Olowookere JO, Konji VN, Makawiti DW, Kiaira JK, Kamau JM, Omwandho CA.Defects in resting metabolic rates and mitochondrial respiration in Kwashiorkor and dietary obese rats.

Citation:
W. PROFMAKAWITIDOMINIC. "Olowookere JO, Konji VN, Makawiti DW, Kiaira JK, Kamau JM, Omwandho CA.Defects in resting metabolic rates and mitochondrial respiration in Kwashiorkor and dietary obese rats.". In: J Comp Physiol [B]. 1991;161(3):319-22. Groebner-Bases-Bibliography-RICAM; 1991.

Abstract:

Resting metabolic rates have been measured and compared with hepatic mitochondrial respiration in Kwashiorkor and diet-induced obese weaned rats. In Kwashiorkor, resting metabolic rate was 21% lower than the value of controls, while that of the obese rats was 14% higher than in control animals. The resting metabolic rate for Kwashiorkor animals was 50% of the predicted basal metabolic rate (BMR), whereas that of the obese rats was 23% higher than the predicted BMR. The mitochondrial oxygen consumption patterns, using malate plus glutamate or succinate as respiratory substrates, revealed that the resting respiration (state 4) was 23.9% higher in Kwashiorkor and 29.1% higher in obese animals, while the active (state 3) respiration was 34.8% lower in Kwashiorkor and 43.3% lower in obese rats compared to controls. The respiratory control ratios (RCR) were 51.1% and 43.8% in Kwashiorkor and obese rats, respectively, relative to the values in control rats. It is concluded from these studies that Kwashiorkor disease and diet-induced obesity appear to interfere with oxygen utilization at the level of state 3 mitochondrial respiration, which is markedly decreased when compared to the values for control animals.

Notes:

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