A survey was carried out during the 2009/10 season to examine the vulnerability of agro-pastoral communities to drought shocks in Bobonong and Kgalagadi North Sub-districts. The key drivers of vulnerability of households included: gender of the household head, livestock sales, advance preparations before drought, size of arable land under cultivation, the number of drought-tolerant crops planted, as well as, the overall yield of such crops. Although the main determinants of household vulnerability differed between the two study areas, Bobonong nonetheless had a higher percentage of highly vulnerable households. However, the two study areas still had a substantial number of vulnerable households – further underlining the seriousness of drought risk among agro-pastoralists in Botswana. Thus, timing and form of intervention, including from the government, is critical and a one-size-fits-all approach to alleviating adverse impacts of drought may not always be appropriate.