Publications

Found 153 results

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2022
Dimba EAO, Newa F, Macharia J, Nyanumba MD. "Determinants of acceptance of eHealth technology by Health Care Practitioners in Nairobi, Kenya." East African Medical Journal. 2022;99:4450-4460. Abstract
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2021
Maina SW, Dimba E, Oyugi JO, Mwangi JW. "Antimicrobial efficacy of Hibiscus Fuscus garcke aqueous and ethanol extracts on tooth root canal microorganisms." East African Medical Journal. 2021;98. Abstract
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Mutwiri KD, Dimba E, Nzioka BM. "Orofacial Infections in Kenya: A Retrospective Study." Annals of African Surgery. 2021;18:45-51. Abstract
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2020
"Motivations for a career in dentistry among dental students and dental interns in Kenya." International Journal of Dentistry. 2020;Jul 29(1017979).
Lukandu OM, Koskei LC, Dimba EO. "Motivations for a Career in Dentistry among Dental Students and Dental Interns in Kenya." International journal of dentistry. 2020;2020. Abstract
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2019
2017
S Q, A L, J G, K K, W W, EA D. "Design and Implementation of the Retinoblastoma Collaborative Laboratory." Ocular Oncology and Pathology. 2017.
Qaiser S, Limo A, Gichana J, Kimani K, Githanga J, Waweru W, Dimba EAO, Dimaras H. "Design and implementation of the retinoblastoma collaborative laboratory." Ocular Oncology and Pathology. 2017;3:73-82. Abstract
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2016
Dimba EAO, Yengopal V, Joshua E, Thavarajah R, Balasundaram S. "Access and management of HIV-related diseases in resource-constrained settings: a workshop report." Oral diseases. 2016;22:206-210. Abstract
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Thavarajah R, Joshua E, Balasundaram S, Dimba E, Yengopal V. "Access and management of HIV-related diseases in resource-constrained settings: a workshop report.". 2016. Abstract
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2015
Naidoo S, Dimba E, Yengopal V, Folayan MO, Akpata ES. "Strategies for Oral Health Research in Africa and the Middle Eastern Region." Adv. Dent. Res.. 2015;27(1):43-9. Abstractstrategies_for_oral_health_research_in_africa_and_the_middle_eastern_region_-_abstract.pdf

The highest burden of diseases worldwide is in low- and middle-income countries, but due to lack of capacity and inadequate infrastructure, research output from these countries is unable to address existing and emerging challenges in health care. Oral health research has particularly been hampered by low prioritization, resulting in insufficient development of this sector. There is an urgent need for research correlating oral health to upstream social and environmental determinants and promoting the common risk factor approach for prevention of noncommunicable diseases. Population-wide preventive measures for oral health care are more effective than purely curative approaches, especially for vulnerable groups who have limited access to information and appropriate health care. This article identifies priorities and proposes strategies for researchers, stakeholders, and policy makers for the initiation and sustenance of appropriate oral health care research. The proposed interventions are intended to promote collaboration, capacity building, and health advocacy. Local ownership in multinational research projects in low- and middle-income countries, complemented by skills transfer from high-income countries, is encouraged to ensure that regional health needs are addressed. Emphasis is placed on a shift toward translational research that has a direct impact on oral health care systems.

