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Owakah F, Warambo KA. "Negotiating a place and space for Ethics in the Conservation of Kenya’s Heritage: Thinking philosophically and strategizing sociologically.". In: 2nd Annual Nairobi International Multidisciplinary . Nairobi; Forthcoming.
Geyer. S and Wairire GG, Lombard A, Wairire GG. "A comparative content analysis of South African and Kenyan drug policies from a social development perspective." The Social Work Practitioner-Researcher. Forthcoming.
and Wairire GG, Muiruri J. "Handbook of Social Work and Social Development Practice in Africa.". In: Afrocentric strengths-based community work practice: The case of vyamas in Kenya . Ashgate Publishing Ltd; Forthcoming.
MONARI FRONICA, Wakoli P. "Internet Access, Uses and Gratifications among University Students: A Survey of the School of Journalism and Mass Communication.". In: African International Business and Mnagement (AIBUMA). Nairobi, Kenya; Forthcoming.
Wambui K, Muiru N, Amatsimbi M. "The Kenya Media: A Brief History.". In: Voices of Media Veterans: Reflections over 70 Years on Communication and Media in Kenya . Nairobi: University of Nairobi & Ford Foundation; Forthcoming.
IRIBEMWANGI PI, Nyaga L, Warambo JP. Kiswahili Pevu: Isimu, Muundo na Sarufi .; Forthcoming.
Amatsimbi M, Wambui K. "Media Veterans in Kenya: Archival Records.". In: Voices of Media Veterans: Reflections over 70 Years on Communication and Media in Kenya . University of Nairobi & Ford Foundation; Forthcoming.
Ngugi M, Wambui K. "Media, Memory, History and the Evolution of Free Expression in Kenya.". In: Voices of Media Veterans: Reflections on 70 Years of Communication and Media in Kenya. Nairobi: University of Nairobi; Forthcoming.
Bailasha NK, Nteere JS, Rintaugu EG, Wanderi PM. Motivation orientation in sports - A study of athletes in Kenya .; Forthcoming.
With McCormick D, Chitere P, Orero R, Ommeh M. "Paratransit Business Strategies : A Bird’s Eye View of Matatu in Nairobi’ ." Journal of Public Transport. Forthcoming.
Wasamba P, Situma J. "Problematics of Plato's Aesthetic Theory in Contemporary Society." The Nairobi Journal of Literature. Forthcoming.
Kiplagat D. STRATEGY FOR THE IMPLEMENTATION AND ADOPTION OF E-PROCUREMENT IN KENYA PUBLIC SECTOR. Wausi D, ed. Nairobi: University of Nairobi; Forthcoming. Abstract

There is strong consensus among researchers and practitioners regarding the strategic importance of developing efficient purchasing techniques to increase transparency and fairness, reduce corruption, ensure competitiveness and reduce costs. An increasing number of government authorities are adopting e-procurement solutions to reap the above stated benefits (Panayiotou et al., 2004). E-procurement is the process of purchasing goods and services electronically , and can be defined as “the use of integrated (commonly web-based) communication systems for the conduct of part or all of the purchasing process; a process that may incorporate stages from the initial need identification by users, through search, sourcing, negotiation, ordering, receipt, payment and post-purchase review” (Presutti,2003).

In this research proposal I propose to comprehensively study through explorative case study five successful cases of e-procurement in the public sector in Korea, Australia, Italy, Ireland, Philippine's and use their experiences, challenges and strategies employed to come up with a multi-disciplinary framework for the successful implementation and adoption of e-procurement in the public sector in Kenya. In this research critical successes factors (CSFs) and diffusion of innovation theory will be used in the study. Explorative case study and qualitative research design methodology will be used in this research study although aspects on the attitude of the intended users will be analyzed quantitatively.

W. MK. "Indigenous Languages, Performing Arts and the HIV/ Aids Pandemic." Hekima: Journal of Humanities and Social Sciences, Vol. III. No. ?; Forthcoming. Abstract
Wazid AM, Anyenda OE, Tole NM. "Eye Lens and Thyroid gland dose during CT head scanning in Kenyatta National Hospital, Kenya." South Africa Journal of Radiology. Submitted.
MBORI- PROFNGACHADOROTHYA, W. PROFNDUATIRUTH, ELIZABETH DROBIMBO. "HIV-1 Disease Progression in Breast-Feeding and Formula-Feeding Mothers: A Prospective 2-Year Comparison of T Cell Subsets, HIV-1 RNA Levels, and Mortality. Otieno PA, Brown ER, Mbori-Ngacha DA, Nduati RW, Farquhar C, Obimbo EM, Bosire RK, Emery S, Overba.". In: J Infect Dis. 2007 Jan 15;195(2):220-9. Epub 2006 Dec 13. Earthscan, London. 978-1-84407-469-3 (*); Submitted. Abstracthiv.pdf

Centre for Clinical Research, Kenya Medical Research Institute, University of Nairobi, Nairobi, Kenya. Background. There is conflicting evidence regarding the effects of breast-feeding on maternal mortality from human immunodeficiency virus type 1 (HIV-1) infection, and little is known about the effects of breast-feeding on markers of HIV-1 disease progression.Methods. HIV-1-seropositive women were enrolled during pregnancy and received short-course zidovudine. HIV-1 RNA levels and CD4 cell counts were determined at baseline and at months 1, 3, 6, 12, 18, and 24 postpartum and were compared between breast-feeding and formula-feeding mothers.Results. Of 296 women, 98 formula fed and 198 breast-fed. At baseline, formula-feeding women had a higher education level and prevalence of HIV-1-related illness than did breast-feeding women; however, the groups did not differ with respect to CD4 cell counts and HIV-1 RNA levels. Between months 1 and 24 postpartum, CD4 cell counts decreased 3.9 cells/ mu L/month (P<.001), HIV-1 RNA levels increased 0.005 log(10) copies/mL/month (P=.03), and body mass index (BMI) decreased 0.03 kg/m(2)/month (P<.001). The rate of CD4 cell count decline was higher in breast-feeding mothers (7.2 cells/ mu L/month) than in mothers who never breast-fed (4.0 cells/ mu L/month) (P=.01). BMI decreased more rapidly in breast-feeding women (P=.04), whereas HIV-1 RNA levels and mortality did not differ significantly between breast-feeding and formula-feeding women.Conclusions. Breast-feeding was associated with significant decreases in CD4 cell counts and BMI. HIV-1 RNA levels and mortality were not increased, suggesting a limited adverse impact of breast-feeding in mothers receiving extended care for HIV-1 infection.

Plasman, M., Tiberi, C., Ebinger, C., Albaric, J., Peyrat, S., Déverchère, J., Le Gall, B., Tarits, P., Roecker, S., Wambura, R. MMAG, Wambura, R. MMAG, Wambura, R. MMAG, Mtelela, K. MKHPGMGS, Msabi, M. KHPGGSJ. "Lithospheric low-velocity zones associated with a magmatic segment of the Tanzanian Rift, East Africa." Geophyscical Journal International. Submitted.
Weinstein, A. EORTALWAGMCSS, Ebinger, C. ORTALWAGMSSC, Oliva, S. RTALWAGMSCM, Roecker, S. TALWAGMCMC, Tiberi, C. ALWAGMMCE, Aman, M. LWAGMCEJ, Lambert, C. WAGMEJS, Witkin, E. AGMJS, Albaric, J. GMS, Gautier, S. M, Muzuka, A. MKHI-KMFPMRGGR, Mulibo, G. KG, Kianji, G., Hadfield, R. I-KMFPMRFMR, Illsley-Kemp, F. MFPMRMRS, Msabi, M. FPMRRSJ, Ferdinand, R. PMRSJ, Peyrat, S. MRJ, Muirhead, J. R, Rodzianko, A., Fischer T. "Magmatic Co2 assisted rifitng in East Africa : seismicity of the Magadi-Natron-Manyara basins, Africa. Submitted to Tectonics." tectonics. Submitted.
Shiundu PM, Munguti SM, Williams KRS. "Practical implications of ionic strength effects on particle retention in thermal field-flow fractionation.". Submitted. AbstractPractical implications of ionic strength effects on particle retention in thermal field-flow fractionation

Modification of ionic strength of an aqueous or non-aqueous carrier solution can have profound effects on the particle retention behavior in thermal field-flow fractionation (ThFFF). These effects can be considered as either advantageous or not depending on the performance criteria under consideration. Aside from the general increase in retention time of particulate material (latexes and silica particles), our experiments indicate improvement in resolution with increases in electrolyte concentration. Absence of an electrolyte in the carrier solution causes deviations from the theoretically expected linear behavior between the retention parameter l (a measure of the extent of interaction between the applied field and the particle) and the reciprocal temperature drop across the channel walls. A negative interaction parameter d of about 20.170 was determined for 0.105- and 0.220-mm polystyrene (PS) latex particles suspended in either a 0.25 or a 1.0 mM TBAPcontaining acetonitrile carrier and for 0.220 mm PS in 0.50 and 1.0 mM NaCl-containing aqueous medium. This work also demonstrates that optimum electrolyte concentrations can be chosen to achieve reasonable experimental run-times, good resolution separations, and shifts in the steric inversion points at lower field strengths, and that too high electrolyte concentrations can have deleterious effects such as band broadening and sample loss through adsorption to the channel accumulation surface. The advantages of using ionic strength rather than field strength to effect desired changes are lowered power consumption and possible application of ThFFF to high temperature-labile samples.

Gripenberg U, Saarinen I, Bwibo NO, Oduori ML, Grayburn JA, Awori NW, Wasunna AE, Kinuthia DM. "Two true hermaphrodites with XX chromosomes.". Submitted.
Obiero JA, Mburu MN, Ndung’u BM, Waititu KK, Farah IO, Mwethera PG. "UniPron is A Fully Effective Non-hormonal Reversible Contraceptive in Baboon Model (Papio Anubis).". Submitted. AbstractWebsite

Objective To determine the safety and efficacy of UniPron as a reversible contraceptive. Methods Vaginal swabs were obtained before and after UniPron administration, cultured onto appropriate culture media and bacteria identification was done based on type of media used, Gram stain reactions, colony morphology and biochemical tests. Vaginal biopsy tissues were processed using paraffin wax method, stained with hematoxylin and eosin and examined under light microscopy to determine the effect of the product on vaginal tissues. The effect of UniPron on sperm was examined by mixing the product with electroejaculated spermatozoa in vitro at different concentrations. For efficacy studies, male baboons of proven fertility were mated with UniPron treated or untreated females of proven fertility during the fertile stages. Results All the five females (100%) that were treated with UniPron did not conceive and they regained total fertility when the treatment was stopped while all the controls conceived. At a concentration of 40%,UniPron completely immobilized spermatozoa in an in-vitro system. UniPron mechanism of action was by lowering the vaginal pH and on application in baboon, the pH was lowered for at least 3 h after which it went back to normal. Conclusions As we plan for a study to test UniPron as a microbicide to prevent STIs including HIV, our current study has established that this novel product is effective in contraception and harmless to vaginal tissues and vaginal microbial flora in a baboon model (Papio anubis).

