;18(16):2179-84.". In: AIDS. 2004 Nov 5;18(16):2179-84. IBIMA Publishing; 2004. Abstract
{ OBJECTIVE: To evaluate the relationship between hormonal contraceptive use and the acquisition of cervical sexually transmitted infections (STI) among HIV-1-infected women. DESIGN: A prospective cohort study of 242 commercial sex workers in Mombasa, Kenya, followed from the time of HIV-1 infection. METHODS: At monthly follow-up visits, sexual behavior and contraceptive use were recorded, and laboratory screening for STI was performed. Multivariate Andersen-Gill proportional hazards models were constructed to examine the association between the use of hormonal contraception and the occurrence of cervical STI. RESULTS: The median duration of follow-up after HIV-1 acquisition was 35 months, and 799 person-years of follow-up were accrued. After adjustment for demographic factors and sexual behavior, women using the injectable contraceptive depot medroxyprogesterone acetate were at increased risk of Chlamydia trachomatis infection [hazard ratio (HR) 3.1, 95% confidence interval (CI) 1.0-9.4
NJAMBI MSKINYUNGUALICE, WARUE MRSKARIUKICATHERINE. "A Legal Analysis of the Real Estate Agent in the Changing Political Arena in Kenya .". In: African Journal of Ecology 46(1):22-29. uon press; 2004. Abstract
Over the last six years there has been a tremendous development of infrastructure projects in virtually all corners of Kenya. This has taken the form of Road Improvement Project, Water and sewerage improvement project and the Electricity Transmission Improvement Project as envisioned in the Kenya Vision 2030. The purpose of this paper is to investigate the principles of compulsory land acquisition and way leaves in the three sectors in Kenya by looking at the current legislative framework governing the entire process of acquisition. In considering the process, the paper explores the various provisions of the relevant act which governs the particular utility envisaged for improvement project component in the Kenya Vision 2030. A critical evaluation of the procedures adopted is outlined in each case and the general public apprehensions towards such acquisitions. The second part of the paper focuses on suggestions on the choice of valuation methodology in making claims for compensation for land for various infrastructure projects in Kenya. This is borne out of the fact that there appear to be very little standardization in the methods adopted by the various bodies. The paper cites several cases under the Electricity Transmission Improvement Project where a large proportion of way leaves are dealt with at local level, with little consistency. Coupled to this is the public concern that electricity lines have potentially serious health effects that continue to attract research and media interest. The paper concludes with a description of the various cases on how to improve compensation paid to those affected by compulsory acquisition in cases of land and way leaves.
MBAABU DRMATHIUPETER. "Leina Mpoke and Mbaabu Mathiu (2004). Traditional animal health care as part of Indigenous Knowledge (IK)practices in Kenya.". In: UoN Faculty of Veterinary Medicine Biennual Conference, Kabete. Elsevier; 2004. Abstract
Ethnopharmacological relevance: Traditional medicines play an important role in the management of chronically painful and debilitating joint conditions, particularly in the rural Africa. However, their potential use as sources of medicines has not been fully exploited. The present study was carried to find the medicinal plants traditionally used to manage chronic joint pains in Machakos and Makueni counties in Kenya. Materials and methods: To obtain this ethnobotanical information, 30 consenting traditional herbal med-ical practitioners were interviewed exclusively on medicinal plant use in the management of chronic joint pains, in a pre-planned workshop. Results and discussion: In this survey, a total of 37 plants belonging to 32 genera and 23 families were cited as being important for treatment of chronic joint pains. The most commonly cited plant species were Pavetta crassipes K. Schum, Strychnos henningsii Gilg., Carissa spinarum L., Fagaropsis hildebrandtii (Engl.) Milve-Redh. and Zanthoxylum chalybeum Engl. Acacia mellifera (Vahl) Benth., Amaranthus albus L., Balanites glabra Mildbr. & Schltr., Grewia fallax K. Schum., Lactuca capensis, Launaea cornuta (Oliv. & Hiern) O. Jeffrey, Lippia kituiensis Vatke, Pappea capensis Eckl. & Zeyh. and Pennisetum glaucum (L.) R. Br. are documented for the first time as being important in the management of chronic joint pains. Conclusions: The findings of this study show that a variety of medicinal plants are used in the management of chronic joint pains and the main mode of administration is oral. Keywords: Ethnobotanical survey; Medicinal plants; Chronic joint pains; Rheumatoid arthritis; Akamba; Machakos-Kenya
O. DRABUODHASILVESTER. "A Local Approach Methodology for the Analysis of Uncracked Tubular Joints. Journal of Civil Engineering Research and Practise, Volume 1, No. 2, October 2004.". In: East Afr Med J. 1996 Aug;73(8):538-40. The Icfai University Journal of Architecture, Vol. II No.1, February 2010; 2004. Abstract
Between June and December 1992 forty AIDS patients as defined by the CDC criteria, admitted to the medical wards of the Kenyatta National Hospital, were studied to determine the prevalence and pattern of peripheral neuropathy. Their mean age was 33 +/- 3 years with a range of 16 to 55 years. Clinical and laboratory assessment were carried out both to confirm peripheral neuropathy and exclude other causes of peripheral neuropathy apart from AIDS. All the patients had nerve conduction and electromyographic studies done. Eighteen patients were asymptomatic while fourteen had both signs and symptoms. The commonest symptom was painful paresthesiae of the limbs (35%) while the commonest sign was loss of vibration sense (60%). When symptoms, signs, and electrophysiological studies were combined, all the patients fitted the definition of peripheral neuropathy. The commonest type of peripheral neuropathy was distal symmetrical peripheral neuropathy (DSPN) (37.5%). PIP: In Kenya, physicians evaluated 40 AIDS patients admitted to Kenyatta National Hospital during June-December 1992 to determine the prevalence and types of peripheral neuropathy in AIDS patients. 75% were 21-40 years old. 18 (45%) of the 40 AIDS patients had symptoms of peripheral neuropathy. Symptoms included increased sensitivity to stimulation (43%), hyperpathia (15%), and muscle or limb weakness (13%). 26 AIDS patients had signs of peripheral neuropathy, especially impaired sense of vibration (60%). 14 of these patients had both signs and symptoms. Electromyographic and nerve conduction velocity revealed peripheral neuropathy in 16 (40%) AIDS patients. The types of peripheral neuropathy included distal symmetrical peripheral neuropathy (37.5%), polyneuropathy, and mononeuritis multiplex. When the symptoms, signs, and electroneurophysiological test findings were considered, all 40 AIDS patients had evidence of peripheral neuropathy.
JOAB PROFBWAYOJOB, O. PROFANZALAAGGREY. "Long-term survivors in Nairobi: complete HIV-1 RNA sequences and immunogenetic associations. Fang G, Kuiken C, Weiser B, Rowland-Jones S, Plummer F, Chen CH, Kaul R, Anzala AO, Bwayo JJ, Kimani J, Philpott SM, Kitchen C, Sinsheimer JS, Gaschen B, Lang D, .". In: Burger HJ Infect Dis. 2004 Aug 15;190(4):697-701. Asian Economic and Social Society; 2004. Abstract
Background. The host immune response against mucosally-acquired pathogens may be influenced by the mucosal immune milieu during acquisition. Since Neisseria gonorrhoeae can impair dendritic cell and T cell immune function, we hypothesized that co-infection during HIV acquisition would impair subsequent systemic T-cell responses.   Methods. Monthly screening for sexually transmitted infections (STIs) was performed in high risk, HIV seronegative Kenyan female sex workers as part of an HIV prevention trial. Early HIV-specific CD8+ T cell responses and subsequent HIV viral load set point were assayed in participants acquiring HIV, and were correlated with the presence of prior genital infections during HIV acquisition.   Results. Thirty-five participants acquired HIV during follow up, and 16/35 (46%) had a classical STI at the time of acquisition. N. gonorrhoeae co-infection was present during HIV acquisition in 6/35 (17%), and was associated with an increased breadth and magnitude of systemic HIV-specific CD8+ T-cell responses, using both interferon- (IFNg) and MIP-1 beta (MIP1b) as an output. No other genital infections were associated with differences in HIV-specific CD8+ T cell response, and neither N. gonorrhoeae nor other genital infections were associated with differences in HIV plasma viral load at set point.   Conclusion. Unexpectedly, genital N. gonorrhoeae infection during heterosexual HIV acquisition was associated with substantially enhanced HIV-specific CD8+ T-cell responses, although not with differences in HIV viral load set point. This may have implications for the development of mucosal HIV vaccines and adjuvants.
JOAB PROFBWAYOJOB, O. PROFANZALAAGGREY. "Long-term survivors in Nairobi: complete HIV-1 RNA sequences and immunogenetic associations. Fang G, Kuiken C, Weiser B, Rowland-Jones S, Plummer F, Chen CH, Kaul R, Anzala AO, Bwayo JJ, Kimani J, Philpott SM, Kitchen C, Sinsheimer JS, Gaschen B, Lang D, .". In: Burger HJ Infect Dis. 2004 Aug 15;190(4):697-701. John Benjamins Publishing Company; 2004. Abstract
OBJECTIVE: To determine the prevalence of HCV infection and HCV/HIV co-infection among voluntary blood donors at the National Blood Transfusion Centre and clients at the Kenyatta National Hospital HIV-Voluntary Counseling and Testing (VCT) Centre. DESIGN: A prospective cross-sectional descriptive study. SETTING: Kenyatta National Hospital, a tertiary referral and teaching hospital and the National Blood Transfusion Services Centre, Nairobi. SUBJECTS: Volunteer blood donors and VCT attendants. RESULTS: The prevalence of HCV/HIV co-infection among 6154 blood donors in the NBTSC was very low, at 0.02. The HIV prevalence among the 353 KNH HIV-VCT clients was 9.3%, none of the clients tested positive for HCV. The incidence of risk factors in the persons with HCV and/or HIV infection(s) was low. CONCLUSION: The prevalence of HCV infection among pre-screened volunteer blood donors was low. However the current practice of screening all donated blood for HCV remains indispensable to prevent its transmission to blood recipients.
GICHOVI PROFMBOGOHSTEPHEN. "Lucy Ngare's M.Sc. Research and Thesis on the Potential Socio-economic Effects of Adopting Herbicide-coated Maize Seed as a Technology in Striga Weed Control: Student graduated with a Master's Degree in 2004.". In: Nairobi, Catholic University in Eastern Africa, 2002. D.M.Matheka,T.N kiama; 2004. Abstract
Department of Pathology, University of Toronto, Ontario, Canada. Red blood cells and lysate products (erythrolysate) are observed consistently in lymph draining acute and chronic inflammatory reactions and from tissues subjected to trauma or surgical procedures. Using hemoglobin as a marker for erythrolysate, we have measured hemoglobin in lymph up to the 10(-6) M range in a number of pathophysiological states. Data demonstrate that erythrolysate alters the pumping characteristics of lymphatic vessels. To test the effects of erythrolysate on lymphatic pumping, bovine lymphatics were suspended in an organ bath preparation with the vessels cannulated at both inflow and outflow ends. By raising the heights of the Krebs reservoir and the outflow catheters appropriately, a transmural pressure that stimulated pumping activity could be applied to the vessels. With a fixed transmural pressure of 6 cm H2O applied to the ducts, sheep erythrolysate depressed pumping activity between 40% and 100%, with dilutions containing between 10(-8) and 10(-5) M hemoglobin. Although the active principle in the red blood cells has not been characterized, evidence from precipitation purification experiments suggests that hemoglobin is an important component. Once suppressed, pumping could be restored in many but not all vessels (often to control levels) by elevating the distending pressure above 6 cm H2O. The relation between transmural pressure and fluid pumping is expressed as a bell-shaped curve, with pumping increasing up to a peak pressure (usually 8 cm H2O) and declining at pressures above this level. By comparing pressure/flow curves, we were able to ascertain that hemoglobin shifted the lymphatic function curve to the right and, on average, reduced the maximum pumping capability of the vessels. We speculate that the presence of erythrolysate/hemoglobin in lymph may modulate the ability of lymphatic vessels to drain liquid and protein from the tissue spaces.
J DRCHWEYALUDEKI. "Ludeki Chweya, .". In: Proceedings of the Africa Regional Development Policy Forum, 10-11 June 1998, Nairobi, Kenya, 153-164. UNCRD Proceedings Series, No. 29 (Nagoya: United Nations Centre for Regional Development, 1998). ISCTRC; 2004. Abstract
Differentiation of bloodstream-form trypanosomes into procyclic (midgut) forms is an important first step in the establishment of an infection within the tsetse fly. This complex process is mediated by a wide variety of factors, including those associated with the vector itself, the trypanosomes and the bloodmeal. As part of an on-going project in our laboratory, we recently isolated and characterized a bloodmeal-induced molecule with both lectin and trypsin activities from midguts of the tsetse fly, Glossina longipennis [Osir, E.O., Abubakar, L., Imbuga, M.O., 1995. Purification and characterization of a midgut lectin-trypsin complex from the tsetse fly, Glossina longipennis. Parasitol. Res. 81, 276-281]. The protein (lectin-trypsin complex) was found to be capable of stimulating differentiation of bloodstream trypanosomes in vitro. Using polyclonal antibodies to the complex, we screened a G. fuscipes fuscipes cDNA midgut expression library and identified a putative proteolytic lectin gene. The cDNA encodes a putative mature polypeptide with 274 amino acids (designated Glossina proteolytic lectin, Gpl). The deduced amino acid sequence includes a hydrophobic signal peptide and a highly conserved N-terminal sequence motif. The typical features of serine protease trypsin family of proteins found in the sequence include the His/Asp/Ser active site triad with the conserved residues surrounding it, three pairs of cysteine residues for disulfide bridges and an aspartate residue at the specificity pocket. Expression of the gene in a bacterial expression system yielded a protein (M(r) approximately 32,500). The recombinant protein (Gpl) bound d(+) glucosamine and agglutinated bloodstream-form trypanosomes and rabbit red blood cells. In addition, the protein was found to be capable of inducing transformation of bloodstream-form trypanosomes into procyclic forms in vitro. Antibodies raised against the recombinant protein showed cross-reactivity with the alpha subunit of the lectin-trypsin complex. These results support our earlier hypothesis that this molecule is involved in the establishment of trypanosome infections in tsetse flies.
N PROFLULEGODFREY. "Lule GN.Spontaneous bacterial peritonitis. East Afr Med J. 2004 Mar;81(3):113. Review. No abstract available.". In: East Afr Med J. 2005 Apr;82(4):166-9. test; 2004. Abstract

