Rapid Decline in Risk of HIV-l Acquisition After Enrollment in a Vaccine Preparedness Cohort of Kenyan Prostitutes: Implications for the Design of HIV -1 Vaccine Efficacy Trials

Citation:
Baeten J, Richardson B, Martin H, Nyange P, Lavreys L, Ngugi EN, Bwayo JJ, Kreiss J, Mandaliya K. "Rapid Decline in Risk of HIV-l Acquisition After Enrollment in a Vaccine Preparedness Cohort of Kenyan Prostitutes: Implications for the Design of HIV -1 Vaccine Efficacy Trials.". 2002.

Abstract:

In designing HIY-l vaccine efficacy trials, it will be important to accounrfor changes in HIY -1 incidence, especially changes over time and while participating in riskreduction programs. Methods: Data from an open cohort of female prostitutes in Mombasa, Kenya were analyzed. Individuals were censored after 3 years of follow-up or at HIY -J seroconversion. Models of HIY -J and sexually transmitted disease incidence and sexual risk behaviors over time were constructed using generalized estimating equations. Annual HIV -1 incidence for the entire cohort was calculated. Results: The risk of HIY -J infection declined I O-fold during 3 years of follow-up (from 17.4 to 1.7 cases per 100 person-years for the first and last six months of follow-up, respectively, p

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