Predictors of early mortality in a cohort of human immunodeficiency virus type 1-infected african children. Pediatr Infect Dis J . 2004 Jun; 23 ( 6 ): 536-43 . PMID: 15194835 [PubMed - indexed for MEDLINE] Obimbo EM, Mbori-Ngacha DA, Ochieng JO, Richardso

Citation:
MBORI- PROFNGACHADOROTHYA, ELIZABETH DROBIMBO. "Predictors of early mortality in a cohort of human immunodeficiency virus type 1-infected african children. Pediatr Infect Dis J . 2004 Jun; 23 ( 6 ): 536-43 . PMID: 15194835 [PubMed - indexed for MEDLINE] Obimbo EM, Mbori-Ngacha DA, Ochieng JO, Richardso.". In: Pediatr Infect Dis J . 2004 Jun; 23 ( 6 ): 536-43 . Kisipan, M.L.; 2004.

Abstract:

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Department of Pediatrics, University of Nairobi, Nairobi, Kenya.
BACKGROUND: Pediatric human immunodeficiency virus type 1 (HIV-1) infection follows a bimodal clinical course with rapid progression in 10-45% of children before the age of 2 years and slower progression in the remainder. A prospective observational study was undertaken to determine predictors of mortality in HIV-1-infected African infants during the first 2 years of life. METHODS: Infants in a perinatal cohort identified to be HIV-1-infected by DNA PCR were followed monthly to 1 year, then quarterly to 2 years or death. RESULTS: Among 62 HIV-1-infected infants, infection occurred by the age of 1 month in 56 (90%) infants, and 32 (52%) died at median age of 6.2 months. All infant deaths were caused by infectious diseases, most frequently pneumonia (75%) and diarrhea (41%). Univariate predictors of infant mortality included maternal CD4 count <200 cells/microl [hazard ratio (HR), 3.4; P = 0.008], maternal anemia (HR = 3.7; P = 0.005), delivery complications (HR = 2.7; P = 0.01), low birth weight (HR = 4.1; P = 0.001), weight, length and head circumference

Notes:

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