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2020
James. N. Mugo, Nancy N. Karanja, Gachene CS, Klaus Dittert, Nyawade SO, Schulte-Geldermann E. "Assessment of soil fertility and potato crop nutrient status in Central and Eastern Highlands of Kenya." Nature research. 2020.
S.Senda T, Lance W. Robinson, K.K.Gachene C, Kironchi G, Doyo J. "An assessment of the implications of alternative scales of communal land tenure formalization in pastoral systems." Land use Policy. 2020;94.
Folayan MO, Tantawi ME, Schroth R, Kemoli AM, Gaffar B, Amalia R, Feldens CA. "Association between environmental health, ecosystem vitality and early childhood caries." Front Pediatr. 2020;2020; 8:196.(2020; 8:196.):2020; 8:196.
Folayan M, Tantawi ME, Schroth RJ, Vukovic A. "Associations between early childhood caries and malnutrition and anaemia: a global perspective." BMC Nutrition J. 2020;2020:=;6:16.(2020:=;6:16.):2020:=;6:16.
GO O, EK G, S N. "Audit on the management of early rheumatoid arthritis in Nairobi." Afr J Rheumatol. 2020;8(1):22-25. Abstractaudit_on_the_management_of_early_rheumatoid_arthitis_in_nairobi.pdf

Background
: Clinical audit for rheumatoid arthritis on patients over
the age of 18 years in Nairobi, Kenya within the first three months of referral to a specialist. Objective: The audit gives detailed
information on the following; access to care, quality of treatment and
care received by patients from their rheumatology team in these first 3 months and the early impact of arthritis on the patient’s life.
Design: This was a cross-sectional
survey. Results
: The audit included 100 patients referred to the Nairobi Arthritis
Clinic between January and April 2018. A majority (54%) had symptoms for
more than 6 months before being referred to a rheumatologist. Most of
the patients (83%) were seen within 3 weeks of referral. Disease Modifiying
Antirheumatic Drugs (DMARDs) were commenced in 90% within 6 weeks of
being seen at the clinic. Treatment to target was done in 98% of the patients
with a further 60% able to access the clinic within a day of flare of symptoms. Conclusion: The audit revealed the
need to improve on referral time to the rheumatologist. It was encouraging
to note that once they saw the rheumatologists the patients were
commenced on the proper treatment with the treat to target strategy. An area
that needs improvement is the time to access the rheumatologist in case of
side effect from the treatment or flare of the disease

N A, NM A, MO F, Y K, JI V, OB A-B, SZ M, S A, H H, S B, DA M, A R, I K, M M, M R, V P, S C, Y C, E J, JL C, K N, A S, G G, A P, P P, D M, J K, MM A, A A, MA D, M N, I H, MM A, AP V, A I, AM K, ME T. "Behavior change due to COVID-19 among dental academics - The theory of planned behavior: stresses, worries, training, and pandemic severity." PLoS ONE. 2020;15(9): e0239961(15(9): e0239961):15(9): e0239961.
AN S, A K, Benki-Nugent S, Chebet D GL, Wamalwa D, Farquhar C, G J-S, Slyker JA, John-Stewart GC. "Caregivers’ report of HIV-associated oral manifestations among HIV-unexposed, exposed, and infected Kenyan children." Int J Paediatr Dent. 2020;2021;00:1-8.(2021;00:1-8.):2021;00:1-8.
Shem Otoi Sam, Manene MM, Isaac C Kipchirchir, Pokhariyal GP. "Cointegration analysis of youth unemployment in Kenya." International Journal of Statistics and Applied Mathematics. 2020;5(3):129-133. AbstractWebsite

In this paper analysis of contribution of macroeconomic variables gross domestic product (GDP), external debt (ED), foreign direct investment (FDI), private investment (PI), youth population (POP), and youth literacy rate (LR) to youth unemployment(YUN) in Kenya over time is done. The analysis is done under framework of cointegration of time series data. First, logarithmic transformation of the series is carried out followed by stationarity test to determine the order of stationarity. The Philip-Ouliaris cointegration test is carried out to determine whether the series are individually cointegrated in a pair-wise manner. Then the Johansen cointegration test is conducted to determine the rank of cointegration. The paper does not proceed to identify cointegration relations as that is superfluous as far as estimation of linear cointegration model is concerned. Finally the linear cointegration equation of the macroeconomic variables is estimated and interpreted. Philip-Ouliaris test reveals that six pairs are I(0) while 15 pairs are I(1). The Augmented Dickey-Fuller test finds that GDP, FDI, and ED are stationary at level, i.e. without differencing whereas PI, LR, YUN, and POP are stationary of first difference. According to Johansen cointegration test, the rank of cointegration is 3, revealing three cointegration relations among the variables used. The results indicate that 1% increase in GDP, ED, FDI, and LR increases YUN by 0.356204%, 0.269%, 0.002441%, and 0.154216 respectively. Contrarily, 1% increasein population reduces youth unemployment by 0.350833%.The model is subjected to F-test and p-value test and found to be statistically significant

Shem Otoi Sam, Manene MM, Isaac C Kipchirchir, Pokhariyal GP. "Cointegration analysis of youth unemployment in Kenya." International Journal of Statistics and Applied Mathematics. 2020;5(3): 129-133. AbstractWebsite

In this paper analysis of contribution of macroeconomic variables gross domestic product
(GDP), external debt (ED), foreign direct investment (FDI), private investment (PI), youth
population (POP), and youth literacy rate (LR) to youth unemployment (YUN) in Kenya over
time is done. The analysis is done under framework of cointegration of time series data. First,
logarithmic transformation of the series is carried out followed by stationarity test to determine
the order of stationarity. The Philip-Ouliaris cointegration test is carried out to determine
whether the series are individually cointegrated in a pair-wise manner. Then the Johansen
cointegration test is conducted to determine the rank of cointegration. The paper does not
proceed to identify cointegration relations as that is superfluous as far as estimation of linear
cointegration model is concerned. Finally the linear cointegration equation of the
macroeconomic variables is estimated and interpreted. Philip-Ouliaris test reveals that six pairs
are I(0) while 15 pairs are I(1). The Augmented Dickey-Fuller test finds that GDP, FDI, and
ED are stationary at level, i.e. without differencing whereas PI, LR, YUN, and POP are
stationary of first difference. According to Johansen cointegration test, the rank of
cointegration is 3, revealing three cointegration relations among the variables used. The results
indicate that 1% increase in GDP, ED, FDI, and LR increases YUN by 0.356204%, 0.269%,
0.002441%, and 0.154216 respectively. Contrarily, 1% increase in population reduces youth
unemployment by 0.350833%.The model is subjected to F-test and p-value test and found to
be statistically significant.

Gawriluk TR, Simkin J, Hacker CK, Kimani JM, Kiama SG, Ezenwa VO, Seifert AW. "Complex Tissue Regeneration in Mammals Is Associated With Reduced Inflammatory Cytokines and an Influx of T Cells." Front. Immunol.. 2020;11(1695):1-19.
Akinyemi R, Sarfo F, Abd-Allah F, Ogun Y, Ogeng'o J. "Conceptual framework for establishing the African Stroke Organization .". 2020. AbstractWebsite

Abstract

Africa is the world's most genetically diverse, second largest, and second most populous continent, with over one billion people distributed across 54 countries. With a 23% lifetime risk of stroke, Africa has some of the highest rates of stroke worldwide and many occur in the prime of life with huge economic losses and grave implications for the individual, family, and the society in terms of mental capital, productivity, and socioeconomic progress. Tackling the escalating burden of stroke in Africa requires prioritized, multipronged, and inter-sectoral strategies tailored to the unique African epidemiological, cultural, socioeconomic, and lifestyle landscape. The African Stroke Organization (ASO) is a new pan-African coalition that brings together stroke researchers, clinicians, and other health-care professionals with participation of national and regional stroke societies and stroke support organizations. With a vision to reduce the rapidly increasing burden of stroke in Africa, the ASO has a four-pronged focus on (1) research, (2) capacity building, (3) development of stroke services, and (4) collaboration with all stakeholders. This will be delivered through advocacy, awareness, and empowerment initiatives to bring about people-focused changes in policy, clinical practice, and public education. In the spirit of the African philosophy of Ubuntu "I am because we are," the ASO will harness the power of diversity, inclusiveness, togetherness, and team work to build a strong, enduring, and impactful platform for tackling stroke in Africa.

Mundo L, Porro LD, Granai M, Siciliano MC, Mancini V, Santi R, Marcar L, Vrzalikova K, Vergoni F, Stefano GD, Schivoni G, Segreto G, Noel Onyango, Nyagol JA, Amato T, Bellan C, Anagnostopoulos I, Falini B, Leoncini L, Lazzi S. "Correction: Frequent traces of EBV infection in Hodgkin and non-Hodgkin lymphomas classified as EBV-negative by routine methods: expanding the landscape of EBV-related lymphomas." Modern Pathology. 2020:10.1038/s41379-020-0608-y.
M G, L M, AU A, MC S, H R, V M, N O, J N, OA A, I M, S M, W W, M B, PP P, L Q-M, F F, S L, Leoncini L, T M. "Correction: Immune landscape in Burkitt lymphoma reveals M2-macrophage polarization and correlation between PD-L1 expression and non-canonical EBV latency program. ." Infect Agent & Cancer . 2020;15(39):doi:10.1186/s13027-020-00304-9.
A K, Folayan MO, Sabbah W, El Tantawi M, Ramos-Gomez F. "Country Profile of the Epidemiology and Clinical Management of Early Childhood Caries.". In: Country Profile of the Epidemiology and Clinical Management of Early Childhood Caries. Lausanne: Frontiers Media SA.; 2020.
Shagwira H, Mwema FM, MBUYA TO, Adediran A. "Dataset on impact strength, flammability test and water absorption test for innovative polymer-quarry dust composite." Data in Brief. 2020;29( April):105384. Abstracthttps://doi.org/10.1016/j.dib.2020.105384

In this article data on impact strength, flammability and water absorption tests for innovative plastic-quarry dust composite is presented. The composites were prepared through moulding with virgin HDPE and PP plastics and quarry dust. The quarry dust was used at 0%, 5%, 20%, 40%, 60% and 80% weight percentages. The prepared samples were characterised for strength, fire resistance and hydrophobic properties using Charpy impact, flammability and water absorption tests respectively. For impact strength test was conducted according to ISO 179–1:2010 (E). The flammability test was conducted according to ASTMD 2863 while the water absorption test was carried out in accordance to ASTM D 570–98. These data illustrate the potential of the plastic quarry dust composite application in construction industry and model for regeneration of waste plastics for green building technologies.

S D, GO O, V O-H. "Depression and its association with disease activity and quality of life in patients with rheumatoid arthritis at the Kenyatta National Ho." Afr J Rheumatol. 2020;8(1):15-21. Abstractdepression_and_its_association_with_disease_activity.pdf

Background: Rheumatoid arthritis
is a systemic inflammatory disease that affects the synovial membrane,
resulting in the structural damage of cartilage, bone and ligaments. The
course of RA differs between patients, and its severity can range from selflimiting
disease to severe destruction and systemic complications. RA affects
patients physically, psychologically and socially. Patients experience pain,
joint swelling, stiffness, functional limitations and fatigue and overall poor
quality of life. In addition, they report anxiety and depressive symptoms
and concerns about increased physical limitations. Experiencing
psychological distress may inflate the subjective severity of patient-reported
symptoms such as pain and tenderness. Furthermore, patients experience a
loss of independence and restrictions in participation, i.e. a decrease in
socializing which may in turn propagate symptoms of depression. An accurate
description of the relationship between depression, disease severity and quality
of life is necessary for our setting. If an interaction exists, then there is a
group of vulnerable patients who could benefit from earlier identification
of depression and the impact their disease has on HRQoL and appropriate
management provided. Objective: To determine the prevalence
of depression and the relationship between depression, disease activity
and quality of life in ambulatory patients with rheumatoid arthritis at
the Kenyatta National Hospital.Design: A descriptive-cross sectional

Sala, M.S., Otieno JD, Nzuma, M.J., Mureithi, S.M. "Determinants of Pastoralists’ Participation in Commercial Fodder Markets for Livelihood Resilience in Drylands of Northern Kenya: Case of Isiolo." Pastoralism: Research, Policy and Practice . 2020;10(1):DOI: 10.1186/s13570-020-00166-1.
Chirwa TF, Zingoni ZM, Munyewende P, Manda SO, Mwambi H, Kandala N-B, Kinyanjui S, Young T, Musenge E, Simbeye J, Musonda P, Mahande MJ, Weke P, Onyango NO, Kazembe L. "Developing excellence in biostatistics leadership, training and science in Africa: How the Sub-Saharan Africa Consortium for Advanced Biostatistics (SSACAB) training unites …." AAS Open Research. 2020;3(51). AbstractWebsite

