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2020
Nunow A, Nzioka JM, Kinama JM. "Analysis of gender parity in climate change adaptation actions within Kajiado and Kiambu counties, Kenya." East African Journal of Science, Technology and Innovation. 2020;1(2).
Gichure M, Onono J, Wahome R, Gathura P. "Analysis of the benefits and production challenges of working donkeys in smallholder farming systems in Kenya." Veterinary World. 2020;13(11).
Collaborators TWHOACTIONT. "Antenatal Dexamethasone for Early Preterm Birth in Low-Resource Countries." New England Medical Journal. 2020;382(17). AbstractWebsite

Abstract

Background: The safety and efficacy of antenatal glucocorticoids in women in low-resource countries who are at risk for preterm birth are uncertain.

Methods: We conducted a multicountry, randomized trial involving pregnant women between 26 weeks 0 days and 33 weeks 6 days of gestation who were at risk for preterm birth. The participants were assigned to intramuscular dexamethasone or identical placebo. The primary outcomes were neonatal death alone, stillbirth or neonatal death, and possible maternal bacterial infection; neonatal death alone and stillbirth or neonatal death were evaluated with superiority analyses, and possible maternal bacterial infection was evaluated with a noninferiority analysis with the use of a prespecified margin of 1.25 on the relative scale.

Results: A total of 2852 women (and their 3070 fetuses) from 29 secondary- and tertiary-level hospitals across Bangladesh, India, Kenya, Nigeria, and Pakistan underwent randomization. The trial was stopped for benefit at the second interim analysis. Neonatal death occurred in 278 of 1417 infants (19.6%) in the dexamethasone group and in 331 of 1406 infants (23.5%) in the placebo group (relative risk, 0.84; 95% confidence interval [CI], 0.72 to 0.97; P=0.03). Stillbirth or neonatal death occurred in 393 of 1532 fetuses and infants (25.7%) and in 444 of 1519 fetuses and infants (29.2%), respectively (relative risk, 0.88; 95% CI, 0.78 to 0.99; P=0.04); the incidence of possible maternal bacterial infection was 4.8% and 6.3%, respectively (relative risk, 0.76; 95% CI, 0.56 to 1.03). There was no significant between-group difference in the incidence of adverse events.

Conclusions: Among women in low-resource countries who were at risk for early preterm birth, the use of dexamethasone resulted in significantly lower risks of neonatal death alone and stillbirth or neonatal death than the use of placebo, without an increase in the incidence of possible maternal bacterial infection.

Kimondo J, Mutai P, Njogu P, Kimwele C. "Anti-inflammatory activity of selected plants used by the Ilkisonko Maasai, Kenya." Afr. J. Therapeut. Pharmacol. 2020;9(2):39-43.
Derese S. "Anti-inflammatory Flavanones and Flavones from Tephrosia linearis." Journal of natural products. 2020. AbstractWebsite

Anti-inflammatory Flavanones and Flavones from Tephrosia linearis
Richard Oriko Owor, Kibrom Gebreheiwot Bedane, Sebastian Zühlke, Solomon Derese, George Otieno Ong’amo, Albert Ndakala, Michael Spiteller
Abstract
Phytochemical analysis of a methanol–dichloromethane (1:1) extract of the aerial parts of Tephrosialinearis led to the isolation of 18 compounds. Seven of these, namely, lineaflavones A–D (1–4), 6-methoxygeraldone (5), 8″-acetylobovatin (6), and 5-hydroxy-7-methoxysaniculamin A (7) are new compounds. The compounds were characterized based on their NMR and HRMSn data. The anti-inflammatory effects of the crude extract and isolated compounds were evaluated by measuring the levels of interleukins (IL-1β, IL-2, and IL-6), granulocyte-macrophage colony-stimulating factor (GM-CSF), and tumor necrosis factor-α (TNF-α) in lipopolysaccharide (LPS)-stimulated peripheral blood mononuclear cells (PBMCs). The crude extract inhibited the release of all cytokines except IL-1β, which slightly increased in comparison to the LPS control. All the tested compounds suppressed the production of IL-2, GM-CSF, and TNF-α. Whereas compounds 1, 2, 4–8, 10–15, 17, and 18 decreased production of IL-6, compounds 1, 2, 4, 7, 10, 13–15, and 17 inhibited the release of IL-1β. It is worth noting that most of the compounds tested showed a superior reduction in cytokines release compared to the reference drug ibuprofen.

Owor RO, Bedane KG, Zühlke S, Derese S, Ong’amo GO, Ndakala A, Spiteller M. "Anti-inflammatory Flavanones and Flavones from Tephrosia linearis." Journal of Natural Products. 2020;83(4):996-1004. AbstractJournal of Natural Products

Description
Phytochemical analysis of a methanol–dichloromethane (1:1) extract of the aerial parts of Tephrosialinearis led to the isolation of 18 compounds. Seven of these, namely, lineaflavones A–D (1–4), 6-methoxygeraldone (5), 8″-acetylobovatin (6), and 5-hydroxy-7-methoxysaniculamin A (7) are new compounds. The compounds were characterized based on their NMR and HRMSn data. The anti-inflammatory effects of the crude extract and isolated compounds were evaluated by measuring the levels of interleukins (IL-1β, IL-2, and IL-6), granulocyte-macrophage colony-stimulating factor (GM-CSF), and tumor necrosis factor-α (TNF-α) in lipopolysaccharide (LPS)-stimulated peripheral blood mononuclear cells (PBMCs). The crude extract inhibited the release of all cytokines except IL-1β, which slightly increased in comparison to the LPS control. All the tested compounds suppressed the production of IL-2, GM-CSF, and …

Babiaka SB, Nia R, Abuga KO, Mbah JA, Nziko VN, Paper DH, Ntie-Kang F. "Antioxidant potential of flavonoid glycosides from Manniophyton fulvum Müll. (Euphorbiaceae): Identification and molecular modeling." Scientic African. 2020;8(e00423):1-7. Abstract

Chemical investigation of the leaves of Manniophyton fulvum led to the isolation of seven flavonoid glycosides: myricetin-3-O-β-Dd-rhamnoside (1), kaempferol-3-O-β-d-rhamnoside (2), quercetin-3-O-β-d-glucoside (3), quercetin-3-O-β-d-rhamnoside (4), quercetin-3-O-β-d-galactoside (5), rutin (6) and quercetin (7). The structures of the compounds were established by spectroscopic analyses as well as by comparison with published data. Some of the compounds showed strong antioxidant activity which validates the traditional use of the plant. An attempted correlation between the computed HOMO-LUMO energies and the measured antioxidant activities was established. We have also estimated the cardiotoxicity of the compounds by calculating the predicted logarithm of the human Ether-`a-go-go Related Gene (loghERG) using the QikProp program. These purified flavonoids are new potential lead compounds for the development of antioxidant drugs.

Chepkirui C, Ochieng PJ, Sarkar B, Hussain A, Pal C, Yang LJ, Coghi P, Akala HM, Derese S, Ndakala A, Heydenreich M, Wong VKW, Erdélyi Máté, Yenesew A. "Antiplasmodial and antileishmanial flavonoids from Mundulea sericea." Fitoterapia. 2020;149:104796. AbstractFitoterapia

Abstract
Five known compounds (1–5) were isolated from the extract of Mundulea sericea leaves. Similar investigation of the roots of this plant afforded an additional three known compounds (6–8). The structures were elucidated using NMR spectroscopic and mass spectrometric analyses. The absolute configuration of 1 was established using ECD spectroscopy. In an antiplasmodial activity assay, compound 1 showed good activity with an IC50 of 2.0 μM against chloroquine-resistant W2, and 6.6 μM against the chloroquine-sensitive 3D7 strains of Plasmodium falciparum. Some of the compounds were also tested for antileishmanial activity. Dehydrolupinifolinol (2) and sericetin (5) were active against drug-sensitive Leishmania donovani (MHOM/IN/83/AG83) with IC50 values of 9.0 and 5.0 μM, respectively. In a cytotoxicity assay, lupinifolin (3) showed significant activity on BEAS-2B (IC50 4.9 μM) and HePG2 (IC50 10.8 μM) human cell lines. All the other compounds showed low cytotoxicity (IC50 > 30 μM) against human lung adenocarcinoma cells (A549), human liver cancer cells (HepG2), lung/bronchus cells (epithelial virus transformed) (BEAS-2B) and immortal human hepatocytes (LO2)

Graphical abstract
Unlabelled Image

Chepkirui C, Ochieng PJ, Sarkar B, Hussain A, Pal C, Yang LJ, Coghi P, Akala HM, Derese S, Ndakala A, Heydenreich M, Wong VKW, Erdélyi Máté, Yenesew A. "Antiplasmodial and antileishmanial flavonoids from Mundulea sericea." Fitoterapia. 2020;149:104796. AbstractFitoterapia

Description
A new flavanonol, 3-hydroxyerythrisenegalone (1), and four known compounds (2–5) were isolated from the extract of Mundulea sericea leaves. Investigation of the roots of this plant afforded an additional three known compounds (6–8). The structures were elucidated using NMR spectroscopic and mass spectrometric analyses. The absolute configuration of 1 was established using ECD spectroscopy. In an antiplasmodial activity assay, compound 1 showed good activity with an IC50 of 2.0 μM against chloroquine-resistant W2, and 6.6 μM against the chloroquine-sensitive 3D7 strains of Plasmodium falciparum. Some of the compounds were also tested for antileishmanial activity. Dehydrolupinifolinol (2) and sericetin (5) were active against drug-sensitive Leishmania donovani (MHOM/IN/83/AG83) with IC50 values of 9.0 and 5.0 μM, respectively. In a cytotoxicity assay, erythrisenegalone (3) showed significant …

Andima M, Coghi P, Yang LJ, Wong VKW, Ngule CM, Heydenreich M, Ndakala AJ, Yenesew A, Derese S. "Antiproliferative Activity of Secondary Metabolites from Zanthoxylum zanthoxyloides Lam: In vitro and in silico Studies." Pharmacognosy Communications. 2020;10(1). AbstractPharmacognosy Communications

Description
Background: Plant derived compounds have provided proming leads in search for safer anticancer chemotherapies. Zanthoxylum zanthoxyloides is a common medicinal plant in Uganda whose bioactive composition has not been fully elucidated. The aim of this study was to evaluate the in vitro antiproliferative potential of compounds isolated from Zanthoxylum zanthoxyloides and their probable in silico anticancer mechanisms of action. Methods: Column chromatography was used to isolate compounds from MeOH: CH2Cl2 (1: 1) extract of the stem bark extract of Zanthoxylum zanthoxyloides. The structures of the isolated compounds were elucidated by NMR and MS analyses. MTT assay was used to measure cell viability. Using in silico docking, the interaction of the compounds with key target proteins in the p53 pathway was determined. Results: From the root bark of this plant five compounds were isolated, namely; dihydrochelerythrine (1), skimmianine (2), tridecan-2-one (3), sesamin (4) and hesperidin (5). Dihydrochelerythrine (1) inhibited proliferation of liver cancer (HCC) cells (IC50 21.2), breast cancer (BT549) cells,(IC50 21.2 μM). Similarly, sesamin (4) exhibited moderate inhibitory activity against BT549 cancer cells (IC50 47.6 μM). Hesperidin (5) showed low inhibitory activity against A549 and HEp2 (Larynx) cells but was significantly toxic to normal liver and lung cells.
In silico docking studies showed that all the compounds strongly bind to cyclin-dependent kinases (CDK2 and CDK6) and weakly bind to caspases 3 and 8 suggesting that they inhibit cancer cells by inducing cell cycle arrest and apoptosis. Conclusion: This study indicates …

Andima M, Coghi P, Yang LJ, Wong VKW, Ngule CM, Heydenreich M, Ndakala AJ, Yenesew A, Derese S. "Antiproliferative Activity of Secondary Metabolites from Zanthoxylum zanthoxyloides Lam: In vitro and in silico Studies." Pharmacognosy Communications. 2020;10(1). AbstractPharmacognosy Communications

Description
Background: Plant derived compounds have provided proming leads in search for safer anticancer chemotherapies. Zanthoxylum zanthoxyloides is a common medicinal plant in Uganda whose bioactive composition has not been fully elucidated. The aim of this study was to evaluate the in vitro antiproliferative potential of compounds isolated from Zanthoxylum zanthoxyloides and their probable in silico anticancer mechanisms of action. Methods: Column chromatography was used to isolate compounds from MeOH: CH2Cl2 (1: 1) extract of the stem bark extract of Zanthoxylum zanthoxyloides. The structures of the isolated compounds were elucidated by NMR and MS analyses. MTT assay was used to measure cell viability. Using in silico docking, the interaction of the compounds with key target proteins in the p53 pathway was determined. Results: From the root bark of this plant five compounds were isolated, namely; dihydrochelerythrine (1), skimmianine (2), tridecan-2-one (3), sesamin (4) and hesperidin (5). Dihydrochelerythrine (1) inhibited proliferation of liver cancer (HCC) cells (IC50 21.2), breast cancer (BT549) cells,(IC50 21.2 μM). Similarly, sesamin (4) exhibited moderate inhibitory activity against BT549 cancer cells (IC50 47.6 μM). Hesperidin (5) showed low inhibitory activity against A549 and HEp2 (Larynx) cells but was significantly toxic to normal liver and lung cells.
In silico docking studies showed that all the compounds strongly bind to cyclin-dependent kinases (CDK2 and CDK6) and weakly bind to caspases 3 and 8 suggesting that they inhibit cancer cells by inducing cell cycle arrest and apoptosis. Conclusion: This study indicates …

Mureithi PM, B.M. K, Onyango CM, Mathiu MP. "Antiulcerogenic Effects of Selected African Nightshades (Solanum nigrum Linn.) Genotypes on the Rat Stomach: A Morphologic and Morphometric Study." International Journal of Morphology. 2020;38(4):940-946.
Simiyu MT, Nyongesa FW, Aduda BO, Birech Z, Mwebaze G. "Application of An Organic Plant-Derived Binder in the Fabrication of Diatomaceous Earth Waste-Based Membranes for Water Purification Systems." MRS Advances. 2020;5(26):1339-1348.
Ng’ang’a JW, Odero D, Buigutt KSA. "Application of Library Service Charter in Quality Service Delivery in University Libraries." Library Philosophy and Practice (e-journal). . 2020;4007(4007).Website
Kaoga J, Olago D, Ouma G, Ouma G, Onono J. "Appraisal of Land Use Transformation using Remote Sensing in Kajiado County, Kenya." International Journal of Ecology and Environmental Sciences. 2020;46(2):177-186. Abstractenieindia.org

Kajiado County is predominantly inhabited by the Maasai nomadic pastoralists who rely on natural systems for their provisions and production needs. Traditionally, communal land management has been the norm in the area but that has evolved under the swift development context with the private holding of land becoming prevalent. The land-use transformation has curtailed the traditional seasonal movement of livestock and that has exposed the Maasai community to production risks which have contributed to the widespread food insecurity in the area. To address this gap, the study investigated land-use transformation in the area using Landsat 8, 4 and 5 datasets, where 1987, 2000 and 2015 epochs with a spatial resolution of 30*30m were sourced from www.glovis.usgs.org Remote sensing technology used to evaluate biophysical attributes showed changes in land-use patterns with the bare area, built-up area, cropland, forested land, grassland, riverine, shrubland, waterbody and wetland having undergone significant changes in their respective sizes. These land-use transformations have been compounded with the spread of invasive species to the point of threatening pastoralism. However, the successive governments have shown a marked disdain for resource use patterns. Thus, there is need for an all-inclusive land-use policies to inform adaptation and resilience planning in Kajiado County, Kenya.

