Publications

Found 2874 results

Sort by: [ Author  (Desc)] Title Type Year
Filters: First Letter Of Last Name is A  [Clear All Filters]
[A] B C D E F G H I J K L M N O P Q R S T U V W X Y Z   [Show ALL]
A
A DRODHIAMBOWALTER. "Odhiambo WA, Guthua SW, Chindia ML, Macigo FG.Pattern and clinical characteristics of firearm injuries.East Afr Med J. 2008 Mar;85(3):107-12.". In: East Afr Med J. 2008 Mar;85(3):107-12. Safety 2010; 2008. Abstract

OBJECTIVE: To determine the pattern and characteristics of patients admitted with firearm injuries (FAIs) and establish the morbidity and mortality associated with these injuries. DESIGN: Retrospective cross-sectional study. SETTING: Kenyatta National Hospital (KNH), January 2004 to December 2005. SUBJECTS: All patients admitted with physically evident firearm injury. RESULTS: There were a total of 717 patients recorded with FAIs constituting 0.6% of the total number of patients seen in the casualty. Of these, 421 (58.7%) were admitted and treated as in- patients. A firearm was used in 6.7% of the 6300 assault cases recorded in 2004 and in 9.7% of the 3079 cases recorded in 2005. The increase from 6.7% in 2004 to 9.7% in 2005 was statistically significant (p < 0.05). There were 370 (87.9%) males and 49 (11.6%) females giving a male to female ratio of 7.5:1. The mean age was 29.7 +/- 10.9 years with a range of 3 to 66 years. At least 262 (62.2%) of the 421 admitted FAI casualties were treated under general anaesthesia (GA). The average duration of operation per patient was 2 +/- 1.5 hours. CONCLUSION: FAIs are on the increase and affect all age groups but is largely a disease of a young male adult in the 3rd and 4th decade of life. Mortality is higher with increasing age while female victims are fewer but on average six years younger than males. The lower extremities are the commonest target among the survivors. However, abdominal wounds tend to be the most lethal, accounting for greater mortality.

A MRMUTULIDANIEL, A MRMUTULIDANIEL. "Mutuli, D.A. (1994) The Role of Agricultural Engineering in Food Manufacturing . In Proceedings for the Kenya Institute of Food Science and Technology Conference, Nairobi, Kenya, November 7th.". In: World Employment Programme Research Working Papers, No. 45. Geneva: International Labour Office. Cambridge: Cambridge University Press.; 1994. Abstract

A description is given of a novel liquid phase immunoassay for the measurement of testosterone in peripheral venous plasma from men and women. The procedure involves: (i) competitive binding of the analyte and tritiated antigen to specific antibodies; (ii) enzymatic conjugation of the free ligand with glucuronic acid; and (iii) separation of the antibody-bound and free ligand by partition of the reactants into an organic and aqueous phase. The technique has been called ligand differentiation immunoassay (LIDIA). The mean sensitivity was 5 pg/tube (equivalent to 0.35 nmol/l female plasma; 0.87 nmol/l male plasma). The mean reagent blank (+/- SD) was 0.24 (0.12) nmol/l female plasma; 0.61 (0.30) nmol/l male plasma. A precision profile gave values less than 50%; the within batch variation was less than 8.3% and the between batch variation over three months was 12.3%. An accuracy profile between the second and penultimate points on the calibration curve gave values between 77 and 103%. The correlation coefficient 'r' between LIDIA and a heterogeneous radioimmunoassay was 0.92 when applied to plasma from men and 0.95 to samples from women.

A PROFODHIAMBOJACK. "On Cognition : Ascent from sense knowledge to knowledge of essence with publisher for evaluation.". In: J Obst Gynecol East Cent. Afric. DR. MARK NELSON AWORI; PROF. PANKAJ G. JANI; 1993. Abstract
Twenty variceal banding sessions were performed in eight patients between February 1995 and September 1996. A total of 69 rings were used to band the varices and at each session between two to six rings were used. Two of the eight had active bleeding and both underwent variceal banding to successfully arrest their bleeding as inpatients. Sixteen other variceal banding sessions were performed on an outpatient basis to obliterate their varices. Four of the eight patients had had sclerotherapy before and varices were still present. No acute or long term complications were noted. In one patient, variceal banding could not be performed as he developed stridor upon placement of the overtube. All the patients had advanced varices (Grade III or IV) and extended for more than 15 cms in the oesophagus. Endoscopic variceal obliteration remains the treatment of choice for patients with portal hypertension with variceal bleeding. Variceal banding is associated with a superior outcome when compared with sclerotherapy; the variceal kill time is shorter, infective complications less, rebleeding occurs less commonly and transfusion requirements are lower.
A PROFOMWANDHOCHARLESO. "Role of TGF-beta in normal human endometrium and endometiosis Human Reproduction 2010; 25(1):101-109.". In: journal.; 2010. Abstract

A mini review of contamination routes and limitations to effective control. Japanesegricultural Quarterly Journal 2010; 44 (1) 7-16.

A KJM, CM M, JD M, J W. "A Retrospective Study of Canine Ehrlichiosis in Kenya." International Journal of Veterinary Science. 2014;3(3):122-124.
A PROFOMWANDHOCHARLESO. "Susanne E. M. Gruessner, Charles O. A. Omwandho, Thoma Dreyer, Renate Blutters-Sawatzki, Alfred Reiter, Hans R. Tinnerberg, Rainer M. Bohle. Management of stage I cervical sarcoma botryoides in childhood and adolescence.". In: European Journal of Pediatrics 163: 452 .; 2004. Abstract

Rhabdomyosarcomas are the most common soft tissue sarcomas in childhood. The botryoid variant arises in infancy from the vagina or urinary bladder and extremely rarely from the uterine cervix. Treatment regimes range from local excision of the tumour to radical hysterectomy with adjuvant multidrug therapy and/or radiotherapy. In cases of minimal cervical invasion, the less invasive local excision in combination with adjuvant chemotherapy has resulted in excellent survival rates with complete functional preservation of the bladder, rectum, vagina, and ovaries. We present here a 30-year literature review and a case report of a cervical sarcoma botryoides in a 5-year-old girl. CONCLUSION: based on the literature review and our own observation, we recommend minor surgical approaches in combination with chemotherapy as the treatment of choice for early stage I cervical rhabdomyosarcoma. Copyright 2004 Springer-Verlag

A O. "Quality audit on Diagnosis of Pre eclampsia at Moi Teaching and Referral Hospital." Kenya Nursing Journal. 2011;41(2):45-49. Abstract

Background: Pregnancy and childbirth are usually a time of celebration in most parts of the world and is often marked with rituals in all societies. However this period of time can be the hardest of all experiences with anxiety and concern for some women. This is because a number of pregnant women end up with disabilities or even death due to pregnancy related complications. Pre eclampsia is one of the conditions that are responsible for maternal morbidity and mortality. Screening and monitoring in pregnancy are some of the strategies used by health care providers to identify high risk pregnancies so that they can provide more targeted and appropriate treatment and follow up care, and to monitor fetal well being in both low and high risk pregnancies.
Purpose: The aim of the study was to identify whether blood pressure and urinalysis are done for mothers seeking antenatal and delivery services at Moi Teaching and Referral Hospital Eldoret.
Methods: A review of records at the antenatal, labor and delivery units at Moi Teaching and Referral Hospital.
Findings: over 96% of women came for first visit and had their Blood Pressure taken, 48.7% of women came for the second visit and had their blood pressure taken, 17.8% of women came for the third visit and had their blood pressure taken and 5.6% of women came for the fourth visit and had their blood pressure taken . All women admitted to the labor ward had blood pressure measured and recorded. 40% of the women admitted to labor ward had urinalysis done.
Conclusion: Blood Pressure and urinalysis are key in the early diagnosis and management of Pre eclampsia and other hypertensive states in pregnancy. There is need that they are done as routine procedures.

A MRNYANDEGAISAIAH. "Ayiemba, E.H.O., Nyandega, I.A. and Weere, W.B., 1998: Climate Impact on Human Settlement: Case study of Laikipia and Nairobi Districts.". In: EAST AFRICAN MEDICAL JOURNAL. Association of Africa Universities; 1998. Abstract
Vertex epidural haematomas (VEDH) are rare and difficulties are encountered in diagnosis and management. This is a case report of a patient with a vertex epidural haematoma who presented with signs of severe head injury with upper limb decerebrate posture. We discuss the challenges of radiological investigation and neurosurgical management of VEDH.
A PROFOMWANDHOCHARLESO. "Omwandho CA, Tinneberg HR, Tumbo-Oeri AG, Roberts TK, Falconer J. Recurrent pregnancy losses and the role of immunotherapy. Arch Gynecol Obstet. 2000 Jul;264(1):3-12.". In: Arch Gynecol Obstet. 2000 Jul;264(1):3-12.; 2000. Abstract

Post implantation pregnancy losses are psychologically and economically stressful to the childbearing population. The etiology in the vast majority of cases is unknown but is partly thought to result from a break-down of the maternal tolerance to the fetoplacental unit. Immunologically based therapy remains controversial but no alternative therapy is available at the moment. This article reviews the conceived immunological basis of recurrent pregnancy losses, discussing the controversies arising, and recommending the use of intravenous immunoglobulin, IVIg, in well controlled experiments for further clinical trials.

