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Kahiga RM, Gatumu JC, Nteere JS. "Sustainability of the implementation of the Preschool physical education curriculum in Nairobi and Nyeri counties.". In: Africa for Research in Comparative Education Society. Kenya Science Campus; Forthcoming.
Kiplagat D. STRATEGY FOR THE IMPLEMENTATION AND ADOPTION OF E-PROCUREMENT IN KENYA PUBLIC SECTOR. Wausi D, ed. Nairobi: University of Nairobi; Forthcoming. Abstract

There is strong consensus among researchers and practitioners regarding the strategic importance of developing efficient purchasing techniques to increase transparency and fairness, reduce corruption, ensure competitiveness and reduce costs. An increasing number of government authorities are adopting e-procurement solutions to reap the above stated benefits (Panayiotou et al., 2004). E-procurement is the process of purchasing goods and services electronically , and can be defined as “the use of integrated (commonly web-based) communication systems for the conduct of part or all of the purchasing process; a process that may incorporate stages from the initial need identification by users, through search, sourcing, negotiation, ordering, receipt, payment and post-purchase review” (Presutti,2003).

In this research proposal I propose to comprehensively study through explorative case study five successful cases of e-procurement in the public sector in Korea, Australia, Italy, Ireland, Philippine's and use their experiences, challenges and strategies employed to come up with a multi-disciplinary framework for the successful implementation and adoption of e-procurement in the public sector in Kenya. In this research critical successes factors (CSFs) and diffusion of innovation theory will be used in the study. Explorative case study and qualitative research design methodology will be used in this research study although aspects on the attitude of the intended users will be analyzed quantitatively.

Kiai, Wambui and Ngugi M. Voices of Media Veterans: Reflections over 70 Years on Communication and Media in Kenya. Nairobi: University of Nairobi & Ford Foundation; Forthcoming.
Gona, George, Wambui Kiai, Muiru Ngugi (Eds.). Women in Public Space(s) in Kenya. University of Nairobi & Ford Foundation; Forthcoming.
Submitted
K. M, Mbote PK, Musembi C. Women's Access to Land Land-based Resources among Forest-dwelling Communities in East Africa:. Nairobi: CASELAP, University of Nairobi; Submitted.
K. M, Mbote PK, Musembi C. Women's Access to Land Land-based Resources among Forest-dwelling Communities in East Africa:. Nairobi: CASELAP, University of Nairobi; Submitted.
Kunyanga CN, Imungi JK, Biesalski HK. " http://www.sciencedirect.com/science/article/pii/S0023643811002659 http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/17023 .". Submitted. AbstractWebsite

Certain indigenous foods commonly consumed by Kenyan vulnerable groups (the malnourished; children under 5 years of age; pregnant and lactating women; malnourished adults in cases of vitamin or mineral deficiencies, TB, diabetes, cancer, AIDS; refugees; orphans the elderly and the disabled) are not yet evaluated for phenolic content and health relevant functionality. The present study was therefore designed to analyze the phenolic content, antioxidant and antidiabetic properties of methanolic extract of raw and traditionally processed food ingredients. The total phenolic contents of the cereals, legumes, oil seeds and vegetables were ranged from 0.41 to 3.00 g/100 g DM. Amaranth grain (Amaranthus cruentus) and drumstick leaves (Moringa oleifera) exhibited significantly higher phenolic content than the other samples. The methanolic extract of the investigated samples showed promising levels of DPPH radical scavenging activity (81–89%); ferric reducing/antioxidant power (FRAP, 44–744 mmolL−1 Fe[II]/g extract DM); α-amylase (10–45%) and α-glucosidase (13–80%) inhibition activities. The food ingredients with high phenolic content exhibited relatively higher antioxidant and antidiabetic activities. The results indicate that soaking + cooking is the mild processing method to preserve the phenolic compounds and their health relevant functionality in the presently investigated cereal, legume and oil grains, while cooking is suitable treatment for vegetables.

Akech M, Kameri-Mbote P. "7) Kenyan Courts and Politics of the Rule of Law in the Post-Authoritarian State ." EAST AFRICAN JOURNAL OF PEACE AND HUMAN RIGHTS. Submitted;18(357 ):2.
Kariuki S, Mirza N, Mitema ES, Olsvik O. "Acquired tetracycline resistance genes in nosocomial Salmonella typhimurium infection in a Kenyan hospital.". Submitted. AbstractWebsite

Tetracyclines have been among the most widely used antibiotics worldwide. Plasmid-mediated tetracycline resistance among hospital strains of bacteria has continued to rise and of major concern has been the transfer of resistance to pathogenic organisms. Bacteraemia due to hospital acquired S. typhimurium has been a major cause of morbidity at Kenyatta National Hospital (KNH), hence the need to study drug susceptibility pattern of this organism. This study also characterized the tetracycline resistance genes using oligonucleotide probes. Ninety seven S. typhimurium strains isolated from patients at KNH were used. Agar dilution method was used to determine minimum inhibitory concentration (MIC). Plasmids were isolated from each strain and the different plasmid profiles were grouped by their molecular weights into 6 patterns. Out of 97, 87 (88%) strains were resistant. MIC ranged from 1 microgram/ml to 128 micrograms/ml. Genes encoding for tetracycline resistance were located on plasmids of molecular weights 65 MDa, 5.2 or both. Plasmid-encoded antimicrobial resistance is likely to spread to other pathogenic organisms, reduce our ability to treat the infection and increase the cost and duration of treatment.