GB B, F B, JF O, FM M, E D. "Antibiotic Sensitivity Patterns of Aerobic Bacterial Agents in Post-Surgical Orofacial Infections." The annals of African Surgery. 2015.
D S, N J, P W, M D’lima, chindia ML, E D, A N. "Diagnostic challenges of oral and cutaneous Kaposi’s sarcoma in resource-limited settings." Journal of Oral Pathology and Medicine. 2015.
SW M, E D, Oyugi JO, JW M, ST K, TM D. "Elimination of Biofilms in root canal system - a literature review." African Journal of Oral Health Sciences. 2015.
LN K, van den LW S, E D, NHJ C, MAW M, FF S, van der AJAM V. "High level drug resistance in patients on chronic anti-retroviral treatment presenting with oropharyngeal candidiasis in Kenya." Oral Diseases. 2015.
WA O, A K, L K, E D. "Massive Cervico-Lingual Cystic Hygroma." The annals of African Surgery. 2015.
S N, E D, V Y, MO F, ES A. "Strategies for Oral Health Research in Africa and the Middle Eastern Region." Advances in Dental Research. 2015.
Barasa GB, Butt F, Onyango JF, Mutua FM, Dimba E. "Antibiotic sensitivity patterns of aerobic bacterial agents in post-surgical orofacial infections." Annals of African Surgery. 2015;12. Abstract
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Maina SW, Dimba E, Oyugi JO, Kabuitu STK. "Antimicrobial Efficacy ofAzadirachta indica (Neem) Twigs Aqueous and Ethanol Extracts on Tooth Root Canals Biofilms." Inter. J. Pharmco. Phytochem.. 2015;7. Abstract
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Speicher DJ, Wanzala P, D'Lima M, Njiru A, Chindia M, Dimba E, Johnson NW. "Diagnostic challenges of oral and cutaneous Kaposi's sarcoma in resource-constrained settings." Journal of Oral Pathology & Medicine. 2015;44:842-849. Abstract
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Johnson NW, Dimba E, Chindia M, Njiru A, D'Lima M, Wanzala P, Speicher DJ. "Diagnostic challenges of oral and cutaneous Kaposi's sarcoma in resource-constrained settings.". 2015. Abstract
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Maina SW, Dimba E, Oyugi JO, Mwangi JW, Kabuitu SK, Dienya TM. "Elimination of Biofilms in root canal system." J. Oral Health Sci.. 2015;3. Abstract
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Maina SW, Oyugi JO, Dienya TM, Mwangi JW, Dimba E, Kabuitu STK. "Elimination of biofilms in root canal system-A literature review.". 2015. Abstract
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Odhiambo WA, Karega A, Kalisa L, Dimba E. "Massive Cervico-Lingual Cystic Hygroma." Annals of African Surgery. 2015;12. Abstract
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Koyio LN, van der Sanden WJM, Mulder J, Dimba EO, Creugers NHJ, Merkx TMAW, Stelma FF, van der Ven Andre JAM. "Pseudomembranous Candidiasis Indicates High Level Drug Resistance among Patients on Antiretroviral Treatment in Nairobi East District, Kenya." Journal of HIV for Clinical and Scientific Research. 2015;2:040-044. Abstract
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Kirimi J, Guthua S, Dimba E, OMONDI B, KOTA D. "Stage IV oral malignant melanoma: a case report and literature review." International Journal of Oral and Maxillofacial Surgery. 2015;44:e91. Abstract
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Naidoo S, Dimba E, Yengopal V, Folayan MO, Akpata ES. "Strategies for oral health research in Africa and the middle eastern region." Advances in dental research. 2015;27:43-49. Abstract
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2014
KA W, A V, DO A, EAO D, A M, AK L, J G, chindia ML. "Burning mouth syndrome presenting with oral lichen planus – A case report." African Journal of Oral Health Sciences. 2014.
DO A, KA W, EAO D, chindia ML, JF O, AK L, JO G. "Nasopalatine duct cyst." African Journal of Oral Health Sciences. 2014.
F B, EAO D, K S. "Treatment of keratocystic odontogenic tumour by marsupialization." African Journal of Oral Health Sciences. 2014.
Koyio LN, van der Sanden WJM, Dimba EO, Mulder J, van der Ven AJAM, Merkx MAW, Frencken JE. "Knowledge of Nairobi East District Community Health Workers concerning HIV-related orofacial lesions and other common oral lesions." BMC public health. 2014;14:1-8. Abstract
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Koyio LN, WJMvd S, Dimba E, Mulder J, Creugers NHJ, others. "Oral Health Training Programs for Community and Professional Health Care.". 2014. Abstract
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Koyio LN, van der Sanden WJM, Dimba E, Mulder J, Creugers NHJ, Merkx MAW, van der Ven A, Frencken JE. "Oral health training programs for community and professional health care workers in Nairobi East District increases identification of HIV-infected patients." PLoS One. 2014;9:e90927. Abstract
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Muange P, Chindia M, Njiru W, Dimba E, Mutave R, others. "Oral squamous cell carcinoma: A 6-month clinico-histopathologic audit in a Kenyan population." Open Journal of stomatology. 2014;4:475. Abstract
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2013
KS S, FMA B, EAO D. "Calcifying epithelial odontogenic tumour. Anatomy Journal of Africa." Anatomy Journal of Africa. 2013.
H D, EA D, W W, J G, K K. "Digital cancer pathology in Africa." Lancet Oncol. 2013.
Dimba E;, Chindia ML;, Ikito A;, Butt FMA. "Ipsilateral Synchronous Manifestation of an Hiv-Infection Associated Plunging Ranula and Sublingual Salivary Gland Sialocoele: A Review and Case Report.". 2013. Abstract