A MRMAKACHIAPETER. "Appropriate Building Materials & Construction Technology For Primary Schools In Kerio Valley.". In: International Course Of Organized Self-Help Housing Planning & Development. HRDU, University of Nairobi; 1985. Abstract
Heavily glazed office buildings in the Kenyan Capital City Nairobi, common in recent times does not augur well for a micro and macro architectural environment. This has a consequent negative impact on energy use in office spaces. By use of computer simulations, traditional tools and literature review glazing use in office fenestration is analysed and its implications for architectural design investigated. The results indicate a direct relationship between the variable parameters of glazing type and size, glazed opening orientation, shading devices and control of energy loads within the office spaces and the objective of human comfort in the office spaces. In conclusion it is recommended that optimum levels of glazing size and type as well as suitable glazing orientations for architectural use in office buildings in Nairobi.
A PROFOMWANDHOCHARLESO. "NATURAL KILLER CELLS AND SELECTED ENZYME/ METABOLITE PROFILES IN HIV INFECTION AND PROGRESSION TO AIDS (Mecha, Ezekiel Onyonka. (MSc. Hons), UON.". In: M.Sc. Thesis.; 1989. Abstract

Abstract   Acquired immune Deficiency syndrome (AIDS) is a disease of grave psychological and economic concern. It effects all sectors of the community namely education, military, health, transport and communication. To date, it is estimated that 40 million people are infected with the virus globally of which 28.5 million resides in Sub Saharan Africa   This study sought to evaluate the role of Natural killer cells in Human Immunodeficiency Virus infection. It

A DRINDALOANNE. "Kokwaro GO, Indalo AA.Metabolism of Diazepam and Ethosuximide in rats with malaria and endotoxin-induced fever. Afr J Health Sci. 1996 Feb;3(1):22-6.". In: 1: Eur J Drug Metab Pharmacokinet. 1996 Jan-Mar;21(1):13-6. The Indian Journal of Animal Sciences; 1996. Abstract
We have investigated the effects of malaria infection with rodent parasite Plasmodium berghei and fever induced by Escherischia coli endotoxin on the metabolism of diazepam to temazepam by rat liver microsomes, and on the clearance of ethosuximide in vivo in the rat. Livers from malaria-infected (parasitaemia =36.8+/- 7.6% endotoxin-treated or saline-treated (control) rats (N=5 per treatment) were used to prepare microsomes. These were incubated with diazepam (10-600ū M) for 10 minutes in an NADPH-generating system. V( max), K(m ) and the intrinsic clearance V(max )/K(m ) for the production of temazepam were determined. In separate experiments, ethosuximide (5mg/kg) was administered via the tail vein to control, malaria-infected and endotoxin-treated rats (parasitaemia=43.8+/- 5 %) under light ether anesthesia (N=5 per treatment). Total clearance of ethosuximmide was estimated form a single blood sample obtained 24h after drug administration. Diazepam metabolism was not affected by malaria infection or fever (V(max ):1.31+/- 0.34,0.73+/- 0.27 and 1.07+/- 0.78 nmol/min/mg protein; K( m): 158.7 +/- 63.7, 175.3+/- 44.9 and 190.0+/- 81.8ūM; Intrinsic clearance/whole liver: 0.31+/- 0.16, 0.26+/- 0.1 and 0.29+/- 0.1ml/min in livers from control, malaria-infected and endotoxin-treated rats respectively; P>0.05). Similarly, clearance of ethosuximide in vivo was not affected by malaria infection or fever (1.3+/- 0.2, 1.3+/- 0.01 and 1.4+/- 0.4 ml/min/kg in control, malaria-infected and endotoxin-treated rats respectively; p>0.05). These results suggest that malaria infection and fever have no effect on the activities of the CYP3A isozymes thought to be involved in the metabolism of diazepam and ethosuximide.
A DROBONDOANNE, M PROFNDETEIDAVID. "Obondo A.A, Khasakhala L, Ndetei D.M, Mutiso V, Ongecha .". In: In Eds. Ndetei et al (2006). International Psychiatry Vol.6 No. 1; 2006.
A D, D O, E O. "Development of the roadmap and guidelines for the prevention and management of high blood pressure in Africa: Proceedings of the PASCAR Hypertension Task Force meeting.". In: : Proceedings of the PASCAR Hypertension Task Force meeting.; 2014. Abstract

Africa has one of the fastest growing economies in the world. The economic changes are associated with a health transition characterised by a rise in cardiovascular risk factors and complications, which tend to affect the African population at their age of maximum productivity. Recent data from Africa have highlighted the increasing importance of high blood pressure in this region of the world. This condition is largely underdiagnosed and poorly treated, and therefore leads to stroke, renal and heart failure, and death. Henceforth, African countries are taking steps to develop relevant policies and programmes to address the issue of blood pressure and other cardiovascular risk factors in response to a call by the World Health Organisation (WHO) to reduce premature deaths from non-communicable diseases (NCDs) by 25% by the year 2025 (25 × 25). The World Heart Federation (WHF) has developed a roadmap for global implementation of the prevention and management of raised blood pressure using a health system approach to help realise the 25 × 25 goal set by the WHO. As the leading continental organisation of cardiovascular professionals, the Pan-African Society of Cardiology (PASCAR) aims to contextualise the roadmap framework of the WHF to the African continent through the PASCAR Taskforce on Hypertension. The Taskforce held a workshop in Kenya on 27 October 2014 to discuss a process by which effective prevention and control of hypertension in Africa may be achieved. It was agreed that a set of clinical guidelines for the management of hypertension are needed in Africa. The ultimate goal of this work is to develop a roadmap for implementation of the prevention and management of hypertension in Africa under the auspices of the WHF.

A MRKABURIAHF. "Efficacy of Myrisine africana, Albezia anthelmintica and Hilderbrantia sepalosa herbal remedies against mixed natural sheep helminthosis in Samburu District, Kenya.". In: Proceedings of The First National Workshop on medicinal, aromatic and other under utilized plant species in Kenya held on 29th October to 3rd November 2001 at Kenya Wildlife Service Training Institute, Naivasha, Kenya. GIGA German Institute of Global and Area Studies, Hamburg, July 2009; 2001. Abstract
This integrative review on the teaching of reading in Kenyan primary schools provides a foundation for the growing movement there to improve reading education. In gathering sources for this review, we took an inclusive historical stance. Thus, we did not dismiss research reports that lacked traditional indicators of quality such as being published in peer-reviewed journals. We used multiple methods to find relevant research and associated documents, including two trips to Kenya. The review is organized by six topics: (a) language of instruction, (b) reading instruction, (c) reading materials, (d) reading culture, (e) assessment, and (f) teacher development. The review concludes with six proposals for policymakers, educational researchers, and teacher educators for the development of reading instruction based on what we learned in reviewing the literature. The first proposals are intended specifically to address the teaching of reading in Kenya, but they may be relevant to other sub-Saharan nations. The final proposal encourages others to conduct similar reviews to make possible a handbook of reading in Africa.
A WG, D. A, O. AA, GN K, I.N M, J.K M. "Kinetics and Isothermal Studies of Lambda Cyhalothrin Sorption on eburru Soils in Kenya." Journal of Kenya Chemical Society. 2017;10(1):24-34.
A DRRAJABJAMILLA. "Rajab JA, Muchina WP, Orinda DA, Scott CS. Blood donor haematology parameters in two regions of Kenya.East Afr Med J. 2005 Mar;82(3):123-7.". In: East Afr Med J. 2005 Mar;82(3):123-7. VDM Verlag; 2005. Abstract
Department of Haematology and Blood Transfusion, College of Health Sciences, University of Nairobi, P. O. Box 19676, Nairobi, Kenya. OBJECTIVES: To determine the status of blood donor haematology in two regional sites in Kenya and to assess the potential role of automated haematology in National blood bank process control. DESIGN: A cross sectional descriptive study. SETTING: Two regional blood banks–Nairobi and its environs (Blood Transfusion Services, Nairobi) and Western Region (National Blood Transfusion Services, Kisumu). MAIN OUTCOME MEASURES: Distribution, mean, median, and 95% percentile ranges of haemoglobin (Hb), red cell parameters (red cell count, haematocrit, MCV, MCH and MCHC), total and differential white blood cell (WBC) counts, and platelet counts in the two donor populations. RESULTS: A significant number of donations (16.5% in Kisumu and 3.4% in Nairobi) showed haemoglobin levels below the recommended National Blood Transfusion Service (NBTS) guideline of 42g/unit. Compared to Kisumu, Nairobi donors had significantly (p < 0.001) higher Hb, MCV and MCH values while the red blood cell counts and MCHC values were similar (p > 0.05). A low MCV (< 78 fl) was observed in 12.4% and 3.4% of Kisumu and Nairobi donors respectively. Both populations showed similar but significant frequencies (Kisumu, 21.3%; Nairobi, 18.7%) of mild neutropenia (< 1.5 x 10(9)/1), while eosinophilia (> 0.5 x 10(9)/1 in the tropics the cut off is > 0.6 x 109) was more prominent in Kisumu donors (18.8% versus 8.5%). Platelet counts were also significantly lower in Kisumu donors, with the prevalence of thrombocytopenia (< 150 x 10(9)/1) being considerably higher (15.9% versus 3.7%). CONCLUSIONS: A significant number of Kenyan donors showed abnormal haematology profiles that may indicate underlying pathology. Such abnormalities are not detected by current blood transfusion services screening practices and there may be a need to strengthen donor selection criteria to protect both donors and recipients.
A PROFOMWANDHOCHARLESO. "Konrad L.1, Owmandho C.A.2 , von Hobe A.-K. 1, Sui C. 1, Kloeppels K1.,Hersemeyer K.1 Tinneberg H.-R 1 In proceedings of 14th World Congress of Gynecological Endocriology, ISGE. March 4-7, 2010, Firenza, Italy. 1 University of Giessen, Department of Gynec.". In: In proceedings of 14th World Congress of Gynecological Endocriology, ISGE. March 4-7, 2010, Firenza, Italy.; 2010. Abstract