IRIBEMWANGI PI, Kabwana I. Alfa na Omega (Play). Nairobi: Oxford University Press; Submitted. Abstract

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Jani PG, Gill H, Kotecha V. "Difficult Gallbladder Surgery, Improving Patient Outcomes Through Appropriate Surgical Decisions." East and Central African Journal of Surgery. Submitted;17(1).
KAGURE PROFKARANIANNE. "Dr. Peninnah M. Kako, Prof. Anna K. Karani, Prof.Patricia E. Stevens Reactions to HIV Diagnosis from Women Living with HIV in Kenya.". In: Paper presented at Safari Park Hotel STTI Conference on 3rd July, 2010. Dr.Peninnah M.Kako, Prof. Anna K. Karani, Prof.Patricia E. Stevens; Submitted. Abstract

Background: HIV prevalence in Kenya stands at 7.8%, with women being most affected with infection rates being 2-3 times higher than that of their male counterparts.  Studies that focus on health needs of HIV-infected women in Kenya are needed and necessary. Purpose: The purpose of this study was to develop an in-depth understanding of the reactions of 40 urban and rural HIV-infected Kenyan women to HIV diagnosis. Methods: Narrative inquiry principles were employed to guide this qualitative cross-sectional study. We conducted in-depth interviews using open-ended questions in April and May 2006.  Findings: Participants

Mbuge DO, Kanyara MM, B.K.Mutai E, Murunga S, Mutuli DA, Agullo J. "The Effect of Drying Temperature on Nutrient levels in Oyster Mushroom." AJST. Submitted; ( ). Abstractdocument_2.pdf

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Thongoh MW, Mutembei HM, Mburu J, Kathambi BE. "Evaluating Knowledge, Attitudes and Practices of Livestock Value Chain Actors on Climate Smart Agriculture/Livestock (CSA/L) in Kajiado County, Kenya." Asian Journal of Agricultural Extension, Economics & Sociology. Submitted;39(4):134-148.
Muirhead JD, Kattenhorn SA, Lee H, Mana S, Turrin BD, Fischer TP, Kianji G, Dindi E, Stamps DS. "Evolution of upper crustal faulting assisted by magmatic volatile release during early-stage continental rift development in the East African Rift." Geosphere. Submitted;12(6):1-31.
Kiseli J, Kitati EM. Factors That Affect Internal Control Systems In Public Institutions. Riga, Latv ia: LAP LAMBERT Academic Publishing; Submitted. AbstractFactors That Affect Internal Control Systems In Public Institutions

Internal control is the process effected by an organization’s structure, to assist the organization to accomplish specific goals or objectives. It is a means by which an institution’s resources are directed, monitored and measured. It plays an important role in preventing and detecting fraud and protecting the organization’s resources. Internal Control mechanisms’ comprises of the control environment and control procedures. It includes all the policies and procedures adopted by the directors and management of an entity to help in achieving their objectives of ensuring, as far as practicable, the orderly and efficient conduct of its business, including adherence to internal policies, the safeguarding of assets, the prevention and detection of frauds and errors, the accuracy and completeness of the accounting records, and the timely preparation of reliable financial information. The internal control systems extend beyond those matters which relate directly to the accounting system. Internal control is concerned with the control operative in every area of corporate activity, as well as with the way in which individual controls interrelate.

Mungai NN, Kibwage IO, Mwangi JW, Guantai AN, Njogu PM, Ongarora DSB. "Isolation, Characterization and Antiplasmodial Activity of Phytochemical Constituents from Monanthotaxis parvifolia (Oliv.) Verdc ssp. kenyensis Verdc." East and Central African Journal of Pharmaceutical Sciences. Submitted;17:87-93.abstract__mungai_et_al._2014.pdf
Weinstein, A. EORTALWAGMCSS, Ebinger, C. ORTALWAGMSSC, Oliva, S. RTALWAGMSCM, Roecker, S. TALWAGMCMC, Tiberi, C. ALWAGMMCE, Aman, M. LWAGMCEJ, Lambert, C. WAGMEJS, Witkin, E. AGMJS, Albaric, J. GMS, Gautier, S. M, Muzuka, A. MKHI-KMFPMRGGR, Mulibo, G. KG, Kianji, G., Hadfield, R. I-KMFPMRFMR, Illsley-Kemp, F. MFPMRMRS, Msabi, M. FPMRRSJ, Ferdinand, R. PMRSJ, Peyrat, S. MRJ, Muirhead, J. R, Rodzianko, A., Fischer T. "Magmatic Co2 assisted rifitng in East Africa : seismicity of the Magadi-Natron-Manyara basins, Africa. Submitted to Tectonics." tectonics. Submitted.
IRIBEMWANGI PI, Kilonzo P. Matata (Play). Nairobi: E.A. E. P; Submitted.
Omonge E;, Kyateesa; J, Otieno FCF;, Kayima, Lule G;, McLigeyo AA. Metabolic factors associated with the development of lipodystrophy in patients on long-term highly active anti-retroviral therapy (HAART).; Submitted. Abstract

Dyslipidemia, insulin resistance and diabetes are frequent in patients on highly active anti-retroviral
therapy (HAART) and especially in patients with lipodystrophy, and may lead to atherosclerosis. This
study described the metabolic alterations associated with lipodystrophy in adults on chronic HAART in
Kenya. The prevalence of dyslipidaemia amongst the study participants was (211) 79.6%. Elevated total
cholesterol was found in 129, high low-density-lipoprotein cholesterol (LDL-C) in 107, low High-density
lipoprotein cholesterol (HDL-C) in 110 and high triglycerides in 131 participants. Lipodystrophic
patients were more likely to have dyslipidemia than normal lipids (55.4 versus 35.1%, p = 0.007 OR 2.2
CI 1.3 to 4.6) with 57, 45.9, 65.9 and 45.2% having elevated total cholesterol, elevated LDL-C, elevated
triglycerides and low HDL-C, respectively. Hypertriglyceridemia and hypercholesterolemia were
significantly associated with lipodystrophy (OR 3.8 CI 2.3 to 6.4; p = 0.000) and (OR 1.94 CI 1.2 to 3.2; p
= 0.008), respectively. The odds of lipodystrophy was 2.913 times higher for patients with elevated
triglycerides than for those with normal triglycerides (p < 0.001). Sixty-four (24.3%) participants had
dysglycemia, with 3.5% having diabetes and 20.8% having impaired fasting glucose (IFG). Among
patient with lipodystrophy, 69.8% had normal fasting glucose, 25.1% had IFG and 5.1% were diabetic.
Lipodystrophic patients were not more likely to have abnormal blood sugars than normal blood sugars
(p value 0.125).

KAGURE PROFKARANIANNE. "Ms Chore Jane Njambi; Prof. Anna Karani Dr. Margaret Chege. Assessment of Challenges Facing Preceptors at Kenyatta National Hospital Specialized Units.". In: Kenya Nursing Journal, vol. 40:1: 6-13. Impress Communication Printers and Stationers; Submitted. Abstract

The main aim of this cross-sectional descriptive study was to assess challenges faced by preceptors at Kenyatta National Hospital specialized units. The study was conducted among preceptors with more than one year experience at Kenyatta National Hospital specialized units and combined both quantitative and qualitative methods. Data was collected using a self administered semi-structured questionnaire distributed to 113 randomly sampled preceptor nurses and an interview guide was used to collect qualitative data from five unit managers. The data was coded, computed and analyzed by SPSS version 17 (qualitative data was analyzed manually).Commonly reported challenges by preceptors included; heavy patient workload 85.71%, lack of adequate resources 59.52% and a high number of students attached to a preceptor 59.52%. Chi square was used to establish relationships between variables. Motivation to serve as a preceptor was strongly associated with the number of years a participant had served as a nurse. (X=11.30; p=0.01).