Plunging ranula is a rare lesion and even more in HIV-infected patients. There has been only one case documented in a 15-year old that had the vertical form HIV-infection. We report a plunging ranula occurring simultaneously with a sublingual salivary gland sialocoele as two separate lesions in an HIV-infected female patient.

Gallie BL, Chan HSL, White A, Gronsdahl P, Dimba EAO, Kimani K, Dimaras H. "Retinoblastoma.". 2013. Abstract

Retinoblastoma is an aggressive eye cancer of infancy and childhood. Survival and the chance of saving vision depend on severity of disease at presentation. Retinoblastoma was the first tumour to draw attention to the genetic aetiology of cancer. Despite good understanding of its aetiology, mortality from retinoblastoma is about 70% in countries of low and middle income, where most affected children live. Poor public and medical awareness, and an absence of rigorous clinical trials to assess innovative treatments impede progress. Worldwide, most of the estimated 9000 newly diagnosed patients every year will die. However, global digital communications present opportunities to optimise standards of care for children and families affected by this rare and often devastating cancer. Parents are now leading the effort for widespread awareness of the danger of leucocoria. Genome-level technologies could make genetic testing a reality for every family affected by retinoblastoma. Best-practice guidelines, online sharing of pathological images, point-of-care data entry, multidisciplinary research, and clinical trials can reduce mortality. Most importantly, active participation of survivors and families will ensure that the whole wellbeing of the child is prioritised in any treatment plan.

Dimba EAO, Guthua SW. "25. Oral Squamous Cell Carcinoma." NATIONAL GUIDELINES FOR CANCER MANAGEMENT KENYA. 2013:144. Abstract
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Kihara E, Owino R, Otwoma J, Dimba E, Chindia M, others. "Calcifying cystic odontogenic tumour manifesting in the maxillary antrum: Case report." Open Journal of Stomatology. 2013;3:504-506. Abstract
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Chindia M, Dimba E, Otwoma J, Owino R, Kihara E. "Calcifying cystic odontogenic tumour manifesting in the maxillary antrum: Case report.". 2013. Abstract
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Shah KS, Butt FMA, Dimba EAO. "Case Report: Calcifying epithelial odontogenic tumor (Pindborg tumor)." Anatomy Journal of Africa. 2013;2:135-136. Abstract
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Dimaras H, Dimba EAO, Waweru W, Githanga J, Kimani K. "Digital cancer pathology in Africa." The Lancet Oncology. 2013;14:e289-e290. Abstract
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Simiyu BN, Butt F, Dimba EA, Wagaiyu EG, Awange DO, Guthua SW, Slootweg PJ. "Keratocystic odontogenic tumours of the jaws and associated pathologies: a 10-year clinicopathologic audit in a referral teaching hospital in Kenya." Journal of Cranio-Maxillofacial Surgery. 2013;41:230-234. Abstract
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Dimba E. "Retinoblastoma.". 2013. Abstract
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2012
Butt FM, Ogengo J, Bahra J, Chindia ML, Wagaiyu E. "19-year audit of benign jaw tumours and tumour-like lesions in a teaching hospital in Nairobi, Kenya.". 2012. AbstractWebsite