Aduda BOC, Egbe PDDDAM, Musembi RJ, WAITA SEBASTIAN, Kaduki KA, Simiyu J, Agacho A, Nyongesa F. "ANSOLE Mini-Symposium in Kenya (AMSK 2013).". Submitted. Abstract
Rylander F, Peng B, Wheeler J. "Bike Share Usage Prediction in London.". Submitted. Abstract
WANJIRA DRNJUGUNAPAMELA. "Computerized tomography scan of the brain in a community study of neurological impairment in Kenya. Njuguna PW, Mungala-Odera V, Chong WK, Meehan RA, Newton CR. J Child Neurol. 2007 Jan;22(1):26-32.". In: J Child Neurol. 2007 Jan;22(1):26-32. East African Medical Journal; Submitted. Abstract
Neurological impairment is common in resource-poor countries, but its causes are not clear. Computerized tomography (CT) of the brain has been used to determine the cause of brain insults that may manifest as neurological impairments. The authors conducted a community survey in Kilifi of 10 218 children aged 6 to 9 years to detect neurological impairment. From this survey, 34 children were identified, of whom 16 had motor deficits, 11 complex partial seizures, 4 microcephaly or macrocephaly, and 3 severe developmental delay. These children were assessed with elicitation of history, physical examination, and CT scan of the brain. Sixteen (47%) of the scans showed abnormalities: cerebral atrophy (n = 9), schizencephaly (n = 3), periventricular leukomalacia (n = 2), porencephalic cyst (n = 1), and agenesis of the corpus callosum (n = 1). The minimum prevalence of abnormalities on the CT scan of the brain is 1.56 of 1000, and the prevalence of schizencephaly is 0.29 of 1000. Motor impairments were more likely to show abnormality than the other indications. CT abnormalities are common in children with neurological impairment in Kenya, but the appearances did not identify a major cause.
W PROFNJENGALYDIAH. "Coordination chemistry ( Module II book for open distance learning).". In: (Director, Centre for Open &Distance Learning, University of Nairobi). UoN; Submitted. Abstract
W PROFNJENGALYDIAH. "e-learning module II contents for 'Coordination Chemistry'.". In: A 3rd year BED Science course material. UoN; Submitted. Abstract
Pan J, Utama MIB, Zhang Q, Liu X, Peng B, Wong LM, Sum TC, Wang S, Xiong Q. "for Adv. Mater., DOI: 10.1002/adma. 201104996.". Submitted. Abstract
Maina LG, Maingi N, Nga'Nga C, Waruiru R, Gakuya F, Kanduma E. "Molecular Identity and Phylogeny of Gastrointestinal Strongyle Nematodes in Migratory, Resident, and Sedentary Plains Zebras (Equus Quagga) in Masai Mara National Reserve and Lake Nakuru National Park, Kenya." Resident, and Sedentary Plains Zebras (Equus Quagga) in Masai Mara National Reserve and Lake Nakuru National Park, Kenya. Submitted. Abstract
WARUE MRSKARIUKICATHERINE. "Mr. Nicky Nzioki,Mrs.Catherine Kariuki: An Investigation into the process of Compulsory Acquisition and suggestions on the choice of valuation methodology in making claims for compensation for land for various infrastructure.". In: African Journal of Ecology 46(1):22-29. uon press; Submitted. Abstract
Over the last six years there has been a tremendous development of infrastructure projects in virtually all corners of Kenya. This has taken the form of Road Improvement Project, Water and sewerage improvement project and the Electricity Transmission Improvement Project as envisioned in the Kenya Vision 2030. The purpose of this paper is to investigate the principles of compulsory land acquisition and way leaves in the three sectors in Kenya by looking at the current legislative framework governing the entire process of acquisition. In considering the process, the paper explores the various provisions of the relevant act which governs the particular utility envisaged for improvement project component in the Kenya Vision 2030. A critical evaluation of the procedures adopted is outlined in each case and the general public apprehensions towards such acquisitions. The second part of the paper focuses on suggestions on the choice of valuation methodology in making claims for compensation for land for various infrastructure projects in Kenya. This is borne out of the fact that there appear to be very little standardization in the methods adopted by the various bodies. The paper cites several cases under the Electricity Transmission Improvement Project where a large proportion of way leaves are dealt with at local level, with little consistency. Coupled to this is the public concern that electricity lines have potentially serious health effects that continue to attract research and media interest. The paper concludes with a description of the various cases on how to improve compensation paid to those affected by compulsory acquisition in cases of land and way leaves.
WARUE MRSKARIUKICATHERINE. "Preliminary Suggestions on the implementation of the Land Section of Chapter five of the Constitution of Kenya through Research and Training.". In: African Journal of Ecology 46(1):22-29. uon press; Submitted. Abstract
The New Constitution of Kenya, Chapter five states that land in Kenya will be held, used and managed in a manner that is equitable, efficient, productive and sustainable. The construction also sets out a number of principles, which will be implemented through a national land policy that developed and reviewed regularly by the government and through legislation. The National Land Policy for Kenya is Sessional Paper No. 3 of 2009, it presents the issues and policy recommendations that were identified, analyzed and agreed by stakeholders. The sessional paper forms the foundation upon which administrative and legislative framework will be built. This is the framework that will drive the critically required land reforms for Kenya. This paper gives a detailed outline of the training and capacity building and research requirements in land management and administration. Its main emphasis being the setting up of a Land Policy research Centre in the light of the new institutional framework suggested in chapter 5 of the Constitution of Kenya and the Sessional paper No.3 of 2009. A suitable land policy centre will undertake research and training for the National Land Commission, in the light of the suggested functions. The paper concludes by suggesting the training and research programmes fro governments and individuals in Kenya and within the continent on land.
Peng B, Zhang H, Chen W, Qiu Z-J, Shao H, Zhu H, Monserrat B, Fu D, Weng H. "Ultrafast Photo-induced Phase Transition in 2D MoTe2.". Submitted. Abstract
W DRMAINASUSAN, M DRWAKIAGAJOHN. "Wakiaga J.M., Maina S.W and Kisumbi B.K. Incidence of the Second Canal the Upper Second Premolar. Journal of Dental Research 13th Annual Scientific Conference of the East and Southern Division of IADR.". In: Journal of Dental Research. University of Nairobi Press; Submitted. Abstract
This study was done to determine the nature of utilization of dental auxiliaries and medical emergencies in private dental surgeries in Kenya. A self administering questionnaire with pre-paid postage was mailed to 138 dentists. 27.5% responded. 81.6% used dental auxiliaries and the main reason was to improve efficiency in managing patients. 93.5% of the auxiliaries were on job trained secondary school graduates. 63.2% of the respondents delegated duties which were mainly non-clinical. 26.3% did not delegate any duties. In a descending order, the reasons for non delegation were: that it would be risky to patients, not allowed by law, they did not find it necessary and that auxiliaries were not held responsible if something went wrong. The main duties delegated to the auxiliaries were cleaning of instruments and sterilization, mixing of restorative materials and preparing amalgam. Delegation was done primarily based on auxiliaries capability to perform the procedure and meet the set standards. 57.9% indicated that they rarely encountered medical emergencies. Syncope was the commonest emergency encountered. 72.7% indicated that auxiliaries could not handle medical emergencies because they were not trained. It is concluded that most dentists did not delegate clinical duties to dental auxiliaries and medical emergencies were rare.
In Press
Oloo CM, Onyari JM, Wanyonyi WC, Wabomba JN, Muinde VM. "Adsorptive removal of hazardous crystal violet dye form aqueous solution using Rhizophora mucronata stem-barks: Equilibrium and kinetics studies." Environmental Chemistry and Ecotoxicology. In Press. AbstractEnvironmental Chemistry and Ecotoxicology

Adsorption of crystal violet (CV) dye from aqueous solution using dried bark powder of mangrove species Rhizophora mucronata was studied. Characterization of adsorbent was done using FTIR and SEM. Batch experiment was carried out to examine the viability of using mangrove bark for adsorption of CV dye from aqueous solutions under different process conditions. The result revealed that removal of CV increased with contact time, adsorbent dose, initial dye concentration and decreased with increased particle size and ionic strength. pH 7 was the optimum pH for CV dye removal. The adsorption equilibrium for CV dye by Rhizophora mucronata stem-bark was attained within 60 min with removal efficacy of up to 99.8%. Pseudo-second-order kinetic model was best used to describe sorption kinetics while Freundlich isotherm model was appropriate for describing adsorption isotherm. The results demonstrated …

Wangui J, Nokes JD, Mobegi VA, Otieno JR, Agoti CN, Ngeranwa JJN, Bulimo WD. "Spatial-temporal distribution and sequence diversity of group a human respiratory syncytial viruses in Kenya preceding the emergence of {ON1} genotype." Influenza Other Respi. Viruses. 2022;16:501-510. Abstract

BACKGROUND: Human respiratory syncytial virus (HRSV) is a major cause of severe viral acute respiratory illness and contributes significantly to severe pneumonia cases in Africa. Little is known about its spatial-temporal distribution as defined by its genetic diversity. METHODS: A retrospective study conducted utilizing archived nasopharyngeal specimens from patients attending outpatient clinics in hospitals located in five demographically and climatically distinct regions of Kenya; Coast, Western, Highlands, Eastern and Nairobi. The viral total RNA was extracted and tested using multiplex real time RT-PCR (reverse transcriptase polymerase chain reaction). A segment of the G-gene was amplified using one-step RT-PCR and sequenced by Sanger di-deoxy method. Bayesian analysis of phylogeny was utilized and subsequently median joining methods for haplotype network reconstruction. RESULTS: Three genotypes of HRSVA were detected; GA5 (14.0%), GA2 (33.1%), and NA1 (52.9%). HRSVA prevalence varied by location from 33% to 13.2% in the Highlands and the Eastern regions respectively. The mean nucleotide diversity (Pi[$π$]) varied by genotype: highest of 0.018 for GA5 and lowest of 0.005 for NA1. A total of 58 haplotypes were identified (GA5 10; GA2 20; NA1 28). These haplotypes were introduced into the population locally by single haplotypes and additional subsidiary seeds amongst the GA2 and the NA1 haplotypes. CONCLUSIONS: HRSVA was found across all the regions throughout the study period and comprised three genotypes; GA5, GA2, and NA1 genotypes. The genotypes were disproportionately distributed across the regions with GA5 gradually increasing toward the Western zones and decreasing toward the Eastern zones of the country.

