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Publications


2015

Naidoo, S, Dimba E, Yengopal V, Folayan MO, Akpata ES.  2015.  Strategies for Oral Health Research in Africa and the Middle Eastern Region., 2015 Jul. Advances in dental research. 27(1):43-9. Abstractstrategies_for_oral_health_research_in_africa_and_the_middle_eastern_region_-_abstract.pdf

The highest burden of diseases worldwide is in low- and middle-income countries, but due to lack of capacity and inadequate infrastructure, research output from these countries is unable to address existing and emerging challenges in health care. Oral health research has particularly been hampered by low prioritization, resulting in insufficient development of this sector. There is an urgent need for research correlating oral health to upstream social and environmental determinants and promoting the common risk factor approach for prevention of noncommunicable diseases. Population-wide preventive measures for oral health care are more effective than purely curative approaches, especially for vulnerable groups who have limited access to information and appropriate health care. This article identifies priorities and proposes strategies for researchers, stakeholders, and policy makers for the initiation and sustenance of appropriate oral health care research. The proposed interventions are intended to promote collaboration, capacity building, and health advocacy. Local ownership in multinational research projects in low- and middle-income countries, complemented by skills transfer from high-income countries, is encouraged to ensure that regional health needs are addressed. Emphasis is placed on a shift toward translational research that has a direct impact on oral health care systems.

2013

Dimba, E;, Chindia ML;, Ikito A;, Butt FMA.  2013.  Ipsilateral Synchronous Manifestation of an Hiv-Infection Associated Plunging Ranula and Sublingual Salivary Gland Sialocoele: A Review and Case Report. Abstract

Plunging ranula is a rare lesion and even more in HIV-infected patients. There has been only one case documented in a 15-year old that had the vertical form HIV-infection. We report a plunging ranula occurring simultaneously with a sublingual salivary gland sialocoele as two separate lesions in an HIV-infected female patient.

Gallie, BL, Chan HSL, White A, Gronsdahl P, Dimba EAO, Kimani K, Dimaras H.  2013.  Retinoblastoma. Abstract

Retinoblastoma is an aggressive eye cancer of infancy and childhood. Survival and the chance of saving vision depend on severity of disease at presentation. Retinoblastoma was the first tumour to draw attention to the genetic aetiology of cancer. Despite good understanding of its aetiology, mortality from retinoblastoma is about 70% in countries of low and middle income, where most affected children live. Poor public and medical awareness, and an absence of rigorous clinical trials to assess innovative treatments impede progress. Worldwide, most of the estimated 9000 newly diagnosed patients every year will die. However, global digital communications present opportunities to optimise standards of care for children and families affected by this rare and often devastating cancer. Parents are now leading the effort for widespread awareness of the danger of leucocoria. Genome-level technologies could make genetic testing a reality for every family affected by retinoblastoma. Best-practice guidelines, online sharing of pathological images, point-of-care data entry, multidisciplinary research, and clinical trials can reduce mortality. Most importantly, active participation of survivors and families will ensure that the whole wellbeing of the child is prioritised in any treatment plan.

2012

Dimba, EAO, Butt FMA, Shah KS.  2012.  Calcifying epithelial odontogenic tumor (pindborg tumor). Website
Butt, FM, Ogengo J, Bahra J, Chindia ML, Wagaiyu E.  2012.  19-year audit of benign jaw tumours and tumour-like lesions in a teaching hospital in Nairobi, Kenya. AbstractWebsite

Background: The diversity of benign jaw tumours may cause difficulty in a correct diagnosis and insti-tution of an appropriate treatment. Data on the prevalence of these tumours is scarce from the Afri-can continent. We present a 19-year audit of benign jaw tumours and tumour-like lesions at a University teaching hospital in Nairobi, Kenya. Methods: Histo-pathological records were retrieved and re-examined from the Department of Oral and Maxillofacial pa-thology, University of Nairobi from 1992 to 2011. The jaw tumours were classified according to the latest WHO classification. Results: During the 19-year audit, 4257 biopsies were processed of which 597 (14.02%) were jaw tumours within an age range of between 4 to 86 years. There was greater number of odontogenic tumours 417 (69.85%) than the bone related lesions 180 (30.15%). Of the odontogenic tumours, the epithet- lial and in the bone related types, the fibro-osseous lesions were frequent. Conclusion: Ameloblastoma and ossifying fibroma were the most frequent tumours reported in this audit. The information regarding the prevalence of these tumours is scarce from the conti-nent and can be useful in early detection and man-agement before they cause facial deformity.

2011

2010

2009

2008

2006

  2006.  Oral Cancer In Kenya. In Solid Tissue Tumours Handbook.. , Nairobi: University of Nairobi

2005

2004

2003

O K, V, A C J, G W F, B T G, E D.  2003.  Catha edulis (khat) induces cell death by apoptosis in leukemia cell lines. AbstractWebsite

Khat is the Celastraceus edulis plant, a flowering evergreen tree or large shrub, which grows in the Horn of Africa and southwestern Arabia. Khat use has been associated with development of oral cancer, but its molecular effects remain controversial. This study describes a novel cytotoxic effect of whole khat extract on three leukemia cell lines. Cells were exposed to khat extract and harvested for analysis by fluorescent and electron microscopy, trypan blue exclusion, as well as immunoblotting to characterize the mode of cell death. In a separate series, cells were pretreated with a panel of caspase inhibitors for possible inhibitory effects. Khat induced a rapid cell death effect in HL-60, Jurkat, and NB4 cells that occurred within 2 h of exposure. The treated cells retained their ability to exclude trypan blue dye, a key feature in the apoptotic process. Exposed cells consistently developed morphological features of manifest apoptosis. Z-VAD, a pan-caspase inhibitor, completely inhibited toxic activity for up to 8 h, with partial inhibition by other caspase-specific agents. Western blot analysis showed specific cleavage of caspase-3 in khat-exposed cells. This study shows that khat induces cell death by apoptosis in a process sensitive to inhibition by caspase inhibitors, suggesting that subcellular interactions could be of particular relevance for the biological effects of khat in the cell death process and possibly carcinogenesis

2002

Costea, DE, Dimba E, Loro LL, Johannessen AC, Vintermyr OK.  2002.  Proliferation and differentiation in organotypic serum free cultures of normal human oral mucosa.
Dimba, E.  2002.  Khat and Oral Cancer..

2000

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