Parton WJ, Scurlock JMO, Ojima DS, Gilmanov TG, Scholes RJ, Schimel DS, Kinyamario JI. "Observations and modeling of biomass and soil organic matter dynamics for the grassland biome worldwide.". Submitted. AbstractObservations and modeling of biomass and soil organic matter dynamics for the grassland biome worldwide

Century is a model of terrestrial biogeochemistry based on relationships between climate, human management (fire, grazing), soil properties, plant productivity, and decomposition. The grassland version of the Century model was tested using observed data from 11 temperate and tropical grasslands around the world. The results show that soil C and N levels can be simulated to within ±25% of the observed values (100 and 75% of the time, respectively) for a diverse set of soils. Peak live biomass and plant production can be simulated within ± 25% of the observed values (57 and 60% of the time, respectively) for burned, fertilized, and irrigated grassland sites where precipitation ranged from 22 to over 150 cm. Live biomass can be generally predicted to within ±50% of the observed values (57% of the time). The model underestimated the live biomass in extremely high plant production years at two of the Russian sites. A comparison of Century model results with statistical models showed that the Century model had slightly higher r2 values than the statistical models. Data and calibrated model results from this study are useful for analysis and description of grassland carbon dynamics, and as a reference point for testing more physiologically based models prediction's of net primary production and biomass. Results indicate that prediction of plant and soil organic matter (C and N) dynamics requires knowledge of climate, soil texture, and N inputs.

MWANGI EN, KAAYA GP, ESSUMAN S, KIMONDO MG. "Parasitism of Amblyomma variegatum by a Hymenopteran Parasitoid in the Laboratory, and Some Aspects of Its Basic Biology.". Submitted. AbstractParasitism of Amblyomma variegatum by a Hymenopteran Parasitoid in the Laboratory, and Some Aspects of Its Basic Biology

Unfed Amblyomma variegatum F. nymphs were experimentally infected in the laboratory with a hymenopteran parasitoid, Ixodiphagus hookeri (Howard). The parasitoid was originally obtained from ticks collected from cattle in the Trans-Mara area of Kenya where it naturally infects 50% of A. variegatum nymphs. In the field, nymphs collected from cattle were found to be infected, but not those collected from grass. The optimum temperature for emergence of parasitoids from the nymphs in the laboratory was 28°C, but emerged parasitoids were more active and survived longer at 22°C. There was a higher proportion of parasitoid nonemergence from laboratory-infected than from the field-infected nymphs. This study is the first record of infection of A. variegatum in the laboratory with a parasitoid. Possibilities of mass rearing and use of the parasitoid as a biocontrol agent for ticks are discussed.

Kilonzo BM. A Plastic Anaemia At The Kenyatta National Hospital During The Period 1973-1978.; Submitted. Abstract

A total of 54 patients were diagnosed and treated for plastic anaemia between July, 1973 to December 1978 at the Kenyatta National Hospital. The sex distribution was equal. Most of the age groups were affected with the majority of Cases occurring in the young age groups.
Most tribes in Kenya were found not to be free from a plastic anaemia and there was a predominance of the disease amongst the Kikuyu tribe who lived in and around Nairobi.
Very few factors associated with actiology could. Be elicited and this was partially due to adequate histoties taken at the time of admission by the various physicians. Even though great difficulties are encountered in establishing an aetiologic role for a given agent, so that in large proportion of patients remains unexplained.
The presenting clinical features were those of anaemic haemorrhages due to thrombocytopenia and infections resulting from leucopenia, all of which were observed in all the patients reviewed except for the 4 patients with pure red cell aplasia.
The other 50 patients had hypoplastic marrows. Confirmation of diagnosis was delayed due to initial blood transfusion given before peripheral blood film examination in most patients.
Massive blood transfusion was given to patients on remission. Although platelet concentrates are available and obviate the massive blood transactions, only very few patients received platelet infusions.
Corticosteroid and androgenic asteroids were administered but there was no laid down policy as to the protocol to be followed. Hence administration of these drugs was done in a haphazard manner with a big proportion of patients going without any steroid therapy. This may have accounted to a great extent, for the very poor remission rate noted.
Since it has been observed that pure red cell aplacia remits spontaneously, prolonged therapy of these patients should be pursued vigorously.
Most of the deaths encountered occurred during the first 4 months of admission and they were mainly due to complications of the disease process mainly infections, congestive cardiac failure and excessive haemorrhage.

Muma MK, Kimani K, Kariuki – Wanyoike MM, ILAKO DR, Njuguna MW. "Prevalence of Refractive errors among Primary School Pupils in Kilungu Division of Makueni District, Kenya.". Submitted. Abstract

To determine the magnitude and pattern of significant refractive errors in primary school children in Kilungu division of Makueni District, Kenya. Design: A cross – sectional primary school based study. Setting: Eight (8) Primary school in Kilungu division of Makueni District, Kenya. Target population: 1439 Primary school pupils aged between 12 and 15 years. Results: The prevalence of significant refractive error was 5.2%, 75/1439, (95% CI) being responsible for 92.6 % of all causes of poor eyesight. Hypermetropia accounted for 3.2% (95% CI), myopia 1.7% (95% CI) and astigmatism 0.3% (95% CI) of refractive errors. Myopia was more likely to be present in the pupils aged 14 to 15 years than those aged 12 to 13 years with OR 2.9 (0.1 – 9.2) which was statistically significant (p = 0.022). Conclusion: The overall prevalence of significant refractive errors in pupils aged 12 to 15 years in Makueni's Kilungu division at 5.2% (95% CI) was high enough to justify a regular school eye screening in primary schools in Kenya.