Keywords

Natural Resource; Pastoralism; Biophysical Attributes, Land-Use Transformation; Remote Sensing; Masai Pastoralists

Kaoga J, Olago D, Ouma G, Ouma G, Onono J. "Appraisal of Land Use Transformation using Remote Sensing in Kajiado County, Kenya." International Journal of Ecology and Environmental Sciences. 2020;46(2):177-186. Abstractnieindia.org

Kajiado County is predominantly inhabited by the Maasai nomadic pastoralists who rely on natural systems for their provisions and production needs. Traditionally, communal land management has been the norm in the area but that has evolved under the swift development context with the private holding of land becoming prevalent. The land-use transformation has curtailed the traditional seasonal movement of livestock and that has exposed the Maasai community to production risks which have contributed to the widespread food insecurity in the area. To address this gap, the study investigated land-use transformation in the area using Landsat 8, 4 and 5 datasets, where 1987, 2000 and 2015 epochs with a spatial resolution of 30*30m were sourced from www.glovis.usgs.org Remote sensing technology used to evaluate biophysical attributes showed changes in land-use patterns with the bare area, built-up area, cropland, forested land, grassland, riverine, shrubland, waterbody and wetland having undergone significant changes in their respective sizes. These land-use transformations have been compounded with the spread of invasive species to the point of threatening pastoralism. However, the successive governments have shown a marked disdain for resource use patterns. Thus, there is need for an all-inclusive land-use policies to inform adaptation and resilience planning in Kajiado County, Kenya.

Keywords

Natural Resource; Pastoralism; Biophysical Attributes, Land-Use Transformation; Remote Sensing; Masai Pastoralists

omari HK, Makokha, Abdalla S. Arabic for all. Nairobi: Chance Publishers; 2020.
Opanda S, Bulimo W, Gachara G, Ekuttan C, Amukoye E. "Assessing antigenic drift and phylogeny of influenza A (H1N1) pdm09 virus in Kenya using HA1 sub-unit of the hemagglutinin gene." PLoS One. 2020;15(2):e0228029. Abstractpone.0228029.pdf

Influenza A (H1N1) pdm09 virus emerged in North America in 2009 and has been established as a seasonal strain in humans. After an antigenic stasis of about six years, new antigenically distinct variants of the virus emerged globally in 2016 necessitating a change in the vaccine formulation for the first time in 2017. Herein, we analyzed thirty-eight HA sequences of influenza A (H1N1) pdm09 strains isolated in Kenya during 2015-2018 seasons, to evaluate their antigenic and molecular properties based on the HA1 sub-unit. Our analyses revealed that the A (H1N1) pdm09 strains that circulated in Kenya during this period belonged to genetic clade 6B, subclade 6B.1 and 6B.2. The Kenyan 2015 and 2016 isolates differed from the vaccine strain A/California/07/2009 at nine and fourteen antigenic sites in the HA1 respectively. Further, those isolated in 2017 and 2018 correspondingly varied from A/Michigan/45/2015 vaccine strain at three and fifteen antigenic sites. The predicted vaccine efficacy of A/California/07/2009 against Kenyan 2015/2016 was estimated to be 32.4% while A/Michigan/45/2015 showed estimated vaccine efficacies of 39.6% - 41.8% and 32.4% - 42.1% against Kenyan 2017 and 2018 strains, respectively. Hemagglutination-inhibition (HAI) assay using ferret post-infection reference antiserum showed that the titers for the Kenyan 2015/2016 isolates were 2-8-fold lower compared to the vaccine strain. Overall, our results suggest the A (H1N1) pdm09 viruses that circulated in Kenya during 2015/2016 influenza seasons were antigenic variants of the recommended vaccine strains, denoting sub-optimal vaccine efficacy. Additionally, data generated point to a swiftly evolving influenza A (H1N1) pdm09 virus in recent post pandemic era, underscoring the need for sustained surveillance coupled with molecular and antigenic analyses, to inform appropriate and timely influenza vaccine update.

Cheserek JJ, Ngugi K, Muthomi JW, Omondi CO. "Assessment of Arabusta coffee hybrids [Coffea arabica L. X Tetraploid Robusta (Coffea canephora )] for green bean physical properties and cup quality." African Journal of Food Science. 2020;14(5):119-127.
Joseph Muiruri, Wahome R, Karatu K. "Assessment of methods practiced in the disposal of solid waste in Eastleigh Nairobi County, Kenya [J]." AIMS Environmental Science. 2020;7(5):434-448.
Gichure M, Onono J, Wahome R, Gathura P. "Assessment of Phenotypic Characteristics and Work Suitability for Working Donkeys in the Central Highlands in Kenya." Veterinary Medicine International. 2020;2020.
Makori AO, Nyongesa AW, Odongo HO, Masai RJ. "Assessment of stress on serum estradiol and cortisol levels in female subordinate naked mole rats following isolation from natal colony." Journal of Biosciences and Medicines. 2020;8:9-17.
S.Senda T, Lance W. Robinson, K.K.Gachene C, Kironchi G, Doyo J. "An assessment of the implications of alternative scales of communal land tenure formalization in pastoral systems." Land use Policy. 2020;94.
Chebet EB, Kibet JK, Mbui D. "The assessment of water quality in river Molo water basin, Kenya." Applied Water Science. 2020;10(4):1-10. AbstractApplied Water Science

Description
The monitoring of water quality for both domestic and commercial use is absolutely essential for policy formulation that affects both public and environmental health. This study investigates the quality of water of river Molo system which lies in the Kenyan Rift Valley. The river is considered a vital source of water for the residents and industrial activities in Nakuru and Baringo Counties. Six water samples were collected during the dry season of December 2017. Various physicochemical parameters were determined in situ by use of a portable pH meter. These parameters included pH, temperature, electrical conductivity and total dissolved solids (TDS). Anions such as fluorides, sulfates, phosphates, nitrates, chlorides, carbonates and bicarbonates were determined using conventional methods such as titrimetry and (ultra-violet visible) UV–Vis techniques. The cations including sodium, potassium, calcium and …
Total citations
Cited by 1

Inyega J, Muchemi G. "Attitude towards undergraduate training in agriculture and veterinary sciences by secondary school students, teachers and parents in Kenya." Journal of Pedagogy, Andragogy and Heautagogy in Academic Practice. 2020;1(1):8-18.
GO O, EK G, S N. "Audit on the management of early rheumatoid arthritis in Nairobi." Afr J Rheumatol. 2020;8(1):22-25. Abstractaudit_on_the_management_of_early_rheumatoid_arthitis_in_nairobi.pdf

Background
: Clinical audit for rheumatoid arthritis on patients over
the age of 18 years in Nairobi, Kenya within the first three months of referral to a specialist. Objective: The audit gives detailed
information on the following; access to care, quality of treatment and
care received by patients from their rheumatology team in these first 3 months and the early impact of arthritis on the patient’s life.
Design: This was a cross-sectional
survey. Results
: The audit included 100 patients referred to the Nairobi Arthritis
Clinic between January and April 2018. A majority (54%) had symptoms for
more than 6 months before being referred to a rheumatologist. Most of
the patients (83%) were seen within 3 weeks of referral. Disease Modifiying
Antirheumatic Drugs (DMARDs) were commenced in 90% within 6 weeks of
being seen at the clinic. Treatment to target was done in 98% of the patients
with a further 60% able to access the clinic within a day of flare of symptoms. Conclusion: The audit revealed the
need to improve on referral time to the rheumatologist. It was encouraging
to note that once they saw the rheumatologists the patients were
commenced on the proper treatment with the treat to target strategy. An area
that needs improvement is the time to access the rheumatologist in case of
side effect from the treatment or flare of the disease

OdongoMahacla, BeboraLillyCaroline, KagunyaDavid, KarabaW, MbuthisPG. Bacteriology and Mycology Handbook for Veterinary students.. Mauritius: LAP Lambert Academic Publishing; 2020.
Orata D. Basic Statistical Thermodynamics. Germany: Lambert Academic Publishing; 2020. AbstractLap Lambert Academic Publishing

Basic Statistical Thermodynamics is a textbook suitable for senior undergraduate students and can be used also by posstgraduate students in Universities. This book is a culmination of over three decades of teaching at the University of Nairobi. The approach in the text is geared towards ensuring that, the student can use the book for self study. This has been achieved by showing in detail a step wise manner the derivation of the concepts and principles of statistical thermodynamics.

Jeneby F, Badrus A, Taib H, Alluso A, Odiemo L, Otanga H. "Best practices in reaching ‘hidden’ populations and harm reduction service provision.". In: The Impact of Global Drug Policy on Women: Shifting the Needle. New York: Emerald Publishing Company; 2020.
Mbugua JK, Mbui DN, Mwaniki JM, Mwaura FB. "Biochemical Methane Potential (BMP) of Market Wastes from Nairobi Inoculated With Dagoretti Slaughterhouse Waste." Int J Sci Res Sci Eng & Technol.. 2020;7(4):81-90. Abstract

Background: Anaerobic degradation entails the conversion of substrate organic matter to biogas. A wide variety of substrate has been employed. The biochemical methane potential of twenty market wastes was investigated using rumen fluid inoculum.
Experimental: The proximate properties like carbohydrates, crude proteins, crude lipids, fibre, and moisture levels were determined using standard procedures. The physio-chemical analysis was done to investigate the ash, total solids and volatile matter content. The substrates biogas production capacity
based on elemental composition, COD, organic fraction composition was investigated. However, the BMP experiments were carried out at mesophillic conditions.
Results: The total biogas production was in the range of 1000 to 3500ml, with a methane composition of 56 – 60%. The biodegradability of the substrates ranges from 71 to 94%, subject to the lignin levels.
Conclusion: The BMP studies are vital in assessing the methane potential of the substrate without carrying out the experiments.
Keywords : Biogas, Methane, rumen fluid, market wastes.

Kamau JM, Mbui DN, Mwaniki JM. Biogas Digester Automation.; 2020.
Twala PP, Mitema A, Baburam C, Feto, N.A. "Breakthroughs in the discovery and use of different peroxidase isoforms of microbial origin." AIMS Microbiology. 2020;6(3):330-349.
Bitange NM, Chemining’wa GN, Ambuko J, Owino W. "Can calcium sprays alleviate jelly seed in mango fruits?" Journal of Agriculture and Rural Development in the Tropics and Subtropics. 2020;Vol. 121 (1):35-42.abstract
Ogeng’o J, Ouko I, Wambui A, Amuti T. "A case Report on unusual elongation of the Sustentaculum tali." Anatomy Journal of Africa. 2020;9(1):1678-1680.
Achollah AM, Karanja DN, Ng’ang’a CJ, Bebora LC. "Causes of organ condemnations in cattle at slaughter and associated financial losses in Siaya County, Kenya." Journal of Veterinary Medicine and Animal Health. 2020;12:27-35.
Otieno SP, Cooke P, Plastow J. "Challenging the Message of the Medium: Scaling Participatory Arts Projects and the Creative Agenda in Kenya.". In: Participatory Arts in International Development . London: Routledge; 2020.
Mwangi, M.W. MKWM & JW. "Characterisation of Fusarium species infecting tomato in Mwea West Sub-county, Kirinyaga County, Kenya." Can. J. Plant Pathol. 2020;. https://doi.org/10.1080/07060661.2020.1788645.
Rop K, Mbui D, Karuku GN, Michira I, Njomo N. "Characterization of water hyacinth cellulose-g-poly (ammonium acrylate-co-acrylic acid)/nano-hydroxyapatite polymer hydrogel composite for potential agricultural application." Results in Chemistry. 2020;2:100020. AbstractResults in Chemistry

Description
Polymer nano-composite was prepared by grafting partially neutralized acrylic acid onto swollen cellulose isolated from water hyacinth in the presence of nano-hydroxyapatite (nano-HA) using N,N-methylene-bis-acrylamide (MBA) as the cross-linker and ammonium persulphate (APS) as the free radical initiator. Water absorption tests showed an increase in swelling ratio of the copolymer with increased nano-HA content to value of 120 g/g at 2.5% w/v above which it declined. FTIR spectrum of nano-composite revealed grafting of the monomer (acrylic acid/ammonium acrylate) onto cellulose and nano-HA. Transmission electron microscopy (TEM) images of nano-HA synthesized in the presence of Triton X-100 (non-ionic surfactant) displayed rod-shaped agglomerates and nano-particle dispersion within the copolymer matrix. Energy dispersive X-ray (EDX) spectra revealed the constituents of nano-composite to be …

Rop K, Mbui D, Karuku GN, Michira I, Njomo N. "Characterization of water hyacinth cellulose-g-poly (ammonium acrylate-co-acrylic acid)/nano-hydroxyapatite polymer hydrogel composite for potential agricultural application." Results in Chemistry. 2020;2:100020. AbstractResults in Chemistry