OBJECTIVE: To determine the prevalence of HCV infection and HCV/HIV co-infection among voluntary blood donors at the National Blood Transfusion Centre and clients at the Kenyatta National Hospital HIV-Voluntary Counseling and Testing (VCT) Centre. DESIGN: A prospective cross-sectional descriptive study. SETTING: Kenyatta National Hospital, a tertiary referral and teaching hospital and the National Blood Transfusion Services Centre, Nairobi. SUBJECTS: Volunteer blood donors and VCT attendants. RESULTS: The prevalence of HCV/HIV co-infection among 6154 blood donors in the NBTSC was very low, at 0.02. The HIV prevalence among the 353 KNH HIV-VCT clients was 9.3%, none of the clients tested positive for HCV. The incidence of risk factors in the persons with HCV and/or HIV infection(s) was low. CONCLUSION: The prevalence of HCV infection among pre-screened volunteer blood donors was low. However the current practice of screening all donated blood for HCV remains indispensable to prevent its transmission to blood recipients.

B. PROFESTAMBALEBENSON. "Luoba AI, Geissler PW, Estambale B, Ouma JH, Magnussen P, Alusala D, Ayah R, Mwaniki D, Friis H. Geophagy among pregnant and lactating women in Bondo District, western Kenya. Trans R Soc Trop Med Hyg. 2004 Dec;98(12):734-41.". In: Trans R Soc Trop Med Hyg. 2004 Dec;98(12):734-41. Taylor & Francis; 2004. Abstract
Geophagy was studied among 827 pregnant women in western Kenya, during and after pregnancy. The women were recruited at a gestational age of 14-24 weeks and followed-up to 6 months post-partum. The median age (range) of the women was 23 years and median parity 2. At recruitment, 378 were eating earth, of which most (65%) reported earth-eating before pregnancy. The preferred type of earth eaten was soft stone, known locally as odowa (54.2%) and earth from termite mounds (42.8%). The prevalence remained high during pregnancy, and then declined to 34.5% and 29.6% at 3 and 6 months post-partum respectively (P < 0.001). The mean daily earth intake was 44.5 g during pregnancy, which declined to 25.5 g during lactation (P < 0.001). A random sample of 204 stools was collected from the women and analysed for silica content as a tracer for earth-eating. The mean silica content was 2.1% of the dry weight of stool. Geophagous women had a higher mean silica content than the non-geophagous ones (3.1% vs. 1.4%, P < 0.001). Faecal silica and reported geophagy were strongly correlated (P < 0.001).
Dorothy McCormick. "Labour and the Paradox of Flexibility.". In: "Labour and the Paradox of Flexibility: The Case of Micro and Small Garment and Metal Enterprises in Nairobi." Paper presented at Mzumbe University/Adger University College International Conference on Research for Development,26-28. Mzumbe University/Adger University College: Cambridge: Cambridge University Press.; 2003. Abstract

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O. PROFNDINYA-ACHOLAJ. "Lavreys L, Ashley R, Chohan B, Richardson BA, Corey L, Mandaliya K, Ndinya-Achola JO, Kreiss JK. Human herpesvirus type 8: Seroprevalence and correlates in prostitutes in Mombasa, Kenya. J Infect Dis 2003; 187:359-363.". In: J Infect Dis 2003; 187:359-363. IBIMA Publishing; 2003. Abstract
Human herpesvirus 8 (HHV-8) infection is very prevalent in sub-Saharan Africa, but the role of sexual transmission has not been well characterized. HHV-8 seroprevalence and correlates were evaluated in a cohort of female prostitutes in Mombasa, Kenya. Between February 1993 and January 2000, stored plasma samples taken from 736 women were tested, by whole-virus ELISA assay, for the presence of HHV-8 antibodies; of these 736 women, 633 were included in the analysis of correlates of HHV-8 infection; and, of these 633, 44.1% were seropositive for HHV-8 antibodies. In univariate analysis, age, years of education, years of prostitution, workplace, hormonal contraception, intrauterine-device use, alcohol consumption, syphilis, and gonorrhea were all significantly associated with the presence of HHV-8 antibodies. In a multivariate model, older age, fewer years of education, and 2 markers of high-risk sexual behavior-namely, alcohol consumption and gonorrhea-were each independently associated with HHV-8 seropositivity. These results suggest that heterosexual transmission may contribute to acquisition of HHV-8 infections in this African population of prostitutes.
Ogada, Mordecai O. WONRO, Frank LG. "Limiting depredation by African carnivores: The role of livestock husbandry." Conservation Biology 17 (6): 1521-1530; 2003. Abstract
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K DRMBURUMARYWAMBUI. "Line-planted trees and phosphorus effects on maize water use in sub-humid western Kenya. East African Agriculture and Forestry Journal. 69:173-182.". In: Proceedings of 19th Soil Science Society of East AfricaConference,2-7 2001, Moshi, Tanzania. Pp 1-13. University of Nairobi; 2003. Abstract
Kent papers in POlitics and International Relations, Series 4, No. 4.
O DRACHIATHOMASN. "Linear Estimation of Standard deviation of Logistic Distribution.". In: Theory and Algorithms in InterStat. John Benjamins Publishing Company; 2003. Abstract
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KAHIU DRNGUGIELIUD. "Locating Quantitative Trait Loci for maize stem borer resistance in Kenya through molecular markers. African Journal of Crop Science.". In: Journal of Crop Science and Biotechnology. Korean Society of Crop Science and Springer; 2003. Abstract
Objective: To determine the prevalence and pattern of eye diseases and visual impairment in the Nairobi Comprehensive Eye Care Services (NCES) Project; the catchment area of the Mbagathi District Eye Unit of Nairobi. Design: Community based survey conducted from October 15th to 31st 2007 Setting: Kibera and Dagoreti divisions of Nairobi City Subjects: 4200 people of all ages were randomly selected; 4056 were examined (96.6% response rate). 122 (2.9%) were not available and 15 (0.4%) declined to be examined. Results: Females: 54.2%, Males: 45.8%. Mean age; 22.4 years, SD; 16.5. Only 241(5.9%) aged >50years old. The leading eye disorders in Kibera and Dagoretti divisions are conjunctival disorders including allergic conjunctivitis and conjunctival growths. This was found to affect 7.6% of the subjects. This was followed by refractive errors found in 5.3% of the subjects. Cataract was found in 30 subjects (0.7%). Disorders of the retina and the optic nerve were found in 1.1% of the subjects and corneal disorders in 0.5%. The prevalence of visual impairment was 0.6%, severe visual impairment was 0.05% and blindness was 0.1%. This indicates that most of the ocular disorders encountered were not visually threatening. The main cause of visual impairment is refractive errors and the causes of severe visual impairment and blindness are cataract, corneal opacity and glaucoma. Conclusion: The population of the NCES is relatively young and the prevalence of blindness and visual impairment is low. The main cause of visual impairment was refractive errors and the causes of severe visual impairment and blindness were cataract, corneal opacity and glaucoma. Recommendations: The level of blindness in NCES is low and the project should focus more on rendering eye care and not treatment of blindness. There is need to address the issue of refractive errors as this was one of the main ocular problems encountered. In this survey, it was not possible to perform detailed refraction and hence it was recommend that a refractive error survey be conducted; especially in school going children.
MBORI- PROFNGACHADOROTHYA, ELIZABETH DROBIMBO. "Lohman B, Slyker J, Mbori-Ngacha D, Bosire R, Farquhar C, Obimbo E, Otieno P, Nduati R, Rowland-Jones S, John-Stewart G. Prevalence and Magnitude of HIV-1-specific Lymphocyte Responses in Breast Milk from HIV-1 Seropositive Women. J Infect Dis. 2003:188:1.". In: J Infect Dis. 2003:188:1666-1674. Kisipan, M.L.; 2003. Abstract
Department of Medical Microbiology, University of Nairobi, Kenya. Human immunodeficiency virus (HIV) type 1-specific cell-mediated immunity of breast milk may influence the likelihood of mother-to-child transmission of HIV-1 via breast-feeding. In breast-milk specimens collected during the first month postpartum from HIV-1-seropositive women in Nairobi, HIV-1 gag-specific cellular responses were detected in 17 (47%) of 36, and env-specific cellular responses were present in 20 (40%) of 50. Peripheral blood lymphocyte responses against either gag or env were detected in 35 (66%) of the 53 subjects, 18 (51%) of whom had positive gag or env responses in their breast milk. In paired analyses of blood and breast milk, the mean magnitude of responses to env or gag stimulation in breast milk was significantly higher than that in blood and remained higher in breast milk after normalization of responses according to CD8+ lymphocyte count. These results suggest that CD8+ lymphocytes present in breast milk have the capacity to recognize HIV-1-infected cells and may be selectively transported to breast milk to reduce either viral replication or transmission in breast milk.
MBORI- PROFNGACHADOROTHYA, ELIZABETH DROBIMBO. "Lohman B, Slyker J, Mbori-Ngacha D, Bosire R, Farquhar C, Obimbo E, Otieno P, Nduati R, Rowland-Jones S, John-Stewart G. Prevalence and Magnitude of HIV-1-specific Lymphocyte Responses in Breast Milk from HIV-1 Seropositive Women. J Infect Dis. 2003:188:1.". In: J Infect Dis. 2003:188:1666-1674. Earthscan, London. 978-1-84407-469-3 (*); 2003. Abstract
Department of Medical Microbiology, University of Nairobi, Kenya. Human immunodeficiency virus (HIV) type 1-specific cell-mediated immunity of breast milk may influence the likelihood of mother-to-child transmission of HIV-1 via breast-feeding. In breast-milk specimens collected during the first month postpartum from HIV-1-seropositive women in Nairobi, HIV-1 gag-specific cellular responses were detected in 17 (47%) of 36, and env-specific cellular responses were present in 20 (40%) of 50. Peripheral blood lymphocyte responses against either gag or env were detected in 35 (66%) of the 53 subjects, 18 (51%) of whom had positive gag or env responses in their breast milk. In paired analyses of blood and breast milk, the mean magnitude of responses to env or gag stimulation in breast milk was significantly higher than that in blood and remained higher in breast milk after normalization of responses according to CD8+ lymphocyte count. These results suggest that CD8+ lymphocytes present in breast milk have the capacity to recognize HIV-1-infected cells and may be selectively transported to breast milk to reduce either viral replication or transmission in breast milk.
MBORI- PROFNGACHADOROTHYA, ELIZABETH DROBIMBO. "Lohman B, Slyker J, Mbori-Ngacha D, Bosire R, Farquhar C, Obimbo E., Otieno P, Nduati R, Rowland-Jones S, John-Stewart G. Prevalence and Magnitude of HIV-1-specific Lymphocyte Responses in Breast Milk from HIV-1 Seropositive Women. J. Infect Dis. Dec 2003.". In: J. Infect Dis. Dec 2003; 1888 (11) 1999-74. Kisipan, M.L.; 2003. Abstract
Department of Medical Microbiology, University of Nairobi, Kenya. Human immunodeficiency virus (HIV) type 1-specific cell-mediated immunity of breast milk may influence the likelihood of mother-to-child transmission of HIV-1 via breast-feeding. In breast-milk specimens collected during the first month postpartum from HIV-1-seropositive women in Nairobi, HIV-1 gag-specific cellular responses were detected in 17 (47%) of 36, and env-specific cellular responses were present in 20 (40%) of 50. Peripheral blood lymphocyte responses against either gag or env were detected in 35 (66%) of the 53 subjects, 18 (51%) of whom had positive gag or env responses in their breast milk. In paired analyses of blood and breast milk, the mean magnitude of responses to env or gag stimulation in breast milk was significantly higher than that in blood and remained higher in breast milk after normalization of responses according to CD8+ lymphocyte count. These results suggest that CD8+ lymphocytes present in breast milk have the capacity to recognize HIV-1-infected cells and may be selectively transported to breast milk to reduce either viral replication or transmission in breast milk.
MBORI- PROFNGACHADOROTHYA, ELIZABETH DROBIMBO. "Lohman B, Slyker J, Mbori-Ngacha D, Bosire R, Farquhar C, Obimbo E., Otieno P, Nduati R, Rowland-Jones S, John-Stewart G. Prevalence and Magnitude of HIV-1-specific Lymphocyte Responses in Breast Milk from HIV-1 Seropositive Women. J. Infect Dis. Dec 2003.". In: J. Infect Dis. Dec 2003; 1888 (11) 1999-74. Earthscan, London. 978-1-84407-469-3 (*); 2003. Abstract
Department of Medical Microbiology, University of Nairobi, Kenya. Human immunodeficiency virus (HIV) type 1-specific cell-mediated immunity of breast milk may influence the likelihood of mother-to-child transmission of HIV-1 via breast-feeding. In breast-milk specimens collected during the first month postpartum from HIV-1-seropositive women in Nairobi, HIV-1 gag-specific cellular responses were detected in 17 (47%) of 36, and env-specific cellular responses were present in 20 (40%) of 50. Peripheral blood lymphocyte responses against either gag or env were detected in 35 (66%) of the 53 subjects, 18 (51%) of whom had positive gag or env responses in their breast milk. In paired analyses of blood and breast milk, the mean magnitude of responses to env or gag stimulation in breast milk was significantly higher than that in blood and remained higher in breast milk after normalization of responses according to CD8+ lymphocyte count. These results suggest that CD8+ lymphocytes present in breast milk have the capacity to recognize HIV-1-infected cells and may be selectively transported to breast milk to reduce either viral replication or transmission in breast milk.
MBORI- PROFNGACHADOROTHYA, W. PROFNDUATIRUTH. "Longitudinal analysis of human immunodeficiency virus type 1 RNA in breast milk and of its relationship to infant infection and maternal disease. Rousseau CM, Nduati RW, Richardson BA, Steele MS, John-Stewart GC, Mbori-Ngacha DA, Kreiss JK, Overbaugh J.". In: J Infect Dis. 2003 Mar 1;187(5):741-7. Epub 2003 Feb 18. Journal of School of Continuous and Distance Education ; 2003. Abstract
Transmission of human immunodeficiency virus type 1 (HIV-1) via breast-feeding can occur throughout lactation. Defining both fluctuation in breast-milk virus level over time and how breast-milk virus correlates with mother-to-child transmission is important for establishing effective interventions. We quantified breast-milk HIV-1 RNA levels in serial samples collected from 275 women for up to 2 years after delivery. Higher maternal plasma virus load, lower maternal CD4 T cell count, and detection of HIV-1 DNA in maternal genital secretions were significantly associated with elevated breast-milk HIV-1 RNA. Within women who breast-fed, median virus load in colostrum/early milk was significantly higher than that in mature breast milk collected 14 days after delivery (P< or =.004). Breast-feeding mothers who transmitted HIV-1 to their infants had both significantly higher breast-milk viral RNA throughout lactation and more-consistent viral shedding, compared with mothers who did not transmit HIV-1. In breast-feeding women, a 2-fold-increased risk of transmission was associated with every 10-fold increase in breast-milk virus load (95% confidence interval, 1.3-3.0; P<.001). These results indicate that the risk of infant infection from breast-feeding is influenced by breast-milk virus load, which is highest early after delivery.
MBORI- PROFNGACHADOROTHYA, W. PROFNDUATIRUTH. "Longitudinal analysis of human immunodeficiency virus type 1 RNA in breast milk and of its relationship to infant infection and maternal disease. Rousseau CM, Nduati RW, Richardson BA, Steele MS, John-Stewart GC, Mbori-Ngacha DA, Kreiss JK, Overbaugh J.". In: J Infect Dis. 2003 Mar 1;187(5):741-7. Epub 2003 Feb 18. Earthscan, London. 978-1-84407-469-3 (*); 2003. Abstract
Transmission of human immunodeficiency virus type 1 (HIV-1) via breast-feeding can occur throughout lactation. Defining both fluctuation in breast-milk virus level over time and how breast-milk virus correlates with mother-to-child transmission is important for establishing effective interventions. We quantified breast-milk HIV-1 RNA levels in serial samples collected from 275 women for up to 2 years after delivery. Higher maternal plasma virus load, lower maternal CD4 T cell count, and detection of HIV-1 DNA in maternal genital secretions were significantly associated with elevated breast-milk HIV-1 RNA. Within women who breast-fed, median virus load in colostrum/early milk was significantly higher than that in mature breast milk collected 14 days after delivery (P< or =.004). Breast-feeding mothers who transmitted HIV-1 to their infants had both significantly higher breast-milk viral RNA throughout lactation and more-consistent viral shedding, compared with mothers who did not transmit HIV-1. In breast-feeding women, a 2-fold-increased risk of transmission was associated with every 10-fold increase in breast-milk virus load (95% confidence interval, 1.3-3.0; P<.001). These results indicate that the risk of infant infection from breast-feeding is influenced by breast-milk virus load, which is highest early after delivery.
PAUL PROFBAKI. "Lorentz- Non-invariance Effect on Flavour Oscillations, General Relativity and Gravitation.". In: Vol. 35, 891(2003). Heinrich Boll Foundation.; 2003.
Otieno AC. "LINE-1 preTa element in the human genome.". In: 13th International Symposium on Human Identification. Phoenix , Arizona; 2002.
and S. H. Ambrose, L. J. Hlusko KDWMDAM. "Lemudong’o: A late Miocene fossil site in southern Kenya.". In: 71st Annual Meeting of the American Association of Physical Anthropologists. Buffalo, New York, USA ; 2002.
Dorothy McCormick. "Linkages between Small and Large Firms in the Kenyan Food Processing Sector.". In: Innovation and Small Enterprises in the Third World. Cambridge: Cambridge University Press.; 2002. Abstract

