Bio

My bio

The only thing I had in abundance growing up was access to all manner of books -- my father was a strict educationist. I studied at Geteri Primary School and Kisii School prior to joining the University of Nairobi in October 1999 to study for a BPharm degree. I successfully completed my undergraduate studies in 2003, went through a one-year internship and got registered as a pharmacist in 2005.

Publications


2015

Ongarora, DSB, Strydom N, Wicht K, Njoroge M, Wiesner L, Egan TJ, Wittlin S, Jurva U, Masimirembwa CM, Chibale K.  2015.  Antimalarial benzoheterocyclic 4-aminoquinolines: Structure-activity relationship, in vivo evaluation, mechanistic and bioactivation studies., 2015 Sep 1. Bioorganic & medicinal chemistry. 23(17):5419-32. Abstract

A novel class of benzoheterocyclic analogues of amodiaquine designed to avoid toxic reactive metabolite formation was synthesized and evaluated for antiplasmodial activity against K1 (multidrug resistant) and NF54 (sensitive) strains of the malaria parasite Plasmodium falciparum. Structure-activity relationship studies led to the identification of highly promising analogues, the most potent of which had IC50s in the nanomolar range against both strains. The compounds further demonstrated good in vitro microsomal metabolic stability while those subjected to in vivo pharmacokinetic studies had desirable pharmacokinetic profiles. In vivo antimalarial efficacy in Plasmodium berghei infected mice was evaluated for four compounds, all of which showed good activity following oral administration. In particular, compound 19 completely cured treated mice at a low multiple dose of 4×10mg/kg. Mechanistic and bioactivation studies suggest hemozoin formation inhibition and a low likelihood of forming quinone-imine reactive metabolites, respectively.

2014

Njoroge, M, Njuguna NM, Mutai P, Ongarora DSB, Smith PW, Chibale K.  2014.  Recent Approaches to Chemical Discovery and Development Against Malaria and the Neglected Tropical Diseases Human African Trypanosomiasis and Schistosomiasis., 2014 Jul 11. Chemical reviews. 114(22):11138-11163.
Cruickshank, DL, Y. Y, Njuguna NM, Ongarora DSB, Chibale K, Caira MR.  2014.  Alternative solid-state forms of a potent antimalarial aminopyridine: X-ray crystallographic, thermal and solubility aspects.. CrystEngComm. 16:5781-5792.

2012

Njuguna, NM, Ongarora DSB, Chibale K.  2012.  Artemisinin derivatives: a patent review (2006 - present).. Expert Opinion on Therapeutic Patents. 22(10):1179-1203.
Ongarora, DSB, Masimirembwa CM, Chibale. K.  2012.  Towards safer 4- aminoquinoline antimalarials: design, synthesis and evaluation of novel analogues of amodiaquine.. Molecular Approaches to Malaria Conference. , Lorne, Australia
Ongarora, DSB, Gut J, Rosenthal PJ, Masimirembwa CM.  2012.  Benzoheterocyclic amodiaquine analogues with potent antiplasmodial activity: Synthesis and pharmacological evaluation.. Bioorg. Med. Chem. Lett. . 22(15):5046-5050.

2009

Ongarora, DSB, Thoithi GN, Kamau FN, Abuga KO, Mwangi JW, Kibwage IO.  2009.  Triterpenoids from the stem bark of Blighia unijugata Bak (Sapindaceae). Ethiop. Pharm. J. . 24:71-74.

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