Prevention of hearing loss in experimental pneumococcal meningitis by administration of dexamethasone and ketorolac. J Infect Dis. 1999 Jan;179(1):264-8. Erratum in: J Infect Dis 1999 Mar;179(3):753.

Citation:
M PROFBHATTSHRIKANTBABU. "Prevention of hearing loss in experimental pneumococcal meningitis by administration of dexamethasone and ketorolac. J Infect Dis. 1999 Jan;179(1):264-8. Erratum in: J Infect Dis 1999 Mar;179(3):753.". In: J Infect Dis. 1999 Jan;179(1):264-8. Erratum in: J Infect Dis 1999 Mar;179(3):753. Taylor & Francis; 1999.

Abstract:

{ Pneumococcal meningitis remains a significant cause of morbidity, particularly sensorineural hearing loss. Recent literature has suggested that a vigorous host immune response to Streptococcus [corrected] pneumoniae is responsible for much of the neurologic sequelae, including deafness, after bacterial meningitis. This study used a rabbit model of hearing loss in experimental pneumococcal meningitis to evaluate the therapeutic effect of two anti-inflammatory agents, dexamethasone and ketorolac, coadministered with ampicillin. Both adjunctive drugs minimized or prevented sensorineural hearing loss compared with placebo. Dexamethasone, administered 10 min before ampicillin, was particularly effective in minimizing mean hearing threshold change compared with placebo for both clicks (dexamethasone: 6.7-dB sound pressure level [SPL] vs. placebo: 33. 4-dB SPL

Notes:

n/a

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