Beydon N, Ferkol T, Harris AL, Colas M, Davis SD, Haarman E, Hogg C, Kilbride E, Kouis P, Kuehni CE, Latzin P, Marangu D, Marthin J, Nielsen KG, Robinson P, Rumman N, Rutter M, Walker W, Lucas JS. "An international survey on nasal nitric oxide measurement practices for the diagnosis of primary ciliary dyskinesia." ERJ Open Res. 2022;8(2). Abstract

Nasal nitric oxide (nNO) measurements are used in the assessment of patients suspected of having primary ciliary dyskinesia (PCD), but recommendations for performing such measurements have not focused on children and do not include all current practices. To guide the development of a European Respiratory Society-supported technical standard for nNO measurement in children, an international online survey was conducted to better understand current measurement practices among providers involved in PCD diagnostics. 78 professionals responded, representing 65 centres across 18 countries, mainly in Europe and North America. Nearly all centres measured nNO in children and more than half performed measurements before 5 years of age. The test was often postponed in children with signs of acute airway infection. In Europe, the electrochemical technique was more frequently used than chemiluminescence. A similar proportion of centres performed measurements during exhalation against a resistance (49 out of 65) or during tidal breathing (50 out of 65); 15 centres used only exhalation against a resistance and 15 used only tidal breathing. The cut-off values used to discriminate PCD were consistent across centres using chemiluminescence analysers; these centres reported results as an output (nL·min). Cut-off values were highly variable across centres using electrochemical devices, and nNO concentrations were typically reported as ppb. This survey is the first to determine real-world use of nNO measurements globally and revealed remarkable variability in methodology, equipment and interpretation. These findings will help standardise methods and training.

Githaka NW, Kanduma EG, Wieland B, Darghouth MA, Bishop RP. "Acaricide resistance in livestock ticks infesting cattle in Africa: Current status and potential mitigation strategies." Curr Res Parasitol Vector Borne Dis. 2022;2:100090. Abstract

In many African countries, tick control has recently been the responsibility of resource-poor farmers rather than central government veterinary departments. This has led to an increase in acaricide resistance, threatening the welfare of livestock farmers in sub-Saharan Africa. Resistance has evolved to the three classes of acaricides used most extensively in the continent, namely fourth-generation synthetic pyrethroids (SP), organophosphates (OP) and amidines (AM), in virtually all countries in which they have been deployed across the globe. Most current data are derived from research in Australia and Latin America, with the majority of studies on acaricide resistance in Africa performed in South Africa. There is also limited recent research from West Africa and Uganda. These studies confirm that acaricide resistance in cattle ticks is a major problem in Africa. Resistance is most frequently directly assayed in ticks using the larval packet test (LPT) that is endorsed by FAO, but such tests require a specialist tick-rearing laboratory and are relatively time consuming. To date they have only been used on a limited scale in Africa and resistance is often still inferred from tick numbers on animals. Rapid tests for resistance in ticks, would be better than the LPT and are theoretically possible to develop. However, these are not yet available. Resistance can be mitigated through integrated control strategies, comprising a combination of methods, including acaricide class rotation or co-formulations, ethnoveterinary practices, vaccination against ticks and modified land management use by cattle, with the goal of minimising the number of acaricide applications required per year. There are data suggesting that small-scale farmers in Africa are often unaware of the chemical differences between different acaricide brands and use these products at concentrations other than those recommended by the manufacturers, or in incorrect rotations or combinations of the different classes of chemicals on the market. There is an urgent need for a more evidence-based approach to acaricide usage in small-scale livestock systems in Africa, including direct measurements of resistance levels, combined with better education of farmers regarding acaricide products and how they should be deployed for control of livestock ticks.

Syvitski J, Ángel JR, Saito Y, Overeem I, Vörösmarty CJ, Wang H, Olago D. "Earth’s sediment cycle during the Anthropocene.". 2022;3(3):179-196. AbstractWebsite

The global sediment cycle is a fundamental feature of the Earth system, balancing competing factors such as orogeny, physical–chemical erosion and human action. In this Review, values of the magnitudes of several sources and sinks within the cycle are suggested, although the record remains fragmented with uncertainties. Between 1950 and 2010, humans have transformed the mobilization, transport and sequestration of sediment, to the point where human action now dominates these fluxes at the global scale. Human activities have increased fluvial sediment delivery by 215% while simultaneously decreasing the amount of fluvial sediment that reaches the ocean by 49%, and societal consumption of sediment over the same period has increased by more than 2,500%. Global warming is also substantially affecting the global sediment cycle through temperature impacts (sediment production and transport, sea ice cover, glacial ice ablation and loss of permafrost), precipitation changes, desertification and wind intensities, forest fire extent and intensity, and acceleration of sea-level rise. With progressive improvements in global digital datasets and modelling, we should be able to obtain a comprehensive picture of the impacts of human activities and climate warming.

Plisnier P-D, Kayanda R, MacIntyre S, Obiero K, Okello W, Vodacek A, Cocquyt C, Abegaz H, Achieng A, Akonkwa B, Albrecht C, Balagizi C, Barasa J, Abel Bashonga R, Bashonga Bishobibiri A, Bootsma H, Borges AV, Chavula G, Dadi T, De Keyzer ELR, Doran PJ, Gabagambi N, Gatare R, Gemmell A, Getahun A, Haambiya LH, Higgins SN, Hyangya BL, Irvine K, Isumbisho M, Jonasse C, Katongo C, Katsev S, Keyombe J, Kimirei I, Kisekelwa T, Kishe M, Otoung A. Koding S, Kolding J, Kraemer BM, Limbu P, Lomodei E, Mahongo SB, Malala J, Mbabazi S, Masilya PM, McCandless M, Medard M, Migeni Ajode Z, Mrosso HD, Mudakikwa ER, Mulimbwa N'sibula, Mushagalusa Déo, Muvundja FA, Nankabirwa A, Nahimana D, Ngatunga BP, Ngochera M, Nicholson S, Nshombo M, Ntakimazi G, Nyamweya C, Ikwaput Nyeko J, Olago D, Olbamo T, O'Reilly CM, Pasche N, Phiri H, Raasakka N, Salyani A, Sibomana C, Silsbe GM, Smith S, Sterner RW, Thiery W, Tuyisenge J, Van der Knaap M, Van Steenberge M, van Zwieten PAM, Verheyen E, Wakjira M, Walakira J, Ndeo Wembo O, Lawrence T. "Need for harmonized long-term multi-lake monitoring of African Great Lakes.". 2022. AbstractWebsite

To ensure the long-term sustainable use of African Great Lakes (AGL), and to better understand the functioning of these ecosystems, authorities, managers and scientists need regularly collected scientific data and information of key environmental indicators over multi-years to make informed decisions. Monitoring is regularly conducted at some sites across AGL; while at others sites, it is rare or conducted irregularly in response to sporadic funding or short-term projects/studies. Managers and scientists working on the AGL thus often lack critical long-term data to evaluate and gauge ongoing changes. Hence, we propose a multi-lake approach to harmonize data collection modalities for better understanding of regional and global environmental impacts on AGL. Climate variability has had strong impacts on all AGL in the recent past. Although these lakes have specific characteristics, their limnological cycles show many similarities. Because different anthropogenic pressures take place at the different AGL, harmonized multi-lake monitoring will provide comparable data to address the main drivers of concern (climate versus regional anthropogenic impact). To realize harmonized long-term multi-lake monitoring, the approach will need: (1) support of a wide community of researchers and managers; (2) political goodwill towards a common goal for such monitoring; and (3) sufficient capacity (e.g., institutional, financial, human and logistic resources) for its implementation. This paper presents an assessment of the state of monitoring the AGL and possible approaches to realize a long-term, multi-lake harmonized monitoring strategy. Key parameters are proposed. The support of national and regional authorities is necessary as each AGL crosses international boundaries.

Nyakundi JO, Ombui JN, Wanyonyi WC, Mulaa FJ. " Recovery of industrially useful hair and fat from enzymatic unhairing of goatskins during leather processing." Journal of American Leather Chemists Association,. 2022;117(6):241-250.
Wamalwa P, Okoti M MHMKMBB. "Adoption of Improved Biomass Cook Stoves: Case Study of Baringo and West Pokot Counties in Kenya." Journal of Sustainable Bioenergy Systems. 2022;12:21-36.
Abdirahman FA, Wahome RG. "Assessment of the effects of Newcastle disease vaccination on chicken mortality and egg production rates in Machakos town sub-county, Kenya." International Journal of Livestock Production. 2022;12(4):168-175.
Wachira SN, Ndwigah SN, Ongarora DSB, Okaru AO. "Assessment of the Quality of Sodium Hypochlorite and Hydrogen Peroxide product samples in Nairobi County." International Journal of Novel Research and Development. 2022;7(3):503-514.
Moturi CA, Wairimu AG. "Big data adoption in official statistics in Kenya: challenges, opportunities and determinants." Statistical Journal of the IAOS . 2022;38(1):251-262. AbstractWebsite

The data revolution has increased data demands for leveraging on Big Data in the production of statistics. The paper assesses the adoption of Big Data in research institutes in Kenya. Data were collected from 64 data practitioners based in the 24 research institutes that have a mandate to produce and analyse official statistics. The paper establishes the risks and challenges of using Big Data in statistics, identifies the determinants of adoption of Big Data in statistics and validates the relevance of a Technology Adoption Model (TAM) for predicting the adoption. It is the conclusion that there are immense opportunities for Big Data in statistics if the associated risks and challenges are addressed and the identified key determinants prioritized to promote the adoption.

Ngwili N, Thomas L, Githigia S, Muloi D, Marshall K, Wahome R, Roesel K. "Co-infection of pigs with Taenia solium cysticercosis and gastrointestinal parasites in Eastern and Western Uganda." Parasitology research. 2022;121(1):177-189.
Wango GM, Esadia, N. "Dog owners report fewer depression symptoms and a greater sense of social support during the pandemic." The Counsel-ling Magazine. 2022;2(1):48-49.
Wanyama HN, Karega LN, Chimoita EL. "Effect of Use of Tacit Knowledge Transfer Techniques on Organizational Performance of Kenya Agricultural and Livestock Research Organization Researchers." Journal of Agricultural Extension, Economics &Sociology. 2022;0(10)(0(10): 492-502):DOI: 10.9734/AJAEES/2022/v40i1031103.effectof_use_of_tacit_knowledgetransfer_techniques.pdf
Wafula, WM, Wasonga OV, Koech OK, Kibet S. "Factors influencing migration and settlement of pastoralists in Nairobi City, Kenya." Pastoralism: Research, Policy and Practice. 2022;12(2).
Wafula WM, Wasonga OV, Koech OK, Kibet S. "Factors influencing migration and settlement of pastoralists in Nairobi City, Kenya." Pastoralism: Research, Policy and Practice. 2022;12(1):1-14.
MW N, GO O, M M, W S. "Frequency of thyroid dysfunction among rheumatoid arthritis patients at the Kenyatta National Hospital, Nairobi, Kenya." afr j Rheumatal. 2022;10(1):34-44. Abstractfrequency_of_thyroid_dysfunction_among_ra_patients_at_knh.pdf

