F.S. Rana, M.P. Hawken, C. Mwachari, Bhatt S.M., F. Abdullah, L.W. Nganga, C. Power, W.A. Gitui, J.D.H. Porter and S.B. Lucas. Autopsy study of HIV-I positive and HIV-negative adult medical patients in Nairobi Kenya. Journal of Aquired Immune Deficiency S

Citation:
M PROFBHATTSHRIKANTBABU. "F.S. Rana, M.P. Hawken, C. Mwachari, Bhatt S.M., F. Abdullah, L.W. Nganga, C. Power, W.A. Gitui, J.D.H. Porter and S.B. Lucas. Autopsy study of HIV-I positive and HIV-negative adult medical patients in Nairobi Kenya. Journal of Aquired Immune Deficiency S.". In: Journal of Aquired Immune Deficiency Syndrome 2000; vol. 24, 23 . Taylor & Francis; 2000.

Abstract:

Bloodstream infections are a frequent complication in human immunodeficiency virus (HIV)-infected adults in Africa and usually associated with a poor prognosis. We evaluated bloodstream infections across a decade in 3 prospective cross-sectional surveys of consecutive medical admissions to the Kenyatta National Hospital, Nairobi, Kenya. Participants received standard clinical care throughout. In 1988-1989, 29.5% (28 of 95) of HIV-positive patients had bloodstream infections, compared with 31.9% (46 of 144) in 1992 and 21.3% (43 of 197) in 1997. Bacteremia and mycobacteremia were significantly associated with HIV infection. Infections with Mycobacterium tuberculosis, non-typhi species of Salmonella (NTS), and Streptococcus pneumoniae predominated. Fungemia exclusively due to Cryptococcus neoformans was uncommon. Clinical features at presentation remained similar. Significant improvements in the survival rate were recorded among patients with NTS bacteremia (20%-83%; P<.01) and mycobacteremia (0%-73%; P<.01). Standard clinical management can improve outcomes in resource-poor settings.

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