M DRSENERWADANIEL. "
ANTIMICROBIAL RESISTANCE OF ENTEROPATHOGENIC ESCHERICHIA COLI STRAINS FROM A NOSOCOMIAL OUTBREAK IN KENYA.". In:
East African Journal of Ophthalmology. Nyenze E, Ilako D, Kimani K; 1989.
Abstractisolated from preterm neonates during the outbreak of gastroenteritis in hospital in Nairobi, Kenya, were resistance to trimethoprin-sulfathoxaxole, Chloramphenicol, oxytetracycline and ampicilin, but only a few strains were resistant to cefazolin, cefamandole, cefataximine, amikacin and nalidixic acid. Fourteen different antimicrobial resistance patterns were observed in the 229 strains of E.coli analyzed. Eighty-two percent of the EPEC strains belonged to two resistance patterns. There was no consistent relationship between palsmid profile group and antimicrobial resistance pattern, although one resistance pattern was more frequently observed in EAF-positive strins belonging to the dominant plasmid profile group. Nine percent of the EPEC strins were resistant to gentamicin compared to 37% in the non-EPEC group. No correlation was observed between administration of gentamicin and percentage of resistant strains isolated. None of the nine neonates receiving gentamicin died during the outbreak. Gentamicin resistance was observed in E.coli strains from six out of these nine neonates. Five out of fourteen neonates who received other antimicrobials, or no antibiotic at all, died.
Key words: Enteropathogenic Escherichia Coli; antimicrobial resistance;
M DRSENERWADANIEL. "
Colonization of Neonates in a Nursery Ward with Enteropathogenic Escherichia coli and Correlation to the Clinical Histories of the Children.". In:
East African Journal of Ophthalmology. Nyenze E, Ilako D, Kimani K; 1989.
AbstractStool samples were examined from 30 preterm to a nursery ward; 16 neonates had diarrhea 12 constituted an aged-matched control group without diarrhea, and had an unknown history regarding diarrhea. Variable number of enteropathogenic Escherichia coli serotype0111:HNT strains possessing the gene coding for the enteroadherence factor(EAF) were found in stool samples from 13 of the neonates. No other microbiological enteropathogen was found. A total of 294 strains (9 or 10from each neonate, comprising 229 E. coli and 65 Klebsiella pneumonia strains) were characterized with respect to plsmid content and grouped into 37 plasmid profile groups. Diarrhea was found not to be correlated with any specific plasmid profile or with the number of EAF-positive strains but rather with the number of strains with one specific plasmid profile or with the number of EAF-positive strains (of the 9 or 10 strains) isolated from each stool sample. All the neonates who died had diarrhea (5 died of 16 with diarrhea); all five of the neonates who died possessed strains with one specific plasmid profile group, and EAF-positive strains were isolated from four of them .of the seven neonates from whom seven or more EAF-positive isolates were isolated, three died, compared with only one of five of those whom only few (1 to 3 of 10)EAF-positive strains were isolated. Both plasmid profiling and genetic probing with the EAF-positive probe were found to be good alternatives when serotyping is not available for identification of 0111:HNT enteropathogenic E.coli strains.
M DRSENERWADANIEL. "
Diamiano, A.W., M. Kagiko, M. Kayihura and D. Senerwa (1989). Aeromonas species from fish from Kenyan waters. Proceedings of the 3rd African Conference on Diarrhoeal Diseases: 55-57.". In:
East African Journal of Ophthalmology. Nyenze E, Ilako D, Kimani K; 1989.
