Publications

Found 50496 results

Sort by: Author Title Type [ Year  (Asc)]
2021
Onyango AE, Okoth MW, Kunyanga CN. "Water Disinfection Techniques: A review." Journal of Engineering in Agriculture and the Environment. 2021;7(1):54-78.
Missiame A, Nyikal RA, Irungu P. "What is the impact of rural bank credit access on the technical efficiency of smallholder cassava farmers in Ghana? An endogenous switching regression analysis." Heliyon . 2021;7(5). AbstractWebsite

Abstract
This paper assesses the impact of access to credit from rural and community banks (RCBs) on the technical efficiency of smallholder cassava farmers in Ghana. The study employed the stochastic frontier, and endogenous switching regression models to estimate the technical efficiency, and the impact of RCB credit access, respectively, on a randomly selected sample of 300 smallholder cassava farmers in the Fanteakwa District of Ghana. Results suggest that cassava farmers in the District are 70.5 percent technically efficient implying that cassava yield levels could be increased further by 29.5 percent without changing the current levels of inputs. The results further reveal that the gender of the household head, access to extension services, membership in farmer organizations, and proximity to the bank are the major factors that positively influence farmers to access credit from RCBs. On average, farmers who accessed credit from RCBs have significantly higher technical efficiencies than farmers who did not access, suggesting that access to credit from RCBs positively impacts the technical efficiency of smallholder cassava farmers.

Keywords: Credit access; Endogenous switching regression; Rural and community banks; Stochastic frontier model; Technical efficiency.

MK N, J D, M N, et al. "Why is There Low Morbidity and Mortality of COVID-19 in Africa." Am J Trop Med Hyg. 2021;10.4269/ajtmh.20-0474.
Moturi CA, Okemwa VO, Orwa DO. "Why the Insurance Sector Needs Big Data Analytics Capability for Digital Transformation." International Journal of Big Data Management. 2021. Abstract

In order for organisations to generate competitive advantages from big data investments, they need to acquire a unique blend of technology, human skills, financial resources and a data-driven culture. Organisations need to measure their big data analytics capability in order to yield competitive performance. This study sought to examine the relationship between a firms big data analytics capability (BDAC) and competitive performance through mediating role of dynamic and operational capabilities. To test the proposed research model, we used survey data from 110 employees across 54 insurance companies in Kenya. Using partial least squares structural equation modelling, the results provide evidence that BDAC leads to superior firm performance. Various resources that form big data analytics (BDA) capability have been identified and an instrument to measure BDAC proposed. The findings from this study provides a roadmap strategy for implementing BDA projects.

Nyawade SO, Gitari HI, Karanja NN, Gachene CKK, Schulte-Geldermann E, Parker ML. "Yield and evapotranspiration characteristics of potato-legume intercropping simulated using a dual coefficient approach in a tropical highland." Field Crops Research . 2021;274 :108327.
Osaaji MG, Odari M, Muchiri J. "“From Alterity to Agency: Pathways of Subversion and Resistance in Ngugi Wa Thiong’o’s Personal Essays”. ." The Journal of Language, Technology & Entrepreneurship in Africa (JOLTE). . 2021;11 no. 2(2021):1-16.
"“Reflections on the Detective Novel as an Allegory of Contemporary Kenya.”." Journal of Language, Technology& Entrepreneurship in Africa. 2021;12(1):17-35.
Alade K, Windapo A, Wachira-Towey IN. "• Rethinking leadership in the fourth industrial revolution :lessons for construction business organizations." Journal Of Leadership Studies. 2021;Volume 15(1).
Maingey Y, Opondo M, Olago D, Ouma G. "{The impacts of increasing water scarcity and the potential for water-related conflict in Lamu, Kenya}." Water Supply. 2021;22:1983-1994. AbstractWebsite

{In the age of climate change, the efficient allocation, distribution and use of water raises complex issues for water management, with far-reaching and often contentious consequences. As water becomes scarcer, water-related tensions are imminent on different scales. It is the interplay of these tensions with a number of socioeconomic, political, environmental and cultural factors that determine the probability of conflict. Lamu, found in the coastal part of Kenya, is a unique location in that access to water is already a major challenge. Combined with the negative impacts of climate change, and the ongoing large infrastructural development in the region, Lamu is on the verge of a water crisis. As such, there is a need for research into the context-specific factors that play a part in heightening the potential for water-related conflict amidst increasing water scarcity. The focus of this study was to identify and evaluate the context-specific factors that will amplify the potential for water-related conflict in Lamu. The findings suggest religion, migration, and poverty are factors that would heighten the potential for water-related conflict in the region amidst increasing water scarcity. The study recommends that these factors need to be addressed urgently and should be part of any water management mechanism in Lamu, in order to avoid water-related conflicts. Additionally, the findings imply that anticipating the stressors for water-related conflict in Lamu will play a significant role in managing conflict and facilitating negotiations over the region's water resources.}

MM B, M B, J F, EA L, A A, K A, GA B, WD B, E B, C C, H D, P D'A, L DC, N F, A M. "Diagnostic performance of a colorimetric RT -LAMP for the identification of SARS-CoV-2: A multicenter prospective clinical evaluation in sub-Saharan Africa." EClinicalMedicine. 2021. Abstract
n/a
Golden L, Chaya S, Reichmuth K, Visagie A, Ayuk A, Kwarteng Owusu S, Marangu D, Affendi N, Lakhan A, Gray D, Vanker A, Zar H, Zampoli M. "Aetiology and presentation of childhood pleural infections in the post-pneumococcal conjugate vaccine era in South Africa." Afr J Thorac Crit Care Med. 2021;27(4). Abstract

Complications of respiratory infections including pleural effusion (PE) are associated with a high morbidity. Differentiating between PE caused by (Mtb) infection and other bacterial infections in endemic areas is difficult in children, thus, impacting treatment.

Garelick S, Russell JM, Dee S, Verschuren D, Olago DO. "Atmospheric controls on precipitation isotopes and hydroclimate in high-elevation regions in Eastern Africa since the Last Glacial Maximum.". 2021;567:116984. AbstractWebsite

Tropical Africa experienced large changes in hydroclimatic conditions since the Last Glacial Maximum (LGM), ∼26.5 to 19 thousand years (ka or kyr) ago. The hydrogen isotopic composition of fossil leaf waxes (δDwax), assumed to record past variations in the hydrogen isotopic composition of precipitation (δDprecip), is increasingly being used to study past hydroclimatic change in Africa, and are commonly interpreted to reflect variation in the amount of precipitation through time (i.e., the amount effect). Although there are now many such δDprecip records from tropical Africa, there are few robust δDprecip records from easternmost equatorial Africa of sufficient length and resolution to evaluate the mechanisms governing hydroclimate variation during and since the LGM. We produced a new δDprecip record based on analyses of δDwax in sediment cores collected from Lake Rutundu, situated at an elevation of 3,078 meters above sea level (m asl) on Mt. Kenya. This record displays large variations in δDprecip corresponding with known climate events over the past 25 kyr, including D-enrichment during the Heinrich 1 stadial (H1) and the Younger Dryas (YD), and D-depletion during the Holocene portion of the African Humid Period (AHP). We also observe D-depletion during the LGM relative to the late Holocene, which, considering the amount effect, could be interpreted to imply that LGM climate conditions were wetter than today. However, because other hydroclimate proxies at this site indicate a drier LGM climate at Lake Rutundu, and since precipitation isotopes at this high-elevation site are likely influenced by different processes than at low elevations, we used a single-column Rayleigh distillation model to evaluate temperature and altitude-related effects on high-elevation δDprecip. This revealed that a change in the temperature lapse rate exerts strong control on δDprecip in this high-elevation setting, and that a steeper lapse rate could explain the observed D-depletion during the LGM at our site. Comparison of the Lake Rutundu δDprecip record with other leaf-wax based δDprecip records from East Africa indicates that changes in the meridional precipitation gradient associated with the mean annual position and intensity of the tropical rain belt, in turn driven by precessional insolation forcing, were likely a primary control on East African hydroclimate over the past 25 kyr, thereby contributing to overall regional drying during the LGM.

Garelick S, Russell JM, Dee S, Verschuren D, Olago DO. "Atmospheric controls on precipitation isotopes and hydroclimate in high-elevation regions in Eastern Africa since the Last Glacial Maximum.". 2021;567:116984. AbstractWebsite

Tropical Africa experienced large changes in hydroclimatic conditions since the Last Glacial Maximum (LGM), ∼26.5 to 19 thousand years (ka or kyr) ago. The hydrogen isotopic composition of fossil leaf waxes (δDwax), assumed to record past variations in the hydrogen isotopic composition of precipitation (δDprecip), is increasingly being used to study past hydroclimatic change in Africa, and are commonly interpreted to reflect variation in the amount of precipitation through time (i.e., the amount effect). Although there are now many such δDprecip records from tropical Africa, there are few robust δDprecip records from easternmost equatorial Africa of sufficient length and resolution to evaluate the mechanisms governing hydroclimate variation during and since the LGM. We produced a new δDprecip record based on analyses of δDwax in sediment cores collected from Lake Rutundu, situated at an elevation of 3,078 meters above sea level (m asl) on Mt. Kenya. This record displays large variations in δDprecip corresponding with known climate events over the past 25 kyr, including D-enrichment during the Heinrich 1 stadial (H1) and the Younger Dryas (YD), and D-depletion during the Holocene portion of the African Humid Period (AHP). We also observe D-depletion during the LGM relative to the late Holocene, which, considering the amount effect, could be interpreted to imply that LGM climate conditions were wetter than today. However, because other hydroclimate proxies at this site indicate a drier LGM climate at Lake Rutundu, and since precipitation isotopes at this high-elevation site are likely influenced by different processes than at low elevations, we used a single-column Rayleigh distillation model to evaluate temperature and altitude-related effects on high-elevation δDprecip. This revealed that a change in the temperature lapse rate exerts strong control on δDprecip in this high-elevation setting, and that a steeper lapse rate could explain the observed D-depletion during the LGM at our site. Comparison of the Lake Rutundu δDprecip record with other leaf-wax based δDprecip records from East Africa indicates that changes in the meridional precipitation gradient associated with the mean annual position and intensity of the tropical rain belt, in turn driven by precessional insolation forcing, were likely a primary control on East African hydroclimate over the past 25 kyr, thereby contributing to overall regional drying during the LGM.

Baba MM, Bitew M, Fokam J, Lelo EA, Ahidjo A, Asmamaw K, Beloumou GA, Bulimo WD, Buratti E, Chenwi C, Dadi H, D'Agaro P, De Conti L, Fainguem N, Gadzama G, Maiuri P, Majanja J, Meshack W, Ndjolo A, Nkenfou C, Oderinde BS, Opanda SM, Segat L, Stuani C, Symekher SL, Takou D, Tesfaye K, Triolo G, Tuki K, Zacchigna S, Marcello A. "Diagnostic performance of a colorimetric RT -LAMP for the identification of SARS-CoV-2: A multicenter prospective clinical evaluation in sub-Saharan Africa.". 2021;40:101101. Abstract1-s2.0-s2589537021003813-main-1.pdf1-s2.0-s2589537021003813-main-1.pdfWebsite

BackgroundManagement and control of the COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus SARS-CoV-2 is critically dependent on quick and reliable identification of the virus in clinical specimens. Detection of viral RNA by a colorimetric reverse transcription loop-mediated isothermal amplification (RT-LAMP) is a simple, reliable and cost-effective assay, deployable in resource-limited settings (RLS). Our objective was to evaluate the intrinsic and extrinsic performances of RT-LAMP in RLS.
Methods
This is a multicenter prospective observational study of diagnostic accuracy, conducted from October 2020 to February 2021 in four African Countries: Cameroon, Ethiopia, Kenya and Nigeria; and in Italy. We enroled 1657 individuals who were either COVID-19 suspect cases, or asymptomatic and presented for screening. RNA extracted from pharyngeal swabs was tested in parallel by a colorimetric RT-LAMP and by a standard real time polymerase chain reaction (RT-PCR).
Findings
The sensitivity and specificity of index RT LAMP compared to standard RT-PCR on 1657 prospective specimens from infected individuals was determined. For a subset of 1292 specimens, which underwent exactly the same procedures in different countries, we obtained very high specificity (98%) and positive predictive value (PPV = 99%), while the sensitivity was 87%, with a negative predictive value NPV = 70%, Stratification of RT-PCR data showed superior sensitivity achieved with an RT-PCR cycle threshold (Ct) below 35 (97%), which decreased to 60% above 35.
Interpretation
In this field trial, RT-LAMP appears to be a reliable assay, comparable to RT-PCR, particularly with medium-high viral loads (Ct < 35). Hence, RT-LAMP can be deployed in RLS for timely management and prevention of COVID-19, without compromising the quality of output.