Background: Rheumatoid Arthritis
(RA) affects 0.5-1% of the adult
population. A higher prevalence of
thyroid dysfunction is observed in
patients with RA compared to the
general population.
Objectives: To establish the
frequency of thyroid dysfunction
among ambulatory RA patients and
to describe the association between
thyroid dysfunction and the patients’
socio-demographic characteristics,
clinical characteristics, level of disease
activity, and their functional status.
Design: This was a cross-sectional
descriptive study.
Methods: Adult patients on follow
up for RA at the outpatient clinic were
sampled. Sociodemographic data was
recorded. The Clinical Disease Activity
Index (CDAI) and Health Assessment
Questionnaire (HAQ) scores were
computed from examination findings
and questionnaires respectively. A
venous blood sample was analyzed for
Thyroid-Stimulating Hormone (TSH),
free triidothyronine (fT3), and free
tetraiodothyronine (fT4). This data
was analyzed to determine frequencies
and associations.
Results: Seventy-six patients were
recruited into the study. Sixty-one
participants were female. The mean
TSH level was 5.8Miu/L. The frequency
of thyroid dysfunction was 47.4%.
Overt hypothyroidism was the most
common form of thyroid dysfunction at
39.5% while 6.6% had Sick Euthyroid.
Majority of the participants, 75%, had
low disease activity, mean CDAI was
11.6. Forty-one (53.9%) participants
had no disability, mean HAQ was
0.5. Correlations between thyroid
dysfunction and advancing age,
duration of disease, level of disease
activity, and functional disability did
not attain statistical significance.
Conclusion: Thyroid dysfunction
is common among patients with RA
with no significant association found
between thyroid dysfunction sociodemographic characteristics, clinical
characteristics, level of disease activity,
and functional status.
Key words: Thyroid dysfunction,
Rheumatoid arthritis, Disease activity,
Functional disability
Rheumatoid Arthritis (RA) is a
symmetric polyarthritis with a variety
of systemic manifestations. In the
general population thyroid dysfunction
affects 1-10% of adults, with variations
in geographical areas, age and sex1
The causes of thyroid dysfunction
include; iodine deficiency, infections
and autoimmune associated thyroid
. Thyroid dysfunction is more
prevalent in patients with autoimmune
diseases such as RA. This is attributed
to overlap of autoimmune conditions
that are initiated by loss of tolerance to
The burden of thyroid dysfunction
among RA patients has been found
to vary between 6-47% in various
studies. The entire spectrum of thyroid
dysfunction has been described,
however, hypothyroidism occurs
more frequently. Patients with thyroid
dysfunction have higher RA disease
activity scores and poorer functional
status measured using the

Wafula KM, Karanja NN, Karuku GN, Esilaba AO. "In-situ Water harvesting technologies and fertilizer rates increase maize and bean yield in the Semi-Arid Katumani, Kenya." Tropical and Subtropical Agroecosystems . 2022;25(3).
Wango GM, Ngerema D, Owang S. "Languishing and Assisting People Get on their Feet." The Counsel-ling Magazine. 2022;2(1):7-9.languishing_and_assisting_people_get_on_their_feet.pdf
Upadhyaya R, Wamalwa H. Learning and capabilities development: Case studies of East African social enterprises.; 2022.
Su R, Wu J, Hu J, Ma L, Ahmed S, Zhang Y, Abdulraheem MI, Birech Z, Li L, Li C, Wei W. "Minimalizing Non-Point Source Pollution Using a Cooperative Ion Selection Electrode System for Estimating Nitrate Nitrogen in Soil." Frontiers in Plant Science. 2022;12:810214.
N ONURAC, J JAMESG, W MUTHUMBIA, W WANG’ONDUV, A SIGANAD. "Performance of African catfish Clarias gariepinus larvae fed on formulated diets containing Spirulina platensis and Eisenia fetida ." East African Journal of Science, Technology and Innovation. 2022;3(2).
Kamuti NM, Mbuthia, P.G., Waruiru, R.M., Githigia SM, Keya EA. "Prevalence, Etiology and Risk Factors Associated with Occurrence of Canine Cutaneous Myiasis in Kitui County, Kenya." Hindawi Journal of Veterinary Medicine International. 2022.
Kamuti NM, Mbuthia PG, Waruiru RM, Githigia SM, Keya EA. "Prevalence, etiology and risk factors associated with occurrence of canine cutaneous myiasis in Kitui County, Kenya." Hindawi Veterinary Medicine International. 2022;Vol. 2022(ID 5699060):9 pages .
Wango GM. "Rejection: What Happens and Why Rejection Hurts so Deeply - and What to do About it." The Counsel-ling Magazine. 2022;2(1):25-30.
Watene G-A, Aboge G, Gitau G, Nthiwa D, Bett B. "Seroprevalence And Risk Factors Of Coxiella Burnetii Infecting Cattle Raised In Pastoral Areas Of Narok, Kenya." Research square. 2022.
Ochieng’ P, Nyandega IA, Wambua B. "Spatial-temporal analysis of historical and projected drought events over Isiolo County. Kenya." Journal of Theor Appl Climatol, Austria, part of Springer Nature . 2022.
Ngwili N, Thomas L, Wahome RG, Githigia S, Johnson N, Roesel K. "Stakeholders' Knowledge, Attitude, and Perceptions on the Control of Taenia solium in Kamuli and Hoima Districts, Uganda." Frontiers in Veterinary Science. 2022:363.
Godman B, Egwuenu A, Wesangula E, Schellack N, Kalungia AC, Tiroyakgosi C, Kgatlwane J. "Tackling antimicrobial resistance across sub-Saharan Africa: current challenges and implications for the future." Expert Opinion on Drug Safety. 2022;21(8):1089-1111.
Githaka NW, Kanduma EG, Wieland B, Darghouth MA, Bishop RP. "Acaricide resistance in livestock ticks infesting cattle in Africa: Current status and potential mitigation strategies." Current Research in Parasitology & Vector-Borne Diseases. 2022:100090. Abstract
Lee AC, Peng B, Du K, Kung H-H, Monserrat B, Cheong S-W, Won CJ, Blumberg G. "Chiral Electronic Excitations in a Quasi-2D Rashba System BiTeI." arXiv preprint arXiv:2202.03569. 2022. Abstract
Lee AC, Peng B, Du K, Kung H-H, Monserrat B, Cheong SW, Won CJ, Blumberg G. "Chiral electronic excitations in the quasi-two-dimensional Rashba system BiTeI." Physical Review B. 2022;105:L161105. Abstract
Zhang Q, Nam J-S, Han J, Datta S, Wei N, Ding E-X, Hussain A, Ahmad S, Skakalova V, Khan AT, others. "Large-Diameter Carbon Nanotube Transparent Conductor Overcoming Performance–Yield Tradeoff." Advanced Functional Materials. 2022;32:2103397. Abstract
Meng T, Shi M, Guo Y, Wang H, Fu N, Liu Z, Huang B, Lei C, Su X, Peng B, others. "Multifunctional Ag-coated CuO microbowl arrays for highly efficient, ultrasensitive, and recyclable surface-enhanced Raman scattering." Sensors and Actuators B: Chemical. 2022;354:131097. Abstract
Su G, Gao A, Peng B, Hu J, Zhang Y, Liu F, Zhang H, Zhan P, Wu W. "Observation of in-plane exciton–polaritons in monolayer WSe2 driven by plasmonic nanofingers." Nanophotonics. 2022. Abstract
Chikwana N, Maina EN, Gavamukulya Y, Bulimo W, Wamunyokoli F. "Antiproliferative Activity, c-Myc and {FGFR}1 Genes Expression Profiles and Safety of Annona muricata Fruit Extract on Rhabdomyosarcoma and {BALB}/c Mice." Journal of Complementary and Alternative Medical Research. 2021:30-46. AbstractWebsite
Rwigi S, Ouma G, Ouma C, Oloo F, Wekesa S, Olang L. "Effects of rainfall variability on water availability in the drylands of Northern Kenya under a changing climate.". In: AGU Fall Meeting Abstracts.; 2021. Abstract

The availability of water in the dryland regions is a function of climatic and land conditions, which determine the amount and distribution of atmospheric water and subsequent partitioning of that water into different hydrological components. Rainfall variability in the drylands affects water, food and livelihood security in the sensitive landscapes. For effective water resource management, it is important to quantify the effect of rainfall variability on the available water resource components to support food security, given that a majority of livelihoods in the drylands are dependent on rainfall. This study assessed rainfall variability and its effects on stream flows in the dryland regions of Turkana County in Northern Kenya. The Coefficient of Variation (CV), Standardised Precipitation Anomaly (SPA) and Mann-Kendal test approaches were used to determine variability and trends of rainfall. The Soil and Water Assessment Tool (SWAT), was employed to simulate hydrological components, including surface runoff, interflow, groundwater flow and the eventual water yield in the streams. The model simulations were driven by the Climate Hazards Group InfraRed Precipitation with Station CHIRPS and the Coordinated Regional Climate Downloading Experiment CORDEX projected rainfalls to establish the current and future water availability respectively. From the results, CV values ranging from 20 to 99% were obtained indicating that the region experiences moderate to high rainfall variability, often resulting in moderate to extreme floods and droughts in the area. The model simulations indicated that the stream-flows are increasing towards the 2020s decade compared to what was flowing in the 1980s decade, as observed between 1981 and 2020 using rainfall. This is probably a result of the increased rainfall observed in this region over the las four decades. Using Representative Concentration Pathways RCP 4.5 and RCP 8.5 projected rainfall scenarios, the model indicated that future stream flows will be higher than present. The findings show that, in the face of climate change scenarios, proper land management is required to promote water and food security in the drylands of sub-Saharan Africa in the future

Nyumba TO, Sang CC, Olago DO, Marchant R, Waruingi L, Githiora Y, Kago F, Mwangi M, Owira G, Barasa R, Omangi S. "Assessing the ecological impacts of transportation infrastructure development: A reconnaissance study of the Standard Gauge Railway in Kenya." PLOS ONE. 2021;16(1):e0246248-. AbstractWebsite

Transportation infrastructure, such as railways, roads and power lines, contribute to national and regional economic, social and cultural growth and integration. Kenya, with support from the Chinese government, is currently constructing a standard gauge railway (SGR) to support the country’s Vision 2030 development agenda. Although the actual land area affected by the SGR covers only a small proportion along the SGR corridor, a significant proportion of the area supports a wide range of ecologically fragile and important ecosystems in the country, with potential wider impacts. This study used a qualitative content analysis approach to gain an understanding and perceptions of stakeholders on the potential ecological impacts of the interactions between the SGR and the traversed ecological systems in Kenya. Three dominant themes emerged: 1) ecosystem degradation; 2) ecosystem fragmentation; and 3) ecosystem destruction. Ecosystem degradation was the most commonly cited impact at while ecosystem destruction was of the least concern and largely restricted to the physical SGR construction whereas the degradation and fragmentation have a much wider footprint. The construction and operation of the SGR degraded, fragmented and destroyed key ecosystems in the country including water towers, protected areas, community conservancies and wildlife dispersal areas. Therefore, we recommend that project proponents develop sustainable and ecologically sensitive measures to mitigate the key ecosystem impacts.