The increase in health research in sub-Saharan Africa (SSA) has led to a high demand for biostatisticians to develop study designs, contribute and apply statistical methods in data analyses. Initiatives exist to address the dearth in statistical capacity and lack of local biostatisticians in SSA health projects. The Sub-Saharan African Consortium for Advanced Biostatistics (SSACAB) led by African institutions was initiated to improve biostatistical capacity according to the needs identified by African institutions, through collaborative masters and doctoral training in biostatistics. SACCAB has created a critical mass of biostatisticians and a network of institutions over the last five years and has strengthened biostatistics resources and capacity for health research studies in SSA. SSACAB comprises 11 universities and four research institutions which are supported by four European universities. In 2015, only four universities …

Murage JK, Amugune BK, Njogu PM, S.N.Ndwigah. "Development and application of aspectrophotometric method in qualityevaluation of benzimidazole anthelminthicsin Nairobi city county." Future Journal of Pharmaceutical Sciences . 2020;6:74.
Sola L, Levin NW, Johnson DW, Pecoits-Filho R, Aljubori HM, Chen Y, Claus S, Collins A, Cullis B, Feehally J, Harden PN, Hassan MH, Ibhais F, Kalantar-Zadeh K, Levin A, Saleh A, Schneditz D, Tchokhonelidze I, Kazancioglu RT, Twahir A, Walker R, Were AJO, Yu X, Finkelstein FO. "Development of a framework for minimum and optimal safety and quality standards for hemodialysis and peritoneal dialysis." Kidney International Supplements. 2020.
U B, M M, J M, Mwang’ombe, S G. "Disease surveillance and farmers’ knowledge of Brachiaria (Syn. Urochloa) grass diseases in Rwanda." African Journal of Range & Forage Science. 2020;. https://doi.org/10.2989/10220119.2020.1810774.
Langat MK, Ndunda B, Salter C, Odusina BO, Isyaka SM, Mas-Claret E, Onocha PA, Midiwo JO, Nuzillard J-M, Mulholland DA. "Diterpenoids from the stem bark of Croton megalocarpoides Friis & M. G. Gilbert." Phytochemistry Letters. 2020;39:1-7.
Langat MK, Ndunda BM, Salter C, Odusina BO, Isyaka SM, Mas-Claret E, Onocha PA, Midiwo JO, Nuzillard J-M, Mulholland DA. "Diterpenoids from the stem bark of Croton megalocarpoides Friis & MG Gilbert." Phytochemistry Letters. 2020;39:1-7. AbstractPhytochemistry Letters

Description
Five previously undescribed compounds, megalocarpoidolide I (1), megalocarpoidolide J (3), 12-epi-crotonzambefuran A (4), megalocarpoidolide K (5), 1-trans-p-hydroxycoumaroyl–geranylgerani-1-ol (6) were isolated from the stem bark of Croton megalocarpoides Friis & M. G. Gilbert. The known ent-trachyloban-18-ol, megalocarpoidolide B, megalocarpoidolide C (2), megalocarpoidolide H, crotocorylifuran, 7,8-dehydrocrotocorylifuran, 1,2-dehydrocrotocorylifuran-2-one, acetyl aleuritolic acid, lupeol, N-trans-p-coumaroyl-3′,4′-dihydroxyphenylethylamine, dodecyl trans-ferulate and lignoceryl trans-ferulate were also isolated. The structures of the compounds were determined using NMR, IR spectroscopy and HRMS. The structure of compound 1 was determined using Logic for Structural Determination (LSD). Compounds 1, 2 and 3 that were selected for screening based on their ability to add diversity to the …

Shah P. "Domestication of the Ramsar Convention in Kenya." Towards realizing of Vision 2030: Kenya Policy Briefs. Office of the DVC Research, Innovation and Extension. University of Nairobi. . 2020;1(1):13-14.
Brizuela V, Bonet M, Romero CLT, Abalos E, Baguiya A, Fawole B, Knight M, Lumbiganon P, Minkauskienė M, Nabhan A, Osman NB, Qureshi ZP, Souza JP. "Early evaluation of the ‘STOP SEPSIS!’ WHO Global Maternal Sepsis Awareness Campaign implemented for healthcare providers in 46 low, middle and high-income countries." British Medical Journal . 2020;10(5). AbstractWebsite

Objective To evaluate changes in awareness of maternal sepsis among healthcare providers resulting from the WHO Global Maternal Sepsis Study (GLOSS) awareness campaign.

Design Independent sample precampaign/postcampaign through online and paper-based surveys available for over 30 days before campaign roll-out (pre) and after study data collection (post). Descriptive statistics were used for campaign recognition and exposure, and odds ratio (OR) and percentage change were calculated for differences in awareness, adjusting for confounders using multivariate logistic regression.

Setting and participants Healthcare providers from 398 participating facilities in 46 low, middle and high-income countries.

Intervention An awareness campaign to accompany GLOSS launched 3 weeks prior to data collection and lasting the entire study period (28 November 2017 to 15 January 2018) and beyond.

Main outcome measures Campaign recognition and exposure, and changes in awareness.

Results A total of 2188 surveys were analysed: 1155 at baseline and 1033 at postcampaign. Most survey respondents found the campaign materials helpful (94%), that they helped increase awareness (90%) and that they helped motivate to act differently (88%). There were significant changes with regard to: not having heard of maternal sepsis (−63.4% change, pre-OR/post-OR 0.35, 95% CI 0.18 to 0.68) and perception of confidence in making the right decisions with regard to maternal sepsis identification and management (7.3% change, pre-OR/post-OR 1.44, 95% CI 1.01 to 2.06).

Conclusions Awareness raising campaigns can contribute to an increase in having heard of maternal sepsis and an increase in provider perception of confidence in making correct decisions. Offering the information to make accurate and timely decisions while promoting environments that enable self-confidence and support could improve maternal sepsis identification and management.

S W, A K, S K, I M. "Effect of Combining Clinical Teaching Tools on Clinical Judgment Skills of Undergraduate Nursing Students in Kenya." South Asian Research Journal of Nursing and Healthcare . 2020;2(1):117-123.
Li D, Zhang Y, Guo Q, Sun X, Zhang H, Wang S, Birech Z, Hu J. "An efficient LSPR method to quantitatively detect dimethoate: Development, characterization and evaluation. ." Plos one. 2020;15(9):e0239632.
Nyawade S, Gitari HI, Karanja NN, Gachene CKK, Schulte-Geldermann E, Sharma K, Parker ML. "Enhancing Climate Resilience of Rain-Fed Potato Through Legume Intercropping and Silicon Application.". 2020.
Obiero DK, Ombui JN, Onyuka AS, Sasia AA. "Evaluation of the physical properties of leathers tanned with plectranthus barbatus Andrewa extract.." African Journal of Biotechnology. 2020;19(3):137-143.
Ndegwa R, Simiyu J, E Ayieta, Odero N. "A Fast and Accurate Analytical Method for Parameter Determination of a Photovoltaic System Based on Manufacturer’s Data." Journal of Renewable Energy. 2020;(2020):1-18.
Bohlin-Nizzetto P, Melymuk L, B.White K, Kalina J, Madadi VO, SamAdu-Kumi, Prokeš R, Přibylová P, Klánová J. "Field- and model-based calibration of polyurethane foam passive air samplers in different climate regions highlights differences in sampler uptake performance." Atmospheric Environment. 2020;238(117742).
Mundo L, Porro LD, Granai M, Siciliano MC, Mancini V, Santi R, Marcar L, Vrzalikova K, Vergoni F, Stefano GD, Schivoni G, Segreto G, Noel Onyango, Nyagol JA, Amato T, Bellan C, Anagnostopoulos I, Falini B, Leoncini L, Lazzi S. "Frequent traces of EBV infection in Hodgkin and non-Hodgkin lymphomas classified as EBV-negative by routine methods: expanding the landscape of EBV-related lymphomas." Modern Pathology . 2020.
Elusah J, Bulimo WD, Opanda SM, Symekher SL, Wamunyokoli F. "Genetic diversity and evolutionary analysis of human respirovirus type 3 strains isolated in Kenya using complete hemagglutinin-neuraminidase (HN) gene." PLOS ONE. 2020;15(3):e0229355. Abstractelusa_et_al_2020.pdfWebsite

Human respirovirus type 3 (HRV3) is a leading etiology of lower respiratory tract infections in young children and ranks only second to the human respiratory syncytial virus (HRSV). Despite the public health importance of HRV3, there is limited information about the genetic characteristics and diversity of these viruses in Kenya. To begin to address this gap, we analyzed 35 complete hemagglutinin-neuraminidase (HN) sequences of HRV3 strains isolated in Kenya between 2010 and 2013. Viral RNA was extracted from the isolates, and the entire HN gene amplified by RT-PCR followed by nucleotide sequencing. Phylogenetic analyses of the sequences revealed that all the Kenyan isolates grouped into genetic Cluster C; sub-clusters C1a, C2, and C3a. The majority (54%) of isolates belonged to sub-cluster C3a, followed by C2 (43%) and C1a (2.9%). Sequence analysis revealed high identities between the Kenyan isolates and the HRV3 prototype strain both at the amino acid (96.5–97.9%) and nucleotide (94.3–95.6%) levels. No amino acid variations affecting the catalytic/active sites of the HN glycoprotein were observed among the Kenyan isolates. Selection pressure analyses showed that the HN glycoprotein was evolving under positive selection. Evolutionary analyses revealed that the mean TMRCA for the HN sequence dataset was 1942 (95% HPD: 1928–1957), while the mean evolutionary rate was 4.65x10-4 nucleotide substitutions/site/year (95% HPD: 2.99x10-4 to 6.35x10-4). Overall, our results demonstrate the co-circulation of strains of cluster C HRV3 variants in Kenya during the study period. This is the first study to describe the genetic and molecular evolutionary aspects of HRV3 in Kenya using the complete HN gene.

SM Mwendwa, Mbuvi JP, Kironchi G, Gachene CKK. "A geopedological approach to soil classification to characterize soils of Upper Kabete Campus Field, University of Nairobi, Kenya ." Tropical and Subtropical Agroecosystems. 2020.
SM Mwendwa, Mbuvi JP, Kironchi G, Gachene CKK. "A geopedological approach to soil classification to characterize soils of Upper Kabete Campus Field, University of Nairobi, Kenya ." Tropical and Subtropical Agroecosystems. 2020.
Folayan MO, Tantawi ME, Vukovic A, Schroth R, Alade M, Mehebbi S, Al-Batayneh OB, Arheiam A, Amalia R, Gaffar B, Onyejaka NK, Daryanavard H, Kemoli A, Diaz ACM, grewal N. "Governance, maternal well-being and early childhood caries in 3-5 year olds." BMC Oral Health. 2020;2020; 20:166(2020; 20:166):2020; 20:166.
Elsayed HM, Wadee S, Zaki MS, Were AJO, Ashuntantang GE, Bamgboye EL, Davids MR, Hafez MH, Mahamat M, Naicker S, Niang A, Seck SM, Swanepoel CR, Tannor EK, Twahir A, Yao HK. "Guidelines for the prevention, detection and management of the renal complications of COVID-19 in Africa." African Journal of Nephrology. 2020;98(5):S117-S134.Website
Susan Gachau, Matteo Quartagno, NJAGI EDMUNDNJERU, Nelson Owuor, English M, Ayieko P. "Handling missing data in modelling quality of clinician-prescribed routine care: sensitivity analysis of departure from missing at random assumption." Statistical methods in medical research. 2020;29(10):3076-3092. AbstractWebsite

Missing information is a major drawback in analyzing data collected in many routine health care settings. Multiple imputation assuming a missing at random mechanism is a popular method to handle missing data. The missing at random assumption cannot be confirmed from the observed data alone, hence the need for sensitivity analysis to assess robustness of inference. However, sensitivity analysis is rarely conducted and reported in practice. We analyzed routine paediatric data collected during a cluster randomized trial conducted in Kenyan hospitals. We imputed missing patient and clinician-level variables assuming the missing at random mechanism. We also imputed missing clinician-level variables assuming a missing not at random mechanism. We incorporated opinions from 15 clinical experts in the form of prior distributions and shift parameters in the delta adjustment method. An interaction between trial intervention arm and follow-up time, hospital, clinician and patient-level factors were included in a proportional odds random-effects analysis model. We performed these analyses using R functions derived from the jomo package. Parameter estimates from multiple imputation under the missing at random mechanism were similar to multiple imputation estimates assuming the missing not at random mechanism. Our inferences were insensitive to departures from the missing at random assumption using either the prior distributions or shift parameters sensitivity analysis approach