Sura M, Osoti A, Gachuno O, Musoke R, Kagema F, Gwako G, Ondieki D, Ndavi PM, Ogutu O. "Effect of umbilical cord milking versus delayed cord clamping on preterm neonates in Kenya: A randomized controlled trial." PLoS One. 2021;16(1):e0246109. Abstract

Delayed cord clamping (DCC) is a placental to new-born transfusion strategy recommended by obstetric and gynaecological societies. Though not widely adopted, umbilical cord milking (UCM) may achieve faster transfusion when DCC cannot be performed such as when a neonate requires resuscitation.

Kaoga J, Olago D, Ouma G, Ouma G, Onono J. "The evolving cultural values and their implications on the Maasai Pastoralists, Kajiado County, Kenya.". 2021;13:e00881. AbstractWebsite

The Maasai pastoralists inhabiting Kajiado County have been known for their rich cultural values which have sustained their livelihoods. However, these cultural practices are evolving under the swift development context with the private holding of land becoming more prevalent. Before these disturbances, customary land was available for the Maasai pastoralists to carry out traditional production systems. The disturbance in their social-cultural ways following land fragmentation has rendered their traditional governance system untenable. Moreover, the Maasai pastoralists have been dispossessed from their customary land and social institutions which have shaped their customs. Thus, concerns have been raised over the sustenance of pastoralism considering that the required resources are either unavailable or not enough. To address this gap, there was the need to understand cultural adjustments and their impacts on the Maasai pastoralists’ societal needs. The study employed a cross-sectional design which consisted of 195 Household survey questionnaires, 8 Focus Group Discussions and 18 Key Informant Interviews. The qualitative and quantitative data from the study were summarized and thematic perceptions generated. The results of this study revealed the uniqueness of the Maasai pastoralists’ traditional social structures. Also highlighted by the study was the erosion of the traditional social relations exposing the Maasai pastoralists to increasing vulnerability. These findings support the need for external support to supplement the traditional coping strategies to balance the ecological, social and economic systems of the Maasai pastoralists.

Kimani E, Muhula S, Kiptai T, Orwa J, Odero T, Gachuno O. "Factors influencing TB treatment interruption and treatment outcomes among patients in Kiambu County, 2016-2019." PLoS One. 2021;16(4):e0248820. AbstractWebsite

Tuberculosis (TB) is the leading cause of mortality as a single infectious agent globally with increasing numbers of case notification in developing countries. This study seeks to investigate the clinical and socio-demographic factors of time to TB treatment interruption among Tuberculosis patients in Kiambu County, 2016-2019. We retrospectively analyzed data for all treatment outcomes patients obtained from TB tracing form linked with the Tuberculosis Information Basic Unit (TIBU) of patients in Kiambu County health facilities using time to treatment interruption as the main outcome. Categorical variables were presented using frequency and percentages. Kaplan-Meir curve was used to analyze probabilities of time to treatment interruptions between intensive and continuation phases. Log-rank test statistics was used to compare the equality of the curves. Cox proportion model was used to determine determinants of treatment interruption. A total of 292 participants were included in this study. Males were 68%, with majority (35%) of the participants were aged 24-35 years; 5.8% were aged 0-14 years and 5.1% aged above 55 years. The overall treatment success rate was 66.8% (cured, 34.6%; completed 32.2%), 60.3% were on intensive phase of treatment. Lack of knowledge and relocation were the major reasons of treatment interruptions. Patients on intensive phase were 1.58 times likely to interrupt treatment compared to those on continuation phase (aHR: 1.581; 95%CI: 1.232-2.031). There is need to develop TB interventions that target men and middle aged population in order to reduce treatment interruption and increase the treatment success rates in the County and Country.

Ngayo MO, Oluka M, Bulimo WD, Okalebo FA. Influence of Social Psychological Status On Efavirenz And Nevirapine Plasma Concentration Among HIV Patients In Kenya. Research Square; 2021. Abstract

HIV-related stigma, lack of disclosure and social support are still a hindrance to HIV testing, care, and prevention. We evaluated the influence of these socio-phycological status on nevirapine (NVP) and efavirenz (EFV) plasma concentrations among HIV patients in Kenya. Blood samples were obtained from 254 and 312 consenting HIV patients on NVP and EFV based first-line Antiretroviral therapy (ART) respectively and a detailed structured questionnaire was administered. The NVP and EFV plasma level was measured by liquid chromatography - tandem mass spectrometry (LC-MS/MS). The median duration of living with HIV infection was 5 years (IQR = 1–11years) and a median duration since ART initiation was 3 years (IQR = 1–8 years). There were 68.1% and 65.4% of the patients on NVP and EFV respectively who did not feel guilty for being HIV positive. The disclosure rate was about 96.1% and 94.6% of patients on NVP and EFV respectively. About 85% and 78.2% of patients on NVP and EFV respectively who got social support as much as needed. The non-adherence to ART in the past 30 days was 64.6% and 66.3% patients on NVP and EFV respectively. The median (IQR) plasma concentration were [6237.5 ng/mL, IQR 45188–8964 ng/mL] for NVP and [2739.5 ng/mL, IQR 1878 –4891.5 ng/mL] for EFV. There were 14.2% and 4.5% patients on NVP and EFV respectively with suboptimal plasma concertation associated with poor viral suppression. Multivariate linear regression analysis showed feeling guilty for being HIV positive (adjusted β = 954 , 95% CI = 192.7 to 2156.6 ; p =0.014) or feeling worthless for being HIV positive (adjusted β = 852 , 95% CI = 64.3 to 1639.7 ; p =0.034); being certain of telling the primary sexual partner about HIV positive status (adjusted β 363, 95% CI, 97.9 to 628.1; p = 0.007); disclosing HIV status to neighbors (adjusted β = 1731 , 95% CI = 376 to 3086 ; p =0.012) and getting transportation to hospital whenever needed (adjusted β = -1143.3, 95% CI = -1914.3 to -372.4 ; p =0.004) were associated with NVP/EFV plasma levels. The NVP and EFV plasma level was highly heterogenous with a significant proportion of patients reporting levels correlated with poor viral suppression. The patient’s stigma, lack of disclosure and social support contributes significantly on the overall ART treatment outcome. Taking these factors into consideration, HIV treatment may be personalized to achieve optimal treatment success

Nyabongo L, Odongo DO, Milton G, Machuka E, Vudriko P, Pelle R, Kanduma EG. "Molecular survey of cattle ticks in Burundi: First report on the presence of the invasive Rhipicephalus microplus tick." PLoS One. 2021;16(12):e0261218. Abstract

A recent research study on prevalence of tick-borne pathogens in Burundi reported high prevalence and endemicity of Theileria parva, Anaplasma marginale and Babesia bigemina infections in cattle. Detailed information about tick species infesting animals, their distribution and genetic diversity in Burundi is outdated and limited. This study therefore assessed the prevalence and genetic diversity of tick species infesting cattle across agroecological zones (AEZs) in Burundi. A cross-sectional study on the occurrence of tick species was conducted in 24 districts of Burundi between October and December 2017. Differential identification and characterization of ticks collected was conducted using tick morphological keys and molecular tools (cox1 and 12S rRNA gene). Chi-square test was used to test for association between agroecological zones and the prevalence of tick species. Phylogenetic relationships were inferred using bayesian and maximum likelihood algorithms. A total of 483 ticks were collected from the five AEZs sampled. Six tick species comprising of Rhipicephalus appendiculatus, R. sanguineus, R. evertsi evertsi, R. microplus, R. decoloratus and Amblyomma variegatum were observed. Rhipicephalus appendiculatus were the most prevalent ticks (~45%). A total of 138 specimens (28%) were found to be Rhipicephalus microplus, suggesting an emerging threat for cattle farmers. Twelve R. appendiculatus cox1 haplotypes were obtained from 106 specimens that were sequenced. Two cox1 haplotypes of R. microplus which clustered into previously reported Clade A were observed. Rhipicephalus sanguineus and R. evertsi evertsi ticks, the vectors of numerous zoonotic pathogens, were collected from cattle, which constitute a high risk for public health. These findings reveal an overlapping distribution of tick vectors in Burundi. The design of ticks and tick-borne diseases control strategies should consider the distribution of different vectors across the AEZs particularly the presence of the highly invasive R. microplus tick in Burundi and the potential risk of introducing the pathogenic Babesia bovis.

Peter SG, Kariuki HW, Aboge GO, Gakuya DW, Maingi N, Mulei CM. "Prevalence of Ticks Infesting Dairy Cattle and the Pathogens They Harbour in Smallholder Farms in Peri-Urban Areas of Nairobi, Kenya." Veterinary Medicine International. 2021;2021:9501648. AbstractWebsite

This study aimed at determining the tick species infesting dairy cattle in Nairobi, Kenya, and the pathogens they harbour. While ticks are well-known vectors of major bacterial pathogens of both veterinary importance and public health importance, few studies have investigated the range of the tick species and the associated pathogens, especially present in unique dairy production systems, which compromise animal welfare, such as those in peri-urban areas. A cross-sectional study was undertaken involving 314 randomly selected dairy cattle in 109 smallholder farms. Each animal was examined for attached ticks followed by morphological tick identification at the species level. Genomic DNA was extracted from each of the ticks, and 16S rDNA gene was amplified for pathogen identification. Sequencing of the amplicons and subsequent BLASTn analysis, multiple sequence alignment, and phylogenetic reconstruction were performed to confirm the species of the pathogens. Sixty-six (21.0%) of the cattle examined had ticks. A total of 94 adult ticks were found on the cattle, and of these, 63 (67.0%), 18 (19.1%), and 13 (13.8%) were in the genera Rhipicephalus, Amblyomma, and Hyalomma, respectively. Twelve tick species in Rhipicephalus genus and two in Amblyomma and Hyalomma genera were identified. Although Rh. decoloratus was the most prevalent tick (24.5% (23/94)), the emerging Rh. microplus (6.4% (6/94)) was also identified. The DNA of Rickettsia was detected in the ticks, with Rickettsia conorii in H. rufipes and A. variegatum, and Rickettsia aeschlimannii in Rh. microplus and H. rufipes, while Ehrlichia ruminantium and E. canis were in A. variegatum. In conclusion, the study reported a wide range of tick species present in the study area including Rhipicephalus microplus, which is an emerging tick species in parts of Kenya. The ticks harboured DNA of Rickettsia and Ehrlichia, highlighting possible animal and human health concerns. Hence, effective tick control strategies remain paramount to prevent potential diseases associated with the harboured pathogens.

Vogel JP, Comrie-Thomson L, Pingray V, Gadama L, Galadanci H, Goudar S, Rose Laisser, Lavender T, Lissauer D, Misra S, Pujar Y, Qureshi ZP, Amole T, Berrueta M, Dankishiya F, Gwako G, Homer CSE, Jobanputra J, Meja S, Nigri C, Mohaptra V, Osoti A, Roberti J, Solomon D, Suleiman M, Robbers G, Sutherland S, Vernekar S, Althabe F, Bonet M, Oladapo OT. "Usability, acceptability, and feasibility of the World Health Organization Labour Care Guide: A mixed-methods, multicountry evaluation." Birth. 2021;48(1):66-75. Abstract

The World Health Organization's (WHO) Labour Care Guide (LCG) is a "next-generation" partograph based on WHO's latest intrapartum care recommendations. It aims to optimize clinical care provided to women and their experience of care. We evaluated the LCG's usability, feasibility, and acceptability among maternity care practitioners in clinical settings.