Introduction: To establish  a model for investigationg endometrics in vitro, we analyzed several immortalized endometrial and endometriotic cell lines for typical biological functions. Especially transforming growth factor (TGF)-betas were investigated, because TGF-betas are increased during menstrual and endometriosis and seem to modulate effects of progesterone on endometrial cells primarily on secretion of matrix metalloproteinases (MMPs).Methods: We used two stroma and one epithelial cell line from human endometrium and one stromal and three epithelial cell lines from endometrial patients. Protein secretion was quantitated with ELISAs and apoptosis determined with FACS analysis.Results: All cell lines secrete TGF-beta1, but interestingly the endometriotic cell lines secret considerably higher levels compared to normal endometrial cells. Of note,not the endometriotic cells secrete TGF-beta2. However, all cell lines only produce very slow levels of TGF-beta3. All cell lines could be stimulated by TGF-bata because they express high-affinity receptors TBR1 and TBR2. Treatment with TGF-betas reduced cell proliferation by innducing apoptosis, whereas TGF-beta1 more efficiently increased secretion of MMP2 compared to TGF0beta2. Progesterone reduced cell proliferation dose-dependent but induced secretion of TGF-beta1 and TGF-beta2. Interestingly TGF-beta3 was predominantly found in endothelial cells of patients with endometriosis.Conclusion: The results obtained with the endometrial and endometriotic celss lines are highly consistent with published data. For example TGF-beta1 is the predominant TGF-beta isoform in explant cultures as well as in endometriosis, followed by TGF-beta2 and very low levels of TGF-beta3. Our results convincingly demonstrate that cell lines are a suitable model for studying endometriosis.

A BO, Ogara WO, Ouma GO, Onono JO. "Comparative analysis of rainfall trends in different Sub-Counties in Kajiado County Kenya." International Journal of Innovative Research Studies. 2015;13(2).
A PROFOMWANDHOCHARLESO. "S. Gruessner, C. A. Omwandho, V. Klingmueller, R. M., Bohle, H.-R Tinneberg. Cerebro and cardiovascular responses and oxygen consumption during prolonged hypoxia in fetal sheep. In Proceedings of the 15th World Congress on Ultrasound in Obstetrics and Gyn.". In: Ultrasound in Obstetrics and Gynecology 26: 449.; 2005. Abstract

OBJECTIVE: To study re-association pattern of human placental eluate immunoglobulins with acid treated isologous and third party trophoblast derived placental microvesicles. DESIGN: Laboratory based experimentation. SETTING: Biological Sciences Department and Discipline for Reproductive Medicine University of Newcastle, Australia and the Department of Biochemistry, University of Nairobi, Kenya. RESULTS: Placental eluate immunoglobulins re-associated with isologous and third party acidified microvesicles in three distinct patterns. I: eluate immunoglobulins re-associated more strongly with isologous and third party acid treated placental microvesicles, II: eluate immunoglobulins re-associated strongly with isologous but weakly with third party acid treated placental microvesicles, III: eluate immunoglobulins did not show preferential re-association with isologous and third party acid treated placental microvesicles. CONCLUSION: Two types of antigenic epitopes I and II may be expressed on the human placentae. Type I antigens may be present on all human placentae while type II epitopes may be paternally derived hence unique to each pregnancy. Also, immunoglobulins produced to placental microvesicle antigens may be directed to some but not all antigenic epitopes expressed on the human placental trophoblast.

A DROBONDOANNE, M PROFNDETEIDAVID, M. DRKATHUKUDAMMAS, JOSEPH DROTHIENOCALEB. "Othieno C. J., Obondo A. A., Kathuku D. M., and Ndetei D. M. (2001). Patterns of substance use among Kenya street Children.Southern African Journal of Child and Adolescent Mental Health Vol. 12, no. 2: 154-150.". In: Southern African Journal of Child and Adolescent Mental Health Vol. 12, no. 2: 154-150. Equinet; 2001. Abstract
OBJECTIVE: To determine the prevalence of tardive dyskinesia among psychiatric in-patients. DESIGN: A cross-sectional survey. SETTING: Mathari Hospital, Nairobi, the main psychiatric referral hospital in Kenya. SUBJECTS: Two hundred and two randomly selected in-patients seen in the hospital between January and April 2000. RESULTS: The prevalence of tardive dyskinesia was 11.9%. Neither the psychiatric diagnosis nor the sex was significantly associated with tardive dyskinesia. The antipsychotic dosage was also not associated with tardive dyskinesia but an increase in age was significantly associated with the abnormal movements. CONCLUSION: The prevalence rate of tardive dyskinesia among patients at Mathari Hospital is much lower than that found in western countries but similar to that from Asian studies. These findings indicate the possibility of racial differences in the aetiology of TD. Prospective cross-racial studies are necessary to confirm these findings.
A PROFOMWANDHOCHARLESO. "Omwandho, CA., Tinneberg H.R., Tumbo Oeri AG., Roberts TK., Falconer J (2001): Immunological role of placenta, Blocking factors and NK Cells in the post implantation pregnancy.". In: African Journal of Health Sciences 8: 2 .; 2001. Abstract

BACKGROUND: In normal pregnancy, the pregnant mother paradoxically tolerates the semi-allogeneic foetus until term. Experimental and clinical data to explain such tolerance in man reflects the involvement of multiple mechanisms. OBJECTIVE: To review the data pertaining to the experimental and clinical efforts to explain why the mother immunologically tolerates a semi-allogeneic pregnancy to term. DESIGN, SETTING AND METHODS: A review of the literature on state of the art thinking among researchers and clinicians on recurrent spontaneous abortions is summarised. RESULTS: A large body of recently published data strongly suggest that a breakdown in immunological maternal-foetal interactions may lead to occasional or recurrent foetal loss. Immunoregulatory activities involving blocking antibodies, regulatory factors, immunological cells, hormones, structural proteins and cytokines constitute the pregnancy-sustaining network. CONCLUSION: The majority of the evidence reviewed points to the involvement of immunological factors in successful pregnancies. However, the underlying mechanisms are inadequately explained, are largely speculative and require more focused investigation. A complete understanding of the mechanisms involved would enhance our capacity to develop rational ways of addressing recurrent pregnancy losses.

A MRMAKACHIAPETER. "Influence Of House Form On Dweller-Initiated Transformations In Urban Housing.". In: XXXIII IAHS World Congress On Housing At The University Of Pretoria, South Africa. University Of Pretoria, South Africa; 2005. Abstract
Heavily glazed office buildings in the Kenyan Capital City Nairobi, common in recent times does not augur well for a micro and macro architectural environment. This has a consequent negative impact on energy use in office spaces. By use of computer simulations, traditional tools and literature review glazing use in office fenestration is analysed and its implications for architectural design investigated. The results indicate a direct relationship between the variable parameters of glazing type and size, glazed opening orientation, shading devices and control of energy loads within the office spaces and the objective of human comfort in the office spaces. In conclusion it is recommended that optimum levels of glazing size and type as well as suitable glazing orientations for architectural use in office buildings in Nairobi.
A PROFOMWANDHOCHARLESO. "Oloowokere, JO., Makawiti, DW., Konji. VN., Omwandho, CA. Experimental Kwashiokor and Obesity: Differences in Energy Metabolism and relative Organ body weight Ratios.". In: International Journal of Biochemie Physics 1: 26 .; 1991. Abstract

Resting metabolic rates have been measured and compared with hepatic mitochondrial respiration in Kwashiorkor and diet-induced obese weaned rats. In Kwashiorkor, resting metabolic rate was 21% lower than the value of controls, while that of the obese rats was 14% higher than in control animals. The resting metabolic rate for Kwashiorkor animals was 50% of the predicted basal metabolic rate (BMR), whereas that of the obese rats was 23% higher than the predicted BMR. The mitochondrial oxygen consumption patterns, using malate plus glutamate or succinate as respiratory substrates, revealed that the resting respiration (state 4) was 23.9% higher in Kwashiorkor and 29.1% higher in obese animals, while the active (state 3) respiration was 34.8% lower in Kwashiorkor and 43.3% lower in obese rats compared to controls. The respiratory control ratios (RCR) were 51.1% and 43.8% in Kwashiorkor and obese rats, respectively, relative to the values in control rats. It is concluded from these studies that Kwashiorkor disease and diet-induced obesity appear to interfere with oxygen utilization at the level of state 3 mitochondrial respiration, which is markedly decreased when compared to the values for control animals.