Ongong’a E, Ongaro J, Silvestrov S. "Hom-Lie Structures on Complex 4-Dimensional Lie Algebras." Dobrev V. (eds) Lie Theory and Its Applications in Physics. Springer Nature. 2020;335:373. Abstract

n/a

M G, L M, AU A, MC S, H R, V M, N O, J N, OA A, I M, S M, W W, M B, PP P, L Q-M, F F, S L, Leoncini L, T M. "Immune landscape in Burkitt lymphoma reveals M2-macrophage polarization and correlation between PD-L1 expression and non-canonical EBV latency program. ." Infectious Agents & Cancer . 2020;15(28).
S. S, Gitau G.K., J. VL, C. M, P. K. "Impact of calf feeding practices on calf growth and health in smallholder dairy farms in Nyeri County, Kenya." East African Journal of Science, Technology, and Innovation. 2020;1(3):2707-0425.
E L, M K, S S, FH R, Kinuthia J, L S, W J, H A, A K, F E, John-Stewart, Fredricks DN, McClelland S. "Impact of preconception vaginal microbiota on women’s risk of spontaneous preterm birth: Protocol for a prospective case-cohort study." BMJ Open J. 2020;2020; 10:e035186(2020; 10:e035186):2020; 10:e035186.
Toroitch W, Migosi J, Sakaja Y. "Influence of Resource Controls on the Performance of Infrastructural Projects in ECDE County Projects in Soy Sub-County." International Journals of Academics & Research. 2020;7(8):38-44.
Mbevi, E., Sakaja, Y., Ochieng O. "Influence of Road Safety Training on Motorcycle Accidents in Kimilili Sub – County, Bungoma County – Kenya." International journals of academics & research - ijarke, . 2020;2(2):9-17.
Mbugua JK, Mbui DN, Mwaniki J, mwaura F, Sheriff S. "Influence of Substrate Proximate Properties on Voltage Production in Microbial Fuel Cells." Journal of Sustainable Bioenergy Systems. 2020;10(02):43. AbstractJournal of Sustainable Bioenergy Systems

Description
In the current study, we investigate the influence of proximate properties of five different fruits on voltage and current generated from a double chamber microbial fuel cell. Fruits comprising of avocado, tomato, banana, watermelon and mango were analyzed for proximate properties using standard methods. Rumen fluid was used as the inoculum in fabricated H-shaped double chamber fuel cells with graphite rods electrodes at room temperature. The voltage and current generated were monitored daily for 30 days using a DT9205A digital multi-meter. The average moisture content for the fruits samples ranged from 82.86% - 95.16% while the crude fat was in the range of 0.12% - 0.33% with avocado having fat levels at 9.03%. Carbohydrates level was the highest in banana at 19.24% and the lowest in tomato waste at 2.93%. Tomato waste produced the highest voltage of 0.702 V on day 20 while lower voltage was noted in watermelon fruit wastes at 0.019 V. The voltage and current increased linearly with time for all the fruit wastes. These results indicate that substrate proximate properties influence the voltage and current generated in microbial fuel cell. In addition, moisture content and carbohydrates level were the major factors that influence microbial fuel cells performance.

S C, Khatete I, G. W. "Influence of Trainees’ Entry Qualification on Skill Development for Kenya’s Realization of Her Development Agenda." International Journal of Research and Innovation in Social Science (IJRISS). 2020;IV(XI).
Nchiozem-Ngnitedem V-A, Omosa LK, Bedane KG, Derese S, Spiteller M. "Inhibition of ProInflammatory Cytokine Release by Flavones and Flavanones from the Leaves of Dracaena steudneri Engl." Planta Medica. 2020:DOI: 10.1055/a-1306-1368.alexe_et_al_2020_planta_medica.pdf
StellaKiambi, Onono JO, Kang’ethe E, Aboge GO, Murungi MK, Muinde P, Akoko J, Momanyi K, Rushton J, Fevre EM, Alarcon P. "Investigation of the governance structure of Nairobi dairy value chain and its influence on food safety." . Preventive Veterinary Medicine. 2020;28(4).
StellaKiambi, Onono JO, Kang’ethe E, O.Aboge G, K.Murungi M, Muinde P, Akoko J, Momanyi K, Rushton J, M.Fèvre E, Alarcon P. "Investigation of the governance structure of the Nairobi dairy value chain and its influence on food safety." Preventive Veterinary Medicine . 2020;179:https://doi.org/10.1016/j.prevetmed.2020.105009.
Owor RO, Derese S, Bedane KG, Zühlke S, Ndakala A, Spiteller M. "Isoflavones from the seedpods of Tephrosia vogelii and pyrazoisopongaflavone with anti-inflammatory effects." Fitoterapia. 2020;146:104695. AbstractFitoterapia

Description
Phytochemical investigation of Tephrosia vogelii seedpods led to the isolation of twelve compounds: vogelisoflavone A (1), vogelisoflavone B (2), isopongaflavone (3), onogenin, luteolin, 4′,7-dihydroxy-3′-methoxyflavanone, trans-p-hydroxycinnamic acid, tephrosin, 2-methoxygliricidol, dehydrorotenone, 6a,12a-dehydro-α-toxicarol and pinoresinol. Compounds 1 and 2 are reported as new natural products. Isopongaflavone (3) was structurally modified using hydrazine to pyrazoisopongaflavone (4). These compounds were characterized based on their NMR and HRESIMS data. Further, four compounds (1–4) were evaluated for their anti-inflammatory effects in lipopolysaccharide (LPS)-stimulated peripheral blood mononuclear cells (PBMCs). Treatment of the LPS-stimulated PBMCs with the compounds at a concentration of 100 μM suppressed the secretion of interleukin IL-1β interferon-gamma (IFN-γ …

Owor RO, Derese S, Bedane KG, Zühlke S, Ndakala A, Spiteller M. "Isoflavones from the seedpods of Tephrosia vogelii and pyrazoisopongaflavone with anti-inflammatory effects." Fitoterapia. 2020;146:104695.
N A, Aly NM, Folayan MO, Mohebbi SZ, P H-H, S B, Y K, DA M, A R, I K, M M, AA S, OB A-B, M R, V P, S C, G G, A P, D M, A A, MA D, M N, P P, J K, Y C, JL C, E J, MM A, MM A, I H, AP V, A I, AM K, ME T. "Knowledge of Dental Academics About the COVID-19 Pandemic: A Multi-Country – Online Survey." BMC Medical Education. 2020;2020; 20:399.(2020; 20:399.):2020; 20:399.
Jennings Mayo-Wilson L, M M, Yi G, Mak’anyengo, MO, Davoust M, ML M, Stefan Baral, Fred M. Ssewamala, Glass NE. "Lessons learned from using respondent driven sampling (RDS) to assess sexual risk behaviors among Kenyan young adults living in urban slum settlements: A process evaluation." PLoS ONE . 2020;15(4).
"Kibet S, S C, Shackleton R, Schaffner U. "Managing native ‘bush encroachment’ in East African rangelands.". In: Restoring African Drylands. Wageningen: Tropenbos International, Wageningen, the Netherlands; 2020.
Otieno SP, S. W. Masks. (Mrs) ANM, ed. Talent Empire; 2020.
Weboko FI, Nyongesa BS, Makhanu MN, Santos MS, Luna KDG, Dey GES, Viloria IL. "Mineral Trioxide Aggregate Pulpotomy for Apexogenesis of an Immature Permanent Molar. A Case Report." Endodontic Society of the Philippines journal . 2020;32(1):16-21.
Mbugua SN, Sibuyi NRS, Njenga LW, Odhiambo RA, Wandiga SO, Meyer M, Lalancette RA, Onani MO. "New Palladium(II) and Platinum(II) Complexes Based on Pyrrole Schiff Bases: Synthesis, Characterization, X ray Structure, and Anticancer Activity." ACS Omega . 2020;5(25):14942−14954 . AbstractACS OMEGA

New palladium (Pd)II and platinum (Pt)II complexes (C1−C5) from the Schiff base ligands, R-(phenyl)methanamine (L1), R-(pyridin-2-yl)methanamine (L2), and R-(furan2-yl)methanamine (L3) (R-(E)-N-((1H-pyrrol-2-yl) methylene)) are herein reported. The complexes (C1−C5) were characterized by FTIR, 1 H and 13C NMR, UV−vis, and microanalyses. Single-crystal X-ray crystallographic analysis was performed for the two ligands (L1−L2) and a Pt complex. Both L1 and L2 belong to P21/n monoclinic and P-1 triclinic space systems, respectively. The complex C5 belongs to the P21/c monoclinic space group. The investigated molar conductivity of the complexes in DMSO gave the range 4.0−8.8 μS/cm, suggesting neutrality, with log P values ≥ 1.2692 ± 0.004, suggesting lipophilicity. The anticancer activity and mechanism of the complexes were investigated against various human cancerous (Caco-2, HeLa, HepG2, MCF-7, and PC-3) and noncancerous (MCF-12A) cell lines using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and Apopercentage assays, respectively. C5 demonstrated strong DNA-binding affinity for calf thymus DNA (CTDNA) with a binding constant of 8.049 × 104 M−1 . C3 reduced cell viability of all the six cell lines, which included five cancerous cell lines, by more than 80%. The C5 complex also demonstrated remarkably high selectivity with no cytotoxic activity toward the noncancerous breast cell line but reduced the viability of the five cancerous cell lines, which included one breast cancer cell line, by more than 60%. Further studies are required to evaluate the selective toxicity of these two complexes and to fully understand their mechanism of action

Mbugua SN, Sibuyi NRS, Njenga LW, Odhiambo RA, Wandiga SO, Meyer M, Lalancette RA, Onani MO. "New Palladium(II) and Platinum(II) Complexes Based on Pyrrole Schiff Bases: Synthesis, Characterization, X‑ray Structure, and Anticancer Activity." ACS Omega. 2020. Abstractdx.doi.org

New palladium (Pd)II and platinum (Pt)II complexes (C1–C5) from the Schiff base ligands, R-(phenyl)methanamine (L1), R-(pyridin-2-yl)methanamine (L2), and R-(furan-2-yl)methanamine (L3) (R-(E)-N-((1H-pyrrol-2-yl) methylene)) are herein reported. The complexes (C1–C5) were characterized by FTIR, 1H and 13C NMR, UV–vis, and microanalyses. Single-crystal X-ray crystallographic analysis was performed for the two ligands (L1–L2) and a Pt complex. Both L1 and L2 belong to P21/n monoclinic and P-1 triclinic space systems, respectively. The complex C5 belongs to the P21/c monoclinic space group. The investigated molar conductivity of the complexes in DMSO gave the range 4.0–8.8 μS/cm, suggesting neutrality, with log P values ≥ 1.2692 ± 0.004, suggesting lipophilicity. The anticancer activity and mechanism of the complexes were investigated against various human cancerous (Caco-2, HeLa, HepG2 …

Nyawade SO, Karanja NN, Gachene CKK, Gitari HI, Schulte-Geldermann E, Parker M. "Optimizing soil nitrogen balance in a potato cropping system through legume intercropping.". 2020.
Langat SK, Eyase FL, Berry IM, Nyunja A, Bulimo W, Owaka S, Ofula V, Limbaso S, Lutomiah J, Jarman R, Distelhorst J, Sang RC. "Origin and evolution of dengue virus type 2 causing outbreaks in Kenya: Evidence of circulation of two cosmopolitan genotype ." Virus Evol. 2020;6(1):veaa026. Abstractveaa026.pdfWebsite

Dengue fever (DF) is an arboviral disease caused by dengue virus serotypes 1-4 (DENV 1-4). Globally, DF incidence and disease burden have increased in the recent past. Initially implicated in a 1982 outbreak, DENV-2 recently reemerged in Kenya causing outbreaks between 2011 and 2014 and more recently 2017-8. The origin and the evolutionary patterns that may explain the epidemiological expansion and increasing impact of DENV-2 in Kenya remain poorly understood. Using whole-genome sequencing, samples collected during the 2011-4 and 2017-8 dengue outbreaks were analyzed. Additional DENV-2 genomes were downloaded and pooled together with the fourteen genomes generated in this study. Bioinformatic methods were used to analyze phylogenetic relationships and evolutionary patterns of DENV-2 causing outbreaks in Kenya. The findings from this study have shown the first evidence of circulation of two different Cosmopolitan genotype lineages of DENV-2; Cosmopolitan-I (C-I) and Cosmopolitan-II (C-II), in Kenya. Our results put the origin location of C-I lineage in India in 2011, and C-II lineage in Burkina Faso between 1979 and 2013. C-I lineage was the most isolated during recent outbreaks, thus showing the contribution of this newly emerged strain to the increased DENV epidemics in the region. Our findings, backed by evidence of recent local epidemics that have been associated with C-I in Kenya and C-II in Burkina Faso, add to the growing evidence of expanding circulation and the impact of multiple strains of DENV in the region as well as globally. Thus, continued surveillance efforts on DENV activity and its evolutionary trends in the region, would contribute toward effective control and the current vaccine development efforts.