Theunissen F, Cleps I, Goudar S, QURESHI ZAHIDA, Owa OO, Mugerwa K, Piaggio G, Gülmezoglu MA, Nakalembe M, Byamugisha J, Osoti A, Mandeep S, Poriot T, Gwako G, Vernekar S, Widmer M. "Correction to: Cost of hospital care of women with postpartum haemorrhage in India, Kenya, Nigeria and Uganda: a financial case for improved prevention." Reprod Health. 2021;18(1):57.
Theunissen F, Cleps I, Goudar S, QURESHI ZAHIDA, Owa OO, Mugerwa K, Piaggio G, Gülmezoglu MA, Nakalembe M, Byamugisha J, Osoti A, Mandeep S, Poriot T, Gwako G, Vernekar S, Widmer M. "Cost of hospital care of women with postpartum haemorrhage in India, Kenya, Nigeria and Uganda: a financial case for improved prevention." Reprod Health. 2021;18(1):18. Abstract

Access to quality, effective lifesaving uterotonics in low and middle-income countries (LMICs) remains a major barrier to reducing maternal deaths from postpartum haemorrhage (PPH). Our objective was to assess the costs of care for women who receive different preventative uterotonics, and with PPH and no-PPH so that the differences, if significant, can inform better resource allocation for maternal health care.

Gwako GN, Obimbo MM, Gichangi PB, John Kinuthia, James N Kiarie, Gachuno OW, Were F. "Association between obstetric and medical risk factors and stillbirths in a low-income urban setting." Int J Gynaecol Obstet. 2021;154(2):331-336. Abstract

To evaluate the association between obstetric and medical risk factors and stillbirths in a Kenyan set-up.

Yang X, He Z, Zheng Y, Wang N, Mulinge M, Schmit J-C, Steinmetz A, Seguin-Devaux C. "Chemical Constituents of and Their Anti-HIV-1 Activity." Molecules. 2021;26(9). Abstract

Three new (-) and 25 known compounds were isolated from the crude extract of . The chemical structures of new compounds were established by extensive spectroscopic analyses including 1D and 2D NMR and HRESIMS. Cassiabrevone () is the first heterodimer of guibourtinidol and planchol A. Compound was a new chalcane, while was a new naphthalene. Cassiabrevone (), guibourtinidol-(4α→8)-epiafzelechin (), taxifolin (), oleanolic acid (), piceatannol (), and palmitic acid (), exhibited potent anti-HIV-1 activity with IC values of 11.89 µM, 15.39 µM, 49.04 µM, 7.95 µM, 3.58 µM, and 15.97 µM, respectively.

Baguiya A, Bonet M, Cecatti JG, Brizuela V, Curteanu A, Minkauskiene M, Jayaratne K, Ribeiro-do-Valle CC, Budianu M-A, Souza JP, Kouanda S. "Perinatal outcomes among births to women with infection during pregnancy." Arch Dis Child. 2021;106(10):946-953. Abstract

This study is part of the Global Maternal Sepsis Study (GLOSS). It aimed to estimate neonatal near-miss (NNM) and perinatal death frequency and maternal risk factors among births to women with infection during pregnancy in low-income and middle-income countries (LMIC).

Baguiya A, Bonet M, Cecatti JG, Brizuela V, Curteanu A, Minkauskiene M, Jayaratne K, Ribeiro-do-Valle CC, Budianu M-A, Souza JP, Kouanda S. "Perinatal outcomes among births to women with infection during pregnancy." Arch Dis Child. 2021;106(10):946-953. Abstract

This study is part of the Global Maternal Sepsis Study (GLOSS). It aimed to estimate neonatal near-miss (NNM) and perinatal death frequency and maternal risk factors among births to women with infection during pregnancy in low-income and middle-income countries (LMIC).

Brizuela V, Cuesta C, Bartolelli G, Abdosh AA, Abou Malham S, Assarag B, Castro Banegas R, Díaz V, El-Kak F, El Sheikh M, Pérez AM, Souza JP, Bonet M, Abalos E. "Availability of facility resources and services and infection-related maternal outcomes in the WHO Global Maternal Sepsis Study: a cross-sectional study." Lancet Glob Health. 2021;9(9):e1252-e1261. Abstract

Infections are among the leading causes of maternal mortality and morbidity. The Global Maternal Sepsis and Neonatal Initiative, launched in 2016 by WHO and partners, sought to reduce the burden of maternal infections and sepsis and was the basis upon which the Global Maternal Sepsis Study (GLOSS) was implemented in 2017. In this Article, we aimed to describe the availability of facility resources and services and to analyse their association with maternal outcomes.

Oreskovic A, Panpradist N, Marangu D, Ngwane WM, Magcaba ZP, Ngcobo S, Ngcobo Z, Horne DJ, Wilson DPK, Shapiro AE, Drain PK, Lutz BR. "Diagnosing Pulmonary Tuberculosis by Using Sequence-Specific Purification of Urine Cell-Free DNA." J Clin Microbiol. 2021;59(8):e0007421. Abstract

Transrenal urine cell-free DNA (cfDNA) is a promising tuberculosis (TB) biomarker, but is challenging to detect because of the short length (<100 bp) and low concentration of TB-specific fragments. We aimed to improve the diagnostic sensitivity of TB urine cfDNA by increasing recovery of short fragments during sample preparation. We developed a highly sensitive sequence-specific purification method that uses hybridization probes immobilized on magnetic beads to capture short TB cfDNA (50 bp) with 91.8% average efficiency. Combined with short-target PCR, the assay limit of detection was ≤5 copies of cfDNA in 10 ml urine. In a clinical cohort study in South Africa, our urine cfDNA assay had 83.7% sensitivity (95% CI: 71.0 to 91.5%) and 100% specificity (95% CI: 86.2 to 100%) for diagnosis of active pulmonary TB when using sputum Xpert MTB/RIF as the reference standard. The detected cfDNA concentration was 0.14 to 2,804 copies/ml (median 14.6 copies/ml) and was inversely correlated with CD4 count and days to culture positivity. Sensitivity was nonsignificantly higher in HIV-positive (88.2%) compared to HIV-negative patients (73.3%), and was not dependent on CD4 count. Sensitivity remained high in sputum smear-negative (76.0%) and urine lipoarabinomannan (LAM)-negative (76.5%) patients. With improved sample preparation, urine cfDNA is a viable biomarker for TB diagnosis. Our assay has the highest reported accuracy of any TB urine cfDNA test to date and has the potential to enable rapid non-sputum-based TB diagnosis across key underserved patient populations.

Mitchell EJ, Pallotti P, Qureshi ZP, Daniels JP, Oliver M, Were F, Osoti A, Gwako G, Kimani V, Opira J, Ojha S. "Parents, healthcare professionals and other stakeholders' experiences of caring for babies born too soon in a low-resource setting: a qualitative study of essential newborn care for preterm infants in Kenya." BMJ Open. 2021;11(6):e043802. Abstract

Prematurity is the leading cause of global neonatal and infant mortality. Many babies could survive by the provision of essential newborn care. This qualitative study was conducted in order to understand, from a family and professional perspective, the barriers and facilitators to essential newborn care. The study will inform the development of an early warning score for preterm and low birthweight infants in low and middle income countries (LMICs).

Gwako GN, Were F, Obimbo MM, John Kinuthia, James N Kiarie, Gachuno OW, Gichangi PB. "Association between utilization and quality of antenatal care with stillbirths in four tertiary hospitals in a low-income urban setting." Acta Obstet Gynecol Scand. 2021;100(4):676-683. Abstract

About 2.6 million stillbirths per year occur globally with 98% occurring in low- and middle-income countries including Kenya, where an estimated 35 000 stillbirths occur annually. Most studies have focused on the direct causes of stillbirth. The aim of this study was to determine the association between antenatal care utilization and quality with stillbirth in a Kenyan set up. This information is key when planning strategies to reduce the stillbirth burden.

Burton MJ, Ramke J, Marques AP, Bourne RRA, Congdon N, Jones I, Ah Tong BAM, Arunga S, Bachani D, Bascaran C, Bastawrous A, Blanchet K, Braithwaite T, Buchan JC, Cairns J, Cama A, Chagunda M, Chuluunkhuu C, Cooper A, Crofts-Lawrence J, Dean WH, Denniston AK, Ehrlich JR, Emerson PM, Evans JR, Frick KD, Friedman DS, Furtado JM, Gichangi MM, Gichuhi S, Gilbert SS, Gurung R, Habtamu E, Holland P, Jonas JB, Keane PA, Keay L, Khanna RC, Khaw PT, Kuper H, Kyari F, Lansingh VC, Mactaggart I, Mafwiri MM, Mathenge W, McCormick I, Morjaria P, Mowatt L, Muirhead D, Murthy GVS, Mwangi N, Patel DB, Peto T, Qureshi BM, Salomão SR, Sarah V, Shilio BR, Solomon AW, Swenor BK, Taylor HR, Wang N, Webson A, West SK, Wong TY, Wormald R, Yasmin S, Yusufu M, Silva JC, Resnikoff S, Ravilla T, Gilbert CE, Foster A, Faal HB. "The Lancet Global Health Commission on Global Eye Health: vision beyond 2020." Lancet Glob Health. 2021;9(4):e489-e551.Website
MM B, M B, J F, EA L, A A, K A, GA B, WD B, E B, C C, H D, P D'A, L DC, N F, A M. "Diagnostic performance of a colorimetric RT -LAMP for the identification of SARS-CoV-2: A multicenter prospective clinical evaluation in sub-Saharan Africa." EClinicalMedicine. 2021. Abstract
Wangusi BMUYUKANI, Kanja LW, Ole-Mapenay IM, Onyancha JM. "Acute Toxicity, Phytochemical Screening, Analgesic, and Anti-Inflammatory Activities of Aqueous and Methanol Root Extracts of Maerua triphylla A. Rich. (Capparaceae)." Evidence-Based Complementary and Alternative Medicine. 2021;Volume 2021, Article ID 3121785, :9 pages.
Wangusi BMUYUKANI, Kanja LW, Ole-Mapenay IM, Onyancha JM. "Acute Toxicity, Phytochemical Screening, Analgesic, and Anti-Inflammatory Activities of Aqueous and Methanol Root Extracts of Maerua triphylla A. Rich. (Capparaceae)." Evidence-Based Complementary and Alternative Medicin. 2021;2021:11.
Gichure M, Onono J, Wahome R, Gathura P. "Analysis of the benefits and production challenges of working donkeys in smallholder farming systems in Kenya." Veterinary World. 2021;13(11):2346.
Armah FA, Henneh IT, Amponsah IK, Biney RP, F M, J A, W A, Ahmed MA, Adokoh CK, Adukpo G, O AD, Gathumbi PK. "Antidepressant and Anxiolytic Effects and Subchronic Toxicity of the Aerial Parts of Psychotria ankasensis J.B.Hall (Rubiaceae) in Murine Models." Hindawi Veterinary Medicine International. 2021;Volume 2021, Article ID 5543320, 18 pages.armah_et_al_2021.pdf
Andima M, Ndakala A, Derese S, Biswajyoti S, Hussain A, Yang LJ, Akoth OE, Coghi P, Pal C, Heydenreich M, Wong VK-W, Yenesew A. "Antileishmanial and cytotoxic activity of secondary metabolites from Taberneamontana ventricosa and two aloe species." Natural Product Research. 2021:1-5. AbstractNatural Product Research

