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O
MEROKA PROFMBECHEISAAC, Yego SK. " Operational Research Management Science in Social Issues at the Strategic Level.". In: Nairobi Journal of Management, Vol. 2,. IBIMA Publishing; 1996. Abstract

a paper presented to the Conference on Project Management in the Construction Industry for Eastern Africa Region, 20th - 23rd November, 1996, Machakos, Kenya.

S
Y E. " Sustainable Materials and Construction Technology.". In: AAK Mombasa Chapter: Seminar. Royal Court Hotel, Mombasa; 2006.
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Yenesew A., and Duddeck OJAH. "(R)-Prechrysophanol from Aloe graminicola." Phytochemistry . 1993;34 :1442-1444. Abstractpaper_13_yenesew_et_al_phyto_1993.pdf

From the subterranean stem of Aloe graminicola, a new pre-anthraquinone named prechrysophanol was isolated. Chrysophanol, helminthosporin, (R)-aloesaponol I, (R)-aloesaponol II, aloesaponarin I, aloesaponarin II and laccaic acid D methyl ester were also identified.

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Olwendo OJ, Yosuke Y, Cilliers PJ, Baki P, Chigomezyo MN, Mito C. ", A study on the response of the Equatorial Ionization Anomaly over the East Africa sector during the geomagnetic storm of November 13, 2012." . Advances in Space Research. 2015;55(12):2863-2872.
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Kariuki HN, Kanui TI, Yenesew A, Patel N, PM MPM. ". Antinociceptive and anti-inflammatory effects of Toddalia asiatica (L) Lam. (Rutaceae) root extract in Swiss albino mice." Pan African Medical journal. 2013;14:133.
Kamau FN, Njogui PM, Thoithi GN, Mwangi JW, Kibwage IO, Kariuki ST, Yenesew A, Mugoi HN, Mwalukumb JM. ". Phytochemical and Antimicrobial Investigation of Girardinia diversifolia (Link) Friis (Urticaceae).". 2011. Abstract

Root and stem extracts of Girardinia diversifolia exhibited varying degrees of activity against Bacillus pumilus, Staphylococcus aureus, Escherichia coli, Aspergillus niger, Candida albicans and Saccharomyces cerevisiae. Three compounds namely ~-sitosterol, 7bydroxysitosterol and 3-bydroxystigmast-5-en-7-one, were isolated from the petroleum ether root extract. The present study gives scientific credence to the traditional use of Girardinia diversifolia in the management of microbial infections.

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Yusuf A, Gitu P, Bhatt B, Njogu M, Salim A, Orata D. "1-Tetralinyl as carboxamide protecting group for asparagines and application to N-alpha-t-butyloxycarbonyl (Boc) solid-phase peptide synthesis of oxytocin." chemistry and materials research. 2014;6(2):1-11.
Yusuf A, Gitu P, Bhatt B, Njogu M, Salim A, Orata D. "1-Tetralinyl as Carboxamide-Protecting Group for Asparagine and Application to N-α-t-Butyloxycarbonyl (Boc) Solid-phase Peptide Synthesis of Oxytocin." chemistry and materials research. 2014;6(2). Abstractchemistry and materials research

Description
Oxytocin, a nonapeptide amide, was synthesized on a benzhydryl-resin using the Boc strategy. Benzyl group was used in the protection of sulfhydryl group of cysteine and tyrosine side-chain. Benzhydryl and tetralinyl groups were used in the protection of glutamine and asparagine side-chains respectively. TFMSA-TFA-thioanisole-1, 2-ethanedithiol (2: 20: 2: 1 v/v) was used on the peptide-resin under different cleavage conditions to obtain oxytocin in a one-pot reaction. The cleavage at 40 C for two hours gave oxytocin quantitatively. Oxytocin could be isolated in 56% yield.

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Mutai P, Heydenreich M, Thoithi G, Mugumbate G, Chibale K, Yenesew A. "3-Hydroxyisoflavanones from the stem bark of Dalbergia melanoxylon: Isolation, antimycobacterial evaluation and molecular docking." Phytochem. Lett.. 2013;6:671-675.
Yenesew A., Peggoty Mutai, Matthias Heydenreich GTGMKC. "3-Hydroxyisoflavanones from the stem bark of Dalbergia melanoxylon: Isolation, antimycobacterial evaluation and molecular docking studies." Phytochemistry Letters . 2013;6 :671-675. Abstractpaper_65_mutai_et_al_phyto_2013.pdf

Two new 3-hydroxyisoflavanones, (S)-3,4′,5-trihydroxy-2′,7-dimethoxy-3′-prenylisoflavanone (trivial name kenusanone F 7-methyl ether) and (S)-3,5-dihydroxy-2′,7-dimethoxy-2″,2″-dimethylpyrano[5″,6″:3′,4′]isoflavanone (trivial name sophoronol-7-methyl ether) along with two known compounds (dalbergin and formononetin) were isolated from the stem bark of Dalbergia melanoxylon. The structures were elucidated using spectroscopic techniques. Kenusanone F 7-methyl ether showed activity against Mycobacterium tuberculosis, whereas both of the new compounds were inactive against the malaria parasite Plasmodium falciparum at 10 μg/ml. Docking studies showed that the new compounds kenusanone F 7-methyl ether and sophoronol-7-methyl ether have high affinity for the M. tuberculosis drug target INHA.

Yenesew A, Atilaw Y, Heydenreich, Ndakala A, Hoseah M, Akala, M Kamau E. "3-Oxo-14α,15α-epoxyschizozygine: A new schizozygane indoline alkaloid from Schizozygia coffaeoides." Phytochemistry Letters . 2014;10:28-31. Abstractpaper_73_atilaw_et_al_phyto_2014.pdf

The stem bark extract of Schizozygia coffaeoides (Apocynaceae) showed moderate antiplasmodial activity (IC50 = 8–12 μg/mL) against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum. Chromatographic separation of the extract led to the isolation of a new schizozygane indoline alkaloid, named 3-oxo-14α,15α-epoxyschizozygine. In addition, two dimeric anthraquinones, cassiamin A and cassiamin B, were identified for the first time in the family Apocynaceae. The structures of the isolated compounds were deduced on the basis of spectroscopic evidence. The schizozygane indole alkaloids showed good to moderate antiplasmodial activities (IC50 = 13–52 μМ).

Atilaw Y, Heydenreich M, Ndakala A, Akala HM, Kamau E, Yenesew A. "3-Oxo-14α,15α-epoxyschizozygine: A new schizozygane indoline alkaloid from Schizozygia coffaeoides." Phytochemistry Letters. 2014;10:28-31.
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Yenesew A, Derese, S., Barasa, L., Akala HM, Yusuf, A.O., Kamau E, Heydenreich. "4'-Prenyloxyderrone from the stem bark of Millettia oblata ssp. teitensis and the antiplasmodial activities of isoflavones from some Millettia species." Phytochemistry Letters ,. 2014;8:69-72. Abstractpaper_68_derese_et_al_phyto_2014.pdf

The CH2Cl2/MeOH (1:1) extract of the stem bark of Millettia oblata ssp. teitensis showed antiplasmodial activity (IC50 = 10–12 μg/mL) against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum. Chromatographic separation of the extract led to the isolation of a new isoflavone, 4′-prenyloxyderrone (1), together with known isoflavones (8-O-methylretusin, durmillone, maximaisoflavone B, maximaisoflavone H and maximaisoflavone J), a rotenoid (tephrosin) and a triterpene (lupeol). Similar investigation of Millettia leucantha resulted in the identification of the isoflavones afrormosin and wistin, and the flavone chrysin. The identification of these compounds was based on their spectroscopic data. Five of the isoflavones isolated from these plants as well as 11 previously reported compounds from Millettia dura were tested and showed good to moderate antiplasmodial activities (IC50 = 13–53 μM), with the new compound, 4′-prenyloxyderrone, being the most active (IC50 = 13–15 μM).

6
Muiva L, Macharia B, Akala H, Derese S, Omosa LK, Yusuf A, Kamau E, Koch A, Heidenreich M, Yenesew A. "6a-Hydroxy-α-toxicarol and (+)-Tephrodin with antiplasmodial activities from Tephrosia species." Phytochemistry Letters. 2014;10:179-183.scan0062.pdf
Yenesew A, Muiva-Mutisya L, Macharia B, Heydenreich M, Andreas Koch, Hoseah M. Akala SDLOK. "6α-Hydroxy-α-toxicarol and (+)-Tephrodin with antiplasmodial activities from Tephrosia species." Phytochemistry Letters . 2014. Abstractpaper_75_muiva_et_al_phyto_2014.pdf

The CH2Cl2/MeOH (1:1) extract of the roots of Tephrosia villosa showed good antiplasmodial activity against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum with IC50 values of 3.1 ± 0.4 and 1.3 ± 0.3 μg/mL, respectively. Chromatographic separation of the extract yielded a new rotenoid, 6α-hydroxy-α-toxicarol, along with five known rotenoids, (rotenone, deguelin, sumatrol, 12a-hydroxy-α-toxicarol and villosinol). Similar treatment of the extract of the stem of Tephrosia purpurea (IC50 = 4.1 ± 0.4 and 1.9 ± 0.2 μg/mL against D6 and W2 strains of P. falciparum, respectively) yielded a new flavone having a unique substituent at C-7/C-8 [trivial name (+)-tephrodin], along with the known flavonoids tachrosin, obovatin methyl ether and derrone. The relative configuration and the most stable conformation in (+)-tephrodin was determined by NMR and theoretical energy calculations. The rotenoids and flavones tested showed good to moderate antiplasmodial activities (IC50 = 9 − 23 μМ). Whereas the cytotoxicity of rotenoids is known, the flavones (+)-tephrodin and tachrosin did not show significant cytotoxicity (IC50 > 100 μМ) against mammalian African monkey kidney (vero) and human larynx carcinoma (HEp2) cell lines.

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Yenesew A, Mushibe EK, Induli M, Derese S, Midiwo JO, Kabaru JM, Heydenreich M, Cock A, Peter MG. "7a-O-methyldeguelol, a modified rotenoid with an open ring--C, from the roots of Derris trifoliata." Phytochemistry. 2005;66:653-657.
Yenesew A. "7a-O-Methyldeguelol, a modified rotenoid with an open ring-C, from the roots of Derris trifoliata.." Phytochemistry . 2005;66:653-657. Abstractpaper_36_yenesew_et_al_phyto_2005_66_653.pdf

From the acetone extract of the roots of Derris trifoliata an isoflavonoid derivative, named 7a-O-methyldeguelol, a modified rotenoid with an open ring-C, representing a new sub-class of isoflavonoids (the sub-class is here named as rotenoloid), was isolated and characterised. In addition, the known rotenoids, rotenone, deguelin and a-toxicarol, were identified. The structures were determined on the basis of spectroscopic evidence. Rotenone and deguelin were identified as the larvicidal principles of the acetone extract of the roots of Derris trifoliata.

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Yenesew A, N A, Heydenreich M, Midiwo JO, Ndakala A, Majer Z, Neumann B, Stammler H-G, Sewald N. "8-Hydroxy-6-methylxanthone-1-carboxylic acid and 6',8-O-dimethylknipholone from the roots of Bulbine frutescens." Phytochemistry Letters . 2014;9:67-73. Abstractpaper_70_abdissa_et_al_phyto_2014.pdf

Phytochemical investigation of the dichloromethane/methanol (1:1) extract of the roots of Bulbine frutescens led to the isolation of a new xanthone, 8-hydroxy-6-methylxanthone-1-carboxylic acid (1) and a new phenylanthraquinone, 6′,8-O-dimethylknipholone (2) along with six known compounds. The structures were elucidated on the basis of NMR and MS spectral data analyses. The structure of compound 1 was confirmed through X-ray crystallography which was then used as a reference to propose the revision of the structures of six seco-anthraquinones into xanthones. The isolated compounds were evaluated for cytotoxicity against human cervix carcinoma KB-3-1 cells with the phenylanthraquinone knipholone being the most active (IC50 = 0.43 μM). Two semi-synthetic knipholone derivatives, knipholone Mannich base and knipholone-1,3-oxazine, were prepared and tested for cytotoxic activity; both showed moderate activities (IC50 value of 1.89 and 2.50 μM, respectively).

Yenesew A. "8-Methoxyneorautenol and Radical Scavenging flavonoids from Erythrina abyssinica." Bull. Chem. Soc. Ethiopia . 2009;23:205-210. Abstractpaper_47_yenesew_et_l_bull_chem_soc_ethiop-2009-23-205.pdf

A new pterocarpan (named 8-methoxyneorautenol) was isolated from the acetone extract of the
root bark of Erythrina abyssinica. In addition, the known isoflavonoid derivatives eryvarin L, erycristagallin and
shinpterocarpin were identified for the first time from the roots of this plant. The structures were determined on the basis of spectroscopic evidence. The new compound showed selective antimicrobial activity against
Trichophyton mentagrophytes. The acetone extract of the root bark of E. abyssinica showed radical scavenging activity towards 2,2-diphenyl-1-picrylhydrazyl radical (DPPH). The pterocarpenes, 3-hydroxy-9-methoxy-10-(3,3-dimethylallyl)pterocarpene and erycristagallin, were the most active constituents of the roots of this plant and showing dose-dependent activities similar to that of the standard quercetin.

KEY WORDS: Erythrina abyssinica, Root bark, Leguminosae, Pterocarpan, 8-Methoxyneorautenol,
Pterocarpenes, 3-Hydroxy-9-methoxy-10-(3,3-dimethylallyl)pterocarpene, Erycristagallin, Antimicrobial, Radical scavengers, DPPH

A
Kinuthia RK, Mureithi SM, Young TP, Njoka TJ, Otieno SG. "Aboveground Net Primary Productivity in Grazed and Ungrazed pastures: Grazing Optimisation Hypothesis or Local Extinction of Vegetation Species.". 2009. Abstract

The controversy that has surrounded herbivory studi es in the last few decades prompted our investigati on to establish the extent to which herbivore optimisatio n hypothesis or compensatory growth evidence is rea l. We used the traditional movable cage method to collect primary productivity data on herbage, functional g roups and key individual grass species in various controlled large herbivore treatments in an east African savan na. The herbivore treatments in triplicate blocks included cattle, wild herbivores with and without mega herbi vores and combinations of cattle and wild herbivores also wit h and without mega herbivores. The findings reveale d that at herbage level, most grazed treatments (four out of five) had higher productivity than the ungrazed con trol and three showed grazing optimisation curve at sixth po lynomial degree between monthly productivity and gr azing intensity (1-g/ng). At functional group level forbs productivity was higher in the ungrazed control th an in any of the grazed treatments while at individual grass spe cies level Themeda triandra productivity was higher in all grazed treatments than in ungrazed control. We conc lude against presence of herbivore optimisation hyp othesis at herbage, functional group and species level beca use of lack of attributable grazing effect in graze d treatments that matches complex ecological effects in the ungr azed treatment.

Zhao S, Tian H, Ma L, Yuan Y, Yu RC, Ma M. "Activity-{Dependent} {Modulation} of {Odorant} {Receptor} {Gene} {Expression} in the {Mouse} {Olfactory} {Epithelium}." PLoS ONE. 2013;8:e69862. AbstractWebsite

Activity plays critical roles in development and maintenance of the olfactory system, which undergoes considerable neurogenesis throughout life. In the mouse olfactory epithelium, each olfactory sensory neuron (OSN) stably expresses a single odorant receptor (OR) type out of a repertoire of ∼1200 and the OSNs with the same OR identity are distributed within one of the few broadly-defined zones. However, it remains elusive whether and how activity modulates such OR expression patterns. Here we addressed this question by investigating OR gene expression via in situ hybridization when sensory experience or neuronal excitability is manipulated. We first examined the expression patterns of fifteen OR genes in mice which underwent neonatal, unilateral naris closure. After four-week occlusion, the cell density in the closed (sensory-deprived) side was significantly lower (for four ORs), similar (for three ORs), or significantly higher (for eight ORs) as compared to that in the open (over-stimulated) side, suggesting that sensory inputs have differential effects on OSNs expressing different OR genes. We next examined the expression patterns of seven OR genes in transgenic mice in which mature OSNs had reduced neuronal excitability. Neuronal silencing led to a significant reduction in the cell density for most OR genes tested and thinner olfactory epithelium with an increased density of apoptotic cells. These results suggest that sensory experience plays important roles in shaping OR gene expression patterns and the neuronal activity is critical for survival of OSNs.