Segera D, Mbuthia M, Nyete A. "Particle Swarm Optimized Hybrid Kernel-Based Multiclass Support Vector Machine for Microarray Cancer Data Analysis.". In: Prime Archives in Medicine. Hyderabad (India): Vide Leaf; 2020.
Buyana K, Lwasa S, Tugume D, Mukwaya P, Walubwa J, Owuor S, Kasaija P, Sseviiri H, Nsangi G, Byarugaba D. "Pathways for resilience to climate change in African cities. Environ. Res. Lett. 15 (2020) 073002.". 2020.2020_environmental_research_letters_journal.pdf
O. A’G, T. M, W. OM, F. N’ang’a, G. O’P, M. MD, D. M, M. A, S G. "Phytochemicals in leaves and roots of selected Kenyan orange fleshed Sweet potato (OFSP) varieties. International Journal of Food Science." International Journal of Food Science . 2020;2020(1-2):1-11.
N A, N A, S M, S A, H H, S B, D M, A R, I K, O A-B, Y K, M R, V P, S C, K N, G G, A P, M F, A S, M M, A AA, D M, P P, J K, Y C, M D, J V, M A, J C, M N, I H, A V, A I, A K, E J, ME T. "Preparedness of dental academic institutions to manage the COVID-19 pandemic: a global survey." Int. J Environ Res Public Health. 2020;2021; 18:1445(2021; 18:1445):2021; 18:1445.
Umuhoza T, Bulimo WD, Oyugi J, Schnabel D, Mancuso JD. "Prevalence and factors influencing the distribution of influenza viruses in Kenya: Seven-year hospital-based surveillance of influenza-like illness (2007-2013)." PLoS One. 2020;15(8):e0237857. Abstractumuhoza_et_al_2020.pdfWebsite

BACKGROUND: Influenza viruses remain a global threat with the potential to trigger outbreaks and pandemics. Globally, seasonal influenza viruses' mortality range from 291 243-645 832 annually, of which 17% occurs in Sub-Saharan Africa. We sought to estimate the overall prevalence of influenza infections in Kenya, identifying factors influencing the distribution of these infections, and describe trends in occurrence from 2007 to 2013. METHODS: Surveillance was conducted at eight district hospital sites countrywide. Participants who met the case definition for influenza-like illness were enrolled in the surveillance program. The nasopharyngeal specimens were collected from all participants. We tested all specimens for influenza viruses with quantitative reverse transcriptase real-time polymerase chain reaction (RT-qPCR) assay. Bivariate and multivariate log-binomial regression was performed with a statistically significant level of p<0.005. An administrative map of Kenya was used to locate the geographical distribution of surveillance sites in counties. We visualized the monthly trend of influenza viruses with a graph and chart using exponential smoothing at a damping factor of 0.5 over the study period (2007-2013). RESULTS: A total of 17446 participants enrolled in the program. The overall prevalence of influenza viruses was 19% (n = 3230), of which 76% (n = 2449) were type A, 21% (n = 669) type B and 3% (n = 112) A/ B coinfection. Of those with type A, 59% (n = 1451) were not subtyped. Seasonal influenza A/H3N2 was found in 48% (n = 475), influenza A/H1N1/pdm 2009 in 43% (n = 434), and seasonal influenza A/ H1N1 in 9% (n = 88) participants. Both genders were represented, whereas a large proportion of participants 55% were

Simon Patrick Baenyi, Junga JO, Christian Keambou Tiambo, Ahadi Bwihangane Birindwa, Katcho Karume, Getinet Mekuriaw Tarekegn, Ochieng JW. "Production Systems, Genetic Diversity and Genes Associated with Prolificacy and Milk Production in Indigenous Goats of Sub-Saharan Africa: A Review." Scientific Research Publishing. 2020;10(4):735-749.
Simon Patrick Baenyi, Junga JO, Christian Keambou Tiambo, Ahadi Bwihangane Birindwa, Katcho Karume, Getinet Mekuriaw Tarekegn, Ochieng JW. "Production Systems, Genetic Diversity and Genes Associated with Prolificacy and Milk Production in Indigenous Goats of Sub-Saharan Africa: A Review." Open Journal of Animal Sciences. 2020;10(4):735-749.
Simon Patrick Baenyi, Junga JO, Christian Keambou Tiambo, Ahadi Bwihangane Birindwa, Katcho Karume, Getinet Mekuriaw Tarekegn, Ochieng JW. "Production Systems, Genetic Diversity and Genes Associated with Prolificacy and Milk Production in Indigenous Goats of Sub-Saharan Africa: A Review." Open Journal of Animal Sciences. 2020;10(4):735-749.
S W, A K, S K, I M. "A Qualitative Analysis on the Clinical Experiences of Undergraduate Nursing Students in Kenya." Saudi Journal of Nursing and Health Care. 2020:293-238.
Okello JJ, Shiundu FM, Mwende J, Lagerkvist CJ, Nyikal RA, Muoki P, Mburu J, Low JW. "Quality and psychosocial factors influencing purchase of orange‐fleshed sweet potato bread." International Journal of Food Science and Technology. 2020. AbstractWebsite

This 2018 study, conducted in six Tusky's supermarkets in Nairobi, Kenya, combined the Just-About-Right, Penalty and Mean-End-Chain analyses to examine the quality and psychosocial factors influencing the purchase of a novel bread made from orange-fleshed sweet potato (OFSP), a biofortified crop, focusing on sixty-one male and eighty female urban OFSP bread buyers recruited at point of purchase. It finds that sensory and psychosocial factors drive purchasing decisions and that some of the bread's sensory characteristics are misaligned with consumers' expectations. It also finds that women and men's evaluations of the bread's characteristics are different, as are their motivations for purchase. However, good sensory attributes and the knowledge of the bread's nutritional value were key drivers. Some misaligned characteristics reveal levers for the reformulation of the bread and present opportunities for segmenting the market. Several other implications of the findings for policy and future improvement of the bread are discussed.

Gitari HI, Nyawade SO, Kamau S, Karanja NN, Gachene CKK, Raza MA, Maitra S, Schulte-Geldermann E. "Revisiting intercropping indices with respect to potato-legume intercropping systems.". 2020.
Ndegwa R, E Ayieta, Simiyu J, Odero N. "A Simplified Method for Parameter Determination of a Photovoltaic Module using Manufacturer’s data." Africa Journal of Physical Science. 2020;5:1-9.
Ndegwa, R., E Ayieta, Simiyu J, Odero N. "A Simplified Simulation Procedure and Analysis of a Photovoltaic Solar System Using a Single Diode Model." Journal of Power and Energy Engineering. 2020;8(9):65-93.
SO Pambo, Moindi SK, Nzimbi BM. "A study of eta-Ricci soliton on W_5-semi symmetric LP sasakian manifolfds." International Journal of Statistics and Applied Mathematics 2. 2020;5(5):25-29. AbstractWebsite

In this paper, we study ƞ-Ricci solitons on Lorentzian para-Sasakian manifold satisfying
R(ξ,X)•W_5(Y,Z)U=0 and W_5(ξ,X)•R(Y,Z)U=0 conditions.
We prove that on a Lorentzian para-Sasakian manifold (M,ξ,ƞ,g), the Ricci curvature tensor satisfying
any one of the given conditions, the existence of ƞ-Ricci soliton then implies that (M,g) is Einstein
manifold. We also conclude that in these cases, there is no Ricci soliton on M, with the potential vector
field ξ (the killing vector)

SO Pambo, Moindi SK, Nzimbi BM. "A study of eta-Ricci soliton on W_5-semi symmetric LP sasakian manifolfds." International Journal of Statistics and Applied Mathematics. 2020;5(5):25-29. AbstractWebsite

In this paper, we study ƞ-Ricci solitons on Lorentzian para-Sasakian manifold satisfying
R(ξ,X)•W_5(Y,Z)U=0 and W_5(ξ,X)•R(Y,Z)U=0 conditions.
We prove that on a Lorentzian para-Sasakian manifold (M,ξ,ƞ,g), the Ricci curvature tensor satisfying
any one of the given conditions, the existence of ƞ-Ricci soliton then implies that (M,g) is Einstein
manifold. We also conclude that in these cases, there is no Ricci soliton on M, with the potential vector
field ξ (the killing vector).

Warinda Enock, Dickson M. Nyariki, Stephen Wambua, Reuben M. Muasya, Hanjra. MA. "Sustainable development in East Africa: impact evaluation of regional agricultural development projects in Burundi, Kenya, Rwanda, Tanzania, and Uganda." Natural Resources Forum. 2020;44:3-39.
Owor RO, Bedane KG, Openda YI, Zühlke S, Derese S, Ong’amo G, Ong’amo G, Ndakala A, Spiteller M. "Synergistic anti-inflammatory activities of a new flavone and other flavonoids from Tephrosia hildebrandtii vatke." Natural Product Research. 2020:1-4. AbstractNatural Product Research

Description
A new flavone, named hildeflavone (1) along with 7 other known flavonoids were isolated from the aerial parts of Tephrosia hildebrandtii Vatke. Their characterisation was based on NMR and MS data analysis. The anti-inflammatory properties of the crude extract, isolated compounds and combination of the compounds were investigated in lipopolysaccharide (LPS)-stimulated peripheral blood mononuclear cells (PBMCs). Treatment of the LPS-stimulated PBMCs with the isolated flavonoids at a concentration of 100 µM significantly reduced the production of interleukins (IL-1β, IL-2 and IL-6), interferon-gamma (IFN-γ), granulocyte macrophage-colony stimulating factor (GM-CSF) and tumour necrosis factor-alpha (TNF-α). It was also found that the combination of a flavone and flavanones exhibited remarkable synergistic anti-inflammatory effects on the production of the cytokines.

Kinyungu TN, Muthomi JW, Subramanian S, Miano DW, Olubayo FM. "Transmission of viruses causing maize lethal necrosis disease through seed in commercial hybrids and effect on growth in the subsequent crop." Archives of Phytopathology and Plant Protection. 2020;DOI:10.1080/03235408.2020.1826720.
Nchiozem-Ngnitedema V-A, Omosa LK, Derese S, Tane P, Heydenreich M, Spiteller M, Ean-JeongSeo, Efferth T. "Two new flavonoids from Dracaena usambarensis Engl." Phytochemistry Letter. 2020;36:80-85.alex_et_al_2020.pdf
Nchiozem-Ngnitedem VA, Omosa LK, Derese S, Tane P, Heydenreich M, Spiteller M, Ean-JeongSeo, Efferth T. "Two new flavonoids from Dracaena usambarensis Engl." Phytochemistry Letters. 2020;36:80-85.alexe_et_al_2020_phytochemistry_letters.pdf
Galvin KA, Trevor Even, Robin S. Reid, Jesse Njoka, Joana Roque de Pinho, Philip Thornton, Saylor K. "Understanding Climate from the Ground Up: Knowledge of Environmental Changes in the East African Savannas." Changing Climate, Changing Worlds. 2020:221-242.
Vogel JP, Comrie‐Thomson L, Pingray V, Gadama L, Galadanci H, Goudar S, Rose Laisser, Lavender T, Lissauer D, Misra S, Pujar Y, Qureshi ZP, Amole T, Berrueta M, Dankishiya F, Gwako G, Homer CSE, Jobanputra J, Meja S, Nigri C, Mohaptra V, Osoti A, Roberti J, Solomon D, Suleiman M, Robbers G, Sutherland S, Vernekar S, Althabe F, Bonet M, Oladapo OT. "Usability, acceptability, and feasibility of the World Health Organization Labour Care Guide: A mixed‐methods, multicountry evaluation." Wiley Online Library . 2020. AbstractWebsite

Introduction
The World Health Organization’s (WHO) Labour Care Guide (LCG) is a “next‐generation” partograph based on WHO’s latest intrapartum care recommendations. It aims to optimize clinical care provided to women and their experience of care. We evaluated the LCG’s usability, feasibility, and acceptability among maternity care practitioners in clinical settings.