A DRINDALOANNE. "Pharmacokinetics of oxamniquine in rabbit and rat.Eur J Drug Metab Pharmacokinet. 1996 Jan-Mar;21(1):13-6.". In: 1: Eur J Drug Metab Pharmacokinet. 1996 Jan-Mar;21(1):13-6. The Indian Journal of Animal Sciences; 1996. Abstract
The pharmacokinetics of the schistosomicidal agent oxamniquine (6-hydroxmethyl-2-isopropylaminomethyl-7-nitro-1,2,3,4-tetra hydroquinoline) were studied in 8 (4 male, 4 female) New Zealand White rabbits and 5 female Wistar rats, following intravenous administration (15 mg/kg). The pharmacokinetic parameters (mean +/- SD) in the rabbit and rat, respectively, were as follows: plasma clearance, 65.5 +/- 33 and 17.2 +/- 5.7 ml/min/kg; steady-state volume of distribution, 7.9 +/- 4.5 and 2.1 +/- 0.5 l/kg; terminal elimination half-life, 1.8 +/- 0.3 and 1.8 +/- 0.9 h. Oxamniquine appeared to be widely distributed in both species, although significantly higher in the rabbit. Similarly, plasma clearance was significantly higher in the rabbit. Using reported estimates of liver blood flow and fractions excreted unchanged in urine of the rabbit and rat, calculations based on blood clearances indicated that oxamniquine has a low hepatic extraction ratio (0.2) in the rat and an intermediate hepatic extraction ratio (0.6) in the rabbit. From separate experiments, however, hepatic extraction appeared to be low in the rabbit, suggesting that oxamniquine disposition is probably broadly similar in both rabbit and rat.
A DROWILLAHFRANCIS. "Pattern and outcome of abdominal injuries at Kenyatta National Hospital, Nairobi.". In: East Afr Med J. 2006 Jan;83(1):37-43. 1999; 2006. Abstract
OBJECTIVE: To establish the pattern and results of interventions in patients with abdominal injuries requiring admission. DESIGN: A descriptive, prospective, hospital-based study involving observation of patients from admission to final outcome of management as either discharged or deceased. SETTING: Kenyatta National Hospital, a tertiary teaching and referral hospital in Nairobi, Kenya, from November 2004 to February 2005 in the adult general surgical wards. PATIENTS: Eighty consecutive admissions of adult patients with either blunt or penetrating abdominal injuries. MAIN OUTCOME MEASURES: Type and cause of injury, demographic data, temporal parameters, morbidity and mortality. RESULTS: The 80 patients had a male to female ratio of 12.3:1, the majority were in the third decade of life with a range 15-56 years and mean of 28.2 years. Penetrating to blunt abdominal injuries had 2:1 ratio with the leading causes of injury being stab wounds, gunshot wounds and road traffic accidents. Blunt abdominal injuries had a higher tendency to extra-abdominal injuries. Duration prior to presentation to hospital and surgery depended on severity of injury. Modes of management varied between attending surgical firms. There was a 20% change in the mode of management and a 16.1% rate of negative laparotomy. Penetrating injuries had a better interventional outcome. Penetrating abdominal injuries had higher rates of complications while the blunt injuries had higher rates of mortality. Overall, both the complication and mortality rates were 12.5%. Correlates of mortality included delay before surgery, associated injuries, need for blood transfusion, admission to intensive care unit and duration prior to admission. Abdominal injury patients stayed an average of 6.4 days with the blunt injuries with complications staying close to twice as much as their penetrating counterparts. CONCLUSION: Abdominal injuries are a predominantly male disease with the majority in the third decade of life. As opposed to previous studies, gunshot wounds are now a significant cause of abdominal injuries in Kenyatta National Hospital (KNH). The rate-of negative laparotomies has come down by 10% over the past 15 years. The outcome of management depends on the severity and type, of injury sustained.
A DROBONDOANNE, M PROFNDETEIDAVID, M. DRKATHUKUDAMMAS, JOSEPH DROTHIENOCALEB. "Othieno C. J., Obondo A. A., Kathuku D. M., and Ndetei D. M. (2001). Patterns of substance use among Kenya street Children.Southern African Journal of Child and Adolescent Mental Health Vol. 12, no. 2: 154-150.". In: Southern African Journal of Child and Adolescent Mental Health Vol. 12, no. 2: 154-150. International Psychiatry Vol.6 No. 1; 2001. Abstract

BACKGROUND: The quality of life of cancer patients is likely to be influenced by psychological reactions of the cancer patients yet there are no documented issues related to quality of life in cancer patients in Kenyan hospitals. OBJECTIVE: To investigate issues which affect the quality of life in male cancer patients. DESIGN: Prospective cross sectional study. SETTING: Kenyatta National Hospital, Nairobi, Kenya. METHODS AND SUBJECTS: Cancer patients above 12 years of age were interviewed during the course of their stay in the hospital, specifically to gather information on; semi structured questions and a modified Beck's 24 item depression inventory with a view to solicit for their reaction on issues which pertains to quality of life. MAIN OUTCOME MEASURES: Age group, level of education, tribe, geographical place (province) of birth, chief complains, main concerns, views on doctors, contact with psychiatrist and psychologist, the anatomic site of cancer, treatment given and responses on modified Beck's depression inventory. RESULTS: Forty two patients were studied, their age range 13-72 years, mean 43.2 and peak 13-26 years. Forty seven per cent of cases had no formal education. The cancers were gastrointestinal tract 33%, blood and lymphoid tissue (26%), bone and muscle (11.9%), skin (9.4%) and genitourinary tract (4.8%). Treatment given was chemotherapy, radiotherapy and surgery. Ninety three per cent were unable to cope. Chief complaints were pain, inability to work, feeling miserable and concerns were families, health and work retardation. Modified Beck's depression score was 20%, with major issues being; work retardation, insomnia, weight loss, and anorexia. Most affected were, age group 27-35 years (and least 13-26 years), uneducated, living in Nairobi (city), having carcinomas, treatment with combined surgery and radiotherapy. Low education level and residence in Nairobi coped poorly. Radiation therapy group appeared to cope better than other modalities. CONCLUSION: The issues affecting the quality of life of male cancer patients stated were pain, inability to work, poor coping with cancer and psychological reactions of work retardation, insomnia, weight loss, fatigability and depression. Gambling, suicidal ideas and social withdrawal were minimal. Other concerns were families, health and work.

A DRMASIGAMARY. "Masiga MA, Holt RD. The prevalence of dental caries and gingivitis and their relationship to social class amongst nursery-school children in Nairobi, Kenya. Int J Paediatr Dent. 1993 Sep;3(3):135-40.". In: Int J Paediatr Dent. 1993 Sep;3(3):135-40. University of Nairobi.; 1993. Abstract

Four hundred and forty-six children attending nursery schools in Nairobi were examined for caries and gingivitis. Assessment of social class was based on the occupation of the head of the child's household. Amongst 3-year-old children, 62% were caries-free and the mean dmft was 1.35. Amongst 5-year-olds 50% were caries-free and the mean dmft was 1.88. Thirty-seven per cent of the children had evidence of gingivitis, with the proportion changing little with age. There was no evidence of either caries or gingivitis being significantly related to social class, although children in the higher classes had more filled teeth.

and A TSR. "Ulimwengu wa Kanga." The University of Nairobi Journal of Language and Linguistics. 2016;5:195-203.
A DRODHIAMBOWALTER. "Maxillary obturator prosthesis rehabilitation following maxillectomy for ameloblastoma: case series of five patients. Int J Prosthodont. 2004 Jul-Aug;17(4):464-8.". In: Int J Prosthodont. 2004 Jul-Aug;17(4):464-8. Journal of Public Health Policy; 2004. Abstract
OBJECTIVE: To determine the pattern and characteristics of patients admitted with firearm injuries (FAIs) and establish the morbidity and mortality associated with these injuries. DESIGN: Retrospective cross-sectional study. SETTING: Kenyatta National Hospital (KNH), January 2004 to December 2005. SUBJECTS: All patients admitted with physically evident firearm injury. RESULTS: There were a total of 717 patients recorded with FAIs constituting 0.6% of the total number of patients seen in the casualty. Of these, 421 (58.7%) were admitted and treated as in- patients. A firearm was used in 6.7% of the 6300 assault cases recorded in 2004 and in 9.7% of the 3079 cases recorded in 2005. The increase from 6.7% in 2004 to 9.7% in 2005 was statistically significant (p < 0.05). There were 370 (87.9%) males and 49 (11.6%) females giving a male to female ratio of 7.5:1. The mean age was 29.7 +/- 10.9 years with a range of 3 to 66 years. At least 262 (62.2%) of the 421 admitted FAI casualties were treated under general anaesthesia (GA). The average duration of operation per patient was 2 +/- 1.5 hours. CONCLUSION: FAIs are on the increase and affect all age groups but is largely a disease of a young male adult in the 3rd and 4th decade of life. Mortality is higher with increasing age while female victims are fewer but on average six years younger than males. The lower extremities are the commonest target among the survivors. However, abdominal wounds tend to be the most lethal, accounting for greater mortality.
A MRMUTULIDANIEL, A MRMUTULIDANIEL. "Mutuli, D.A. (1982) The general position paper for the coffee factories section of the Ministry of Agriculture. Government Working Paper (unpublished).". In: World Employment Programme Research Working Papers, No. 45. Geneva: International Labour Office. Cambridge: Cambridge University Press.; 1982. Abstract