Hayano Y, Yamamoto N. "Activity-{Dependent} {Thalamocortical} {Axon} {Branching}." The Neuroscientist. 2008;14:359-368. AbstractWebsite
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Tung CS, Chu KM, Tseng CJ, Yin TH. "Adenosine in hemorrhagic shock: possible role in attenuating sympathetic activation." Life Sci.. 1987;41(11):1375-82. Abstract

Changes in plasma purine nucleoside level, autonomic activity and hemodynamic reactions were studied in pentobarbital anesthetized rabbits during hemorrhagic shock. Shock was elicited by bleeding the animals to a mean blood pressure of 40 mmHg and maintained until 60% of the maximum bleeding volume in the reservoir had been taken up spontaneously. The remaining shed blood was reinfused thereafter. Norepinephrine (NE), epinephrine (E), adenosine (AD) and uric acid were measured by HPLC with electrochemical detection, fluorometry or UV absorbance. The results showed hemorrhagic shock caused a significant rise in plasma NE, E, AD, and uric acid levels, but the magnitudes and time profiles were different among them. Plasma NE and E increased during the shock compensatory period then declined in the decompensation period whereas adenosine and its metabolite uric acid were elevated persistently during both periods. It is concluded that a balance between autonomic activity and tissue metabolism is important in the maintenance of hemodynamics during shock.

Mwaniki JM, Onyatta JO, Yusuf AO. "Adsorption of Heavy Metal Ions from Aqueous Solutions and Wastewater using Water Hyacinth Powder ." International Journal of Trend in Scientific Research and Development (IJTSRD) . 2019;4(1):1-5.
Yenesew A., Dagne E. "Alkaloids of Teclea nobilis." Phytochemistry . 1988;27: 651-653. Abstractpaper_3_yenesew_et_al_phyto_1988.pdf

A new furoquinoline alkaloid to which we have assigned the trivial name nobiline, and seven other quinonline alkaloids were isolated and identified from the leaves and fruits of Teclea nobilis, an African medicinal plant.

Yaouba S, Koch A, Guantai EM, Derese S, Irungu B, Heydenreich M, Yenesew A. "Alkenyl cyclohexanone derivatives from Lannea rivae and Lannea schweinfurthii." Phytochemistry letters. 2018;23:141-148. AbstractJornal article

Abstract
Phytochemical investigation of the CH2Cl2/MeOH (1:1) extract of the roots of Lannea rivae (Chiov) Sacleux (Anacardiaceae) led to the isolation of a new alkenyl cyclohexenone derivative: (4R,6S)-4,6-dihydroxy-6-((Z)-nonadec-14′-en-1-yl)cyclohex-2-en-1-one (1), and a new alkenyl cyclohexanol derivative: (2S*,4R*,5S*)-2,4,5-trihydroxy-2-((Z)-nonadec-14′-en-1-yl)cyclohexanone (2) along with four known compounds, namely epicatechin gallate, taraxerol, taraxerone and β-sitosterol; while the stem bark afforded two known compounds, daucosterol and lupeol. Similar investigation of the roots of Lannea schweinfurthii (Engl.) Engl. led to the isolation of four known compounds: 3-((E)-nonadec-16′-enyl)phenol, 1-((E)-heptadec-14′-enyl)cyclohex-4-ene-1,3-diol, catechin, and 1-((E)-pentadec-12′-enyl)cyclohex-4-ene-1,3-diol. The structures of the isolated compounds were determined by NMR spectroscopy and mass spectrometry. The absolute configuration of compound 1 was established by quantum chemical ECD calculations. In an antibacterial activity assay using the microbroth kinetic method, compound 1 showed moderate activity against Escherichia coli while compound 2 exhibited moderate activity against Staphylococcus aureus. Compound 1 also showed moderate activity against E. coli using the disc diffusion method. The roots extract of L. rivae was notably cytotoxic against both the DU-145 prostate cancer cell line and the Vero mammalian cell line (CC50 = 5.24 and 5.20 μg/mL, respectively). Compound 1 was also strongly cytotoxic against the DU-145 cell line (CC50 = 0.55 μg/mL) but showed no observable cytotoxicity (CC50 > 100 μg/mL) against the Vero cell line. The roots extract of L. rivae and L. schweinfurthii, epicatechin gallate as well as compound 1 exhibited inhibition of carageenan-induced inflammation.

Graphical abstract

Cruickshank DL, Y. Y, Njuguna NM, Ongarora DSB, Chibale K, Caira MR. "Alternative solid-state forms of a potent antimalarial aminopyridine: X-ray crystallographic, thermal and solubility aspects." CrystEngComm. 2014;16:5781-5792.
Hawary, El., Yumoto, K., Yamazaki, Y., Mahrous, A., Ghamry, E., Meloni, A., Badi K, Kianji, G., Uiso CBS, Mwiinga N, Joao, L., Affluo, T., Sutcliffe, P.R., Mengestu, G., Baki, P., Abe, Ikeda, A., Fujimoto A. Annual and semi-annual Sq variations at 960 MM MAGDAS I and II stations in Africa, Earth and planets Space. Earth and planets space; 2012.
Hawary ELR, Yumoto K, Yamazaki Y, Mahrous A, Ghamry E, Meloni A, Badi K, Kianji G, Uiso CBS, Mwinge N, Joao L, Affluo T, Malinga S, Mengeshtu G, Baki P. Annual and semi-annual Sq variations at 960 MM MAGDAS I and II stations in Africa, Earth and planets Space. KOGOSHIMA, JAPAN; 2009.
Yenesew A., Dagne E. "Anthraquinones and the chemotaxonomy of the Asphodelaceae." Pure & Appl. Chem. . 1994;66: 2395-2398. Abstractpaper_16_dagne_et_al_pure__appl_chem-1994.pdf

Phytochemical investigations on three genera of the Asphodelaceae, Aloe, KniphoJla and Bulbine showed that 1-methyl-8-hydroxyanthraquinones and anthrone-C-glycosides are characteristic constituents of the genus Aloe, while knipholone-type compounds distinguish fiiphoja and Bulbine.

Endale M, Ekberg A, Alao JP, Akala HM, Ndakala A, Sunnerhagen P, Erdelyi M, Yenesew A. "Anthraquinones of the roots of Pentas micrantha." Molecules. 2013;18:311-321.
Derese S, Yenesew A, Midiwo JO, Heydenreich, Peter MG. "Anthraquinones, Pre-anthraquinones And Isoeleutherol In The Roots Of Aloe Species."; 1994.
Yenesew A., and E. Dagne, S. Asmellash DMSS. "Anthraquinones, pre-anthraquinones and Isoeleutherol in the roots of Aloe species." Phytochemistry . 1994;35:401-406. Abstractpaper_14_dagne_et_al_phyto_1994_35_401.pdf

Comparative TLC analysis of the root extracts of 32 Aloe species showed that chrysophanol, asphodelin, chrysophanol-8-methyl ether, aloechrysone, helminthosporin, aloesaponol III, aloesaponarin I, aloesaponol I, aloesaponarin II, aloesaponol II and laccaic acid D-methyl ester are widely distributed in these plants. Isoeleutherol, which is reported here for the first time as a natural product, occurs only in the Saponariae series of Aloe. The chemotaxonomic implication of the distribution of these compounds for the genus Aloe is discussed.

Yenesew A, Endale M, M., Erdelyi, Ekberg A, HM A, Ndakala A, A., Sunnerhagen. "Anthraquinonesof the roots of Pentas micrantha." Molecules . 2013;18,:311-321. Abstractpaper_61_endale_et_al_molecules-2013-18-00311.pdf

Pentas micrantha is used in the East African indigenous medicine to treat malaria. In the first investigation of this plant, the crude methanol root extract showed moderate antiplasmodial activity against the W2- (3.37 μg/mL) and D6-strains (4.00 μg/mL) of Plasmodium falciparum and low cytotoxicity (>450 μg/mL, MCF-7 cell line). Chromatographic separation of the extract yielded nine anthraquinones, of which 5,6-dihydroxylucidin-11-Omethyl ether is new. Isolation of a munjistin derivative from the genus Pentas is reported
here for the first time. The isolated constituents were identified by NMR and mass spectrometric techniques and showed low antiplasmodial activities.

Keywords: anthraquinone; malaria; Pentas micrantha; Rubiaceae; 5,6-dihydroxylucidin-11-O-methyl ether 1.

Yenesew A., and E. Dagne MSMW. "An anthrone, anthraquinone and two oxanthrones from Kniphofia foliosa." Phytochemistry . 1994;37:525-528. Abstractpaper_15_yenesew_et_al_phyto_1994_37_525.pdf

The compounds isoknipholone, isoknipholone anthrone, foliosone and isofoliosone were isolated from the stem of Kniphofia foliosa and their structures determined by spectral analyses. In addition, the known compounds, aloesaponol Ill, aloesaponol III-8-methyl ether and 4,6-dihydroxy-2-methoxyacetophenone were isolated and identified.

Drannik AG, Nag K, Yao X-D, Henrick BM, Jain S, Ball BT, Plummer FA, Wachihi C, Kimani J, Rosenthal KL. "Anti-HIV-1 Activity of Elafin Is More Potent than Its Precursor's, Trappin-2, in Genital Epithelial Cells.". 2012. AbstractWebsite

Cervicovaginal lavage fluid (CVL) is a natural source of anti-HIV-1 factors; however, molecular characterization of the anti-HIV-1 activity of CVL remains elusive. In this study, we confirmed that CVLs from HIV-1-resistant (HIV-R) compared to HIV-1-susceptible (HIV-S) commercial sex workers (CSWs) contain significantly larger amounts of serine antiprotease trappin-2 (Tr) and its processed form, elafin (E). We assessed anti-HIV-1 activity of CVLs of CSWs and recombinant E and Tr on genital epithelial cells (ECs) that possess (TZM-bl) or lack (HEC-1A) canonical HIV-1 receptors. Our results showed that immunodepletion of 30% of Tr/E from CVL accounted for up to 60% of total anti-HIV-1 activity of CVL. Knockdown of endogenous Tr/E in HEC-1A cells resulted in significantly increased shedding of infectious R5 and X4 HIV-1. Pretreatment of R5, but not X4 HIV-1, with either Tr or E led to inhibition of HIV-1 infection of TZM-bl cells. Interestingly, when either HIV-1 or cells lacking canonical HIV-1 receptors were pretreated with Tr or E, HIV-1 attachment and transcytosis were significantly reduced, and decreased attachment was not associated with altered expression of syndecan-1 or CXCR4. Determination of 50% inhibitory concentrations (IC50) of Tr and E anti-HIV-1 activity indicated that E is ~130 times more potent than its precursor, Tr, despite their equipotent antiprotease activities. This study provides the first experimental evidence that (i) Tr and E are among the principal anti-HIV-1 molecules of CVL; (ii) Tr and E affect cell attachment and transcytosis of HIV-1; (iii) E is more efficient than Tr regarding anti-HIV-1 activity; and (iv) the anti-HIV-1 effect of Tr and E is contextual

Yenesew A. "Anti-plasmodial activities of flavonoids from Erythrina sacleuxii." Planta Medica . 2006;72:187-189. Abstractpaper_39_andayi_et_al_planta_med.-_2006_antiplasmodial_flavonoids_from_erythrina_sacleuxii.pdf

The acetone extracts of the root bark and stem bark of Erythrina sacleuxii showed antiplasmodial activities against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum. Chromatographic separation of the acetone extract of the root bark afforded a new isoflavone, 7-hydroxy-4'-methoxy-3'-prenylisoflavone (trivial name 5-deoxy-3'-prenylbiochanin A) along with known isoflavonoids as the antiplasmodial principles. Flavonoids and isoflavonoids isolated from the stem bark of E. sacleuxii were also tested and showed antiplasmodial activities. The structures were determined on the basis of spectroscopic evidence.

Yenesew A. "Anti-plasmodial Flavonoids from the roots of Erythrina abyssinica." Phytochemistry. 2004; 65:3029-3032. Abstractpaper_35_yenesew_et_al_phyto_2004-erythrina_abyssinica.pdf

The ethyl acetate extract of the stem bark of Erythrina abyssinica showed anti-plasmodial activity against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum with IC50 values of 7.9 ± 1.1 and 5.3 ± 0.7 lg/ml, respectively. From this extract, a new chalcone, 20,3,4,40-tetrahydroxy-5-prenylchalcone (trivial name 5-prenylbutein) and a new flavanone, 40,7-dihydroxy-30-methoxy-50-prenylflavanone (trivial name, 5-deoxyabyssinin II) along with known flavonoids have been isolated as the anti-plasmodial principles. The structures were determined on the basis of spectroscopic evidence.

Waiganjo N, Yole D, Ochanda H. "Anti-schistosomal activity of five plant extracts on Swiss white mice infected with Schistosoma mansoni." IOSR Journal of Pharmacy and Biological Sciences. 2014;9 :49-53.
Waiganjo N, Yole D, Ochanda H. Anti-Schistosomal activity of five plant extracts on Swiss white mice infected with Schistosoma mansoni.; 2016. AbstractWebsite

Schistosomiasis in humans is a major public health problem worldwide. Schistosomiasis occurs
in 76 tropical countries and it is estimated that 85% of the infections are in Africa. In Kenya, it is estimated that
3 million people are infected. The Conventional drugs are effective in the treatment of the disease but very little
progress has been achieved on treatment of Schistosomiasis in Kenya. Any effort towards developing alternative
drugs for the disease is worthwhile. Praziquantel is the most effective drug against all adult stages of human
Schistosomiasis, being the drug of choice for morbidity control of Schistosomiasis. However it is not a satisfying
situation to have one drug used for the treatment. Ideally other drugs should be availed in order to avoid
development of drug resistance. The use of plant extracts in treatment of diseases is universal. The results
obtained showed that Ocimum americanum and Bridelia micrantha plant extracts had antischistosomal activity
as indicated by high worm reduction and reduced gross pathology. Histopathology showed no or few
granuloma in the liver tissue. Further work should be done on the efficacious extracts, towards drug
development.
Keywords: Antischistosomal activity, Pathology, Plant extracts, Praziquantel, Schistosomiasis

Ndakala AJ, Gessner RK, Gitari PW, October N, White KL, Hudson A, Fakorede F, Shackleford DM, Kaiser M, Yeates C, Charman SA, Chibale K. "Antimalarial Pyrido[1,2-a]benzimidazoles." Journal of Medicinal Chemistry. 2011;54:4581-4589.Website
Yenesew A. "Antimicrobial activities of a new schizozygane indoline alkaloid from Schizozygia coffaeoides and the revised structure of isoschizogaline." Journal of Natural Products. 2002;65:566-569. Abstractpaper_28_kariba_et_al_j.nat_._prod._2002.pdf

Extracts from Schizozygia coffaeoides showed antimicrobial activity against fungal and bacterial species. Alkaloids isolated using bioassay-guided fractionation were isoschizogaline, schizogynine, and a new indoline alkaloid, 7,8-dehydro-19beta-hydroxyschizozygine, shown to be the most active antifungal compound. The structure of isoschizagaline, the only active antibacterial, is revised on the basis of NMR analysis.