Gwako GN, Were F, Obimbo MM, John Kinuthia, James N Kiarie, Gachuno OW, Gichangi PB. "Association between utilization and quality of antenatal care with stillbirths in four tertiary hospitals in a low-income urban setting." Acta Obstet Gynecol Scand. 2021;100(4):676-683. Abstract

About 2.6 million stillbirths per year occur globally with 98% occurring in low- and middle-income countries including Kenya, where an estimated 35 000 stillbirths occur annually. Most studies have focused on the direct causes of stillbirth. The aim of this study was to determine the association between antenatal care utilization and quality with stillbirth in a Kenyan set up. This information is key when planning strategies to reduce the stillbirth burden.

Burton MJ, Ramke J, Marques AP, Bourne RRA, Congdon N, Jones I, Ah Tong BAM, Arunga S, Bachani D, Bascaran C, Bastawrous A, Blanchet K, Braithwaite T, Buchan JC, Cairns J, Cama A, Chagunda M, Chuluunkhuu C, Cooper A, Crofts-Lawrence J, Dean WH, Denniston AK, Ehrlich JR, Emerson PM, Evans JR, Frick KD, Friedman DS, Furtado JM, Gichangi MM, Gichuhi S, Gilbert SS, Gurung R, Habtamu E, Holland P, Jonas JB, Keane PA, Keay L, Khanna RC, Khaw PT, Kuper H, Kyari F, Lansingh VC, Mactaggart I, Mafwiri MM, Mathenge W, McCormick I, Morjaria P, Mowatt L, Muirhead D, Murthy GVS, Mwangi N, Patel DB, Peto T, Qureshi BM, Salomão SR, Sarah V, Shilio BR, Solomon AW, Swenor BK, Taylor HR, Wang N, Webson A, West SK, Wong TY, Wormald R, Yasmin S, Yusufu M, Silva JC, Resnikoff S, Ravilla T, Gilbert CE, Foster A, Faal HB. "The Lancet Global Health Commission on Global Eye Health: vision beyond 2020." Lancet Glob Health. 2021;9(4):e489-e551.Website
Mitchell EJ, Pallotti P, Qureshi ZP, Daniels JP, Oliver M, Were F, Osoti A, Gwako G, Kimani V, Opira J, Ojha S. "Parents, healthcare professionals and other stakeholders' experiences of caring for babies born too soon in a low-resource setting: a qualitative study of essential newborn care for preterm infants in Kenya." BMJ Open. 2021;11(6):e043802. Abstract

Prematurity is the leading cause of global neonatal and infant mortality. Many babies could survive by the provision of essential newborn care. This qualitative study was conducted in order to understand, from a family and professional perspective, the barriers and facilitators to essential newborn care. The study will inform the development of an early warning score for preterm and low birthweight infants in low and middle income countries (LMICs).

Oreskovic A, Panpradist N, Marangu D, Ngwane WM, Magcaba ZP, Ngcobo S, Ngcobo Z, Horne DJ, Wilson DPK, Shapiro AE, Drain PK, Lutz BR. "Diagnosing Pulmonary Tuberculosis by Using Sequence-Specific Purification of Urine Cell-Free DNA." J Clin Microbiol. 2021;59(8):e0007421. Abstract

Transrenal urine cell-free DNA (cfDNA) is a promising tuberculosis (TB) biomarker, but is challenging to detect because of the short length (<100 bp) and low concentration of TB-specific fragments. We aimed to improve the diagnostic sensitivity of TB urine cfDNA by increasing recovery of short fragments during sample preparation. We developed a highly sensitive sequence-specific purification method that uses hybridization probes immobilized on magnetic beads to capture short TB cfDNA (50 bp) with 91.8% average efficiency. Combined with short-target PCR, the assay limit of detection was ≤5 copies of cfDNA in 10 ml urine. In a clinical cohort study in South Africa, our urine cfDNA assay had 83.7% sensitivity (95% CI: 71.0 to 91.5%) and 100% specificity (95% CI: 86.2 to 100%) for diagnosis of active pulmonary TB when using sputum Xpert MTB/RIF as the reference standard. The detected cfDNA concentration was 0.14 to 2,804 copies/ml (median 14.6 copies/ml) and was inversely correlated with CD4 count and days to culture positivity. Sensitivity was nonsignificantly higher in HIV-positive (88.2%) compared to HIV-negative patients (73.3%), and was not dependent on CD4 count. Sensitivity remained high in sputum smear-negative (76.0%) and urine lipoarabinomannan (LAM)-negative (76.5%) patients. With improved sample preparation, urine cfDNA is a viable biomarker for TB diagnosis. Our assay has the highest reported accuracy of any TB urine cfDNA test to date and has the potential to enable rapid non-sputum-based TB diagnosis across key underserved patient populations.

Brizuela V, Cuesta C, Bartolelli G, Abdosh AA, Abou Malham S, Assarag B, Castro Banegas R, Díaz V, El-Kak F, El Sheikh M, Pérez AM, Souza JP, Bonet M, Abalos E. "Availability of facility resources and services and infection-related maternal outcomes in the WHO Global Maternal Sepsis Study: a cross-sectional study." Lancet Glob Health. 2021;9(9):e1252-e1261. Abstract

Infections are among the leading causes of maternal mortality and morbidity. The Global Maternal Sepsis and Neonatal Initiative, launched in 2016 by WHO and partners, sought to reduce the burden of maternal infections and sepsis and was the basis upon which the Global Maternal Sepsis Study (GLOSS) was implemented in 2017. In this Article, we aimed to describe the availability of facility resources and services and to analyse their association with maternal outcomes.

Baguiya A, Bonet M, Cecatti JG, Brizuela V, Curteanu A, Minkauskiene M, Jayaratne K, Ribeiro-do-Valle CC, Budianu M-A, Souza JP, Kouanda S. "Perinatal outcomes among births to women with infection during pregnancy." Arch Dis Child. 2021;106(10):946-953. Abstract

This study is part of the Global Maternal Sepsis Study (GLOSS). It aimed to estimate neonatal near-miss (NNM) and perinatal death frequency and maternal risk factors among births to women with infection during pregnancy in low-income and middle-income countries (LMIC).

Baguiya A, Bonet M, Cecatti JG, Brizuela V, Curteanu A, Minkauskiene M, Jayaratne K, Ribeiro-do-Valle CC, Budianu M-A, Souza JP, Kouanda S. "Perinatal outcomes among births to women with infection during pregnancy." Arch Dis Child. 2021;106(10):946-953. Abstract

This study is part of the Global Maternal Sepsis Study (GLOSS). It aimed to estimate neonatal near-miss (NNM) and perinatal death frequency and maternal risk factors among births to women with infection during pregnancy in low-income and middle-income countries (LMIC).

Yang X, He Z, Zheng Y, Wang N, Mulinge M, Schmit J-C, Steinmetz A, Seguin-Devaux C. "Chemical Constituents of and Their Anti-HIV-1 Activity." Molecules. 2021;26(9). Abstract

Three new (-) and 25 known compounds were isolated from the crude extract of . The chemical structures of new compounds were established by extensive spectroscopic analyses including 1D and 2D NMR and HRESIMS. Cassiabrevone () is the first heterodimer of guibourtinidol and planchol A. Compound was a new chalcane, while was a new naphthalene. Cassiabrevone (), guibourtinidol-(4α→8)-epiafzelechin (), taxifolin (), oleanolic acid (), piceatannol (), and palmitic acid (), exhibited potent anti-HIV-1 activity with IC values of 11.89 µM, 15.39 µM, 49.04 µM, 7.95 µM, 3.58 µM, and 15.97 µM, respectively.

Gwako GN, Obimbo MM, Gichangi PB, John Kinuthia, James N Kiarie, Gachuno OW, Were F. "Association between obstetric and medical risk factors and stillbirths in a low-income urban setting." Int J Gynaecol Obstet. 2021;154(2):331-336. Abstract

To evaluate the association between obstetric and medical risk factors and stillbirths in a Kenyan set-up.

Miruka SA, Aboge GO, Macharia RW, George O Obiero, Omwenga IM. "Beta hemolysin gene of Staphylococcus phage 3AJ_2017 genome is a suitable molecular marker for identification and characterization of pathogenic Staphylococcus aureus." Vet Med Sci. 2021. Abstract

Staphylococcus aureus cause diseases both in humans and animals. These diseases range from mild to fatal infections thus necessitating development of a specific molecular method for detection of pathogenic S. aureus.

Vogel JP, Vannevel V, Robbers G, Gwako G, Lavin T, Adanikin A, Hlongwane T, Pattinson RC, Qureshi ZP, Oladapo OT. "Prevalence of abnormal umbilical arterial flow on Doppler ultrasound in low-risk and unselected pregnant women: a systematic review." Reprod Health. 2021;18(1):38. Abstract

While Doppler ultrasound screening is beneficial for women with high-risk pregnancies, there is insufficient evidence on its benefits and harms in low- and unselected-risk pregnancies. This may be related to fewer events of abnormal Doppler flow, however the prevalence of absent or reversed end diastolic flow (AEDF or REDF) in such women is unknown. In this systematic review, we aimed to synthesise available data on the prevalence of AEDF or REDF.

Gogri PY, Bore MC, Rips AGT, Reddy JC, Rostov AT, Vaddavalli PK. "Femtosecond laser-assisted big bubble for deep anterior lamellar keratoplasty." J Cataract Refract Surg. 2021;47(1):106-110. Abstract

To assess the utility of a femtosecond laser-assisted stromal channel to assist the creation of a big bubble (BB) for deep anterior lamellar keratoplasty (DALK) surgery in cadaveric corneas.

Nyabongo L, Kanduma EG, Bishop RP, Machuka E, Njeri A, Bimenyimana AV, Nkundwanayo C, Odongo DO, Pelle R. "Prevalence of tick-transmitted pathogens in cattle reveals that Theileria parva, Babesia bigemina and Anaplasma marginale are endemic in Burundi." Parasit Vectors. 2021;14(1):6. Abstract

Tick-borne diseases (TBDs) constitute a major constraint for livestock development in sub-Saharan Africa, with East Coast fever (ECF) being the most devastating TBD of cattle. However, in Burundi, detailed information is lacking on the current prevalence of TBDs and on the associated economic losses from mortality and morbidity in cattle as well as the costs associated with TBD control and treatment. The aim of this study was, therefore, to assess the prevalence and spatial distribution of tick-borne pathogens (TBPs) in cattle across the major agro-ecological zones (AEZs) in Burundi.

Theunissen F, Cleps I, Goudar S, QURESHI ZAHIDA, Owa OO, Mugerwa K, Piaggio G, Gülmezoglu MA, Nakalembe M, Byamugisha J, Osoti A, Mandeep S, Poriot T, Gwako G, Vernekar S, Widmer M. "Cost of hospital care of women with postpartum haemorrhage in India, Kenya, Nigeria and Uganda: a financial case for improved prevention." Reprod Health. 2021;18(1):18. Abstract

Access to quality, effective lifesaving uterotonics in low and middle-income countries (LMICs) remains a major barrier to reducing maternal deaths from postpartum haemorrhage (PPH). Our objective was to assess the costs of care for women who receive different preventative uterotonics, and with PPH and no-PPH so that the differences, if significant, can inform better resource allocation for maternal health care.