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P. PROFMUREITHILEOPOLD. ""Labour Market Flexibility and Employment in Africa: Mixed Outcomes". Paper written for WB-FES-ILO/ACTRAV Capacity Building Seminar on Poverty Reduction Strategy Papers - PRSP (Lusaka).". In: Gabbay R. &Siddique A., ed., Good Governance Issues and Sustainable Development: The Indian Ocean Region (New Delhi: Vedams Books). ISCTRC; 2002. Abstract
Differentiation of bloodstream-form trypanosomes into procyclic (midgut) forms is an important first step in the establishment of an infection within the tsetse fly. This complex process is mediated by a wide variety of factors, including those associated with the vector itself, the trypanosomes and the bloodmeal. As part of an on-going project in our laboratory, we recently isolated and characterized a bloodmeal-induced molecule with both lectin and trypsin activities from midguts of the tsetse fly, Glossina longipennis [Osir, E.O., Abubakar, L., Imbuga, M.O., 1995. Purification and characterization of a midgut lectin-trypsin complex from the tsetse fly, Glossina longipennis. Parasitol. Res. 81, 276-281]. The protein (lectin-trypsin complex) was found to be capable of stimulating differentiation of bloodstream trypanosomes in vitro. Using polyclonal antibodies to the complex, we screened a G. fuscipes fuscipes cDNA midgut expression library and identified a putative proteolytic lectin gene. The cDNA encodes a putative mature polypeptide with 274 amino acids (designated Glossina proteolytic lectin, Gpl). The deduced amino acid sequence includes a hydrophobic signal peptide and a highly conserved N-terminal sequence motif. The typical features of serine protease trypsin family of proteins found in the sequence include the His/Asp/Ser active site triad with the conserved residues surrounding it, three pairs of cysteine residues for disulfide bridges and an aspartate residue at the specificity pocket. Expression of the gene in a bacterial expression system yielded a protein (M(r) approximately 32,500). The recombinant protein (Gpl) bound d(+) glucosamine and agglutinated bloodstream-form trypanosomes and rabbit red blood cells. In addition, the protein was found to be capable of inducing transformation of bloodstream-form trypanosomes into procyclic forms in vitro. Antibodies raised against the recombinant protein showed cross-reactivity with the alpha subunit of the lectin-trypsin complex. These results support our earlier hypothesis that this molecule is involved in the establishment of trypanosome infections in tsetse flies.
P. PROFMUREITHILEOPOLD. "Labour Market Flexity and Employment in Africa.". In: Gabbay R. &Siddique A., ed., Good Governance Issues and Sustainable Development: The Indian Ocean Region (New Delhi: Vedams Books). ISCTRC; 2002. Abstract
Differentiation of bloodstream-form trypanosomes into procyclic (midgut) forms is an important first step in the establishment of an infection within the tsetse fly. This complex process is mediated by a wide variety of factors, including those associated with the vector itself, the trypanosomes and the bloodmeal. As part of an on-going project in our laboratory, we recently isolated and characterized a bloodmeal-induced molecule with both lectin and trypsin activities from midguts of the tsetse fly, Glossina longipennis [Osir, E.O., Abubakar, L., Imbuga, M.O., 1995. Purification and characterization of a midgut lectin-trypsin complex from the tsetse fly, Glossina longipennis. Parasitol. Res. 81, 276-281]. The protein (lectin-trypsin complex) was found to be capable of stimulating differentiation of bloodstream trypanosomes in vitro. Using polyclonal antibodies to the complex, we screened a G. fuscipes fuscipes cDNA midgut expression library and identified a putative proteolytic lectin gene. The cDNA encodes a putative mature polypeptide with 274 amino acids (designated Glossina proteolytic lectin, Gpl). The deduced amino acid sequence includes a hydrophobic signal peptide and a highly conserved N-terminal sequence motif. The typical features of serine protease trypsin family of proteins found in the sequence include the His/Asp/Ser active site triad with the conserved residues surrounding it, three pairs of cysteine residues for disulfide bridges and an aspartate residue at the specificity pocket. Expression of the gene in a bacterial expression system yielded a protein (M(r) approximately 32,500). The recombinant protein (Gpl) bound d(+) glucosamine and agglutinated bloodstream-form trypanosomes and rabbit red blood cells. In addition, the protein was found to be capable of inducing transformation of bloodstream-form trypanosomes into procyclic forms in vitro. Antibodies raised against the recombinant protein showed cross-reactivity with the alpha subunit of the lectin-trypsin complex. These results support our earlier hypothesis that this molecule is involved in the establishment of trypanosome infections in tsetse flies.
OKOTH PROFOGENDOHASTINGW. ""Land Administration: the Neglected factor in land reform in Africa", paper for the world Bank Regional Workshop on Land issues in Africa and the Middle East, held in Kampala, Uganda, april 29 - May 2.". In: Cent. Afri. J. Pharm.Sci. 5(3): 60-66. Cent. Afri. J. Pharm.Sci. 5(3): 60-66; 2002. Abstract
The identification of five novel compounds, pseudo-erythromycin A-6,9-hemiketal, 8,9-anhydro-pseudo-erythromycin A-6,9-hemiketal, 8,9-anhydro-pseudo-N-demethylerythromycin A-6,9-hemiketal, 5-O-beta-D-desosaminylerythronolide A and 15-nor-erythromycin C, in mother liquor concentrates of Streptomyces erythraeus is described. The pseudo-erythromycin derivatives are characterized by a 12-membered macrocyclic ring as a result of C13––C11 trans-lactonization. The five compounds have very little antimicrobial activity.
OKOTH PROFOGENDOHASTINGW. ""Land Tenure Reform in Africa: Lessons from East Africa", paper for the symposium on communal Land Tenure Reform, held in Johannesburg, south Africa, August 12-13.". In: Cent. Afri. J. Pharm.Sci. 5(3): 60-66. Cent. Afri. J. Pharm.Sci. 5(3): 60-66; 2002. Abstract
The identification of five novel compounds, pseudo-erythromycin A-6,9-hemiketal, 8,9-anhydro-pseudo-erythromycin A-6,9-hemiketal, 8,9-anhydro-pseudo-N-demethylerythromycin A-6,9-hemiketal, 5-O-beta-D-desosaminylerythronolide A and 15-nor-erythromycin C, in mother liquor concentrates of Streptomyces erythraeus is described. The pseudo-erythromycin derivatives are characterized by a 12-membered macrocyclic ring as a result of C13––C11 trans-lactonization. The five compounds have very little antimicrobial activity.
N. DREKAYAWELLINGTON. "Land use and spatial distribution of two gum and incense producing tree species in the Blue-nile valley of Wogidi district, Ethiopia. Journal of Human Ecology, 14:77- 87.". In: African Journal of Range and Forage Science (2003) 20(3): 265-270. ARCHWAY Technology Management Ltd; 2002. Abstract
Fifteen yearling goats with similar weight were used to evaluate the potential of Zizyphus spina-christi leaves as a supplement to goats fed on Cynodon dactylon grass. Animals were randomly assigned to five feeding regimes and individually stall-fed for a preliminary period of 14 days, followed by 14 days of feeding to determine dry matter intake and digestibility, and a 3-month  feeding period to determine body weight changes. The treatments were formulated based on leaf: grass ratios of 0%, 25%, 50%, 75%, and 100%. Z. spina-christi leaves had higher crude protein and lower fibre content than C. dactylon grass (P<0.05). Dry matter intake, digestibility and body weight changes increased significantly (P < 0.05) as the level of supplementation increased. Thus, Z. spina-christi foliage is a potential feed supplement in the dry season, as the dry season grasses are deficient in the required nutrients and cannot meet goat requirements
KIIRU PROFMUCHUGUDH. "A Latter-Day Eve,Mwangaza 2.2 (July 2002):49.". In: The Nairobi Journal of Literature 1 (March 2003): 15-22. Philosophical Issues Invoked by Shona People; 2002. Abstract

