Prevalence and Magnitude of Human Immunodeficiency Virus (HIV) Type 1-Specific Lymphocyte Responses in Breast Milk from HIV-1-Seropositive Women. J Infect Dis. 2003 Dec 1;188(11):1666-74. Lohman BL, Slyker J,Mbori-Ngacha D, Bosire R, Farquhar C, Obimbo E,

Citation:
MBORI- PROFNGACHADOROTHYA, ELIZABETH DROBIMBO. "Prevalence and Magnitude of Human Immunodeficiency Virus (HIV) Type 1-Specific Lymphocyte Responses in Breast Milk from HIV-1-Seropositive Women. J Infect Dis. 2003 Dec 1;188(11):1666-74. Lohman BL, Slyker J,Mbori-Ngacha D, Bosire R, Farquhar C, Obimbo E,.". In: J Infect Dis. 2003 Dec 1;188(11):1666-74. Earthscan, London. 978-1-84407-469-3 (*); 2003.

Abstract:

Department of Medicine, University of Washington, Seattle, Washington 98104, USA. cfarq@u.washington.edu Human leukocyte antigen (HLA) molecules regulate the cellular immune system and may be determinants of infant susceptibility to human immunodeficiency virus type 1 (HIV-1) infection. Molecular HLA typing for class I alleles was performed on infants followed in a Kenyan perinatal cohort. Early HIV-1 infection status was defined as infection occurring at birth or month 1, while late infection via breast milk was defined as first detection of HIV-1 after 1 month of age. Likelihood ratio tests based on a proportional hazards model adjusting for maternal CD4 T cell count and HIV-1 viral load at 32 weeks of gestation were used to test associations between infant allelic variation and incident HIV-1 infection. Among 433 infants, 76 (18%) were HIV-1 infected during 12 months of follow-up. HLA B*18 was associated with a significantly lower risk of early HIV-1 transmission [relative risk (RR) = 0.26; 95% confidence interval (CI) 0.04-0.82], and none of the 24 breastfeeding infants expressing HLA B*18 who were uninfected at month 1 acquired HIV-1 late via breast milk. We observed a trend toward increased early HIV-1 acquisition for infants presenting HLA A*29 (RR = 2.0; 95% CI 1.0-3.8) and increased late HIV-1 acquisition via breast milk for both Cw*07 and Cw*08 (RR = 4.0; 95% CI 1.0-17.8 and RR = 7.2; 95% CI 1.2-37.3, respectively). HLA B*18 may protect breast-feeding infants against both early and late HIV-1 acquisition, a finding that could have implications for the design and monitoring of HIV-1 vaccines targeting cellular immune responses against HIV-1. PMID: 15307911 [PubMed - indexed for MEDLINE]

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