A description is given of a novel liquid phase immunoassay for the measurement of testosterone in peripheral venous plasma from men and women. The procedure involves: (i) competitive binding of the analyte and tritiated antigen to specific antibodies; (ii) enzymatic conjugation of the free ligand with glucuronic acid; and (iii) separation of the antibody-bound and free ligand by partition of the reactants into an organic and aqueous phase. The technique has been called ligand differentiation immunoassay (LIDIA). The mean sensitivity was 5 pg/tube (equivalent to 0.35 nmol/l female plasma; 0.87 nmol/l male plasma). The mean reagent blank (+/- SD) was 0.24 (0.12) nmol/l female plasma; 0.61 (0.30) nmol/l male plasma. A precision profile gave values less than 50%; the within batch variation was less than 8.3% and the between batch variation over three months was 12.3%. An accuracy profile between the second and penultimate points on the calibration curve gave values between 77 and 103%. The correlation coefficient 'r' between LIDIA and a heterogeneous radioimmunoassay was 0.92 when applied to plasma from men and 0.95 to samples from women.

A PROFOMWANDHOCHARLESO. "Daudi K. Langat(1), Pedro J. Morales(1), Charles O. Omwandho(2), Asgerally T. Fazleabas(3), Joan S. Hunt(1). Polymorphisms in Paan-AG promoter influences NF-kB binding and transcription activity in HEK293 cells. In Proceedings of the 39th Meeting of the S.". In: Biology of Reproduction. Special Issue, July 2006, pp 73, Abstract No. 13.; 2006. Abstract

1. University of Kansas Medical Center, Kansas, KS 2. University of Nairobi, Nairobi, Kenya 3. University of Illinois at Chicago, Chicago, IL The human leukocyte antigen-G(HLA-G), a protein highly expressed at the human maternal-fetal interface during pregnancy, is thought to be critical for the survival of the semi-allogenic fetus. Current evidence suggests that HLA-G programs immune cells at the maternal-fetal interface into immunosuppressive phenotypes, but definitive proof remains elusive since the vivo experiments in humans are not possible due to ethical concerns. In the search for an appropriate animal model, we have identified the olive baboon (Papio anubis) as a potential candidate. The primate expresses an HLA-G-like protein termed Paan-AG n the placenta. Preliminary data shows that Paan-AG gene shares many characteristics with HLA-G, including limited polymorphism, alternative splicing of the mRNA, and restricted tissue expression of the protein. Restricted tissue expression suggested that the two genes might share tissue-specific regulatory elements. We previously identified a number of two Paan-AG alleles, 5'UTAG-1(AG1) and 5'UTAG-2(AG2). The objective of the current study was to assess binding of the transcription factor NF-kB to Paan-AG promoter activity. Both alleles contained two kB elements, kB1 and kB2. Binding was assessed using electrophoretic mobility shift assays and functional activity using luciferase reporter assays. NF-kB bound both kB1 and kB2 elements in the AG1 allele. In contrast, only kB1 of the AG-2 allele bound to NF-kB; kB2 did not bind. The AG2 kB1. Mutagenesis studies showed that the difference in binding was due to two alleles also differed; AG2 consistently showed higher luciferase activity compared to AG1. Mutating the last two nucleotides in the 3' end of kB1 resulted in an increase of luciferase activity to levels comparable to that of AG2. Overall, these results suggests that variations in the proximal promoter may influence transcription rates of Paan-AG as reported recently for HLA-G, and provide further evidence of the potential usefulness of the baboon as a model for in vivo HLA-G studies. Supported by NIH grant HD39878 (JSH)

A PKARANIFLORIDA. "Capacity Building and Women Empowerment, Towards realization of Kenya Vision 2030”: .". In: the Kenya Public Service Week . Kenyatta International Conference Center (KICC) ; 2009.
A K. Survival rate of proximal ART restorations. Saarbrucken: LAP Lambert Academic Publishing GmbH & Co; 2011.
A PROFOMWANDHOCHARLESO. "Konji, VN., Makawiti, DW., Kiaira, JK., Omwandho, CA., Oloowokere, JO. Defects in respiration in mitochondria isolated from liver of goats infected with Trypanosoma Congolense.". In: International Journal of Biochemie Physics 2: 152 .; 1993. Abstract

Immunoglobulins were eluted from ovine placentae and characterized by immunoprecipitation, electrophoresis, western blotting and ELISA.IgG was shown to comprise the bulk of placental-bound immunoglobulins while smaller amounts of IgM and only trace amounts of IgA were demonstrated.Results suggest that ovine placental IgG eluted by surgical cannulation of the uterine blood vessels in situ is similar to that eluted from postpartum placentae in vitro, implying that there may be some transfer of antibodies across the maternal side of the placental barrier to the trophoblast.These antibodies are rich in IgG1 and IgG2, have a relative molecular weight of 158 kDa, and bind to an 80 kDa peptide prepared from pre-acidified ovine placental cotyledons.We propose that the binding of placental IgG to the 80 kDa antigen may prevent immunological rejection of the foetus by competitively excluding cytotoxic cells of maternal origin such as NK cells.Also, given that a similar antigen (80 kDa) has been reported in humans and equines, and shown to be saturated with IgG in term placentae, we propose that this antigen may be conserved in several mammalian species for reproductive purpose.Consequently, we suggest that the ovine placental IgG and the 80 kDa antigen may be suitable as models for the study of maternal-foetal interactions in mammalian pregnancies.

A DROBONDOANNE, M PROFNDETEIDAVID. "Ngare D, Obondo A. A, Neema S, Oladimeji B.Y, Ndetei D, M, Chikovore J. .". In: In Eds. Ndetei et al (2006). International Psychiatry Vol.6 No. 1; 2006.
A AS. Export Marketing: A Case Study of Handicraft Exporters. . Nairobi: University of Nairobi.; 1988.
A DRMASIGAMARY. "Nyamu, E.N., Masiga, M.A., Gathece, L.W., Mutara, L.N. Knowledge attitude and practices of care givers attending the Kenyatta N. Hospital MCH clinics towards oral health of their children. Afri. J. of Oral Health Sciences. 2003; 4 (3): 326 .". In: Afri. J. of Oral Health Sciences. 2003; 4 (3): 326 . University of Nairobi.; 2003. Abstract
OBJECTIVES: To evaluate the socio-demographic characteristics, chief complaints and clinical presentation of children attending a private dental clinic in Nairobi, Kenya. DESIGN: A retrospective survey of dental clinic records. SETTING: A private dental clinic in Nairobi, Kenya. SUBJECTS: All patients aged 0-18 years who were first-time attenders at the dental clinic during a three year period. RESULTS: The records of 800 patients were examined, comprising 395 males and 405 female children. The average age was 7.2 years (95%CI, 6.9-7.4). Referral to the clinic for treatment was mostly by self (81.4%). Most patients (57.9%) were self-sponsored for their dental treatment. Majority of the patients attending (86.8%) did not clinically have any underlying medical conditions. The major complaints for most patients were dental decay (27.4%) and dental pain (21.6%). Very few children (7.6%) attended for dental check-up. Five hundred and forty nine (68.6%) of the children suffered from dental decay while 294 (36.8%) suffered from gingivitis. The average number of teeth decayed was 4.02, SD +/- 2.4 (95% CI 3.8-4.2). Most carious lesions occurred in the younger children. There was a significant increase in the occurrence of decay over the three year period of the study. Significantly higher levels of gingivitis was observed in the prepubertal and pubertal age group. Attendance for traumatic injuries was relatively low with only 46 (5.8%) children reporting traumatic injuries to their dentitions. Most traumatic injuries involved the anterior teeth as a result of falls. Treatment given at the first visit was mainly restorative (28.6%) followed by dental extractions (25.4%). CONCLUSION: The average are of patients attending the clinic was 7.2 years. Interdisciplinary referral was low since most patients were self-referred and self sponsored for treatment. Dental caries was prevalent, necessitating a high demand for restorative treatment. Although gingivitis was less prevalent, it was significant among children in the prepubertal years.
A DRODHIAMBOWALTER. "Odhiambo WA, Guthua SW, Chindia ML, Macigo FG.Pattern and clinical characteristics of firearm injuries.East Afr Med J. 2008 Mar;85(3):107-12.". In: East Afr Med J. 2008 Mar;85(3):107-12. Safety 2010; 2008. Abstract
OBJECTIVE: To determine the pattern and characteristics of patients admitted with firearm injuries (FAIs) and establish the morbidity and mortality associated with these injuries. DESIGN: Retrospective cross-sectional study. SETTING: Kenyatta National Hospital (KNH), January 2004 to December 2005. SUBJECTS: All patients admitted with physically evident firearm injury. RESULTS: There were a total of 717 patients recorded with FAIs constituting 0.6% of the total number of patients seen in the casualty. Of these, 421 (58.7%) were admitted and treated as in- patients. A firearm was used in 6.7% of the 6300 assault cases recorded in 2004 and in 9.7% of the 3079 cases recorded in 2005. The increase from 6.7% in 2004 to 9.7% in 2005 was statistically significant (p < 0.05). There were 370 (87.9%) males and 49 (11.6%) females giving a male to female ratio of 7.5:1. The mean age was 29.7 +/- 10.9 years with a range of 3 to 66 years. At least 262 (62.2%) of the 421 admitted FAI casualties were treated under general anaesthesia (GA). The average duration of operation per patient was 2 +/- 1.5 hours. CONCLUSION: FAIs are on the increase and affect all age groups but is largely a disease of a young male adult in the 3rd and 4th decade of life. Mortality is higher with increasing age while female victims are fewer but on average six years younger than males. The lower extremities are the commonest target among the survivors. However, abdominal wounds tend to be the most lethal, accounting for greater mortality.
A MRMUTULIDANIEL, A MRMUTULIDANIEL. "Mutuli, D.A. et al. (1985) The joint GOK/IDA/CDC/Smallholder Coffee Improvement Project supervision and review mission report. Report of findings submitted to the project steering committee.". In: World Employment Programme Research Working Papers, No. 45. Geneva: International Labour Office. Cambridge: Cambridge University Press.; 1985. Abstract

