Bio

Dr. Boniface Mwanzia Kavoi Bio

After graduating with a Bachelors degree in Veterinary Medicine from the University of Nairobi in November 1998, Dr. Kavoi registered with the Kenya Veterinary Board and began private clinical practice in Machakos and Makueni Counties in Kenya. He at the same time served as a teacher (Chemistry & Biology) in Masii S.D.A Secondary School in Machakos County. In 2001, Dr.

Publications


2014

Kavoi, BM, Plendl J, Makanya AN, Ochieng’ S, Kiama SG.  2014.  Effects of Anticancer Drug Docetaxel on the Structure and Function of the Rabbit Olfactory Mucosa. Tissue & Cell. 46:213-224. Abstracteffects_of_anticancer_drug_docetaxel_on_the_structure_and_function_of_the_rabbit_olfactory_mucosa.docxeffects_of_anticancer_drug_docetaxel_on_the_structure_and_function_of_the_rabbit_olfactory_mucosa.pdf

Docetaxel (DCT) is an anticancer drug which acts by disrupting microtubule dynamics in the highly mitotic cancer cells. Thus, this drug has a potential to affect function and organization of tissues exhibiting high cellular turnover. We investigated, in the rabbit, the effects of a single human equivalent dose (6.26 mg/kg, i.v.) of DCT on the olfactory mucosa (OM) through light and electron microscopy, morphometry, Ki-67 immunostaining, TUNEL assay and the buried food test for olfactory sensitivity. On post-exposure days (PED) 5 and 10, there was disarrangement of the normal cell layering in the olfactory epithelium (OE), apoptotic death of cells of the OE, Bowman’s glands and axon bundles, and the presence (including on PED 3) of blood vessels in the bundle cores. A decrease in bundle diameters, olfactory cell densities and cilia numbers, which was most significant on PED 10 (49.3%, 63.4% and 50%, respectively), was also evident. Surprisingly by PED 15, the OM regained normal morphology. Furthermore, olfactory sensitivity decreased progressively until PED 10 when olfaction was markedly impaired, and with recovery from the impairment by PED 15. These observations show that DCT transiently alters the structure and function of the OM suggesting a high regenerative potential for this tissue

Gakuya, DW, Mbugua PN, Kavoi BM, Kiama SG.  2014.  Effect of Supplementation of Moringa oleifera Leaf Meal in Broiler Chicken Feed.. International Journal of Poultry Science . 13:208-213.

2012

KAVOI M. BONIFACE ET AL..  2012.  Anticancer Drug Vinblastine Sulphate Induces Transient Morphological Changes on the Olfactory Mucosa of the Rabbit. Anatomia Histologia Embryologia. 41:374-387,2012.
KAVOI M. BONIFACE ET AL..  2012.  Morpho-functional Adaptations of the Olfactory Mucosa in Postnatally Developing Rabbits. Anatomical Record. 295:1352-1363.

2011

Kavoi, B.M, ETAL.  2011.  Comparative Morphometry of the Olfactory Bulb, Tract and Stria in the Human, Dog and Goat, 11 Feb, 2011. The 10th International Conference of the Society of Neuroscientists of Africa “Topics in Neuroscience: Basic to Clinic. , University of Addis Ababa, Addis Ababa, Ethiopia
MAKANYA N. ANDREW, KAVOI M. BONIFACE ET AL..  2011.  Spatial and functional relationships between air conduits and blood capillaries in the pulmonary gas exchange tissue of adult and developing chickens. Microscopy Research and Technique . 74:159-169.: Andrew N. Makanya, Yosif El-Darawish, Boniface M. KavoiWebsite
KAVOI M. BONIFACE ET AL..  2011.  Comparative Morphometry of the Olfactory Bulb, Tract and Stria in the Human, Dog and Goat. International Journal of Morphology. 29:939-946.: Boniface Kavoi & Hassanali JameelaWebsite

2010

Kavoi, B.M, ETAL.  2010.  Olfactory Mucosa after Administration of Vinblastine Sulphate in Adult Rabbits., 7 Dec 2010. 2nd International Conference on Neuroinfection and World Impact. , University of St. Denis, Reunion Island
KAVOI M. BONIFACE ET AL..  2010.  Comparative functional structure of the olfactory mucosa in the domestic dog and sheep. Annals of Anatomy. 192:329–337.: Boniface Kavoi, Andrew Makanya, Jameela Hassanali, Hans-Erik Carlsson, Stephen Kiama AbstractWebsite

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Olfactory acuity differs among animal species depending on age and dependence on smell. However, the attendant functional anatomy has not been elucidated. We sought to determine the functional structure of the olfactory mucosa in suckling and adult dog and sheep. Mucosal samples harvested from ethmoturbinates were analyzed qualitatively and quantitatively. In both species, the olfactory mucosa comprised olfactory, supporting and basal cells, and a lamina propria containing bundles of olfactory cell axons, Bowman’s glands and vascular elements. The olfactory cells terminated apically with an expanded knob, from which cilia projected in a radial fashion from its base and in form of a tuft from its apex in the dog and the sheep respectively. Olfactory cilia per knob weremorenumerous in the dog (19±3) compared to the sheep (7±2) (p < 0.05). In the dog, axonal bundles exhibited one to two centrally located capillaries and the bundles were of greater diameters (73.3±10.3_m) than those of the sheep (50.6±6.8_m), which had no capillaries. From suckling to adulthood in the dog, the packing density of the olfactory and supporting cells increased by 22.5% and 12.6% respectively. Surprisingly in the sheep, the density of the olfactory cells decreased by 26.2% while that of the supportive cells showed no change. Overall epithelial thickness reached 72.5±2.9_m in the dog and 56.8±3.1_m in the sheep. These observations suggest that the mucosa is better structurally refined during maturation in the dog than in the sheep.

2008

Kavoi M.B. ET AL..  2008.  A Comparative Study of the Olfactory Mucosa in the Dog and the Sheep, Sept. 19, 2008. the 6th Faculty of Veterinary Medicine Biennial Scientific Conference . , Upper Kabete Campus, University of Nairobi
Kavoi M.B ET AL..  2008.  Morphometric Comparisons of the Olfactory Mucosa in Suckling and Adult dogs, Sept. 19, 2008. The 6th Faculty of Veterinary Medicine Biennial Scientific Conference . , Upper Kabete Campus, University of Nairobi
KAVOI, BONIFACE.  2008.  Comparative Morphology and Morphometry of the Olfactory Mucosa in the Domestic Dog and Sheep. : MSc Thesis, University of Nairobi

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