In this study, the antileishmanial and cytotoxic activities of secondary metabolites isolated from Tabernaemontana ventricosa Hochst. ex A. DC., Aloe tororoana Reynolds, and Aloe schweinfurthii var. labworana Reynolds were investigated. Overall, nineteen known compounds were isolated from the three plant species. The compounds were characterized based on their spectroscopic data. Voacristine and aloenin were the most active compounds against promastigotes of antimony-sensitive Leishmania donovani (IC50 11 ± 5.2 μM and 26 ± 6.5 µM, respectively) with low toxicity against RAW264.7, murine monocyte/macrophage-like cells. The in silico docking evaluation and in vitro NO generation assay also substantially support the antileishmanial effects of these compounds. In a cytotoxicity assay against cancer and normal cell lines, ursolic acid highly inhibited proliferation of lung cancer cells, A549 …

Andima M, Ndakala A, Derese S, Biswajyoti S, Hussain A, Yang LJ, Akoth E, Coghi P, Pal C, Heydenreich M, Wong VK-W, Yenesew A. "Antileishmanial and Cytotoxic Activity of Secondary Metabolites from Taberneamontana ventricosa and Two Aloe Species." Natural Product Research. 2021.
Chepkirui C, Ochieng PJ, Sarkar B, Hussain A, Pal C, Yang LJ, Coghi P, Akala HM, Derese S, Ndakala A, Heydenreich M, Wong VKW, Erdélyi Máté, Yenesew A. "Antiplasmodial and antileishmanial flavonoids from Mundulea sericea." Fitoterapia. 2021;149:104796. AbstractView Website

Five known compounds (1–5) were isolated from the extract of Mundulea sericea leaves. Similar investigation of the roots of this plant afforded an additional three known compounds (6–8). The structures were elucidated using NMR spectroscopic and mass spectrometric analyses. The absolute configuration of 1 was established using ECD spectroscopy. In an antiplasmodial activity assay, compound 1 showed good activity with an IC50 of 2.0 μM against chloroquine-resistant W2, and 6.6 μM against the chloroquine-sensitive 3D7 strains of Plasmodium falciparum. Some of the compounds were also tested for antileishmanial activity. Dehydrolupinifolinol (2) and sericetin (5) were active against drug-sensitive Leishmania donovani (MHOM/IN/83/AG83) with IC50 values of 9.0 and 5.0 μM, respectively. In a cytotoxicity assay, lupinifolin (3) showed significant activity on BEAS-2B (IC50 4.9 μM) and HePG2 (IC50 10.8 μM …

Chikwana N, Maina EN, Gavamukulya Y, Bulimo W, Wamunyokoli F. "Antiproliferative Activity, c-Myc and FGFR1 Genes Expression Profiles and Safety of Annona muricata Fruit Extract on Rhabdomyosarcoma and BALB/c Mice." Journal of Complementary and Alternative Medical Research. 2021;14(4):30-46.
Mamadou Alieu Jallow, Weke Patrick, Lukman Abiodun Nafiu, Ogutu C. "Application of a Discrete time Semi–Markov Model to the Stochastic Forecasting of Capital Assets as Stock." Far East Journal of Theoretical Statistics, . 2021;63(1):1-18.
Williams F, Constantine KL, Ali AA, Karanja TW, Kibet S. "An assessment of the capacity and responsiveness of a national system to address the threat of invasive species: a systems approach." CABI Agriculture and Bioscience. 2021;2(42):1-17.
Gitau AK, Oyieke FA, W.R. Mukabana. "Assessment of the role played by domestic animals in jigger infection in Kandara sub-county, Kenya (case control study)." The Pan African Medical Journal. 2021;39:231.
Gitau AK2021, Oyieke FA, Wolfgang Richard Mukabana. "Assessment of the role played by domestic animals in jigger infection in Kandara sub-county, Kenya (case control study)." Pan African Medical Journal. 2021;39:231.2021-1.pdf
Gitau 2. AK, Oyieke FA, Wolfgang Richard Mukabana. "Assessment of tungiasis management knowledge in Kandara sub county Mukabana, ." Journal of Entomology and Zoology studies. 2021;9(4):127-136.2021-2.pdf
Were SA, Narla R, Mutitu EW, Muthomi JW, Munyua LM, Roobroeck D, Vanlauwe B, E J. "Biochar and vermicompost soil amendments reduce root rot disease of common bean (Phaseolous Vulgaris L.)." African Journal of Biological sciences. 2021;3(1):176-196.
Wangila AJ, Gachuiri CK, Muthomi JW, Ojiem JO. "Biomass yield and quality of fodder from selected varieties of lablab (lablab purpureus l) in Nandi South sub-county of Kenya." Online journal of Animal and Feed Research. 2021;11(1):28-35.
Grossheim L, Ruff P, Ngoma T, Vanderpuye V, Wango GM, Ochieng P, Palmer D, Kouya F, Lasebikan N, Ntekim A, Ngoma M, Bih N, Malloum A, Elzawawy A, Kerr D, Ngwa W. "Cancer and Covid-19 Experiences at African Cancer Centers: The Silver Lining." JCO Global Oncology. 2021;7:410-415.
Ngugi CN, Wachira PM, Mbaka JN, Okoth S, Haukeland S, Thuranira EG. "Characterization and Pathogenicity Test of Entomopathogenic Nematode Steinernema Species-Kalro ." Journal of Agricultural Science. 2021;13(3):93-101.
Ngwili N, Lian T, Githigia S, Muloi D, Marshal K, Wahome R, Roesel K. "co-infection of pigs with Taenia solium cysticercosis and gastrointestinal parasites in Eastern and Western Uganda." Parasitology Research. 2021;2021(
Harmsen H, Mbau JS, Muthama NJ, Wang’ondu VW. "Comparing law enforcement monitoring data and research data suggests an underestimation of bushmeat poaching through snaring in a Kenyan World Heritage Site." African journal of ecology. 2021;(
Wamuyu H, Odote C, Anyango S. "Compensating Toxic Torts in Kenya: Overcoming the Causation Dilemma." The Journal of Sustainable Development, Law and Policy. 2021;12(2):258-281.
Ikua MD, Wambua BN, Omoke KJ. "Constraints and Opportunities for Greenhouse Farming Technology as an Adaptation Strategy to Climate Variability by Smallholder Farmers of Nyandarua County of Kenya." East Africa Journal of Science,Technology & Innovation. 2021;2(Special ). Abstract

Nyandarua County of Kenya has been for a long time, manifested itself as one of the major food baskets in the country. This is because of its high and sustainable output in crop farming i.e., maize, Irish potatoes, wheat, and other horticultural crops like vegetables and fruits. However, this scenario has recently changed because the usual high crop output has not been forthcoming due to recent changes in climatic patterns where rainfall has become very unreliable and temperatures very extreme. In an attempt to adapt to this climate variability and its associated negative impacts on crop farming, smallholder farmers have tried to apply the greenhouse farming technology for them to be able to maintain and or improve the various crop output amid the climatic changes. The study aims to examine and assess the socio-economic determinants and constraints associated with this attempt of adaptation strategy. Using the primary data of 300 respondents (Smallholder farmers) in the County, the study adopted a logistic regression analysis model to associate the demographic, socio-economic, and constraints encountered by the smallholder farmers with the adoption of the greenhouse farming technology. The study results indicate that this adaptation strategy was reported by 25 out the 300 smallholder farmers (5.83%). The study results further suggest that financial constraints (27%) and lack of information (22.3%) are the major constraints preventing smallholder farmers from effectively adopting this adaptation strategy. However, the probability results of logistic regression analysis (68%) indicate that if properly adopted, the method can provide a solution to the currently reduced food shortages and increase food security among the smallholder farmers of Nyandarua County of Kenya.

Simon N. Mbugua, Njenga LW, ROA, Wandiga SO, Onani MO. "COVID-19 and Cancer Therapy: Interrelationships and Management of Cancer Cases in the Era of COVID-19 “.A Review." . Journal of Chemistry. 2021;2021:1-10. Abstract

The COVID-19 global epidemic poses this generation’s biggest worldwide public health challenge probably since the 1918 influenza epidemic. Recent reports on two new variants have triggered a dramatic upsurge in research to understand the pandemic, primarily focussing on the virology, triggers, clinical characteristics, and diagnostic tests including the prevention and management of the novel coronavirus. Whilst such studies are important in managing the present medical emergency, there is a need for further work to include interdependencies between the epidemic and other illnesses. 'is will help in developing effective approaches to treat and manage associated diseases in both the short and the long term. In this regard, people living with cancer are a subgroup that is highly vulnerable to respiratory infections and acute pneumonitis similar to the one caused by the COVID19 virus. 'is is because the state of their immunity is compromised due to malignancy and the adverse effects of anticancer treatments. With annual cancer projections rising globally and an estimated 70 percent of all cancer-related deaths occurring in low- and middle-income countries, the patient population with impaired immune systems that could be adversely impacted by COVID-19 is only anticipated to rise. In this review, we delve into the challenges and health risks facing cancer patients and cancer treatment in the COVID-19 context, with suggestions into viable measures which can be taken to minimize exposure to the risk of contracting COVID-19 for this vulnerable subgroup. New mutations and the prospects offered by vaccines development and how they relate to this class of patients are also discussed

Obiero LM, Abong' GO, W OM, OMAYIO DUKEG, G OE, Villacampa M. "Current practices concerning the environmental management systems among horticultural processing MSMES in Kenya." East African Journal of Science, Technology and Innovation,. 2021;2(special Issue):1-16.current_practices_of_msmes.pdf
Buyinza D, Yang LJ, Derese S, Ndakala A, Coghi P, Heydenreich M, Wong VKW, Möller HM, Yenesew A. "Cytotoxicity of isoflavones from Millettia dura." Natural Product Research. 2021;35(16):2744-2747. AbstractNatural Product Research

The first phytochemical investigation of the flowers of Millettia dura resulted in the isolation of seven isoflavones, a flavonol and a chalcone. Eleven isoflavones and a flavonol isolated from various plant parts from this plant were tested for cytotoxicity against a panel of cell lines, and six of these showed good activity with IC50 values of 6-14 μM. Durmillone was the most active with IC50 values of 6.6 μM against A549 adenocarcinomic human alveolar basal epithelial cancer cell line with low cytotoxicity against the non-cancerous cell lines BEAS-2B (IC50 = 58.4 μM), LO2 hepatocytes (IC50 78.7 μM) and CCD19Lu fibroblasts (IC50 >100 μM).

Lutta, A. I., Wasonga OV, Robinson LW, Nyangito MM, Sircely J. "Determinants of livestock market participation among pastoral communities of Tana River County, Kenya." Environment, Development and Sustainability, . 2021;23(5):7393-7411.
Wang’ombe DN, Mose BR, Maranga SM, MBUYA TM. "Effects of friction stir welding on microstructure and mechanical properties of extruded secondary aluminum 6061 alloy." Materialwissenschaft und Werkstofftechnik. 2021;52(3):270-278 . Abstract

Experiments were carried out to determine the effects of friction stir welding on microstructure and properties of recycled Aluminum 6061 alloy, whose alloy content varied from that of primary alloy. The alloy was processed at tool speed and feed ranges of 530 rev/min–1320 rev/min and 40 mm/min–100 mm/min respectively. Microstructure examination; tensile test and Vickers microhardness evaluation were carried out. Microstructure of the alloy was in four zones including: base metal, heat affected zone, thermo-mechanically affected zone and stirred zone. Average grain size of unprocessed material was 93 μm. Processing the alloy at 530 rev/min and 100 mm/min resulted in grains of average size 93 μm, 183 μm and 7 μm; in base metal, heat affected zone and stirred zone respectively. Tensile failure occurred in heat affected zone; that was exposed to high heat. The alloy hardness decreased to a minimum in heat affected zone, followed by a brief rise in thermo-mechanically affected zone, to another maximum in stirred zone. Processed zone hardness was inversely proportional to tool speed and directly proportional to feed rate. Increase in the speed and decrease in feed, increased heat which deteriorated the properties.