Methods
Mixed‐methods evaluation with doctors, midwives, and nurses in 12 health facilities across Argentina, India, Kenya, Malawi, Nigeria, and Tanzania. Purposively sampled and trained practitioners applied the LCG in low‐risk women during labor and rated experiences, satisfaction, and usability. Practitioners were invited to focus group discussions (FGDs) to share experiences and perceptions of the LCG, which were subjected to framework analysis.

Results
One hundred and thirty‐six practitioners applied the LCG in managing labor and birth of 1,226 low‐risk women. The majority of women had a spontaneous vaginal birth (91.6%); two cases of intrapartum stillbirths (1.63 per 1000 births) occurred. Practitioner satisfaction with the LCG was high, and median usability score was 67.5%. Practitioners described the LCG as supporting precise and meticulous monitoring during labor, encouraging critical thinking in labor management, and improving the provision of woman‐centered care.

Conclusions
The LCG is feasible and acceptable to use across different clinical settings and can promote woman‐centered care, though some design improvements would benefit usability. Implementing the LCG needs to be accompanied by training and supportive supervision, and strategies to promote an enabling environment (including updated policies on supportive care interventions, and ensuring essential equipment is available).

A. W, S. W, C. O’, S. F, van S. D. "Variation in the carbon footprint of milk production on smallholder dairy farms in Central Kenya, Journal of Cleaner Production." Journal of Cleaner Production 265:121780. 2020.
Fu W, Zhao X, Wang K, Chen Z, Leng K, Fu D, Song P, Wang H, Deng L, Pennycook SJ, others. "An anomalous magneto-optic effect in epitaxial indium selenide layers." Nano Letters. 2020;20:5330-5338. Abstract
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Dlamini CP, Khumalo T, Nkwanyana N, Mathunjwa-Dlamini TR, Macera L, Nsibandze BS, Kaplan L, Stuart-Shor EM. "Developing and implementing the family nurse practitioner role in Eswatini: implications for education, practice, and policy." Annals of Global Health. 2020;86. Abstract
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Wang C, Jiang X, Zhao G, Zhang M, Hsu CW, Peng B, Stone DA, Jiang L, Yang L. "Electromagnetically induced transparency at a chiral exceptional point." Nature Physics. 2020;16:334-340. Abstract
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Li Q, Zhao X, Deng L, Shi Z, Liu S, Wei Q, Zhang L, Cheng Y, Zhang L, Lu H, others. "Enhanced valley Zeeman splitting in Fe-doped monolayer MoS2." ACS nano. 2020;14:4636-4645. Abstract
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Lachenmeier DW, Teipel J, Scharinger A, Kuballa T, Walch SG, Grosch F, Bunzel M, Okaru AO, Schwarz S. "Fully automated identification of coffee species and simultaneous quantification of furfuryl alcohol using NMR spectroscopy." Journal of AOAC International. 2020;103:306-314. Abstract
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Lin K-Q, Holler J, Bauer JM, Scheuck M, Peng B, Korn T, Bange S, Lupton JM, Schüller C. "Large-scale mapping of moir$\backslash$'e superlattices by Raman imaging of interlayer breathing mode and moir$\backslash$'e phonons." arXiv preprint arXiv:2012.13820. 2020. Abstract
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Guo K, Deng B, Liu Z, Gao C, Shi Z, Bi L, Zhang L, Lu H, Zhou P, Zhang L, others. "Layer dependence of stacking order in nonencapsulated few-layer CrI3." Science China Materials. 2020;63:413-420. Abstract
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Shi Z, Muhammad S, Deng L, Liu Z, Bi L, Zhang L, Zhang L, Zhou P, Chen H, Lu H, others. "Magnetic-brightening and control of dark exciton in CsPbBr3 perovskite." Science China Materials. 2020;63:1503-1509. Abstract
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Kanduma EG, Emery D, Githaka NW, Nguu EK, Bishop RP, Šlapeta J. "Molecular evidence confirms occurrence of Rhipicephalus microplus Clade A in Kenya and sub-Saharan Africa." Parasites & vectors. 2020;13:1-15. Abstract
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Liu Z, Guo K, Hu G, Shi Z, Li Y, Zhang L, Chen H, Zhang L, Zhou P, Lu H, others. "Observation of nonreciprocal magneto-optical scattering in nonencapsulated few-layered CrI3." arXiv preprint arXiv:2008.12896. 2020. Abstract
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Liu Z, Guo K, Hu G, Shi Z, Li Y, Zhang L, Chen H, Zhang L, Zhou P, Lu H, others. "Observation of nonreciprocal magnetophonon effect in nonencapsulated few-layered CrI3." Science advances. 2020;6:eabc7628. Abstract
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Muchira JM, Gona PN, Mogos MF, Stuart-Shor E, Leveille SG, Piano MR, Hayman LL. "Parental cardiovascular health predicts time to onset of cardiovascular disease in offspring." European Journal of Preventive Cardiology. 2020. Abstract
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Kerry VB, Ahaisibwe B, Malewezi B, Ngoma D, Daoust P, Stuart-Shor E, Mannino CA, Day D, Foradori L, Sayeed SA. "Partnering to build human resources for health capacity in Africa: a descriptive review of the global health service partnership’s innovative model for health professional education and training from 2013-2018." International Journal of Health Policy and Management. 2020. Abstract
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Kivata MW, Mbuchi M, Eyase F, Bulimo WD, Kyanya CK, Oundo V, Mbinda WM, Sang W, Andagalu B, Soge OO, McClelland RS, Distelhorst J. "Plasmid mediated penicillin and tetracycline resistance among Neisseria gonorrhoeae isolates from Kenya." BMC Infectious Diseases. 2020;20. Abstract
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Shang B, Zhang X, Ji R, Wang Y, Hu H, Peng B, Deng Z. "Preparation of colloidal polydopamine/Au hollow spheres for enhanced ultrasound contrast imaging and photothermal therapy." Materials Science and Engineering: C. 2020;106:110174. Abstract
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Peng B, Zhang H, Chen W, Hou B, Qiu Z-J, Shao H, Zhu H, Monserrat B, Fu D, Weng H, others. "Sub-picosecond photo-induced displacive phase transition in two-dimensional MoTe2." npj 2D Materials and Applications. 2020;4:1-8. Abstract
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Shang B, Xu M, Zhi Z, Xi Y, Wang Y, Peng B, Li P, Deng Z. "Synthesis of sandwich-structured silver@ polydopamine@ silver shells with enhanced antibacterial activities." Journal of Colloid and Interface Science. 2020;558:47-54. Abstract
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Muchira JM, Gona PN, Mogos MF, Stuart-Shor E, Leveille SG, Piano MR, Hayman LL. "Temporal trends and familial clustering of ideal cardiovascular health in parents and offspring over the life course: an investigation using the Framingham Heart Study." Journal of the American Heart Association. 2020;9:e016292. Abstract
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Okaru AO, Scharinger A, de Rezende TR, Teipel J, Kuballa T, Walch SG, Lachenmeier DW. "Validation of a quantitative proton nuclear magnetic resonance spectroscopic screening method for coffee quality and authenticity (NMR coffee screener)." Foods. 2020;9:47. Abstract
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2019
Sila MJ, Nyambura MI, Abong’o DA, Mwaura FB, Iwuoha E. "Biosynthesis of Silver Nanoparticles from Eucalyptus Corymbia Leaf Extract at Optimized Conditions.". In: Nano Hybrids and Composites Vol. 25. Vol. 25. South Africa; 2019:. Abstract

Abstract:

This study reports the biosynthesis of narrow range diameter silver nanoparticles at optimum conditions using Eucalyptus corymbia as a reducing and stabilizing agent. Optimal conditions for biosynthesis of silver nanoparticles (AgNPs) were found to be; an extraction temperature of 90°C, pH of 5.7 a Silver Nitrate concentration of 1mM and AgNO3 to plant extract ratio of 4:1. UV-Visible spectroscopy monitored the formation of colloidal AgNPs. The UV-Visible spectrum showed a peak around 425 nm corresponding to the Plasmon absorbance of the AgNPs. The size and shape characterization of the AgNPs was done using Transmission Electron Microscopy (TEM) techniques which revealed narrow range diameter (18-20 nm), almost monodispersed AgNPs, spherical in nature and with minimal agglomeration. Energy Dispersive X-ray (EDX) results showed the presence of two peaks at 3.0 and 3.15 keV in the silver region. The Fourier Transform Infrared-Spectra (FTIR) of the plant extract and the AgNPs gave rise to vibrational peaks at 3260 and 1634 wavenumbers which are due to the presence of OH and –C=C-functional groups respectively.

Onikeku O, Shitote SM, Mwero JN, Adedeji AA. "Comparative Analysis of Compressive Strength of Bamboo Leaf Ash and Bagasse Ash Concretes.". In: Machakos University 2nd Annual International Conference. Machakos, Kenya; 2019.
Ampt FH, Lim MSC, Agius PA, Chersich MF, Manguro G, Gichuki CM, Stoové M, Temmerman M, Jaoko W, Hellard M, Gichangi P, Luchters S. "Use of long-acting reversible contraception in a cluster-random sample of female sex workers in Kenya." Int J Gynaecol Obstet. 2019. Abstract

To assess correlates of long-acting reversible contraceptive (LARC) use, and explore patterns of LARC use among female sex workers (FSWs) in Kenya.

Sabo MC, Richardson BA, Lavreys L, Martin HL, Jaoko W, Mandaliya K, Baeten JM, Overbaugh J, McClelland SR. "Does bacterial vaginosis modify the effect of hormonal contraception on HIV seroconversion." AIDS. 2019;33(7):1225-1230. Abstract

A recent study of HIV serodiscordant couples found that depot medroxyprogesterone acetate (DMPA) and oral contraceptive pills (OCPs) were associated with increased HIV risk in the presence, but not in the absence, of bacterial vaginosis. We assessed whether bacterial vaginosis is an effect modifier of the association between hormonal contraception and HIV seroconversion in female sex workers (FSWs) in Mombasa, Kenya.

Dimova I, Karthik S, Makanya A, Hlushchuk R, Semela D, Volarevic V, Djonov V. "SDF-1/CXCR4 signalling is involved in blood vessel growth and remodelling by intussusception." J. Cell. Mol. Med.. 2019;23(6):3916-3926. Abstract

The precise mechanisms of SDF-1 (CXCL12) in angiogenesis are not fully elucidated. Recently, we showed that Notch inhibition induces extensive intussusceptive angiogenesis by recruitment of mononuclear cells and it was associated with increased levels of SDF-1 and CXCR4. In the current study, we demonstrated SDF-1 expression in liver sinusoidal vessels of Notch1 knockout mice with regenerative hyperplasia by means of intussusception, but we did not detect any SDF-1 expression in wild-type mice with normal liver vessel structure. In addition, pharmacological inhibition of SDF-1/CXCR4 signalling by AMD3100 perturbs intussusceptive vascular growth and abolishes mononuclear cell recruitment in the chicken area vasculosa. In contrast, treatment with recombinant SDF-1 protein increased microvascular density by 34% through augmentation of pillar number compared to controls. The number of extravasating mononuclear cells was four times higher after SDF-1 application and two times less after blocking this pathway. Bone marrow-derived mononuclear cells (BMDC) were recruited to vessels in response to elevated expression of SDF-1 in endothelial cells. They participated in formation and stabilization of pillars. The current study is the first report to implicate SDF-1/CXCR4 signalling in intussusceptive angiogenesis and further highlights the stabilizing role of BMDC in the formation of pillars during vascular remodelling.

Lokken EM, Manguro GO, Abdallah A, Ngacha C, Shafi J, Kiarie J, Jaoko W, Srinivasan S, Fiedler TL, Munch MM, Fredricks DN, McClelland SR, Balkus JE. "Association between vaginal washing and detection of by culture and quantitative PCR in HIV-seronegative Kenyan women: a cross-sectional analysis." Sex Transm Infect. 2019. Abstract

Vaginal washing has been associated with reductions in cultivable and an increased risk of both bacterial vaginosis (BV) and HIV infection. The effect of vaginal washing on the quantity of individual species is not well characterised. This analysis tested the hypothesis that vaginal washing would be associated with a lower likelihood of spp. detected by both culture and quantitative PCR (qPCR).