Borrowing its title from William Shakespeare's King Lear, this article examines some aesthetic and cognitive characteristics of some indigenous ethnic myths in Kenya as a subgenre of the oral narrative. The article asserts that human beings create the myth to help them make sense of human existence

O. PROFNDINYA-ACHOLAJ. "Lavreys L, Baeten J, Overbaugh J, Patelleef DD, Chohan B, Richardson B, Mandaliya K, Ndinya-Achola J, Kreiss J. Acute HIV-1 infection illness in Kenyan women is associated with higher viral loads. Clin Infect Dis 2002;35:77-81.". In: Clin Infect Dis 2002;35:77-81. IBIMA Publishing; 2002. Abstract
{ Observational studies have associated vitamin A deficiency with vaginal shedding of human immunodeficiency virus (HIV) type 1-infected cells and mother-to-child HIV-1 transmission. To assess the effect of vitamin A supplementation on vaginal shedding of HIV-1, a randomized, double-blind, placebo-controlled trial of 6 weeks of daily oral vitamin A (10,000 IU of retinyl palmitate) was conducted among 400 HIV-1-infected women in Mombasa, Kenya. At follow-up, there was no statistically significant difference in the prevalence of HIV-1 DNA (18% vs. 21%
O. PROFNDINYA-ACHOLAJ. "Lavreys L, Baeten JM, Overbaugh J, Panteleeff DD, Chohan BH, Richardson BA, Mandaliya K, Ndinya-Achola JO, Kreiss JK.Virus load during primary Human Immunodeficiency Virus (HIV) type 1 infection is related to the severity of acute HIV illness in Kenyan wo.". In: Clin Infect Dis. 2002 Jul 1;35(1):77-81. Epub 2002 Jun 3. IBIMA Publishing; 2002. Abstract
We evaluated the association between the severity of primary human immunodeficiency virus type 1 (HIV-1) illness and HIV-1 plasma virus load before seroconversion using stored plasma samples obtained from 74 prostitutes in Mombasa, Kenya. Fever, vomiting, headache, fatigue, arthralgia, myalgia, sore throat, skin rash, or being too sick to work were each associated with significantly higher virus loads before HIV-1 seroconversion, and each additional symptom or sign was associated with an increase in virus load of 0.4 log(10) copies/mL.
OGEDA MRODUMBEJACKONIAH. "Learner, Curriculum and Syllabus Course Outline and the Institution.". In: Seminar on African University Day of UNISWA 15th November 2002. Thought and Practice; 2002. Abstract
Introduction The Centre for Open and Distance Learning has been established to facilitate the Internal Faculties in launching and managing their programmes using distance mode with a view to increasing access to university education and provide equity in higher education to the learners all over the country. Operational Strategies The operational strategies that have been set up involve collaborative arrangements between the CODL and the Internal Faculties in the development of Study Materials and Learner support Services for off-campus students. The professional in open and distance learning are availed by the Centre to serve the Faculties as trainers while the Faculties provide academic expertise who are facilitated through participatory methods involving application of knowledge, skills and strategies to develop study materials in their respective subjects. Focus The Centre is currently working with Faculties of Science, Commerce and Arts. The Material development process involves training, writing, reviewing and editing followed by conversion to e-content and audio modes. Conclusion These collaborative arrangements will increase access to higher education make significant contribution in the realization of educational Millennium Goals in Kenya where only 20% of all those who qualify obtain admission in the public universities.
K DRMBURUMARYWAMBUI, S PROFIGONSANGWASHIBAIRO. "Light and Water Use in Low Input Maize (Zea mays)- Pigeonpea (Cajanus cajan) Intercrop in Sub Humid Conditions of Kenya.". In: Poster presented at the fifth Regional meeting of the Forum for Agricultural Resource Husbandry 12-16 August 2002,Entebbe. University of Nairobi; 2002. Abstract
Kent papers in POlitics and International Relations, Series 4, No. 4.
K DRMBURUMARYWAMBUI, S PROFIGONSANGWASHIBAIRO. "Light and Water Use in Low Input Maize (Zea mays)- Pigeonpea (Cajanus cajan) Intercrop in Sub Humid Conditions of Kenya.". In: Poster presented at the fifth Regional meeting of the Forum for Agricultural Resource Husbandry 12-16 August 2002,Entebbe. Taylor & Francis; 2002. Abstract
Normal 0 false false false MicrosoftInternetExplorer4 st1:*{behavior:url(#ieooui) } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} Hepatocellular carcinoma results when cancerous cells are localized in the liver. It is distributed globally with high prevalence in sub-Saharan African, southern Asia, China and Japan. Diagnosis is experimental and in many cases inaccurate due to unreliability of markers. Prognosis is poor and the cost of treatment prohibitive. Conventional radiation and chemotherapy lead to loss of hair, fertility and general weakening of the body`s immune system increasing a patient`s risk to infection. These observations underscore the need for improved, or additional methods of cancer diagnosis and management. We investigated the effect of polysaccharide rich Pleurotus pulmonarius fruit body extracts on progression of chemically induced hepatocellular carcinoma in CBA mice. Addition of Pleurotus pulmonarius extracts in diet delayed progression of carcinogenesis suggesting   that these extracts may be useful as   adjuvants to conventional cancer therapies.   Key words: carcinogenesis; mice; mushroom extracts; pleurotus pulmunarius   Corresponding author: Ms Carolyne Wasonga, Department of Biochemistry, University of Nairobi, P.O. Box 30197, Nairobi,  Kenya. E-mail: carox27@yahoo.ca     Charles O.A. Omwandho, Susanne E. Gruessner, John Falconer, Hans-R Tinneberg, Timothy K. Roberts. IS OVINE PLACENTAL IGG TOXIC TO HUMAN PERIPHERAL BLOOD NATURAL KILLER CELLS?
ROSEMARY DRATIENO. ""Linkages between Small and Large Firms in the Kenyan Food Processing Sector" with Dorothy McCormick. In Van Dijk M.P. and H. Sandee (eds). Innovation and Small Enterprises in the Third World. Edward Elgar Publishing.". In: Innovation and Small Enterprises in the Third World. Edward Elgar Publishing. Journal of School of Continuous and Distance Education ; 2002.
OCHIENG PROFDIGOLOPATRICKOBONYO. "Literacy in Kenya in the 21st Century. Eastern Africa Journal of Humanities and Sciences, Vol. 2, No. 1. January 2002. Pp. 24 .". In: Eastern Africa Journal of Humanities and Sciences, Vol. 2, No. 1. January 2002. Pp. 24 . Philosophical Issues Invoked by Shona People; 2002. Abstract
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N PROFLULEGODFREY, OLONDE PROFAMAYOERASTUS. "Lule GN, Amayo EO. Irritable bowel syndrome in Kenyans. East Afr Med J. 2002 Jul;79(7):360-3.". In: East Afr Med J. 2002 Jul;79(7):360-3. African Wildlife Foundation. Nairobi; 2002. Abstract

OBJECTIVE: To study the prevalence and clinical presentation of irritable bowel syndrome (IBS) in black Kenyans. DESIGN: A retrospective study. SETTING: Nairobi Hospital, an urban private institution. SUBJECTS: Case files of all patients presenting with abdominal pain. MAIN OUTCOME MEASURES: Prevalence of IBS using modified Manning's Symptomatic criteria in 223 consecutive adult patients presenting with abdominal pain and discomfort who had normal clinical findings and normal general and gastrointestinal investigations. RESULTS: Out of the 3472 patient files screened, there were 281 patients who fitted the diagnosis of irritable bowel syndrome giving an overall prevalence of 8%. The mean age was 40 years with range of 11 to 75 years with a peak prevalence in the 3rd decade. The male to female ratio of 1.4:1 being statistical significant at a p-value of 0.010. There was no statistical significant difference between the males and females in constipation and diarrhoea at p-value of 0.84 and 0.82 respectively. Fifteen percent of the patients were either on antidepressants or had been seen by a psychiatrist. Nine percent had undergone laparatomy for the abdominal pain. CONCLUSION: The Black African patient is equally as exposed to irritable bowel syndrome as is his counterpart in the western world and has similar morbidity patterns. The syndrome may account for over 10% of patients with abdominal pain presenting to gastroenterologists in Africa. Proper attention to symptomatology may lead to clinching the diagnosis without resorting to many unnecessary and expensive investigations.

N PROFLULEGODFREY, OLONDE PROFAMAYOERASTUS. "Lule GN, Amayo EO. Irritable bowel syndrome in Kenyans. East Afr Med J. 2002 Jul;79(7):360-3.". In: East Afr Med J. 2002 Jul;79(7):360-3. test; 2002. Abstract

OBJECTIVE: To study the prevalence and clinical presentation of irritable bowel syndrome (IBS) in black Kenyans. DESIGN: A retrospective study. SETTING: Nairobi Hospital, an urban private institution. SUBJECTS: Case files of all patients presenting with abdominal pain. MAIN OUTCOME MEASURES: Prevalence of IBS using modified Manning's Symptomatic criteria in 223 consecutive adult patients presenting with abdominal pain and discomfort who had normal clinical findings and normal general and gastrointestinal investigations. RESULTS: Out of the 3472 patient files screened, there were 281 patients who fitted the diagnosis of irritable bowel syndrome giving an overall prevalence of 8%. The mean age was 40 years with range of 11 to 75 years with a peak prevalence in the 3rd decade. The male to female ratio of 1.4:1 being statistical significant at a p-value of 0.010. There was no statistical significant difference between the males and females in constipation and diarrhoea at p-value of 0.84 and 0.82 respectively. Fifteen percent of the patients were either on antidepressants or had been seen by a psychiatrist. Nine percent had undergone laparatomy for the abdominal pain. CONCLUSION: The Black African patient is equally as exposed to irritable bowel syndrome as is his counterpart in the western world and has similar morbidity patterns. The syndrome may account for over 10% of patients with abdominal pain presenting to gastroenterologists in Africa. Proper attention to symptomatology may lead to clinching the diagnosis without resorting to many unnecessary and expensive investigations.

O. PROFNDINYA-ACHOLAJ. "Luo M, Embree J, Ramdahin S, Ndinya-Achola J, Njenga S, Bwayo JB, Pan S, Mao X, Cheang M, Stuart T, Brunham RC, Plummer FA.HLA-A and HLA-B in Kenya, Africa: allele frequencies and identification of HLA-B*1567 and HLA-B*4426.Tissue Antigens. 2002 May;59(5).". In: Tissue Antigens. 2002 May;59(5):370-80. IBIMA Publishing; 2002. Abstract
HLA-A and HLA-B alleles of a population from Kenya, Africa were examined by sequencing exon 2 and exon 3 DNA and typing using a Taxonomy-based Sequence-analysis (TBSA) method. Extensive diversities were observed at both HLA-A and HLA-B loci in this population. Forty-one HLA-A alleles were identified from 159 unrelated individuals. The most frequently observed alleles were A*6802 (11.64%), A*02011/09 (9.75%), A*7401/02 (9.43%), A*3001 (7.86%), A*3002 (7.23%) and A*3601 (6.6%). Forty-nine HLA-B alleles were identified in 161 unrelated individuals, including two novel alleles, B*1567 and B*4426. The most frequently observed HLA-B alleles were B*5301 (9.01%), B*5801 (8.38%), B*4201 (7.76%), B*1503 (7.14%), B*1801 (6.21%), and B*5802 (5.90%). The most frequently observed HLA-A-B haplotypes were A*3601-B*5301 (3.55%) and A*3001-B*4201 (3.19%), followed by A*7401/02-B*5801 (2.84%), A*7401/02-B*5802 (2.84%) and A*02011/09-B*1503 (2.13%). Linkage disequilibrium and chi2 analysis showed the association of these HLA-A-B haplotypes at the antigen level to be significant. The frequencies of HLA-A and HLA-B alleles from the Kenyan population were compared with that of a population from Cameroon. The difference in allele and haplotype frequency distributions partly reflected the different ethnic composition of these two African populations.
M. PROFLUTIFELIX. "Luti, F.M. (2002). Fundamentals of Engineering Thermodynamics, University of Nairobi Press, Nairobi, ISBN 9966846530, 385 pp.". In: East Afr Med J. 1999 May;76(5):281-3. UN-HABITAT; 2002. Abstract
Galactosaemia is a disorder of galactose metabolism in which raised levels of galactose and galactose-l-phosphate damage various organs. It is a very rare disease (incidence 1 in 60,000) and the diagnosis is often missed, leading to poor prognosis. A case of clinical galactosaemia that was diagnosed at the age of 11 months is reported. It is important to be aware of this condition as early treatment may prevent some of the complications.
DR. LUKHOBA CATHERINEW. "Lukhoba C.W. 2001. Taxonomic revision of the genera Ocimum L. and Plectranthus L.". In: Ph. D. Thesis, University of Nairobi.; 2001. Abstract

Ocimum L. and Plectranthus L'Hér. are cosmopolitan genera in the tribe Nepeteoideae in the family Labiatae Juss. The accumulation of essential oils in their flower and foliage has contributed to their prominence and popularity in traditional and conventional medicine, in cosmetology and perfumery, in the food industry as preservatives and spices, and more recently in the manufacturing industry as ingredients for pesticides, plastics, paints, etc.

