Bio

Dr. Diana Marangu MBChB, MMed, MPH, MPhil, PhD

Diana is a Consultant Paediatric Pulmonologist and Lecturer in the Department of Paediatrics and Child Health. She is passionate about improving respiratory health in children, nationally, regionally and globally.

Publications


2019

Katz, MA, Marangu D, Attia EF, Bauwens J, Bont LJ, Bulatovic A, Crane J, Doroshenko A, Ebruke BE, Edwards KM, Fortuna L, Jagelaviciene A, Joshi J, Kemp J, Kovacs S, Lambach P, Lewis KDC, Ortiz JR, Simões EAF, Turner P, Tagbo BN, Vaishnavi V, Bonhoeffer J.  2019.  Acute wheeze in the pediatric population: Case definition & guidelines for data collection, analysis, and presentation of immunization safety data., 2019 01 07. Vaccine. 37(2):392-399.
Marangu, D, Gray D, Vanker A, Zampoli M.  2019.  Exogenous lipoid pneumonia in children: A systematic review., 2019 Jan 20. Paediatric respiratory reviews. Abstract

To describe the clinical-radiological-pathological characteristics and treatment outcomes of children with suspected exogenous lipoid pneumonia (ELP).

2018

Andreieva, IO, Konstantynovska O, Midulla F, Marangu D, Mchedlishvili N.  2018.  Summer schools of adult and paediatric respiratory medicine: course report., 2018 Mar. Breathe (Sheffield, England). 14(1):9-12. Abstract
Marangu, D, Pillay K, Banderker E, Gray D, Vanker A, Zampoli M.  2018.  Exogenous lipoid pneumonia: an important cause of interstitial lung disease in infants., 2018 Oct. Respirology case reports. 6(7):e00356. Abstract

Exogenous lipoid pneumonia (ELP), an important cause of interstitial lung disease, often goes unrecognized. We conducted a retrospective study of children with histologically confirmed ELP at Red Cross Children's Hospital, South Africa. Twelve children of Zimbabwean heritage aged 2.1-10.8 months were identified between 2012 and 2017. Repeated oral administration of plant-based oil for cultural reasons was reported by 10 of 11 caregivers. Cough (12/12), tachypnoea (11/12), hypoxia (9/12), and diffuse alveolar infiltrates on chest radiography (12/12) were common at presentation. Chest computed tomography revealed ground-glass opacification with lower zone predominance (9/9) and interlobular septal thickening (8/9). Bronchoalveolar lavage specimens appeared cloudy/milky, with abundant lipid-laden macrophages and extracellular lipid on Oil-Red-O staining (12/12), with polymicrobial (6/12) and Mycobacterium abscessus (2/12) co-infection. Antibiotics, systemic corticosteroids, and therapeutic lavage were interventions in all eight and five patients, respectively. Clinicians should consider ELP in children with non-resolving pneumonia in settings with similar practices.

2017

Marangu, D, Mwaniki H, Nduku S, Maleche-Obimbo E, Jaoko W, Babigumira J, John-Stewart G, Rao D.  2017.  Stakeholder perspectives for optimization of tuberculosis contact investigation in a high-burden setting., 2017. PloS one. 12(9):e0183749. Abstract

Optimal tuberculosis contact investigation impacts TB prevention, timely case finding and linkage to care, however data on routine implementation in high burden contexts is limited.

Marangu, D, Mwaniki H, Nduku S, Maleche-Obimbo E, Jaoko W, Babigumira J, John-Stewart G, Rao D.  2017.  ADAPTING A STIGMA SCALE FOR ASSESSMENT OF TUBERCULOSIS-RELATED STIGMA AMONG ENGLISH/SWAHILI-SPEAKING PATIENTS IN AN AFRICAN SETTING., 2017 Nov. Stigma and health. 2(4):326. Abstract

To adapt a validated instrument that quantitatively measures stigma among English/Swahili speaking TB (tuberculosis) patients in Kenya, a high burden TB country.

2016

Russ, CM, Ganapathi L, Marangu D, Silverman M, Kija E, Bakeera-Kitaka S, Laving A.  2016.  Perspectives of host faculty and trainees on international visiting faculty to paediatric academic departments in East Africa., 2016. BMJ global health. 1(3):e000097. Abstract

Investments in faculty exchanges to build physician workforce capacity are increasing. Little attention has been paid to the expectations of host institution faculty and trainees. This prospective qualitative research study explored faculty and resident perspectives about guest faculty in paediatric departments in East Africa, asking (1) What are the benefits and challenges of hosting guest faculty, (2) What factors influence the effectiveness of faculty visits and (3) How do host institutions prepare for faculty visits?

2015

Marangu, D, Devine B, John-Stewart G.  2015.  Diagnostic accuracy of nucleic acid amplification tests in urine for pulmonary tuberculosis: a meta-analysis., 2015 Nov. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease. 19(11):1339-47. Abstract

To determine the diagnostic accuracy of tuberculosis (TB) nucleic acid amplification tests (NAATs) in urine samples for individuals with active pulmonary tuberculosis (PTB).

Marangu, D, Kovacs S, Walson J, Bonhoeffer J, Ortiz JR, John-Stewart G, Horne DJ.  2015.  Wheeze as an adverse event in pediatric vaccine and drug randomized controlled trials: A systematic review., 2015 Oct 5. Vaccine. 33(41):5333-41. Abstract

Wheeze is an important sign indicating a potentially severe adverse event in vaccine and drug trials, particularly in children. However, there are currently no consensus definitions of wheeze or associated respiratory compromise in randomized controlled trials (RCTs).

2014

Marangu, D, Jowi C, Aswani J, Wambani S, Ruth Nduati.  2014.  Prevalence and associated factors of pulmonary hypertension in Kenyan children with adenoid or adenotonsillar hypertrophy., 2014 Aug. International journal of pediatric otorhinolaryngology. 78(8):1381-6. Abstract

Adenotonsillar hypertrophy is a common condition in childhood, whose serious complications of pulmonary hypertension and cor pulmonale are devastating but local prevalence is unknown. This study determined the prevalence and associated factors of pulmonary hypertension in children with adenoid or adenotonsillar hypertrophy at Kenyatta National Hospital, Kenya.

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