Dabasso BH, Wasonga OV, Irungu P, Kaufmann B. "Emerging pastoralist practices for fulfilling market requirements under stratified cattle production systems in Kenya's drylands." Animal Production Science. Accepted 23 February 2021. 2021.
Murunga J, Muriithi MK, Wawire NW. "Estimating the size of the informal sector in Kenya, Cogent Economics & Finance." Cogent Economics & Finance. 2021;9(1):1-15.
Mushori J, Charles Mallans Rambo, Wafula CM, Matu J. "Evaluating Contractors’ Safety Record and Its Influence on Performance of Road Infrastructural Projects." World Journal of Engineering and Technology. 2021;2021(9):203-228 .
Wanjira J, Ndiwa TC, Gichuki N, Wykstra M. "Evaluating the efficacy of flashing lights in deterring livestock attacks by predators: a case study of Meibae Community Conservancy, Northern Kenya." East African Journal of Science, Technology and Innovation. 2021;2(3).
Namungu L, Mburu C, Were FH. "Evaluation of Occupational Lead Exposure in Informal Work Environment in Kenya." Chemical Science International Journal, . 2021;30(11):45-54.
A A Fabuyide, Cornish LA, Apata AO, Rading GO, Muobeni TN, Witcomb MJ, Jain PK, Borode JO. "Experimental Liquidus Surface Projection and Isothermal Section at 1000C of the V-Ni-C System, J of Phase Equilibria and Diffusion.". 2021.
Maina, wanjiku. "From Vernacular to Modern: Transitioning East African Traditional House Design to Contemporary." Africa Habitat Review. 2021;14(3):2081-2093.
Walter Onchere, Weke P, Ottieno J, Ogutu: C. "Graduation of Term Assurance Data using Frailty Approach." Afrika Statistika. 2021;16(3):2805-2817.
Mgalula ME, Wasonga OV, Hülsebusch C, and Hensel URO. "Greenhouse gas emissions and carbon sink potential in Eastern Africa rangeland ecosystems: A review." Pastoralism: Research, Policy and Practice . 2021;11(19).
Ncebere JM, Mbuthia PG, Waruiru RM, Gathumbi PK. "Gross and Histopathology of Goats Feeding on Opuntia stricta in Laikipia County, Kenya." Hindawi Veterinary Medicine International. 2021;Volume 2021(Article ID 8831996, 12 pages).
Ncebere JM, Mbuthia PG, Waruiru RM, Gathumbi PK. "Gross and histopathology of goats feeding on Opuntia stricta in Laikipia County, Kenya." Hindawi Veterinary Medicine International. 2021;2021(Article ID 8831996).
Wanja ND, Agnèse J-F, Ford AGP, Day JJ, Ndiwa TC, Turner GF, Getahun A. Identifying and conserving Tilapiine cichlid species in the twenty-first century. Springer; 2021.
Makinya KJ, Wagacha JM, Odhiambo JA, Likhayo P, Edoh-Ognakossan K, Tefera T, Abass A, Mutungi C. "The importance of store hygiene for reducing post-harvest losses in smallholder farmers’ stores: Evidence from a maize-based farming system in Kenya." Journal of Stored Products Research. 2021;90(DOI:10.1016/j.jspr.2020.101757):101757.
Wangai M M, Inyega JO, M M, JM. K. "Influence of ISO 9001 standards on quality of academic programmes in universities in Kenya: a case of bachelor of education programme of the University of Nairobi." Journal of Pedagogy, Andragogy and Heutagogy in Academic Practice. 2(2):34-48.. 2021;2(2):34-48.
Wangai MM, Inyega JO, Mugambi MM, Kalai JM. "Influence of ISO 9001 standards on quality of academic programmes in universities in Kenya: a case of university of Nairobi." Journal of Pedagogy, Andragogy and Heutagogy in Academic Practice(ISSN: 2708-261X),. 2021;2(2):34-48.
T H, W KI, G. MR. "The Influence of Parental Incomes on Internal Efficiency of Public Primary Schools in Western Province-Rwanda." Journal of Humanities And Social Science (IOSR-JHSS) . 2021;26(6):06-16.
Wangai MM, Inyega J, Mugambi M, Kalai J. "Influence of Total Quality Management and Knowledge Management on Quality of University Academic Programmes: A Literature Review." Journal of Pedagogy, Andragogy and Heutagogy in Academic Practice. 2021;2(1):1-14.
Wangai M M, Inyega J, M M, J. K. "Influence of Total Quality Management and Knowledge Management on Quality of University Academic Programmes: A Literature Review." Journal of Pedagogy, Andragogy and Heutagogy in Academic Practice. . 2021;2(1):1-14.
Wangai, M.M., Inyega, H. N., Mugambi MM, Kalai JM. "Influence of Total Quality Management and Knowledge Management on Quality of University Academic Programmes: A Literature Review." Journal of Pedagogy, Andragogy and Heutagogy in Academic Practice (JPAHAP). 2021;2(1):1-14.
Wangai MM, Inyega JO, Mugambi MM, Kalai JM. "Influence of total quality management and knowledge management on quality of university academic programmes: a literature review." Journal of Pedagogy, Andragogy and Heutagogy in Academic Practice(ISSN: 2708-261X),. 2021;2(1):1-14.
Karamshetty V, DeVries H, Wassenhove LVN, Dewilde S, Minnaard W, Ongarora D, Abuga K, Yadav P. "Inventory Management Practices in Private Healthcare Facilities in Nairobi County." Prod. Oper. Manag.. 2021;31(2):828-846. Abstract

Universal health coverage (UHC) is an integral part of the United Nations sustainable development goals. The private sector plays a prominent role in achieving UHC, being the primary source of essential medicines for many people. However, many private healthcare facilities in low‐ and middle‐income countries (LMICs) have insu_cient stocks of essential medicines. At the same time, these same facilities carry excessive quantities of certain drugs, leading to obsolescence. This suggests poor inventory control. To propose potential remedies it is vital to fully understand the underlying causes. In semi‐structured interviews with managers of private healthcare facilities in Nairobi, we asked them about their 1) inventory control systems, 2) inventory control skills, 3) time/human resource constraints, 4) budget constraints, 5) motivations for inventory control, and 6) suppliers. Our results suggest that the problems are driven by resource limitations (budget and time/human resources), managerial issues (relating to skills and systems), and market mechanisms that limit overage and underage costs. Unavailability at the supplier level and motivations for inventory control are relatively minor issues. We posit that the key causes are interlinked and stem from wider issues in the market and regulatory environment. Our results challenge prevalent beliefs about medicine supply chains in LMICs and lead to alternative hypotheses. Testing these hypotheses could improve our understanding of inventory management in private healthcare facilities and aid progress in achieving UHC.

Mavuti SK, Mbaria JM, Maina JG, Mbuthia PG, Waruiru RM. "Levels of lead, mercury and cadmium in farmed Oriochromis niloticus and Clarias gariepinus in Nyeri County, Kenya." International Journal of Fisheries and Aquatic Studies. 2021;9(4):230-233.
Japheth NR, Rukwaro PR, Wachira-Towey IN. "Management of Steel Reinforcement Works Procedures Impact on the Health of Workers in Building Construction Sites Case study of Nairobi County, Kenya." Journal of Entrepreneurship & Project management. 2021;Volume 5(1).
Mulei IR, Mbuthia PG, Waruiru RM, Nyaga PN, Mutoloki S, Evensen Ø&. "Management practices, farmers’ knowledge of diseased fish and their occurrence in fish farms in Nyeri County, Kenya ." Hindawi Veterinary Medicine International. 2021;2021(Article ID 8896604).
Mulei, I., Mbuthia, P.G., Waruiru, R.M., Nyaga, P. N., Mutoloki, Evensen. "Management practices, farmers’ knowledge of diseased fish and their occurrence in fish farms in Nyeri County, Kenya." Hindawi Veterinary Medicine International. 2021.
Weboko FI, Nyongesa BS, Makhanu MN, Luna KDG, Dey GES, Viloria IL. "A Minimally Invasive Treatment Option For Restoring Esthetics." Journal of the Kenya Dental Association. 2021;12(2):952-957.
Irene Wakio Mwakesi, Wahome RG, Ichang’i DW. "Mining Impacts on Society: A Case Study of Taita Taveta County, Kenya." Journal of Environmental Protection. 2021;11(11):986-997.
Wakhungu CN, Okoth S, Wachira P, N.A O. "Mycotoxins contaminating herbs and spices in Africa: A review." African Journal of Biological Sciences. 2021;3(3):10-28.
Ochora DO, Kakudidi E, Namukobe J, Heydenreich M, Coghi P, Yang LJ, Mwakio EW, Andagalu B, Roth A, Akala HM, Wong VKW, Yenesew A. "A new benzophenone, and the antiplasmodial activities of the constituents of Securidaca longipedunculata fresen (Polygalaceae)." Natural Product Research. 2021:1-9. AbstractView Website

Extracts from Securidaca longipedunculata showed antiplasmodial activities against reference clones and clinical isolates using SYBR Green I method. A new benzophenone, 2,3,4,5-tetramethoxybenzophenone (1) was isolated and characterized along with seven known compounds: 4-hydroxy-2,3-dimethoxybenzophenone (2); 3-hydroxy-5-methoxybiphenyl (3), methyl-2-hydroxy-6-methoxybenzoate (4), benzyl-2-hydroxy-6-methoxybenzoate (5), 2-hydroxy-6-methoxybenzoic acid (6), 2,4,5-trimethoxybenzophenone (7) and 2-methoxy-3,4-methylenedioxybenzophenone (8). Compounds 1 and 2 showed ex vivo antiplasmodial activities (IC50 28.8 μM and 18.6 μM, respectively); while 5 and 8 showed in vivo activities (IC50 19.7 μM and 14.5 μM, respectively) against D6 strain. In a cytotoxicity assay, all the extracts (with an exception of the MeOH extract of the leaves) and pure compounds were not toxic to the …

