CLINICAL, SEROLOGICAL AND PATHOLOGICAL RESPONSE IN GOATS INFECTED WITH CORYNEBACTERIUM PSEUDOTUBERCULOSIS THROUGH CUTANEOUS AND SUBCUTANEOUS ROUTES

Citation:
KIAMBI PROFKANGETHEE. "CLINICAL, SEROLOGICAL AND PATHOLOGICAL RESPONSE IN GOATS INFECTED WITH CORYNEBACTERIUM PSEUDOTUBERCULOSIS THROUGH CUTANEOUS AND SUBCUTANEOUS ROUTES.". In: journal. Kisipan, M.L.; 1997.

Abstract:

Goats were injected with caseous pus containing 106 colony forming units CFU of C. pseudotuberculosis either subcutaneously (s/c), intradermally (i/d) or smeared with caseous pus on either scarified or intact skin. All animals were then examined regulary for clinical abnormalities and also for antibodies to C. pseudotuberculosis. All animals were sacrificed 10 weeks after infection and examined for caseous lymphadenitis (CLA) lesions.  Acute lameness was observed in all animals infected s/c but not in the other groups. The regional draining lymph nodes were detected palpably swollen by day three post infection in all animals infected i/d and in one infected on scarified skin. The route of infection did not influence the onset of serological response but animals infected i/d had more rapid and higher response. At post mortem, animals infected s/c; i/d or on scarified skin had abscesses in the regional draining lymph nodes but those infected on intact skin had none. These results indicted that CLA can be transmitted through either s/c, i/d or through scarified skin but that infection through intact skin was unlikely. The disease induced by i/d injection or on scarified skin was more typical of the natural disease in that it had no acute clinical signs.

Notes:

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