Mwangi KW, Macharia RW, Bargul JL. "Gene co-expression network analysis of Trypanosoma brucei in tsetse fly vector." Parasit Vectors. 2021;14(1):74. Abstract

Trypanosoma brucei species are motile protozoan parasites that are cyclically transmitted by tsetse fly (genus Glossina) causing human sleeping sickness and nagana in livestock in sub-Saharan Africa. African trypanosomes display digenetic life cycle stages in the tsetse fly vector and in their mammalian host. Experimental work on insect-stage trypanosomes is challenging because of the difficulty in setting up successful in vitro cultures. Therefore, there is limited knowledge on the trypanosome biology during its development in the tsetse fly. Consequently, this limits the development of new strategies for blocking parasite transmission in the tsetse fly.

Dean WH, Buchan J, Gichuhi S, Philippin H, Arunga S, Mukome A, Admassu F, Lewis K, Makupa W, Otiti J, Kim MJ, Macleod D, Cook C, Burton MJ. "Simulation-based surgical education for glaucoma versus conventional training alone: the GLAucoma Simulated Surgery (GLASS) trial. A randomised controlled, educational intervention efficacy trial in Kenya, South Africa, Tanzania, Uganda and Zimbabwe." Br J Ophthalmol. 2021. AbstractWebsite

Background/aim: Glaucoma accounts for 8% of global blindness and surgery remains an important treatment. We aimed to determine the impact of adding simulation-based surgical education for glaucoma.

Methods: We designed a randomised controlled, parallel-group trial. Those assessing outcomes were masked to group assignment. Fifty-one trainee ophthalmologists from six university training institutions in sub-Saharan Africa were enrolled by inclusion criteria of having performed no surgical trabeculectomies and were randomised. Those randomised to the control group received no placebo intervention, but received the training intervention after the initial 12-month follow-up period. The intervention was an intense simulation-based surgical training course over 1 week. The primary outcome measure was overall simulation surgical competency at 3 months.

Results: Twenty-five were assigned to the intervention group and 26 to the control group, with 2 dropouts from the intervention group. Forty-nine were included in the final intention-to-treat analysis. Surgical competence at baseline was comparable between the arms. This increased to 30.4 (76.1%) and 9.8 (24.4%) for the intervention and the control group, respectively, 3 months after the training intervention for the intervention group, a difference of 20.6 points (95% CI 18.3 to 22.9, p<0.001). At 1 year, the mean surgical competency score of the intervention arm participants was 28.6 (71.5%), compared with 11.6 (29.0%) for the control (difference 17.0, 95% CI 14.8 to 19.4, p<0.001).

Conclusion: These results support the pursuit of financial, advocacy and research investments to establish simulation surgery training units and courses including instruction, feedback, deliberate practice and reflection with outcome measurement to enable trainee glaucoma surgeons to engage in intense simulation training for glaucoma surgery.

Trial registration number: PACTR201803002159198.

Lubembe DM, Odongo DO, Joubert F, Sibeko-Matjila KP. "Limited diversity in the CD8+ antigen-coding loci in Theileria parva parasites from cattle from southern and eastern Africa." Vet Parasitol. 2021;291:109371. Abstract

Theileria parva infections in cattle causes huge economic losses in the affected African countries, directly impacting the livelihood of the poor small-holder farmers. The current immunization protocol using live sporozoites in eastern Africa, is among the control measures designed to limit T. parva infections in cattle. However, the ability of the immune protection induced by this immunization to protect against field parasites has been compromised by the diversity of the parasite involving the schizont antigen genes. Previous studies have reported on the antigenic diversity of T. parva parasites from southern and eastern Africa, however, similar reports on T. parva parasites particularly from cattle from southern Africa remains scanty, due to the self-limiting nature of Corridor disease. Thus, we evaluated the diversity of CD8+ T-cell regions of ten schizont antigen genes in T. parva parasites associated with Corridor disease and East Coast fever (ECF) from southern and eastern Africa respectively. Regions of schizont antigen (TpAg) genes containing the CD8+ T-cell epitopes (CTL determinants) were amplified from genomic DNA extracted from blood of T. parva positive samples, cloned and sequenced. The results revealed limited diversity between the two parasite groups from cattle from southern and eastern Africa, defying the widely accepted notion that antigen-encoding loci in cattle-derived parasites are conserved, while in buffalo-derived parasites, they are extensively variable. This suggests that only a sub-population of parasites is successfully transmitted from buffalo to cattle, resulting in the limited antigenic diversity in Corridor disease parasites. Tp4, Tp5, Tp7 and Tp8 showed limited to absence of diversity in both parasite groups, suggesting the need to further investigate their immunogenic properties for consideration as candidates for a subunit vaccine. Distinct and common variants of Tp2 were detected among the ECF parasites from eastern Africa indicating evidence of parasite mixing following immunization. This study provides additional information on the comparative diversity of TpAg genes in buffalo- and cattle-derived T. parva parasites from cattle from southern and eastern Africa.

Theunissen F, Cleps I, Goudar S, QURESHI ZAHIDA, Owa OO, Mugerwa K, Piaggio G, Gülmezoglu MA, Nakalembe M, Byamugisha J, Osoti A, Mandeep S, Poriot T, Gwako G, Vernekar S, Widmer M. "Correction to: Cost of hospital care of women with postpartum haemorrhage in India, Kenya, Nigeria and Uganda: a financial case for improved prevention." Reprod Health. 2021;18(1):57.
Tanyi WN, Gachuno O, Odero T, Farquhar C, Kimosop D, Mayi A. "Factors affecting adherence to antiretroviral therapy among children and adolescents living with HIV in the Mbita Sub-County Hospital, Homa Bay- Kenya." Afr Health Sci. 2021;21(Suppl):18-24. AbstractWebsite

Adequate adherence to antiretroviral therapy (ART) is key to the successful treatment of children and adolescents living with HIV. Continuous ART Adherence is the key factor for virologic suppression and stability of the immune system and prevents the occurrence of opportunistic infections. Children and adolescents struggle with adherence to ART for various reasons, including a poor psychosocial support system and clinic attendance.

Zheng Y, Yang X-W, Schols D, Mori M, Botta B, Chevigné A, Mulinge M, Steinmetz A, Schmit J-C, Seguin-Devaux C. "Active Components from Prevent HIV-1 Entry by Distinct Mechanisms of Action." Int J Mol Sci. 2021;22(9). Abstract

is widely used in Sub-Saharan Africa for treating many diseases, including HIV-1 infection. We have recently described the chemical structures of 28 compounds isolated from an alcoholic crude extract of barks and roots of , and showed that six bioactive compounds inhibit HIV-1 infection. In the present study, we demonstrate that the six compounds block HIV-1 entry into cells: oleanolic acid, palmitic acid, taxifolin, piceatannol, guibourtinidol-(4α→8)-epiafzelechin, and a novel compound named as cassiabrevone. We report, for the first time, that guibourtinidol-(4α→8)-epiafzelechin and cassiabrevone inhibit HIV-1 entry (IC of 42.47 µM and 30.96 µM, respectively), as well as that piceatannol interacts with cellular membranes. Piceatannol inhibits HIV-1 infection in a dual-chamber assay mimicking the female genital tract, as well as HSV infection, emphasizing its potential as a microbicide. Structure-activity relationships (SAR) showed that pharmacophoric groups of piceatannol are strictly required to inhibit HIV-1 entry. By a ligand-based in silico study, we speculated that piceatannol and norartocarpetin may have a very similar mechanism of action and efficacy because of the highly comparable pharmacophoric and 3D space, while guibourtinidol-(4α→8)-epiafzelechin and cassiabrevone may display a different mechanism. We finally show that cassiabrevone plays a major role of the crude extract of by blocking the binding activity of HIV-1 gp120 and CD4.

Scriven YA, Mulinge MM, Saleri N, Luvai EA, Nyachieo A, Maina EN, Mwau M. "Prevalence and factors associated with HIV-1 drug resistance mutations in treatment-experienced patients in Nairobi, Kenya: A cross-sectional study." Medicine (Baltimore). 2021;100(40):e27460. Abstract

An estimated 1.5 million Kenyans are HIV-seropositive, with 1.1 million on antiretroviral therapy (ART), with the majority of them unaware of their drug resistance status. In this study, we assessed the prevalence of drug resistance to nucleoside reverse transcriptase inhibitors (NRTIs), nucleoside reverse transcriptase inhibitors (NNRTIs), and protease inhibitors, and the variables associated with drug resistance in patients failing treatment in Nairobi, Kenya.This cross-sectional study utilized 128 HIV-positive plasma samples obtained from patients enrolled for routine viral monitoring in Nairobi clinics between 2015 and 2017. The primary outcome was human immunodeficiency virus type 1 (HIV-1) drug resistance mutation counts determined by Sanger sequencing of the polymerase (pol) gene followed by interpretation using Stanford's HIV Drug Resistance Database. Poisson regression was used to determine the effects of sex, viral load, age, HIV-subtype, treatment duration, and ART-regimen on the primary outcome.HIV-1 drug resistance mutations were found in 82.3% of the subjects, with 15.3% of subjects having triple-class ART resistance and 45.2% having dual-class resistance. NRTI primary mutations M184 V/I and K65R/E/N were found in 28.8% and 8.9% of subjects respectively, while NNRTI primary mutations K103N/S, G190A, and Y181C were found in 21.0%, 14.6%, and 10.9% of subjects. We found statistically significant evidence (P = .013) that the association between treatment duration and drug resistance mutations differed by sex. An increase of one natural-log transformed viral load unit was associated with 11% increase in drug resistance mutation counts (incidence rate ratio [IRR] 1.11; 95% CI 1.06-1.16; P < .001) after adjusting for age, HIV-1 subtype, and the sex-treatment duration interaction. Subjects who had been on treatment for 31 to 60 months had 63% higher resistance mutation counts (IRR 1.63; 95% CI 1.12-2.43; P = .013) compared to the reference group (<30 months). Similarly, patients on ART for 61 to 90 months were associated with 133% higher mutation counts than the reference group (IRR 2.33; 95% CI 1.59-3.49; P < .001). HIV-1 subtype, age, or ART-regimen were not associated with resistance mutation counts.Drug resistance mutations were found in alarmingly high numbers, and they were associated with viral load and treatment time. This finding emphasizes the importance of targeted resistance monitoring as a tool for addressing the problem.

Ogana W, Juma VO, Bulimo WD. "A SIRD model applied to COVID-19 dynamics and intervention strategies during the first wave in Kenya." medRxiv. 2021:2021.03.17.21253626. AbstractWebsite

The first case of COVID-19 was reported in Kenya in March 2020 and soon after non-pharmaceutical interventions (NPIs) were established to control the spread of the disease. The NPIs consisted, and continue to consist, of mitigation measures followed by a period of relaxation of some of the measures. In this paper, we use a deterministic mathematical model to analyze the dynamics of the disease, during the first wave, and relate it to the intervention measures. In the process, we develop a new method for estimating the disease parameters. Our solutions yield a basic reproduction number, R0 = 2.76, which is consistent with other solutions. The results further show that the initial mitigation reduced disease transmission by 40% while the subsequent relaxation increased transmission by 25%. We also propose a mathematical model on how interventions of known magnitudes collectively affect disease transmission rates. The modelled positivity rate curve compares well with observations. If interventions of unknown magnitudes have occurred, and data is available on the positivity rate, we use the method of planar envelopes around a curve to deduce the modelled positivity rate and the magnitudes of the interventions. Our solutions deduce mitigation and relaxation effects of 42.5% and 26%, respectively; these percentages are close to values obtained by the solution of the SIRD system. Our methods so far apply to a single wave; there is a need to investigate the possibility of extending them to handle multiple waves.Competing Interest StatementThe authors have declared no competing interest.Clinical TrialNot a clinical trialFunding StatementNo funding supportAuthor DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:KNH-UoN Ethics and Research Committee https://erc.uonbi.ac.keAll necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).YesI have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesData sources: All the data used is in the public domain [1, 44, 56, 57]

Nyumba TO, Sang CC, Olago DO, Marchant R, Waruingi L, Githiora Y, Kago F, Mwangi M, Owira G, Barasa R, Omangi S. "Assessing the ecological impacts of transportation infrastructure development: A reconnaissance study of the Standard Gauge Railway in Kenya." PLOS ONE. 2021;16(1):e0246248-. AbstractWebsite

Transportation infrastructure, such as railways, roads and power lines, contribute to national and regional economic, social and cultural growth and integration. Kenya, with support from the Chinese government, is currently constructing a standard gauge railway (SGR) to support the country’s Vision 2030 development agenda. Although the actual land area affected by the SGR covers only a small proportion along the SGR corridor, a significant proportion of the area supports a wide range of ecologically fragile and important ecosystems in the country, with potential wider impacts. This study used a qualitative content analysis approach to gain an understanding and perceptions of stakeholders on the potential ecological impacts of the interactions between the SGR and the traversed ecological systems in Kenya. Three dominant themes emerged: 1) ecosystem degradation; 2) ecosystem fragmentation; and 3) ecosystem destruction. Ecosystem degradation was the most commonly cited impact at while ecosystem destruction was of the least concern and largely restricted to the physical SGR construction whereas the degradation and fragmentation have a much wider footprint. The construction and operation of the SGR degraded, fragmented and destroyed key ecosystems in the country including water towers, protected areas, community conservancies and wildlife dispersal areas. Therefore, we recommend that project proponents develop sustainable and ecologically sensitive measures to mitigate the key ecosystem impacts.