Description
Polymer nano-composite was prepared by grafting partially neutralized acrylic acid onto swollen cellulose isolated from water hyacinth in the presence of nano-hydroxyapatite (nano-HA) using N,N-methylene-bis-acrylamide (MBA) as the cross-linker and ammonium persulphate (APS) as the free radical initiator. Water absorption tests showed an increase in swelling ratio of the copolymer with increased nano-HA content to value of 120 g/g at 2.5% w/v above which it declined. FTIR spectrum of nano-composite revealed grafting of the monomer (acrylic acid/ammonium acrylate) onto cellulose and nano-HA. Transmission electron microscopy (TEM) images of nano-HA synthesized in the presence of Triton X-100 (non-ionic surfactant) displayed rod-shaped agglomerates and nano-particle dispersion within the copolymer matrix. Energy dispersive X-ray (EDX) spectra revealed the constituents of nano-composite to be …

Rop K, Mbui D, Karuku GN, Michira I, Njomo N. "Characterization of water hyacinth cellulose-g-poly (ammonium acrylate-co-acrylic acid)/nano-hydroxyapatite polymer hydrogel composite for potential agricultural application." Results in Chemistry. 2020;2:100020. AbstractResults in Chemistry

Description
Polymer nano-composite was prepared by grafting partially neutralized acrylic acid onto swollen cellulose isolated from water hyacinth in the presence of nano-hydroxyapatite (nano-HA) using N,N-methylene-bis-acrylamide (MBA) as the cross-linker and ammonium persulphate (APS) as the free radical initiator. Water absorption tests showed an increase in swelling ratio of the copolymer with increased nano-HA content to value of 120 g/g at 2.5% w/v above which it declined. FTIR spectrum of nano-composite revealed grafting of the monomer (acrylic acid/ammonium acrylate) onto cellulose and nano-HA. Transmission electron microscopy (TEM) images of nano-HA synthesized in the presence of Triton X-100 (non-ionic surfactant) displayed rod-shaped agglomerates and nano-particle dispersion within the copolymer matrix. Energy dispersive X-ray (EDX) spectra revealed the constituents of nano-composite to be …

Rop K, Mbui D, Karuku GN, Michira I, Njomo N. "Characterization of water hyacinth cellulose-g-poly (ammonium acrylate-co-acrylic acid)/nano-hydroxyapatite polymer hydrogel composite for potential agricultural application." Results in Chemistry. 2020;2:100020. AbstractResults in Chemistry

Description
Polymer nano-composite was prepared by grafting partially neutralized acrylic acid onto swollen cellulose isolated from water hyacinth in the presence of nano-hydroxyapatite (nano-HA) using N,N-methylene-bis-acrylamide (MBA) as the cross-linker and ammonium persulphate (APS) as the free radical initiator. Water absorption tests showed an increase in swelling ratio of the copolymer with increased nano-HA content to value of 120 g/g at 2.5% w/v above which it declined. FTIR spectrum of nano-composite revealed grafting of the monomer (acrylic acid/ammonium acrylate) onto cellulose and nano-HA. Transmission electron microscopy (TEM) images of nano-HA synthesized in the presence of Triton X-100 (non-ionic surfactant) displayed rod-shaped agglomerates and nano-particle dispersion within the copolymer matrix. Energy dispersive X-ray (EDX) spectra revealed the constituents of nano-composite to be …

Munene JM, Onyatta JO, Yusuf AO. "Characterization of Water Hyacinth Powder Using FTIR Spectroscopy and the Adsorption Behaviour of Pb2+, Cd2+, Zn2+, Ni2+ and Cr2+ in Aqueous Solution ." Asian Journal of Applied Chemistry Research. 2020;6(1):47-55. AbstractAsian Journal of Applied Chemistry Research

Description
The adsorption behavior of selected metal ions on water hyacinth powder was investigated by Fourier Transform Infrared (FTIR) spectroscopy. Water hyacinth powder was used as an adsorbent due to its popularity, low cost and ease of availability. Water hyacinth stems were dried and ground to a powder. Batch adsorption experiments were conducted at room temperature by adding known concentrations of Pb 2+, Cd 2+, Cr 3+, Zn 2+ and Ni 2+ to 5 g of water hyacinth powder in different test tubes and allowed to stand for the same time respectively. Adsorption is one of the methods used to remove heavy metals from aqueous solutions and wastewaters. FTIR analysis was performed to identify the functional groups in the water hyacinth powder using the KBr disc method. The study showed a strong broad absorption band in the region of 3300-3200cm-1 which is characteristic of OH stretching vibrations of the adsorbed water molecules at the surface of raw water hyacinth powder particles. Other peaks appeared at 1732cm-1 which corresponded to C= O stretching vibrations while the band at 1396cm-1 could be attributed to CH bonds. The functional groups identified were: CH; OH; C= O or CO. After adsorption there was a disappearance, reduction or a shift in the adsorption bands depending on the type of metal ion. Lead for example showed a strong absorption band in the region of 1732cm-1 which is characteristic of C= O stretching bond structure which is found in esters and carboxylic acids. The disappearance of the peaks indicated that the H atom present in the functional groups of the raw water hyacinth powder could have been substituted …

Chalo DM, Kakudidi E, Origa-Oryem H, Namukobe J, Franke K, Yenesew A, Wessjohann LA. "Chemical constituents of the roots of Ormocarpum sennoides subsp. zanzibaricum." Biochemical Systematics and Ecology. 2020;93:104142. AbstractBiochemical Systematics and Ecology

Description
Phytochemical investigation of the roots of O. sennoides subsp. zanzibaricum Brenan & J.B. Gillett resulted in the isolation of three biflavonoids (trime-chamaejasmin, (+)- chamaejasmin, (+)-liquiritigeninyl-(I-3,II-3)-naringenin), one bi-4-phenyldihydrocoumarin (diphysin), one isoflavan (glabridin), one triterpenoid (3-O-acetyloleanoic acid) and a phytosterol (β-sitosterol). Compounds were identified by detailed MS, 1D and 2D NMR spectroscopic analyses. Their absolute configurations were elucidated based on ECD spectra. The previously undescribed trime-chamaejasmin represents a bis-epi-chamaejasmenin C diastereomer. The chemophenetic significance is discussed in detail. The results contribute to the phytochemical characterization of the genus Ormocarpum and suggest a close chemophenetic relationship with other genera within the subfamily Papilionoideae. Furthermore, this report provides baseline …

Jane Ireri, Pokhariyal G, Moindi S. "Chemostat Model with Periodic Nutrient Input Described by Fourier Series." Asian Research Journal of Mathematics. 2020;16(8):16-27. AbstractWebsite

In this paper we present a periodic Chemostat model of two species competing for a single nutrient available in limiting supply. The nutrient input is varied periodically using a Fourier series function to take into account the changing patterns as seasons vary. We show both analytically and numerically that varying the nutrient input using a Fourier Series function results in a better model to describe coexistence of species in natural environments.

Nyamweya NN, Kimani SN, Abuga KO. "Chewable Antacid Tablets: Are Disintegration Tests Relevant?" AAPS PharmSciTech . 2020;21:139. Abstract

A recently published FDA guidance on chewable tablets has addressed the quality attributes of this class of dosage forms. This study evaluated disintegration as a quality attribute for a number of commercially available chewable antacid tablets. Additionally, acid-neutralizing-capacity values were evaluated. A number of the products exhibited prolonged disintegration times—which were far longer than those of conventional immediate-release tablets. The mean disintegration times ranged from 6 to more than 60 min in distilled water and from 9 to over 60 min in 0.1 N HCl. The products with longer disintegration times had higher breaking force and tensile strength values. Despite the range in disintegration times, all products met the criteria for acid-neutralizing capacity. These results indicate a need for patients to be aware of the need to thoroughly chew antacid tablets upon administration. Given these considerations, disintegration testing would be a useful quality control test in evaluating these dosage forms as the implicit assumption by the manufacturer that patients will chew the product sufficiently may not be met in every case.

Owino JO, Olago D, Wandiga SO, Ndambi A. "A cluster analysis of variables essential for climate change adaptation of smallholder dairy farmers of Nandi County, Kenya." African Journal of Agricultural Research. 2020;16(7):1007-1014. AbstractA cluster analysis of variables essential for climate change adaptation of smallholder dairy farmers of Nandi County, Kenyadoi.org

Smallholder dairy farmers occupy high potential areas of Kenya and are a source of manure, crops and milk. There is need to use other means of characterising smallholder dairy farmers as they mostly practice mixed farming. The objective of this paper is to use cluster analysis method to characterize the smallholder dairy farmers with added farmer and activity data variables. Clusters of 336 farmers in this study were derived using 28 key variables. This paper demonstrates how to conduct farmer assessments for climate change adaptation activities, climate smart technologies implementation using knowledge of key farmer variables and their distribution in the smallholder dairy farmers of Nandi County, Kenya. This paper demonstrates the importance of integrating agricultural information for smallholder dairy farmers to machine models to characterize the groups and observe the natural groupings. This allows for policy managers to know the key characteristics and how to use them in policy implementation especially in designing climate change adaptation programs factoring education and training of farmers as demonstrated in this paper that they are practicing many activities on their farms.

Key words: Cluster analysis, smallholder dairy farmers, farm utilisation, climate change adaptation.

KURIA JOSEPHNGEIK, MOGOI DONALD, GACHUHI SAMUELGUCHU. "Co-infection by dimorphic fungi in tuberculosis patients in Kenya." International Journal of Mycobacteriology. 2020;9:116-120.
Shem Otoi Sam, Manene MM, Isaac C Kipchirchir, Pokhariyal GP. "Cointegration analysis of youth unemployment in Kenya." International Journal of Statistics and Applied Mathematics. 2020;5(3):129-133. AbstractWebsite

In this paper analysis of contribution of macroeconomic variables gross domestic product (GDP), external debt (ED), foreign direct investment (FDI), private investment (PI), youth population (POP), and youth literacy rate (LR) to youth unemployment(YUN) in Kenya over time is done. The analysis is done under framework of cointegration of time series data. First, logarithmic transformation of the series is carried out followed by stationarity test to determine the order of stationarity. The Philip-Ouliaris cointegration test is carried out to determine whether the series are individually cointegrated in a pair-wise manner. Then the Johansen cointegration test is conducted to determine the rank of cointegration. The paper does not proceed to identify cointegration relations as that is superfluous as far as estimation of linear cointegration model is concerned. Finally the linear cointegration equation of the macroeconomic variables is estimated and interpreted. Philip-Ouliaris test reveals that six pairs are I(0) while 15 pairs are I(1). The Augmented Dickey-Fuller test finds that GDP, FDI, and ED are stationary at level, i.e. without differencing whereas PI, LR, YUN, and POP are stationary of first difference. According to Johansen cointegration test, the rank of cointegration is 3, revealing three cointegration relations among the variables used. The results indicate that 1% increase in GDP, ED, FDI, and LR increases YUN by 0.356204%, 0.269%, 0.002441%, and 0.154216 respectively. Contrarily, 1% increasein population reduces youth unemployment by 0.350833%.The model is subjected to F-test and p-value test and found to be statistically significant

Shem Otoi Sam, Manene MM, Isaac C Kipchirchir, Pokhariyal GP. "Cointegration analysis of youth unemployment in Kenya." International Journal of Statistics and Applied Mathematics. 2020;5(3): 129-133. AbstractWebsite

In this paper analysis of contribution of macroeconomic variables gross domestic product
(GDP), external debt (ED), foreign direct investment (FDI), private investment (PI), youth
population (POP), and youth literacy rate (LR) to youth unemployment (YUN) in Kenya over
time is done. The analysis is done under framework of cointegration of time series data. First,
logarithmic transformation of the series is carried out followed by stationarity test to determine
the order of stationarity. The Philip-Ouliaris cointegration test is carried out to determine
whether the series are individually cointegrated in a pair-wise manner. Then the Johansen
cointegration test is conducted to determine the rank of cointegration. The paper does not
proceed to identify cointegration relations as that is superfluous as far as estimation of linear
cointegration model is concerned. Finally the linear cointegration equation of the
macroeconomic variables is estimated and interpreted. Philip-Ouliaris test reveals that six pairs
are I(0) while 15 pairs are I(1). The Augmented Dickey-Fuller test finds that GDP, FDI, and
ED are stationary at level, i.e. without differencing whereas PI, LR, YUN, and POP are
stationary of first difference. According to Johansen cointegration test, the rank of
cointegration is 3, revealing three cointegration relations among the variables used. The results
indicate that 1% increase in GDP, ED, FDI, and LR increases YUN by 0.356204%, 0.269%,
0.002441%, and 0.154216 respectively. Contrarily, 1% increase in population reduces youth
unemployment by 0.350833%.The model is subjected to F-test and p-value test and found to
be statistically significant.

Ongeri BO, Mutasa F. "Commercial banks’ performance and economic growth nexus: -An Empirical Analysis of Kenya’s Commercial Banks." International journal of scientific research and innovative technology . 2020;7(3):2313-3759.
Hassanali J., Pokhariyal G, P. M. "Comparative analysis of selected linear measurements of human and baboon brains." European Journal of anatomy. 2020;11 ((1)):9-16 . AbstractWebsite

The morphometric parameters of the brains of several mammals and primates show differences that are likely to be associated with cognitive and other functions necessary for survival as well as evolution. Seven human and eight baboon formalin-fixed brains were used to show comparative aspects. The whole brains were weighed, 3 from humans and 3 from baboons were separated into components -cerebrum, cerebellum and brainstem- and their weights were recorded. The linear measurements of the cerebrum were occipito-frontal (O-F), fronto-temporal (F-T) temporo-occipital (T-O), height of temporal lobe (HTL), inter: frontal pole (F-F), occipital pole (O-O), parietal (P-P), temporal pole (T-T), and occipital lobe (OL-OL) from superior, lateral and inferior aspects. The proportions of brain weight relative to body weight and those of the brain components were mostly higher in the humans. The length, height and width of the human brains were higher than in the baboons. F-F was six times O-O in humans while other parameters were nearly double in humans as compared to baboons. The ratio of P-P to F-F was nearly 20 times in baboons as compared to 6 times in humans. The overall increase in human brain length, width and size of lobes could be related to increased body size, functional complexity, upright posture, and evolution. The lateral expansion in the size of the frontal, temporal and occipital lobes may be due to the complex circuitry associated with cognitive functions and life style. Several approaches have been proposed to determine factors related to increases in brain size, function and intelligence. Morphometry could be one tool to "explain" specific increases in brain areas.