Muia JMK, Kariuki JN, Mbugua PN, Gachuiri CK, Lukibisi LB, Ayako WO, Ngunjiri WV. "Smallholder dairy production in high altitude Nyandarua milk-shed in Kenya: Status, challenges and opportunities.". Submitted. AbstractWebsite

A stratified sampling method was used to select 156 dairying households from representative Divisions in Nyandarua County. The stratification was based on cattle grazing systems (CGS) and agro-ecological zones (AEZs) across the Divisions. The objectives of the study were to assess status of smallholder dairy cattle production in relationship to CGS and AEZ, major challenges facing smallholder dairy production, and the opportunities for improvement. Data collected included the characteristics of the farm, family, farmer, feeds and feeding, dairy cattle and their performance, milk uses and markets, and the dairy production services. The information on the challenges facing dairy production and the opportunities for improvement was obtained from discussions with livestock extension workers, dairy co-operatives, milk processors, and from secondary sources. The present results indicated that the average farm size was 3.5 Ha and 41, 38, and 44% of the households fed dairy stock with improved fodders, grass hay, and concentrate supplements, respectively. Among the households, about 44, 38 and 32% had access to artificial insemination (AI), extension, and all weather roads services, respectively. Households keeping crosses of the dairy breeds were 59% while the average herd size was 5.3 heads consisting of 40% cows in milk. The average calf live-weight gain was 322g/ day and milk yield per cow was 8.4kg/day. About 65% of the milk was marketed at an average price of 15.00 KES/kg, equivalent to 0.205 US$/kg. As the levels of dairy intensification increased, there were significant increase in milk production per hectare and decrease in calf live-weight gains (P<0.05). On the other hand, as the level of agricultural potential increased, there were significant decreases in milk production and marketed milk per farm (P<0.05). It was concluded that smallholder dairy cattle production was below the potential for Nyandarua County and was influenced by the CGS and AEZs. The major challenges in smallholder dairy production included poor road network and milk marketing, high costs and inaccessibility of dairy production inputs and support services, inappropriate dairy production technologies, and limited value addition of milk.

Katende J, Pokhariyal G. "A study of Sasakian Manifolds." Far East Journal of Mathematical Sciences. Submitted.
Gripenberg U, Saarinen I, Bwibo NO, Oduori ML, Grayburn JA, Awori NW, Wasunna AE, Kinuthia DM. "Two true hermaphrodites with XX chromosomes.". Submitted.
Akunda EM, Kumar B. "Using internal plant water status as a criterion for scheduling irrigation in coffee in east of rift valley Kenya.". In: Kenya coffee vol. 47. No. 560, 281- 284. Kisipan, M.L.; Submitted. Abstract

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Nkonya E, Xiong W, Deustua J, Kato E. "Why do many smallholder farmers fail to adopt improved land management practices which can improve yields and incomes? The reason is not always because these practices are uneconomical but sometimes it is because resource poverty prevents farmers from tak.". Submitted. AbstractWebsite

Why do many smallholder farmers fail to adopt improved land management practices which can improve yields and incomes? The reason is not always because these practices are uneconomical but sometimes it is because resource poverty prevents farmers from taking advantage of yield and income enhancing agricultural practices. In this study we examine the relative merits of using a carbon payment scheme compared to a subsidy policy to help reduce the cost of specific land management practices with productivity and ecosystem benefits such as carbon sequestration. Using a 30-year crop simulation model, we examine the impacts of different soil fertility management treatments (SFTs) on yields and soil carbon and proceed to compute discounted incremental revenue streams over the same period. We find that the SFTs simulated are on average profitable given the conditions assumed in our DSSAT simulations. When carbon was priced at $8 or $12/t CO2e, the increase in incremental incomes generated from a carbon payment were invariably higher than those imputed from a 50% fertilizer subsidy. When carbon was priced at $4/Co2e, the increase was almost similar and sometimes higher than that from the imputed income transfer from a 50% subsidy. If these indications hold in further research, it could imply that using fertilizer subsidies as the sole mechanism for stimulating adoption of improved soil fertility management practices may unnecessarily forgo other complementary and possibly superior alternatives. Depending on the specific economic equity considerations, we conclude that either of these instruments can be used to help farmers break through resource barriers that prevent them from adopting productivity-enhancing and environmentally beneficial agricultural practices. However, given the fiscal burden on public finances and possible opportunity costs of any substantial subsidy program, it is possible that a carbon payment system can be a reasonable alternative assuming the range of carbon prices used in this study and especially if accompanied by measures to ameliorate the costs of fertilizer to farmers.

KAGURE PROFKARANIANNE. "1. Naruse Kazuko, Tashiro Junko, Sankyo Yumi, Ichikawa Wakako, Karani Anna Stakeholders.". In: Annual Scientific Conference of National Nurses Association of Kenya on 5th - 7th October, 2011 at Kagumo Teachers College in Nyeri, Kenya. Blackwell Publishing Co.; Submitted. Abstract

After the World Health Assembly approved WHA 45.5 in 1992 addressing the nursing shortage by refocusing nurses and midwifes to meet community health needs, community demands for educated nurses and the needs of higher nursing education in developing countries increased.  Therefore in Kenyan a major university school of nursing initiated a collaborative study with a well established Japanese nursing college to determine the service-providers

KAGURE PROFKARANIANNE. ": PERCEPTION OF BACHELOR OF SCIENCE IN NURSING (BScN) ON THEIR ROLE ON NURSING IN A HOSPITAL SETTING Prof. Anna K. Karani University of Nairobi, Stephen Kainga,(MScN) University of Nairobi Prof. Simon Kangethe Moi University. Diana Mwarania BScN (graduate.". In: Kenya Nursing Journal: Dec. KNJ Vol. 41(2) 23-33. Impress Communications; Submitted. Abstract

The study was conducted to investigate the clinical Competence of Bachelor of Science Nursing graduates working at Kenyatta National Hospital in March 2011. The objective was to assess the perceptions of graduate nurses about the nursing profession and the implications on the development of BScN undergraduates from the University of Nairobi and other Universities with a view to improving their perception about the profession  through continuing education and curriculum review. It was a cross sectional study with a sample size of 50 nurses, total population selected on purpose. A supervised questionnaire and focus group discussion tools were used for data collection.  The findings indicated that majority of the Bachelor of Science Nursing graduates

