Daily co-trimoxazole prophylaxis to prevent mortality in children with complicated severe acute malnutrition: a multicentre, double-blind, randomised placebo-controlled trial

Citation:
Berkley JA, Ngar M, JT, Mutai B, KA. "Daily co-trimoxazole prophylaxis to prevent mortality in children with complicated severe acute malnutrition: a multicentre, double-blind, randomised placebo-controlled trial ." Lancet Glob Health . 2016;4:464-73.

Abstract:

Children with complicated severe acute malnutrition (SAM) have a greatly increased risk of mortality
from infections while in hospital and after discharge. In HIV-infected children, mortality and admission to hospital
are prevented by daily co-trimoxazole prophylaxis, despite locally reported bacterial resistance to co-trimoxazole. We aimed to assess the efficacy of daily co-trimoxazole prophylaxis on survival in children without HIV being treated for complicated SAM

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