Toll-like receptor expression and responsiveness are increased in viraemic HIV-1 infection

Citation:
Lester RT, Yao X-D, Ball BT, McKinnon LR, Kaul R, Wachihi C, Jaoko W, Plummer FA, Rosenthal KL. "Toll-like receptor expression and responsiveness are increased in viraemic HIV-1 infection.". 2008.

Abstract:

Toll-like receptors (TLR) are important in pathogen recognition and may play a role in HIV disease. We evaluated the effect of chronic untreated and treated HIV-1 infection on systemic TLR expression and TLR signalling.Together, these data indicate that chronic viraemic HIV-1 is associated with increased TLR expression and responsiveness, which may perpetuate innate immune dysfunction and activation that underlies HIV pathogenesis, and thus reveal potential new targets for therapy.

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