A description is given of a novel liquid phase immunoassay for the measurement of testosterone in peripheral venous plasma from men and women. The procedure involves: (i) competitive binding of the analyte and tritiated antigen to specific antibodies; (ii) enzymatic conjugation of the free ligand with glucuronic acid; and (iii) separation of the antibody-bound and free ligand by partition of the reactants into an organic and aqueous phase. The technique has been called ligand differentiation immunoassay (LIDIA). The mean sensitivity was 5 pg/tube (equivalent to 0.35 nmol/l female plasma; 0.87 nmol/l male plasma). The mean reagent blank (+/- SD) was 0.24 (0.12) nmol/l female plasma; 0.61 (0.30) nmol/l male plasma. A precision profile gave values less than 50%; the within batch variation was less than 8.3% and the between batch variation over three months was 12.3%. An accuracy profile between the second and penultimate points on the calibration curve gave values between 77 and 103%. The correlation coefficient 'r' between LIDIA and a heterogeneous radioimmunoassay was 0.92 when applied to plasma from men and 0.95 to samples from women.

A PROFOMWANDHOCHARLESO. "Daudi K Langat , Pedro J Morales , Charles O Omwandho , Asgerally T Fazleabas and Joan S Hunt, Polymorphisms in Paan-AG promoter influences NF-kB binding and transcription activity in HEK293 cells.". In: The Journal of Immunology 2007, 178: 42.12.; 2007. Abstract

HLA-G is a protein highly expressed at the human maternal-fetal interface during pregnancy. It is thought to be critical for the survival of the semi-allogenic fetus. The baboon (Papio anubis) expresses an HLA-G-like protein termed Paan-AG in the placenta, and may serve as a model for HLA-G studies. Paan-AG shares many characteristics with HLA-G, including alternative splicing of the mRNA and restricted tissue expression of the protein. Our hypothesis is that the two genes share similar regulatory mechanisms. The objective of the current study was to assess binding of the transcription factor NF- B to Paan-AG B elements and determine the effects of binding on Paan-AG promoter activity. We assessed two Paan-AG alleles each containing two B elements, B1 and B2. NF- B bound both B1 and B2 elements in the AG1 allele. In contrast, only B1 of the AG-2 allele bound to NF- B; B2 did not bind. Mutagenesis studies showed that the difference in binding was due to two nucleotide differences in the 3' end of B1. The functional activity of the two alleles also differed; AG2 consistently showed higher luciferase activity compared to AG1. Mutating the last two nucleotides in the 3' end of B1 resulted in an increase of luciferase activity to levels comparable to that of AG2. Overall, these results suggest that variations in the proximal promoter may influence transcription rates of Paan-AG as reported recently for HLA-G, and provide further evidence of the potential usefulness of the baboon as a model for in vivo HLA-G studies.

A PROFOMWANDHOCHARLESO. "Tumbo-Oeri AG, Omwandho CA. Cellular and molecular interactions in HIV infections: a review.". In: East Afr Med J. 2002 May;79(5):249-53. w.; 2002. Abstract

OBJECTIVE: To review the cellular and molecular interactions between HIV and the host immune system that lead to full-blown AIDS. DATA SOURCES: Published reports on HIV/host interaction during a fifteen year period beginning from 1987. STUDY SELECTION: Only those studies involving humans and non-human primates were selected. The studies included original articles and state-of-the-art reviews covering in vivo and in vitro findings. DATA EXTRACTION AND SYNTHESIS: This article presents a critical review of the cellular and molecular mechanisms of HIV infection and their relationship to the onset of AIDS. CONCLUSION: HIV has elaborated diverse and somewhat complicated mechanisms for the subversion and evasion of the host immune defence strategies. These include escape through mutation, prolonged latency of the infection, masking of the viral envelope proteins, down-regulation of MHC-I and up-regulation of the Fas-ligand on infected cell surfaces. This review enhances our understanding of HIV/AIDS disease and presents a basis on which management strategies could be developed.

A PROFOMWANDHOCHARLESO. "Makawiti DW, Konji VN, Omwandho CA and Olowookere JO. Altered 3,5,3.". In: International Journal for Vitamin and Nutrition Research 65, 132-136.; 1995. Abstract

Immunoglobulins were eluted from ovine placentae and characterized by immunoprecipitation, electrophoresis, western blotting and ELISA.IgG was shown to comprise the bulk of placental-bound immunoglobulins while smaller amounts of IgM and only trace amounts of IgA were demonstrated.Results suggest that ovine placental IgG eluted by surgical cannulation of the uterine blood vessels in situ is similar to that eluted from postpartum placentae in vitro, implying that there may be some transfer of antibodies across the maternal side of the placental barrier to the trophoblast.These antibodies are rich in IgG1 and IgG2, have a relative molecular weight of 158 kDa, and bind to an 80 kDa peptide prepared from pre-acidified ovine placental cotyledons.We propose that the binding of placental IgG to the 80 kDa antigen may prevent immunological rejection of the foetus by competitively excluding cytotoxic cells of maternal origin such as NK cells.Also, given that a similar antigen (80 kDa) has been reported in humans and equines, and shown to be saturated with IgG in term placentae, we propose that this antigen may be conserved in several mammalian species for reproductive purpose.Consequently, we suggest that the ovine placental IgG and the 80 kDa antigen may be suitable as models for the study of maternal-foetal interactions in mammalian pregnancies.