Kibegwa FM, Bett RC, GACHUIRI CHARLESK, Francesca Stomeo, Mujibi FD. "A Comparison of Two DNA Metagenomic Bioinformatic Pipelines while evaluating the Microbial Diversity in feces of Tanzanian small holder dairy cattle." BioMed research international. 2020;2020.
Kibegwa FM, Bett RC, GACHUIRI CHARLESK, Francesca Stomeo, Mujibi FD. "A Comparison of Two DNA Metagenomic Bioinformatic Pipelines while evaluating the Microbial Diversity in feces of Tanzanian small holder dairy cattle." BioMed research international. 2020;2020.
Richard N. Onwonga, Ruth C. Sitienei, Joyce J. Lelei, Kamoni P. "Complementary Effects of Legume Integration and Fertilizer application on Soil Moisture and Long-Term Carbon Stocks in Maize Systems of Kabete Sub-County, Kenya." Tropical and Subtropical Agroecosystems. 2020.
Gawriluk TR, Simkin J, Hacker CK, Kimani JM, Kiama SG, Ezenwa VO, Seifert AW. "Complex Tissue Regeneration in Mammals Is Associated With Reduced Inflammatory Cytokines and an Influx of T Cells." Front. Immunol.. 2020;11(1695):1-19.
Akinyemi R, Sarfo F, Abd-Allah F, Ogun Y, Ogeng'o J. "Conceptual framework for establishing the African Stroke Organization .". 2020. AbstractWebsite

Abstract

Africa is the world's most genetically diverse, second largest, and second most populous continent, with over one billion people distributed across 54 countries. With a 23% lifetime risk of stroke, Africa has some of the highest rates of stroke worldwide and many occur in the prime of life with huge economic losses and grave implications for the individual, family, and the society in terms of mental capital, productivity, and socioeconomic progress. Tackling the escalating burden of stroke in Africa requires prioritized, multipronged, and inter-sectoral strategies tailored to the unique African epidemiological, cultural, socioeconomic, and lifestyle landscape. The African Stroke Organization (ASO) is a new pan-African coalition that brings together stroke researchers, clinicians, and other health-care professionals with participation of national and regional stroke societies and stroke support organizations. With a vision to reduce the rapidly increasing burden of stroke in Africa, the ASO has a four-pronged focus on (1) research, (2) capacity building, (3) development of stroke services, and (4) collaboration with all stakeholders. This will be delivered through advocacy, awareness, and empowerment initiatives to bring about people-focused changes in policy, clinical practice, and public education. In the spirit of the African philosophy of Ubuntu "I am because we are," the ASO will harness the power of diversity, inclusiveness, togetherness, and team work to build a strong, enduring, and impactful platform for tackling stroke in Africa.

Owino JO, Olago D, Wandiga SO, Ndambi A. "Constraints limiting the improvement of manure management as climate smart technology for smallholder dairy farmers." African Journal of Agricultural Research. 2020;16(8):1155-1168. Abstractacademicjournals.org

The global quest for a sustainable bio-economy has brought to the fore importance of engaging agricultural systems in the production and in practice change. There have been issues limiting farmers from improving the practice of manure management as smart climate technology. The objective of this paper was to highlight the constraints, type, and valuation of manure types and information sources that smallholder dairy farmers find it useful to change Practices regarding manure management. In this present study, 336 smallholder dairy farmers were surveyed on various constraints the farmers faced and, on the type, and value of different manure types and information on manure management received by the farmers. The study used descriptive statistics for the variables and compared them using frequency tables. The key findings from this study would support information to stakeholders in inducing climate-smart manure management practices as a climate adaptation practice. The study highlights the type of information systems that determine areas for further investigation as drivers of practice change for smallholder dairy farmers. The paper focuses on these constraints and synthesizes them into factors that determine practice change on manure management by smallholder dairy farmers in order to improve manure management.

Key words: Manure management, agricultural information, smallholder dairy farmers, practice change,
information value.

Ntwiga DB, Wanyonyi AW. "Consumer Perceptions and Behaviour toward Credit Usage in Kenya." Open Access Library Journal. 2020;7(6):1-16. AbstractWebsite

Consumer behaviour and perceptions evolve over time and affect credit usage from the financial service providers. We use the 2016 FinAccess Household survey data of 2015 from 8665 households to examine how perceptions and behaviour of un(der) banked consumers can shape their dynamics towards credit usage. The perceptions and behaviour are based on source of financial advice, trust of the institutions, characteristics of the financial instrument and cost of credit. The multinomial logistic regression model predicts the odds of credit usage based on perceptions and behaviour of the consumers. The categories for the credit usage are: have credit, used to have credit and never had credit. Consumer perceptions and behaviour based on cost of credit and trust increase credit usage, while source of financial advice had minimal influence on credit usage. The characteristics of the financial instrument are catering to emergencies and being safe to use increased credit usage. The Savings and Credit Cooperative Organizations and microfinance are the most trusted financial institutions by the consumers, while shylock has the highest cost of credit. Radio as a source of financial advice reduced credit usage. The dynamics of credit usage are shaped by the perceptions and behaviour of the consumers.

Ntwiga DB. "Credit usage among the un (der) banked: consumer socio-economic characteristics and influence of financial technology." International Journal of Financial Services Management. 2020;10(1):38-54. AbstractWebsite

We use the 2016 FinAccess Household survey data of 2015 from 8665 households to analyse how the socio-economic characteristics and financial literacy of un(der) banked consumers can shape their dynamics towards credit usage. A qualitative analysis is presented on the influence of financial technology on consumer credit usage. The access to financial services is influenced by the socio-economic characteristics and financial literacy of the consumers. Gender, financial literacy, age, income, marital status, education level and geographical cluster are statistically significant in influencing credit usage, both current and past usage relative to never had credit. As financial technology continues to expand and offer credit, there is need to understand the user experience to match their social and economic status as a means to increase credit usage in Kenya.

Oluoch JO, Rambo CM, Pokhariyal GP. "Data Dissemination and Use and Provision of Curative and Preventive Tuberculosis Health Care Services in Public Health Institutions in Kisumu County, Kenya ." European Journal of Business and Management Research. 2020;5((1)). Abstractview

The study sought to determine how data dissemination and use influence provision of curative and preventive tuberculosis healthcare in institutions of public health in Kisumu County, Kenya. The study focused on public health institutions that practices M&E system on provision of curative and preventive tuberculosis healthcare services. The study employed the use of pragmatism paradigm and a descriptive research design to collect both quantitative and qualitative data. A correlational design was used to test the hypothesis. A sample of 221 respondents was selected from a population of 517 using stratified random sampling. Data was collected using a structured questionnaire with both open and close ended with Likert type on 1-5 five point scale and interview schedule. Correlational design was used to test the hypothesis. Quantitative data was analyzed using descriptive and inferential statistics and data presented in frequency tables using means and standard deviations while qualitative data was presented in in narrative statements. Hypothesis was tested using linear regression at 0.05 level of significance to determine the degree and direction of relationships among the thematic area of the study. The reliability of the instruments was obtained using Cronbach Alpha coefficient of 0.735 for all items meaning that the instruments were reliable. The results showed that data dissemination and use and provision of curative and preventive tuberculosis health care services in public health institutions had [r2=0.186, p<0.05]. The results for quantitative data based on composite mean score of 3.91 and 0.466 standard deviation for this variable respectively. Therefore, data dissemination and use influence provision of curative and preventive tuberculosis healthcare services in public health institutions.

Oluoch JO, Rambo CM, Pokhariyal GP. "Data Dissemination and Use and Provision of Curative and Preventive Tuberculosis Health Care Services in Public Health Institutions in Kisumu County, Kenya." European Journal of Business and Management Research. 2020;5(1). AbstractWebsite

The study sought to determine how data dissemination and use influence provision of curative and preventive tuberculosis healthcare in institutions of public health in Kisumu County, Kenya. The study focused on public health institutions that practices M&E system on provision of curative and preventive tuberculosis healthcare services. The study employed the use of pragmatism paradigm and a descriptive research design to collect both quantitative and qualitative data. A correlational design was used to test the hypothesis. A sample of 221 respondents was selected from a population of 517 using stratified random sampling. Data was collected using a structured questionnaire with both open and close ended with Likert type on 1-5 five point scale and interview schedule. Correlational design was used to test the hypothesis. Quantitative data was analyzed using descriptive and inferential statistics and data presented in frequency tables using means and standard deviations while qualitative data was presented in in narrative statements. Hypothesis was tested using linear regression at 0.05 level of significance to determine the degree and direction of relationships among the thematic area of the study. The reliability of the instruments was obtained using Cronbach Alpha coefficient of 0.735 for all items meaning that the instruments were reliable. The results showed that data dissemination and use and provision of curative and preventive tuberculosis health care services in public health institutions had [r2=0.186, p<0.05]. The results for quantitative data based on composite mean score of 3.91 and 0.466 standard deviation for this variable respectively. Therefore, data dissemination and use influence provision of curative and preventive tuberculosis healthcare services in public health institutions.

Howell KL, Hilário A, Allcock LA, et al. "A decade to study deep-sea life." Nature Ecology & Evolution . 2020;5:265-267.
Nicholas M. Jacob, Shem O. Wandiga DKVMKO. "Degradation of Aflatoxin in Maize using Ferulic Acid (Phydroxy-3-Methyl Cinnamic Acid) Catalyzed by Hydrogen Peroxide." International Journal of Food Science . 2020;3(1):1-17.
Mwenda JN, Wandiga SO, Kariuki DK, Madadi VO. "Degradation of aflatoxin in maize using Ferulic acid (phydroxy-3-methyl cinnamic acid) catalyzed by Hydrogen peroxide." Journal of Food Sciences. 2020;1(1):1-17.
Jane Ireri, Pokhariyal G, Moindi S. "Delayed Nutrient Conversion for a Single Species Periodic Chemostat." Journal of Scientific Research and Reports. 2020;26(5):1-9. AbstractWebsite

In this paper we analyze a Chemostat model with periodic nutrient input modelled using Fourier series and incorporate delays in nutrient conversion. We show that both periodicity and delays have complementing influence in the long term behaviour of the species. Numerical results show that periodicity has bigger influence on species density variations for delays below the Hopf Bifurcation point, while for delays above the Bifurcation point,the delay effect is more influential.

S D, GO O, V O-H. "Depression and its association with disease activity and quality of life in patients with rheumatoid arthritis at the Kenyatta National Ho." Afr J Rheumatol. 2020;8(1):15-21. Abstractdepression_and_its_association_with_disease_activity.pdf

Background: Rheumatoid arthritis
is a systemic inflammatory disease that affects the synovial membrane,
resulting in the structural damage of cartilage, bone and ligaments. The
course of RA differs between patients, and its severity can range from selflimiting
disease to severe destruction and systemic complications. RA affects
patients physically, psychologically and socially. Patients experience pain,
joint swelling, stiffness, functional limitations and fatigue and overall poor
quality of life. In addition, they report anxiety and depressive symptoms
and concerns about increased physical limitations. Experiencing
psychological distress may inflate the subjective severity of patient-reported
symptoms such as pain and tenderness. Furthermore, patients experience a
loss of independence and restrictions in participation, i.e. a decrease in
socializing which may in turn propagate symptoms of depression. An accurate
description of the relationship between depression, disease severity and quality
of life is necessary for our setting. If an interaction exists, then there is a
group of vulnerable patients who could benefit from earlier identification
of depression and the impact their disease has on HRQoL and appropriate
management provided. Objective: To determine the prevalence
of depression and the relationship between depression, disease activity
and quality of life in ambulatory patients with rheumatoid arthritis at
the Kenyatta National Hospital.Design: A descriptive-cross sectional

Ndungu JM, Moturi CA. "Determinants of Mobile Fintech Uptake in Kenyan Microfinance Sector." Current Journal of Applied Science and Technology. 2020;39(28):102-114. AbstractWebsite

The Kenyan microfinance sector faces many challenges such as high operation costs, increased credit risk, low visibility and poor understanding of emerging technology opportunities and risks among others. These problems are persistent due to low levels of innovation and limited uptake of digital financial technologies. This research aimed to identify the determinants that influence uptake of mobile fintech and propose an appropriate model for uptake of mobile fintech within the sector. A descriptive survey of all 30 Microfinance institutions registered with Association of Microfinance Institutions (AMFI) 2018 in Kenya was carried out. Data was collected using questionnaires from 120 respondents. Data was analyzed using descriptive and inferential statistics. Based on correlation model, this study established that technology factors (r=0.862, P<.05), environmental characteristics (r=0.387, P<.05) and organizational factors (r=0.256, P<.05) have a strong influence on the uptake of mobile fintech. Using regression model, technology factors (β=.563, P<.05), organizational factors (β=.281, P<.05) and environmental characteristics (β=.562, P<.05) all have positive and significant influence on uptake of mobile fintech. These factors include technology availability, perceived technology benefits, organization size, resources availability, and competition, regulatory and legal environment among others. Uptake of mobile fintech was found to reduce operation costs and improve business operations efficiency. Understanding of the factors derived in this study will help microfinance institutions, software developers and policy makers as they develop strategies directed at promoting successful implementation of mobile fintech.

