Mogoa, E.G.M., Mbithi, P.M.F., Nguhiu, J.M. and Kihurani, D.O. (2001):Alpha-2-Adrenoceptor agonists in Veterinary practice. The Kenya Veterinarian, 22: 82-90.

Citation:
O. PROFKIHURANIDAVID. "Mogoa, E.G.M., Mbithi, P.M.F., Nguhiu, J.M. and Kihurani, D.O. (2001):Alpha-2-Adrenoceptor agonists in Veterinary practice. The Kenya Veterinarian, 22: 82-90.". In: Proceedings of the First Scientific Symposium of the European College of Equine Internal Medicine. In Tierarztliche Praxis, 32; 80-81. Philosophical Issues Invoked by Shona People; 2001.

Abstract:

Yohimbine, 4-aminopyridine, and a combination of the 2 drugs were studied to asses their potential as antagonists to xylazine in goats. Twenty-four shall East African goats were divided randomly into 4 groups of 6 goats each in a placebo-controlled study. They were all treated with intramuscular xylazine at 0.44 mg/kg. At the time of maximum sedation, sterile water was administered intravenously to the control group, 0.15 % 40aminopyridine at 0.4mg/kg to Group2, 0.1% yohimbine at 0.25mg/kg to Group 4. The hohimbine/40aminopyridine combination was also used to antangonise xylazine at 0.88mg/kg in 6 goats. The heart rate, respiratory rate and rate of ruminal movements, the peal and palpebral reflexes as well as the reaction to noxious stimuli, the standing time and the total recovery time were established and evaluated to assess the effects of the treatments. The drugs reversed the xylazine-induced decrease in the heart rate, respiratory rate and rate of ruminal movements and also rapidly restored the reflexes as well as the reaction to noxious stimulation. In addition, they significantly (p<0.05) decreased the mean standing time. The mean total recovery time was decreased significantly (p<0.05) by 4-aminopyridine and the yohimbine/4-aminopyridine combination, but non-sigificantly (p>0.05) by yohimbine. No relapse in sedation occurred. Overall, the combination of yohimbine and 4-aminopyridine produce better responses than the individual drugs, and may therefore be used for rapid reversal of xylazine-induced sedation in goats. Yohimbine or 4-aminopyridine may also be useful for this purpose but recovery may be prolonged. Key words: small East African goats, xylazine antagonists, xylazine hydrochloride, yombine, 4-aminopyridine.

Notes:

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