Lomo PO, Makawiti DW, Konji VN.Respiratory activity of isolated liver Mitochondria following Trypanosoma congolense infection in rabbits: the role of thyroxine. Comp Biochem Physiol B. 1993 Jan;104(1):187-91.

Citation:
W. PROFMAKAWITIDOMINIC. "Lomo PO, Makawiti DW, Konji VN.Respiratory activity of isolated liver Mitochondria following Trypanosoma congolense infection in rabbits: the role of thyroxine. Comp Biochem Physiol B. 1993 Jan;104(1):187-91.". In: Comp Biochem Physiol B. 1993 Jan;104(1):187-91. Groebner-Bases-Bibliography-RICAM; 1993.

Abstract:

The effect of trypanosome infection on rabbit liver mitochondrial oxidative phosphorylation was investigated, with and without thyroxine replacement. 2. State 3 respiration, respiratory control ratio (RCR) and ADP/O ratio were significantly reduced in mitochondria from trypanosome-infected animals whereas there was no change in state 4 respiration. 3. State 3 respiration, RCR and ADP/O ratio were not significantly altered in trypanosome-infected animals given thyroxine replacement therapy. 4. Trypanosome infection leads to impairment of mitochondrial integrity, apparently through lowered thyroxine levels. Replacement of thyroxine therefore sustains optimal mitochondrial respiratory activity.

Notes:

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