Sala, M.S., Otieno JD, Nzuma, M.J., Mureithi, S.M. "Determinants of Pastoralists’ Participation in Commercial Fodder Markets for Livelihood Resilience in Drylands of Northern Kenya: Case of Isiolo." Pastoralism: Research, Policy and Practice . 2020;10(1):DOI: 10.1186/s13570-020-00166-1.
Chirwa TF, Zingoni ZM, Munyewende P, Manda SO, Mwambi H, Kandala N-B, Kinyanjui S, Young T, Musenge E, Simbeye J, Musonda P, Mahande MJ, Weke P, Onyango NO, Kazembe L. "Developing excellence in biostatistics leadership, training and science in Africa: How the Sub-Saharan Africa Consortium for Advanced Biostatistics (SSACAB) training unites …." AAS Open Research. 2020;3(51). AbstractWebsite

The increase in health research in sub-Saharan Africa (SSA) has led to a high demand for biostatisticians to develop study designs, contribute and apply statistical methods in data analyses. Initiatives exist to address the dearth in statistical capacity and lack of local biostatisticians in SSA health projects. The Sub-Saharan African Consortium for Advanced Biostatistics (SSACAB) led by African institutions was initiated to improve biostatistical capacity according to the needs identified by African institutions, through collaborative masters and doctoral training in biostatistics. SACCAB has created a critical mass of biostatisticians and a network of institutions over the last five years and has strengthened biostatistics resources and capacity for health research studies in SSA. SSACAB comprises 11 universities and four research institutions which are supported by four European universities. In 2015, only four universities …

Murage JK, Amugune BK, Njogu P, Ndwigah SN. "Development and application of a spectrophotometric method in quality evaluation of benzimidazole anthelminthics in Nairobi City County." Future Journal of Pharmaceutical Sciences . 2020;6:74.
Murage JK, Amugune BK, Njogu PM, S.N.Ndwigah. "Development and application of aspectrophotometric method in qualityevaluation of benzimidazole anthelminthicsin Nairobi city county." Future Journal of Pharmaceutical Sciences . 2020;6:74.
Mitema A, Feto NA, Rafudeen MS. "Development and Validation of TOF/Q-TOF MS/MS, HPLC Method and in-vitro Bio-Strategy for Aflatoxin Mitigation." Food Additives & Contaminants. 2020.
Sola L, Levin NW, Johnson DW, Pecoits-Filho R, Aljubori HM, Chen Y, Claus S, Collins A, Cullis B, Feehally J, Harden PN, Hassan MH, Ibhais F, Kalantar-Zadeh K, Levin A, Saleh A, Schneditz D, Tchokhonelidze I, Kazancioglu RT, Twahir A, Walker R, Were AJO, Yu X, Finkelstein FO. "Development of a framework for minimum and optimal safety and quality standards for hemodialysis and peritoneal dialysis." Kidney International Supplements. 2020.
U B, M M, J M, Mwang’ombe, S G. "Disease surveillance and farmers’ knowledge of Brachiaria (Syn. Urochloa) grass diseases in Rwanda." African Journal of Range & Forage Science. 2020;. https://doi.org/10.2989/10220119.2020.1810774.
Uzayisenga B, Mutimura M, Muthom JW, Mwang’ombe AW, Ghimire SR. "Disease surveillance and farmers’ knowledge of Brachiaria (Syn. Urochloa) grass diseases in Rwanda." AFRICAN JOURNAL OF RANGE & FORAGE SCIENCE. 2020;tarf20:1-13.
Langat MK, Ndunda B, Salter C, Odusina BO, Isyaka SM, Mas-Claret E, Onocha PA, Midiwo JO, Nuzillard J-M, Mulholland DA. "Diterpenoids from the stem bark of Croton megalocarpoides Friis & M. G. Gilbert." Phytochemistry Letters. 2020;39:1-7.
Langat MK, Ndunda BM, Salter C, Odusina BO, Isyaka SM, Mas-Claret E, Onocha PA, Midiwo JO, Nuzillard J-M, Mulholland DA. "Diterpenoids from the stem bark of Croton megalocarpoides Friis & MG Gilbert." Phytochemistry Letters. 2020;39:1-7. AbstractPhytochemistry Letters

Description
Five previously undescribed compounds, megalocarpoidolide I (1), megalocarpoidolide J (3), 12-epi-crotonzambefuran A (4), megalocarpoidolide K (5), 1-trans-p-hydroxycoumaroyl–geranylgerani-1-ol (6) were isolated from the stem bark of Croton megalocarpoides Friis & M. G. Gilbert. The known ent-trachyloban-18-ol, megalocarpoidolide B, megalocarpoidolide C (2), megalocarpoidolide H, crotocorylifuran, 7,8-dehydrocrotocorylifuran, 1,2-dehydrocrotocorylifuran-2-one, acetyl aleuritolic acid, lupeol, N-trans-p-coumaroyl-3′,4′-dihydroxyphenylethylamine, dodecyl trans-ferulate and lignoceryl trans-ferulate were also isolated. The structures of the compounds were determined using NMR, IR spectroscopy and HRMS. The structure of compound 1 was determined using Logic for Structural Determination (LSD). Compounds 1, 2 and 3 that were selected for screening based on their ability to add diversity to the …

Mbithi ML. "Does COMESA Have Export Potential to Emerging Economies?" Journal of Economics and Sustainable Development. 2020;11(10):58-65.
Shah P. "Domestication of the Ramsar Convention in Kenya." Towards realizing of Vision 2030: Kenya Policy Briefs. Office of the DVC Research, Innovation and Extension. University of Nairobi. . 2020;1(1):13-14.
Alulu J, Otieno DJ, Oluoch-Kosura W, Ochieng J. "Drivers of transformations in smallholder indigenous vegetable value chains in western Kenya: Evolution of contract farming." Journal of Business and Economics. 2020;22(6):151-165.
Brizuela V, Bonet M, Romero CLT, Abalos E, Baguiya A, Fawole B, Knight M, Lumbiganon P, Minkauskienė M, Nabhan A, Osman NB, Qureshi ZP, Souza JP. "Early evaluation of the ‘STOP SEPSIS!’ WHO Global Maternal Sepsis Awareness Campaign implemented for healthcare providers in 46 low, middle and high-income countries." British Medical Journal . 2020;10(5). AbstractWebsite

Objective To evaluate changes in awareness of maternal sepsis among healthcare providers resulting from the WHO Global Maternal Sepsis Study (GLOSS) awareness campaign.

Design Independent sample precampaign/postcampaign through online and paper-based surveys available for over 30 days before campaign roll-out (pre) and after study data collection (post). Descriptive statistics were used for campaign recognition and exposure, and odds ratio (OR) and percentage change were calculated for differences in awareness, adjusting for confounders using multivariate logistic regression.

Setting and participants Healthcare providers from 398 participating facilities in 46 low, middle and high-income countries.

Intervention An awareness campaign to accompany GLOSS launched 3 weeks prior to data collection and lasting the entire study period (28 November 2017 to 15 January 2018) and beyond.

Main outcome measures Campaign recognition and exposure, and changes in awareness.

Results A total of 2188 surveys were analysed: 1155 at baseline and 1033 at postcampaign. Most survey respondents found the campaign materials helpful (94%), that they helped increase awareness (90%) and that they helped motivate to act differently (88%). There were significant changes with regard to: not having heard of maternal sepsis (−63.4% change, pre-OR/post-OR 0.35, 95% CI 0.18 to 0.68) and perception of confidence in making the right decisions with regard to maternal sepsis identification and management (7.3% change, pre-OR/post-OR 1.44, 95% CI 1.01 to 2.06).

Conclusions Awareness raising campaigns can contribute to an increase in having heard of maternal sepsis and an increase in provider perception of confidence in making correct decisions. Offering the information to make accurate and timely decisions while promoting environments that enable self-confidence and support could improve maternal sepsis identification and management.

Alphayo I. Lutta, Lance W. Robinson, Oliver V. Wasonga, Ruto E, Jason Sircely, Nyangito MM. "Economic valuation of grazing management practices: discrete choice modeling in pastoral systems of Kenya." Environmental Planning and Management. 2020;63(2).
and Caroline K. Kariuki EMWMWM. "Effect of Bacillus and Trichoderma species in the management of the bacterial wilt of tomato (Lycopersicum esculentum) in the field." Egyptian Journal of Biological Pest Control. 2020;30(109):doi.org/10.1186/s41938-020-00310-4 .
S W, A K, S K, I M. "Effect of Combining Clinical Teaching Tools on Clinical Judgment Skills of Undergraduate Nursing Students in Kenya." South Asian Research Journal of Nursing and Healthcare . 2020;2(1):117-123.
Mutuma Kiambi, B, Onono, P, Maingi, N. "Effect of Crude Oil Prices on Economic Growth in Kenya in the Period 1981 To 2018." Advances in Social Sciences Research Journal. 2020;7(10):340-349.
A.M H, Ongeri BO. "Effect of Islamic banking development on economic growth –A case of the Kenyan Economy." International Journal of Scientific Research and Innovative Technology . 2020;7(2).
Busienei J, Irungu P, Gichungi H, Muriithi B, Diiro G. "Effect of Technological Innovation on Gender Roles: The Case of Fruit Fly IPM Adoption on Women’s Decision‑Making in Mango Production and Marketing in Kenya." The European Journal of Development Research. 2020;10.1057(s41287-020-00282-z).
Mudavadi Patrick Ongadi, Emmanuel A Mpolya, Charles Gachuiri, Francis Namasake Muyekho, Lukuyu AB. "Effects of Season Variation on Water, Feed, Milk Yield and Reproductive Performance of Dairy Cows in Smallholder Farms in Eastern Africa." Journal of Agriculture and Ecology Research International. 2020.
OTHOO, Dulo, Olago, D. O., Ayah. "Effects of Shallow Water Table on the Construction of Pit Latrines and Shallow Wells in the Informal Settlements of Kisumu City." Sanitation Value Chain, J-STAGE an electronic journal platform for science and technology. 2020;5(1).
Maina J, Wandiga S, Gyampoh B, Gachene C. "Effects of Supplemental Irrigation on Crop Yields: Case Study Kales (Brassica Oleracea) Crop." Journal of Ecological Engineering. 2020;(21):209-213. AbstractEcological Engineering

The aim of this study was to investigate the effects that supplemental irrigation (SI) has on Kale (Brassica Oleracea) crop yields as compared to wholly rain-fed crop. The experiments were conducted in Kieni, Central Kenya where the rainfall pattern was bimodal. The planting for rain-fed crops was done in three blocks each measuring 10m x1m with a spacing of 30cm between plants and 45cm between rows of plants and the procedure repeated for the crops receiving SI. The average weekly yields were computed for both crops for each season comprised of 14 weeks. The average weekly yields were subjected to Analysis of Variance (ANOVA) to determine whether the average yields from rain-fed and supplemental irrigated crops were statistically different. This was done by MS Excel 2016 spread sheets by setting a statistical level of significance of 5%. F value was 17.94 higher than the critical value of 4.01 while the P-value of 9x10-5 was lower than the 5% level of confidence meaning that there was a significant difference in the yield means of rain-fed and SI crops. The total rain-fed crop yields for the period was 147.0 Kgs and that of the one under SI was 238Kgs, an increase of about 62%. Therefore, supplemental irrigation can be adopted in areas where rainfall trends are declining to increase crop yields when all other factors remain constant for farmers to increase resilience.

Li D, Zhang Y, Guo Q, Sun X, Zhang H, Wang S, Birech Z, Hu J. "An efficient LSPR method to quantitatively detect dimethoate: Development, characterization and evaluation. ." Plos one. 2020;15(9):e0239632.
Kaunda, Mwea, Dulo. "Emissions of Vehicular Traffic along Uhuru Highway Corridor in Nairobi." Journal of Engineering and Architecture. 2020;8(2):22-27.
G M, G MI, J M. "End-of-Life Care Education Needs OF Nurses: A Cross-Sectional Study." Annals of Nursing and Practice. 2020;7(1).
Mwangi M, Kituyi E, Ouma G. "Enhancing adoption of climate services through an innovation systems approach." Scientific African. 2020:e00445. Abstractdoi.org

Abstract
Recent years have marked the emergence of the innovation systems approach as a shift from the conventional linear models of technology transfer. Linear technology diffusion models hinder participatory approaches of local actors such as smallholder farmers and regards them as spectators in the development process, which impedes wide adoption of technology by the intended beneficiary. This article sought to understand the potential of the innovations systems approach as an incentive to enhance the adoption of climate services by smallholder farmers through regarding them and other relevant stakeholders as part of the process, fostering knowledge sharing and interactive learning. The methodology included stakeholder/actor identification, mapping of stakeholder linkages, capacity building and active involvement of stakeholders through the climate services process. The results showed that unlike the conventional linear knowledge delivery process, the innovation systems approach takes into consideration the complex processes that are highlighted by non-linear processes, feedback loops, and other complex interactions that occur among heterogeneous actors. As such in place of the linear knowledge delivery approach, a more systems approach is necessary to help mobilize science and technology such as climate services to deliver benefits, which has the potential to enhance access, salience, credibility, and legitimacy of the scientific information.

Keywords
Innovation systems approach; Climate services; Stakeholder linkages; Adoption

Bauza V, Madadi V, Ocharo R, Nguyen TH, Guest JS. "Enteric pathogens from water, hands, surface, soil, drainage ditch, and stream exposure points in a low-income neighborhood of Nairobi, Kenya." Science of The Total Environment. 2020;709:135344. AbstractScience of The Total Environment

Description
Child exposure to fecal-oral pathogens occurs through several transmission pathways. However, the relative importance of different exposure points for pathogen transmission both inside and outside households is not well understood. We conducted a cross-sectional study in the urban slum of Kibera in Nairobi, Kenya, collecting 237 environmental samples from 40 households from source water, stored drinking water, caregiver hands, child hands, household surfaces, soil, standing water, open drainage ditches, and streams. We quantified the fecal indicator Escherichia coli and the enteric pathogens of adenovirus, Campylobacter jejuni, Shigella spp./enteroinvasive E. coli (EIEC), and Vibrio cholerae. At least one enteric pathogens was detected in 13% of household stored water, 47% of hand, 46% of table surface, 26% of plate surface, 75% of floor surface, 96% of soil, 56% of standing water, 77% of drainage ditch …

Bauza V, Madadi V, Ocharo R, Nguyen TH, Guest JS. "Enteric pathogens from water, hands, surface, soil, drainage ditch, and stream exposure points in a low-income neighborhood of Nairobi, Kenya." Science of The Total Environment. 2020;709(March 2020):135344.
Okumu MO, Mbaria JM, Gikunju JK, Mbuthia PG, Madadi VO, Ochola FO. "Enzymatic activity and brine shrimp lethality of venom from the large brown spitting cobra (Naja ashei) and its neutralization by antivenom." BCM Research Notes. 2020;13(25):1-7.
Urinayo V. KODKA. "Erratic Rainfall Patterns Impact on Water Quality of Yanze River, Kigali Rwanda." Journal of Climate Change and Sustainability. 2020;3(2):49-57.
Wanjala G, Ongosi BO. "Establishing the Impact of Double-Intake Programmes on the Physical Infrastructural Learning Environment at the University of Nairobi, Kenya." International Journal of Innovative Research and Knowledge . 2020;5(2):17-29 .abstract.pdf
Kipchirchir IC. "ESTIMATINGAN EXPONENTIALLY DECAYINGFUNCTION OF RATE PARAMETER OF APOISSON PROCESS." Advances and Applications in Statistics. 2020;6(1):1-17. AbstractWebsite