Lokken EM, Richardson BA, John Kinuthia, James N Kiarie, Mwinyikai K, Abdalla A, Jaoko W, Mandaliya K, Shafi J, Scott McClelland R. "A Prospective Cohort Study of the Association Between Body Mass Index and Incident Bacterial Vaginosis." Sex Transm Dis. 2019;46(1):31-36. Abstract

Some studies suggest that higher body mass index is associated with increased susceptibility to bacterial vaginosis (BV), but results are conflicting.

Amzati GS, Djikeng A, Odongo DO, Nimpaye H, Sibeko KP, Muhigwa J-BB, Madder M, Kirschvink N, Marcotty T. "Genetic and antigenic variation of the bovine tick-borne pathogen Theileria parva in the Great Lakes region of Central Africa." Parasit Vectors. 2019;12(1):588. Abstract

Theileria parva causes East Coast fever (ECF), one of the most economically important tick-borne diseases of cattle in sub-Saharan Africa. A live immunisation approach using the infection and treatment method (ITM) provides a strong long-term strain-restricted immunity. However, it typically induces a tick-transmissible carrier state in cattle and may lead to spread of antigenically distinct parasites. Thus, understanding the genetic composition of T. parva is needed prior to the use of the ITM vaccine in new areas. This study examined the sequence diversity and the evolutionary and biogeographical dynamics of T. parva within the African Great Lakes region to better understand the epidemiology of ECF and to assure vaccine safety. Genetic analyses were performed using sequences of two antigen-coding genes, Tp1 and Tp2, generated among 119 T. parva samples collected from cattle in four agro-ecological zones of DRC and Burundi.

Cheng C-Y, Wang N, Wong TY, Congdon N, He M, Wang YX, Braithwaite T, Casson RJ, Cicinelli MV, Das A, Flaxman SR, Jonas JB, Keeffe JE, Kempen JH, Leasher J, Limburg H, Naidoo K, Pesudovs K, Resnikoff S, Silvester AJ, Tahhan N, Taylor HR, Bourne RRA, of the of Study VLEGGBD. "Prevalence and causes of vision loss in East Asia in 2015: magnitude, temporal trends and projections." Br J Ophthalmol. 2019. AbstractWebsite

BACKGROUND: To determine the prevalence and causes of blindness and vision impairment (VI) in East Asia in 2015 and to forecast the trend to 2020.
METHODS: Through a systematic literature review and meta-analysis, we estimated prevalence of blindness (presenting visual acuity <3/60 in the better eye), moderate-to-severe vision impairment (MSVI; 3/60≤presenting visual acuity <6/18), mild vision impairment (mild VI: 6/18≤presenting visual acuity <6/12) and uncorrected presbyopia for 1990, 2010, 2015 and 2020. A total of 44 population-based studies were included.
RESULTS: In 2015, age-standardised prevalence of blindness, MSVI, mild VI and uncorrected presbyopia was 0.37% (80% uncertainty interval (UI) 0.12%-0.68%), 3.06% (80% UI 1.35%-5.16%) and 2.65% (80% UI 0.92%-4.91%), 32.91% (80% UI 18.72%-48.47%), respectively, in East Asia. Cataract was the leading cause of blindness (43.6%), followed by uncorrected refractive error (12.9%), glaucoma, age-related macular degeneration, corneal diseases, trachoma and diabetic retinopathy (DR). The leading cause for MSVI was uncorrected refractive error, followed by cataract, age-related macular degeneration, glaucoma, corneal disease, trachoma and DR. The burden of VI due to uncorrected refractive error, cataracts, glaucoma and DR has continued to rise over the decades reported.
CONCLUSIONS:Addressing the public healthcare barriers for cataract and uncorrected refractive error can help eliminate almost 57% of all blindness cases in this region. Therefore, public healthcare efforts should be focused on effective screening and effective patient education, with access to high-quality healthcare.

Hassan S, Skilton RA, Pelle R, Odongo D, Bishop RP, Ahmed J, Seitzer U, Bakheit M, HASSAN SM, El Hussein AM. "Assessment of the prevalence of Theileria lestoquardi in sheep from the Sudan using serological and molecular methods." Prev Vet Med. 2019;169:104697. Abstract

Malignant theileriosis of sheep and goats caused by Theileria lestoquardi is considered to be among the most important tick borne diseases in the Sudan. Information on the prevalence of the disease in different parts of the Sudan is limited. The purpose of this study was to estimate the prevalence of the disease in five states of the Sudan using molecular and serological assays. A total of 393 blood and serum samples from clinically asymptomatic sheep were analysed using nested reverse line blot (nRLB) and loop mediated isothermal amplification (LAMP), as well as an enzyme-linked immunosorbent assay (ELISA). The results indicated a sero-prevalence of 33.8% while RLB and LAMP assays revealed molecular prevalences of 29.5 and 22.6% respectively. The prevalence of Theileria lestoquardi varied significantly according to the geographical origin of the infected animals, whereas age and gender did not have a significant effect. RLB data indicated that T. lestoquardi usually occurred as a co-infection with the non-pathogenic Theileria ovis. Using RLB as a gold standard, a sensitivity of 68.1% and a specificity of 96.4% were recorded for LAMP and a sensitivity of 75.9% and a specificity of 83.8% for ELISA. The Kappa coefficient between nRLB and LAMP indicated a significant level of agreement (0.692), but only moderate concordance (0.572) between nRLB and ELISA. The results of the present study confirm and extend earlier findings regarding the widespread of T. lestoquardi infections in sheep in the Sudan. The data provide evidence that should enable the veterinary authorities to deploy appropriate control measures.

Kivata MW, Mbuchi M, Eyase FL, Bulimo WD, Kyanya CK, Oundo V, Muriithi SW, Andagalu B, Mbinda WM, Soge OO, McClelland SR, Sang W, Mancuso JD. "gyrA and parC mutations in fluoroquinolone-resistant Neisseria gonorrhoeae isolates from Kenya." BMC Microbiol.. 2019;19(1):76. Abstractkivata_et_al-2019-bmc_microbiology.pdf

Phenotypic fluoroquinolone resistance was first reported in Western Kenya in 2009 and later in Coastal Kenya and Nairobi. Until recently gonococcal fluoroquinolone resistance mechanisms in Kenya had not been elucidated. The aim of this paper is to analyze mutations in both gyrA and parC responsible for elevated fluoroquinolone Minimum Inhibitory Concentrations (MICs) in Neisseria gonorrhoeae (GC) isolated from heterosexual individuals from different locations in Kenya between 2013 and 2017.

Attardo GM, Abd-Alla AMM, Acosta-Serrano A, Allen JE, Bateta R, Benoit JB, Bourtzis K, Caers J, Caljon G, Christensen MB, Farrow DW, Friedrich M, Hua-Van A, Jennings EC, Larkin DM, Lawson D, Lehane MJ, Lenis VP, Lowy-Gallego E, Macharia RW, Malacrida AR, Marco HG, Masiga D, Maslen GL, Matetovici I, Meisel RP, Meki I, Michalkova V, Miller WJ, Minx P, Mireji PO, Ometto L, Parker AG, Rio R, Rose C, Rosendale AJ, Rota-Stabelli O, Savini G, Schoofs L, Scolari F, Swain MT, Takáč P, Tomlinson C, Tsiamis G, Van Den Abbeele J, Vigneron A, Wang J, Warren WC, Waterhouse RM, Weirauch MT, Weiss BL, Wilson RK, Zhao X, Aksoy S. "Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes." Genome Biol. 2019;20(1):187. Abstract

Tsetse flies (Glossina sp.) are the vectors of human and animal trypanosomiasis throughout sub-Saharan Africa. Tsetse flies are distinguished from other Diptera by unique adaptations, including lactation and the birthing of live young (obligate viviparity), a vertebrate blood-specific diet by both sexes, and obligate bacterial symbiosis. This work describes the comparative analysis of six Glossina genomes representing three sub-genera: Morsitans (G. morsitans morsitans, G. pallidipes, G. austeni), Palpalis (G. palpalis, G. fuscipes), and Fusca (G. brevipalpis) which represent different habitats, host preferences, and vectorial capacity.

Katz MA, Marangu D, Attia EF, Bauwens J, Bont LJ, Bulatovic A, Crane J, Doroshenko A, Ebruke BE, Edwards KM, Fortuna L, Jagelaviciene A, Joshi J, Kemp J, Kovacs S, Lambach P, Lewis KDC, Ortiz JR, Simões EAF, Turner P, Tagbo BN, Vaishnavi V, Bonhoeffer J. "Acute wheeze in the pediatric population: Case definition & guidelines for data collection, analysis, and presentation of immunization safety data." Vaccine. 2019;37(2):392-399.
Kamau F, Strijdom H, Mwangi P, Blackhurst D, Imperial E, Salie R. "Antiretroviral drug-induced endothelial dysfunction is improved by dual PPARα/γ stimulation in obesity.". 2019;121:106577. AbstractWebsite

Obesity rates are rising in HIV-infected populations; however, the putative role of highly active antiretroviral therapy (HAART) in the development of endothelial and cardiovascular derangements in the presence of pre-existing overweight/obesity is unclear. Although dual peroxisome proliferator-activated receptors-alpha/gamma (PPARα/γ) stimulation mitigates HAART-induced metabolic dysfunction, vascular effects are unresolved. To investigate whether HAART induces vascular dysfunction in obesity and to explore the underlying mechanisms of PPARα/γ stimulation, male Wistar rats were placed on a high-calorie diet for 16 weeks. After 10 weeks, HAART (lopinavir/ritonavir, azidothymidine/lamivudine) with/without PPARα/γ agonist, Saroglitazar, was administered daily for six weeks. Excised thoracic aorta rings were subjected to isometric tension studies and Western blot measurements. HAART+Saroglitazar-treated obese animals recorded lower adiposity indices (4.3 ± 0.5%) vs. HAART only-treated obese rats (5.6 ± 0.3%; p < .01). Maximum acetylcholine-induced vasorelaxation (Rmax), was lower in obese+HAART group (76.10 ± 3.58%) vs. obese control (101.40 ± 4.75%; p < .01). However, Rmax was improved in obese+ HAART+Saroglitazar (101.00 ± 3.12%) vs. obese+HAART rats (p < .001). The mean LogEC50 was improved in obese+HAART+Saroglitazar vs. obese+HAART group; p = .003. Improved endothelial function in obese+ HAART+Saroglitazar group was associated with upregulation of eNOS, PKB/Akt and downregulated p22-phox expression vs. obese+HAART group. Therefore, PPARα/γ stimulation attenuated HAART-induced endothelial dysfunction by upregulating vasoprotective eNOS, PKB/Akt signaling and downregulating pro-oxidative p22-phox expression.

Simiyu MT, Nyongesa FW, Aduda BO, Birech Z, Mwebaze G. "2. Mary T. Simiyu, Francis W. NyongesaApplication of An Organic Plant-Derived Binder in the Fabrication of Diatomaceous Earth Waste-Based Membranes for Water Purification Systems.". In: 10th International Conference of the African Materials Research Society (AMRS2019). Arusha, Tanzania,; 2019.
Sorensen, Olago, D. O., Dulo, Kanoti, Gaye, Faye, Pouye, Owor. "Real-time indication of faecally contaminated drinking water with fluorescence spectroscopy: towards understanding the causation.". In: 10th International Groundwater Quality Conference (GQ 2019). Liège, Belgium; 2019.
Davison B, Ongaro J, Szendr\H oi B. "Enumerating coloured partitions in 2 and 3 dimensions." Mathematical Proceedings of the Cambridge Philosophical Society. 2019;DOI=10.1017/S0305004119000252:1-27. Abstract

n/a

Zalasiewicz J, Waters CN, Williams M, Summerhayes CP, Odada E, Wagreich M, Draganits E, Edgewor M. "7 The Stratigraphic Boundary of the Anthropocene.". In: The Anthropocene as a Geological Time Unit: A Guide to the Scientific Evidence and Current Debate. Cambridge University Press; 2019. Abstract

Here we outline the basis on which a formal proposal should be made for potential inclusion of the Anthropocene in the Geological Time Scale, examining the scale and rate of human change to the Earth System to help recognise the point at which anthropogenic impacts became of sufficient scale to allow discrimination of the Anthropocene as a geological unit. This examination covers such factors as impacts from early hominin species, the first human artefacts, early ecosystem modification through agriculture, deforestation, the domestication of animals, urbanisation, metal mining and smelting and early globalisation. The Industrial Revolution, starting in the UK in the 18th century, and the global Great Acceleration of the mid-20th century, are investigated, as both provide popular narratives that explain the Earth System changes indicative of the Anthropocene, with the latter producing the near-synchronous stratigraphic signals most consistent with an effective geological time boundary. We assess which hierarchical level–age, epoch, period, era or eon–seems most suitable for the Anthropocene, and suggest that epoch (= series) level is conservative and appropriate. The Anthropocene might be defined via a Global Standard Stratigraphic Age or a Global boundary Stratotype Section and Point, with the latter being most appropriate. Finally, we assess the kinds of geological environments, including anoxic marine basins, annually banded coral and bivalve skeletons, estuaries and deltas, lake floors, peat mires, anthropogenic deposits, polar ice, speleothems and tree rings, in which such a physical reference level might be placed.