Umuhoza T, Bulimo WD, Julius Oyugi, Musabyimana JP, Kinengyere AA, Mancuso JD. "Prevalence of human respiratory syncytial virus, parainfluenza and adenoviruses in East Africa Community partner states of Kenya, Tanzania, and Uganda: A systematic review and meta-analysis (2007–2020)." PLOS ONE. 2021;16(4):e0249992-. Abstractjournal.pone_.0249992.pdfjournal.pone_.0249992.pdfWebsite

Background Viruses are responsible for a large proportion of acute respiratory tract infections (ARTIs). Human influenza, parainfluenza, respiratory-syncytial-virus, and adenoviruses are among the leading cause of ARTIs. Epidemiological evidence of those respiratory viruses is limited in the East Africa Community (EAC) region. This review sought to identify the prevalence of respiratory syncytial virus, parainfluenza, and adenoviruses among cases of ARTI in the EAC from 2007 to 2020. Methods A literature search was conducted in Medline, Global Index Medicus, and the grey literature from public health institutions and programs in the EAC. Two independent reviewers performed data extraction. We used a random effects model to pool the prevalence estimate across studies. We assessed heterogeneity with the I2 statistic, and Cochran’s Q test, and further we did subgroup analysis. This review was registered with PROSPERO under registration number CRD42018110186. Results A total of 12 studies met the eligibility criteria for the studies documented from 2007 to 2020. The overall pooled prevalence of adenoviruses was 13% (95% confidence interval [CI]: 6–21, N = 28829), respiratory syncytial virus 11% (95% CI: 7–15, N = 22627), and parainfluenza was 9% (95% CI: 7–11, N = 28363). Pooled prevalence of reported ARTIs, all ages, and locality varied in the included studies. Studies among participants with severe acute respiratory disease had a higher pooled prevalence of all the three viruses. Considerable heterogeneity was noted overall and in subgroup analysis. Conclusion Our findings indicate that human adenoviruses, respiratory syncytial virus and parainfluenza virus are prevalent in Kenya, Tanzania, and Uganda. These three respiratory viruses contribute substantially to ARTIs in the EAC, particularly among those with severe disease and those aged five and above.

Matara SM, Siriba DN, Kiema JB, Musyoka SM. "Predicting Displacement Effects of Tectonic Movements on the Kenyan Geodetic Reference Frame Network (KENREF) .". In: Working eWeek. Netherlands; 2021.
Mutembei PH. "Insights of Sustainable Livestock Production.". In: KCSAP 2021. Naivasha Resort; 2021.
Ralwala AO. "Honouring National Heroes through Architecture: a case of the Presidential Mausoleum. .". In: Modern Heritage (in the Anthropocene) in collaboration with University of Cape Town; UNESCO; UNESCO World Heritage Centre; African World Heritage Fund; UCL Bartlett School of Architecture; PAMOA; ICCROM; ICOMOS & IUCN. the Cape Town Conference on ‘Modern Heritages of Africa’ 22-24 September ; 2021.
• Matara SM, • Siriba DN, • Kiema JBK, • Musyoka SM. "Predicting Displacement Effects of Tectonic Movements on the Kenyan Geodetic Reference Frame Network (KENREF).". In: FIG e-Working Week 2021. Netherlands; 2021.
Akinyi J, Mwaniki A, Gichamba A, Kariuki D, Chand P, Munene S, Nyakinyua C, Nzangi B, Akinyi V, Betsy M, Cosmas K, Mwangi M. "NanoSatellite Platform for the University of Nairobi (NaSPUoN) Student Project.". In: 72nd International Astronautical Congress (IAC). Dubai, United Arab Emirates (presented online); 2021.
Geno KPO, Ralwala AO. "Assessment of Heat Stress Exposure on Construction Workers in Hot and Humid Environments during the Covid-19 Pandemic Period.". In: (Re)Setting Built Environment Theory and Practice in a Post-pandemic World: Disrupted Buildings or Design for Disruption. School of Architecture and Building Sciences (SABS) online (virtual) conference, JKUAT; 2021.
Koteng POG, Ralwala AO. "Assessment of Heat Stress Exposure on Construction Workers in Hot and Humid Environments during the Covid-19 Pandemic Period. .". In: (Re)Setting Built Environment Theory and Practice in a Post-pandemic World: Disrupted Buildings or Design for Disruption. School of Architecture and Building Sciences (SABS) online (virtual) conference, JKUAT; 2021.
Chikwana N, Maina EN, Gavamukulya Y, Bulimo W, Wamunyokoli F. "Antiproliferative Activity, c-Myc and {FGFR}1 Genes Expression Profiles and Safety of Annona muricata Fruit Extract on Rhabdomyosarcoma and {BALB}/c Mice." Journal of Complementary and Alternative Medical Research. 2021:30-46. AbstractWebsite
n/a
Faris AA, Akuon PO, Kalecha VO. "BER Performance of SSK Sequence Modulation.". In: IEEE AFRICON 2021. Arusha, Tanzania; 2021.
2022
Omweri LG, Okaru AO, Abuga KO, Ndwigah SN. "Quality of povidone-iodine and chlorhexidine-based oral care products in Nairobi, Kenya." F1000Research. 2022;11:343. Abstract
n/a
J O’o, J M, I O, T A. "Anatomical Variations of the Fifth Lumbar Artery in a sample Kenyan population." Ann Afr surg. 2022;19(2):100-107. AbstractWebsite

bstract
Background: Anatomical variations of lumbar arteries predispose them to iatrogenic injury during endovascular intervention or surgery. Due to limited morphological data on lumbar arteries in our setting, we aimed to determine their variant anatomy among Kenyans.

Methods: We performed the study on 90 cadaveric specimens and 120 computed tomography (CT) scans. Cadavers were dissected to expose the aorta and the lumbar arteries emerging from them. The number, origins, location relative to the vertebral bodies, and relations to aortic bifurcation were determined in cadavers and CT scans. Data were analyzed using SPSS (version 21.0).

Results: On average, 3 (3/90 [3.3%]), 4 (63/90 [70%]) or 5 (24/90 [26.7%]) pairs of lumbar arteries were observed among the cadaveric specimens, whereas 4 (100/120 [83.3%]) or 5 (20/120 [16.7%]) pairs were observed in CTs. Differences in the number of pairs observed in the cadaveric versus CT study were not statistically significant (P = .542). There were no sex differences in the number of lumbar artery pairs observed in CT scans (P = .178). The first 3 lumbar artery pairs had a single-origin, whereas the fourth lumbar artery had a common-stem origin. The first, second, and third lumbar arteries mostly originated at the upper third of their respective vertebral bodies. The fourth lumbar artery predominantly originated at the lower third.

Conclusion: Our study's findings show unique variation in the lumbar arteries' relation to the vertebral bodies and the distances between artery pairs.

Level of evidence: IV (cross-sectional study).

Clinical relevance: Variations in the anatomy of the lumbar arteries should be taken into consideration, especially in surgical or interventional procedures to avoid inadvertent injury of the vessels.

Nguli M, Gatari MJ, Keith Shepherd, Njenga L, Boman J. "Assessment of Essential Micronutrient Levels in Common Beans (Phaseolus vulgaris) in Kenya by Total reflection X-ray Fluorescence (TXRF)." X-Ray Spectrometry. 2022;2022. Abstract

This study reports concentrations of Mn, Fe, Cu and Zn analysed from Kenyan bean grains and leaves using Total Reflection X-ray Fluorescence (TXRF) and Inductively Coupled Plasma – Optical Emission Spectrometry (ICP-OES) methods. Samples of fresh bean leaves and 7 species of dry grains were collected from small scale farmers in Machakos and Kiambu counties. They were delivered to the laboratory where bean grain samples for TXRF analysis were prepared and leaves for both TXRF and ICP-OES. Standard methods of sample preparation successfully tested and used by other authors were used, Average elemental concentrations of the samples were then compared with established sufficiency values mainly given in ranges. Bean leaves from Muguga had sufficient Mn, Ni and Cu concentrations while 6% of the samples had Zn concentrations higher than the sufficiency range. Fe concentrations were consistently high with 97% of the samples having concentrations that were higher than the sufficiency range. No deficiencies were observed from bean leaves from Kyevaluki. For dry bean grains, deficiencies were observed in which four species were found to be deficient in Mn while Zn deficiency was observed in all the species. Fe concentrations were above the sufficiency ranges for all the species but not to toxic levels and 29% of the samples had Cu concentrations that were within the sufficiency range. The obtained data will be essential information for both farmers and policy makers on the nutritional quality of beans in the sampled areas. However, further studies are recommended including soil analysis and elemental bioavailability for full nutritional assessment. Keywords: ICP-OES, hidden hunger, mortality rate, cognitive development, bioavailable

PN R, GO O, O AE, L A, J K. "Assessment of Guideline Concordant Antibiotic Prescribing for Patients with Community Acquired Pneumonia at The Kenyatta National Hospital Medical Wards." Journal of Kenya Association of Physicians. 2022;5(1):34-42. Abstractassessment_of_guideline_concordant_antibiotic_prescribing.pdf

Background: Pneumonia is a major cause of morbidity
and mortality globally. Despite the proven benefits of
guideline concordant antibiotic prescribing, research
has shown that adherence to clinical guideline
recommendations is dismal.
Objectives: The study aims to determine utilization of
Kenyatta National Hospital antibiotic guideline titled
‘The KNH guide to empiric antimicrobial therapy
2018’ in the management of community acquired
pneumonia in the Kenyatta National Hospital medical
wards and the perceived barriers towards the utilization
of this guideline.
Materials and methods: A check list derived from the
Kenyatta National Hospital (KNH) guide to empiric
antimicrobial therapy 2018 was used to assess guideline
concordance based on seven quality indicators:
empiric antibiotic, dose and route of administration,
switch to oral antibiotics, duration of antibiotics (at
least 5 days), collection of microbiological samples
before initiating antibiotics, review of antibiotics at 48
hours and once the culture results are out. Online selfadministered questionnaires were used to determine
attitude and perceived barriers towards utilization
of the KNH guideline among the Internal Medicine
registrars and medical officers.
Analysis: Descriptive statistics were applied in
the representation of each of the seven quality
indicators. These were then compared with the
guideline recommendations and adherence to the
guideline for each parameter was expressed as a
percentage of the total number of patients admitted
with community acquired pneumonia. These were
then graded into the following categories based on the
level of concordance: Good >90%, Intermediate 60-
90%, poor <60%. Questions on the attitude and the
perceived barriers towards KNH guideline utilization
were answered using a 5 point Likert scale. Perceived
barrier statements that were positively formulated
were then recorded so that a lower score meant a
lower level of the perceived barriers and vice versa.
Percentages were then calculated for the total number
of doctors that agreed or strongly agreed that the
barrier was applicable. An open ended question on the
top three barriers to the KNH guideline utilization was
also included in the questionnaire.
Results: For each of the other quality indicators,
adherence to the KNH guideline for patients with
community acquired pneumonia was as follows:
empiric antibiotic choice 48%, collection of samples
for culture prior to antibiotic administration 0%, review
of antibiotics at 48 hours 26.4%, review of antibiotics
with culture results 45.8%, total duration of antibiotics
28.8% and time to switch to oral antibiotics 3.6%. The
top three barriers towards guideline utilization among
the doctors were: unavailability of drugs (52.7%),
inaccessibility of the KNH guideline (45.1%) and lack
of or delay of investigations (34.1%).
Conclusion: This study has demonstrated that the level
of adherence to the seven quality indicators from the
KNH guide is poor with the overall adherence being
35.5%. The recommendation least adhered to was
collection of microbiological samples before initiation
of empiric antibiotics. The most commonly identified
barriers to utilization of the guideline were external
and guideline related barriers.
Key words: Guide to empiric antimicrobial therapy
2018, Guideline Concordance antibiotic prescribing,
Community acquired pneumonia