K PROFNDELEJOHNSON. "Academia .". In: The Nairobi Journal of Medicine Vo. 19 No. 2 pp 30-34. University of Nairobi Press; Submitted. Abstract
The present studies were designed and carried out to determine if hydrogen peroxide (H2O2) is involved in the regulation of erythropoietin (Epo) gene expression and stimulation of Epo production in the hepatocellular (Hep 3B) cells. Hep 3B cells were incubated with varying concentrations of H2O2 for periods of 6 hours or 24 hours. In other experiments Hep 3B cells were incubated for 24 hours with or without increasing concentrations of catalase and in the presence of H2O2. Culture medium levels of Epo were determined and quantitation of Epo mRNA was also made. The results indicate that H2O2 increases the levels of Epo mRNA and Epo hormone production in Hep 3B cells, and that catalase, the specific scavenger of hydrogen peroxide, inhibits Epo production in these cells. Based on these findings, it is concluded that H2O2 takes part in the signal transduction mechanisms in Epo production. It is recommended that further studies be undertaken to find out the source of the hydrogen peroxide in the hepatocellular carcinoma cells.
KICHAMU MRAKIVAGASYMONDS. "Adult Education and political culture, S.K. Akivaga.". In: East Afr. Medi. Journal. Elsevier; Submitted. Abstract
Analysis of 355 cases with fractures of the mandible indicated that 74.9% of the cases were due to interpersonal violence and 13.8% were caused by road traffic accidents. The men to women ratio was 8.4:1 and 75.5% of the fracture cases had single fractures while 24.5% had multiple fractures. In cases with a single fracture, the most commonly involved mandibular site was the body (42.2%). The angle of mandible was most frequently fractured (50.5%) in cases with multiple fractures.
Aduda BOC, Egbe PDDDAM, Musembi RJ, WAITA SEBASTIAN, Kaduki KA, Simiyu J, Agacho A, Nyongesa F. "ANSOLE Mini-Symposium in Kenya (AMSK 2013).". Submitted. Abstract
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AKUMU PROFODIRAPATTSM, K. MRNGARISAMUEL. ""Application of Ground Charcoal as a Coarse Medium in Dual Media Filtration of Water". East African Journal of Engineering.". In: Jadini Beach Hotel, Mombasa. IBIMA Publishing; Submitted. Abstract
Joint exhibition of paintings and sculptures
AKUMU PROFODIRAPATTSM, K. MRNGARISAMUEL. ""Application of Ground Charcoal as a Coarse Medium in Dual Media Filtration of Water". East African Journal of Engineering.". In: Canadian and International Education Journal. VOL: 19, No:1'1990. Prof. James Otieno-Odek; Submitted. Abstract

This paper reports the detailed results of a study of the impact of the Health Workers for Change (HWFC) workshop series on clients' perceptions of health services, relationships within the health centre and relations between the health facility and the district health system. The study was carried out in three stages: baseline, intervention and evaluation over a period of 20 months. Data, both qualitative and quantitative, were collected at three levels: client, facility and system. Results indicate that relations between health workers and clients improved a great deal after the intervention while those between the facility and the system remained to a large extent unchanged. The paper concludes that, with external support and help, especially from the health system level, health workers can work towards improving health services and their job satisfaction, which can lead to better health worker-client relations.

AKUMU PROFODIRAPATTSM, K. MRNGARISAMUEL. ""Application of Ground Charcoal in the Removal of Organic Matter in Water Treatment". East African Journal of Engineering.". In: East African Journal of Engineering. IBIMA Publishing; Submitted. Abstract
Joint exhibition of paintings and sculptures
AKUMU PROFODIRAPATTSM, K. MRNGARISAMUEL. ""Application of Ground Charcoal in the Removal of Organic Matter in Water Treatment". East African Journal of Engineering.". In: East African Journal of Engineering. Prof. James Otieno-Odek; Submitted. Abstract

This paper reports the detailed results of a study of the impact of the Health Workers for Change (HWFC) workshop series on clients' perceptions of health services, relationships within the health centre and relations between the health facility and the district health system. The study was carried out in three stages: baseline, intervention and evaluation over a period of 20 months. Data, both qualitative and quantitative, were collected at three levels: client, facility and system. Results indicate that relations between health workers and clients improved a great deal after the intervention while those between the facility and the system remained to a large extent unchanged. The paper concludes that, with external support and help, especially from the health system level, health workers can work towards improving health services and their job satisfaction, which can lead to better health worker-client relations.