The taxonomic aspect of the group has lagged well behind the economic one. The latest world- wide account of the two genera was by Briquet (1895-7), more than 100 years ago. In both these taxa, the taxonomic delimitation has been inadequate, the major problem being the continuous nature of the variation of characters particularly the morphological ones, which results in difficulties in circumscription of species. To further complicate the situation, Ocimum species tend to hybridize readily and undergo polymorphism. Morphological characters have proved to be inadequate in delimitation of the genera. It is therefore imminent that other criteria be investigated to substitute or corroborate the morphological ones in the delimitation of these two genera.
The major aim of this project was therefore to find novel morphological characters or novel combinations of already known characters and the value of new criteria from phytochemical data and anatomy to augment the morphological data in the delimitation of Ocimum and Plectranthus. Field and herbarium collections were used in this study. Gas-liquid chromatography/mass spectrometry (GLC/MS) on the essential oils from field samples were conducted in the chemotaxonomic study while the surface anatomical characters of Plectranthus were analyzed using the scanning electron microscope (SEM). In the revision of Ocimum, new morphological characters have been identified that can differentiate between sections and even between species, for instance, in the dendrite-haired species of subsection Gratissima, O. cufodontii and O. jamesii have n-shaped while O. spicatum have bowl-shaped anthers. Morphological features separating O. basilicum and O. americanum were established. In Plectranthus, three new species namely, P. agnewii C. Lukhoba & A. Paton, P. xylopodus C. Lukhoba & A. Paton sp. nov. and P. kwalensis C. Lukhoba & J. Kokwaro as well as the varieties P. barbatus var. glabricalyx C. Lukhoba & J. Kokwaro and P. edulis var. longiflora C. Lukhoba & J. Kokwaro have been described. One name change, P. igniarius var. verdcourtii C. Lukhoba & J. Kokwaro formerly P. igniarius var. grandicalyx) has been made. The chemical analysis conducted on four Ocimum and eleven Plectranthus species revealed the presence of numerous essential oil constituents. Some compounds were species-specific, some genera-specific while others were common to both genera thus can be of taxonomic value. The species O. basilicum, O. kilimandscharicum and O. kenyense clustered together in the cluster analysis. These three species have traditionally been grouped together in the section Ocimum. O. gratissimum showed greater affinity to Plectranthus than to Ocimum. The Plectranthus species came out as one homogenous group with two subgroups. The anatomical analysis of Plectranthus showed the indumentum to have a large number of sessile glands (peltate, gland dots), some capitate glands and numerous multi-cellular eglandular hairs. The viscid species P. kamerunensis and P. agnewii had the highest number of capitate glands. The presence, structure and nature of the stomata and glands were of taxonomic importance. Seven species had amphistomatic stomata and another seven species had stomata on the stems. The stratification of the leaf and stem surfaces was also found to be taxonomically significant. Cluster analysis showed that members of subgenus Calceolanthus clustered together into one group. They were also distinct from subgenus Plectranthus. A key based on these anatomical characters was drawn up to identify species in Plectranthus. Ethnomedicinal data revealed that Ocimum and Plectranthus species are popularly used to cure or alleviate gastro-intestinal, febrile, respiratory and skin conditions. Four species namely, O. basilicum, O. kilimandscharicum, O. gratissimum and P. barbatus showed high potential for further pharmacological evaluation, and for incorporation into local health care systems. This data also revealed that the medicinal species in the two genera are greatly affected by the current degradation of the environment. Thus propagation of the potentially medicinal ones was recommended. It is recommended that future taxonomic revisions of the two genera should include chemotaxonomic and anatomical data as they have proved to be promising criteria. Members of the two genera that have substantial amounts of essential oils can be commercially utilized in industry. The promising medicinal Ocimum and Plectranthus species can be incorporated into the primary health care systems. It is hoped that the new criteria used in this study will be relevant for the on-going revision of the family Labiatae for the Flora of Tropical East Africa.

DR. LUKHOBA CATHERINEW. "Lukhoba C.W. and Midiwo, J.O. 2001. Kenyan aromatic plants with a potential for economic utilization. First National Workshop On Medicinal, Aromatic and Other Under-utilised Plant Species in Kenya, 29th October- 3rd November, 2001.". In: First National Workshop On Medicinal, Aromatic and Other Under-utilised Plant Species in Kenya, 29th October- 3rd November, 2001.; 2001.
OBIMBO DRLAMUKAPETER. "Lamuka P.O. 2001. The Potential Role of Lactoperoxidase systems in milk preservation for increased smallholder dairy production and marketing in Kenya. A study done for the smallholder Dairy Project (SDP), MOALD/KARI/ILRI/Collaborative Research programme,.". In: Eur J. Biochem. Heinrich Boll Foundation.; 2001. Abstract
Thymidine kinase is an enzyme involved in DNA precursor metabolism and DNA replication. The synthesis of this enzyme is highly regulated during the cell cycle and the activity of the enzyme is also regulated by feedback inhibition. Genes encoding thymidine kinase have been extremely useful as selectable markers for introducing DNA into a number of cells. In order to study cell cycle regulation of thymidine kinase, the gene which encodes this enzyme, as well as aspects of DNA replication in the ciliated protozoan Tetrahymena thermophila, we have purified thymidine kinase from Tetrahymena. Two forms of thymidine kinase with native molecular masses of 59 kDa and 80 kDa have been identified and purified 6800- and 4600-fold, respectively. The 59-kDa enzyme, a homodimer of 30-kDa subunits, has been purified to near homogeneity and polyclonal antibodies have been raised against the 30-kDa subunit. Serological studies indicate that the two enzymes are antigenically distinct. The antibody against the Tetrahymena protein cross-reacts with a polypeptide in Chinese hamster ovary (CHO) cell extracts of 26 kDa which corresponds to the reported size of Chinese hamster thymidine kinase protein.
A. DRSWAZURIMUHAMMED. ""Land Development Options for Coastal Islands of Mombasa and Lamu", paper presented at an International Seminar on Urban Land Management, February 25-26 2001, Nairobi.". In: Key issues for Developing Countries. 1992 Ed., Bhatnagar S.C., pp. 103-114. Tata-Mcgraw-Hill. African International Business and Management Conference, Nairobi, Kenya; 2001. Abstract
This article reveals that the concept of education as a process of growth is a difficult one. Philosophers are, therefore, justified in being weary when pondering over its meaning, both in theory and practice. By way of conclusion, the article appreciates the complexities inherent in the growth theory of education, summarizing its major strength and weaknesses. Then it cautions educational planners and practitioners to be weary when, and if, they translate the theory into practice, so that they utilize the strengths inherent in the theory whilst paying attention to the dangers of its inherent weaknesses.
OKOTH PROFOGENDOHASTINGW. ""Land Rights, Food Security and Poverty", paper for the conference on Women and Land Rights in Eastern Africa held in Kampla, Uganda, October 28-November 1.". In: Cent. Afri. J. Pharm.Sci. 5(3): 60-66. Cent. Afri. J. Pharm.Sci. 5(3): 60-66; 2001. Abstract
The identification of five novel compounds, pseudo-erythromycin A-6,9-hemiketal, 8,9-anhydro-pseudo-erythromycin A-6,9-hemiketal, 8,9-anhydro-pseudo-N-demethylerythromycin A-6,9-hemiketal, 5-O-beta-D-desosaminylerythronolide A and 15-nor-erythromycin C, in mother liquor concentrates of Streptomyces erythraeus is described. The pseudo-erythromycin derivatives are characterized by a 12-membered macrocyclic ring as a result of C13––C11 trans-lactonization. The five compounds have very little antimicrobial activity.
JOAB PROFBWAYOJOB. "Late seroconversion in HIV-resistant Nairobi prostitutes despite pre-existing HIV- specific CD8+ responses. Kaul R, Rowland-Jones SL, Kimani J, Dong T, Yang HB, Kiama P, Rostron T, Njagi E, Bwayo JJ, MacDonald KS, McMichael AJ, Plummer FA. J Clin Invest. .". In: J Clin Invest. 2001 Feb;107(3):341-9. Asian Economic and Social Society; 2001. Abstract
Background. The host immune response against mucosally-acquired pathogens may be influenced by the mucosal immune milieu during acquisition. Since Neisseria gonorrhoeae can impair dendritic cell and T cell immune function, we hypothesized that co-infection during HIV acquisition would impair subsequent systemic T-cell responses.   Methods. Monthly screening for sexually transmitted infections (STIs) was performed in high risk, HIV seronegative Kenyan female sex workers as part of an HIV prevention trial. Early HIV-specific CD8+ T cell responses and subsequent HIV viral load set point were assayed in participants acquiring HIV, and were correlated with the presence of prior genital infections during HIV acquisition.   Results. Thirty-five participants acquired HIV during follow up, and 16/35 (46%) had a classical STI at the time of acquisition. N. gonorrhoeae co-infection was present during HIV acquisition in 6/35 (17%), and was associated with an increased breadth and magnitude of systemic HIV-specific CD8+ T-cell responses, using both interferon- (IFNg) and MIP-1 beta (MIP1b) as an output. No other genital infections were associated with differences in HIV-specific CD8+ T cell response, and neither N. gonorrhoeae nor other genital infections were associated with differences in HIV plasma viral load at set point.   Conclusion. Unexpectedly, genital N. gonorrhoeae infection during heterosexual HIV acquisition was associated with substantially enhanced HIV-specific CD8+ T-cell responses, although not with differences in HIV viral load set point. This may have implications for the development of mucosal HIV vaccines and adjuvants.
WANGAI DRKIAMAPETER. "Late seroconversion in HIV-resistant Nairobi prostitutes despite pre-existing HIV-specific CD8+ responses. Kaul R, Rowland-Jones SL, Kimani J, Dong T, Yang HB, Kiama P, Rostron T, Njagi E, Bwayo JJ, MacDonald KS, McMichael AJ, Plummer FA.J Clin Invest. 20.". In: J Clin Invest. 2001 Feb;107(3):341-9. Academic Press Elsevier. Int.; 2001. Abstract
Resistance to HIV infection in a small group of Kenyan sex workers is associated with CD8+-lymphocyte responses to HIV cytotoxic T-lymphocyte (CTL) epitopes. Eleven prostitutes meeting criteria for HIV resistance seroconverted between 1996 and 1999. The occurrence and specificity of preexisting HIV-1 epitope-specific responses were examined using the IFN-gamma enzyme-linked immunospot assay, and any epitopes recognized were cloned and sequenced from the infecting viral isolate. Immunologic and behavioral variables were compared between late seroconverters and persistently uninfected sex worker controls. HIV-1 CTL epitope responses were present in four of six cases, 5-18 months before seroconversion, and their presence was confirmed by bulk CTL culture. A possible viral escape mutation was found in one of six epitopes. The key epidemiologic correlate of late seroconversion was a reduction in sex work over the preceding year. In persistently uninfected controls, a break from sex work was associated with a loss of HIV-specific CD8+ responses. Late seroconversion may occur in HIV-1-resistant sex workers despite preceding HIV-specific CD8+ responses. Seroconversion generally occurs in the absence of detectable CTL escape mutations and may relate to the waning of HIV-specific CD8+ responses due to reduced antigenic exposure.
O PROFNYINGUROPHILIP. ""Legislation and the Proliferation of Small Arms in Kenya".". In: Human Security, Vol. 1 no. 8 , pp 16-27.; 2001. Abstract
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ONJUA PROFOYIEKEJB, OTIENO DRODAWAFRANCISXAVIER. "A Life Saving Skills Manual in Reproductive Health.". In: June 2001(Draft edited and in press). EM Ngatia, LW Gathece, FG Macigo, TK Mulli, LN Mutara, EG Wagaiyu.; 2001. Abstract
OBJECTIVE: In sub-Saharan Africa, many family planning programmes do not encourage advance provision of oral contraceptives to clients who must wait until menses to initiate pill use. Since some resistance to advance provision of pills is due to provider fears that the practice may be harmful, we conducted a study in Kenya in 1997 to compare pill-taking outcomes between 20 "advance provision" clients and 280 "standard" clients. DESIGN: Prospective observational study. SETTING: Six family planning clinics in Central and Western Kenya. SUBJECTS: Women presenting as new clients at MOH family planning clinics. INTERVENTIONS: Researchers used prospective tracking to compare indicators of pill-taking success between non-menstruating clients given pills to carry home for later use and menstruating clients who began pill use immediately. MAIN OUTCOME MEASURES: Pill-taking outcomes such as side effects, compliance, knowledge, satisfaction, and a continuation proxy. RESULTS: Among clients returning for re-supply, those receiving advance provision of pills did no worse than, and often had superior outcomes to, their counterparts who started taking pills immediately after the clinic visit. CONCLUSIONS: Advance provision of pills, already practiced worldwide, is safe and feasible. Explicit mention should be made of advance provision of pills in national family planning guidance documents and training curricula in Kenya and throughout sub-Saharan Africa.
ONJUA PROFOYIEKEJB, OTIENO DRODAWAFRANCISXAVIER. "A Life Saving Skills Manual in Reproductive Health.". In: June 2001(Draft edited and in press). Elsevier; 2001. Abstract
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MWAGIRU PROFMAKUMI. "Linkages of Conflict in East Africa: An Overview'.". In: African Review of Foreign Policy, Vol.3, No.2. University of Nairobi; 2001. Abstract
FES Papers in Conflict Management, No. 2
A. PROFKARANIFLORIDA. ""Literacy and Education".". In: The OSSREA Kenya Chapter National Conference on Poverty, Literacy, Health and Environmental Issues in Kenya : Exploring the Alternative Strategies. 28 th to 30 th March 2001. Stem Hotel. Nakuru. Kenya. Journal of BiochemiPhysics; 2001. Abstract
   
