| PROF. GATEI DAVID G

Bio

Prof. David Gatei

Date of Birth : April 1941

Nationality : Kenyan

Marital Status : Married

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(Last updated: April 8, 2013)

Publications

Submitted

G, PROFGATEIDAVID. Submitted. J E Sanderson, E G Olsen, and D Gatei.Peripartum heart disease: an endomyocardial biopsy study.. Br Heart J. 56(3): 285. : RIVERBRROKS COMMUNICATIONS Abstract

Endomyocardial biopsies were performed in 11 African women in Nairobi who presented with the clinical features of peripartum cardiomyopathy. The samples were studied by light and electron microscopy. In five patients there was evidence of a "healing myocarditis", that is the presence of a mild inflammatory cell infiltration within the myocardium with foci of necrosis and variable amounts of hypertrophy and fibrosis. Of the nine patients who were followed up, three out of four with myocarditis had persistent heart failure and four out of five without myocarditis improved. Peripheral blood T lymphocyte cell subsets were measured in nine patients by means of monoclonal antibodies. A high helper:suppressor T cell ratio was found in three patients. Almost half of this group of patients with peripartum cardiomyopathy had myocarditis in their biopsy specimens. The myocarditis may have been due to an inappropriate immunological reaction in some patients.

2009

Greenfield, C, Shah MV, Okoth F, Gatei D, Jowett T, Karayannis P, Wankya BM. 2009. Serological evidence of hepatitis B virus and hepatitis delta virus infection in 164 patients with histological evidence of liver damage.

1993

WANJIRU, DRMWANGIJANE, G PROFGATEIDAVID. 1993. Hepatitis B virus, hepatocellular carcinoma and liver cirrhosis in Kenya. East Afr Med J. 1993 Apr;70(4 Suppl):34-6.. East Afr Med J. 1993 Apr;70(4 Suppl):34-6.. : RIVERBRROKS COMMUNICATIONS Abstract

Hepatocellular carcinoma is the third most common malignancy in Kenyan males occurring with a peak incidence at 40 years of age. A worldwide correlation has been noted between the incidence of hepatocellular carcinoma and prevalence of hepatitis B virus. Liver biopsies with histological diagnosis of hepatocellular carcinoma (HCC), cirrhosis and the normals were reviewed by the authors. They were then stained for hepatitis B surface antigen (HBsAg) and hepatitis e core antigen (HBcAg). Only 2.5% of normal livers were positive for HBsAg compared with 33% of HCC and 25% of cirrhosis respectively. Hepatitis core antigen was not demonstrated in normal liver biopsies but it was present in 11.5% of HCC and 14% of cirrhosis. Background cirrhosis was noted in 52% of biopsies showing HCC. It is clear that a causal association exists between hepatitis B virus (HBV) and both liver cirrhosis and hepatocellular carcinoma. Higher antigen markers, up to 80% have been reported in South East Asia and India. This difference may be due to the type of biopsy examined (needle biopsy vs open biopsy) but the possibility that other factors such as aflatoxin and non A/non B hepatitis viruses play a more significant role in the causation of liver disease in Kenya than has previously been assumed should be explored.

1992

Bjerregaard, B, Okoth-Olende CA, Gatei D, Bal IS, Jensen H. 1992. Tumours of the nose and maxillary sinus. Ten year survey from Kenya. Abstract

Between 1976-1985, 127 cases of malignant tumours of the nose and maxillary sinus were seen at the Department of Human Pathology, Kenyatta National Hospital, Nairobi, Kenya. Cancer of the nose and maxillary sinus was a common diagnosis accounting for 0.8 per cent of all malignancies. Despite this, the incidence was low probably because the rural Kenyans have difficulty in gaining access to the oncology facilities in Nairobi. Incidence rates standardized to world population per 100,000 persons-years were 0.16 for males and 0.12 for females. Clinical information showed that malignancy should be expected in patients with swelling of the cheek and involvement of the orbit. Compared with Denmark the proportion of undifferentiated carcinomas was significantly higher in Kenya. The well known fact that anaplastic carcinoma of the postnasal space is causally associated with the Epstein Barr virus makes it tempting to suggest that anaplastic carcinoma of the nose and maxillary sinus may also be of viral aetiology.

1987

Okoth, F, Ogutu EO, LULE GN, Were JBO, Gatei D, Kinoti SN. 1987. Upper Gastrointestinal Tract Endoscopic findings in 709 Africans Patients Endoscoped at KEMRI – May 1987.

1986

Okoth, FA, Bowry TR, Shah MV, Gatei DG. 1986. Aetiology of liver cirrhosis in Kenya. Website

G, PROFGATEIDAVID. 1986. Aetiology of liver cirrhosis in Kenya. East Afr Med J. 1986 Nov;63(11):724-30.. Br Heart J. 56(3): 285. : RIVERBRROKS COMMUNICATIONS Abstract

No abstract available.