Background: The diversity of benign jaw tumours may cause difficulty in a correct diagnosis and insti-tution of an appropriate treatment. Data on the prevalence of these tumours is scarce from the Afri-can continent. We present a 19-year audit of benign jaw tumours and tumour-like lesions at a University teaching hospital in Nairobi, Kenya. Methods: Histo-pathological records were retrieved and re-examined from the Department of Oral and Maxillofacial pa-thology, University of Nairobi from 1992 to 2011. The jaw tumours were classified according to the latest WHO classification. Results: During the 19-year audit, 4257 biopsies were processed of which 597 (14.02%) were jaw tumours within an age range of between 4 to 86 years. There was greater number of odontogenic tumours 417 (69.85%) than the bone related lesions 180 (30.15%). Of the odontogenic tumours, the epithet- lial and in the bone related types, the fibro-osseous lesions were frequent. Conclusion: Ameloblastoma and ossifying fibroma were the most frequent tumours reported in this audit. The information regarding the prevalence of these tumours is scarce from the conti-nent and can be useful in early detection and man-agement before they cause facial deformity.

Butt FM, Ogeng'o JA, Bahra J, Chindia ML, Dimba EAO, Wagaiyu E. "19-year Audit of BenignJaw Tumours and Tumour-like Lesions in a Teaching Hospital in Nairobi, Kenya.". 2012. Abstract
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Dimaras H, Kimani K, Dimba E. "Aet al." Lancet. 2012;379:1436-1446. Abstract
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Odhiambo WA, Akama MK, Guthua SW, Dimba EAO. "Aetiology, pattern and management of oral and maxillofacial injuries at Mulago National Referral Hospital." East African Medical Journal. 2012;89:351-358. Abstract
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Okumu SB, Chindia ML, Gathece LW, Dimba EAO, Odhiambo W. "Clinical features and types of paediatric orofacial malignant neoplasms at two hospitals in Nairobi, Kenya." Journal of Cranio-Maxillofacial Surgery. 2012;40:e8-e14. Abstract
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Simiyu BN, Butt F, Dimba EA, Wagaiyu EG, Awange DO, Guthua Symon W, Slootweg PJ, others. "Keratocystic Odontogenic Tumours of the Jaws and Associated Pathologies.". 2012. Abstract
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Butt FMA, Guthua SW, Awange DA, Dimba EAO, Macigo FG. "The pattern and occurrence of ameloblastoma in adolescents treated at a university teaching hospital, in Kenya: a 13-year study." Journal of Cranio-Maxillofacial Surgery. 2012;40:e39-e45. Abstract
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Dimaras H, Kimani K, Dimba EAO, Gronsdahl P, White A, Chan HSL, Gallie BL. "Retinoblastoma." The Lancet. 2012;379:1436-1446. Abstract
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2011
Wakoli KA, Vilembwa M, Awange DO, Dimba EAO, Mamujee A, Limo A, Gichana J, Chindia ML. "Burning Mouth Syndrome presenting with Oral Lichen Planus–Case Report." JOURNAL OF THE KENYA DENTAL ASSOCIATION. 2011;3:198-200. Abstract
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Kamau MW, Chindia ML, Dimba EA, Awange D, others. "Clinico-Histopathologic types of Maxillofacial Malignancies with emphasis on sarcomas.". 2011. Abstract
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Kamau MW, Chindia ML, Dimba EAO, Awange D, Gathece L. "Clinico-histopathologic types of maxillofacial malignancies with emphasis on sarcomas: A 10-year review." East African Medical Journal. 2011;88:39-45. Abstract
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Johnson NW, Warnakulasuriya S, Gupta PC, Dimba E, Chindia M, Otoh EC, Sankaranarayanan R, Califano J, Kowalski L. "Global oral health inequalities in incidence and outcomes for oral cancer: causes and solutions." Advances in dental research. 2011;23:237-246. Abstract
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Butt FMA, Guthua SW, Nganga P, Edalia M, Dimba EAO. "One-stage treatment of acquired facial deformity caused by severe unilateral condylar hyperplasia." Journal of Craniofacial Surgery. 2011;22:1966-1968. Abstract
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Butt F, Bahra J, Dimba E, Ogeng'o JA, Waigayu E, others. "The pattern of benign jaw tumours in a university teaching hospital in kenya: A 19-year audit.". 2011. Abstract
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Chindia ML, Dimba EA, Otwoma JG, Muriithi JM, Limo AK. pleomorphic salivary adenoma-a 10 year case series.; 2011. Abstract
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2010
2009
Awange DO, Wakoli KA, Onyango JF, Dimba E, Chindia ML. "Ameloblastoma of the jaws in Kenyan children–a review of seventy cases.". 2009. Abstract
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Bredholt T, Dimba EAO, Hagland HR, Wergeland L, Skavland J, Fossan KO, Tronstad KJ, Johannessen AC, Vintermyr OK, Gjertsen BT. "Camptothecin and khat (Catha edulis Forsk.) induced distinct cell death phenotypes involving modulation of c-FLIPL, Mcl-1, procaspase-8 and mitochondrial function in acute myeloid leukemia cell lines." Molecular cancer. 2009;8:1-13. Abstract