MUTUKU DRNZIMBIBERNARD, KIBET DRMOINDISTEPHEN, P PROFPOKHARIYALGANESH. "B.M. Nzimbi, G.P. Pokhariyal and S.K. Moindi, A note on A-self-adjoint and A-skew-adjoint operators and their extensions, Pioneer Journal of Mathematics and Mathematical Sciences, accepted January, 2012, to appear.". In: Pioneer Journal of Mathematics and Mathematical Sciences(PJMMS). Pioneer Journal of Mathematics and Mathematical Sciences; Submitted. Abstract
Aminoglutethimide (AG) 500 mg was administered orally to four normal volunteers and eight patients undergoing treatment for metastatic breast cancer. In each subject the acetylator phenotype was established from the monoacetyldapsone (MADDS)/dapsone (DDS) ratio. Acetylaminoglutethimide (acetylAG) rapidly appeared in the plasma and its disposition paralleled that of AG. A close relationship (P less than 0.01) was observed between the acetyl AG/AG and MADDS/DDS ratio suggesting that AG may undergo polymorphic acetylation like DDS. AG half-life was 19.5 +/- 7.7 h in seven fast acetylators of DDS and 12.6 +/- 2.3 h in five slow acetylators and its apparent metabolic clearance was significantly (P less than 0.01) related to the acetylAG/AG ratio. Over 48 h the fast acetylators excreted 7.7 +/- 4.4% of the administered AG dose in the urine as unchanged AG as compared to 12.4 +/- 2.8% in slow acetylators. A much smaller fraction of the dose was excreted as acetylAG: 3.6 +/- 1.5% by fast and 1.9 +/- 1.0% by slow acetylators respectively. After 7 days treatment with AG at an accepted clinical dose regimen to the eight patients there were significant reductions in the half-lives of AG (P less than 0.01) and acetylAG (P less than 0.01) and a trend (0.1 greater than P greater than 0.05) towards reduction of the acetylAG/AG ratio which became significant (P less than 0.05) if the one patient on a known enzyme inducer was omitted. The mean apparent volume of distribution was not significantly (P greater than 0.1) altered but the mean apparent systemic clearance of AG was increased (P less than 0.05). These changes are attributed to auto-induction of oxidative enzymes involved in AG metabolism.
MUTUKU DRNZIMBIBERNARD, KIBET DRMOINDISTEPHEN, P PROFPOKHARIYALGANESH. "B.M. Nzimbi, G.P. Pokhariyal and S.K. Moindi, A note on A-self-adjoint and A-skew-adjoint operators and their extensions, Pioneer Journal of Mathematics and Mathematical Sciences, accepted January, 2012, to appear.". In: Pioneer Journal of Mathematics and Mathematical Sciences(PJMMS). Pioneer Journal of Mathematics and Mathematical Sciences; Submitted.
MUTUKU DRNZIMBIBERNARD, P PROFPOKHARIYALGANESH, KIBET DRMOINDISTEPHEN. "B.M. Nzimbi, G.P. Pokhariyal and S.K. Moindi, A note on metric equivalence of operators, Far East Math Jourmal (FMJS), accepted March 2012, to appear.". In: Global Journal of Theoretical and Applied Mathematical Sciences(GJTAMS). Far East Math Science Journal; Submitted. Abstract
Aminoglutethimide (AG) 500 mg was administered orally to four normal volunteers and eight patients undergoing treatment for metastatic breast cancer. In each subject the acetylator phenotype was established from the monoacetyldapsone (MADDS)/dapsone (DDS) ratio. Acetylaminoglutethimide (acetylAG) rapidly appeared in the plasma and its disposition paralleled that of AG. A close relationship (P less than 0.01) was observed between the acetyl AG/AG and MADDS/DDS ratio suggesting that AG may undergo polymorphic acetylation like DDS. AG half-life was 19.5 +/- 7.7 h in seven fast acetylators of DDS and 12.6 +/- 2.3 h in five slow acetylators and its apparent metabolic clearance was significantly (P less than 0.01) related to the acetylAG/AG ratio. Over 48 h the fast acetylators excreted 7.7 +/- 4.4% of the administered AG dose in the urine as unchanged AG as compared to 12.4 +/- 2.8% in slow acetylators. A much smaller fraction of the dose was excreted as acetylAG: 3.6 +/- 1.5% by fast and 1.9 +/- 1.0% by slow acetylators respectively. After 7 days treatment with AG at an accepted clinical dose regimen to the eight patients there were significant reductions in the half-lives of AG (P less than 0.01) and acetylAG (P less than 0.01) and a trend (0.1 greater than P greater than 0.05) towards reduction of the acetylAG/AG ratio which became significant (P less than 0.05) if the one patient on a known enzyme inducer was omitted. The mean apparent volume of distribution was not significantly (P greater than 0.1) altered but the mean apparent systemic clearance of AG was increased (P less than 0.05). These changes are attributed to auto-induction of oxidative enzymes involved in AG metabolism.
MUTUKU DRNZIMBIBERNARD, P PROFPOKHARIYALGANESH, KIBET DRMOINDISTEPHEN. "B.M. Nzimbi, G.P. Pokhariyal and S.K. Moindi, A note on metric equivalence of operators, Far East Math Jourmal (FMJS), accepted March 2012, to appear.". In: Global Journal of Pure and Applied Mathematics(GJPAM),2012, to appear. Far East Math Science Journal; Submitted.
KAGURE PROFKARANIANNE. "Challenges in Accessing HIV-related Healthcare in Resource Limited Communities: Lessons from HIV-infected Women in Kenya.". In: Kenya Nursing Journal, 38(1) 24-31. Dr. Peninnah M. Kako,Univ.W1; Prof. Anna K. Karani,UoN & Prof. Patricia E. Stevens, Univ.W1; Submitted. Abstract

 Background: Increasing access to HIV-related health care is very important in access resource limited countries. In Kenya HIV prevalence increased in 2008 to 7.8 from 6.7 in 2003. Women are mostly affected with infection rates 2-3 times more than men. Challenges women face attempting to access HIV care is urgent.Purpose: Study sought to identify health needs of HIV infected women in Kenya grapple with.Method: Forty Urban (Nairobi) and rural (Eastern Province) infected women participated in the study. A cross sectional qualitative narrative study eilicited life stories of health needs. Unstructured in-depth interviews,tape recorded, transcribed and translated to English. Data analysis used N-vivo qualitative analysis soft ware. Multistage narrative analysis was used to explore emergent themes.Findings: Women of mean age 37 years and 3 years since diagnosis described prolonged illnesses sufferred by spouses, themselves and children burdened by inadequate HIV care.Conclusion: Early diagnosis and treatment Interventions are necessary for wellbeing and long life.

KAGURE PROFKARANIANNE. "Clinical competence of Nursing Graduates in Kenya. African Journal of Midwifery and Womens.". In: African Journal of Midwifery and Womens. 1. Margaret Njambi Chege, Ephantus W. Kabiru, Anna Karani and Anseline Derese; Submitted. Abstract

{ Abuse of substances of dependence have risen dramatically and spawned major health problems in Kenya. We conducted a study on the effects of post-basic psychiatric training on nurses

Kisumbi BK. COLLEGE OF HEALTH SCIENCES SCHOOL OF DENTAL SCIENCES. UNIVERSITY OF NAIROBI; Submitted. Abstract
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K PROFNDELEJOHNSON. "Geriatric Clinical Pharmacology. The Pharmacokinetic .". In: Journal of Medicine Vol. 2 No. 5 pp 2-8. University of Nairobi Press; Submitted. Abstract
The present studies were designed and carried out to determine if hydrogen peroxide (H2O2) is involved in the regulation of erythropoietin (Epo) gene expression and stimulation of Epo production in the hepatocellular (Hep 3B) cells. Hep 3B cells were incubated with varying concentrations of H2O2 for periods of 6 hours or 24 hours. In other experiments Hep 3B cells were incubated for 24 hours with or without increasing concentrations of catalase and in the presence of H2O2. Culture medium levels of Epo were determined and quantitation of Epo mRNA was also made. The results indicate that H2O2 increases the levels of Epo mRNA and Epo hormone production in Hep 3B cells, and that catalase, the specific scavenger of hydrogen peroxide, inhibits Epo production in these cells. Based on these findings, it is concluded that H2O2 takes part in the signal transduction mechanisms in Epo production. It is recommended that further studies be undertaken to find out the source of the hydrogen peroxide in the hepatocellular carcinoma cells.
Kairu WM, Gatari MM, MUIA ML, Mumenya SW,... "Health monitoring of concrete using rebar-guided ultrasound." pdfs.semanticscholar.org. Submitted. AbstractWebsite