A. PROFKARANIFLORIDA. ""Literacy and Education".". In: The OSSREA Kenya Chapter National Conference on Poverty, Literacy, Health and Environmental Issues in Kenya : Exploring the Alternative Strategies. 28 th to 30 th March 2001. Stem Hotel. Nakuru. Kenya. Journal of BiochemiPhysics; 2001. Abstract

 

 

. DRNYANGAYAJAMESA. "Local Development of a Production Process for Replacement Cylinder Head Journal of Agriculture Science and technology (JAST) Vol. 3 (2) 2001.". In: J Obst Gynecol East Cent. Afric. DR. MARK NELSON AWORI; PROF. PANKAJ G. JANI; 2001. Abstract
Twenty variceal banding sessions were performed in eight patients between February 1995 and September 1996. A total of 69 rings were used to band the varices and at each session between two to six rings were used. Two of the eight had active bleeding and both underwent variceal banding to successfully arrest their bleeding as inpatients. Sixteen other variceal banding sessions were performed on an outpatient basis to obliterate their varices. Four of the eight patients had had sclerotherapy before and varices were still present. No acute or long term complications were noted. In one patient, variceal banding could not be performed as he developed stridor upon placement of the overtube. All the patients had advanced varices (Grade III or IV) and extended for more than 15 cms in the oesophagus. Endoscopic variceal obliteration remains the treatment of choice for patients with portal hypertension with variceal bleeding. Variceal banding is associated with a superior outcome when compared with sclerotherapy; the variceal kill time is shorter, infective complications less, rebleeding occurs less commonly and transfusion requirements are lower.
JOAB PROFBWAYOJOB. "Lymphocyte subsets in human immunodeficiency virus type 1-infected and uninfected children in Nairobi. Embree J, Bwayo J, Nagelkerke N, Njenga S, Nyange P, Ndinya-Achola J, Pamba H, Plummer F.Pediatr Infect Dis J. 2001 Apr;20(4):397-403.". In: Pediatr Infect Dis J. 2001 Apr;20(4):397-403. Asian Economic and Social Society; 2001. Abstract
Background. The host immune response against mucosally-acquired pathogens may be influenced by the mucosal immune milieu during acquisition. Since Neisseria gonorrhoeae can impair dendritic cell and T cell immune function, we hypothesized that co-infection during HIV acquisition would impair subsequent systemic T-cell responses.   Methods. Monthly screening for sexually transmitted infections (STIs) was performed in high risk, HIV seronegative Kenyan female sex workers as part of an HIV prevention trial. Early HIV-specific CD8+ T cell responses and subsequent HIV viral load set point were assayed in participants acquiring HIV, and were correlated with the presence of prior genital infections during HIV acquisition.   Results. Thirty-five participants acquired HIV during follow up, and 16/35 (46%) had a classical STI at the time of acquisition. N. gonorrhoeae co-infection was present during HIV acquisition in 6/35 (17%), and was associated with an increased breadth and magnitude of systemic HIV-specific CD8+ T-cell responses, using both interferon- (IFNg) and MIP-1 beta (MIP1b) as an output. No other genital infections were associated with differences in HIV-specific CD8+ T cell response, and neither N. gonorrhoeae nor other genital infections were associated with differences in HIV plasma viral load at set point.   Conclusion. Unexpectedly, genital N. gonorrhoeae infection during heterosexual HIV acquisition was associated with substantially enhanced HIV-specific CD8+ T-cell responses, although not with differences in HIV viral load set point. This may have implications for the development of mucosal HIV vaccines and adjuvants.
Gichuki FN;, Mungai DN;, Gachene CKK;, Thomas DB. "Land and water management in Kenya: towards sustainable land use.".; 2000. Abstract

Preliminary findings on the effects of land use in the Masinga Dam catchment, Kenya, on the storage capacity of the reservoir are presented. Remote sensing and GIS techniques, supplemented with ground reports, were used to determine areas most susceptible to erosion. A representative catchment was then chosen for rainy season monitoring of soil loss, river suspended sediments and discharge response to rainfall. In addition, Gerlach-type traps were used to evaluate erosion rates under different crop covers and slope gradients. A sample of 200 households was interviewed about their perceptions of erosion problems on their farms. Preliminary results suggest that the major sediment-contributing areas are the densely populated and intensively cultivated foothills of the Aberdares, rather than the semi-arid lowlands directly bordering the reservoir. Poorly drained sealed and murram roads, together with footpaths, cattle tracks and gullies, act as extensions of the drainage network during storms, channelling sediment-laden runoff from bare areas around homesteads and schools directly into the river. Subsistence crops, particularly mono-cropped maize, appear to provide poor cover for a major part of the wet season.

Gichuki FN;, Mungai DN;, Gachene CKK;, Thomas DB. "Land and water management in Kenya: towards sustainable land use.".; 2000. Abstract

Preliminary findings on the effects of land use in the Masinga Dam catchment, Kenya, on the storage capacity of the reservoir are presented. Remote sensing and GIS techniques, supplemented with ground reports, were used to determine areas most susceptible to erosion. A representative catchment was then chosen for rainy season monitoring of soil loss, river suspended sediments and discharge response to rainfall. In addition, Gerlach-type traps were used to evaluate erosion rates under different crop covers and slope gradients. A sample of 200 households was interviewed about their perceptions of erosion problems on their farms. Preliminary results suggest that the major sediment-contributing areas are the densely populated and intensively cultivated foothills of the Aberdares, rather than the semi-arid lowlands directly bordering the reservoir. Poorly drained sealed and murram roads, together with footpaths, cattle tracks and gullies, act as extensions of the drainage network during storms, channelling sediment-laden runoff from bare areas around homesteads and schools directly into the river. Subsistence crops, particularly mono-cropped maize, appear to provide poor cover for a major part of the wet season.

Gachene CKK;, Palm CA;, Mureithi JG. "Legume cover crops for soil fertility improvement in the highlands of eastern Africa region. Report of an AHI workshop."; 2000. Abstract

This report reviews work on legume cover crops in eastern Africa and provides a summary of recommendations of the appropriate germplasm, management and posible niches for these plants in farming systems. It briefly identifies various reseasons for the lack of adoption of LCC in farming sysytems. The focus is primarily on herbaceous legume cover plants that attain maximum biomass in less than 12 months.

N. DRWACHEGEPATRICK. "Living to die, Dying to Live: African Christian Insights, Nairobi: Media Options, 2000 (343 pp.).". In: Published by the Polytechnic of Berlin, Berlin. Heinrich Boll Foundation.; 2000.the_abstract.pdf
DR. LUKHOBA CATHERINEW. "Lukhoba, C. & Paton, A.J., 2000. Two new species of Plectranthus L.". In: Kew Bulletin, 55 (4): 957-964.; 2000.
DR. LUKHOBA CATHERINEW. "Lukhoba, C., 2000. Medicinal plants: Their role and future. First Symposium on EastAfrica in Transition: Communities, Cultures and Change, 4th-7th July 2000, Nairobi.". In: First Symposium on EastAfrica in Transition: Communities, Cultures and Change, 4th-7th July 2000, Nairobi.; 2000.
PROF. NTIBA MICHENIJ. "The Lake Victoria: A New Beginning .". In: ISBN. 9970-713-01-0. ELOQUENT BOOKS NY, Strategic Book Group, Connecticut, USA. ISBN-978-1-60911-081-9.Pages1; 2000. Abstract
Normal 0 false false false MicrosoftInternetExplorer4 st1:*{behavior:url(#ieooui) } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} Macrophytes have been shown to perform important ecological roles in Lake Naivasha. Consequently, various studies regarding the impact of biotic factors on the macrophytes have been advanced but related studies on environmental parameters have lagged behind. In an attempt to address this gap, sampling on floating species and submergents was carried out in eight sampling sites in 2003 to investigate how they were influenced by a set of environmental factors. Soil texture (sandy sediments; P < 0.05, regression coefficient = - 0.749) and wind were the most important environmental parameters influencing the distribution and abundance of floating macrophytes. Combination of soil texture and lake-bed slope explained the most (86.3%) variation encountered in the submergents. Continuous translocation of the floating dominant water hyacinth to the western parts by wind has led to displacement of the submergents from those areas. In view of these findings, the maintenance and preservation of the steep Crescent Lake basin whose substratum is dominated by sand thus hosting most submergents remain important, if the whole functional purpose of the macrophytes is to be sustained.
TOM DONDICHO. "Land alienation, land tenure and tourism in Kajiado district of Kenya.". In: African Studies monograph to be considered for publication. East African Social Science Research Review 16 (2): 49-70; 2000. Abstract

ABSTRACT The literature and research on domestic violence against women have

received increased attention in the 1980's and 1990's, but research on wife beating/battering

is still sparse. This paper reports from a research project in Nairobi that focused on the legal

experiences of battered women and their perceptions of the violence. Findings reveal that the

problem of battering is rampant and most battered women do not seek legal intervention. It

was also found that a majority of the women remained in intimate relationships with their

batterers due to economic dependence on the batterers and lack of alternatives outside the

relationship.

Key Words: Domestic violence; Legal Experiences; Nairobi; Kenya.

ADHIAMBO MRSOSANJOL. "Lands on Campus, Report: African Design Perspectives as Discussed by PJ Aranador (Philippines).". In: Faculty of Architecture, Design and Development, facilitated by Product Design and Development Center, Nairobi. ISCTRC; 2000. Abstract

The Department of Design, University of Nairobi recently hosted internationally reknowed Filipino Design Consultant, PJ Aranador. This event was a milestone, in many ways, for design in Kenya in that we had a distinguished designer, with an equally distinguished audience, discussing an important economic aspect lof national development. PJ is a design consultant for all major Philippine Trade Fares and a product development consultant for his government. He has been interviewed by CNNs' Elsa Klench in "Style:. And, "PJ" products sell on the international market with the buy line - "Style made modern". These styles include casual wear, swim wear and youthful clothes. PJ also indulges in interior and industrial design. The lecture included slides, posters and transparencies and was attended by a record assembly of over 100 participants from the major tertiary institutions in Kenya that offer design courses such as Evelyn College of Design, Marion Institute College, The Kenya Polytechnic and the University of Nairobi itself". This is the first assembly of these various tertiary institutions in pursuit of one goal - to listen and share in the experience of a fellow designer. PJ, on his part, gave a broad overview of the design profession, touching on its importance as an economic activity and its difference and similarities with Fine art. Design engages art and other factors in conception, but is driven by market forces because design is primarily, a marketing function. Design must concern itself with production unlike Art, which is not driven by reproduction. As a function of marketing, designers need to be sensitive to consumers of their products.

