Publications

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2001
KIAMBI PROFKANGETHEE. "CASEOUS LYPMHADENITIS IN GOATS: THE PTHOGENESIS,INCUBATION PERIOD AND SEROLOGICAL RESPONSE AFTER EXPERIMENTAL INFECTION.". In: journal. Kisipan, M.L.; 2001. Abstract
Twenty goats in two groups of 10 were injected intradermally, with Corynebacterium pseudotuberculosis. The doses of infection were 1x105 and 5x104 colony forming units for groups 1 and 2 respectively. Thereafter, a goat from each group was killed every 2-3 days and examined for gross and microscopic caseous lesions in the draining lymph nodes. Bands or zones of macrophages and polymorphonuclear granulocytes were observed on the second day of infection in both groups. Gross caseous lesions were observed from day 8 and 9 of infection respectively. Positive bacterial agglutination test and haemolysin inhibition test titres were detected after 15-17days and 20 -25 days of infection respectively. These results indicated that caseous lymphadenitis is a subacute disease with an incubation period of 8-9 days but it is not detectable serologically until after 15 days of infection.
1998
KIAMBI PROFKANGETHEE. "CASEOUS LYMPHADENITIS IN GOATS: THE DOSE OF INFECTION AND SEROLOGICAL RESPONSE.". In: journal. Kisipan, M.L.; 1998. Abstract
Goats were infected intradermally with caseous pus containing between 1x105 and 5x101 colony forming units (CFU) of Corynebacterium pseudotuberculosis. Animals infected with doses of equal and above 1x105 CFU of the organism developed caseous lesions in the regional draining lymph nodes. On serological examination, 3/6 animals infected with equal or less than 1x101 CFU and 2/4 infected with equal or less than 1x102 CFU had no positive bacterial agglutination and antitoxin antibody titres respectively. These results indicated that caseous lymphadenitis (CLA) is a highly contagious disease since relatively low doses (1x102 CFU) of C.pseudotuberculosis injected intradermally could induce CLA lesions in draining lymph nodes. The serological response in terms of rate and extent appeared to depend on the dose of infection.
1997
KIAMBI PROFKANGETHEE. "CLINICAL, SEROLOGICAL AND PATHOLOGICAL RESPONSE IN GOATS INFECTED WITH CORYNEBACTERIUM PSEUDOTUBERCULOSIS THROUGH CUTANEOUS AND SUBCUTANEOUS ROUTES.". In: journal. Kisipan, M.L.; 1997. Abstract
Goats were injected with caseous pus containing 106 colony forming units CFU of C. pseudotuberculosis either subcutaneously (s/c), intradermally (i/d) or smeared with caseous pus on either scarified or intact skin. All animals were then examined regulary for clinical abnormalities and also for antibodies to C. pseudotuberculosis. All animals were sacrificed 10 weeks after infection and examined for caseous lymphadenitis (CLA) lesions.  Acute lameness was observed in all animals infected s/c but not in the other groups. The regional draining lymph nodes were detected palpably swollen by day three post infection in all animals infected i/d and in one infected on scarified skin. The route of infection did not influence the onset of serological response but animals infected i/d had more rapid and higher response. At post mortem, animals infected s/c; i/d or on scarified skin had abscesses in the regional draining lymph nodes but those infected on intact skin had none. These results indicted that CLA can be transmitted through either s/c, i/d or through scarified skin but that infection through intact skin was unlikely. The disease induced by i/d injection or on scarified skin was more typical of the natural disease in that it had no acute clinical signs.
1995
KIAMBI PROFKANGETHEE. "COMPARATIVE ULTRASTRUCTURAL STUDIES ON BESNOITIA BESNOITI AND BESNOITIA CAPRAE.". In: journal. Kisipan, M.L.; 1995. Abstract
Comparative transmission electron microscopy on Besnoitia besnoiti and on a strain of Besnoitia derived from goats in Kenya revealed that the two organisms differ in their pellicle, micropore, microtubules, nucleus, wall-forming body 1 (W1), amount of lipids and amylopectin. Thus the caprine besnoitia is probably a different organism and the term Besnoitia caprae should continue to be used.   Keywords; Besnoitia besnoiti, Besnoitia caprae, cystozoite, goat, ultrastructure, speciation 

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