Concrete is one of the commonly used materials worldwide in the construction industry due to its durability [1]. Civil infrastructures such as power plants, bridges and large buildings are typically built using concrete. It is typically composed of aggregate, sand, cement, water as …

MUTUKU DRNZIMBIBERNARD, KIBET DRMOINDISTEPHEN, MILE DRJUSTUSKITHEKA. "Justus K. Mile, Bernard M. Nzimbi and S.K. Moindi, On the characterization of Class R_1 of non-normal operators in a Hilbert space, Pioneer Journal of Mathematics and Mathematical Sciences(PMMS), accepted March 2012, to appear.". In: Pioneer Journal of Mathematics and Mathematical Sciences(PJMMS). Journal of Mathematics and Mathematical Sciences(PMMS); Submitted. Abstract
Aminoglutethimide (AG) 500 mg was administered orally to four normal volunteers and eight patients undergoing treatment for metastatic breast cancer. In each subject the acetylator phenotype was established from the monoacetyldapsone (MADDS)/dapsone (DDS) ratio. Acetylaminoglutethimide (acetylAG) rapidly appeared in the plasma and its disposition paralleled that of AG. A close relationship (P less than 0.01) was observed between the acetyl AG/AG and MADDS/DDS ratio suggesting that AG may undergo polymorphic acetylation like DDS. AG half-life was 19.5 +/- 7.7 h in seven fast acetylators of DDS and 12.6 +/- 2.3 h in five slow acetylators and its apparent metabolic clearance was significantly (P less than 0.01) related to the acetylAG/AG ratio. Over 48 h the fast acetylators excreted 7.7 +/- 4.4% of the administered AG dose in the urine as unchanged AG as compared to 12.4 +/- 2.8% in slow acetylators. A much smaller fraction of the dose was excreted as acetylAG: 3.6 +/- 1.5% by fast and 1.9 +/- 1.0% by slow acetylators respectively. After 7 days treatment with AG at an accepted clinical dose regimen to the eight patients there were significant reductions in the half-lives of AG (P less than 0.01) and acetylAG (P less than 0.01) and a trend (0.1 greater than P greater than 0.05) towards reduction of the acetylAG/AG ratio which became significant (P less than 0.05) if the one patient on a known enzyme inducer was omitted. The mean apparent volume of distribution was not significantly (P greater than 0.1) altered but the mean apparent systemic clearance of AG was increased (P less than 0.05). These changes are attributed to auto-induction of oxidative enzymes involved in AG metabolism.
J PROFCHINDIAMARK, KAVIN DRWAKOLI. "Koech KJ, Chindia ML, Wakoli KA, Gathece LW. Prevalence of oral lesions in HIV infection and their relationship with CD4 count at a Nairobi centre. African journal of oral health sciences,Vol 5 no2, 4-9.". In: African Journal of Oral Health Sciences,Vol 5 no2, 4-9. Hekima III (1) 27-42; Submitted. Abstract
Savanna ecosystems and origins of modern human behavior Hekima III (1) 27-42: (Journal of the Humanities and Social Sciences, University of Nairobi).
J PROFCHINDIAMARK, KAVIN DRWAKOLI. "Koech KJ, Chindia ML, Wakoli KA, Gathece LW. Prevalence of oral lesions in HIV infection and their relationship with CD4 count at a Nairobi centre. African journal of oral health sciences,Vol 5 no2, 4-9.". In: African Journal of Oral Health Sciences,Vol 5 no2, 4-9. Korean Society of Crop Science and Springer; Submitted. Abstract
OBJECTIVE: To determine the dental caries experience and knowledge on the causes and preventive measures for dental diseases. DESIGN: A community based cross-sectional descriptive study. SETTING: Elwak sub-district hospital, North Eastern Province, Kenya. SUBJECTS: One hundred and forty one adults who presented themselves during a dental check up at a sub-district hospital and gave written consent. MAIN OUTCOME MEASURES: Dental caries status and knowledge on its causes and preventive measures. The importance of outreach programmes in obtaining information as well as helping to alleviate the pain and suffering caused by dental diseases among communities living in remote areas is also revealed. RESULTS: Of the one hundred and forty one individuals, who were included in the study, 63.1% were women and 36.9% were men. Their ages ranged between 18 and over 65 years. 41.1% were in the 18-24-year age bracket. Regarding the oral health knowledge, 43% did not know any causes of dental diseases while 36%, 17% and 12% knew that diet, "dirt" on teeth and bacteria were possible causes, respectively. Fifty percent did not know any preventive measures for dental diseases while the rest indicated abstention from the consumption of sugary foods; and only 0.8% mentioned use of fluoridated toothpaste as a preventive measure for dental caries. 56.7% of the subjects were caries free. The mean DMFT for all ages was 3.4. Of those with caries 72.1% were women. CONCLUSION: There is a low level of oral health awareness and a moderately high level of dental caries experience in this community with women apparently carrying the biggest burden of dental caries.
KICHAMU MRAKIVAGASYMONDS. "Local Authorities in Kenya (H.E.B.) . forthcoming.". In: East Afr. Medi. Journal. Elsevier; Submitted. Abstract
Analysis of 355 cases with fractures of the mandible indicated that 74.9% of the cases were due to interpersonal violence and 13.8% were caused by road traffic accidents. The men to women ratio was 8.4:1 and 75.5% of the fracture cases had single fractures while 24.5% had multiple fractures. In cases with a single fracture, the most commonly involved mandibular site was the body (42.2%). The angle of mandible was most frequently fractured (50.5%) in cases with multiple fractures.
K. DRMANGOLIMAURICE. "Mangoli. M.K. "Optimal Long-term Reactive Power Planning Using Decomposition Techniques", Ph.D. Thesis. The Pennsylvania State University, U.S.A., Dec. 1991.". In: Published in a Journal Kenyan Geographer. ELOQUENT BOOKS NY, Strategic Book Group, Connecticut, USA. ISBN-978-1-60911-081-9.Pages1; Submitted. Abstract
Normal 0 false false false MicrosoftInternetExplorer4 st1:*{behavior:url(#ieooui) } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} Macrophytes have been shown to perform important ecological roles in Lake Naivasha. Consequently, various studies regarding the impact of biotic factors on the macrophytes have been advanced but related studies on environmental parameters have lagged behind. In an attempt to address this gap, sampling on floating species and submergents was carried out in eight sampling sites in 2003 to investigate how they were influenced by a set of environmental factors. Soil texture (sandy sediments; P < 0.05, regression coefficient = - 0.749) and wind were the most important environmental parameters influencing the distribution and abundance of floating macrophytes. Combination of soil texture and lake-bed slope explained the most (86.3%) variation encountered in the submergents. Continuous translocation of the floating dominant water hyacinth to the western parts by wind has led to displacement of the submergents from those areas. In view of these findings, the maintenance and preservation of the steep Crescent Lake basin whose substratum is dominated by sand thus hosting most submergents remain important, if the whole functional purpose of the macrophytes is to be sustained.
MUTUKU DRNZIMBIBERNARD, KIBET DRMOINDISTEPHEN, P PROFPOKHARIYALGANESH. "Moindi, S.K., Pokhariyal, G.P. and Nzimbi, B.M., W_4-Curvature tensor on a A-Einstein Sasakian manifold, Global Journal of Theoretical and Applied Mathematical Sciences(GJTAMS), accepted Feb 2012, to appear.". In: Global Journal of Theoretical and Applied Mathematical Sciences(GJTAMS). Global Journal of Theoretical and Applied Mathematical Sciences(GJTAMS); Submitted. Abstract
Aminoglutethimide (AG) 500 mg was administered orally to four normal volunteers and eight patients undergoing treatment for metastatic breast cancer. In each subject the acetylator phenotype was established from the monoacetyldapsone (MADDS)/dapsone (DDS) ratio. Acetylaminoglutethimide (acetylAG) rapidly appeared in the plasma and its disposition paralleled that of AG. A close relationship (P less than 0.01) was observed between the acetyl AG/AG and MADDS/DDS ratio suggesting that AG may undergo polymorphic acetylation like DDS. AG half-life was 19.5 +/- 7.7 h in seven fast acetylators of DDS and 12.6 +/- 2.3 h in five slow acetylators and its apparent metabolic clearance was significantly (P less than 0.01) related to the acetylAG/AG ratio. Over 48 h the fast acetylators excreted 7.7 +/- 4.4% of the administered AG dose in the urine as unchanged AG as compared to 12.4 +/- 2.8% in slow acetylators. A much smaller fraction of the dose was excreted as acetylAG: 3.6 +/- 1.5% by fast and 1.9 +/- 1.0% by slow acetylators respectively. After 7 days treatment with AG at an accepted clinical dose regimen to the eight patients there were significant reductions in the half-lives of AG (P less than 0.01) and acetylAG (P less than 0.01) and a trend (0.1 greater than P greater than 0.05) towards reduction of the acetylAG/AG ratio which became significant (P less than 0.05) if the one patient on a known enzyme inducer was omitted. The mean apparent volume of distribution was not significantly (P greater than 0.1) altered but the mean apparent systemic clearance of AG was increased (P less than 0.05). These changes are attributed to auto-induction of oxidative enzymes involved in AG metabolism.
MUTUKU DRNZIMBIBERNARD, KIBET DRMOINDISTEPHEN, P PROFPOKHARIYALGANESH. "Moindi, S.K., Pokhariyal, G.P. and Nzimbi, B.M., W_4-Curvature tensor on a A-Einstein Sasakian manifold, Global Journal of Theoretical and Applied Mathematical Sciences(GJTAMS), accepted Feb 2012, to appear.". In: Global Journal of Theoretical and Applied Mathematical Sciences(GJTAMS). Global Journal of Theoretical and Applied Mathematical Sciences(GJTAMS); Submitted.
Maina LG, Maingi N, Nga'Nga C, Waruiru R, Gakuya F, Kanduma E. "Molecular Identity and Phylogeny of Gastrointestinal Strongyle Nematodes in Migratory, Resident, and Sedentary Plains Zebras (Equus Quagga) in Masai Mara National Reserve and Lake Nakuru National Park, Kenya." Resident, and Sedentary Plains Zebras (Equus Quagga) in Masai Mara National Reserve and Lake Nakuru National Park, Kenya. Submitted. Abstract
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KAGURE PROFKARANIANNE. "Ms Emma Matheka, Prof. Anna Karani, Mr. L.P.Oteba, Mr. M.F. Otieno, Prof. Simon Kangehte THE ROLE OF HORMONAL CONTRACEPTIVES IN HIV INFECTION AMONG ANTENATAL MOTHERS IN MACHAKOS DISTRICT HOSPITAL.". In: Kenya Nursing Journal, vol. 40:1: 6-13. Ms Emma Matheka, Prof. Anna Karani, Mr. L.P.Oteba, Mr. M.F. Otieno, Prof. Simon Kangehte; Submitted. Abstract