Wachira SN, Ndwigah SN, Ongarora DSB, Okaru AO. "Assessment of the Quality of Sodium Hypochlorite and Hydrogen Peroxide product samples in Nairobi County." International Journal of Novel Research and Development. 2022;7(3):503-514.
Moturi CA, Wairimu AG. "Big data adoption in official statistics in Kenya: challenges, opportunities and determinants." Statistical Journal of the IAOS . 2022;38(1):251-262. AbstractWebsite

The data revolution has increased data demands for leveraging on Big Data in the production of statistics. The paper assesses the adoption of Big Data in research institutes in Kenya. Data were collected from 64 data practitioners based in the 24 research institutes that have a mandate to produce and analyse official statistics. The paper establishes the risks and challenges of using Big Data in statistics, identifies the determinants of adoption of Big Data in statistics and validates the relevance of a Technology Adoption Model (TAM) for predicting the adoption. It is the conclusion that there are immense opportunities for Big Data in statistics if the associated risks and challenges are addressed and the identified key determinants prioritized to promote the adoption.

Hashim I, Onyari JM, Omosa LK, Maru SM, Nchiozem-Ngnitedem V-A, Karpoormath R. "Conglomeratin: A new antibacterial flavonol derivative from Macaranga conglomerata Brenan (Euphorbiaceae)." Natural Products Research. 2022:https://doi.org/10.1080/14786419.2022.2061481.hashim_et_al_2022_natural_products_research.pdf
Nchiozem-Ngnitedem V-A, Omosa LK, Derese S, Efferth T, Spiteller M. "Cytotoxic flavonoids from the seeds of Dracaena steudneri Engl against leukemia cancer cell lines." Phytomedicine Plus. 2022;2(2):100234.alexe_et_al_2022_phytomedicine_plus.pdf
Hoang NT, Nguyen VT, Tuan NDM, Manh TD, Le P-C, Tac DV, Mwazighe FM. "Degradation of dyes by UV/Persulfate and comparison with other UV-based advanced oxidation processes: Kinetics and role of radicals." Chemosphere. 2022.Website
Wango GM, Esadia, N. "Dog owners report fewer depression symptoms and a greater sense of social support during the pandemic." The Counsel-ling Magazine. 2022;2(1):48-49.
Ali H, Nguta J, Musila F, Ole-Mapenay I, Matara D, Mailu J. "Evaluation of Antimicrobial Activity, Cytotoxicity, and Phytochemical Composition of Ocimum americanum L. (Lamiaceae)." Evidence-Based Complementary and Alternative Medicine. 2022;2022:11.
Wafula, WM, Wasonga OV, Koech OK, Kibet S. "Factors influencing migration and settlement of pastoralists in Nairobi City, Kenya." Pastoralism: Research, Policy and Practice. 2022;12(2).
Wafula WM, Wasonga OV, Koech OK, Kibet S. "Factors influencing migration and settlement of pastoralists in Nairobi City, Kenya." Pastoralism: Research, Policy and Practice. 2022;12(1):1-14.
L. G, A W. "Financing the Future of the WHO ." Lancet. 2022;399(10334):1445-1447.
MW N, GO O, M M, W S. "Frequency of thyroid dysfunction among rheumatoid arthritis patients at the Kenyatta National Hospital, Nairobi, Kenya." afr j Rheumatal. 2022;10(1):34-44. Abstractfrequency_of_thyroid_dysfunction_among_ra_patients_at_knh.pdf

Background: Rheumatoid Arthritis
(RA) affects 0.5-1% of the adult
population. A higher prevalence of
thyroid dysfunction is observed in
patients with RA compared to the
general population.
Objectives: To establish the
frequency of thyroid dysfunction
among ambulatory RA patients and
to describe the association between
thyroid dysfunction and the patients’
socio-demographic characteristics,
clinical characteristics, level of disease
activity, and their functional status.
Design: This was a cross-sectional
descriptive study.
Methods: Adult patients on follow
up for RA at the outpatient clinic were
sampled. Sociodemographic data was
recorded. The Clinical Disease Activity
Index (CDAI) and Health Assessment
Questionnaire (HAQ) scores were
computed from examination findings
and questionnaires respectively. A
venous blood sample was analyzed for
Thyroid-Stimulating Hormone (TSH),
free triidothyronine (fT3), and free
tetraiodothyronine (fT4). This data
was analyzed to determine frequencies
and associations.
Results: Seventy-six patients were
recruited into the study. Sixty-one
participants were female. The mean
TSH level was 5.8Miu/L. The frequency
of thyroid dysfunction was 47.4%.
Overt hypothyroidism was the most
common form of thyroid dysfunction at
39.5% while 6.6% had Sick Euthyroid.
Majority of the participants, 75%, had
low disease activity, mean CDAI was
11.6. Forty-one (53.9%) participants
had no disability, mean HAQ was
0.5. Correlations between thyroid
dysfunction and advancing age,
duration of disease, level of disease
activity, and functional disability did
not attain statistical significance.
Conclusion: Thyroid dysfunction
is common among patients with RA
with no significant association found
between thyroid dysfunction sociodemographic characteristics, clinical
characteristics, level of disease activity,
and functional status.
Key words: Thyroid dysfunction,
Rheumatoid arthritis, Disease activity,
Functional disability
Introduction
Rheumatoid Arthritis (RA) is a
symmetric polyarthritis with a variety
of systemic manifestations. In the
general population thyroid dysfunction
affects 1-10% of adults, with variations
in geographical areas, age and sex1
.
The causes of thyroid dysfunction
include; iodine deficiency, infections
and autoimmune associated thyroid
disease2
. Thyroid dysfunction is more
prevalent in patients with autoimmune
diseases such as RA. This is attributed
to overlap of autoimmune conditions
that are initiated by loss of tolerance to
self-antigens3
.
The burden of thyroid dysfunction
among RA patients has been found
to vary between 6-47% in various
studies. The entire spectrum of thyroid
dysfunction has been described,
however, hypothyroidism occurs
more frequently. Patients with thyroid
dysfunction have higher RA disease
activity scores and poorer functional
status measured using the

Runtuwene LR, Sathirapongsasuti N, Srisawat R, Komalamisra N, Tuda JSB, EMongan A, Aboge GO. "Global research alliance in infectious disease: a collaborative effort to combat infectious diseases through dissemination of portable sequencing." BMC Research Notes . 2022;(2022) 15:44 .
Heng YY, Asad I, Coleman B, Menard L, Benki-Nugent S, Faridah H Were, Karr CJ, McHenry MS. "Heavy metals and neurodevelopment of children in low and middle-income countries: A systematic review." PLOS ONE. 2022;17(3).
Misango, G.V, Nzuma, M.J., Irungu, L.W., Kassie, M. "Intensity of adoption of integrated pest management practices in Rwanda: A fractional logit approach." Heliyon. 2022;https://doi.org/10.1016/j.heliyon.2022.e08735.
Njuru SN, Njogu PM, Mugo HN, Thoithi GN. "Is tablet splitting a potential pitfall in drug therapy? A case study of amlodipine tablets." Pharmaceut. Jour. Kenya. 2022.
Wango GM, Ngerema D, Owang S. "Languishing and Assisting People Get on their Feet." The Counsel-ling Magazine. 2022;2(1):7-9.languishing_and_assisting_people_get_on_their_feet.pdf
Upadhyaya R, Wamalwa H. Learning and capabilities development: Case studies of East African social enterprises. https://www.ikeasocialentrepreneurship.org/en/useful-reads/learning-capabilities-development; 2022.
Johnson L, Onjala J. "Logic of the Belt and Road Initiatives Early Eastern Africa Node: Economic, Demographic and Political Economy Rationales." Journal of Chinese Economic and Foreign Trade Studies,. 2022;accepted January 28 2022.
Mbuge DO, Gumbe LO. "Mechanical Properties of Bamboo (Bambusa Vulgaris)." Journal of Engineering in Agriculture and the Environment . 2022;8-no1.
Su R, Wu J, Hu J, Ma L, Ahmed S, Zhang Y, Abdulraheem MI, Birech Z, Li L, Li C, Wei W. "Minimalizing Non-Point Source Pollution Using a Cooperative Ion Selection Electrode System for Estimating Nitrate Nitrogen in Soil." Frontiers in Plant Science. 2022;12:810214.
Kimani PK´ethe, Mbuge D, Gitau AN. "Properties of Nonwoven Fabrics Containing Immobilized Superabsorbent Polymer Particles for Air Conditioning in Grain Dryers, Applied Engineering in Agriculture." American Society of Agricultural and Biological Engineers. 2022;38(2)(ISSN 0883-8542).
Omweri LG, Okaru AO, Abuga KO, Ndwigah SN. "Quality of povidone-iodine and chlorhexidine-based oral care products in Nairobi, Kenya." F1000Research. 2022;11:343. Abstract

Background: The oral cavity harbors many microbes that may cause diseases, including dental caries and periodontal diseases. Progressive inflammation from periodontal diseases may lead to gum detachment from the teeth. Povidone-iodine and chlorhexidine mouth rinses and gargles are broad-spectrum antimicrobial products that effectively manage dental caries and periodontal diseases and eliminate plaques. This study was conducted in Nairobi County, Kenya to establish the quality of povidone-iodine and chlorhexidine oral care products by determining the content of the active pharmaceutical ingredient and compliance with labeling requirements.
Methods: A total of 34 samples (from 15 brands) of povidone-iodine and 15 samples (from nine brands) of chlorhexidine were collected from retail pharmacies using convenience sampling. All samples were subjected to labeling analysis, identity, and assay tests. Potentiometric titration was used to assay povidone-iodine in the samples, while chlorhexidine was assayed using high-performance liquid chromatography (HPLC) according to British Pharmacopeia 2017 specifications.
Results: All samples complied with identification tests. Moreover, 47.1% of povidone-iodine and 66.7% of chlorhexidine products complied with pharmacopoeial assay specifications. Five povidone-iodine (14.7%) and four chlorhexidine (26.7%) samples had missing label information on the storage conditions and the address of the manufacturer.
Conclusions: Strict adherence to current Good Manufacturing Practices (cGMP) by manufacturers of povidone-iodine and chlorhexidine mouthwashes/gargles is necessary to guarantee quality assured products in the market. Regular post-market surveillance and regulatory enforcement of standards are instrumental in minimizing the circulation of poor-quality products.