Yenesew A. "Antimicrobial and Anticancer Carvotacetone Derivativesof Sphaeranthus." Natural Product Communications . 2012;7:1123-1126. Abstractpaper_58_machumi_npc_publication-sphaeranthus_bullatus-2012.pdf

The CH2Cl2-MeOH (1:1) extract of the aerial parts of Sphaeranthus bullatus, an annual herb native to tropical East Africa, showed activity against chloroquine sensitive D6 (IC50 9.7 μg/mL) and chloroquine resistant W2 (IC50 15.0 μg/mL) strains of Plasmodium falciparum. Seventeen secondary metabolites were isolated from the extract through conventional chromatographic techniques and identified using various spectroscopic methods. The compounds were evaluated for their in vitro antiplasmodial, antileishmanial and anticancer activities revealing activity of four carvotacetone derivatives, namely 3-acetoxy-7-hydroxy-5-tigloyloxycarvotacetone (1), 3,7-dihydroxy-5-tigloyloxycarvotacetone (2), 3-acetoxy-5,7-dihydroxycarvotacetone (3) and 3,5,7-trihydroxycarvotacetone
(4); with antiplasmodial IC50 values of 1.40, 0.79, 0.60 and 3.40 μg/mL, respectively, against chloroquine sensitive D6 strains of P. falciparum;
antiplasmodial activity of IC50 2.00, 0.90, 0.68 and 2.80 μg/mL, respectively, against chloroquine resistant W2 strains of P. falciparum; antileishmanial IC50
values of 0.70, 3.00, 0.70 and 17.00 μg/mL, respectively, against the parasite L. donovanii promastigotes, and anticancer activity against human SK-MEL, KB,
BT-549 and SK-OV-3 tumor cells, with IC50 values between <1.1 - 5.3 μg/mL for 1-3. In addition, cytotoxic effects of the active compounds were evaluated against monkey kidney fibroblasts (VERO) and pig kidney epithelial cells (LLC-PK11). The structures of carvotacetone derivatives were determined by 1D and 2D NMR spectroscopy; the absolute stereochemical configuration of 3-acetoxy-7-hydroxy-5-tigloyloxycarvotacetone (1) was determined as 3R, 4R, 5S by circular dichroism, specific rotation, 1H NMR and 2D NMR ROESY and NOESY experiments.

Keywords: Sphaeranthus bullatus, Asteraceae, Antiplasmodial, Antileishmanial, Anticancer, Carvotacetones.

Yenesew A., Machumi, F. SDMWJTKWVSJ. "Antimicrobial and Antiparasitic Abietane Diterpenoids from the roots of Clerodendrum eriophyllum." Natural Product Communications . 2010;5 :853-858. Abstractpaper_49_machumi_et_al-npc-2010.pdf

Chromatographic separation of the roots of a Kenyan medicinal plant, Clerodendrum eriophyllum, led to the isolation of ten abietane diterpenoids (1-10), one of which (1) was isolated for the first time from a natural source. Using spectroscopic data, the structure of 1 was determined to be 12-hydroxy-8,12-abietadiene-3,11,14-trione. Circular dichroism (CD) spectra showed that the stereochemistry of compounds 1, 3, and 6-8 belongs to the normal series of abietane diterpenes, which confirmed the absolute stereochemistry of the isolated compounds. Compounds 1-10 were evaluated for their in vitro antiplasmodial, antileishmanial, antifungal and antibacterial activities. Compounds 3 and 7 exhibited potent antifungal activity (IC50/MIC 0.58/1.25 and 0.96/2.5 microg/mL, respectively) against C. neoformans, whereas 3, 6 and 7 showed strong antibacterial activity against Staphylococcus aureus and methicillin-resistant S. aureus with IC50/MIC values between 1.33-1.75/2.5-5 and 0.96-1.56/2.5 microg/mL, respectively. In addition, compounds 3 and 9 exhibited potent antileishmanial activity (IC50 0.08 and 0.20 microg/mL, respectively) against L. donovani, while 3 and 7 displayed weak antimalarial activity against Plasmodium falciparum, but 9 was inactive

Omosa LK, Amugune B, Ndunda B, Milugo TK, Heydenreich M, Yenesew A, Midiwo JO. "Antimicrobial flavonoids and diterpenoids from Dodonaea angustifolia." South African Journal of Botany. 2014;91:58-62.omosa_eet_al._sajb.pdf
Yenesew A, L. K., Omosa, Beatrice, Amugune, Ndunda B, Milugo TKTK, Heydenreich M, Midiwo JO. "Antimicrobial flavonoids and diterpenoids from Dodonaea angustifolia." South African Journal of Botany. . 2014;91, :58-62. Abstractpaper_67_omosa_et_al_south_africa_jou..2014.pdf

The surface exudates of the leaves of Dodonaea angustifolia from Ngong forest population (6 km from Nairobi city center, Kenya) demonstrated antimicrobial activity against Gram-negative (Escherichia coli), Gram-positive (Staphylococcus aureus and Bacillus pumilus) bacteria and the fungus Sacchromyces cerevisiae. Chromatographic separation of the exudates yielded eight methylated flavonoids; 5-hydroxy-3, 4′,7-trimethoxyflavone (1), 3,5-dihydroxy-4′,7-dimethoxyflavone (2), santin (3), kumatakenin (4), rhamnocitrin (5), isokaempferide (6), 3,4′,5,7, tetrahydroxy-6-methoxyflavone (7), pinocembrin (8); two clerodanes, dodonic acid (9) and 2β-hydroxyhardwickiic acid (10) and one labdane; (ent-3β,8α)-15,16-epoxy-13(16),14-labdadiene-3,8-diol (11) diterpenoids. The flavonoid aglycones; 6, 7 and the clerodane diterpenoids; 9 and 10 and labdane diterpenoid, 11 were isolated for the first time from this plant species. The structures of the isolated compounds were identified using ultraviolet (UV), mass spectroscopy (MS), one dimension (1D) and two dimension (2D) nuclear magnetic resonance (NMR) spectroscopy and by comparison of the spectral data with literature. The quercetin derivative, 3,4′,5-trihydroxy-3′,7-dimethoxyflavone (12) showed broad spectrum antibacterial activities against E. coli and B. pumilus with minimum inhibition concentration (MIC) values less than 31.25 μg/well and against S. aureus with MIC below 62.5 μg/well. This compound showed poor antifungal activity against S. cerevisiae (MIC < 500 μg/well). Good antifungal activities were observed for 5,4′-dihydroxy-7-methoxyflavanone (13) and hautriwaic acid lactone (14) against S. cerevisiae with MIC values less than 7.8 μg/well. The most active antifungal compound was 5,7-dihydro-3,4′,6-trimethoxyflavone (3, santin) with an MIC value less than 3.9 μg/well against S. cerevisiae. The rest of the compounds exhibited weak to moderate activities. For comprehensive structure activity relationship studies (SAR), hautriwaic acid lactone (14), hautriwaic acid (15), penduletin (16) isolated from the surface exudates of D. angustifolia from Voi (200 km from Mombasa city center, Kenya) and 12 and 13 from Senecio roseiflorus isolated earlier were included in the bioassays.

Omosa LK, Amugune B, Ndunda B, Milugo TK, Heydenreich M, Yenesew A, Midiwo JO. "Antimicrobial flavonoids and diterpenoids from Dodonaea angustifolia." South African Journal of Botany. 2014. Abstract

The surface exudates of the leaves of Dodonaea angustifolia from Ngong forest population (6 km from Nairobi city center, Kenya) demonstrated antimicrobial activity against Gram-negative (Escherichia coli), Gram-positive (Staphylococcus aureus and Bacillus pumilus) bacteria and the fungus Sacchromyces cerevisiae. Chromatographic separation of the exudates yielded eight methylated flavonoids; 5-hydroxy-3, 4′,7-trimethoxyflavone (1), 3,5-dihydroxy-4′,7-dimethoxyflavone (2), santin (3), kumatakenin (4), rhamnocitrin (5), isokaempferide (6), 3,4′,5,7, tetrahydroxy-6-methoxyflavone (7), pinocembrin (8); two clerodanes, dodonic acid (9) and 2β-hydroxyhardwickiic acid (10) and one labdane; (ent-3β,8α)-15,16-epoxy-13(16),14-labdadiene-3,8-diol (11) diterpenoids. The flavonoid aglycones; 6, 7 and the clerodane diterpenoids; 9 and 10 and labdane diterpenoid, 11 were isolated for the first time from this plant species. The structures of the isolated compounds were identified using ultraviolet (UV), mass spectroscopy (MS), one dimension (1D) and two dimension (2D) nuclear magnetic resonance (NMR) spectroscopy and by comparison of the spectral data with literature. The quercetin derivative, 3,4′,5-trihydroxy-3′,7-dimethoxyflavone (12) showed broad spectrum antibacterial activities against E. coli and B. pumilus with minimum inhibition concentration (MIC) values less than 31.25 μg/well and against S. aureus with MIC below 62.5 μg/well. This compound showed poor antifungal activity against S. cerevisiae (MIC < 500 μg/well). Good antifungal activities were observed for 5,4′-dihydroxy-7-methoxyflavanone (13) and hautriwaic acid lactone (14) against S. cerevisiae with MIC values less than 7.8 μg/well. The most active antifungal compound was 5,7-dihydro-3,4′,6-trimethoxyflavone (3, santin) with an MIC value less than 3.9 μg/well against S. cerevisiae. The rest of the compounds exhibited weak to moderate activities. For comprehensive structure activity relationship studies (SAR), hautriwaic acid lactone (14), hautriwaic acid (15), penduletin (16) isolated from the surface exudates of D. angustifolia from Voi (200 km from Mombasa city center, Kenya) and 12 and 13 from Senecio roseiflorus isolated earlier were included in the bioassays.

Omosa LK, Amugune B, Ndunda B, Milugo TK, Heydenreich M, Yenesew A, Midiwo JO. "Antimicrobial flavonoids and diterpenoids from Dodonaea angustifolia." South African Journal of Botany. 2014. Abstract

The surface exudates of the leaves of Dodonaea angustifolia from Ngong forest population (6 km from Nairobi city center, Kenya) demonstrated antimicrobial activity against Gram-negative (Escherichia coli), Gram-positive (Staphylococcus aureus and Bacillus pumilus) bacteria and the fungus Sacchromyces cerevisiae. Chromatographic separation of the exudates yielded eight methylated flavonoids; 5-hydroxy-3, 4′,7-trimethoxyflavone (1), 3,5-dihydroxy-4′,7-dimethoxyflavone (2), santin (3), kumatakenin (4), rhamnocitrin (5), isokaempferide (6), 3,4′,5,7, tetrahydroxy-6-methoxyflavone (7), pinocembrin (8); two clerodanes, dodonic acid (9) and 2β-hydroxyhardwickiic acid (10) and one labdane; (ent-3β,8α)-15,16-epoxy-13(16),14-labdadiene-3,8-diol (11) diterpenoids. The flavonoid aglycones; 6, 7 and the clerodane diterpenoids; 9 and 10 and labdane diterpenoid, 11 were isolated for the first time from this plant species. The structures of the isolated compounds were identified using ultraviolet (UV), mass spectroscopy (MS), one dimension (1D) and two dimension (2D) nuclear magnetic resonance (NMR) spectroscopy and by comparison of the spectral data with literature. The quercetin derivative, 3,4′,5-trihydroxy-3′,7-dimethoxyflavone (12) showed broad spectrum antibacterial activities against E. coli and B. pumilus with minimum inhibition concentration (MIC) values less than 31.25 μg/well and against S. aureus with MIC below 62.5 μg/well. This compound showed poor antifungal activity against S. cerevisiae (MIC < 500 μg/well). Good antifungal activities were observed for 5,4′-dihydroxy-7-methoxyflavanone (13) and hautriwaic acid lactone (14) against S. cerevisiae with MIC values less than 7.8 μg/well. The most active antifungal compound was 5,7-dihydro-3,4′,6-trimethoxyflavone (3, santin) with an MIC value less than 3.9 μg/well against S. cerevisiae. The rest of the compounds exhibited weak to moderate activities. For comprehensive structure activity relationship studies (SAR), hautriwaic acid lactone (14), hautriwaic acid (15), penduletin (16) isolated from the surface exudates of D. angustifolia from Voi (200 km from Mombasa city center, Kenya) and 12 and 13 from Senecio roseiflorus isolated earlier were included in the bioassays.

Yenesew A. "Antimicrobial flavonoids from the stem bark of Erythrina burttii." Fitotherapia . 2005;76:469-472. Abstractpaper_38_yenesew_et_al_fito_2005_76_469.pdf

The chloroform extract of the stem bark of Erythrina burttii showed antifungal and antibacterial activities using the disk diffusion method. Flavonoids were identified as the active principles. Activities were observed against fungi and Gram(+) bacteria, but the Gram() bacteria Escherichia coli was resistant.

Nguta JM, Appiah-Opong R, Nyarko AK, Yeboah-Manu, D., Addo GA, Otchere, I., Kissi-Twum A. "Antimycobacterial and cytotoxic activity of selected medicinal plant extracts." Journal of Ethnopharmacology. 2016;182, :10-15.
Kama-Kama F, Omosa LK, Nganga J, Maina N, Osanjo G, Yaouba S, Ilias M, Midiwo J, Naessens J. "Antimycoplasmal Activities of Compounds from Solanum aculeastrum and Piliostigma thonningii against Strains from the Mycoplasma mycoides Cluster." Frontiers in Pharmacology. 2017;9:920.
Kama-Kama F, Omosa LK, Nganga J, Maina N, Osanjo G, Yaouba S, Ilias M, Midiwo J, Naessens J. "Antimycoplasmal Activities of Compounds from Solanum aculeastrum and Piliostigma thonningii against Strains from the Mycoplasma mycoides Cluster." Frontiers in pharmacology. 2017;8:920. Abstract

Infections caused by Mycoplasma species belonging to the ‘mycoides cluster’ negatively affect the agricultural sector through losses in livestock productivity. These Mycoplasma strains are resistant to many conventional antibiotics due to the total lack of cell wall. Therefore there is an urgent need to develop new antimicrobial agents from alternative sources such as medicinal plants to curb the resistance threat. Recent studies on extracts from Solanum aculeastrum and Piliostigma thonningii revealed interesting antimycoplasmal activities hence the motivation to investigate the antimycoplasmal activities of constituent compounds. The CH2Cl2/MeOH extracts from the berries of S. aculeastrum yielded a new β-sitosterol derivative (1) along with six known ones including; lupeol (2), two long-chain fatty alcohols namely undecyl alcohol (3) and lauryl alcohol (4); two long-chain fatty acids namely; myristic acid (5) and nervonic acid (6) as well as a glycosidic steroidal alkaloid; (25R)-3β-{O-α-L-rhamnopyranosyl-(1→2)-O-[α-L-rhamnopyranosyl-(1→4)]-β-D-glucopyranosyloxy-22α-N-spirosol-5-ene (7) from the MeOH extracts. A new furan diglycoside, (2,5-D-diglucopyranosyloxy-furan) (8) was also characterized from the CH2Cl2/MeOH extract of stem bark of P. thonningii. The structures of the compounds were determined on the basis of spectroscopic evidence and comparison with literature data. Compounds 1, 3, 4, 7 and 8 isolated in sufficient yields were tested against the growth of two Mycoplasma mycoides subsp. mycoides (Mmm), two M.mycoides. capri (Mmc) and one M. capricolum capricolum (Mcc) using broth dilution methods, while the minimum …

Kariuki1 HN, Kanui TI, Yenesew A, Patel N, Mbugua PM. "Antinociceptive and anti-inflammatory effects of Toddalia asiatica (L) Lam. (Rutaceae) root extract in Swiss albino mice." Pan African Medical journal. 2013;14( ):133.
Yenesew A. "Antinocieptive Activities of the Root Extracts of Rhus natalensis Kraus and Senna singueana." Phytopharmacology . 2012;2:1-6. Abstractpaper_59_karuki_et_al-2012.pdf

Rhus natalensis and Senna singuaenae are traditional African plants commonly used as medicinal plant in East Africa for the management of pain. The plants are used for management of rheumatism among others. This study investigated the antinociceptive activities of R. natalensis and S. singuaenae in Swiss albino mice using the tail-flick and hot plate tests. Extract solvent (vehicle), morphine and aspirin were employed as controls. Root extract of R. natalensis (100 and 200 mg /kg) and 100 mg /kg of S. singuaenae showed no significant antinociceptive activity in the hot plate while the 200mg /kg of S. singuaenae showed significant antinociceptive activity (p<0.05). In the tail flick tests, root extract of R. natalensis (100 and 200 mg / kg) showed highly significant antinociceptive activity (p<0.01) while 200mg / kg of S. singuaenae showed significant antinociceptive activity (p<0.05) compared to the controls. The 100 mg /kg of S. singuaenae showed no significant antinociceptive activity in the tail flick. This study lends support to the anecdotal evidence for use of R. natalensis and S. singuaenae in the management of painful conditions.