1983

G, PROFGATEIDAVID. 1983. Muigai R, Gatei DG, Shaunak S, Wozniak A, Bryceson AD. Jejunal function and pathology in visceral Leishmaniasis. Lancet. 1983 Aug 27;2(8348):476-9.. Lancet. 1983 Aug 27;2(8348):476-9.. : RIVERBRROKS COMMUNICATIONS Abstract

Small-intestinal function was studied in 10 patients with visceral leishmaniasis. Vitamin-A absorption was impaired in 7 and d-xylose in 1. In 5 of the 10 patients Leishmania were demonstrated in biopsy specimens of intestinal mucosa. Parasitised macrophages were present in villous tips and less commonly in the lamina propria and submucosa; a moderate inflammatory infiltrate was composed of lymphocytes and plasma cells. 2 patients had partial villous atrophy. There was no correlation between intensity of parasitisation and severity of malabsorption. After treatment with sodium stibogluconate there was a significant improvement in absorption of vitamin A and d-xylose, and biopsy specimens became normal. In 1 patient visceral leishmaniasis was thought to be the cause of chronic diarrhoea.

1982

G, PROFGATEIDAVID. 1982. Rees PH, Gatei DG, de Cock KM, Tosswill J. Some preliminary observations on the investigation of splenomegaly in Kenya. East Afr Med J. 1982 Oct;59(10):658-64. No abstract available.. East Afr Med J. 1982 Oct;59(10):658-64. No abstract available.. : RIVERBRROKS COMMUNICATIONS Abstract

1981

G, PROFGATEIDAVID. 1981. Kaposi's sarcoma in Kenya: a retrospective clinicopathological study. Antibiot Chemother. 1981;29:38-58. East Afr Med J. 1981 Sep;58(9):636-40. No abstract available.. : RIVERBRROKS COMMUNICATIONS Abstract

No abstract available.

G, PROFGATEIDAVID. 1981. De Cock KM, Gatei DG, Shah MV. Aspiration cytology in the diagnosis of liver cancer. East Afr Med J. 1981 Sep;58(9):636-40. No abstract available.. East Afr Med J. 1981 Sep;58(9):636-40. No abstract available.. : RIVERBRROKS COMMUNICATIONS Abstract

1979

G, PROFGATEIDAVID. 1979. Upper gastrointestinal endoscopic experience at Kenyatta National Hospital. East Afr Med J. 1979 Dec;56(12):675-80. No abstract available. PMID: 544267 [PubMed - indexed for MEDLINE]. East Afr Med J. 1979 Dec;56(12):675-80.. : RIVERBRROKS COMMUNICATIONS Abstract

No abstract available.

G, PROFGATEIDAVID. 1979. Recruitment and training of pathologists in Kenya.. East Afr Med J. 1979 Nov;56(11):537-9.. : RIVERBRROKS COMMUNICATIONS Abstract

No abstract available.

1978

G, PROFGATEIDAVID. 1978. Kaminsky RG, Gatei DG, Zimmermann RR. Human coenurosis from Kenya. East Afr Med J. 1978 Aug;55(8):355-9.. East Afr Med J. 1978 Aug;55(8):355-9.. : RIVERBRROKS COMMUNICATIONS Abstract

A clinical, radiological, histological, and geographical study of carcinoma of the esophagus in Kenya is reported. It was found that this cancer is diagnosed more often in males than in females, with a ration of 8:1 (Kenya Cancer Registry). The most common age in males and females is 50 to 59 years. The regions of the esophagus most commonly involved are the middle and lower thirds, in almost equal proportions. An unexplained tendency for the tumor to be poorly differentiated towards the lower third is noted. In addition a review on the possible etiological factors is presented.

G, PROFGATEIDAVID, O PROFORINDADA, G PROFGATEIDAVID. 1978. Gatei DG, Odhiambo PA, Orinda DA, Muruka FJ, Wasunna A. Retrospective study of carcinoma of the esophagus in Kenya. Cancer Res. 1978 Feb;38(2):303-7.. Cancer Res. 1978 Feb;38(2):303-7.. : RIVERBRROKS COMMUNICATIONS Abstract

A., PROFODHIAMBOPETER, G PROFGATEIDAVID, O PROFORINDADA. 1978. Retrospective Study of Cancer of the Esophagus in Kenya. Cancer Research, 38: 303 - 305. : RIVERBRROKS COMMUNICATIONS Abstract

Retrospective Sturdy of Cancer of the Esophagus in Kenya - Cancer Research, 38: 303 - 305, February 1978. (Second of five authors - D.G. Gatei, A.E.O. Wasunna, D.A. Orinda and J. Muruka).