Abstractisolated from preterm neonates during the outbreak of gastroenteritis in hospital in Nairobi, Kenya, were resistance to trimethoprin-sulfathoxaxole, Chloramphenicol, oxytetracycline and ampicilin, but only a few strains were resistant to cefazolin, cefamandole, cefataximine, amikacin and nalidixic acid. Fourteen different antimicrobial resistance patterns were observed in the 229 strains of E.coli analyzed. Eighty-two percent of the EPEC strains belonged to two resistance patterns. There was no consistent relationship between palsmid profile group and antimicrobial resistance pattern, although one resistance pattern was more frequently observed in EAF-positive strins belonging to the dominant plasmid profile group. Nine percent of the EPEC strins were resistant to gentamicin compared to 37% in the non-EPEC group. No correlation was observed between administration of gentamicin and percentage of resistant strains isolated. None of the nine neonates receiving gentamicin died during the outbreak. Gentamicin resistance was observed in E.coli strains from six out of these nine neonates. Five out of fourteen neonates who received other antimicrobials, or no antibiotic at all, died.
Key words: Enteropathogenic Escherichia Coli; antimicrobial resistance;
M DRSENERWADANIEL. "
Olsvik, O., Senerwa, D., J.M. Gathuma and L.N. Mutanda (1989). An outbreak of enteropathogenic Escherichia coli 0111:HNT among preterm neonates in a hospital in Nairobi, Kenya. Proceedings of the 3rd African Conference on Diarrhoeal Diseases: 19-25.". In:
East African Journal of Ophthalmology. Nyenze E, Ilako D, Kimani K; 1989.
Abstractisolated from preterm neonates during the outbreak of gastroenteritis in hospital in Nairobi, Kenya, were resistance to trimethoprin-sulfathoxaxole, Chloramphenicol, oxytetracycline and ampicilin, but only a few strains were resistant to cefazolin, cefamandole, cefataximine, amikacin and nalidixic acid. Fourteen different antimicrobial resistance patterns were observed in the 229 strains of E.coli analyzed. Eighty-two percent of the EPEC strains belonged to two resistance patterns. There was no consistent relationship between palsmid profile group and antimicrobial resistance pattern, although one resistance pattern was more frequently observed in EAF-positive strins belonging to the dominant plasmid profile group. Nine percent of the EPEC strins were resistant to gentamicin compared to 37% in the non-EPEC group. No correlation was observed between administration of gentamicin and percentage of resistant strains isolated. None of the nine neonates receiving gentamicin died during the outbreak. Gentamicin resistance was observed in E.coli strains from six out of these nine neonates. Five out of fourteen neonates who received other antimicrobials, or no antibiotic at all, died.
Key words: Enteropathogenic Escherichia Coli; antimicrobial resistance;
M DRSENERWADANIEL. "
Olsvik, O., Senerwa, D., J.M. Gathuma and L.N. Mutanda (1989). Intestinal colonization of neonates with enteropathogenic Escherichia coli and the correlation to the childrens clinical history. Proceedings of the 3rd African Conference on Diarrhoeal Diseas.". In:
East African Journal of Ophthalmology. Nyenze E, Ilako D, Kimani K; 1989.
Abstractisolated from preterm neonates during the outbreak of gastroenteritis in hospital in Nairobi, Kenya, were resistance to trimethoprin-sulfathoxaxole, Chloramphenicol, oxytetracycline and ampicilin, but only a few strains were resistant to cefazolin, cefamandole, cefataximine, amikacin and nalidixic acid. Fourteen different antimicrobial resistance patterns were observed in the 229 strains of E.coli analyzed. Eighty-two percent of the EPEC strains belonged to two resistance patterns. There was no consistent relationship between palsmid profile group and antimicrobial resistance pattern, although one resistance pattern was more frequently observed in EAF-positive strins belonging to the dominant plasmid profile group. Nine percent of the EPEC strins were resistant to gentamicin compared to 37% in the non-EPEC group. No correlation was observed between administration of gentamicin and percentage of resistant strains isolated. None of the nine neonates receiving gentamicin died during the outbreak. Gentamicin resistance was observed in E.coli strains from six out of these nine neonates. Five out of fourteen neonates who received other antimicrobials, or no antibiotic at all, died.
Key words: Enteropathogenic Escherichia Coli; antimicrobial resistance;