Ismail LW, ZP Q, SB O. "The acceptability of HIV testing among women receiving post abortion care." South Sudan Medical Journal. 2019;12(3):101-105. AbstractWebsite

Introduction: In South Sudan few women have heard about the HIV. The prevalence of HIV infection in the country is 2.6%. Post abortion care (PAC) accounts for over 50% of all gynaecological admissions at the Juba Teaching Hospital (JTH). HIV testing is not routinely offered as part of PAC services.

Objective: To determine factors associated with acceptability of HIV testing among women receiving PAC at JTH.

Methods: This was a cross-sectional study, conducted at the Gynaecological Unit of JTH. Three hundred and forty patients were interviewed using a structured questionnaire.

Results: The mean age of the participants was 24.7 years with 50.5% aged <25years, 31.5% were employed, and 31.8% had no formal education. Acceptability of HIV testing was 70.9% and the prevalence of HIV was 2.7%. The most common reason for not accepting, was the belief, based on previous results, that they were HIV negative. Patients aged ≥25 years and those with primary and secondary education were twice as likely to accept HIV testing than those <25 years and those with no formal education, respectively. Employment status, religion and marital status were not statistically associated with acceptability of HIV testing. Patients previously tested for HIV were more likely to accept testing.

Conclusion: Routine HIV testing should be integrated into PAC services with efforts to increase awareness of HIV and importance of testing

Key words: HIV, abortion, post-abortion care, South Sudan

Sirma AJ, Makita K, Grace D, Senerwa D, Lindahl JF. "Aflatoxin exposure from milk in rural Kenya and contribution to the risk of liver cancer." Toxins. 2019;11:469.
Gitari HI, Shadrack N, Kamau S, Karanja NN, Gachene CKK, Schulte-Geldermann E. "Agronomic assessment of phosphorus efficacy for potato (Solanum tuberosum L) under legume intercrops.". 2019.
DN Kareithi, Salifu D, N Owuor, Subramanian S, Tonnang EZH. "An algorithm for data reconstruction from published articles–Application on insect life tables." Cogent Mathematics & Statistics. 2019;6(1):1701377. AbstractWebsite

Data collection in life table experiments is generally time-consuming and costly such that data reconstruction of published information provides an avenue to access the original data for purposes of further investigation. In this paper, we present an algorithm that reconstructs life table raw data using a summary of results from published articles. We present the steps of the development and implementation (in the R computer language) of the algorithm, its scope of application, assumptions, and limitations. Statistical background of the algorithm is also presented. The developed algorithm was then applied to reconstruction of life table data of two insect species, Chilo partellus and Busseola fusca, from published information. Welch’s two-sample t-test was applied to test the difference between the original and reconstructed data of the insect life stages. C. Partellus results were not significantly different, but, for B. fusca, pupa development time, and larva and pupa development rate were significantly different at the 95% confidence level. It is concluded that the algorithm could be used to reconstruct original data sets from cohort life table data sets of insects, given published information and sample sizes.

Susan Gachau, Nelson Owuor, NJAGI EDMUNDNJERU, Ayieko P, English M. "Analysis of Hierarchical Routine Data With Covariate Missingness: Effects of Audit & Feedback on Clinicians' Prescribed Pediatric Pneumonia Care in Kenyan Hospitals." Frontiers in public health. 2019;7( ):198. AbstractWebsite

Background:
Routine clinical data are widely used in many countries to monitor quality of care. A limitation of routine data is missing information which occur due to lack of documentation of care processes by health care providers, poor record keeping or limited health care technology at facility level. Our objective was to address missing covariates while properly accounting for hierarchical structure in routine paediatric pneumonia care.
Methods:
We analysed routine data collected during a cluster randomized trial to investigating the effect of audit and feedback (A&F) over time on inpatient pneumonia care among children admitted in 12 Kenyan hospitals between March and November 2016. Six hospitals in the intervention arm received enhance A&F on classification and treatment of pneumonia cases in addition to a standard A&F report on general inpatient paediatric care. The remaining six in control arm received standard A&F alone. We derived and analysed a composite outcome known as Paediatric Admission Quality of Care (PAQC) score. In our analysis, we adjusted for patients, clinician and hospital level factors. Missing data occurred in patient and clinician level variables. We did multiple imputation of missing covariates within the joint model imputation framework. We fitted proportion odds random effects model and generalized estimating equation (GEE) models to the data before and after multilevel multiple imputation.

Bebora L.C, Gitao CG, P.M M, Mobegi VA, Shumbusho B, Iraguha B. "Assessment of bacterial contamination and milk handling practices along the raw milk market chain in the North-Western region of Rwanda." African Journal of Microbiology Research. 2019;13(29):640-648.abstract.pdf
Shem Otoi Sam, Pokhariyal GP, hir Moses M Manene, Kipchirc IC. "Autoregressive distributed lag cointegration analysis of youth unemployment in Kenya." International Journal of Statistics and Applied Mathematics. 2019;4(1):29-41. AbstractWebsite

In this paper we consider cointegration analysis in an autoregressive distributed lag (ARDL) structure. First, logarithmic transformation is performed on the series to reduce outlier effects and have elasticity interpreted in terms of percentage. Second, the variables are tested for stationarity using Augmented Dickey-Fuller test. Third, the Johansen Cointegration test is carried out to examine cointegration of the series. Fourth, cointegrated dynamic ARDL model is estimated using ordinary least squares (OLS) and effects of variables and their lags interpreted. The results indicate that Gross Domestic Product (GDP) and its two-year lag are the only ones having negative effect on youth unemployment, that is, one unit increase in GDP and GDP two-year lag reduce youth unemployment by 0.207922% and 0.2052705% respectively. Also, one unit increase in External Debt (ED) and ED two-year lag reduce youth unemployment by 0.07303% and 0.009116% respectively. Furthermore, unit increase in one-year lag of youth literacy rate is the only one which reduces youth unemployment by 0.0892691%; one-year and three-year lag of population (POP) reduce youth unemployment by 0.2590455% and 4.3093119% respectively. The Foreign Direct Investment (FDI) and Private Investment (PI) do not have significant effects on youth unemployment. In the long run, increase in GDP causes increase in youth unemployment by 0.09148447%. The long run result explains that GDP growth in the country is “jobless growth” mainly in less labour intensive sectors

Shem Otoi Sam, Pokhariyal GP, Manene MM, Isaac C Kipchirchir. "Autoregressive distributed lag cointegration analysis of youth unemployment in Kenya." International Journal of Statistics and Applied Mathematics. 2019;4(1): 29-41. AbstractWebsite

In this paper we consider cointegration analysis in an autoregressive distributed lag (ARDL) structure. First, logarithmic transformation is performed on the series to reduce outlier effects and have elasticity interpreted in terms of percentage. Second, the variables are tested for stationarity using Augmented Dickey-Fuller test. Third, the Johansen Cointegration test is carried out to examine cointegration of the series. Fourth, cointegrated dynamic ARDL model is estimated using ordinary least squares (OLS) and effects of variables and their lags interpreted. The results indicate that Gross Domestic Product (GDP) and its two-year lag are the only ones having negative effect on youth unemployment, that is, one unit increase in GDP and GDP two-year lag reduce youth unemployment by 0.207922% and 0.2052705% respectively. Also, one unit increase in External Debt (ED) and ED two-year lag reduce youth unemployment by 0.07303% and 0.009116% respectively. Furthermore, unit increase in one-year lag of youth literacy rate is the only one which reduces youth unemployment by 0.0892691%; one-year and three-year lag of population (POP) reduce youth unemployment by 0.2590455% and 4.3093119% respectively. The Foreign Direct Investment (FDI) and Private Investment (PI) do not have significant effects on youth unemployment. In the long run, increase in GDP causes increase in youth unemployment by 0.09148447%. The long run result explains that GDP growth in the country is “jobless growth” mainly in less labour intensive sectors.

Ndwigah S, Stergachis A, Abuga K, Mugo H, Kibwage I. "Availability and Prices of Antimalarials and Staffing Levels in Health Facilities in Embu County, Kenya." East Cent. Afr. J. Pharm. Sci.. 2019;22(1):26-34. Abstract

Effective treatment of malaria relies on the availability of quality medicines while pricing is a major determinant of affordability. In addition, adequate numbers of competent staff of different cadres is essential for a well-functioning health system and effective health service delivery. The aim of the study was to determine the availability and prices of antimalarial medicines as well as staffing levels in healthcare facilities located in Embu County, Kenya. Antimalarials were sampled from 11 public (government owned) facilities, 29 private pharmacies, 5 private-for-profit and 3 not-for-profit mission health facilities in May-June 2014. The majority of public facilities (91%) had artemether-lumefantrine (AL) tablets in stock. Government and mission facilities did not stock second line antimalarials or sulfonamide-pyrimethamine (SP). All public facilities provided antimalarials free-of-charge to patients. Private pharmacies stocked a wider variety of antimalarials. The facilities studied were stocked with recommended antimalarials both in the private and public domains. No oral artemisinin monotherapies were encountered during the study. Only 45% percent of public facilities employed pharmacists. Of the remaining facilities, 27% employed pharmaceutical technologists while in the rest of the facilities pharmaceuticals were in the custody of nurses. Notably, none of the private-for-profit or mission facilities had pharmacists employed in their establishments; one facility employed a pharmaceutical technologist, while the rest were staffed by nurses. The number of private pharmacies superintended by pharmacists and pharmaceutical technologists were 7 (24%) and 22 (76%), respectively.

Ndwigah S, Stergachis A, Abuga K, Mugo H, Kibwage I. "Availability and prices of antimalarials and staffing levels in health facilities in Embu County, Kenya." East and Central African Journal of Pharmaceutical Sciences. . 2019;22:26-34.
Sila MJ, Nyambura MI, Abong'o DA, Mwaura FB, Iwuoha E. "Biosynthesis of Silver Nanoparticles from Eucalyptus Corymbia Leaf Extract at Optional Conditions." Nanohybrids and Composites. 2019;25:32-45.
Chanzu HA, Onyari JM, Shiundu PM. "Brewers’ spent grain in adsorption of aqueous Congo Red and malachite Green dyes: Batch and continuous flow systems." Journal of hazardous materials. 2019;380:120897. Abstract

Abstract

Sorption of Congo Red (CR) and Malachite Green (MG) dyes currently used in pigments and clothing industries were investigated using brewers’ spent grain (BSG) from a local brewery. Adsorption increased with a higher adsorbent weight and lower colorant concentrations. Accumulation of CR and MG was optimal at acidic pH and neutral pH respectively. Sorption decreased with an increase in temperature signifying an exothermic process. Batch adsorption data fitted better to Langmuir adsorption isotherm model and pseudo-second-order kinetics. Maximum monolayer coverage capacities (
were found to be 2.55 mg/g for MG and 36.5 mg/g for CR dye. Column studies using BSG were also conducted for both dyes. Fixed bed breakthrough was fast with an increase in dye concentration, adsorbent surface area, and flow rate and with a decrease in column depth. BSG are effective, simple in design and inexpensive adsorbing material from renewable sources.

