Prevalence of Cytotoxin-associated gene A (CagA) positive Helicopter pylori strains in asymptomatic H. pylori-infected children attending Kenyatta National Hospital, Nairobi and correlation with risk factors associated with infection acquisition

Citation:
S S, C S-K, er CS G, W W. "Prevalence of Cytotoxin-associated gene A (CagA) positive Helicopter pylori strains in asymptomatic H. pylori-infected children attending Kenyatta National Hospital, Nairobi and correlation with risk factors associated with infection acquisition." East African Journal of Pathology. 2015;2(1):2-7.

Abstract:

Background: Helicobacter pylori bacteria colonize the gastric mucosa of 20-80% of humans worldwide. Approximately 60-70% of H. pylori strains possess the Cytotoxinassociated gene A (CagA gene) and express the CagA protein, an oncoprotein and a highly immunogenic virulence factor that has been linked to gastric disease.
Objective: To determine the prevalence ofCagA positive H.pylori among asymptomatic children attending Kenyatta National Hospital (KNH), Nairobi.
Design: Cross-sectional descriptive study at KNH paediatric outpatient clinic and paediatric wards and at the immunology laboratory, University of Nairobi.
Subjects: Children aged 2-13 years attending KNH, presenting with non-gastrointestinal tract conditions.
Methods: Socio-demographic information was collected by direct interview of the participants' parents/guardians (respondents) and entered into a study questionnaire. Serum samples from the subjects were tested by ELISA for the anti-H. pylori IgG antibody. Those that tested positive were tested for anti-CagA IgG antibody.
Results: A total of 175 children with a mean age of 7.5 years were enrolled, 57.3 % being males. The overall prevalence of H. pylori was 50.3%. CagA positive H. pylori prevalence among those who tested positive for H. pylori was 64.8%. There was significant positive correlation of H. pylori seropositivity with age (p

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