In this paper, we consider point estimation of an exponentiallydecaying function of rate parameter of Poisson process usingdiscrete (increments) and continuous (interarrival times) variablesundermaximum likelihood and minimum variance paradigms. It isfound that for increments, momentsof estimators are in terms ofelementary function-the exponential function whereas for interarrivaltimes, moments of estimators are in terms of special functions-modified Bessel function ofthethirdkind for maximum likelihoodestimators and confluent hypergeometric function for the uniformlyminimum variance unbiased estimators. Behaviourally, the momentsmirror the exponentially decaying function of. The maximumlikelihood estimators are biased, however, it is found thatasymptoticunbiasedness forfixedn wheren is the sample size corresponds to a

Peter Aweer Duot Ajak, GACHUIRI CHARLESK, Wanyoike MMM. "Evaluation of Dairy Cattle Productivity in Smallholder Farms in Nyeri County, Kenya." East African Journal of Science, Technology and Innovation. 2020;2(1).
Ronoh M, Chirove F, Wairimu J, Ogana W. "Evidence-based modeling of combination control on Kenyan youth HIV/AIDS dynamics." PloS one. 2020;15(11):0242491. AbstractWebsite

We formulate a sex-structured deterministic model to study the effects of varying HIV testing rates, condom use rates and ART adherence rates among Adolescent Girls and Young Women (AGYW) and, Adolescent Boys and Young Men (ABYM) populations in Kenya. Attitudes influencing the Kenyan youth HIV/AIDS control measures both positively and negatively were considered. Using the 2012 Kenya AIDS Indicator Survey (KAIS) microdata we constructed our model, which we fitted to the UNAIDS-Kenya youth prevalence estimates to understand factors influencing Kenyan youth HIV/AIDS prevalence trends. While highly efficacious combination control approach significantly reduces HIV/AIDS prevalence rates among the youth, the disease remains endemic provided infected unaware sexual interactions persist. Disproportional gender-wise attitudes towards HIV/AIDS control measures play a key role in reducing the Kenyan youth HIV/AIDS prevalence trends. The female youth HIV/AIDS prevalence trend seems to be directly linked to increased male infectivity with decreased female infectivity while the male youth prevalence trend seems to be directly associated with increased female infectivity and reduced male infectivity.

Magutu PO, Inyega JO, Nyaanga RO. Evidence-based training assessment approaches and methodologies in procurement planning and supply chain managemen. Knowledge Empowerment Foundation. ISBN: 978-81-942015-4-0; 2020.
Kabue KG, Njogu PM, Mwangi AN. "Exploring different approaches to improve the success of drug discovery and development projects." Futur. J. Pharm. Sci. 2020;6:27.
Muasya, Juliet N, Kahiga, Ruth W. "Exploring Men and Women Students Experiences of Sexual Harassment: A Case Study of one Public University in Kenya." International Journal of Gender and Women’s Studies . 2020;8 (2):122-130.
Musa AM, Wasonga OV, Mtimet N. "Factors influencing livestock export in Somaliland’s terminal markets." Pastoralism Research, Policy and Practice . 2020;10(2020 10:1 https://doi.org/10.1186/s13570-019-0155-7).factors_influencing_livestock_export_in_somaliland._musa_et_al._2020.pdf
Mburu J, Mbogoh SG, Bundi A, Ambuko JL. "Factors influencing the adoption of pre-harvest practices among mango farmers in Embu and Machakos counties, Kenya." International Journal of Postharvest Technology and Innovation. 2020;Vol. 7(1):pp.56-72.
Mbogoh SG, Ambuko JL, Mburu J, Bundi A. "Factors influencing the adoption of pre-harvest practices among mango farmers in Embu and Machakos counties, Kenya." International Journal of Postharvest Technology and Innovation. 2020;Vol. 7(1):pp.56-72.
Wamitila KW. "Factual and Fictional Narratives in East African Literatures.". In: NARRATIVE FACTUALITY: A HANDBOOK EDITED BY: MONIKA FLUDERNIK & MARIE-LAURE RYAN . Berlin/ Boston: De Gruyter; 2020.
Muthini D, Nzuma J, Nyikal R. "Farm production diversity and its association with dietary diversity in Kenya." Food Security. 2020;https://doi.org/10.1007/s12571-020-01030-1.
Kasule F, Wasswa P, Mukasa SB, Okiror A, Nghituwamhata SN, Rono EC, Mukuze C, Mwang’ombe AW. "Farmer Preference of Cassava Cultivars in Eastern Uganda: A Choice Beyond Disease Resistance." Agricultural Science. 2020;2(2):169-177.
Ndegwa R, Simiyu J, E Ayieta, Odero N. "A Fast and Accurate Analytical Method for Parameter Determination of a Photovoltaic System Based on Manufacturer’s Data." Journal of Renewable Energy. 2020;(2020):1-18.
Mitchell EJ, Qureshi ZP, Were F, Daniels J, Gwako G, Osoti A, Opira J, Bradshaw L, Oliver M, Pallotti P, Ojha S. "Feasibility of using an Early Warning Score for preterm or low birthweight infants in a low-resource setting: results of a mixed-methods study at a national referral hospital in Kenya." BMJ Open. 2020;10(10). AbstractWebsite

Abstract

Introduction: Fifteen million babies are born prematurely, before 37 weeks gestational age, globally. More than 80% of these are in sub-Saharan Africa and Asia. 35% of all deaths in the first month of life are due to prematurity and the neonatal mortality rate is eight times higher in low-income and middle-income countries (LMICs) than in Europe. Early Warning Scores (EWS) are a way of recording vital signs using standardised charts to easily identify adverse clinical signs and escalate care appropriately. A range of EWS have been developed for neonates, though none in LMICs. This paper reports the findings of early work to examine if the use of EWS is feasible in LMICs.

Methods: We conducted an observational study to understand current practices for monitoring of preterm infants at a large national referral hospital in Nairobi, Kenya. Using hospital records, data were collected over an 8-week period in 2019 on all live born infants born at <37 weeks and/or <2500 g (n=294, 255 mothers) in the first week of life. Using a chart adopted from the EWS developed by the British Association of Perinatal Medicine, we plotted infants' vital signs. In addition, we held group discussions with stakeholders in Kenya to examine opinions on use of EWS.

Results: Recording of vital signs was variable; only 63% of infants had at least one temperature recorded and 53% had at least one heart rate and respiratory rate recorded. Stakeholders liked the traffic-light system and simplicity of the chart, though recognised challenges, such as staffing levels and ability to print in colour, to its adoption.

Conclusion: EWS may standardise documentation and identify infants who are at higher risk of an adverse outcome. However, human and non-human resource issues would need to be explored further before development of an EWS for LMICs.

V O, A A, A K. "Fertility transition in selected sub-Saharan African countries: the role of family planning programs ." F1000Research. 2020;8(1748). AbstractWebsite

Change in fertility rate across societies is a complex process that involves changes in the demand for children, the diffusion of new attitudes about family planning and greater accessibility to contraception. Scholars have concentrated on a range of factors associated with fertility majorly at the national scale. However, considerably less attention has been paid to fertility preference - a pathway through which various variables act on fertility. It is understood that women have inherent fertility preferences which each they seek to achieve over her reproductive cycle. However, the service delivery enhancement levels and capacity across countries as integral pathways to this goal accomplishment stand on their way towards eventual outcomes. Precisely, the Sub-Saharan African countries’ disparities amid similarities in their population policies is a cause of concern.

Bohlin-Nizzetto P, Melymuk L, B.White K, Kalina J, Madadi VO, SamAdu-Kumi, Prokeš R, Přibylová P, Klánová J. "Field- and model-based calibration of polyurethane foam passive air samplers in different climate regions highlights differences in sampler uptake performance." Atmospheric Environment. 2020;238(117742).
Otieno SP. File A222. Kimondo W, ed. Talent Empire; 2020.
Chitedze I, Nwedeh CC, Ang’u C. "Financial Modelling of Feed-In Tariff for Increasing Solar Photovoltaic Energy Portfolio in Malawi." Journal of Energy and Natural Resources. 2020;9(1):14-27.
Karuma AN, PT G, CKK G. "Financial returns of maize and bean production under selected tillage practices in semi-arid area of Mwala Sub County, Kenya." Asian Journal of Agricultural Extension, Economics and Sociology. 2020;38(10):11-23.
Waruiru RM, Mbuthia PG, Bebora LC, Nyaga PN, Wanja DW, Mwadime JM, Ngowi HA. "Fish husbandry practices and water quality in central Kenya: potential risk factors for fish mortality and infectious Diseases." Hindawi Veterinary Medicine International . 2020;2020.
Wanja DW, Mbuthia PG, Waruiru RM, Mwandime JM, Bebora LC, Nyaga PN, Ngowi, H. "Fish husbandry practices and water quality in central Kenya: Potential risk factors for fish mortality and infectious diseases." Veterinary Medicine International. 2020;2020.
Bebora LC, Mbuthia PG, Nyaga PN, Waruiru RM, Wanja DW, H.A N. "Fish Husbandry Practices and Water Quality in Central Kenya: Potential Risk Factors for Fish Mortality and Infectious Diseases." Hindawi Veterinary Medicine International . 2020;2020.abstract.pdf
Derese S. "Flavonoids and Isoflavonoids of Millettia dura and Millettia ferruginea: Phytochemical review and chemotaxonomic values." Biochemical Systematics and Ecology. 2020;91. Abstract

The phytochemical information on Millettia dura Dunn, M. ferruginea (Hochst.) Baker and M. ferruginea subsp. darassana (Cufod.) J.B. Gillett was reviewed. All the three taxa elaborate mainly isoflavones (33 reported), occurring in the flowers, seeds/seed pods, stem bark and root bark. Out of the 33 isoflavones reported, some 19 (ca. 58%) contain prenyl at C-8 or its modification as 2,2-dimethylchromene ring at C-7/C-8, occurring in all the three taxa. Except for three isoflavones isolated from M. ferruginea subsp. darassana, all the isoflavones of these taxa are 5-deoxygenated. In these taxa, oxygenation at C-6 is a common feature, while isoflavones with C-8 oxygenation are rare, only three reported, and all of these from M. dura. There are 7 rotenoids reported from these taxa, and occur almost entirely in the seeds/seedpods of these plants. The major rotenoid with methylenedioxy group at C-2/C-3, millettone and its 12a-hydroxy derivative, millettosine, occur only in M. dura, this appears to distinguish M. dura from M. ferruginea.

Buyinza D, Chalo DM, Derese S, Ndakala A, Yenesew A. "Flavonoids and Isoflavonoids of Millettia dura and Millettia ferruginea: Phytochemical review and chemotaxonomic values." Biochemical Systematics and Ecology. 2020;91:104053. AbstractBiochemical Systematics and Ecology

Description
The phytochemical information on Millettia dura Dunn, M. ferruginea (Hochst.) Baker and M. ferruginea subsp. darassana (Cufod.) J.B. Gillett was reviewed. All the three taxa elaborate mainly isoflavones (33 reported), occurring in the flowers, seeds/seed pods, stem bark and root bark. Out of the 33 isoflavones reported, some 19 (ca. 58%) contain prenyl at C-8 or its modification as 2,2-dimethylchromene ring at C-7/C-8, occurring in all the three taxa. Except for three isoflavones isolated from M. ferruginea subsp. darassana, all the isoflavones of these taxa are 5-deoxygenated. In these taxa, oxygenation at C-6 is a common feature, while isoflavones with C-8 oxygenation are rare, only three reported, and all of these from M. dura. There are 7 rotenoids reported from these taxa, and occur almost entirely in the seeds/seedpods of these plants. The major rotenoid with methylenedioxy group at C-2/C-3, millettone and its …

Buyinza D, Chalo DM, Derese S, Ndakala A, Yenesew A. "Flavonoids and Isoflavonoids of Millettia dura and Millettia ferruginea: Phytochemical review and chemotaxonomic values." Biochemical Systematics and Ecology. 2020;91:104053. AbstractBiochemical Systematics and Ecology

Description
The phytochemical information on Millettia dura Dunn, M. ferruginea (Hochst.) Baker and M. ferruginea subsp. darassana (Cufod.) J.B. Gillett was reviewed. All the three taxa elaborate mainly isoflavones (33 reported), occurring in the flowers, seeds/seed pods, stem bark and root bark. Out of the 33 isoflavones reported, some 19 (ca. 58%) contain prenyl at C-8 or its modification as 2,2-dimethylchromene ring at C-7/C-8, occurring in all the three taxa. Except for three isoflavones isolated from M. ferruginea subsp. darassana, all the isoflavones of these taxa are 5-deoxygenated. In these taxa, oxygenation at C-6 is a common feature, while isoflavones with C-8 oxygenation are rare, only three reported, and all of these from M. dura. There are 7 rotenoids reported from these taxa, and occur almost entirely in the seeds/seedpods of these plants. The major rotenoid with methylenedioxy group at C-2/C-3, millettone and its …

Focus Grade 5 Kiswahili. . Nairobi: Focus publishers; 2020.
Focus Grade 5 T/G.. Nairobi: Focus publishers; 2020.
Okaru AO, Lachenmeier DW. "The Food and Beverage Occurrence of Furfuryl Alcohol and Myrcene-Two Emerging Potential Human Carcinogens.". In: Analysis of Chemical Contaminants in Food. Basel: mdpi; 2020.
"Formal Features in Alex la Guma’s “Come Back to Tashkent." Asian Journal of African Studies,. 2020;47(1):99-119.
Mwangi M, Tirop L, Njogu P, Bururia J, Mwaura N, Mbae E. "Formulation of dispersible isoniazid/pyridoxine fixed-dose combination tablets for isoniazid-preventive therapy in paediatrics." Cogent Med. 2020;7(1):1787684.
Bonet M, Brizuela V, Abalos E, Cuesta C, Baguiya A, Group TWHOGMSS(GLOSS) R. "Frequency and management of maternal infection in health facilities in 52 countries: Results of the WHO Global Maternal Sepsis Study (GLOSS), a one-week inception cohort." Lancet Global Health. . 2020;8(5):661-671. AbstractWebsite