WAIRIMU PROFKIBERALUCY. ""Launching of Literacy Materials Workshop".". In: UNE SCO/UNESCO/UNIT WIN CHAIR Workshop , 26 th - 28 th July,2000. AIDS 24(6):891-7; 2000. Abstract
Department of Infectious Disease Epidemiology, Imperial College School of Medicine, London, UK. Previous attempts to determine the interactions between filariasis transmission intensity, infection and chronic disease have been limited by a lack of a theoretical framework that allows the explicit examination of mechanisms that may link these variables at the community level. Here, we show how deterministic mathematical models, in conjunction with analyses of standardized field data from communities with varying parasite transmission intensities, can provide a particularly powerful framework for investigating this topic. These models were based on adult worm population dynamics, worm initiated chronic disease and two major forms of acquired immunity (larval- versus adult-worm generated) explicitly linked to community transmission intensity as measured by the Annual Transmission Potential (ATP). They were then fitted to data from low, moderate and moderately high transmission communities from East Africa to determine the mechanistic relationships between transmission, infection and observed filarial morbidity. The results indicate a profound effect of transmission intensity on patent infection and chronic disease, and on the generation and impact of immunity on these variables. For infection, the analysis indicates that in areas of higher parasite transmission, community-specific microfilarial rates may increase proportionately with transmission intensity until moderated by the generation of herd immunity. This supports recent suggestions that acquired immunity in filariasis is transmission driven and may be significant only in areas of high transmission. In East Africa, this transmission threshold is likely to be higher than an ATP of at least 100. A new finding from the analysis of the disease data is that per capita worm pathogenicity could increase with transmission intensity such that the prevalences of both hydrocele and lymphoedema, even without immunopathological involvement, may increase disproportionately with transmission intensity. For lymphoedema, this rise may be further accelerated with the onset of immunopathology. An intriguing finding is that there may be at least two types of immunity operating in filariasis: one implicated in anti-infection immunity and generated by past experience of adult worms, the other involved in immune-mediated pathology and based on cumulative experience of infective larvae. If confirmed, these findings have important implications for the new global initiative to achieve control of this disease.
O. PROFNDINYA-ACHOLAJ. "Lavreys L, Thompson ML, Martin HL Jr, Mandaliya K, Ndinya-Achola JO, Bwayo JJ, Kreiss J.Primary human immunodeficiency virus type 1 infection: clinical manifestations among women in Mombasa, Kenya.Clin Infect Dis. 2000 Mar;30(3):486-90.". In: Clin Infect Dis. 2000 Mar;30(3):486-90. IBIMA Publishing; 2000. Abstract
The occurrence of clinical manifestations associated with primary human immunodeficiency virus type 1 (HIV-1) infection was evaluated in a prospective cohort study of female sex workers in Mombasa, Kenya. Among 103 women who seroconverted to HIV-1, fever, vomiting, diarrhea, headache, arthralgia, myalgia, skin rash, swollen lymph nodes, extrainguinal lymphadenopathy, inguinal lymphadenopathy, and vaginal candidiasis were noted significantly more frequently at visits in which seroconversion first became evident. Eighty-one percent of seroconverting women had >/=1 of these 11 symptoms or signs. Among 44% of the women, the acute illness was severe enough to prevent them from working. Having >/=2 of 6 selected symptoms and signs yielded a sensitivity of 51%, specificity of 83%, positive likelihood ratio of 3.2, and negative likelihood ratio of 0.5 for acute HIV-1 infection. The recognition of primary HIV-1-infection illness in high-risk populations and subsequent risk-reduction counseling could potentially reduce secondary HIV-1 transmission during this highly infectious period.
KANINI MRMBWESAJOYCE. "Learning for economic development : a case study of West African women and their potential replication: Seminar for the working group in on-formal education, University of Nairobi.". In: Seminar for the working group in on-formal education, University of Nairobi. au-ibar; 2000. Abstract
A cross sectional study of 115 patients admitted at the Department of Orthopedics, Kenyatta National Hospital, Nairobi, Kenya was carried out to determine the prevalence and antibiotic susceptibility of Staphylococcus aureus isolated from infected wounds. The prevalence of Staphylococcus aureus was 33.0 %. The drugs tested and their corresponding sensitivity was amoxycillin (13.2 %), co-amoxyclav (39.5 %), oxacillin (55.3 %), erythromycin (44.7 %), gentamicin (60.5 %), ciprofloxacin (62.2 %), minocycline (86.8 %), cefuroxime (57.9 %), and clidamycin (84.2 %). These results show the sensitivity profile of Staphylococcus aureus and can be used to choose suitable drugs in the management of wounds for hospitalized patients.
KANINI MRMBWESAJOYCE. "Learning for economic development : a case study of West African women and their potential replication: Seminar for the working group in on-formal education, University of Nairobi.". In: Seminar for the working group in on-formal education, University of Nairobi. au-ibar; 2000. Abstract
A cross sectional study of 115 patients admitted at the Department of Orthopedics, Kenyatta National Hospital, Nairobi, Kenya was carried out to determine the prevalence and antibiotic susceptibility of Staphylococcus aureus isolated from infected wounds. The prevalence of Staphylococcus aureus was 33.0 %. The drugs tested and their corresponding sensitivity was amoxycillin (13.2 %), co-amoxyclav (39.5 %), oxacillin (55.3 %), erythromycin (44.7 %), gentamicin (60.5 %), ciprofloxacin (62.2 %), minocycline (86.8 %), cefuroxime (57.9 %), and clidamycin (84.2 %). These results show the sensitivity profile of Staphylococcus aureus and can be used to choose suitable drugs in the management of wounds for hospitalized patients.
MWAGIRU PROFMAKUMI. "The Legal Framework for CEWARN.". In: Lawrenceville, NJ.: Red Sea Press, 2002; also in IGAD, Protocol on the Establishment of a Conflict Early Warning and Response Mechanism for IGAD Member States (Djibouti: IGAD, 2002). University of Nairobi; 2000. Abstract

This article explains the rationale of the various provisions of the Protocol establishing CEWARN (IGAD's conflict early warning and response mechanism).  It outlines the various levels of administration of the conflict early warning mechanism and analyses their legal and practical rationale.

ODUOR PROFOGENDOSTEPHEN. "Long term valve-related morbidity following open-heart surgery at the Kenyatta National Hospital.". In: East Afr Med J. 2000 Apr;77(4):199-202. The East and Central African Journal of Surgery.; 2000. Abstract
OBJECTIVE: To determine the incidence of valve morbidity associated with post-operative valve patients at the Kenyatta National Hospital, Nairobi. DESIGN: A combined retrospective and prospective study. Restrospective period from 1973 to 31st July 1977 and prospective period from there on to 31st July 1998. SETTING: Cardiothoracic outpatient clinic at Kenyatta National Hospital, Nairobi. PATIENTS: All valve replacement patients attending the cardiothoracic outpatient clinic on follow up following discharge from the ward. OUTCOME MEASURES: Morbidity was assessed by incidence of: stroke, thromboembolism, valve thrombosis, bleeding episodes, valve endocarditis and re-operation for valve failure. RESULTS: For all valve surgery combined the overall follow up rate equalled 476.3 patient years. The linearised occurrence rate for thromboembolism for all valves was 1.04% per patient year. For the mechanical valves this incidence was 1.32% per patient year. The stroke free rate at one year and five years was 97.7% and 95.9% respectively. The linearised incidence rate for stroke was 0.84% per patient year for all valves. The incidence of bleeding episodes, excluding menorrhagia, for mechanical valves was 0.79% per patient year. Three episodes of valve thrombosis were observed in this study group, all occurring with mechanical valves. For mechanical valves the incidence equalled 0.79% per patient year. The incidence of prosthetic valve endocarditis equalled 0.42% per patient year for all valves combined, or 0.53% per patient year for mechanical valves. Three patients in the series had redo surgery due to valve failure (0.63%). The commutative occurrence of valve related morbidity for the study population for all valves analysed was 2.73% per patient year. CONCLUSION: The incidence of the various valve morbidity at the Kenyatta National Hospital are below the internationally quoted figures in the literature for other centres. The high incidence of drop out to clinic follow up is likely to be the main reason for this with a lot of morbidity occurring outside the hospital environment and therefore not documented. The exact estimation of this incidence is difficult to assess. To help ascertain this occurrence an accurate patient database with accurate (real time) contacts needs to be put into place.
AMOLO DROGADAPENINA. "Land and Property ownership for Women in Kenya, presented at UN Women's Day Panel. Discussion, UN New York, March 4th.". In: Paper Submitted for review, Journal of Civil Engineering Research and Practice. Heinrich Boll Foundation.; 1999. Abstract
Towers are typical structures that can be found in many urban and rural landscapes the world over. From their basic design, they are usually exposed to severe environmental loads. It is therefore prudent to carry out periodic maintenance that includes checking that they are correctly aligned. This paper describes a method that was used for the re-alignment of a guyed tower in Limuru, Kenya. Angular and distance observations, made from two observation points detected a vertical misalignment that was larger than the acceptable tolerance of l/400. An iterative re-alignment procedure was then applied, resulting in an acceptable final misalignment of 1 / 520.
OKOTH PROFOGENDOHASTINGW. ""Land policy development in East Africa: a survey of recent trendes"; paper for DFID workshop on Land Rights and Sub-Saharan Africa Sunningdale, England, February 16-19.". In: Cent. Afri. J. Pharm.Sci. 5(3): 60-66. Cent. Afri. J. Pharm.Sci. 5(3): 60-66; 1999. Abstract
The identification of five novel compounds, pseudo-erythromycin A-6,9-hemiketal, 8,9-anhydro-pseudo-erythromycin A-6,9-hemiketal, 8,9-anhydro-pseudo-N-demethylerythromycin A-6,9-hemiketal, 5-O-beta-D-desosaminylerythronolide A and 15-nor-erythromycin C, in mother liquor concentrates of Streptomyces erythraeus is described. The pseudo-erythromycin derivatives are characterized by a 12-membered macrocyclic ring as a result of C13––C11 trans-lactonization. The five compounds have very little antimicrobial activity.
JAMES PROFODEK. "Land Use Planning and Management (ACTS).". In: Paper presented at the WIPO High Level Forum on IP Policy and Strategy, Tokyo . Prof. James Otieno-Odek; 1999. Abstract
J. O. Midiwo, A. Yenesew, B. F. Juma, S. Dereses, J. A. Ayoo, A. Aluoch and S. Guchu There are several described medicinal plants in Kenya from a flora of approximately 10,000 members. Strong cross-medical information from the 42 ethnic groups points to the high potential of some of these species. The Myrsinaceae are well established ethno-anthelmintics and anti-bacterials. They are harbingers of long alkyl side chain benzoquinones which clearly have a protective function from their histochemical disposition. The main benzoquinone in the sub-family Myrsinodae is embelin while for the Maesodae it is maesaquinone together with its 5-acetyl derivative; the distribution of these benzoquinones by their alkyl side chain length or the presence/absence of a 6-methyl group is in accord with morphological sub-family de-limitation. The benzoquinones showed anti-feedant, anti-microbial, phytotoxic, acaricidal, insecticidal and nematicidal activity. Many other benzoquinones of medium and minor concentration were also isolated and characterised. Some plants belonging to the Polygonaceae which are widely used as ethno-anthelmintics have been studied. The common anthelmintic anthraquinones were obtained from all five Rumex species while the naphthalenic acetogenin derivative, nepodin was more selectively distributed. The leaf of Polygonum senegalense is up to 17% surface exudate; about thirteen non polar flavonoid derivatives (chalcones, dihydrochalcones, flavanones and a flavone) have been isolated from it. From the internal aerial tissues of this plant, the major flavonoids were common flavonoids, quercetin, kaempferol, luteolin and their glycosides. The only unique compound isolated from this plant was 2prime-glucosyl-6prime-hydroxy-4prime-methoxydihydrochalcone whose aglycone, uvangolatin is part of the exudate mixture. Other leaf exudate plants studied include the stomach-ache medicine, Psiadia punctulata (Compositae) from which novel methylated flavonoids, kaurene and trachyloban diterpenes have been found
OMOLO PROFWANGOEMMANUEL. "Langat D.K., Johnson P.M., Rote N.S., Mwenda J.M., Owiti G.O. Wango E.O. and Mwenda J.M. (1999). Immunohistochemical characterisation of retroviral-related antigens expressed in normal baboon placental villous tissue. J. Medical. Primatol., 27, 278-286.". In: 25th Annual Conference, 23rd . EM Ngatia, LW Gathece, FG Macigo, TK Mulli, LN Mutara, EG Wagaiyu.; 1999. Abstract

SUMMARY LIII)' lIIorpllOlogiClI changcs ill the goat ,csris after:. sillgle illlraperilOlieal injec,ioll of ethalle ,lillie' I.:lIIeslll"llOnarc (EI )S) werc investigatcd mint; (1Orh liglH alld deCll'On microscopy. The (olllpolind was ;almillistered at two dose Icvels: 75 mgll

OMOLO PROFWANGOEMMANUEL. "Langat D.K., Johnson P.M., Rote N.S., Wango E.O., Owiti G.O.,Isahakia M.A., and Mwenda J.M., (1999). Characterisation of antigens expressed in normal baboon trophoblast and cross reactive with HIV/SIV antibodies. J. Reprod. Immunol.42, 41-58.". In: 25th Annual Conference, 23rd . EM Ngatia, LW Gathece, FG Macigo, TK Mulli, LN Mutara, EG Wagaiyu.; 1999. Abstract

SUMMARY LIII)' lIIorpllOlogiClI changcs ill the goat ,csris after:. sillgle illlraperilOlieal injec,ioll of ethalle ,lillie' I.:lIIeslll"llOnarc (EI )S) werc investigatcd mint; (1Orh liglH alld deCll'On microscopy. The (olllpolind was ;almillistered at two dose Icvels: 75 mgll