Keywords: Rhus natalensis; Senna singuaenae; analgesic; Rhus natalensis; Senna singuaenae; rheumatism

Kariuki HN;, Kanui TI;, Yenesew A;, Patel NB;, Mbugua PM. "Antinocieptive activity of Toddalia asiatica (L) Lam. in models of central and peripheral pain." Phytopharmacology. 2012;3(1):122-129.
Yenesew A. "Antinocieptive activity of Toddalia asiatica (L) Lam. in models of central and peripheral pain." Phytopharmacology . 2012;3(1):122-129. Abstractpaper_60_kariuki_et_al_phytopharmacology_2012.pdf

Toddalia asiatica within the context of traditional African medicine is a commonly used medicinal plant in East Africa for the management of pain and inflammatory conditions. It is used by the Masai in both Kenya and Tanzania for management of rheumatism among others. The present study was undertaken to investigate the antinociceptive activities of T. asiatica in Swiss albino mice in acetic acid-induced writhing, tail-flick and hot plate pain tests. The extract solvent (vehicle), morphine and aspirin were employed as negative and positive controls respectively. The acetic acid -induced writhing test was used as the screening test and as the root bark extract was found to be more potent than the leaf extract, the former was investigated using the hot plate and the tail flick tests. The root bark extract (200 mg / kg) showed highly significant (p < 0.001) antinociceptive activity in the hot plate and the tail flick tests. The 100mg/kg dose showed significant (p < 0.05) activity in the tail flick test but not significant in the hot plate test. The present study, therefore lends support to the anecdotal evidence for use of T. asiatica in the management of painful conditions.

Yenesew A, KARIUKI HELLENN, Patel NB, Mbugua PM, Kanui TI. "Antinocieptive activity of Toddalia asiatica (L) Lam. in models of central and peripheral pain.". 2012.
Machumi F, Yenesew A, Midiwo JO, Heydenreich M, Kleinpeter E, Khan S, Tekwani BL, Walker LA, Muhammad I. "Antiparasitic and anticancer carvotacetone derivatives from Sphaeranthus bullatus.". 2012.Website
Yenesew A. "Antiplasmodial activities and X-ray crystal structures of rotenoids from the stem bark of Millettia usaramensis subspecies usaramensis." Phytochemistry. 2003;64:773-779. Abstractpaper_34_yenesew_et_al_phyto_2003_64_773.pdf

The dichloromethane extract of the stem bark of Millettia usaramensis subspecies usaramensis showed anti-plasmodial activity against the chloroquine sensitive (D6) and chloroquine resistant (W2) strains of Plasmodium falciparum. Chromatographic separation of the extract led to the identification of a new rotenoid, (6aR,12aS)-2,3-methylenedioxy-9-methoxy-8-(3,3-dimethylallyl)-12ahydroxyrotenoid (trivial name, usararotenoid C) along with known flavonoids (usararotenoid A, 12a-epimillettosin, 6a,12a-dehydromillettone, barbigerone and 40-O-geranylisoliquiritigenin) as the anti-plasmodial principles. The structures were determined by spectroscopic analyses. CD and X-ray analyses established absolute configurations.

Irungu BN, Adipo N, Orwa JA, Kimani F, Heydenreich M, Midiwo JO, Björemark PM, Håkansson M, Yenesew A, Erdélyi Máté. "Antiplasmodial and cytotoxic activities of the constituents of Turraea robusta and Turraea nilotica." Journal of Ethnopharmacology. 2015;174:419-425. AbstractJournal Article

Ethnopharmacological relevance
Turraea robusta and Turraea nilotica are African medicinal plants used for the treatment of a wide variety of diseases, including malaria. The genus Turraea is rich in limonoids and other triterpenoids known to possess various biological activities.

Yenesew A. "Antiplasmodial and larvicidal activities of flavonoids of Derris trifoliata." Bull. Chem. Soc. Ethiopia . 2009;23:409-414. Abstractpaper_48_yenesew_et_al_bull_chem_soc_ethiop-2009-23-409.pdf

From the dichloromethane-methanol (1:1) extract of the seed pods of Derris trifoliata, a new flavanone derivative (S)-lupinifolin 4´-methyl ether was isolated. In addition, the known flavonoids lupinifolin
and rotenone were identified. The structures were determined on the basis of spectroscopic evidence. Lupinfolin showed moderate in vitro antiplasmodial activity against the D6 (chloroquine-sensitive) and W2 (chloroquineresistant) strains of Plasmodium falciparum. The different parts of this plant showed larvicidal activities against Aedes aegypti and rotenoids were identified as the active principles.

KEY WORDS: Derris trifoliata, Leguminosae, Flavanone, (S)-Lupinifolin 4´-methyl ether, Lupinifolin,
Antiplasmodial, Rotenoid, Larvicide, Aedes aegypti

Yenesew A, Twinomuhwezi H, Kabaru JM, Akala HM, Kiremire BT, Heydenreich M, Peter. "Antiplasmodial and larvicidal flavonoids from Derris trifoliata.". 2009.Website
Yenesew A, Twinomuhwezi H, Kabaru JM, Akala HM, Kirimire B, Heydenreich M, Peters MG, Eyase FL, Waters NC, Walsh DS. "Antiplasmodial and larvicidal flavonoids from Derris trifoliata." Bull. Chem. Soc. Ethiop. 2009;23(3):001-006.
Yenesew A. "The Antiplasmodial and Radical Scavenging Activities of Flavonoids of Erythrina burttii." Acta Tropica . 2012;123:123-127. Abstract

The acetone extract of the root bark of Erythrina burttii showed in vitro antiplasmodial activity against
the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum with
IC50 values of 0.97 ± 0.2 and 1.73 ± 0.5 g/ml respectively. The extract also had radical scavenging activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical with an EC50 value of 12.0 g/ml. The isoflav-3-enes burttinol-A and burttinol-C, and the 2-arylbenzofuran derivative burttinol-D were identified as the most active antiplasmodial (IC50 < 10 M) and free radical scavenging (EC50 ca. 10 M) principles. The acetone extract of E. burttii at 800 mg/kg/day, in a 4-day Plasmodium berghei ANKA suppressive test, showed in vivo antimalarial activity with 52% hemosuppression. In the same in vivo test, marginal activities were also
observed for the extracts of the root and stem bark of Erythrina abyssinica and the root bark of Erythrina
sacleuxii.

Yenesew A. "Antiplasmodial b-hydroxydihydrochalcone from seedpods of Tephrosia elata." Phytochemistry Letters . 2009;2:99-102. Abstractpaper_46_muiva_et_al_phytol-2009.pdf

From the seedpods of Tephrosia elata, a new b-hydroxydihydrochalcone named (S)-elatadihydrochalcone
was isolated. In addition, the known flavonoids obovatachalcone, obovatin, obovatin methyl ether
and deguelin were identified. The structures were determined on the basis of spectroscopic evidence.
The crude extract and the flavonoids obtained from the seedpods of this plant showed antiplasmodial
activities. The literature NMR data on b-hydroxydihydrochalcones is reviewed and the identity of some
of the compounds assigned b-hydroxydihydrochalcone skeleton is questioned.

Andayi AW, Yenesew A, Derese S, Midiwo JO, Gitu PM, Jondiko OJI, Akala H, Liyala P. "Antiplasmodial Flavonoids from Erythrina sacleuxii.". 2006.Website
Andayi AW, Yenesew A, Derese S, Midiwo JO, Gitu PM, Jondiko OJI, Akala H, Liyala P. "Antiplasmodial Flavonoids from Erythrina sacleuxii.". 2006.Website
Muiva-Mutisya LM, Atilaw Y, Heydenreich M, Koch A, Akala HM, Cheruiyot AC, Brown ML, Irungu B, Okalebo FA, Derese S, Mutai C, Yenesew A. "Antiplasmodial prenylated flavanonols from Tephrosia subtriflora." Natural product research. 2018;32(12):1407-1414. AbstractJournal article

Abstract
The CH2Cl2/MeOH (1:1) extract of the aerial parts of Tephrosia subtriflora afforded a new flavanonol, named subtriflavanonol (1), along with the known flavanone spinoflavanone B, and the known flavanonols MS-II (2) and mundulinol. The structures were elucidated by the use of NMR spectroscopy and mass spectrometry. The absolute configuration of the flavanonols was determined based on quantum chemical ECD calculations. In the antiplasmodial assay, compound 2 showed the highest activity against chloroquine-sensitive Plasmodium falciparum reference clones (D6 and 3D7), artemisinin-sensitive isolate (F32-TEM) as well as field isolate (KSM 009) with IC50 values 1.4–4.6 μM without significant cytotoxicity against Vero and HEp2 cell lines (IC50 > 100 μM). The new compound (1) showed weak antiplasmodial activity, IC50 12.5–24.2 μM, but also showed selective anticancer activity against HEp2 cell line (CC50 16.9 μM).

Keywords: Tephrosia subtriflora, Leguminosae, prenylated flavanonol, subtriflavanonol, antiplasmodial, cytotoxicity

Endale M, Alao JP, Akala HM, Rono NK, Eyase FL, Solomon D, Ndakala A, Mbugua M, Walsh DS, Erdelyl M, Yenesew A. "Antiplasmodial Quinones from Pentas longiflora and Pentas lanceolata." Planta Medica . 2012;78(1):31-35.
Yenesew A., Endale, M. AAREDNMWSJPHM. "Antiplasmodial Quinones from Pentas longiflora and Pentas lanceolata." Planta medica . 2012;78:31-35. Abstractpaper_53_endale_et_al_planta_medica_2012-78-31-35.pdf

The dichloromethane/methanol (1 : 1) extracts of the roots of PENTAS LONGIFLORA and PENTAS LANCEOLATA showed low micromolar (IC (50) = 0.9-3 µg/mL) IN VITRO antiplasmodial activity against chloroquine-resistant (W2) and chloroquine-sensitive (D6) strains of PLASMODIUM FALCIPARUM. Chromatographic separation of the extract of PENTAS LONGIFLORA led to the isolation of the pyranonaphthoquinones pentalongin ( 1) and psychorubrin ( 2) with IC (50) values below 1 µg/mL and the naphthalene derivative mollugin ( 3), which showed marginal activity. Similar treatment of PENTAS LANCEOLATA led to the isolation of eight anthraquinones ( 4-11, IC (50) = 5-31 µg/mL) of which one is new (5,6-dihydroxydamnacanthol, 11), while three - nordamnacanthal ( 7), lucidin- ω-methyl ether ( 9), and damnacanthol ( 10) - are reported here for the first time from the genus PENTAS. The compounds were identified by NMR and mass spectroscopic techniques.

Yenesew A., Martha Induli, Meron Gebru NAHAIWRBMHSM. "Antiplasmodial Quinones from the Rhizomes of Kniphofia foliosa." Natural Products Comunications . 2013;8:1261-1264. Abstractpaper_64_induli_et_al-npc-2013.pdf

Extracts of the rhizomes of Kniphofia foliosa exhibited antiplasmodial activities against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum with IC50 values of 3-5 microg/mL. A phenyloxanthrone, named 10-acetonylknipholone cyclooxanthrone (1) and an anthraquinone-anthrone dimer, chryslandicin 10-methyl ether (2), were isolated from the rhizomes, along with known quinones, including the rare phenylanthraquinone dimers, joziknipholones A and B. The structures of these compounds were determined based on spectroscopic data. This is the second report on the occurrence of the dimeric phenylanthraquinones in nature. In an in vitro antiplasmodial assay of the isolated compounds, activity was observed for phenylanthraquinones, anthraquinone-anthrone dimers and dimeric phenylanthraquinones, with joziknipholone A being the most active. The new compound, 10-acetonylknipholone cyclooxanthrone, also showed anti-plasmodial activity. In an in vivo assay, knipholone anthrone displayed marginal antimalarial activity.

Muthaura CN, Keriko JM, Mutai C, Yenesew A, Heydenreich M, Atilaw Y, Gathirwa JW, Irungu BN, Derese S. "Antiplasmodial, Cytotoxicity and Phytochemical Constituents of Four Maytenus Species Used in Traditional Medicine in Kenya." The Natural Products Journal. 2017;7(2):144-152.
Muthaura CN, Keriko JM, Mutai C, Yenesew A, Heydenreich M, Atilaw Y, Gathirwa JW, Irungu BN, Derese S. "Antiplasmodial, Cytotoxicity and Phytochemical Constituents of Four Maytenus Species Used in Traditional Medicine in Kenya." The Natural Products Journal. 2017;7(2):144-152. AbstractJournal article

Description
Background:
In Kenya, several species of the genus Maytenus are used in traditional medicine to treat many diseases including malaria. In this study, phytochemical constituents and extracts of Maytenus undata, M. putterlickioides, M. senegalensis and M. heterophylla were evaluated to determine compound/s responsible for antimalarial activity.
Objective:
To isolate antiplasmodial compounds from these plant species which could be used marker compounds in the standardization of their extracts as a phytomedicine for malaria.
Methods:
Constituents were isolated through activity-guided fractionation of the MeOH/CHCl3 (1:1) extracts and in vitro inhibition of Plasmodium falciparum. Cytotoxicity was evaluated using Vero cells and the compounds were elucidated on the basis of NMR spectroscopy.
Results:
Fractionation of the extracts resulted in the isolation of ten known compounds. Compound 1 showed …
Total citations
Cited by 1
2018
Scholar articles
Antiplasmodial, Cytotoxicity and Phytochemical Constituents of Four Maytenus Species Used in Traditional Medicine in Kenya
CN Muthaura, JM Keriko, C Mutai, A Yenesew… - The Natural Products Journal, 2017
Cited by 1 Related articles

Andima M, Coghi P, Yang LJ, Wong VKW, Ngule CM, Heydenreich M, Ndakala AJ, Yenesew A, Derese S. "Antiproliferative Activity of Secondary Metabolites from Zanthoxylum zanthoxyloides Lam: In vitro and in silico Studies." Pharmacognosy Communications. 2020;10(1). AbstractPharmacognosy Communications

Description
Background: Plant derived compounds have provided proming leads in search for safer anticancer chemotherapies. Zanthoxylum zanthoxyloides is a common medicinal plant in Uganda whose bioactive composition has not been fully elucidated. The aim of this study was to evaluate the in vitro antiproliferative potential of compounds isolated from Zanthoxylum zanthoxyloides and their probable in silico anticancer mechanisms of action. Methods: Column chromatography was used to isolate compounds from MeOH: CH2Cl2 (1: 1) extract of the stem bark extract of Zanthoxylum zanthoxyloides. The structures of the isolated compounds were elucidated by NMR and MS analyses. MTT assay was used to measure cell viability. Using in silico docking, the interaction of the compounds with key target proteins in the p53 pathway was determined. Results: From the root bark of this plant five compounds were isolated, namely; dihydrochelerythrine (1), skimmianine (2), tridecan-2-one (3), sesamin (4) and hesperidin (5). Dihydrochelerythrine (1) inhibited proliferation of liver cancer (HCC) cells (IC50 21.2), breast cancer (BT549) cells,(IC50 21.2 μM). Similarly, sesamin (4) exhibited moderate inhibitory activity against BT549 cancer cells (IC50 47.6 μM). Hesperidin (5) showed low inhibitory activity against A549 and HEp2 (Larynx) cells but was significantly toxic to normal liver and lung cells.
In silico docking studies showed that all the compounds strongly bind to cyclin-dependent kinases (CDK2 and CDK6) and weakly bind to caspases 3 and 8 suggesting that they inhibit cancer cells by inducing cell cycle arrest and apoptosis. Conclusion: This study indicates …

Yenesew A., and N. Mascolo, A. Pinto DE. "Antipyretic and analgesic studies of the ethanolic extract of Teclea nobilis Delile." Phytotherapy Research. 1988; 2:154-156. Abstractpaper_6_mascolo_et_al_phytotherapy_1988.pdf

The crude ethanol extract of the leaves of an African medicinal plant Teclea nobilis has been studied for its antipyretic, analgesic and anti-inflammatory activities. The extract exhibited marked antipyretic and analgesic activities while it was found to be weakly active against carrageenin oedema.