D O, J.N O, A.S O. "Quantification and Characterization of Tannins in Plectranthus barbatus Andrews Water Extracts in Nyamira County, Kenya." Journal of Agriculture and Veterinary Sciences. . 2022;Articles in Press.
Wango GM. "Rejection: What Happens and Why Rejection Hurts so Deeply - and What to do About it." The Counsel-ling Magazine. 2022;2(1):25-30.
Ochieng’ P, Nyandega IA, Wambua B. "Spatial-temporal analysis of historical and projected drought events over Isiolo County. Kenya." Journal of Theor Appl Climatol, Austria, part of Springer Nature . 2022.
K G, T M, J N, MO O. "Studies on the ethnopharmacology, antimicrobial activity, and toxicity of Catha edulis (Vahl.) Endl., in Sprague Dawley rats.". 2022;([version 1; peer review: awaiting peer review]. F1000 Research 2022, 11:286):https://doi.org/10.12688/f1000research.109243.1.
Osiro OA, Kariuki DK, Gathece LW. "Synthesis and characterisation of ionomer-type cements from alkaline activated kaolinite." Non-crystalline solids: X. 2022;doi: https://doi.org/10.1016/j.nocx.2021.100079.
Rop K, Karuku GN, Mbui D. "Synthesis and characterization of biodegradable cellulose-based polymer hydrogel.". In: Nanotechnology in Paper and Wood Engineering Fundamentals, Challenges and Applications. Amsterdam: Elsevier Radarweg 29, PO Box 211, 1000 AE Amsterdam, Netherlands The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, United Kingdom 50 Hampshire Street, 5th Floor, Cambridge, MA 02139, United States Copyright © 2022 Elsevier Inc. All rights res; 2022.
Osiro OO, Kariuki DK, Joyce K G. "Synthesis and Characterization of Ionomer-type Cements from Alkalin-Activated Kaolinite." Journal of Non-Crystalline Solids-X. 2022;13(100079):2-10.
Zhang Y, Li L, Zhang H, Shang J, Li C, Naqvi SMZA, Birech Z, Hu J. "Ultrasensitive detection of plant hormone abscisic acid-based surface-enhanced Raman spectroscopy aptamer sensor." Analytical and Bioanalytical Chemistry. 2022;414:2757-2766 .
Muasya JN. "University Students Perceptions and Experiences of Quid Pro Quo Transactions in Kenya." Journal of Studies in Education . 2022;12(2):49-64.
J O’o, BN B, V M, I C. "The Unusual High Origin Radial Artery in a Black Kenyan Population; a Cadaveric Study." Ethiop J Health SCI. 2022;32(2):445-452. Abstract223352-article_text-545874-1-10-20220328.pdfWebsite

Abstract
BACKGROUND: The anatomy of the radial artery draws great interests among anatomists for its frequent involvement in variations. Equally, these variations have gained significant attention from clinicians because of the preference to use the radial artery for catheterization. The commonest of radial artery variations involve its site of origin. In published literature, data on this variations exist, but the prevalence of such variations in a Kenyan population has hitherto been unknown.
METHODS: Sixty-two upper limbs from 50 formalin-fixed cadavers were studied during dissection in the Department of Human Anatomy, University of Nairobi.
RESULTS: Fifty-four (87.1%) radial arteries arose within the cubital fossa, while eight (12.9%) had a high origin. Out of the eight high arteries, two (3.2%) branched off from the axillary artery, another two (3.2%) were branches of the proximal third of the brachial artery and four (6.5%) arose from the middle third of the brachial artery. The high origin radial arteries were more common on the right upper limbs (5 out of the 8 cases). Both axillary and brachial origins were seen bilaterally.
CONCLUSION: The present study details important variations in the anatomy of the radial artery in a Kenyan population. With the radial artery being utilized during clinical, surgical and radiological interventions so frequently, an increased understanding and anticipation of such topographic variances is paramount.

"ONLINE LEARNING AMONGST UNIVERSITY OF NAIROBI UNDERGRADUATE STUDENTS AMID COVID-19 PANDEMIC, KENYA.". In: ICTEL 2021 International Conference, Education and Teaching . The Tomlinson Centre, Queensbridge Road, London, UK; 2022.
Syvitski J, Ángel JR, Saito Y, Overeem I, Vörösmarty CJ, Wang H, Olago D. "Earth’s sediment cycle during the Anthropocene.". 2022;3(3):179-196. AbstractWebsite

The global sediment cycle is a fundamental feature of the Earth system, balancing competing factors such as orogeny, physical–chemical erosion and human action. In this Review, values of the magnitudes of several sources and sinks within the cycle are suggested, although the record remains fragmented with uncertainties. Between 1950 and 2010, humans have transformed the mobilization, transport and sequestration of sediment, to the point where human action now dominates these fluxes at the global scale. Human activities have increased fluvial sediment delivery by 215% while simultaneously decreasing the amount of fluvial sediment that reaches the ocean by 49%, and societal consumption of sediment over the same period has increased by more than 2,500%. Global warming is also substantially affecting the global sediment cycle through temperature impacts (sediment production and transport, sea ice cover, glacial ice ablation and loss of permafrost), precipitation changes, desertification and wind intensities, forest fire extent and intensity, and acceleration of sea-level rise. With progressive improvements in global digital datasets and modelling, we should be able to obtain a comprehensive picture of the impacts of human activities and climate warming.

Githiora-Murimi YW, Owuor MA, Abila R, Olago D, Oriaso S. "Integrating stakeholder preferences into ecosystem services mapping in Yala wetland, Kenya." Ecosystems and PeopleEcosystems and People. 2022;18(1):146-163. AbstractWebsite
n/a
Plisnier P-D, Kayanda R, MacIntyre S, Obiero K, Okello W, Vodacek A, Cocquyt C, Abegaz H, Achieng A, Akonkwa B, Albrecht C, Balagizi C, Barasa J, Abel Bashonga R, Bashonga Bishobibiri A, Bootsma H, Borges AV, Chavula G, Dadi T, De Keyzer ELR, Doran PJ, Gabagambi N, Gatare R, Gemmell A, Getahun A, Haambiya LH, Higgins SN, Hyangya BL, Irvine K, Isumbisho M, Jonasse C, Katongo C, Katsev S, Keyombe J, Kimirei I, Kisekelwa T, Kishe M, Otoung A. Koding S, Kolding J, Kraemer BM, Limbu P, Lomodei E, Mahongo SB, Malala J, Mbabazi S, Masilya PM, McCandless M, Medard M, Migeni Ajode Z, Mrosso HD, Mudakikwa ER, Mulimbwa N'sibula, Mushagalusa Déo, Muvundja FA, Nankabirwa A, Nahimana D, Ngatunga BP, Ngochera M, Nicholson S, Nshombo M, Ntakimazi G, Nyamweya C, Ikwaput Nyeko J, Olago D, Olbamo T, O'Reilly CM, Pasche N, Phiri H, Raasakka N, Salyani A, Sibomana C, Silsbe GM, Smith S, Sterner RW, Thiery W, Tuyisenge J, Van der Knaap M, Van Steenberge M, van Zwieten PAM, Verheyen E, Wakjira M, Walakira J, Ndeo Wembo O, Lawrence T. "Need for harmonized long-term multi-lake monitoring of African Great Lakes.". 2022. AbstractWebsite

To ensure the long-term sustainable use of African Great Lakes (AGL), and to better understand the functioning of these ecosystems, authorities, managers and scientists need regularly collected scientific data and information of key environmental indicators over multi-years to make informed decisions. Monitoring is regularly conducted at some sites across AGL; while at others sites, it is rare or conducted irregularly in response to sporadic funding or short-term projects/studies. Managers and scientists working on the AGL thus often lack critical long-term data to evaluate and gauge ongoing changes. Hence, we propose a multi-lake approach to harmonize data collection modalities for better understanding of regional and global environmental impacts on AGL. Climate variability has had strong impacts on all AGL in the recent past. Although these lakes have specific characteristics, their limnological cycles show many similarities. Because different anthropogenic pressures take place at the different AGL, harmonized multi-lake monitoring will provide comparable data to address the main drivers of concern (climate versus regional anthropogenic impact). To realize harmonized long-term multi-lake monitoring, the approach will need: (1) support of a wide community of researchers and managers; (2) political goodwill towards a common goal for such monitoring; and (3) sufficient capacity (e.g., institutional, financial, human and logistic resources) for its implementation. This paper presents an assessment of the state of monitoring the AGL and possible approaches to realize a long-term, multi-lake harmonized monitoring strategy. Key parameters are proposed. The support of national and regional authorities is necessary as each AGL crosses international boundaries.

Cohen AS, Campisano CJ, Arrowsmith RJ, Asrat A, Beck CC, Behrensmeyer AK, Deino AL, Feibel CS, Foerster V, Kingston JD, Lamb HF, Lowenstein TK, Lupien RL, Muiruri V, Olago DO, Owen BR, Potts R, Russell JM, Schaebitz F, Stone JR, Trauth MH, Yost CL. "Reconstructing the Environmental Context of Human Origins in Eastern Africa Through Scientific Drilling." Annual Review of Earth and Planetary SciencesAnnual Review of Earth and Planetary Sciences. 2022. AbstractWebsite

Paleoanthropologists have long speculated about the role of environmental change in shaping human evolution in Africa. In recent years, drill cores of late Neogene lacustrine sedimentary rocks have yielded valuable high-resolution records of climatic and ecosystem change. Eastern African Rift sediments (primarily lake beds) provide an extraordinary range of data in close proximity to important fossil hominin and archaeological sites, allowing critical study of hypotheses that connect environmental history and hominin evolution. We review recent drill-core studies spanning the Plio?Pleistocene boundary (an interval of hominin diversification, including the earliest members of our genus Homo and the oldest stone tools), and the Mid?Upper Pleistocene (spanning the origin of Homo sapiens in Africa and our early technological and dispersal history). Proposed drilling of Africa's oldest lakes promises to extend such records back to the late Miocene. ?High-resolution paleoenvironmental records are critical for understanding external drivers of human evolution. ?African lake basin drill cores play a critical role in enhancing hominin paleoenvironmental records given their continuity and proximity to key paleoanthropological sites. ?The oldest African lakes have the potential to reveal a comprehensive paleoenvironmental context for the entire late Neogene history of hominin evolution. Expected final online publication date for the Annual Review of Earth and Planetary Sciences, Volume 50 is May 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.Paleoanthropologists have long speculated about the role of environmental change in shaping human evolution in Africa. In recent years, drill cores of late Neogene lacustrine sedimentary rocks have yielded valuable high-resolution records of climatic and ecosystem change. Eastern African Rift sediments (primarily lake beds) provide an extraordinary range of data in close proximity to important fossil hominin and archaeological sites, allowing critical study of hypotheses that connect environmental history and hominin evolution. We review recent drill-core studies spanning the Plio?Pleistocene boundary (an interval of hominin diversification, including the earliest members of our genus Homo and the oldest stone tools), and the Mid?Upper Pleistocene (spanning the origin of Homo sapiens in Africa and our early technological and dispersal history). Proposed drilling of Africa's oldest lakes promises to extend such records back to the late Miocene. ?High-resolution paleoenvironmental records are critical for understanding external drivers of human evolution. ?African lake basin drill cores play a critical role in enhancing hominin paleoenvironmental records given their continuity and proximity to key paleoanthropological sites. ?The oldest African lakes have the potential to reveal a comprehensive paleoenvironmental context for the entire late Neogene history of hominin evolution. Expected final online publication date for the Annual Review of Earth and Planetary Sciences, Volume 50 is May 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

Beydon N, Ferkol T, Harris AL, Colas M, Davis SD, Haarman E, Hogg C, Kilbride E, Kouis P, Kuehni CE, Latzin P, Marangu D, Marthin J, Nielsen KG, Robinson P, Rumman N, Rutter M, Walker W, Lucas JS. "An international survey on nasal nitric oxide measurement practices for the diagnosis of primary ciliary dyskinesia." ERJ Open Res. 2022;8(2). Abstract

Nasal nitric oxide (nNO) measurements are used in the assessment of patients suspected of having primary ciliary dyskinesia (PCD), but recommendations for performing such measurements have not focused on children and do not include all current practices. To guide the development of a European Respiratory Society-supported technical standard for nNO measurement in children, an international online survey was conducted to better understand current measurement practices among providers involved in PCD diagnostics. 78 professionals responded, representing 65 centres across 18 countries, mainly in Europe and North America. Nearly all centres measured nNO in children and more than half performed measurements before 5 years of age. The test was often postponed in children with signs of acute airway infection. In Europe, the electrochemical technique was more frequently used than chemiluminescence. A similar proportion of centres performed measurements during exhalation against a resistance (49 out of 65) or during tidal breathing (50 out of 65); 15 centres used only exhalation against a resistance and 15 used only tidal breathing. The cut-off values used to discriminate PCD were consistent across centres using chemiluminescence analysers; these centres reported results as an output (nL·min). Cut-off values were highly variable across centres using electrochemical devices, and nNO concentrations were typically reported as ppb. This survey is the first to determine real-world use of nNO measurements globally and revealed remarkable variability in methodology, equipment and interpretation. These findings will help standardise methods and training.