A DROBONDOANNE, M PROFNDETEIDAVID. "Mrumbi K, Obondo A.A, Rono R, Ngare D, & Ndetei D.M. .". In: In Eds. Ndetei et al (2006). International Psychiatry Vol.6 No. 1; 2006.
A DRMASIGAMARY. "Masiga, M.A. Sociodemographic characteristic and clinic features among patients attending a private paediatric clinic in Nairobi, Kenya E.A Med. J. 2004: 8 ; 577 .". In: East Afr Med J. 2004 Nov;81(11):577-82. University of Nairobi.; 2004. Abstract
Department of Paediatric Dentistry/Orthodontics, Faculty of Dental Sciences, University of Nairobi, PO Box 19676, Nairobi, Kenya. OBJECTIVES: To evaluate the socio-demographic characteristics, chief complaints and clinical presentation of children attending a private dental clinic in Nairobi, Kenya. DESIGN: A retrospective survey of dental clinic records. SETTING: A private dental clinic in Nairobi, Kenya. SUBJECTS: All patients aged 0-18 years who were first-time attenders at the dental clinic during a three year period. RESULTS: The records of 800 patients were examined, comprising 395 males and 405 female children. The average age was 7.2 years (95%CI, 6.9-7.4). Referral to the clinic for treatment was mostly by self (81.4%). Most patients (57.9%) were self-sponsored for their dental treatment. Majority of the patients attending (86.8%) did not clinically have any underlying medical conditions. The major complaints for most patients were dental decay (27.4%) and dental pain (21.6%). Very few children (7.6%) attended for dental check-up. Five hundred and forty nine (68.6%) of the children suffered from dental decay while 294 (36.8%) suffered from gingivitis. The average number of teeth decayed was 4.02, SD +/- 2.4 (95% CI 3.8-4.2). Most carious lesions occurred in the younger children. There was a significant increase in the occurrence of decay over the three year period of the study. Significantly higher levels of gingivitis was observed in the prepubertal and pubertal age group. Attendance for traumatic injuries was relatively low with only 46 (5.8%) children reporting traumatic injuries to their dentitions. Most traumatic injuries involved the anterior teeth as a result of falls. Treatment given at the first visit was mainly restorative (28.6%) followed by dental extractions (25.4%). CONCLUSION: The average are of patients attending the clinic was 7.2 years. Interdisciplinary referral was low since most patients were self-referred and self sponsored for treatment. Dental caries was prevalent, necessitating a high demand for restorative treatment. Although gingivitis was less prevalent, it was significant among children in the prepubertal years.
A MRKABURIAHF. "Study of the Microbiologigal quality of processed Kenyan honey. A preliminary report. Bull. Anim. Hlath. Prod. Afr. 1989. Special issue p. 203-206.". In: journal. GIGA German Institute of Global and Area Studies, Hamburg, July 2009; 1989. Abstract
A preliminary study of microbiological quality of honey was carried out using 26 samples obtained from the National Bee Keeping Research Station. Total viable counts (TVC) of aerobic bacteria, yeasts and moulds, and Clostridium species were done. Of the 26 samples, 24 (92.3%) had a TVC ranging from 3 x10 -87 x 10 colony forming units (cfu) per gram of honey. Two samples did not yield any microorganisms. Of the 24 positive samples, 9 (37.5%) were found to contain Clostridium species per gram while eight (33.3%) were positive for moulds with counts ranging from 10-100 c.f.u / g. No yeasts were detected. In addition, three samples yielded the three types of microorganisms.
A DRODHIAMBOWALTER. "W Odhiambo, Guthua SW, Saoke P. One Bullet Story: Public Health Consequences of Small arms injuries: The role of public health in the prevention of war related injuries, June, 2004. www.ippnw.org. W Odhiambo, HIV/AIDS and debt crises; Threat to Human Surv.". In: Int J Prosthodont. 2004 Jul-Aug;17(4):464-8. IPPNW; 2004. Abstract

OBJECTIVE: To determine the pattern and characteristics of patients admitted with firearm injuries (FAIs) and establish the morbidity and mortality associated with these injuries. DESIGN: Retrospective cross-sectional study. SETTING: Kenyatta National Hospital (KNH), January 2004 to December 2005. SUBJECTS: All patients admitted with physically evident firearm injury. RESULTS: There were a total of 717 patients recorded with FAIs constituting 0.6% of the total number of patients seen in the casualty. Of these, 421 (58.7%) were admitted and treated as in- patients. A firearm was used in 6.7% of the 6300 assault cases recorded in 2004 and in 9.7% of the 3079 cases recorded in 2005. The increase from 6.7% in 2004 to 9.7% in 2005 was statistically significant (p < 0.05). There were 370 (87.9%) males and 49 (11.6%) females giving a male to female ratio of 7.5:1. The mean age was 29.7 +/- 10.9 years with a range of 3 to 66 years. At least 262 (62.2%) of the 421 admitted FAI casualties were treated under general anaesthesia (GA). The average duration of operation per patient was 2 +/- 1.5 hours. CONCLUSION: FAIs are on the increase and affect all age groups but is largely a disease of a young male adult in the 3rd and 4th decade of life. Mortality is higher with increasing age while female victims are fewer but on average six years younger than males. The lower extremities are the commonest target among the survivors. However, abdominal wounds tend to be the most lethal, accounting for greater mortality.

A MRMUTULIDANIEL, A MRMUTULIDANIEL. "Mutuli, D.A. (1990) An Investigation into the effect of Cultivator Design on seedbed preparation . Proceedings of the Annual Postgraduate Research Conference, University of Newcastle Upon Tyne, England.". In: World Employment Programme Research Working Papers, No. 45. Geneva: International Labour Office. Cambridge: Cambridge University Press.; 1990. Abstract

A description is given of a novel liquid phase immunoassay for the measurement of testosterone in peripheral venous plasma from men and women. The procedure involves: (i) competitive binding of the analyte and tritiated antigen to specific antibodies; (ii) enzymatic conjugation of the free ligand with glucuronic acid; and (iii) separation of the antibody-bound and free ligand by partition of the reactants into an organic and aqueous phase. The technique has been called ligand differentiation immunoassay (LIDIA). The mean sensitivity was 5 pg/tube (equivalent to 0.35 nmol/l female plasma; 0.87 nmol/l male plasma). The mean reagent blank (+/- SD) was 0.24 (0.12) nmol/l female plasma; 0.61 (0.30) nmol/l male plasma. A precision profile gave values less than 50%; the within batch variation was less than 8.3% and the between batch variation over three months was 12.3%. An accuracy profile between the second and penultimate points on the calibration curve gave values between 77 and 103%. The correlation coefficient 'r' between LIDIA and a heterogeneous radioimmunoassay was 0.92 when applied to plasma from men and 0.95 to samples from women.

A PROFOMWANDHOCHARLESO. "Charles O.A. Omwandho, Susanne E. Gruessner, John Falconer, Hans Rudolf Tinneberg, Timothy K. Roberts. IS INTRAVENOUS IMMUNOGLOBULIN A MULTI-HEAD MAGIC BULLET?". In: 5th International Congress of the African Association of Physiological Sciences (AAPS).; 2008. Abstract
n/a
A B, E O, P M, M N, Y M, Kiambi S, Muturi M, Mwatondo A, Muriithi R, Cleaveland S, Hampson K, MK N, M KP, M TS. "A hundred years of rabies in Kenya and the strategy for eliminating dog-mediated rabies by 2030." AAS Open Res. 2019;1:23.
A AH, Emily R, TM O, Ndaguatha PLW. "HER2/Neu Protein Over-Expression in Patients with Gastric and Gastro- Esophageal Junction Carcinoma Seen at Kenyatta National Hospital, Kenya." Journal of Carcinogenesis & Mutagenesis. 2014;5(186):doi: 10.4172/2157-2518.1000186.
A PROFOMWANDHOCHARLESO. "S. Gressner, C. A. Omwandho, V. Klingmueller, R. M. Bohle (2004): Effect of intermittent uterine occlusion on hemodynamic changes in pre-term and near term ovine twin fetuses .". In: Ultrasound in Obstetrics and Gynecology 24:341.; 2004. Abstract

Recurrent pregnancy loss has been associated with autoimmune responses to membrane phospholipids and alloimmune reactions against paternally derived molecules on the trophoblast. The problem is psychologically and economically stressful as it undermines the capacity of some couples to reproduce and participate effectively in the day-to-day economic activities. This article reviews the adoption of intravenous immunoglobulin as a form of therapy for the clinical management of recurrent pregnancy loss and of selected autoimmune disorders. Side effects, contraindications and safety of use are discussed.

A MRSOMBOKMARGARET. "Business Plan, a manual for Higher Diploma in entrepreneurship ILO, UNDP.". In: The Kenya Times (Nairobi: November 27,1983), p.6. Journal of Mathematics and Mathematical Sciences(PMMS); 1993. Abstract
This article reveals that the concept of education as a process of growth is a difficult one. Philosophers are, therefore, justified in being weary when pondering over its meaning, both in theory and practice. By way of conclusion, the article appreciates the complexities inherent in the growth theory of education, summarizing its major strength and weaknesses. Then it cautions educational planners and practitioners to be weary when, and if, they translate the theory into practice, so that they utilize the strengths inherent in the theory whilst paying attention to the dangers of its inherent weaknesses.
A PROFOMWANDHOCHARLESO. "Omwandho CA. Ovine placental Immunoglobulins: purification, partial characterization and some in vitro Biological Activities.". In: Ph.D Thesis - 1996.; 1996. Abstract

Immunoglobulins were eluted from ovine placentae and characterized by immunoprecipitation, electrophoresis, western blotting and ELISA.IgG was shown to comprise the bulk of placental-bound immunoglobulins while smaller amounts of IgM and only trace amounts of IgA were demonstrated.Results suggest that ovine placental IgG eluted by surgical cannulation of the uterine blood vessels in situ is similar to that eluted from postpartum placentae in vitro, implying that there may be some transfer of antibodies across the maternal side of the placental barrier to the trophoblast.These antibodies are rich in IgG1 and IgG2, have a relative molecular weight of 158 kDa, and bind to an 80 kDa peptide prepared from pre-acidified ovine placental cotyledons.We propose that the binding of placental IgG to the 80 kDa antigen may prevent immunological rejection of the foetus by competitively excluding cytotoxic cells of maternal origin such as NK cells.Also, given that a similar antigen (80 kDa) has been reported in humans and equines, and shown to be saturated with IgG in term placentae, we propose that this antigen may be conserved in several mammalian species for reproductive purpose.Consequently, we suggest that the ovine placental IgG and the 80 kDa antigen may be suitable as models for the study of maternal-foetal interactions in mammalian pregnancies.