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Komu P, Dimba EAO, Macigo FG, Ogwell AEO. "Cigarette smoking and oral health among healthcare students." East African Medical Journal. 2009;86. Abstract
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Ogwell AEO, Dimba E, Komu P, others. "Cigarette Smoking and Oral Health among healthcare students.". 2009. Abstract
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Dimba EAO. "Plan of radiotherapy management of head and neck cancer." East African Medical Journal. 2009;86. Abstract
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Awange DO, Wakoli KA, Onyango JF, Chindia ML, Dimba EO, Guthua SW. "Reactive localised inflammatory hyperplasia of the oral mucosa." East African medical journal. 2009;86. Abstract
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2008
Adeline VL, Dimba EAO, Wakoli KA, Njiru AK, Awange DO, Onyango JF, Chindia ML. "Clinicopathologic features of ameloblastoma in Kenya: a 10-year audit." Journal of Craniofacial Surgery. 2008;19:1589-1593. Abstract
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Johannessen AC, Vintermyr OK, Gjertsen BT, Bredholt T, Neppelberg E, Dimba EA, Costea D. "Khat induces G1-phase arrest and increased expression of stress-sensitive p53 and p16 proteins in normal human oral keratinocytes and fibroblasts.". 2008. Abstract
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Lukandu OM, Costea DE, Dimba EA, Neppelberg E, Bredholt T, Gjertsen BT, Vintermyr OK, Johannessen AC. "Khat induces G1-phase arrest and increased expression of stress-sensitive p53 and p16 proteins in normal human oral keratinocytes and fibroblasts." European journal of oral sciences. 2008;116:23-30. Abstract
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Onyango JF, Awange DO, Wakoli KA, Dimba EA. "lining: A case report." Journal of Maxillofacial & Oral Surgery. 2008;7. Abstract
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Limo AK, Rugutt-Korir A, Gichana JO, Dimba EA, Chindia ML, Mutuma GZ. "Occurance of head and neck cancers at the Nairobi Cancer Registry in Kenya 2000-2002.". 2008. Abstract
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Dimba EA, Chindia ML, Nyanchoka INI, Macigo FGI, others. "The Oral and Dental effects of Khat chewing in the Eastleigh area of Nairobi.". 2008. Abstract
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Dimba EA, Moshy J, Limo A, Otwoma JG, others. "Synchronous Occurrence of Ossifying Fibroma of the Mandible and Maxilla.". 2008. Abstract
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Chindia ML, Dimba EAO, Moshy J, Limo A, Otwoma JG, Guthua SW. "Synchronous occurrence of ossifying fibroma of the mandible and maxilla: a case report." Dental Update. 2008;35:705-707. Abstract
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Dimba EA, Moshy J, Limo A, Otwoma JG, Guthua Symon W. "Synchronous Occurrence of Ossifying Fibroma of the Mandible and Maxilla: A Case Report.". 2008. Abstract
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2007
Dimba EAO, Gichana J, Limo AK, Wakoli KA, Chindia ML, Awange DO. "An audit of oral diseases at a Nairobi centre, 2000–2004." International dental journal. 2007;57:439-444. Abstract
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Lukandu O, Dimba E, Vintermyr O, Costea D, Johannessen A. "P221 Khat inhibits proliferation of normal oral keratinocytes in monolayers and organotypic cultures." Oral Oncology Supplement. 2007;1:198. Abstract
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Butt FM, Chindia ML, Dimba EA, Owino RO. "Paediatric HIV-infection associated oral Karposi$\backslash$'s Sarcome-a report of two cases." African Journal of Oral Health Sciences. 2007;5:5-7. Abstract
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2006
Oral Cancer In Kenya. In Solid Tissue Tumours Handbook.. Nairobi: University of Nairobi; 2006.
Limo A, Gichana J, Korir A, Dimba E, Wakoli K, Awange D, Mutuma G. "Incidence rates of head and neck cancers in Nairobi Kenya.". 2006. Abstract
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Dimba EAO, Guthua SW, Chindia ML. Oral Cancer In Kenya. In Solid Tissue Tumours Handbook.. University of Nairobi; 2006. Abstract
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Dimba E, Aden A, Ndolo U, Chindia ML. "Socio-Economic effects of Khat (Catha edulis) chewing.". 2006. Abstract
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Aden A, Dimba EAO, Ndolo UM, Chindia ML. "Socio-economic effects of khat chewing in north eastern Kenya." East African medical journal. 2006;83:69. Abstract
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2005
2004
2003
O K V, A C J, G W F, B T G, E D. "Catha edulis (khat) induces cell death by apoptosis in leukemia cell lines.". 2003. AbstractWebsite