Background
Maternal infections are an important cause of maternal mortality and severe maternal morbidity. We report the main findings of the WHO Global Maternal Sepsis Study, which aimed to assess the frequency of maternal infections in health facilities, according to maternal characteristics and outcomes, and coverage of core practices for early identification and management.
Methods
We did a facility-based, prospective, 1-week inception cohort study in 713 health facilities providing obstetric, midwifery, or abortion care, or where women could be admitted because of complications of pregnancy, childbirth, post-partum, or post-abortion, in 52 low-income and middle-income countries (LMICs) and high-income countries (HICs). We obtained data from hospital records for all pregnant or recently pregnant women hospitalised with suspected or confirmed infection. We calculated ratios of infection and infection-related severe maternal outcomes (ie, death or near-miss) per 1000 livebirths and the proportion of intrahospital fatalities across country income groups, as well as the distribution of demographic, obstetric, clinical characteristics and outcomes, and coverage of a set of core practices for identification and management across infection severity groups.
Findings
Between Nov 28, 2017, and Dec 4, 2017, of 2965 women assessed for eligibility, 2850 pregnant or recently pregnant women with suspected or confirmed infection were included. 70·4 (95% CI 67·7–73·1) hospitalised women per 1000 livebirths had a maternal infection, and 10·9 (9·8–12·0) women per 1000 livebirths presented with infection-related (underlying or contributing cause) severe maternal outcomes. Highest ratios were observed in LMICs and the lowest in HICs. The proportion of intrahospital fatalities was 6·8% among women with severe maternal outcomes, with the highest proportion in low-income countries. Infection-related maternal deaths represented more than half of the intrahospital deaths. Around two-thirds (63·9%, n=1821) of the women had a complete set of vital signs recorded, or received antimicrobials the day of suspicion or diagnosis of the infection (70·2%, n=1875), without marked differences across severity groups.
Interpretation
The frequency of maternal infections requiring management in health facilities is high. Our results suggest that contribution of direct (obstetric) and indirect (non-obstetric) infections to overall maternal deaths is greater than previously thought. Improvement of early identification is urgently needed, as well as prompt management of women with infections in health facilities by implementing effective evidence-based practices.

Masila VM, Ndakala AJ, Midiwo JO, Byamukama R, Kamau RW, Kumarihamy M, Muhammad I. "Full View Synthesis of a pyrrolidine derivative of a carvotacetone and monoterpenes for anti-methicillin-resistant Staphylococcus aureus and anti-cryptococcal properties." Natural Product Research. 2020:1-8. AbstractNatural Product Research

Abstract
Monoterpene derivatives are of great biological relevance in the pharmaceutical industry. In the present study, pyrrolidine derivative of a carvotacetone, 3-O-benzylcarvotacetone (1), and selected monoterpenes (3-hydroxy-2-isopropyl-5-methyl-p-benzoquinone (3) and cis-piperitol (5)) were prepared to provide (R)-1-(4-(benzyloxy)-5-isopropyl-2-methylcyclohexa-1,3-dien-1-yl)-pyrrolidine (2), 2-isopropyl-5-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl acetate (4), cis-3-hydroxypiperitone (6) and carvacrol (7). Structure of 2 was determined based on NMR and HRMS spectral data. Compound 4 exhibited activity against fungi Cryptococcus neoformans with an IC50 value of < 0.8 µg/mL. In addition, this compound 4 had an IC50 value of 14.97 µg/mL against methicillin resistant Staphylococcus aureus bacteria. Previous to the current study, both compound 6 and 7 had been reported to have anti-microbial and anti-fungal activities.

Graphical abstract
Keywords: MonoterpenesCarvacrolCis-3-hydroxypiperitoneAnti-MRSAAnti-cryptococcal

Lachenmeier DW, Teipel J, Scharinger A, Kuballa T, Walch SG, Grosch F, Bunzel M, Okaru AO, Schwarz S. "Fully automated identification of coffee species and simultaneous quantification of furfuryl alcohol using NMR spectroscopy." J AOAC Int .. 2020;103(2):306-314.
Orata D. Fundamentals of Electrochemistry. Germany: Lambert Academic Publisher; 2020. AbstractLap Lambert Academic Publishing

Fundamentals of Electrochemistry is a text which discusses all aspects of the electrochemical processes. This includes, discussions ranging from primary definition of terms in electrochemistry to solution of advanced electrochemical equations which is key in explaining the various electrode processes. The textbook is ideal for senior undergraduate and postgraduate students in Universities.

A M. "Fungal Biomass Load and Aspergillus flavus in a Controlled Environment.". In: Biotechnological Applications of Biomass. intechopen.com; 2020.
Wanyonyi LS. "Further remarks on unitary equivalence of some classes of operators in Hilbert spaces." International Journal of Statistics and Applied Mathematics. 2020;5(3):06-10. Abstractfull text

In this paper we investigate results on unitary equivalence of operators that include n-binormal, skew
binormal and n-power-hyponormal operators acting on complex Hilbert space H.
AMS subject classification 47B47, 47A30, 47B20.

Kamunyu R, Ndungo C. "Gender Preference of Counsellors among University Students Seeking Counselling Services." IOSR Journal Of Humanities And Social Science (IOSR-JHSS). 2020;25(2):20-28.
"Gendered Analysis of the Demand for Poultry Feed in Kenya. ." Agricultural Economics Research, Policy and Practice in Southern Africa – Agrekon. 2020;(ISSN: 0303-1853 ).
Nyang'au EM, Bulimo WD, Mobegi V, Opanda S, Magiri E. "Genetic Analysis of HA1 Domain of Influenza A/H3N2 Viruses Isolated in Kenya During the 2007 to 2013 Seasons Reveal Significant Divergence from WHO-Recommended Vaccine Strains." Int J Infect Dis. 2020. Abstractnyagau_et_al_2020.pdf

BACKGROUND: Influenza viruses evolve rapidly and cause regular seasonal epidemics in humans challenging effective vaccination. The virus surface HA glycoprotein is the primary target for the host immune response. Here, we investigated the vaccine efficacy and evolution patterns of human influenza A/H3N2 viruses that circulated in Kenyan in the period before and after the 2009 A/H1N1 pandemic, targeting the HA1 domain. MATERIALS AND METHODS: A hundred and fifteen HA sequences of Kenyan virus viruses were analyzed relative to the corresponding WHO vaccine reference strains using bioinformatics approaches. RESULTS: Our analyses revealed varied amino acid substitutions at all the five antigenic sites (A-E) of the HA1 domain, with a majority the changes occurring at sites A and B. The Kenyan A/H3N2 viruses isolated during 2007/2008 seasons belonged to A/Brisbane/10/2007- like viruses lineage, while those circulating in 2009 to 2012 belonged to the lineage of A/Victoria/361/2011-like viruses. The 2013 viruses clustered in clade 3C.3 of the A/Samara/73/2013-like viruses. The mean evolutionary rate of the A/H3N2 viruses analyzed in the study was at 4.17×10(-3) (95% HPD=3.09×10(-3) to 5.31×10(-3)) nucleotide substitutions per site per year, whereas the TMRCA was estimated at 11.18 (95% HPD=9.00-14.12) years ago from 2013. The Prediction of vaccine efficacy revealed modest vaccine efficaciousness during 2008, and 2010 influenza seasons, whilst sub-optimal effectiveness was registered in 2007,2009, 2012 and 2013. Further, the overall selective pressure acting on the HA1 domain was estimated at 0.56 (ω<1), suggesting that a majority of codon sites in the HA1 epitopes were evolving under purifying selection. CONCLUSIONS: Generally, our results highlight the genetic plasticity of A/H3N2 viruses and reveal considerable disparity in vaccine efficaciousness against the A/H3N2 viruses that circulated in Kenya, specifically during 2007,2009, 2012, and 2013 influenza seasons. Our findings underscore the importance and need for consistent surveillance and molecular characterization of influenza viruses, to inform decision making and enhance early of detection of strains with epidemic/pandemic potential as well as benefit in guiding decisions regarding the appropriate annual influenza vaccine formulations.

Elusah J, Bulimo WD, Opanda SM, Symekher SL, Wamunyokoli F. "Genetic diversity and evolutionary analysis of human respirovirus type 3 strains isolated in Kenya using complete hemagglutinin-neuraminidase (HN) gene." PLOS ONE. 2020;15(3):e0229355. Abstractelusa_et_al_2020.pdfWebsite

Human respirovirus type 3 (HRV3) is a leading etiology of lower respiratory tract infections in young children and ranks only second to the human respiratory syncytial virus (HRSV). Despite the public health importance of HRV3, there is limited information about the genetic characteristics and diversity of these viruses in Kenya. To begin to address this gap, we analyzed 35 complete hemagglutinin-neuraminidase (HN) sequences of HRV3 strains isolated in Kenya between 2010 and 2013. Viral RNA was extracted from the isolates, and the entire HN gene amplified by RT-PCR followed by nucleotide sequencing. Phylogenetic analyses of the sequences revealed that all the Kenyan isolates grouped into genetic Cluster C; sub-clusters C1a, C2, and C3a. The majority (54%) of isolates belonged to sub-cluster C3a, followed by C2 (43%) and C1a (2.9%). Sequence analysis revealed high identities between the Kenyan isolates and the HRV3 prototype strain both at the amino acid (96.5–97.9%) and nucleotide (94.3–95.6%) levels. No amino acid variations affecting the catalytic/active sites of the HN glycoprotein were observed among the Kenyan isolates. Selection pressure analyses showed that the HN glycoprotein was evolving under positive selection. Evolutionary analyses revealed that the mean TMRCA for the HN sequence dataset was 1942 (95% HPD: 1928–1957), while the mean evolutionary rate was 4.65x10-4 nucleotide substitutions/site/year (95% HPD: 2.99x10-4 to 6.35x10-4). Overall, our results demonstrate the co-circulation of strains of cluster C HRV3 variants in Kenya during the study period. This is the first study to describe the genetic and molecular evolutionary aspects of HRV3 in Kenya using the complete HN gene.

Cheserek JJ, Ngugi K, Muthomi JW, Omondi CO. "Genetic variability, heritability and correlation of quantitative traits for Arabusta coffee (C. arabica L. X Tetraploid C. canephora Pierre)." Journal of Plant Breeding and Crop Science. 2020;12(1):50-57.
Astère Bararyenya, Bode A. Olukolu, Phinehas Tukamuhabwa, Wolfgang J. Grüneberg, Ekaya W, Jan Low, Mildred Ochwo-Ssemakula TOL. "Genome-wide association study identified candidate genes controlling continuous storage root formation and bulking in hexaploid sweetpotato." BMC Plant Biology . 2020;20(1):1-16.
SM Mwendwa, Mbuvi JP, Kironchi G, Gachene CKK. "A geopedological approach to soil classification to characterize soils of Upper Kabete Campus Field, University of Nairobi, Kenya ." Tropical and Subtropical Agroecosystems. 2020.
SM Mwendwa, Mbuvi JP, Kironchi G, Gachene CKK. "A geopedological approach to soil classification to characterize soils of Upper Kabete Campus Field, University of Nairobi, Kenya ." Tropical and Subtropical Agroecosystems. 2020.
Chebii WK, John M, Karatu K. "The governance of traditional medicine and herbal remedies in the selected local markets of Western Kenya." Journal of Ethnobiology and Ethnomedicine . 2020;39(16).
Elsayed HM, Wadee S, Zaki MS, Were AJO, Ashuntantang GE, Bamgboye EL, Davids MR, Hafez MH, Mahamat M, Naicker S, Niang A, Seck SM, Swanepoel CR, Tannor EK, Twahir A, Yao HK. "Guidelines for the prevention, detection and management of the renal complications of COVID-19 in Africa." African Journal of Nephrology. 2020;98(5):S117-S134.Website
Waruiru RM, Mbuthia PG, Bebora LC, Nguhiu JM, Wamboi P. "Haemato- biochemical changes and prevalence of parasitic infections of indigenous chicken sold in markets of Kiambu County, Kenya." International Journal of Veterinary Science and Medicine. 2020;8(1):18-25.
Wamboi P, Waruiru RM, Mbuthia PG, Nguhiu-Mwangi J, Bebora LC. "Haemato-biochemical changes and prevalence of parasitic infections of indigenous chicken sold in markets of Kiambu County, Kenya, ." International Journal of Veterinary Science and Medicine. 2020;8(1):18-25.
Susan Gachau, Matteo Quartagno, NJAGI EDMUNDNJERU, Nelson Owuor, English M, Ayieko P. "Handling missing data in modelling quality of clinician-prescribed routine care: sensitivity analysis of departure from missing at random assumption." Statistical methods in medical research. 2020;29(10):3076-3092. AbstractWebsite

Missing information is a major drawback in analyzing data collected in many routine health care settings. Multiple imputation assuming a missing at random mechanism is a popular method to handle missing data. The missing at random assumption cannot be confirmed from the observed data alone, hence the need for sensitivity analysis to assess robustness of inference. However, sensitivity analysis is rarely conducted and reported in practice. We analyzed routine paediatric data collected during a cluster randomized trial conducted in Kenyan hospitals. We imputed missing patient and clinician-level variables assuming the missing at random mechanism. We also imputed missing clinician-level variables assuming a missing not at random mechanism. We incorporated opinions from 15 clinical experts in the form of prior distributions and shift parameters in the delta adjustment method. An interaction between trial intervention arm and follow-up time, hospital, clinician and patient-level factors were included in a proportional odds random-effects analysis model. We performed these analyses using R functions derived from the jomo package. Parameter estimates from multiple imputation under the missing at random mechanism were similar to multiple imputation estimates assuming the missing not at random mechanism. Our inferences were insensitive to departures from the missing at random assumption using either the prior distributions or shift parameters sensitivity analysis approach

Mwangi S, Abuga K, Mungai N, Mwangi J. "A High Performance Liquid Chromatography Method for the Determination of Artemisinin in Artemisia annua L. Leaf Extracts." East Cent. Afr. J. Pharm. Sci. . 2020;23(2):48-53. Abstract

A simple, sensitive, accurate and precise high performance liquid chromatography (HPLC) method for determination of artemisinin in crude plant material was developed and validated. Optimal separation of artemisinin from matrix components in the plant extracts was achieved using a Waters XTerra® RP18 , 5 m, 250 × 4.6 mm column, maintained at 40 °C, a mobile phase consisting of 0.05 M potassium phosphate buffer, pH 6.0 - acetonitrile (60:40) containing 5 mM hexane sulfonate in isocratic flow. The mobile phase flow rate was 1.0 ml/min while elution was monitored at 216 nm. The method satisfied the International Conference on Harmonization (ICH) validation criteria for linearity, accuracy, precision and sensitivity. The developed method is applicable in routine quality control of Artemisia annua crude extracts.