O. PROFNDINYA-ACHOLAJ. "Lavreys L, Rakwar JP, Thompson ML, Jackson DJ, Mandaliya K, Chohan BH, Bwayo JJ, Ndinya-Achola JO, Kreiss JK.Effect of circumcision on incidence of human immunodeficiency virus type 1 and other sexually transmitted diseases: a prospective cohort study of .". In: J Infect Dis. 1999 Aug;180(2):330-6. IBIMA Publishing; 1999. Abstract
To determine the effect of circumcision status on acquisition of human immunodeficiency virus (HIV) type 1 and other sexually transmitted diseases, a prospective cohort study of 746 HIV-1-seronegative trucking company employees was conducted in Mombasa, Kenya. During the course of follow-up, 43 men acquired HIV-1 antibodies, yielding an annual incidence of 3.0%. The annual incidences of genital ulcers and urethritis were 4.2% and 15.5%, respectively. In multivariate analysis, after controlling for demographic and behavioral variables, uncircumcised status was an independent risk factor for HIV-1 infection (hazard rate ratio [HRR=4.0; 95% confidence interval [CI], 1.9-8.3) and genital ulcer disease (HRR=2.5; 95% CI, 1.1-5.3). Circumcision status had no effect on the acquisition of urethral infections and genital warts. In this prospective cohort of trucking company employees, uncircumcised status was associated with increased risk of HIV-1 infection and genital ulcer disease, and these effects remained after controlling for potential confounders.
K PROFGACHENECHARLESK. "Legume cover crops for soil fertility improvement in the East African Region. AHI (African Highland Initiative) Soils Working Group Report No. 1., AHI/TSBF, Nairobi, Kenya. 25 pp.". In: Biological Agricultural & Horticultural Journal, Vol 19(1), 49-62. F.N. kamau, G. N Thothi and I.O Kibwage; 1999. Abstract
A model for the establishment of a four-dimensional regional geodetic reference datum is presented. Starting from the three-dimensional integrated geodetic network model, formulations for the establishment of a four-dimensional regional datum are developed. Astronomic latitudes, astronomic longitudes, gravity values, gravity potential differences, gravity differences, and GPS-vectors are considered as observables. The estimated parameters defining the datura are point coordinates, deflections of the vertical and geoidai undulations, and velocities and accelerations on the positional coordinates. The network datum is considered observed over several epochs with parameters estimated from previous epochs being introduced into later epochs as stochastic prior information parameters.
WILLIAM PROFMUNYUAKIMANI. "Lewa, A.K., N. Maingi, W.K. Munyua, and T.A. Ngatia (1999). Seasonal population dynamics of gastrointestinal helminths in donkeys in Kiambu district of Kenya. Bull. Anim. Hlth. Prod. Afr. 47: 19-20.". In: Paper Presented in The 5th International Operations Research of Eastern Africa Conference, White Sands Hotel, Dar es Salaam, Tanzania, 16th . EM Ngatia, LW Gathece, FG Macigo, TK Mulli, LN Mutara, EG Wagaiyu.; 1999. Abstract
Normal 0 false false false MicrosoftInternetExplorer4 st1:*{behavior:url(#ieooui) } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} The research sought to find out the extent to which mobile phone users were aware about safe disposal of mobile phones. In addition the research went ahead to establish the avenues available to mobile phone manufacturers and users in order to enhance safe mobile disposal through a survey.  The research revealed that there was the need for the mobile manufacturers to manufacture handsets from recyclable materials. The manufacturers should also avail information on handset disposal at the point of sale and do a follow-up using the available media. The mobile services providers can also play an important role on mobile phone disposal by availing the information on the face of the scratch cards. In addition they can notify the subscribers on the available disposal channels through text messages. The government through the designated agencies such as the Communications Commission of Kenya (CCK) and National Environmental Management Authority (NEMA) needs to be more assertive in mobile phone disposal measures. Key words: Recycle, Disposal; Mobile Phone; handsets; Environment; Design; Kenya
KIIRU PROFMUCHUGUDH. "Literature at the Touch of a Key The People (Millennium Special), 31December." Philosophical Issues Invoked by Shona People; 1999. Abstract

O PROFNYAMBOKISAAC. "The lithospheric structure of the Kenya Rift as revealed by wide-angle seismic measurements.". In: In: Mac Caill, C. and Ryan, P.D. (eds). Continental Tectonics. Geological Society, London, Special Publications. 164, 254-269. Wiley Interscience; 1999. Abstract
Vertex epidural haematomas (VEDH) are rare and difficulties are encountered in diagnosis and management. This is a case report of a patient with a vertex epidural haematoma who presented with signs of severe head injury with upper limb decerebrate posture. We discuss the challenges of radiological investigation and neurosurgical management of VEDH.
M PROFNGECUWILSON. "Lithostratigraphic and facies distribution of Pleistocene sediments in southern Kenya Rift Valley at Munyu wa Gicheru Formation.". In: Journal of African Earth Sciences, Volume 29/2. Pp. 411-421. Asian Journal of Plant Sciences; 1999. Abstract
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OMONDI MRMISANGOQUIRENEBERNARD. "Locally Made Wind pumping System. A technical Report, 1987 (Revised 1992, 1997, 1999).". In: Far East J. of Theo. Stat. 18 (2), pp. 161 . Far East Journal of Theoretical Statistics; 1999. Abstract
v:* {behavior:url(#default#VML);} o:* {behavior:url(#default#VML);} w:* {behavior:url(#default#VML);} .shape {behavior:url(#default#VML);} 12.00 Normal 0 false false false EN-GB X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman","serif";} Common nearly best linear estimates of location and scale parameters of normal and logistic distributions, which are based on complete samples, are considered. Here the population from which the samples are drawn is either normal or logistic population or a fusion of both distributions and the estimates are computed when it is not yet known which of the two populations (between the normal and logistic) is true. The problem discussed in this paper involves two possible population types in a given sample. Samples of sizes  and  are used to validate these estimates and a comparison of their variances is made with those of the best linear unbiased estimators (BLUEs) for normal and logistic distributions.
K DRMUSAMBAYICHRISANTHUSIKALIKHA. "Long term policy perspecives for Kenya:Joint IPAR/AERC Seminar report.". In: Joint IPAR / AERC Seminar Report 1999 with P. Kimuyu. uon press; 1999. Abstract
{ The Blantyre coma scale (BCS) is used to assess children with severe falciparum malaria, particularly as a criterion for cerebral malaria, but it has not been formally validated. We compared the BCS to the Adelaide coma scale (ACS), for Kenyan children with severe malaria. We examined the inter-observer agreement between 3 observers in the assessment of coma scales on 17 children by measuring the proportion of agreement (PA), disagreement rate (DR) and fixed sample size kappa (kappa n). We assessed the sensitivity and specificity of the scales in detecting events (seizures and hypoglycaemia) in 240 children during admission and the usefulness of the scales in predicting outcome. There was considerable disagreement between observers in the assessment of both scales (BCS: PA = 0.55
Dorothy McCormick. "Linkages Between Small and Large Firms In the Kenyan Food Processing and Tourism Industries.". In: Linkages Between Small and Large Firms In the Kenyan Food Processing and Tourism Industries. Hague, Netherlands.: Cambridge: Cambridge University Press.; 1998. Abstract

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Magoha GAO. "Local infiltration and spermatic cord block for inguinal, scrotal and testicular surgery. .". In: East African Medical Journal, 75: 575-577, 1998. EAMJ; 1998. Abstract

This was a prospective study involving 372 male patients. Surgical procedures including simple inguinal hernia repair, inguinal lymph node biopsy, hydrocelectomy, testicular biopsy, testicular fixation, orchidectomy and scrotal exploration were performed under local anaesthesia using various quantities of 0.5% xylocaine with adrenaline depending on the procedure, in the form of spermatic cord block and local infiltration nerve blocks. No premedication was given to any patient and only five patients (1.34%) were given intraoperative sedation due to anxiety. No complication directly attributed to the anaesthetic agent used or the technique of spermatic cord and nerve blocks were reported during the study. Three hundred and sixty patients (96.77%) were operated on as outpatients and were happy and satisfied to return home on the same day. This experience confirms that spermatic cord block accompanied by local infiltration with 0.5% xylocaine with adrenaline is simple, safe and effective technique that should be used more widely in outpatient urological and general surgical settings in this locality. It provides excellent intra-scrotal and inguinal anaesthesia. Furthermore, the technique is cost effective, and personnel effective since no anaesthetist is required for the procedure which is usually carried out by the surgeon. This would enable many more people to afford the surgical procedures.

IKIARA MRGERRISHONK. "L'economie Kenyane Face a l'ajustement structural (1978-1995).". In: Frncois Grignon et Gerard Pruntier (eds). Asian Economic and Social Society; 1998. Abstract
Department of Paediatrics, College of Health Sciences, University of Nairobi, Kenya. Verbal autopsy was used to determine causes of death in 239 children under the age of 5 years. The diagnosis derived from verbal autopsy was corroborated with hospital diagnosis in 39 cases. There was concurrence of diagnosis in 72% of the cases. Using the diagnosis of bronchopneumonia to validate the method, verbal autopsy was found to have a sensitivity of 71%, specificity of 92%, a positive predictive value of 85%. Reliability index of agreement was 0.654. Recall period up to 29 months after death was found to be reliable. PMID: 2282890 [PubMed - indexed for MEDLINE]
K. DRKANYINGAHENRY. "The Land Question in Kenya: Struggles, Accumulation and Changing Politics. Unpublished PhD Dissertation, International Development Studies, Roskilde University, Denmark, 1998.". In: Citizenship and Rights: The Failures of Post-colonial State,Globalisation and Citizenship, Special issue of Africa Development Vol.(XXVIII) No. 1&2. Korean Society of Crop Science and Springer; 1998.
OMOLO PROFWANGOEMMANUEL. "Langat D.K., Johnson P.M., Rote N.S., Owiti G.O., Wango E.O. and Mwenda J.S. (1998). Characterisation of retroviral-related antigens expressed in normal baboon placental and other tissues. African J. Health Sci. 5,139-146.". In: Proceedings of the First Meeting of Federation of African Societies of Biochemistry and Molecular Biology (FASBMB), pp199-204. EM Ngatia, LW Gathece, FG Macigo, TK Mulli, LN Mutara, EG Wagaiyu.; 1998. Abstract

SUMMARY LIII)' lIIorpllOlogiClI changcs ill the goat ,csris after:. sillgle illlraperilOlieal injec,ioll of ethalle ,lillie' I.:lIIeslll"llOnarc (EI )S) werc investigatcd mint; (1Orh liglH alld deCll'On microscopy. The (olllpolind was ;almillistered at two dose Icvels: 75 mgll

JANET MSAYUGIROSE. "Law Reform Initiatives in Kenya: The Environmental Management and Coordination bill 1995/1998. South African Journal of Environmental Law and Policy.". In: Paris 2011 World Cup in Paris, France. The Icfai University Journal of Architecture, Vol. II No.1, February 2010; 1998. Abstract
In contrast with mammalian cells, little is known about the control of Ca2+ entry into primitive protozoans. Here we report that Ca2+ influx in pathogenic Trypanosoma brucei can be regulated by phospholipase A2 (PLA2) and the subsequent release of arachidonic acid (AA). Several PLA2 inhibitors blocked Ca2+ entry; 3-(4-octadecyl)-benzoylacrylic acid (OBAA; IC50 0.4+/-0.1 microM) was the most potent. We identified in live trypanosomes PLA2 activity that was sensitive to OBAA and could be stimulated by Ca2+, suggesting the presence of positive feedback control. The cell-associated PLA2 activity was able to release [14C]AA from labelled phospholipid substrates. Exogenous AA (5-50 microM) also initiated Ca2+ entry in a manner that was inhibited by the Ca2+ antagonist La3+ (100 microM). Ca2+ entry did not depend on AA metabolism or protein kinase activation. The cell response was specific for AA, and fatty acids with greater saturation than tetraeicosanoic acid (AA) or with chain lengths less than C20 exhibited greatly diminished ability to initiate Ca2+ influx. Myristate and palmitate inhibited PLA2 activity and also inhibited Ca2+ influx. Overall, these results demonstrate that Ca2+ entry into T. brucei can result from phospholipid hydrolysis and the release of eicosanoic acids.
DOROTHY MRSOMOLLO. "Legal, ethical and Gender implications of implementation of programmes on the Reduction of mother to child transmission of HIV/AIDS.". In: J Infect Dis. 1992 Aug;166(2):359-64. Earthscan, London. 978-1-84407-469-3 (*); 1998. Abstract

Division of Bacterial and Mycotic Diseases, Centers for Disease Control, Atlanta, GA 30333. An epidemic of meningococcal disease occurred in Nairobi, Kenya, during 1989, outside the "meningitis belt" of sub-Saharan Africa. About 3800 cases occurred between April and November (250/100,000 population). The case-fatality rate was 9.4% among hospitalized patients. Areas that included Nairobi's largest slums had particularly high attack rates. The epidemic displayed an unusual age distribution, with high attack rates among those 20-29 years old. A vaccination campaign was conducted. By early January, the weekly case count had fallen to 25 from a high of 272 (in September). A case-control study estimated the vaccine efficacy to be 87% (95% confidence interval, 67%-95%). A model estimated that the vaccination campaign reduced the number of cases by at least 20%. Multilocus enzyme electrophoretic typing demonstrated that the strain responsible for this large epidemic is closely related to strains that caused other recent epidemics, documenting further spread of what may be a particularly virulent clonal complex of group A Neisseria meningitidis.

OKOTH PROFOGENDOHASTINGW. ""Legislating land rights for the poor. A preliminary assessment of Uganda's Land Act 1998, paper for the Uganda Land Alliance Strategic Planning Workshop Mukono 6-8, September.". In: Cent. Afri. J. Pharm.Sci. 5(3): 60-66. Cent. Afri. J. Pharm.Sci. 5(3): 60-66; 1998. Abstract
The identification of five novel compounds, pseudo-erythromycin A-6,9-hemiketal, 8,9-anhydro-pseudo-erythromycin A-6,9-hemiketal, 8,9-anhydro-pseudo-N-demethylerythromycin A-6,9-hemiketal, 5-O-beta-D-desosaminylerythronolide A and 15-nor-erythromycin C, in mother liquor concentrates of Streptomyces erythraeus is described. The pseudo-erythromycin derivatives are characterized by a 12-membered macrocyclic ring as a result of C13––C11 trans-lactonization. The five compounds have very little antimicrobial activity.
ROSEMARY DRATIENO. ""Lending Policies and the Use of Credit Funds among Small Scale Farmers in Kenya". In: Savings and Development, Vol. 22, number 2, 1998.". In: Towards an Understanding of the Business Systems in Kenya:the concept and research issues in the metal products sub-sector". IDS Working Paper Number 534,. Journal of School of Continuous and Distance Education ; 1998.
WAKONYU DRKANJAL, ELIAS PROFMAITHOT. "Levels of organochlorine Pesticide residues in milk of Urban Mothers in Kenya.". In: journal. de Gruyter; 1998.

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