Khat is the Celastraceus edulis plant, a flowering evergreen tree or large shrub, which grows in the Horn of Africa and southwestern Arabia. Khat use has been associated with development of oral cancer, but its molecular effects remain controversial. This study describes a novel cytotoxic effect of whole khat extract on three leukemia cell lines. Cells were exposed to khat extract and harvested for analysis by fluorescent and electron microscopy, trypan blue exclusion, as well as immunoblotting to characterize the mode of cell death. In a separate series, cells were pretreated with a panel of caspase inhibitors for possible inhibitory effects. Khat induced a rapid cell death effect in HL-60, Jurkat, and NB4 cells that occurred within 2 h of exposure. The treated cells retained their ability to exclude trypan blue dye, a key feature in the apoptotic process. Exposed cells consistently developed morphological features of manifest apoptosis. Z-VAD, a pan-caspase inhibitor, completely inhibited toxic activity for up to 8 h, with partial inhibition by other caspase-specific agents. Western blot analysis showed specific cleavage of caspase-3 in khat-exposed cells. This study shows that khat induces cell death by apoptosis in a process sensitive to inhibition by caspase inhibitors, suggesting that subcellular interactions could be of particular relevance for the biological effects of khat in the cell death process and possibly carcinogenesis

Dimba E, Gjertsen BT, Francis GW, Johannessen AC, Vintermyr OK. "Catha edulis (Khat) induces cell death by apoptosis in leukemia cell lines." Annals of the New York Academy of Sciences. 2003;1010:384-388. Abstract
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Vintermyr OK, Costea DE, Loro LL, Dimba EAO, Johannessen AC. "Crucial effects of fibroblasts and keratinocyte growth factor on morphogenesis of reconstituted human oral epithelium." Journal of investigative dermatology. 2003;121:1479-1486. Abstract
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Costea DE, Loro LL, Dimba EAO, Karsten V, Johannessen AC, others. "ORIGINAL ARTICLE Crucial Effects of Fibroblasts and Keratinocyte Growth Factor on Morphogenesis of Reconstituted Human Oral Epithelium." Journal of Investigative Dermatology. 2003;121. Abstract
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2002
Dimba E. "Khat and Oral Cancer.". 2002.
Costea DE, Dimba E, Loro LL, Johannessen AC, Vintermyr OK. "Proliferation and differentiation in organotypic serum free cultures of normal human oral mucosa.". 2002.
Dimba E. "Khat and Oral Cancer.". 2002. Abstract
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Costea DE, Dimba E, Loro LL, Johannessen AC, Vintermyr OK. "Proliferation and differentiation in organotypic serum free cultures of normal human oral mucosa.". 2002. Abstract
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2000
1999
Dimba E, Chindia ML, Ngovo C, Patel S, Muriithi MW. "Neural tumours of the neck and craniofacial region.". In: JOURNAL OF DENTAL RESEARCH. Vol. 78. AMER ASSOC DENTAL RESEARCH 1619 DUKE ST, ALEXANDRIA, VA 22314 USA; 1999:. Abstract
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