Jane Ireri, Pokhariyal G, Moindi S. "Hopf Bifurcation Analysis for a Two Species Periodic Chemostat Model with Discrete Delays." Journal of Advances in Mathematics and Computer Science. 2020;35(3):93-105. AbstractWebsite

In this paper we analyze a Chemostat model of two species competing for a single limiting nutrient input varied periodically using a Fourier series with discrete delays. To understand global aspects of the dynamics we use an extension of the Hopf bifurcation theorem, a method that rigorously establishes existence of a periodic solution. We show that the interior equilibrium point changes its stability and due to the delay parameter it undergoes a Hopf bifurcation.
Numerical results shows that coexistence is possible when delays are introduced and Fourier series produces the required seasonal variations. We also show that for small delays periodic variations of nutrients has more influence on species density variations than the delay.

"How Are Husbands to Know about the Health of Their Menopausal Wives? Kisima." An Ecumenical Magazine for Christian Mothers. 2020;1(1): 20-22.
Tanui F, Olago D, Dulo SI, Ouma G, Kuria Z. "Hydrogeochemistry of a strategic alluvial aquifer system in a semi-arid setting and its implications for potable urban water supply: The Lodwar Alluvial Aquifer System (LAAS)." Groundwater for Sustainable Development. 2020;11:100451. Abstractdio.org

Lodwar Municipality is one of the fastest-growing urban areas of Sub-Saharan Africa that depends mainly on groundwater for its municipal water supply. Most of the groundwater sources are located within the riparian zones of the Turkwel River. With limited understanding of its aquifers, the groundwater of Lodwar may be at risk of natural processes and anthropogenic activities. Statistical techniques and geochemical methods were applied to determine the aquifer hydrogeochemistry. Three distinct aquifers, which we collectively refer to as the Lodwar Alluvial Aquifer System, underlie Lodwar and its environs, the shallow alluvial, intermediate, and deep aquifers which are the main source of fresh water. A fourth, the shallow aquifer of the Turkana grit, is highly saline and with fluoride contamination. Just as the Turkwel River, the shallow alluvial aquifer (SAA) was dominated by Ca–HCO3 water type, while the TGSA was Na–Cl water type and became Na–HCO3 near the Holocene sediments. The intermediate aquifer (IA) was Na–HCO3water type. Pockets of Mg–HCO3 water occurred in the shallow alluvial and intermediate aquifers. The natural processes in the SAA include rock-water interaction, recharge by surface water, and oxidation reactions, while evaporation and dissolution are the major factors controlling the chemistry of the TGSA. Ion exchange, dilution, and dissolution are the major processes in the IA. Elevated levels of NO3− and SO42− during the wet season within the SAA and the IA reflects their vulnerability to pollution. Saline intrusion into the shallow and intermediate aquifers from the Turkana grit aquifers is likely to occur.

Tanui F, Olago D, Dulo SI, Ouma G, Kuria Z. "Hydrogeochemistry of a strategic alluvial aquifer system in a semi-arid setting and its implications for potable urban water supply: The Lodwar Alluvial Aquifer System (LAAS)." Groundwater for Sustainable Development. 2020;11:100451. Abstractdio.org

Lodwar Municipality is one of the fastest-growing urban areas of Sub-Saharan Africa that depends mainly on groundwater for its municipal water supply. Most of the groundwater sources are located within the riparian zones of the Turkwel River. With limited understanding of its aquifers, the groundwater of Lodwar may be at risk of natural processes and anthropogenic activities. Statistical techniques and geochemical methods were applied to determine the aquifer hydrogeochemistry. Three distinct aquifers, which we collectively refer to as the Lodwar Alluvial Aquifer System, underlie Lodwar and its environs, the shallow alluvial, intermediate, and deep aquifers which are the main source of fresh water. A fourth, the shallow aquifer of the Turkana grit, is highly saline and with fluoride contamination. Just as the Turkwel River, the shallow alluvial aquifer (SAA) was dominated by Ca–HCO3 water type, while the TGSA was Na–Cl water type and became Na–HCO3 near the Holocene sediments. The intermediate aquifer (IA) was Na–HCO3water type. Pockets of Mg–HCO3 water occurred in the shallow alluvial and intermediate aquifers. The natural processes in the SAA include rock-water interaction, recharge by surface water, and oxidation reactions, while evaporation and dissolution are the major factors controlling the chemistry of the TGSA. Ion exchange, dilution, and dissolution are the major processes in the IA. Elevated levels of NO3− and SO42− during the wet season within the SAA and the IA reflects their vulnerability to pollution. Saline intrusion into the shallow and intermediate aquifers from the Turkana grit aquifers is likely to occur.

Mitchell EJ, Benjamin S, Ononge S, Ditai J, QURESHI ZAHIDA, Masood SN, Whitham D, Godolphin PJ, Duley L. "Identifying women giving birth preterm and care at the time of birth: a prospective audit of births at six hospitals in India, Kenya, Pakistan and Uganda." BMC Pregnancy Childbirth . 2020;20(439). AbstractWebsite

Background
Globally, 15 million infants are born preterm each year, and 1 million die due to complications of prematurity. Over 60% of preterm births occur in Sub-Saharan Africa and south Asia. Care at birth for premature infants may be critical for survival and long term outcome. We conducted a prospective audit to assess whether women giving birth preterm could be identified, and to describe cord clamping and neonatal care at hospitals in Africa and south Asia.

Methods
This prospective audit of livebirths was conducted at six hospitals in Uganda, Kenya, India and Pakistan. Births were considered preterm if between 28+ 0 and 33+ 6 weeks gestation and/or the birthweight was 1.00 to 1.99 kg. A pre-specified audit plan was agreed with each hospital. Livebirths before 28 weeks gestation with birthweight less than 1.0 kg were excluded. Data were collected on estimated and actual gestation and birthweight, cord clamping, and neonatal care.

Results
Of 4149 women who gave birth during the audit, data were available for 3687 (90%). As 107 were multiple births, 3781 livebirths were included, of which 257 (7%) were preterm. Antenatal assessment correctly identified 148 infants as ‘preterm’ and 3429 as ‘term’, giving a positive predictive value of 72% and negative predictive value of 97%. For term births, cord clamping was usually later at the two Ugandan hospitals, median time to clamping 50 and 76 s, compared with 23 at Kenyatta (Kenya), 7 at CMC (India) and 12 at FBH/LNH (Pakistan). At the latter two, timing was similar between term and preterm births, and between vaginal and Caesarean births. For all the hospitals, the cord was clamped quickly at Caesarean births, with Mbale (Uganda) having the highest median time to clamping (15 s ‘term’, 19 ‘preterm’). For preterm infants temperature on admission to the neonatal unit was below 35.5 °C for 50%, and 59 (23%) died before hospital discharge.

Conclusions
Antenatal identification of preterm birth was good. Timing of cord clamping varied between hospitals, although at each there was no difference between ‘term’ and ‘preterm’ births. For premature infants hypothermia was common, and mortality before hospital discharge was high.

Calistus N Ngonghala, Wairimu J, Jesse Adamski, Desai H. "IMPACT OF ADAPTIVE MOSQUITO BEHAVIOR AND INSECTICIDE-TREATED NETS ON MALARIA PREVALENCE." Journal of Biological Systems. 2020;28(2):515-542. AbstractWebsite

Malaria prevalence in sub-Saharan Africa remains high. Kenya for example, records about 3.5 million new cases and 11 thousand deaths each year.1 Most of these cases and deaths are among children under five. The main control method in malaria endemic regions has been through the use of insecticide-treated nets (ITNs). Although this approach has been fairly successful, the gains are threatened by mosquito-resistance to pyrethroids (insecticides on nets), physical and chemical degradation of ITNs that reduce their efficacy, inconsistent and improper use by humans, etc. We present a model to investigate the effects of ITN use and mosquito-resistance and adaptation to pyrethroids used to treat bed nets on malaria prevalence and control in malaria endemic regions. The model captures the development and loss of resistance to insecticides, the effects of ITN use on malaria control in a setting where proper and consistent use is not …

S. S, Gitau G.K., J. VL, C. M, P. K. "Impact of calf feeding practices on calf growth and health in smallholder dairy farms in Nyeri County, Kenya." East African Journal of Science, Technology, and Innovation. 2020;1(3):2707-0425.
Wanjala, G., Obutu OB. "Impact of Double-Intake Programmes on the Teacher Co-Efficient Determinant of Quality Education at the University of Nairobi,Kenya." International Journal of Educational Technology and Learning. 2020;8(1):16-24.abstract.pdf
MuswiiW. "The impact of ICT on society." TechNews. 2020;012(0012):3-5.
Nyang'au P, Muriithi B, Nzuma J, Irungu P, Gichungi H, Diiro G. "Impact of Integrated Fruit Fly Management Strategy on Food Security among Smallholder Mango Farmers in Kenya." African Journal of Food, Agriculture, Nutrition and Development. 2020;20(2):15431-15454.
Njeru N, Charles Midega, Muthomi J, Wagacha J, Zeyaur Khan. "Impact of push–pull cropping system on pest management and occurrence of ear rots and mycotoxin contamination of maize in western Kenya." Plant Pathology . 2020;69(9):1644-1654.
Njeru NK, Midega CAO, Muthomi JW, WAGACHA JOHNMAINA, Khan ZR. "In vitro antifungal activity of Desmodium intortum and D. uncinatum root extracts against growth of toxigenic Fusarium verticillioides and Aspergillus flavus." Australian Journal of Crop Science . 2020;14(12):1942-1948.
Kaigongi MM, Lukhoba CW, Yaouba S, Makunga NP, Githiomi J, Yenesew A. "In Vitro Antimicrobial and Antiproliferative Activities of the Root Bark Extract and Isolated Chemical Constituents of Zanthoxylum paracanthum Kokwaro (Rutaceae)." Plants. 2020;9(7):920. AbstractPlants

Description
Zanthoxylum paracanthum Kokwaro (Rutaceae) is an endemic Kenyan and Tanzanian plant used in folk medicine by local populations. Although other Zanthoxylum species have been studied, only Z. paracantum stem extracts have been profiled, even though the roots are also used as herbal remedies. As root extracts may be another source of pharmaceutical compounds, the CH 2 Cl 2/MeOH (1: 1) root bark extract was studied in this report. Eight root bark compounds were isolated and their structural identities were confirmed by mass spectrometry (MS) and nuclear magnetic resonance (NMR)(using COSY, HSQC, NOESY and HMBC) analyses. The structural identities were determined as follows: the fatty acid—myristic acid (1); the sterol—stigmasterol (2); the lignan—sesamin (3); two β-carboline alkaloids—10-methoxycanthin-6-one (6) and canthin-6-one (7); and three phenanthridine alkaloids—8-acetonyldihydrochelerythrine (4), arnottianamide (5) and 8-oxochelerythrine (8). Some of these compounds were identified in the species for the first time. These compounds and the extract were then tested in vitro against methicillin-resistant Staphylococcus aureus (MRSA), Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 29213) and Candida albicans (ATCC 10231) before tests for antiproliferative activity against the human breast cancer (HCC 1395), human prostate cancer (DU 145) and normal (Vero E6) cell lines were conducted. Minimum inhibition concentration values of 3.91, 1.95, 0.98 and 7.81 µg/mL against MRSA, S. aureus, E. coli and C. albicans, respectively, were recorded. Among the isolates, canthin-6-one was the …

Omole RA, Moshi MJ, Ilias M, Larry W, Malebo HM, Omosa LK, Midiwo JO. "In vitro Antiplasmodial and Cytotoxic activity of Three Medicinal Plants used Traditionally for Treatment of Malaria." Investigational Medicinal Chemistry & Pharmacology. 2020;10(1):2-6.omole_et_al_2020.pdf
Omole RA, Moshi MJ, Ilias M, Larry W, Malebo HM, Omosa LK, Midiwo JO. "In vitro Antiplasmodial and Cytotoxic activity of Three Medicinal Plants used Traditionally for Treatment of Malaria." Pharmacognosy Communications. 2020;10(1):2-6. AbstractPharmacognosy Communications

Description
Introduction:
Reports of emergence of Artemisinin Combination Therapies (ACTs) resistant malaria parasites in Greater Mekong region and Equatorial Guinea, is a strong reason necessitating increased efforts to discover new antimalarial compounds with novel mechanisms of action. Plants have potential to yield new antiplasmodial compounds. This study investigated the safety and efficacy of three plants; Bersama abyssinica Fresen, Rubus keniensis Standl and Hypoestes verticillaris (Lf) Sol. ex Roem. and Schult that are used by the Ogiek community of Kenya for treatment of malaria.
Methodology:
The crude extracts were tested for in vitro antimalarial activity using Plasmodium falciparum strains W2 (chloroquine resistant) and D6 (chloroquine sensitive). Safety evaluation was done using monkey kidney Vero cells and the brine shrimp lethality test.
Results:
Dichloromethane: methanol (1: 1) and 5% aqueous methanol extracts of the three plants exhibited in vitro antiplasmodial activity against the W2 and D6 Plasmodium falciparum strains with IC50= 12.11–19.18 µg/mL, 5.46-7.04 µg/mL and 9.82–34.52 µg/mL, respectively. H. verticillaris extracts were the most active against the two Plasmodium falciparum strains. The dichloromethane: methanol extracts of the three plants exhibited lower toxicity on monkey kidney Vero cells relative to antiplasmodial activity as compared to the 5% aqueous methanol extracts. The mean Vero cells: parasite selectivity index of the dichloromethane: methanol extracts was (4.8), B. abyssinica (3.75) and R. keniensis (1.9), while for the 5% aqueous methanol extracts they were H. verticillaris (1.0), B. abyssinica (1.95 …

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