Gitu P, Yusuf A, Ogutu V. "Application of tetralinyl group in solid-phase peptide synthesis." Int. J. BioChemiPhysics. 1998;6,7(1,2):7-10.scan0055.pdf
BHALENDU PROFBHATT, YUSUF DROKEYOAMIR. "Application of tetralinyl group in solid-phase peptide, synthesis.". In: International Journal of Biochemisphysics vol. 6 & 7, Nos (1&2), 7 - 10. B.M. Bhatt and P.M. Gitu; 1998. Abstract
We surveyed the phytoseid mites in four different geographical zones of Kenya: Zone I, upper highland and tropical alpine (2400-4400m): Zone II, lower highland (1800-2400m); zone III, midland (800-1800m); Zone IV, tropical, hot and humid( 0-800m ). A total of 107 species was found. In the sub family, amblyseeinae there were 14 species in the genus Neoseilus , one in Aspereroseius Chant, one in Paraphytoseius Swirski &Schechter, five in typhlodromips De Leon, five in Transeius Chant & McMurty, one in Graminaseius Chant &McMurty, 11 in Amblyseius Berlese, one in Arrenoseius Wanstein, two in Typhlodromalus muma, seven in Ueckemannseius Chant &McMurty, one in Ambylodromalus Chant &Mcmurty,, 20 in Euseius Wanstein, one in Iphiseius Berlese, one in Phytoseilus Evans and one in Gynaseius Ehara & Imano. In the subfamily Phytoseiinae Berlese there were four species in the genus Phytoseiius Ribaga. In the subfamily Typhlodrominae Wanstein, there were four species in the genus Kuzinellus Wainstein and 27 in Typhlodromus Scheuten
Gitu PM, Yusuf A, Bhatt BM. "Application of tetralinyls as carboxamide protecting groups in peptide synthesis." Bulletin of the Chemical Society of Ethiopia. 1998;12(1):35-43.bcse_12_1_1998.pdf
Birgen J, Wafula G, Yusuf A, Onyatta J. "Assessment of Sulphur Dioxide Levels in Selected Sites in Athi River, Kenya." International Journal of Trend in Scientific Research and Development (IJTSRD). 2017;1(5):416-422.
Birgen J, Yusuf AO, Wafula G, Onyatta JO. "Assessment of sulphur dioxide levels in selected sites in Athi River, Kenya." International Journal of Trend in Scientific Research and Development. 2017;1(5):416-422.scan_trend.pdf
Yadav G, Saskin R, Ngugi E, Kimani J, Keli F, Fonck K, MacDonald KS, Bwayo JJ, Temmerman M, Moses S, others. "Associations of sexual risk taking among Kenyan female sex workers after enrollment in an HIV-1 prevention trial." JAIDS Journal of Acquired Immune Deficiency Syndromes. 2005;38:329-334. Abstract
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Bose S, Yap L-F, Fung M, Starzcynski J, Saleh A, Morgan S, Dawson C, Chukwuma MB, Maina E, Buettner M, Wei W, Arrand J, Lim PVH, Young LS, Teo SH, Stankovic T, Woodman CBJ, Murray PG. "The ATM tumour suppressor gene is down-regulated in EBV-associated nasopharyngeal carcinoma." J. Pathol.. 2009;217(3):345-52. Abstract

A micro-array analysis using biopsies from patients with EBV-positive undifferentiated nasopharyngeal carcinoma (NPC) and from cancer-free controls revealed down-regulation of tumour suppressor genes (TSG) not previously associated with this disease; one such gene was the ataxia telangiectasia mutated (ATM) gene. Q-PCR confirmed down-regulation of ATM mRNA and ATM protein expression in tumour cells was weak or absent in almost all cases. In NPC cell lines, however, ATM was down-regulated only in the EBV-positive line, C666.1, and in none of five EBV-negative lines. In vitro infection of EBV-negative NPC cell lines with a recombinant EBV was followed by the down-regulation of ATM mRNA and protein, and only EBV-positive cells showed a defective DNA damage response following gamma-irradiation. Our data suggest that loss of ATM function could be an important step in the pathogenesis of NPC, and may have implications for the treatment of this disease.

Ooko J, Onyatta JO, Yusuf AO. "Atmospheric corrosion studies in Kenya. Past, present and future." African Corrosion Journal. 2016;2(1):25-32.afr_cor_j_corrosion.pdf
Onyatta JO, Yusuf AO, Ooko JO. "Atmospheric Corrosion Studies in Kenya: Past, Present and Future." African Corrosion Journal. 2016;2(1):25-31.
B
Faktorovich EG, Steinberg RH, Yasumura D, Matthes MT, LaVail MM. "Basic fibroblast growth factor and local injury protect photoreceptors from light damage in the rat." The Journal of neuroscience: the official journal of the Society for Neuroscience. 1992;12:3554-3567. Abstract

Injection of basic fibroblast growth factor (bFGF) into the eye, intravitreally or subretinally, delays photoreceptor degeneration in inherited retinal dystrophy in the rat, as does local injury to the retina (Faktorovich et al., 1990). To determine whether this heparin-binding peptide or local injury is effective in any other form of photoreceptor degeneration, we examined their protective roles in light damage. Albino rats of the F344 strain were exposed to 1 or 2 weeks of constant fluorescent light (115-200 footcandles), either with or without 1 microliter of bFGF solution (1150 ng/microliters in PBS) injected intravitreally or subretinally 2 d before the start of light exposure. Uninjected and intravitreally PBS-injected controls showed the loss of a majority of photoreceptor nuclei and the loss of most inner and outer segments after 1 week of light exposure, while intravitreal injection of bFGF resulted in significant photoreceptor rescue. The outer nuclear layer in bFGF-injected eyes was two to three times thicker than in controls, and the inner and outer segments showed a much greater degree of integrity. Following recovery in cyclic light for 10 d after 1 week of constant light exposure, bFGF-injected eyes showed much greater regeneration of photoreceptor inner and outer segments than did the controls. bFGF also increased the incidence of presumptive macrophages, located predominantly in the inner retina, but the evidence suggests they are not directly involved in photoreceptor rescue. Subretinal injection of bFGF resulted in photoreceptor rescue throughout most of the superior hemisphere in which the injection was made, with rescue extending into the inferior hemisphere in many of the eyes. Remarkably, the insertion of a dry needle or injection of PBS into the subretinal space also resulted in widespread photoreceptor rescue, extending through 70% or more of the superior hemisphere, and sometimes into the inferior hemispheres. This implicates the release and widespread diffusion of some endogenous survival-promoting factor from the site of injury in the retina. Our findings indicate that the photoreceptor rescue activity of bFGF is not restricted to inherited retinal dystrophy in the rat, and that light damage is an excellent model for studying the cellular site(s), kinetics, and molecular mechanisms of both the normal function of bFGF and its survival-promoting activity. Moreover, the injury-related rescue suggests that survival-promoting factors are readily available to provide a protective role in case of injury to the retina, presumably comparable to those that mediate the "conditioning lesion" effect in other neuronal systems.

Yenesew A. "Bioactive compounds from some Kenyan ethnomedicinal plants: Myrsinaceae, Polygonaceae and Psiadia punctulata." Phytochemical Reviews . 2002;1:311-323. Abstractpaper_29_midiwo_et_al_phytochemical_rev_2002.pdf

here are several described medicinal plants in Kenya from a flora of approximately 10,000 members. Strong cross-medical information from the 42 ethnic groups points to the high potential of some of these species. The Myrsinaceae are well established ethno-anthelmintics and anti-bacterials. They are harbingers of long alkyl side chain benzoquinones which clearly have a protective function from their histochemical disposition. The main benzoquinone in the sub-family Myrsinodae is embelin while for the Maesodae it is maesaquinone together with its 5-acetyl derivative; the distribution of these benzoquinones by their alkyl side chain length or the presence/absence of a 6-methyl group is in accord with morphological sub-family de-limitation. The benzoquinones showed anti-feedant, anti-microbial, phytotoxic, acaricidal, insecticidal and nematicidal activity. Many other benzoquinones of medium and minor concentration were also isolated and characterised. Some plants belonging to the Polygonaceae which are widely used as ethno-anthelmintics have been studied. The common anthelmintic anthraquinones were obtained from all five Rumex species while the naphthalenic acetogenin derivative, nepodin was more selectively distributed. The leaf of Polygonum senegalense is up to 17% surface exudate; about thirteen non polar flavonoid derivatives (chalcones, dihydrochalcones, flavanones and a flavone) have been isolated from it. From the internal aerial tissues of this plant, the major flavonoids were common flavonoids, quercetin, kaempferol, luteolin and their glycosides. The only unique compound isolated from this plant was 2′-glucosyl-6′-hydroxy-4′-methoxydihydrochalcone whose aglycone, uvangolatin is part of the exudate mixture. Other leaf exudate plants studied include the stomach-ache medicine, Psiadia punctulata (Compositae) from which novel methylated flavonoids, kaurene and trachyloban diterpenes have been found.

Osebe T, Mbaria J, Yole D, Odongo D, Nderitu J, Ochanda H. "Bioactivity and toxicity of Bridelia micrantha, Chenopodium ambrosoides and Ocimum americanum plant extracts." International Journal of Basic & Clinical Pharmacology. 2016;6(1):5-11. AbstractWebsite

Background: Bridelia micrantha, Chenopodium ambrosoides and Ocimum
americanum plant species are commonly used in traditional medicine for a
number of ailments. The extracts of these plants have been shown to have antischistosomal
activity suggesting that they could be used for the development of
new chemical entities (NCEs) for the treatment of schistosomiasis. However
there is limited knowledge on their toxicological profile and their use in
traditional medicine may not be a satisfactory safety indication.
Methods: In this study the extracts were first screened for bioactivity using
brine shrimp lethality test for the determination of LC50 followed by rodent
acute toxicity and 28 day subchronic studies.
Results: B. micrantha water extract with a LC50 of 77µg/ml was deemed toxic
while C. ambrosoides methanol and water extracts were moderately toxic with
LC50 of 104.63µg/ml and 696.44µg/ml respectively. O. americanum hexane
and water extracts toxicity varied from moderate to slightly toxic with LC50 of
887.59µg/ml and 2254.60µg/ml respectively. C. ambrosoides and O.
americanum water extracts which were preferentially selected for subsequent
studies were found to have mild to no irritation to rodent eyes and skin.
Moreover, the aminotransferases AST and ALT which were used to detect liver
injury suggested negligible effect.
Conclusions: This therefore confirms that C. ambrosoides and O. americanum
water extracts are safe for clinical use with O. americanum water extract having
a slight edge.
Keywords: Antihelminthic, Schistosomiasis, Toxicity

Yenesew A, Gumuia I, Heydenreich M, Derese S, Okalebo FA, Ndiege IO, Erdelyi M. "Bioactivity of 'Flemingin A' and other Natural Products from the leaves of Flemingia grahamiana.". 2011.yenesew.pdfWebsite
Young AS, Ochanda H, Perry BD, Morzaria SP, Dolan TT, Medley GF, Gettinby G. The biology of the transmission dynamics of Theileria parva. . Nairobi, Kenya: International Society for Veterinary Epidemiology and Economics.; 1994.
Yenesew A. "Busseihydroquinones A-D from the Roots of Pentas bussei." Journal of Natural Products. 2012;75 :1299-1304. Abstractpaper_57_endale_et_al_j_nat_prod_2012.pdf

Four new naphthohydroquinones, named busseihydroquinones A−D (1−4), along with a known homoprenylated dihydronaphthoquinone (5), were isolated from the CH2Cl2/MeOH (1:1) extract of the roots of Pentas bussei. Although the genus Pentas is frequently used by traditional healers for the treatment of malaria, only marginal activities against the chloroquine-sensitive (D6) and the chloroquineresistant (W2) strains of Plasmodium falciparum were observed for the crude root extract and the isolated constituents of this plant.

C
Yenesew A. "C-Methylated and C-prenylated isoflavonoids from root extracts of Desmodium uncinatum." Phytochemistry 68, 646-651.. 2007;68(5):646-651. Abstractpaper_44_guchu_et_al_phyto_2007_68_646.pdf

A pterocarpan, 1,9-dihydroxy-3-methoxy-2-methylpterocarpan (named uncinacarpan) and two isoflavanones, 5,7-dihydroxy-2',3',4'-trimethoxy-6-(3-methylbut-2-enyl)isoflavanone (named uncinanone D) and ,4'-dihydroxy-7,2'-dimethoxy-6-methylisoflavanone (named uncinanone E), were isolated from the CH(2)Cl(2) root extract of Desmodium uncinatum (Jacq.) DC and characterised by spectroscopic methods. In addition, a rare pterocarpan edudiol and two known abietane diterpenes, 7-oxo-15-hydroxydehydroabietic acid and 7-hydroxycallitrisic acid were identified. The fraction of the root extract that was analysed induced germination of Striga hermonthica seeds, but none of the isolated compounds showed this activity.