QURESHI ZAHIDA, Jamner A, Filippi V, Gwako G, Osoti A, Mehrtash H, Baguiya A, Bello FA, Compaoré R, Gadama L, Kim CR, Msusa AT, Tunçalp Ӧ, Calvert C. "Level and determinants of contraceptive uptake among women attending facilities with abortion-related complications in East and Southern Africa." Int J Gynaecol Obstet. 2022;156 Suppl 1:27-35. Abstract

To investigate the level and determinants of nonreceipt of contraception among women admitted to facilities with abortion-related complications in East and Southern Africa.

Vannevel V, Vogel JP, Pattinson RC, Adanu R, Charantimath U, Goudar SS, Gwako G, Kavi A, Maya E, Osoti A, Pujar Y, Qureshi ZP, Rulisa S, Botha T, Oladapo OT. "Antenatal Doppler screening for fetuses at risk of adverse outcomes: a multicountry cohort study of the prevalence of abnormal resistance index in low-risk pregnant women." BMJ Open. 2022;12(3):e053622. Abstract

Few interventions exist to address the high burden of stillbirths in apparently healthy pregnant women in low- and middle-income countries (LMICs). To establish whether a trial on the impact of routine Doppler screening in a low-risk obstetric population is warranted, we determined the prevalence of abnormal fetal umbilical artery resistance indices among low-risk pregnant women using a low-cost Doppler device in five LMICs.

Mary T. Simiyu, Nyongesa FW, Birech Z, Njenga L, Ilin N, Thomas F. Krauss, Pitruzzello G, Aduda BO. "Application Of Molasses In Improving Water Purification Efficiency Of Diatomaceous Earth-Waste Ceramic Membranes.". In: EAI International Conference on Innovations and Interdisciplinary Solutions for Underserved Areas (INTERSOL 2022) . Nile University Of Nigeria Abuja ; 2022. Abstract

The World Health Organization predicts that 90.0% of the 2.3 million people who die annually due to water-borne diseases come from developing countries. At the same time fluorosis occurrence in the world’s geological fluoride belts has left many people maimed due to drinking highly fluoridated water. This work reports on the use of molasses in making carbon-activated diatomaceous earth waste (DE-waste) ceramic membranes with improved mechanical strength and water purification efficiency. The fabricated diatomaceous membranes were soaked in molasses for 24.0 hours and fired at 600.0 for 3.0 hours. The carbon-activated membranes were used to filter water contaminated with Escherichia coli, Rotavirus, and sodium fluoride. The activated carbon obtained in this work had a bulk density of 450.0 kg/m3 and it reduced the porosity of the DE-waste membranes by 18.0%. The activated carbon improved the modulus of rupture (MOR) of the DE-waste membrane by 47.8% and the average pore size of the active DE-waste membrane was 18.4 nm. The filtration process was found to be dependent on the contaminant’s size, concentration, and the external pressure applied to the water during the filtration process. The filtration efficiency of >99.9 in E. coli was concentration and pressure. Membranes reported efficiency of 97.1% and 98.9% in deflouridation and Rotavirus filtration. Thus, molasses is potential material in fabrication of water membranes

In Press
S. Z, G. C, I. V, G. B, D.M. H, K.M. M, J.R. B. "Adaptive radiation of the endemic Alcolapia cichlids of the East African soda lakes: genetic and morphological perspectives." Journal of Evolutionary Biology. In Press.
Oloo CM, Onyari JM, Wanyonyi WC, Wabomba JN, Muinde VM. "Adsorptive removal of hazardous crystal violet dye form aqueous solution using Rhizophora mucronata stem-barks: Equilibrium and kinetics studies." Environmental Chemistry and Ecotoxicology. In Press. AbstractEnvironmental Chemistry and Ecotoxicology

Description
Adsorption of crystal violet (CV) dye from aqueous solution using dried bark powder of mangrove species Rhizophora mucronata was studied. Characterization of adsorbent was done using FTIR and SEM. Batch experiment was carried out to examine the viability of using mangrove bark for adsorption of CV dye from aqueous solutions under different process conditions. The result revealed that removal of CV increased with contact time, adsorbent dose, initial dye concentration and decreased with increased particle size and ionic strength. pH 7 was the optimum pH for CV dye removal. The adsorption equilibrium for CV dye by Rhizophora mucronata stem-bark was attained within 60 min with removal efficacy of up to 99.8%. Pseudo-second-order kinetic model was best used to describe sorption kinetics while Freundlich isotherm model was appropriate for describing adsorption isotherm. The results demonstrated …

Atoh F. "Boniface Mganga.". In: Kenyan Musicians - A Biography Volume 2. Nairobi: Permanent Presidential Music Commission; In Press.
Etenyi JO, Okalebo FA, S.A. Opanga, K. A. Sinei, Osanjo GO, Kurdi A, Goodman B. Comparison of zidovudine and tenofovir based regimens with regard to quality of life and prevalence of syptoms in HIV patients in Kenya. Prague; In Press.
Kyule MD, Oyamo M. "Cultural resource management in Kenya: a case for legislation review.". In: Kenya from Independence to early 21st century. Nairobi: Nairobi University Press; In Press. Abstract

This paper builds a case for a reconsideration of Kenya’s legislation that relates to cultural and societal heritage resources management by briefly revisiting the circumstances that informed the enactment of the related laws. We present the view that existing legislation has tended to serve corporate, multinational and foreign interests at the expense of local and national interests, and that although these Acts may have somewhat served the country in the past, the legislations have turned the cultural heritage management in Kenya into a lame duck framework of abstractions of policy matters, that are irrelevant and unresponsive to changing local and international circumstances. We highlight contradictions between and within varied Acts, and offer suggestions for remedy that are geared toward the development of a cultural management policy with local ownership and universal compatibility.

JP E, J K, LW I, F H. "Description of pre-adult stages of the coconut bug, Pseudotherapthus wayi ." Journal of Insect Science . In Press.
Obiero JPO, Gumbe LO, Omuto CT, Hassan MA, Agullo JO. "Development of Pedotransfer functions for saturated hydraulic conductivity." Open Journal of Modern Hydrology. In Press.
Kemoli AM. "Dilemma of managing multi-surface dental caries in the primary dentition using the atraumatic restorative treatment: renaissance or dimming hope." East Afr Med J . In Press. Abstract

Background: Alot of research work has been carried out to determine the effectiveness of using atraumatic restorative treatment (ART) in the management of dental caries, but there are still unresolved issues surrounding the use of the technique particularly in very large carious lesions.
Objective: To determine the current survival rates of multi-surface ARTrestorations placed in the primary dentition and any consequences to the restored tooth after premature loss of the restoration.
Study selection: Using a set of specific key words, a Pubmed/Medline search was carried out to retrieve all publications on ARTrestorations placed in primary teeth in the period January 2000 to December 2011. Only publications whose studies had multi-surface ARTrestorations as an item of study were retrieved and relevant data extracted.
Data synthesis: Twelve studies contained in 12 publications fulfilled the selection criteria and were included in the study. The selected publications were analysed by the author to establish the study follow-up period and the survival rate of the multi-surface ARTrestorations for the different follow-up periods. Further information was adduced on any other effects of restoration on the tooth after premature loss of the restoration.
Results: The search findings indicated that the survival rate for most of the multi-surface restorations were generally very low. Further, there were indications that even after the premature loss of the ARTrestorations, most of the affected teeth survived for the period of the study with a number of them having shown no signs of secondary caries or associated dental abscessees.
Conclusion: While the survival rates of multi-surface ARTrestorations in the studies documenetd in the review were low, the ART restorations appeared to provide some beneficial effects to the retention-longevity of the restored tooth even after their premature loss.

Onjala J. "Economic Performance across Monetary Unions in Africa.". In: Aloysius Amin (ed) Monetary and Financial Institutions, Integration and Economic Performance in Africa. Palgrave Macmillan; In Press.
and Ndeke AN*1, 4 MHM1 KCK2 MJK1 BOAMZ3. "Effect of Acetaminophen on the Estrous Cycle and Reproductive Hormones of Female Mice." International Journal of Veterinary Science. In Press.ijvs-21-420-4-sc-kenya.pdf
D.O. O, Mavuti KM, Aloo-Obudho P, Ojuok JE, Britton JR. "Fish habitat suitability and community structure in an equatorial Lake Naivasha, Kenya. ." Hydrobiologia . In Press.
Sinei KA, Mwang JW. "An in vitro study on the oxytocic action action of Adenia Globosa Engl." East and Central African Journal of Pharmaceutical Sciences. In Press.
Mueni J. Kenyan women in music videos. Nairobi: Nairobi Academic Press; In Press.
Nzimbi BM, Luketero SW, Sitati IN, Musundi SW, Mwenda E. "On almost-similarity and metric equivalence of operators." Pioneer Journal of Mathematics and Mathematical Sciences(PJMMS)-accepted June 14, 2016. In Press.
Nzimbi BM, Kiratu BN, Sitati IN, Kipkemoi ST. "Remarks on the Murray-von Neumann equivalence of projections." International Journal of Pure and Applied Mathematics(IJPMAS)-accepted June 6, 2016. In Press.
"Revamping early childhood teacher education and professional development: Nuts and bolts for effective literacy and numeracy instruction." University of Dar es Salaam School of Education Journal of Education and Development. In Press.
"Six Ts for Effective and Efficient Early Grade Literacy Instruction.". In: Developing Languages in Africa: Social and Educational Perspectives. London: Cambridge University Press; In Press.
Muli CM, Musiga LA. "A Stochastic Model for Predicting Loan Portfolio Performance." Kenya Journal of Sciences. In Press.
MUTUKU DRNZIMBIBERNARD, KIBET DRMOINDISTEPHEN, P PROFPOKHARIYALGANESH. "W_4-Curvature tensor on a A-Einstein Sasakian manifold." Global Journal of Theoretical and Applied Mathematical Sciences(GJTAMS). In Press. Abstract

n/a

Submitted
.; Submitted. Abstract
n/a
.; Submitted. Abstract
n/a
.; Submitted. Abstract
n/a
u, (Eds.)..; Submitted. Abstract
n/a
.; Submitted. Abstract
n/a
.; Submitted. Abstract
n/a
.; Submitted. Abstract
n/a
.; Submitted. Abstract
n/a
ZHU (Eds.)..; Submitted. Abstract
n/a
. )E; Submitted. Abstract
n/a
.; Submitted. Abstract
n/a
.; Submitted. Abstract
n/a
.; Submitted. Abstract
n/a
.; Submitted. Abstract
n/a
.; Submitted. Abstract
n/a
.; Submitted. Abstract
n/a
.; Submitted. Abstract
n/a
.; Submitted. Abstract
n/a
.; Submitted. Abstract
n/a
.; Submitted. Abstract
n/a
.; Submitted. Abstract
n/a
.; Submitted. Abstract
n/a
.; Submitted. Abstract
n/a
.; Submitted. Abstract
n/a
.; Submitted. Abstract
n/a
.; Submitted. Abstract
n/a
.; Submitted. Abstract
n/a
.; Submitted. Abstract
n/a
.; Submitted. Abstract
n/a

UoN Websites Search