A N, GO O, C O. "The use of musculoskeletal ultrasound of the wrist and hand in the assessment of treatment response in rheumatoid arthritis patients." Afr J Rheumatol. 2020;8(1):3-7. Abstract

Objective: Rheumatoid arthritis is a
debilitating disease with accrual of joint damage during each flare of the disease that progresses to considerable functional disability. Early treatment is
thus aimed to achieve remission status so as to reduce the progression of joint
damage. Currently the disease activity parameter DAS28 (amongst others)
is used to define a remission status and thus demonstrate the efficacy
of a treatment regimen, however musculoskeletal ultrasound (MSUS) is
proving to be superior at determining the amount of inflammation within joints by grading synovial hypertrophy and neo-vascularization of the
inflamed synovium. This article is thus intended to shed light on the usefulness of musculoskeletal ultrasound
both greyscale and Doppler in the determination of treatment response
in rheumatoid arthritis patients. Design: This article will elaborate
the importance and effectiveness of musculoskeletal ultrasound. Thus it will involve a discussion on the need for an effective tool to detect inflammatory activity, the ability of ultrasound to detect and grade the disease activity i.e.
being sensitive to change, the various scoring systems currently used, and
lastly a comparison of musculoskeletal ultrasound to other modalities and
clinical and serological evaluation. Data source and extraction:
Published studies, reviews and guidelines regarding the use of
musculoskeletal ultrasound of the wrist/hand in assessing treatment
response in rheumatoid arthritis patients were sourced through the
internet and library searches and the relevant data extracted. Conclusion:
status of the patient or a high initial ESR with significant serological and clinical
improvement, which will again not be portrayed in the DAS28 results. There may also be variability when assessing joints that are swollen or tender in between different examiners4. Moreover, there is a subset of
patients who still have disease progression despite achieving clinical remission status5.
  Magnetic Resonance Imaging (MRI) and radiographic evaluation have also been used as adjuncts to clinical exam but both have their drawb

A DROBONDOANNE, M PROFNDETEIDAVID. "Rono R, Onem T, Kilonzo G, Ndetei D.M, Obondo A.A. .". In: In Eds. Ndetei et al (2006). International Psychiatry Vol.6 No. 1; 2006.
A 8. TSR &. "Ulimwengu wa Kanga." The University of Nairobi Journal of Language and Linguistics . 2016;5(2224-1655):195-203 .
A MRKABURIAHF. "On-Farm cross-section Survey for bovine Fascilosis in Kenya. Bull. Anim. Hlth. Prod. Afr. (1997). 45: 251-157.". In: Biennial Scientific Conference of the Faculty of Veterinary Medicine, August 30th-31st, 2000. GIGA German Institute of Global and Area Studies, Hamburg, July 2009; 1997. Abstract
This integrative review on the teaching of reading in Kenyan primary schools provides a foundation for the growing movement there to improve reading education. In gathering sources for this review, we took an inclusive historical stance. Thus, we did not dismiss research reports that lacked traditional indicators of quality such as being published in peer-reviewed journals. We used multiple methods to find relevant research and associated documents, including two trips to Kenya. The review is organized by six topics: (a) language of instruction, (b) reading instruction, (c) reading materials, (d) reading culture, (e) assessment, and (f) teacher development. The review concludes with six proposals for policymakers, educational researchers, and teacher educators for the development of reading instruction based on what we learned in reviewing the literature. The first proposals are intended specifically to address the teaching of reading in Kenya, but they may be relevant to other sub-Saharan nations. The final proposal encourages others to conduct similar reviews to make possible a handbook of reading in Africa.
A K, CA MOTURI. A Framework for Knowledge Management of Wildlife Research in Kenya. KICC, Nairobi, Kenya: AIBUMA; 2011.
A DRODHIAMBOWALTER. "F.G.F Hugenberg, W.A Odhiambo A. Mwita and D. Opondo:Firearm injuries in Nairobi, Kenya; Who pays the Price? Journal of Public Health Policy 2007, 28: 4.410.". In: Journal of Public Health Policy. Journal of Public Health Policy; 2007. Abstract

OBJECTIVE: To determine the pattern and characteristics of patients admitted with firearm injuries (FAIs) and establish the morbidity and mortality associated with these injuries. DESIGN: Retrospective cross-sectional study. SETTING: Kenyatta National Hospital (KNH), January 2004 to December 2005. SUBJECTS: All patients admitted with physically evident firearm injury. RESULTS: There were a total of 717 patients recorded with FAIs constituting 0.6% of the total number of patients seen in the casualty. Of these, 421 (58.7%) were admitted and treated as in- patients. A firearm was used in 6.7% of the 6300 assault cases recorded in 2004 and in 9.7% of the 3079 cases recorded in 2005. The increase from 6.7% in 2004 to 9.7% in 2005 was statistically significant (p < 0.05). There were 370 (87.9%) males and 49 (11.6%) females giving a male to female ratio of 7.5:1. The mean age was 29.7 +/- 10.9 years with a range of 3 to 66 years. At least 262 (62.2%) of the 421 admitted FAI casualties were treated under general anaesthesia (GA). The average duration of operation per patient was 2 +/- 1.5 hours. CONCLUSION: FAIs are on the increase and affect all age groups but is largely a disease of a young male adult in the 3rd and 4th decade of life. Mortality is higher with increasing age while female victims are fewer but on average six years younger than males. The lower extremities are the commonest target among the survivors. However, abdominal wounds tend to be the most lethal, accounting for greater mortality.

A MRMUTULIDANIEL, A MRMUTULIDANIEL. "Mutuli, D.A. (1994) Some Engineering opportunities for the Sustainable Development of African Agriculture. Proceedings of the FAOE/IEK All African Engineers Conference, December,.". In: World Employment Programme Research Working Papers, No. 45. Geneva: International Labour Office. Cambridge: Cambridge University Press.; 1994. Abstract

A description is given of a novel liquid phase immunoassay for the measurement of testosterone in peripheral venous plasma from men and women. The procedure involves: (i) competitive binding of the analyte and tritiated antigen to specific antibodies; (ii) enzymatic conjugation of the free ligand with glucuronic acid; and (iii) separation of the antibody-bound and free ligand by partition of the reactants into an organic and aqueous phase. The technique has been called ligand differentiation immunoassay (LIDIA). The mean sensitivity was 5 pg/tube (equivalent to 0.35 nmol/l female plasma; 0.87 nmol/l male plasma). The mean reagent blank (+/- SD) was 0.24 (0.12) nmol/l female plasma; 0.61 (0.30) nmol/l male plasma. A precision profile gave values less than 50%; the within batch variation was less than 8.3% and the between batch variation over three months was 12.3%. An accuracy profile between the second and penultimate points on the calibration curve gave values between 77 and 103%. The correlation coefficient 'r' between LIDIA and a heterogeneous radioimmunoassay was 0.92 when applied to plasma from men and 0.95 to samples from women.

A PROFODHIAMBOJACK. "Understanding Philosophy: A text for science based students of Philosophy - 1993.". In: J Obst Gynecol East Cent. Afric. DR. MARK NELSON AWORI; PROF. PANKAJ G. JANI; 1993. Abstract
Twenty variceal banding sessions were performed in eight patients between February 1995 and September 1996. A total of 69 rings were used to band the varices and at each session between two to six rings were used. Two of the eight had active bleeding and both underwent variceal banding to successfully arrest their bleeding as inpatients. Sixteen other variceal banding sessions were performed on an outpatient basis to obliterate their varices. Four of the eight patients had had sclerotherapy before and varices were still present. No acute or long term complications were noted. In one patient, variceal banding could not be performed as he developed stridor upon placement of the overtube. All the patients had advanced varices (Grade III or IV) and extended for more than 15 cms in the oesophagus. Endoscopic variceal obliteration remains the treatment of choice for patients with portal hypertension with variceal bleeding. Variceal banding is associated with a superior outcome when compared with sclerotherapy; the variceal kill time is shorter, infective complications less, rebleeding occurs less commonly and transfusion requirements are lower.
A PROFOMWANDHOCHARLESO. "Charles O.A. Omwandho1 , Lutz Konrad 2, Gulden Halis3,4, Frank Oehmke 2 and Hans-Rudolf Tinneberg 2 1Department of Biochemistry, University of Nairobi,Nairobi, Kenya. 2Department of Gynecology ond Obstetrics, klinskstr. 32, 35392 Giessen, Germany 3Fertili.". In: http://biochem.uonbi.ac.ke/sites/default/files/chs/medschool/biochem/Role%20of%20FGF-Bs%20in%20normal%20human%20endometrium%20and%20endometriosis1.doc.; 2009. Abstract
A PROFOMWANDHOCHARLESO. "Gruessner S 1, Omwandho C. A. O. 1, V. Klingmueller 2, Bohle R. 3, Tinneberg H.R 1. 2D .". In: Ultrasound in Medicine 2004 Okt; Vol 25 (Suppl 1).; 2004. Abstract

1 Universit

UoN Websites Search