YUKO- DRJOWICHRISTINEA, E DRSIMIYUMAJORD. "C. Yuko-Jowi, DE Simiyu, RN Musoke : Ectopia cordis : a report of two cases East Afr Med J 81:486-498; 2004.". In: a report of two cases East Afr Med J 81:486-498; 2004. uon press; 2004. Abstract
Department of Paediatrics and Child Health, College of Health Sciences, University of Nairobi, P.O. Box 19676-00202 Nairobi, Kenya. OBJECTIVE: To describe the echocardiographic features of children with rheumatic heart disease seen at the Kenyatta National Hospital. DESIGN: A retrospective study. SETTING: The Kenyatta National Hospital Heart Unit. SUBJECTS: Patients aged 20 years and less with echocardiographic diagnosis of rheumatic heart disease. RESULTS: Two hundred and twenty four echocardiograms were analysed. Seventy six point four of cases were aged between 5 and 15 years, while on 3% were less than five years. The combinations mitral and aortic regurgitation was the most common lesion followed by isolated mitral regurgitation. Isolated aortic regurgitation was as rare as isolated mitral stenosis in the paediatric age group 1.8% and 2.7% respectively. When seen in the younger age group, the leaflet morphology in mitral regurgitation was predominantly thickening and clubbing of the leaflets while in the older children the pathology was of marked fibrosis of the sub-valvular apparatus. Leaflet prolapse and commissural fusion was the major pathology in aortic regurgitation. Pulmonary hypertension was the most common complication commonly seen in mitral valve disease. Calcification was a rare encounter in this age bracket. CONCLUSIONS: Rheumatic heart disease in the paediatric age commonly presents as isolated mitral regurgitation or in combinations of mitral and aortic regurgitation. The complications of pulmonary hypertension was predominant in mitral valve disease. Valvular calcification is rare in juvenile rheumatic heart disease. PMID: 16450679 [PubMed - indexed for MEDLINE]
Yoshimura F, Suzuki T. "Calcium-stimulated adenosine triphosphatase in the microsomal fraction of tooth germ from porcine fetus." Biochim. Biophys. Acta. 1975;410(1):167-77. Abstract

The characterization and localization of a Ca(2+)-ATPase (ATP phosphohydrolase, EC 3.6.1.3) in the tooth germ of the porcine fetus are reported. This enzyme, a microsome fraction, is preferentially activated by Ca(2+). In the presence of 0.5 mM ATP, maximal enzyme activity is obtained at 0.5--1.0 mM CaCl2. The maximal rate of ATP hydrolysis is approx. 20 mumol per h per mg of protein as the enzyme preparation is used here. At optimal Ca(2+) concentration, the Mg(2+) has an inhibitory effect. The enzyme does not require Na+ or/and K+ for activation by Ca(2+). Other nucleotide triphosphates may serve as the substrate, but V for ATP is the highest. The Km for ATP is 8.85 - 10(-5) M. The optimal pH for Ca(2+) activation of the enzyme lies around 9.2. Well known inhibitors of (Na+ + K+)-ATPase, mitochondria ATPase and Ca(2+)-ATPase in the erthrocyte do not inhibit the enzyme. In the subcellular order the enzyme may be assumed to be localized in the smooth endoplasmic reticulum fraction containing cell and Golgi body membrane fragments and in the tissue order in the enamel organ containing an ameloblast layer, stratum intermedium and stellate reticulum.

Sanchez JL, Johns MC, Burke RL, Vest KG, Fukuda MM, Yoon IK, Lon C, Quintana M, Schnabel DC, Pimentel G, Mansour M, Tobias S, Montgomery JM, Gray GC, Saylors K, Ndip LM, Lewis S, Blair PJ, Sjoberg PA, Kuschner RA, Russell KL, Blazes DL, Witt CJ, Money NN, Gaydos JC, Pavlin JA, Gibbons RV, Jarman RG, Stoner M, Shrestha SK, Owens AB, Iioshi N, Osuna MA, Martin SK, Gordon SW, Bulimo WD, Waitumbi DJ, Assefa B, Tjaden JA, Earhart KC, Kasper MR, Brice GT, Rogers WO, Kochel T, Laguna-Torres VA, Garcia J, Baker W, Wolfe N, Tamoufe U, Djoko CF, Fair JN, Akoachere JF, Feighner B, Hawksworth A, Myers CA, Courtney WG, Macintosh VA, Gibbons T, Macias EA, Grogl M, O'Neil MT, Lyons AG, Houng HS, Rueda L, Mattero A, Sekonde E, Sang R, Sang W, Palys TJ, Jerke KH, Millard M, Erima B, Mimbe D, Byarugaba D, Wabwire-Mangen F, Shiau D, Wells N, Bacon D, Misinzo G, Kulanga C, Haverkamp G, Kohi YM, Brown ML, Klein TA, Meyers M, Schoepp RJ, Norwood DA, Cooper MJ, Maza JP, Reeves WE, Guan J. "Capacity-building efforts by the AFHSC-GEIS program." BMC Public Health. 2011;11 Suppl 2:S4. AbstractWebsite

Capacity-building initiatives related to public health are defined as developing laboratory infrastructure, strengthening host-country disease surveillance initiatives, transferring technical expertise and training personnel. These initiatives represented a major piece of the Armed Forces Health Surveillance Center, Division of Global Emerging Infections Surveillance and Response System (AFHSC-GEIS) contributions to worldwide emerging infectious disease (EID) surveillance and response. Capacity-building initiatives were undertaken with over 80 local and regional Ministries of Health, Agriculture and Defense, as well as other government entities and institutions worldwide. The efforts supported at least 52 national influenza centers and other country-specific influenza, regional and U.S.-based EID reference laboratories (44 civilian, eight military) in 46 countries worldwide. Equally important, reference testing, laboratory infrastructure and equipment support was provided to over 500 field sites in 74 countries worldwide from October 2008 to September 2009. These activities allowed countries to better meet the milestones of implementation of the 2005 International Health Regulations and complemented many initiatives undertaken by other U.S. government agencies, such as the U.S. Department of Health and Human Services, the U.S. Agency for International Development and the U.S. Department of State.

Wamocho L;, Yamashita K;, Ishii, T; Michieka RW, Ishii, T; Michieka RW. "Charcoal Application and VAM Inoculation Promote Vine Growth, Yield and Quality of Passion Fruits in Kenya."; 2000. Abstract

A field experiment was conducted in 1996/1997 to investigate the effect of charcoal (CH) and vesicular-arbuscular mycorhiza (VAM) inoculation on vine growth, fruit development and quality of passion fruits grown in the field. Plants grown in soils that are low (< 30 ppm) in P content, benefited from root colonisation by VAM. Inoculation of passion fruit cuttings raised in sterilised media inoculated with VAM fungi significantly increased vine growth, yield and quality of fruit. Inoculation with VAM fungi resulted to 100% survival of passion fruit transplants

Yenesew A., and E. Dagne WAIGPG. "The Chemical Systematics of the Rutaceae, Subfamily Toddalioideae in Africa." Biochemical Systematics and Ecology . 1988;16:179-188. Abstractpaper_4_dagne_et_al__biochemical_sys_eco..1988.pdf

A recent investigation of five Ethiopian species of the Rutaceae subfamily Toddalioideae, Teclea nobilis, T. simplicifolia, T. borenensis, Vepris dainellii and V. glomerata has led to the identification of alkaloids of the 2-quinolone, dihydrofuroquinoline, linear pyranoquinoline, furoquinoline and acridone types. The distribution of alkaloids and limonoids among African genera of the Toddalioideae is discussed in relation to their potential importance for an understanding of the systematics of this group of species.

Yenesew A., van B-E. WADE. "Chemotaxonomic significance of anthraquinones in the roots of Asphodeloideae (Aspholdelaceae)." Biochemical Systematics and Ecology. 1995; 23: 277-281. Abstractpaper_18_van_wyk_et_al_biochemical_sys_eco_1995_23_277.pdf

The distribution of seven anthraquinones in the roots of some 46 species belonging to the genera Asphodelus, Asphodeline, Bulbine, Bulbinella and Kniphofia was studied by TLC and HPLC, 1,8-Dihydroxyanthraquinones based on a chrysophanol unit are the main constituents of the subterranean metabolism in the subfamily Asphodeloideae. The genera Bulbine, Bulbinella and Kniphofia elaborate knipholone-type compounds. These compounds appear to be characteristic constituents for the three genera Bulbine, Bulbinella and Kniphofia and support the idea that Kniphofia is not related to the Alooideae.

Yenesew., B-E., van Wyk DE. "Chemotaxonomic significance of root anthraquinones and pre-anthraquinones in the genus Lomatophyllum (Asphodelacae)." Biochemical Systematics and Ecology. 1995;23 :805-808. Abstractpaper_19_van_wyk_et_al_biochemical_sys_eco_1995_23_805.pdf

The roots of seven species of Lomatophyllum were analysed by TLC and HPLC for the presence of nine different anthraquinones and pre-anthraquinones which are all known to be characteristic constituents of the subterranean metabolism of Aloe. Chrysophanol and asphodelin were detected in all the samples analysed. In addition, the 1-methyl-8-hydroxyanthraquinones aloesaponarin I, aloesaponarin II and laccaic acid d-methyl ester, together with the corersponding pre-anthraquinones were detected in all seven species. The results support the inclusion of Lomatophyllum in Aloe.

Yenesew A., and B-E., van Wyk DE. "Chemotaxonomic survey of anthraquinones and pre-anthraquinones in roots of Aloe species." Biochemical Systematics and Ecology . 1995;23:267-275. Abstractpaper_17_van_wyk_et_al_biochemical_sys_eco_1995_23_267.pdf

Root samples from 172 species of Aloe were surveyed by TLC and HPLC for the presence of anthraquinones and pre-anthraquinones. With the exception of the three species of the series Serrulatae, 1,8-Dihydroxyanthraquinones (chrysophanol and asphodelin) were detected in all the species sampled. Compounds derived through the 1-methyl-8-hydroxyanthraquinone pathway, i.e. aloesaponarin I, aloesaponarin II and laccaic acid d-methyl ester, together with their corresponding pre-anthraquinones were detected in 129 species. The results also show that isoeleutherol is a useful chemotaxonomic character for the series Saponarieae.

Derese S, Yenesew A, Midiwo JO, Heydenreich, Peter MG. "The Chemotaxonomic Value Of Anthraquinones In Asphodelaceae.". 1994.Website
Davis SM, Pals S, Yang C, Odoyo-June E, Chang J, Walters MS, Jaoko W, Bock N, Westerman L, Toledo C, Bailey RC. "Circumcision status at HIV infection is not associated with plasma viral load in men: analysis of specimens from a randomized controlled trial." BMC Infect. Dis.. 2018;18(1):350. Abstract

Male circumcision provides men with approximately 60% protection from acquiring HIV infection via heterosexual sex, and has become a key component of HIV prevention efforts in sub-Saharan Africa. Possible mechanisms for this protection include removal of the inflammatory anaerobic sub-preputial environment and the high concentration of Langerhans cells on the inside of the foreskin, both believed to promote local vulnerability to HIV infection. In people who do acquire HIV, viral load is partially determined by infecting partner viral load, potentially mediated by size of infecting inoculum. By removing a portal for virion entry, prior male circumcision could decrease infecting inoculum and thus viral load in men who become HIV-infected, conferring the known associated benefits of slower progression to disease and decreased infectiousness.

Yanda P, Wandiga S, Kangalawe R, Opondo M, Olago D, Githeko A, Downs T, Robert Kabumbuli, Opere A, Githui F, Kathuri J, Olaka L, Apindi E, Marshall M, Ogallo L, Mugambi P, Kirumira E, Nanyunja R, Baguma T, Sigalla R, Achola P. "Climate, Malaria and Cholera in the Lake Victoria Region: Adapting to Changing Risks.". In: Climate Change and Adaptation. Routledge; 2012. Abstract

In the East African countries, malaria is ranked as the primary cause of morbidity and mortality in both children and adults. It causes about 40,000 infant deaths in Kenya each year; in Uganda annual cases of malaria range between 6 to 7 million, with 6500 to 8500 fatalities, and in Tanzania the annual death toll is between 70,000 and 125,000 and accounts for 19 per cent of health expenditure (De Savigny et al, 2004a and b). In the case of cholera, the first epidemic in Africa was reported as far back as 1836 (Rees, 2000). Major outbreaks were next reported in 1970 and affected West Africa (Guinea), the horn of Africa (Ethiopia, Somalia and Sudan) and Kenya (Waiyaki, 1996). The most severe cholera outbreak on the African continent was in 1998, accounting for more than 72 per cent of the global total number of cholera cases and acutely affecting the Democratic Republic of Congo, Kenya, Mozambique, Uganda and the United Republic of Tanzania. Cholera outbreaks in East Africa have been reported to the World Health Organization (WHO) since 1972. In the Lake Victoria region of East Africa both malaria and cholera are common, with malaria endemic in the lowlands and epidemic in the highland areas and cholera endemic in the basin since the early 1970s (Rees, 2000).

Olago D, Marshall M, Wandiga SO, Opondo M, Yanda PZ, Kangalawe R, Githeko A, Downs T, Opere A, Kabumbuli R, Kirumira E, Ogallo L, Mugambi P, Apindi E, Githui F, Kathuri J, Olaka L, Sigalla R, Nanyunja R, Baguma T, Achola P. "Climatic Socio-economic and Health Factors Affecting Human Vulnerability to Cholera in the Lake Victoria Basin East Africa." AMBIO: A Journal of the Human Environment. 2007;36:350-358.
Yaşargil MG. Clinical {Considerations}, {Surgery} of the {Intracranial} {Aneurysms} and {Results}. Newyork: Thieme; 1984. Abstract

Clinical Considerations, Surgery of the Intracranial Aneurysma and Results

Yaşargil MG. Clinical {Considerations}, {Surgery} of the {Intracranial} {Aneurysms} and {Results}. Thieme; 1984. Abstract

Clinical Considerations, Surgery of the Intracranial Aneurysma and Results

Duque RB, Ynalvez M, Sooryamoorthy R, aul Mbatia P, aul Mbatia P, esley Shrum W. "Collaboration paradox: Scientific productivity, the Internet, and p roblems of research in developing areas." Social Studies of Science. 2005;5(35):755-785.
Yuga ME, Kimani, P.M; Kimani JM, Kimani PM, Olubayo MF, Muthomi JW, Nzuve FM. "Combining Ability and Heterosis for Agronomic and Yield Traits in Indica and Japonica Rice Crosses." Journal of Agricultural Science . 2018;10(12):92-103.
Yenesew A., and Dagne WAE. "A comparative study of Anthraquinones in rhizomes of some Kniphofia species." Biochemical Systematics and Ecology. 1988; 16 :157-159. Abstractpaper_5_yenesew_et_al_biochemical_sys_eco_1988_16_157.pdf

The anthraquinone content of eight kniphofia species was compared using reversed phase HPLC method coupled with a photodiode array detector.

Ochanda H, Young AS, Wells C, Medley GF, undefined. "Comparison of the transmission of Theileria parva between different instars of Rhipicephalus appendiculatus. ." Parasitology. 1996;113:243-253.
Muthee SM, Salim AM, Onditi AO, Yusuf AO. "Concentration Levels of Iron (Fe), Copper (Cu), Lead (Pb), Cadmium (Cd), Chromium (Cr) and Selected Nutrients in Water of Motoine River Channel, Kibera, Kenya." Chemical Science International Journal. 2018;24(1):1-8. AbstractJournal article

Abstract

The need for clean and safe consumable water is of paramount importance to any society since water is a crucial substance for the sustenance of life. Kibera slum is one of the leading slums in the world with a high population, leading to poor levels of sanitation and inadequate clean water supply. Consequently, the residents have to seek for alternative water supply. Motoine River flows through the slum, and thus acts as an alternative source of water. This study determined the concentration levels of heavy metals (Pb, Fe, Cu, Cr and Cd) and nutrients (nitrates, nitrites and phosphates) in Motoine River, Kibera in September 2014 and compared the variations downstream. The metals were determined using Atomic Absorption Spectroscopy (AAS) while the nutrients were determined using UV/Visible spectroscopy. Concentration levels of Cu, Cd and Cr were found to be lower than the Environmental Protection Agency (EPA) values for maximum contaminant level (MCL) while those of Fe, Pb and the nutrients were higher than EPA’s MCL values. Cd had the lowest concentration and was below the detection limit of the instrument used. Nitrates were found to be of the highest concentration at 16.4959 ± 2.4432 parts per million (ppm). The high concentration of nutrients in the water could be due to domestic waste and effluent disposal into the river and agricultural runoffs while that of metal ions could be due to waste from informal jua kali industries and erosion of natural deposits. The efforts by the government to rehabilitate and clean rivers within Nairobi should be extended to include Motoine River.