Chanzu HA, Onyari JM, Shiundu PM. "Brewers’ spent grain in adsorption of aqueous Congo Red and malachite Green dyes: Batch and continuous flow systems." Journal of hazardous materials. 2019;380:120897. AbstractJournal article

Description

Abstract Sorption of Congo Red (CR) and Malachite Green (MG) dyes currently used in pigments and clothing industries were investigated using brewers’ spent grain (BSG) from a local brewery. Adsorption increased with a higher adsorbent weight and lower colorant concentrations. Accumulation of CR and MG was optimal at acidic pH and neutral pH respectively. Sorption decreased with an increase in temperature signifying an exothermic process. Batch adsorption data fitted better to Langmuir adsorption isotherm model and pseudo-second-order kinetics. Maximum monolayer coverage capacities (Q O)) were found to be 2.55 mg/g for MG and 36.5 mg/g for CR dye. Column studies using BSG were also conducted for both dyes. Fixed bed breakthrough was fast with an increase in dye concentration, adsorbent surface area, and flow rate and with a decrease in column depth. BSG are effective, simple in design …

Odongo MA, Siriba DN. "Cadastral Data Model for an Informal Settlement: Case Study of Huruma, Nairobi – Kenya." African Journal of Land Policy and Geospatial Sciences. 2019;2(2):57-67.
Stephen AO, Joyce KGN, Hellen N, Alex WN, Jared N’auO. "CHARACTERISATION AND ADSORPTION OF HEAVY METALS IN INDUSTRIAL EFFLUENT FROM PAINT AND COATING INDUSTRIES IN NAIROBI, KENYA." International Journal of Engineering Applied Sciences and Technology. 2019;4(5):41-46. Abstractabstract.pdfInternational Journal of Engineering Applied Sciences and Technology

Description
A study was conducted to estimate current status of physico-chemical characteristics of effluents emanating from three paint factories within the main industrial area of Nairobi County. The effluents were analysed for temperature, pH, oil and grease, total suspended solids (TSS), chemical oxygen demand (COD), total phosphorus, total nitrogen, total sulphur and heavy metal ions and compared to Kenyan effluent discharge standards. The results were as follows: pH 6.48-6.89, temperature 28.07-28.30 oC, COD 916.77-1881.20 mg/L, total phosphorus 145.00-149.32 mg/L, TSS 6382.33-7395.33 mg/L, oil and grease 3525.00-6374.33 mg/L, total sulphur 72.62-73.41 mg/L, total nitrogen 1586.67-4442.67 mg/L. Heavy metal concentrations were 3.03-4.18 mg/L, 2.07-3.04 mg/L and 5.38-17.21 mg/L respectively for cadmium, chromium and lead. Adsorbent was made from waste rubber tyres and tested for its suitability in removing three heavy metal ions namely cadmium, lead and chromium from the effluent samples by varying adsorbent dosage, pH and contact time.

H. NGUETTIJ, K. IJ, W. OM, S. MITEMAE, F. MBACHAMW, J. WANG’OMBE. "Consumer’s Awareness of the presence of pathogenic bacteria and pesticide Residues on tomatoes sold in Nairobi." African Journal of Agricultural Research . 2019;14(35):2146-2158.
Nyawade SO, Gachene CKK, Karanja NN, Gitari HI, Schulte-Geldermann E, Parker ML. "Controlling soil erosion in smallholder potato farming systems using legume intercrops.". 2019.
Shah P, Ayiemba E. "Convention on biological diversity and rural-urban connections with reference to Kenya." International Journal of Research in Environmental Studies. 2019;6:14-26.
Sewe S, Ngare P, Weke P. "Credit Scoring with Ego-Network Data." Journal of Mathematical Finance. 2019;9(3):522-534. AbstractWebsite

This article investigates a stochastic filtering problem whereby the bor-rower’s hidden credit quality is estimated using ego-network signals. The hidden credit quality process is modeled as a mean reverting Ornstein-Ulehnbeck process. The lender observes the borrower’s behavior modeled as a continuous time diffusion process. The drift of the diffusion process is driven by the hidden credit quality. At discrete fixed times, the lender gets ego-network signals from the borrower and the borrower’s direct friends. The observation filtration thus contains continuous time borrower data augmented with discrete time ego-network signals. Combining the continuous time observation data and ego-network information, we derive filter equations for the hidden process and the properties of the conditional variance. Further, we study the asymptotic properties of the conditional variance when the frequency of arrival of ego-network signals is increased.

Kuete V, Omosa LK, Midiwo JO, Karaosmanoğlu O, Sivas H. "Cytotoxicity of 11 naturally occurring phenolics and terpenoids from Kenyan flora towards human carcinoma cells." Journal of Ayurveda and integrative medicine. 2019;10(3):178-184. AbstractJournal article

Description
Background
Cancer constitutes a major hurdle worldwide and its treatment mainly relies on chemotherapy.
Objectives
The present study was designed to evaluate the cytotoxicity of eleven naturally occurring compounds including six phenolics amongst them were 4 chalcones and 2 flavanones as well as 5 terpenoids (3 clerodane and 2 trachylobane diterpenoids) against 6 human carcinoma cell lines and normal CRL2120 fibroblasts.
Materials and methods
The neutral red uptake (NR) assay was used to evaluate the cytotoxicity of the compounds, whilst caspase-Glo assay was used to detect caspase activation. Cell cycle and mitochondrial membrane potential (MMP) were all analyzed via flow cytometry meanwhile levels of reactive oxygen species (ROS) was measured by spectrophotometry.
Results
Chalcones: 2′,4′-dihydroxy-6′-methoxychalcone (1); 4′,6′-dihydroxy-2′,5′-dimethoxychalcone (2); 2′,4 …

Kuete V, Omosa LK, Midiwo JO, Karaosmanoğlu O, Sivas H. "Cytotoxicity of naturally occurring phenolics and terpenoids from Kenyan flora towards human carcinoma cells." Journal of Ayurveda and integrative medicine. 2019;10(3):178-184. AbstractJournal article

Description
Background
Cancer constitutes a major hurdle worldwide and its treatment mainly relies on chemotherapy.
Objectives
The present study was designed to evaluate the cytotoxicity of eleven naturally occurring compounds including six phenolics amongst them were 4 chalcones and 2 flavanones as well as 5 terpenoids (3 clerodane and 2 trachylobane diterpenoids) against 6 human carcinoma cell lines and normal CRL2120 fibroblasts.
Materials and methods
The neutral red uptake (NR) assay was used to evaluate the cytotoxicity of the compounds, whilst caspase-Glo assay was used to detect caspase activation. Cell cycle and mitochondrial membrane potential (MMP) were all analyzed via flow cytometry meanwhile levels of reactive oxygen species (ROS) was measured by spectrophotometry.
Results
Chalcones: 2′,4′-dihydroxy-6′-methoxychalcone (1); 4′,6′-dihydroxy-2′,5′-dimethoxychalcone (2); 2′,4 …
Scholar articles
Cytotoxicity of naturally occurring phenolics and terpenoids from Kenyan flora towards human carcinoma cells
V Kuete, LK Omosa, JO Midiwo, O Karaosmanoğlu… - Journal of Ayurveda and integrative medicine, 2019
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Catherine K, Fidahusein DS, Wanjiru LC, Maina WJ, Carla K, Hahn D, Serge F, Paul G, Thomas S. "Effect of Vernodalol, a Sesquiterpene Lactone, on Economically Important Agricultural Fungi." International Journal of Innovative Science and Research Technology. 2019;4(3):685-694. Abstract

The status of food insecurity in the world is devastating and fungal based diseases are a major cause that result in approximately 40-60% crop yield loss. Although synthetic chemical fungicides have been the preferred immediate method for management of fungal diseases, they have undesirable effects on human and animal health; causes environmental hazards, and are expensive. This study investigated whether the natural products from Vernonia glabra (Asteraceae) could be used as alternative biofungicide against disease causing agricultural fungi. Fractions were separated from V. glabra methanolic flower crude extract, using bioassay-guided fractionation. The single pure fraction yielded was selected for bioassay tests, and was isolated and characterized using chromatographic and spectrometric methods. In vitro bioassay test was performed against spore germination of Fusarium graminearum, F. oxysporum, F. verticillioides, Zymoseptoria tritici, Ustilago maydis, and Pyricularia oryzae. A known sesquiterpene lactone, Vernodalol was identified using high resolution mass spectrometry. In vitro bioassay results revealed that spores of Z. tritici were the most susceptible to Vernodalol, (42% spore inhibition) at 33 μg/100 μL compared to Azoxystrobin, a standard fungicide, (100% inhibition) against the fungus at 0.005 μg/100 μL. Vernodalol sprayed on 7 days old wheat seedlings that were inoculated with spores of Zymosepteria tritici, Puccinia triticina, and Helminthosporium sativum, at 50 and 200 ppm did not exhibit any disease control under greenhouse conditions. Azoxystrobin exhibited 90-100% disease control. V. glabra extracts have sesquiterpene lactones which are antifungal, however Vernodalol needs further research on its structural modification to increase efficacy against fungal pathogens.
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Effective effluent treatment is a paramount step towards conserving the dwindling clean water resources. The present study describes the use of crude protease extract from Bacillus Cereus Strain KM201428 biotransformation of azo dye Reactive Black 5 (RB5). Batch experimental results displayed over 97% decolorization efficiency with initial dye concentration of 1.0 x 10-4M. The decolorization process was highly dependent on contact time, dye concentration and pH. The optimum contact time and pH for decolorization were 120 hours and pH 9 respectively at 25˚C. Biotransformation of RB5 dye was monitored using UV-Vis spectrophotometer and formed metabolites characterized by LC–QTOF-MS. Comparison of resultant LC–QTOF-MS chromatograms after decolorization confirmed complete cleavage of RB5 dye. First order kinetic fitted well with experimental data for different RB5 dye concentrations

Wanyonyi WC, Onyari JM, Shiundu PM, Mulaa FJ. "Effective biotransformation of Reactive Black 5 Dye Using Crude Protease from Bacillus Cereus Strain KM201428." Energy Procedia. 2019;157:815-824. AbstractEnergy Procedia

Description

Effective effluent treatment is a paramount step towards conserving the dwindling clean water resources. The present study describes the use of crude protease extract from Bacillus Cereus Strain KM201428 biotransformation of azo dye Reactive Black 5 (RB5). Batch experimental results displayed over 97% decolorization efficiency with initial dye concentration of 1.0 x 10-4M. The decolorization process was highly dependent on contact time, dye concentration and pH. The optimum contact time and pH for decolorization were 120 hours and pH 9 respectively at 25˚C. Biotransformation of RB5 dye was monitored using UV-Vis spectrophotometer and formed metabolites characterized by LC–QTOF-MS. Comparison of resultant LC–QTOF-MS chromatograms after decolorization confirmed complete cleavage of RB5 dye. First order kinetic fitted well with experimental data for different RB5 dye concentrations …

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Description
A systematic study of the photophysical and electrochemical properties of triscyclometalated homoleptic iridium(III) complexes based on 2-(1-naphthyl)pyridine (npy) ligands is presented. A systematic investigation of ligand substitution patterns showed an influence on the lifetime of the excited state, with slight changes in the absorption and emission spectral features. Specifically, the emission lifetime of a complex of an npy ligand substituted with a strongly electron-withdrawing trifluoromethyl group was longer than that of the corresponding complex with the electronically nonperturbed ligand (3.7 μs versus 1.5 μs). Electronically complementary ligands and complexes with orthogonal configurations showed slightly shorter excited state lifetimes compared with unsubstituted npy (1.4–3.0 μs). All complexes displayed reversible or quasireversible redox-couple processes, with the complex of the trifluoromethylated …

Njogu REN, Fodran P, Tia Y, Njenga LW, Kariuki DK, Yusuf AO, Scheblykin I, Wendt OF, Wallentin C-J. "Electronically Divergent Triscyclometalated Iridium (III) 2-(1-naphthyl) pyridine Complexes and Their Application in Three-Component Methoxytrifluoromethylation of Styrene." Synlett. 2019;30(07):792-798. AbstractSynlett

Description
A systematic study of the photophysical and electrochemical properties of triscyclometalated homoleptic iridium(III) complexes based on 2-(1-naphthyl)pyridine (npy) ligands is presented. A systematic investigation of ligand substitution patterns showed an influence on the lifetime of the excited state, with slight changes in the absorption and emission spectral features. Specifically, the emission lifetime of a complex of an npy ligand substituted with a strongly electron-withdrawing trifluoromethyl group was longer than that of the corresponding complex with the electronically nonperturbed ligand (3.7 μs versus 1.5 μs). Electronically complementary ligands and complexes with orthogonal configurations showed slightly shorter excited state lifetimes compared with unsubstituted npy (1.4–3.0 μs). All complexes displayed reversible or quasireversible redox-couple processes, with the complex of the trifluoromethylated …

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Abstract
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