Dufitumukiza, A., Wanjala, G., Khatete I. "Nine year basic education policy interventions and students’ enrolments rates at lower secondary level: A lesson from Rwanda." Journal of Higher Education Policy and Leadership Studies, . 2021;2(1):94-112.
Walter Onchere, Weke P, Ottieno J, Ogutu: C. "Non Central Gamma Frailty with Application to Life Term Assurance Data." Advances and Applications in Statistics. 2021;67( 2):237-253.
AM K, Waudo J, Were G. "Nutrition status of adolescents in Kenya.". In: Nutrition status of adolescents in Kenya. Nairobi: Williams Publishers ltd; 2021.
Osoro EM, Wandiga SO, Madadi VO, Abong’o DA. "Occurrence and Distribution of Polybrominated Diphenyl Ethers in Sediments from Nairobi River Basin, Kenya, East Africa." International Journal of Scientific Research in Science, Engineering and Technology. 2021;8(1):274-286. Print ISSN: 2395-1990 | Online ISSN : 2394-4099. doi :
Osoro EM, Wandiga S, Madadi V, Abongo D. "Occurrence and Distribution of Polybrominated Diphenyl Ethers in Water from Nairobi River Basin, Kenya, East Africa." Africa Journal of Physical Sciences ISSN: 2313-3317. 2021;6. AbstractAfrica Journal of Physical Sciences

Polybrominated diphenyl ethers are linked to adverse health effects that includethyroid hormone disruption, neuro-developmental deficit, abnormal pregnancy, and potential carcinogens. This study was aimed at assessing the concentrationsof selected Polybrominated diphenyl ether compounds in water of Nairobi River. Water samples were collected by grab method from nine sites along the river andanalysed for brominated diphenyl ethers using gas chromatography coupled withmass spectrometer. The mean concentration of polybrominated diphenyl ethersresidue in water ranged from< 0.0009 to 72.89±6.15 ng/L. The dominantcongeners were 2, 2′, 4, 4′-tetra-bromodiphenyl ether, 2, 2′, 4, 4′, 5, 5′-hexabromodiphenylether, 2, 2′, 4, 4′, 6-penta-bromodiphenyl ether, 2, 2′, 4, 4′, 5, 5′-hexabromodiphenylether and 2, 2′, 4, 4′, 5, 6′-hexa-bromodiphenyl. The highest meanconcentration of 2, 2′, 4, 4′-tetra-bromodiphenyl ether was 72.89±6.15 ng/L, 2, 2′, 3, 4, 4′-penta-bromodiphenyl ether was 14.08±0.68 ng/L, 2, 2′, 4, 4′, 6-pentabromodiphenylether was 43.67±1.47 ng/L, 2, 2′, 4, 4′, 5, 5′-hexa-bromodiphenylether was 24.78±2.49 ng/L, and 2, 2′, 3, 4, 4′, 5′, 6-hepta-bromodiphenyl ether was11. 75±0.97 ng/L. Consequently, as these compounds are known to bioaccumulatein fatty tissues, continued use of the river water poses a health risk toanimals and humans due to contamination across the food chain.

Osoro EM, Wandiga S, Madadi V, Abongo D. "Polybrominated Diphenyl Ethers Pollution in Urban and Rural Settings’ Ambient Air in Kenya: An Insight into Concentration Levels, Compositional Profile and Seasonal Variation." Africa Journal of Physical Sciences ISSN: 2313-3317. 2021;6. AbstractAfrica Journal of Physical Sciences

Air samples were collected from three urban and one rural sites in Kenya with the aim of establishing pollution levels of Polybrominated Diphenyl Ethers. Forty-eight air Samples were collected by passive air sampling, Soxhlet extracted and analysed for brominated diphenyl ethers using gas chromatography coupled with mass spectrometer. The mean concentration of polybrominated diphenyl ethers residue in air ranged from≤ 0.9 to 152.72±3.19 pgm− 3. The predominant congener was 2, 2′, 4, 4′-tetra-bromodiphenyl ether with mean concentration range of 1.94±0.03 to 152.72±3.19 pgm− 3 followed by 2, 2′, 4, 4′, 5-penta-bromodiphenyl ether with mean concentration range of 1.32±0.06 to 66.83±1.19 pgm− 3. Seasonal variations of the pollutants showed a high level of Polybrominated Diphenyl Ethers in hot dry season in range of 1.94±0.03 to 152.72±3.19 pgm− 3. Air samples from Dandora and Industrial area both from urban location recorded high concentrations of the analysed polybrominated diphenyl ethers compared with the air samples from the rural location.

Walter Onchere, Weke P, Ottieno J, Ogutu C. "Positive Stable Frailty Approach in the Construction of Dependence Life–Tables." s,Open Journal of Statistics. 2021;11( 1):506-523,.
Kosgei PK, Bebora LC, Waiboci LW, Waringa N, Kiambi SG, Kitala PN. "Prevalence and factors associated with brucellosis in livestock in Baringo County, Kenya." Journal of Veterinary Medicine and Animal Health. 2021.abstract3.pdf
and Wilson K Kimani, J Nguhiu-Mwangi JMSMDW. Prevalence of Urinary Tract Conditions and Factors Associated with Urolithiasis in Domestic Cats in Nairobi, Kenya. Nairobi: University of Nairobi; 2021.
Wabwoba, C.N, Mugambi M, Okoth UA. "Promoting acquisition of English Language Among Pupils through the Lens of Active learning." Journal of Pedagogy, Andragogy and Heutagogy in Academic Practice. 2021;2(2):18-33.
Ngwili N, Johnson N, Wahome R, Githigia S, Roesel K, Thomas L. "A qualitative Assessment of the Context and Enabling Environment for the Control of Taenia solium Infections in Endemic Settings." PLOS Negl Trop Diseases. 2021;15(6.
Abuga KO, Kigera ST, Wanyama M, Nandama WM, Kibwage IO. "Quality Control Results of Pharmaceuticals Analyzed in the Mission for Essential Drugs and Supplies (MEDS) Laboratory During the Period 2013-2017." East Cent. Afr. J. Pharm. Sci.. 2021;24(2):57-66. Abstract

During the 2013-2017 period, the MEDS laboratory received and processed 6853 samples. Samples were sourced from Kenya and other sub-Saharan Africa countries. The samples submitted comprised Kenyan manufactured (31.9%) and internationally manufactured products (67.9%) while nine samples were of unknown origin. Analysis was carried out according to compendial and/or in-house specifications. The non-compliance rate was 5.1% consisting of 1.2 % local and 3.8% imports. The top ten drug classes with high failure rates were antimyasthenics (50.0%), antiseptics/disinfectants (24.7%), anthelminthics (22.0%), thyroid/antithyroid drugs (20.0%), nutrient mixtures (18.5%), uricosurics (12.5%), waters (11.6%), mixed anti-infectives (11.1%), hemostatics (10.0%) and nootropics (10.0%). Full compliance was however, recorded with laxatives, antidiarrheals, antihemorrhoidals, prokinetics, antithrombotics, antithrombocytopenia agents, vasopressors, anti-arrhythmic drugs, anti-anginal drugs, disease modifying antirheumatic drugs, antimigraine drugs, vertigolytics, muscle relaxants, bisphosphonates, joint lubricants, hormones, anticholinergics, osmotic diuretics, hypophosphatemics, lubricants, minerals, amino acids/peptides, immunomodulatory agents, choleretics, antidotes, lozenges, ear drops, proteins/glycoproteins, herbal products, X-ray contrast media, vaccines, environmental monitoring, medical devices/equipment and cleaning validation swabs. A total of 23 substandard and falsified medicines devoid of active ingredients were encountered over the five-year period. The results obtained demonstrate the need to strengthen regulatory stringency in order to curb incidences of substandard and falsified medicines.

Vanleeuwen J, Muraya J, Gitau GK, Makau DN, Crane BM, McKenna SLB, Wichtel JJ. "Randomised controlled trial on estrus and conception impacts of reproductive and nutrition interventions on Kenyan smallholder dairy farms." East African Journal of Science, Technology and Innovation. 2021;2(4).
Harmsen H, Wang’ondu VW, Mbau JS, Muthama NJ. "Randomized hotspot strategy is effective in countering bushmeat poaching by snaring." Biological Conservation. 2021;253.
Harmsen H, Wangondu V, Mbau JS, J M, J M. "Randomized hotspot strategy is effective in countering bushmeat poaching by snaring." Biological conservation. 2021;253(108909).
Vanleeuwen J, Muraya J, Gitau G, Makau D, Crane B, McKenna S, Wichtel J. "Seroprevalence and risk factors of Neospora caninum and Bovine Viral Diarrhoea Virus in smallholder dairy cattle in Kenya." East African Journal of Science, Technology and Innovation. 2021;3(1).
Walter Onchere, Weke P, Ottieno J, Ogutu C. "Shared Frailty Model with Application in Joint–Life Annuity Assurance." Advances and Applications in Statistics. 2021;68( 1):23-42.
Murunga J, Muriithi MK, Wawire NW. "Size of the Informal Sector and Tax Revenue in Kenya. Journal of Economics and Public Finance." Journal of Economics and Public Finance. 2021;7(5).
Wairire G, Okemwa P, Akinyi M. "Society and Successful Transition: Female Genital Mutilation." The Counsel-ling Magazine. 2021;1(1):19-24.
Bota D, Bunyasi A, Amayo A, Wachira JW, Okello JO. "Strengthening Medical Laboratory Systems in Kenya: An Innovative Biosafety Training Model." Applied Biosafety. 2021;00(00):1-11.
Murunga J, Wawire NW, Muriithi MK. "Tax Revenue Productivity of Tax Reforms in Kenya. International Journal of Economics and Finance." Canadian Center of Science and Education. 2021;13(12).
W G, M O, GO O. "Treatment Approaches for Multiple Myeloma: A Review." Journal of Kenya Association of Physicians. 2021;3(1):29-34. Abstract

Background: Multiple Myeloma (MM) is a
haematological cancer characterized by complications
of end-organ damage and subsequently high mortality.
Previously, there were few therapies available with
minimal survival benefit for most patients. Survival
was less than a year in many countries. The survival of
MM patients can range from 6 months to over 10 years,
with a median of 6 years, depending on stage of the
disease at diagnosis and prognostic factors. However,
with the advent of newer immune modulating agents
and novel therapies, there exists an opportunity to
improve the management of MM.
Objective: The purpose of this review is to discuss
the current chemotherapy and novel agents available
for treatment of Multiple Myeloma and highlight
emerging therapies in treatment of Multiple Myeloma,
some of which are now locally available in Kenya.
Data Sources: International Guidelines on Treatment
of Multiple Myeloma; Published articles from peerreviewed
journals; ESMO, NCCN guidelines on
Multiple Myeloma
Conclusion: New MM therapies have been shown to
improve progression-free survival and overall survival
of to upto 82% at four years. Some of these therapies
are now accessible locally through government
funding. In combination with a wholesome approach
which includes appropriate supportive care, there
exists an opportunity to improve the quality and
standard of care of MM patients in Kenya to replicate
the success of that in developed countries.
Key words: Multiple myeloma, Cancer

Makhanu MN, Alsadig MAM, Nyongesa BS, Weboko FI, Alcorta PP. "Unsuccessful Closed Surgical Exposure of an Impacted Maxillary Canine Managed by Open Surgical Exposure." Journal of the Kenya Dental Association. 2021;12(2):946-953.2021_kda_journal_volume_12_no_2.pdf

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