Yenesew A, Irungu BN, Erdélyi M., Orwa, J.A. GFLKMAPG. "Constituents of the roots and leaves of Ekebergia capensis and their potential antiplasmodial and cytotoxic activities." Molecules . 2014;19:14235-14246. Abstractirungu_et_al_molecules-2014-19-14235-v2.pdf

A new triterpenoid, 3-oxo-12β-hydroxy-oleanan-28,13β-olide (1), and six known
triterpenoids 2–7 were isolated from the root bark of Ekebergia capensis, an African
medicinal plant. A limonoid 8 and two glycoflavonoids 9–10 were found in its leaves. The
metabolites were identified by NMR and MS analyses, and their cytotoxicity was evaluated
against the mammalian African monkey kidney (vero), mouse breast cancer (4T1), human
larynx carcinoma (HEp2) and human breast cancer (MDA-MB-231) cell lines. Out of the
isolates, oleanonic acid (2) showed the highest cytotoxicity, i.e., IC50’s of 1.4 and 13.3 μM
against the HEp2 and 4T1 cells, respectively. Motivated by the higher cytotoxicity of the
crude bark extract as compared to the isolates, the interactions of oleanonic acid (2) with five triterpenoids 3–7 were evaluated on vero cells. In an antiplasmodial assay, seven
of the metabolites were observed to possess moderate activity against the D6 and W2
strains of P. falciparum (IC50 27.1–97.1 μM), however with a low selectivity index
(IC50(vero)/IC50(P. falciparum-D6) < 10). The observed moderate antiplasmodial activity
may be due to general cytotoxicity of the isolated triterpenoids.

Keywords: Ekebergia capensis; tritepenoid; antiplasmodial; cytotoxicity; Vero; 4T1;
HEp2; MDA-MB-231; 3-oxo-12β-hydroxy-oleanan-28,13β-olide

Mbugua MN, Yusuf AO, Bhatt BM, P.M. G. "CONVERSION OF VERNONIA GALAMENSIS OIL TO PYRIDINYLVERNOLAMIDES AND THEIR ANTIMICROBIAL ACTIVITIES ." Bulletin of the Chemical Society of Ethiopia. 2007;21(1):103-110.bcse_21_1_vernonia_galamensis_2007.pdf
Subramanian S, Gakunga R, Kibachio J, Gathecha G, Edwards P, Ogola E, Yonga G, Busakhala N, Munyoro E, Chakaya J, Ngugi N, Mwangi N, Von Rege D, Wangari L-M, Wata D, Makori R, Mwangi J, Mwanda W. "Cost and affordability of non-communicable disease screening, diagnosis and treatment in Kenya: Patient payments in the private and public sectors." PLoS ONE. 2018;13(1):e0190113. Abstract

The prevalence of non-communicable diseases (NCDs) is rising in low- and middle-income countries, including Kenya, disproportionately to the rest of the world. Our objective was to quantify patient payments to obtain NCD screening, diagnosis, and treatment services in the public and private sector in Kenya and evaluate patients' ability to pay for the services.

Okuda Y, Adrogue HJ, Field JB, Nohara H, Yamashita K. "Counterproductive effects of sodium bicarbonate in diabetic ketoacidosis." The Journal of Clinical Endocrinology and Metabolism. 1996;81:314-320. Abstract

Although a growing body of evidence supports that alkali therapy in diabetic ketoacidosis (DKA) might be counterproductive, our knowledge about the consequences of this treatment on ketone metabolism is limited. Consequently, we performed clinical and animal studies to further examine this topic. The clinical studies assessed seven patients with DKA treated with continuous insulin infusion at a low dosage. Three of them also received sodium bicarbonate (NaHCO3), whereas the remaining four acted as controls. The group receiving NaHCO3 showed a 6-h delay in the improvement of ketosis as compared with controls. In addition, there was an increase in acetoacetate (AcAc) levels during alkali administration, followed by an increase in 3-hydroxybutyrate (3-OHB) level after its completion. Significant differences were not found between groups in the response of plasma glucose to the overall therapy. The animal study examined the effects of a NaHCO3-rich perfusate on the hepatic production of ketones with the in situ rat-liver preparation. Alkali loading resulted in an immediate increase in the AcAc level followed by increases in both the 3-OHB level and the 3-OHB/AcAc ratio after its completion. Hepatic ketogenesis increased even further, to about twice the basal level, after termination of the NaHCO3 loading. This investigation confirms that alkali administration augments ketone production and unravels an effect of bicarbonate infusion that promotes a selective build up of AcAc in body fluids. The data support that alkali therapy in DKA has nonsaltuary effects in the metabolism and plasma levels of ketones.

Yaouba S, Valkonen A, Coghi P, Gao J, Guantai EM, Derese S, Wong VKW, Erdélyi Máté, Yenesew A. "Crystal Structures and Cytotoxicity of ent-Kaurane-Type Diterpenoids from Two Aspilia Species." Molecules. 2018;23(12):31-99. Abstract

A phytochemical investigation of the roots of Aspilia pluriseta led to the isolation of ent-kaurane-type diterpenoids and additional phytochemicals (1–23). The structures of the isolated compounds were elucidated based on Nuclear Magnetic Resonance (NMR) spectroscopic and mass spectrometric analyses. The absolute configurations of seven of the ent-kaurane-type diterpenoids (3–6, 6b, 7 and 8) were determined by single crystal X-ray diffraction studies. Eleven of the compounds were also isolated from the roots and the aerial parts of Aspilia mossambicensis. The literature NMR assignments for compounds 1 and 5 were revised. In a cytotoxicity assay, 12α-methoxy-ent-kaur-9 (11), 16-dien-19-oic acid (1)(IC 50= 27.3±1.9 µM) and 9β-hydroxy-15α-angeloyloxy-ent-kaur-16-en-19-oic acid (3)(IC 50= 24.7±2.8 µM) were the most cytotoxic against the hepatocellular carcinoma (Hep-G2) cell line, while 15α-angeloyloxy-16β, 17-epoxy-ent-kauran-19-oic acid (5)(IC 50= 30.7±1.7 µM) was the most cytotoxic against adenocarcinomic human alveolar basal epithelial (A549) cells.

Yenesew A, Gumula I, Erdélyi M, Patrick. A, J Isaiah Omolo Ndiege PS, Omolo, N, Sunnerhagen P. "Cytotoxic and Antioxidant Flemingins G-P from the Leaves of Flemingia grahamiana." Journal of Natural Products . 2014. Abstractpaper_76_ivan_et_al_jnp_2014_77_2060_2067.pdf

The known flemingins A-C (1-3) and nine new chalcones, named flemingins G-O (4-12), along with deoxyhomoflemingin (13) and emodin (14) were isolated from a leaf extract of Flemingia grahamiana. The isolated chalcones were found to have a geranyl substituent modified into a chromene ring possessing a residual chain, as shown by spectroscopic methods. The leaf extract showed an IC50 value of 5.9 μg/mL in a DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging assay. The chalcones flemingins A, B, C, G, and H were active in the DPPH radical scavenging assay (ED50 4.4-8.9 μM), while flemingins A and C showed cytotoxicity against MCF-7 human breast cancer cells (IC50 8.9 and 7.6 μM, respectively).

Adem FA, Kuete V, Mbaveng AT, Heydenreich M, Ndakala A, Irungu B, Efferth T, Yenesew A. "Cytotoxic benzylbenzofuran derivatives from Dorstenia kameruniana." Fitoterapia. 2018;128:26-30. Abstract

Chromatographic separation of the extract of the roots of Dorstenia kameruniana (family Moraceae) led to the isolation of three new benzylbenzofuran derivatives, 2-(p-hydroxybenzyl)benzofuran-6-ol (1), 2-(p-hydroxybenzyl)-7-methoxybenzofuran-6-ol (2) and 2-(p-hydroxy)-3-(3-methylbut-2-en-1-yl)benzyl)benzofuran-6-ol(3) (named dorsmerunin A, B and C, respectively), along with the known furanocoumarin, bergapten (4). The twigs of Dorstenia kameruniana also produced compounds 1–4 as well as the known chalcone licoagrochalcone A (5). The structures were elucidated by NMR spectroscopy and mass spectrometry. The isolated compounds displayed cytotoxicity against the sensitive CCRF-CEM and multidrug-resistant CEM/ADR5000 leukemia cells, where compounds 4 and 5 had the highest activities (IC50 values of 7.17 μM and 5.16 μM, respectively) against CCRF-CEM leukemia cells. Compound 5

Yenesew A, Sunnerhagen, P., Erdelyi M, Abdissa N, Induli, M., Fitzpatrick P, Alao JP, Landberg G. "Cytotoxic Quinones from the Roots of Aloe dawei." Molecules. 2014;19,:3264-3273. Abstractpaper_69_abdissa_et_al_molecules_2014.pdf

Seven naphthoquinones and nine anthraquinones were isolated from the roots of Aloe dawei by chromatographic separation. The purified metabolites were identified by NMR and MS analyses. Out of the sixteen quinones, 6-hydroxy-3,5-dimethoxy-2-methyl-1,4-naphthoquinone is a new compound. Two of the isolates, 5,8-dihydroxy-3-methoxy-2-methylnaphthalene-1,4-dione and 1-hydroxy-8-methoxy-3-methylanthraquinone showed high cytotoxic activity (IC₅₀ 1.15 and 4.85 µM) on MCF-7 breast cancer cells, whereas the others showed moderate to low cytotoxic activity against MDA-MB-231 (ER Negative) and MCF-7 (ER Positive) cancer cells.

Omosa LK, Mbogo GM, Korir E, Omole R, Ean-JeongSeo, Yenesew A, Midiwo MHJO, Efferth T. "Cytotoxicity of Fagaramide Derivative and Canthin-6-one from Zanthoxylum (Rutaceae) Species against Multidrug Resistant Leukemia Cells." Natural Products Research. 2019;https://doi.org/10.1080/14786419.2019.1587424:1-8.omosa_et_al_2019 pdf
Omosa LK, Mbogo GM, Korir E, Omole R, Ean-JeongSeo, Yenesew A, Heydenreich M, Midiwo JO, Efferth T. "Cytotoxicity of fagaramide derivative and canthin-6-one from Zanthoxylum (Rutaceae) species against multidrug resistant leukemia cells." Natural product research. 2019:1-8. Abstract

In our continuous search for cytotoxic compounds from the genus Zanthoxylum, chromatographic separation of the MeOH/CH2Cl2 (1:1) extract of Z. chalybeum yielded one new alkamide; 4-(isoprenyloxy)-3-methoxy-3,4-deoxymethylenedioxyfagaramide (1) and a known one; fagaramide (2). Similarly, from the MeOH/CH2Cl2 (1:1) extract of the stem bark of Z. parachanthum four known compounds; canthin-6-one (3), dihydrochelerythrine (4), lupeol (5) and sesamin (6) were isolated. Characterization of the structures of these compounds was achieved using spectroscopic techniques (NMR and MS). Using resazurin reduction assay 1, 3 and 6 displayed moderate cytotoxicity with IC50 values below 50 μM against the drug sensitive CCRF-CEM and multidrug-resistant CEM/ADR5000 leukemia cell lines. It is interesting to note that 3 was more active than the standard drug, doxorubicin against CEM/ADR5000 leukemia.

Omosa LK, Mbogo GM, Korir E, Omole R, Ean-JeongSeo, Yenesew A, Heydenreich M, Midiwo JO, Efferth T. "Cytotoxicity of fagaramide derivative and canthin-6-one from Zanthoxylum (Rutaceae) species against multidrug resistant leukemia cells." Natural product research. 2019:1-8. Abstract

In our continuous search for cytotoxic compounds from the genus Zanthoxylum, chromatographic separation of the MeOH/CH2Cl2 (1:1) extract of Z. chalybeum yielded one new alkamide; 4-(isoprenyloxy)-3-methoxy-3,4-deoxymethylenedioxyfagaramide (1) and a known one; fagaramide (2). Similarly, from the MeOH/CH2Cl2 (1:1) extract of the stem bark of Z. parachanthum four known compounds; canthin-6-one (3), dihydrochelerythrine (4), lupeol (5) and sesamin (6) were isolated. Characterization of the structures of these compounds was achieved using spectroscopic techniques (NMR and MS). Using resazurin reduction assay 1, 3 and 6 displayed moderate cytotoxicity with IC50 values below 50 μM against the drug sensitive CCRF-CEM and multidrug-resistant CEM/ADR5000 leukemia cell lines. It is interesting to note that 3 was more active than the standard drug, doxorubicin against CEM/ADR5000 leukemia …

Adem FA, Mbaveng AT, Kuete V, Heydenreich M, Ndakala A, Irungu B, Yenesew A, Efferth T. "Cytotoxicity of isoflavones and biflavonoids from Ormocarpum kirkii towards multi-factorial drug resistant cancer." Phytomedicine. 2019;58:152-853. Abstract

While incidences of cancer are continuously increasing, drug resistance of malignant cells is observed towards almost all pharmaceuticals. Several isoflavonoids and flavonoids are known for their cytotoxicity towards various cancer cells.

Buyinza D, Yang LJ, Derese S, Ndakala A, Coghi P, Heydenreich M, Wong VKW, Möller HM, Yenesew A. "Cytotoxicity of isoflavones from Millettia dura." Natural Product Research. 2019:1-4. AbstractNatural Product Research

Abstract

The first phytochemical investigation of the flowers of Millettia dura resulted in the isolation of seven isoflavones, a flavonol and a chalcone. Eleven isoflavones and a flavonol isolated from various plant parts from this plant were tested for cytotoxicity against a panel of cell lines, and six of these showed good activity with IC50 values of 6-14 μM. Durmillone was the most active with IC50 values of 6.6 μM against A549 adenocarcinomic human alveolar basal epithelial cancer cell line with low cytotoxicity against the non-cancerous cell lines BEAS-2B (IC50 = 58.4 μM), LO2 hepatocytes (IC50 78.7 μM) and CCD19Lu fibroblasts (IC50 >100 μM).
Keywords: Millettia dura, Leguminosae, isoflavone, cytotoxicity.

D
Yamoah CF;, Mulongoy K;, Agboola AA;, Ssali H;, Keya SO. "Decomposition and nitrogen contribution by prunings of selected legumes in alley cropping."; 1985.
Mbugua P, Salim A, Onditi A, Yusuf A. "Determination of Micronutrients and micronutrients in Soil Samples from Around Lake Ol-Bolossat." Int. J. Biol. Sci.. 2010;2(8):140-148.scan0016.pdf
Yangyuoru PM, Otieno AC, Mwongela SM. "Determination of Sphingosine Kinase 2 Activity using Fluorescent Sphingosine by Capillary Electrophoresis." Electrophoresis. 2011;32(13):1742-9.
Sola L, Levin NW, Johnson DW, Pecoits-Filho R, Aljubori HM, Chen Y, Claus S, Collins A, Cullis B, Feehally J, Harden PN, Hassan MH, Ibhais F, Kalantar-Zadeh K, Levin A, Saleh A, Schneditz D, Tchokhonelidze I, Kazancioglu RT, Twahir A, Walker R, Were AJO, Yu X, Finkelstein FO. "Development of a framework for minimum and optimal safety and quality standards for hemodialysis and peritoneal dialysis." Kidney International Supplements. 2020.
Christophe Long, Yannick Aussagues, Nicolas Molinier LMLVASVPPCMBF. "Dichapetalins from Dichapetalum species and their cytotoxic properties." Phytochemistry . 2013;94:184-191.
Ghimire C, Park S, Iida K, Yangyuoru P, Otomo H, Yu Z, Nagasawa K, Sugiyama H, Mao H. "Direct quantification of loop interaction and π–π stacking for G-quadruplex stability at the submolecular level." Journal of the American Chemical Society. 2014;136(44):15537-15544.
Ghimire C, Park S, Iida K, Yangyuoru P, Otomo H, Yu Z, Nagasawa K, Sugiyama H, Mao H. "Direct quantification of loop interaction and π–π stacking for G-quadruplex stability at the submolecular level." Journal of the American Chemical Society. 2014;136(44):15537-15544.
Jumba IO, Wandiga SO, LALAH JO, YUGI PO, BARASA MW. "The distribution of organochlorine pesticides in marine samples along the Indian Ocean coast of Kenya.". In: Environmental Technology (U.K.) 23, 1235-1246. Association of Africa Universities; 2002. Abstract

The concentrations of organochlorine residues of lindane, aldrin, <*- endosulfan, dieldrin, endrin, p,p'-DDE, p,p'-DDD and p,p'-DDT in samples of seawater, sediment, fish and seaweed from different locations along the coast of Kenya are discussed in relation to the geographical location of the sampling sites and potential sources of residue over a period of two years. All sediment samples were found to contain very low levels of organic carbon except those sampled from Sabaki River that had high (4.7%) organic carbon due to greater primary activity. Most of the pesticides residues (112 samples analysed in 1997 and 258 analysed in 1998/99) were detected in fish, water, sediments and seaweed. The concentration of some residues was higher during the wet season than the dry season in 1997, but no marked seasonal variation was observed in 1998/99. Lindane, aldrin, p,p'-DOT and p,p'-DDE were the most frequently observed residues in all samples while «-endosulfan, dieldrin, p,p'-DDD and endrin were either present in low concentrations or absent in most samples. Water samples had the lowest concentrations of residues (range 0.503 - 9.025 ng g'1). Sediments had the second highest levels of pesticides residues with a range of 0.584 - 59.00 ng g'1 while fish lipid content had the highest levels of residues in 1989/99 with p,p'-DDT concentration of 1011 ng g'1 and 418 ng g"1 p,p'-DDD 'mSiganus rivulatus.

Anthony Egeru, Oliver Wasonga, Mburu J, Yazan E, Majaliwa MGJ, MacOpiyo L, Bamutaze Y. "Drivers of forage availability: An integration of remote sensing and traditional ecological knowledge in Karamoja sub-region, Uganda." Pastoralism. 2015;5:19. Abstract
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Yangyuoru PM, Antonio MD, Ghimire C, Biffi G, Balasubramanian S, Mao H. "Dual Binding of an Antibody and a Small Molecule Increases the Stability of TERRA G‐Quadruplex." Angewandte Chemie International Edition. 2015;54(3):910-913.
P.G J, and Yajnik A-AISKN. "Duodenal perforation following blunt abdominal trauma: A case report." East African Medical Journal . 1998;(75):669.
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YUKO- DRJOWICHRISTINEA. "Echocardiographic patterns of juvenile rheumatic heart disease at the Kenyatta National Hospital, Nairobi. East Afr Med J . 2005 Oct; 82 ( 10 ): 514-9 . PMID: 16450679 [PubMed - indexed for MEDLINE] Yuko-Jowi C, Bakari M.". In: East Afr Med J . 2005 Oct; 82 ( 10 ): 514-9 . uon press; 2005. Abstract
Department of Paediatrics and Child Health, College of Health Sciences, University of Nairobi, P.O. Box 19676-00202 Nairobi, Kenya. OBJECTIVE: To describe the echocardiographic features of children with rheumatic heart disease seen at the Kenyatta National Hospital. DESIGN: A retrospective study. SETTING: The Kenyatta National Hospital Heart Unit. SUBJECTS: Patients aged 20 years and less with echocardiographic diagnosis of rheumatic heart disease. RESULTS: Two hundred and twenty four echocardiograms were analysed. Seventy six point four of cases were aged between 5 and 15 years, while on 3% were less than five years. The combinations mitral and aortic regurgitation was the most common lesion followed by isolated mitral regurgitation. Isolated aortic regurgitation was as rare as isolated mitral stenosis in the paediatric age group 1.8% and 2.7% respectively. When seen in the younger age group, the leaflet morphology in mitral regurgitation was predominantly thickening and clubbing of the leaflets while in the older children the pathology was of marked fibrosis of the sub-valvular apparatus. Leaflet prolapse and commissural fusion was the major pathology in aortic regurgitation. Pulmonary hypertension was the most common complication commonly seen in mitral valve disease. Calcification was a rare encounter in this age bracket. CONCLUSIONS: Rheumatic heart disease in the paediatric age commonly presents as isolated mitral regurgitation or in combinations of mitral and aortic regurgitation. The complications of pulmonary hypertension was predominant in mitral valve disease. Valvular calcification is rare in juvenile rheumatic heart disease. PMID: 16450679 [PubMed - indexed for MEDLINE]
Mukabana RW, Kannady K, Kiama MG, Ijumba JN, Mathenge EM, Ibrahim Kiche, Nkwengulila G, Mboera L, Mtasiwa D, Yamagata Y, Schayk IV, Knols BGJ, Lindsay SW, de Castro MC, de Castro MC, Tanner M, Fillinger U, Killeen GF. "Ecologists can enable communities to implement malaria vector control in Africa.". In: Malaria Journal, 5 (1): 9. Journal of School of Continuous and Distance Education ; 2006. Abstract

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Integrated vector management (IVM) for malaria control requires ecological skills that are very scarce and rarely applied in Africa today. Partnerships between communities and academic ecologists can address this capacity deficit, modernize the evidence base for such approaches and enable future scale up. Community-based IVM programmes were initiated in two contrasting settings. On Rusinga Island, Western Kenya, community outreach to a marginalized rural community was achieved by University of Nairobi through a community-based organization. In Dar es Salaam, Tanzania, Ilala Municipality established an IVM programme at grassroots level, which was subsequently upgraded and expanded into a pilot scale Urban Malaria Control Programme with support from national academic institutes. Both programmes now access relevant expertise, funding and policy makers while the academic partners benefit from direct experience of community-based implementation and operational research opportunities. The communities now access up-to-date malaria-related knowledge and skills for translation into local action. Similarly, the academic partners have acquired better understanding of community needs and how to address them. Until sufficient evidence is provided, community-based IVM remains an operational research activity. Researchers can never directly support every community in Africa so community based IVM strategies and tactics will need to be incorporated into undergraduate teaching programmes to generate sufficient numbers of practitioners for national scale programmes. Academic ecologists at African institutions are uniquely positioned to enable the application of
practical environmental and entomological skills for malaria control by communities at grassroots
level and should be supported to fulfil this neglected role.

Mukabana, W.R., K. Kannady, G.M. Kiama, J. Ijumba, E.M. Mathenge, I. Kiche, G. Nkwengulila, L.E.G. Mboera, D. Mtasiwa, Y. Yamagata, I. van Schayk, B.G.J. Knols, S.W. Lindsay, M. Caldas de Castro, H. Mshinda, M. Tanner, U. Fillinger, Killeen GF. "Ecologists can enable communities to implement malaria vector control in Africa." Malaria Journal. 2006;5(1):9.
Kobia EN, Ochanda H, Yole DS. "The effect of immunizing Swiss white mice with snail soluble proteins and challenging them with Schistosoma mansoni." The Internet Journal of Tropical Medicine. 2012;8(1):DOI: 10.5580/2b3f.
Teng W, Shan Z, Teng X, Guan H, Li Y, Teng D, Jin Y, Yu X, Fan C, Chong W, others. "Effect of iodine intake on thyroid diseases in {China}." New England Journal of Medicine. 2006;354:2783-2793. AbstractWebsite
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Yumbya P, Ambuko J, Shibairo S, Owino W. "Effect of Modified Atmosphere Packaging (MAP) on the Shelf Life and Postharvest Quality of Purple Passion Fruit (Passiflora Edulis Sims)." Journal of Post-Harvest Technology. 2014;2:25-36. Abstract
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and Yalla GPPO. "Effect of National Strategy Implemetation on Competitiveness: A case of Kenya's Trade, International Marketing and Investment Strategies." International Journal of Business and Public Management. 2011;Vol 1, No. 1: (April, 2011):60-68.
Yole DS, Obanda VO, Kithome K, Ochanda H. "The effect of vaccinating S. mansoni-infected BALB\c mice either before or after treatment. ." African Journal of Health Sciences . 2005;12:65-77.
YUKO- DRJOWICHRISTINEA. "The effects of Percutaneous balloon mitral Valvotomy on pulmonary venous flow. Yonga G, Bonhoeffer P, Jowi C. EAMJ, Vol 76, No 1 , Page 28 ,1999.". In: EAMJ, Vol 76, No 1 , Page 28. uon press; 1999. Abstract
OBJECTIVE: To study the effect of percutaneous balloon mitral valvotomy (PBMV) on the deranged systolic and diastolic pulmonary venous flows in mitral stenosis. DESIGN: Open, non-randomised, case-control study. SETTING: Mater Misericordiae Cardiac Catheterisation Laboratory and Kenyatta National Hospital Cardiac Catheterisation Laboratory. PATIENTS: Twelve consecutive patients with severe symptomatic mitral stenosis with valve characteristics suitable for PBMV on echocardiographic evaluation. INTERVENTION: Percutaneous baloon mitral valvotomy. MAIN OUTCOME MEASURES: Peak systolic and diastolic pulmonary flow velocities and velocity time integrals (VTI). RESULTS: Peak sytolic pulmonary flow velocity increased from 29.8 +/- 9.6 to 46.1 +/- 8.5 cm/s p < 0.01) and systolic VTI from 2.6 +/- 1.0 to 5.5 +/- 0.9 cm (p < 0.01). Peak diastolic flow velocity increased from 39.3 +/- 5.7 to 43.0 +/- 6.9 cm/s (p < 0.05) and diastolic VTI from 3.9 +/- 1.5 to 4.8 +/- 1.6 cm (p < 0.05). Mean mitral valve area increased from 0.65 +/- 0.15 to 1.98 +/- 0.34 cm2 (p < 0.001) and mean left atrial pressures from 30.5 +/- 9.1 to 11.9 +/- 5.1 mmHg (p < 0.001). CONCLUSIONS: In patients with severe mitral stenosis and sinus rythm, left atrial filling is biphasic with diastolic preponderance. Successful PBMV causes predominant increase in atrial systolic filling.
Ambuko J, Yumbya MP, Shibairo S, Owino WO. "Efficacy of 1–methylcyclopropene in purple passion fruit (Passiflora edulis Sims) as affected by dosage and maturity stage." International Journal of Postharvest Technology and Innovation. 2014;4:126-137. Abstract
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Owino WO, Yumbya P, Shibairo S, Ambuko J. "Efficacy of Activebag® packaging on postharvest quality of purple passion fruit (Passiflora edulis Sims).". In: XXIX International Horticultural Congress on Horticulture: Sustaining Lives, Livelihoods and Landscapes (IHC2014): 1120.; 2014:. Abstract
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Kweka 4. EJ, Owino EA, Lee M-C, Dixit A, Yousif E. Himeidan, Mahande AM. "Efficacy of resting boxes baited with carbon dioxide versus CDC light trap for sampling mosquito vectors: A comparative study." Global Health Perspectives . 2013;1(1):11-18.
Miruka AC, Kariuki DK, Yusuf AO, Onyatta JO. "Efficiency of a Wastewater Treatment Plant in the City of Nairobi." International Journal of Sciences: Basic and Applied Research (IJSBAR). 2018;38(1):152-162.
Ochanda H, Young AS, Medley GF, Shaw MK, Perry BD. "Efficiency of transmission of Theileria parva stocks by different instars of Rhipicephalus appendiculatus. .". In: British Society for Parasitology Spring . University of Bath ; 1994.
Yohannis MA, Agnes N. Wausi, Hutchinson MJ, Waema TM. "Enhancing Access and Use of Climate Information through ICTs." Journal of Climate Change and Sustainability. 2019;3(1):1-12. AbstractWebsite

Although the role of ICTs in improving human life in Kenya is acknowledged widely, the focus of much
of ICT-related developments has been on human experiences at the level of disease and needs for
communication and mobility. Less obvious is how such technological interventions may be used to
address seemingly abstract yet grave concerns like climate change and its impact on the quality of human
life. This review paper, therefore, shall investigate the different situations where ICTs may be deployed
in relaying packaged and relevant localized climate information that can help rural farmers in Kitui
County, Kenya to make pertinent and timely decisions to improve their productivity and, ultimately, their
livelihoods. We hypothesize that rural communities' use ICT tools such as the mobile phones and the
community radios to access localized climate information (weather, seasonal forecasts, and agroadvisories)
and that livelihood assets and livelihood strategies positively change with the increasing
availability and use of the ICT-based climate information. The idea of the paper presented is to merge
theoretical and applied research outcomes to narrow the gap between the theory of ICTs usage and the
practice of it, while linking it to climate information and enhanced rural livelihood strategies. The review
of this paper shall be captured in social-scientific terms, and shall contribute to knowledge by helping
researchers and policymakers to determine climate information needs of rural ASAL communities,
knowledge on innovations related to ICTs, among others.

Y E. "Environmental considerations shaping the hospital building and governing its space.". In: AMEK 3rd Scientific Conference & Exhibition,. NHIF Building, Nairobi.; 2005.
Muyera Z, Yegon E, Wanjiru M. "Environmental Scanning (ES) in the digital age: application of Web 2.0 tools in information institutions.". In: CHRISTIAN ASSOCIATION OF LIBRARIANS IN AFRICA-KENYA. Nakuru; 2015.
Wabomba JN, Shiundu PM, Onyari JM, Yanful E. "Equilibrium and Kinetic Studies of Cu (Ii) Removal from Aqueous Solutions Using a Kenyan Micaceous Mineral." International Journal of Innovation Education and Research. 2017;5(4):181-198. AbstractInternational Journal of Innovation Education and Research

Description
Copper (II) sorption on a Kenyan micaceous mineral (Mica-K) was studied in the batch mode. The effects of different experimental parameters such as; initial concentration, contact time, sorbent dose, pH, particle size, agitation speed, competition and temperature on the kinetics of copper removal were studied. The sorption pattern of copper onto Mica-K followed Langmuir and Freundlich isotherms. Thermodynamic parameters for copper sorption on Mica-K were also determined. X-ray photoelectron spectroscopic (XPS) analysis of metal ion-equilibrated Mica-K, demonstrated that copper, cadmium and Zinc containing nodules existed on the surface of Mica-K.

Wabomba JN, Shiundu PM, Onyari JM, Yanful E. "Equilibrium and Kinetic Studies of Cu(Ii) Removal from Aqueous Solutions Using a Kenyan Micaceous Mineral.". 2017. AbstractFull text link

Copper (II) sorption on a Kenyan micaceous mineral (Mica-K) was studied in the batch mode. The effects of different experimental parameters such as; initial concentration, contact time, sorbent dose, pH, particle size, agitation speed, competition and temperature on the kinetics of copper removal were studied. The sorption pattern of copper onto Mica-K followed Langmuir and Freundlich isotherms. Thermodynamic parameters for copper sorption on Mica-K were also determined. X-ray photoelectron spectroscopic (XPS) analysis of metal ion-equilibrated Mica-K, demonstrated that copper, cadmium and Zinc containing nodules existed on the surface of Mica-K.

MayumiNomura, Yamaguchi H, Motegi E, Rugh JD, Ng’ang’a PM, Gakunga PT, Hatch JP. "Esthetic preferences of European American, Hispanic American, Japanese, and African Judges for soft - tissue profiles.". 2009.
Young AS, Dolan TT, Mwakima FN, Ochanda H, Mwaura SN, Njihia GM, Muthoni MW, Dolan RB. "Estimation of heritability of susceptibility to infection with Theileria parva in the tick Rhipicephalus appendiculatus." Parasitology. 1995;111:31-38.
Kasima E, Yusuf A, Kariuki K, Abong'o D. "Evaluation of efficiency of Kipevu wastewater treatment plant in Mombasa County, Kenya." Scholar. 2004.

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