This study was done at Machakos District Hospital in the Eastern province of Kenya between May and August 2007.Aim was to find out the role of hormonal contraceptives in HIV infection among antennal mothers. Analytical cross- sectional study design was used. Methodology. The sample size consisted of 144 antenatal mothers visiting the MCH clinic for PMTCT services among other services. The simple random sampling technique included every 8th antenatal mother visiting the PMTCT clinic who had no history of consisted condom use. All antenatal mothers who had not used condoms consistedly both contraceptive and non-contraceptive users who fell in the sampling frame acted as study subjects. This was on condition that they consented to participate in the study. A self

KAGURE PROFKARANIANNE. "Ms Gichigi Esther, Prof. Anna Karani Dr Margaret Chege .". In: Kenya Nursing Journal June, Vol. 39(1) 57-61. Ms Gichigi Esther, Prof. Anna Karani Dr Margaret Chege; Submitted. Abstract

Mentorship programs are offered to support students in program completion, confidence building and transitioning to further education or the work force. However mentoring relationships have been faced by challenges such as inadequate knowledge and negative attitude. This study aimed at evaluating knowledge, attitude and perceived benefits on mentorship among the nursing students in Kenyan universities. The study was conducted in September, 2009.  A descriptive cross sectional survey  used both qualitative and quantitative methods to gather information. The study participants were students from University of Nairobi (U.O.N) and Kenya Methodist University (K.E.M.U). A sample of 188 students was selected from a total population of 403 in both universities. The data were coded, entered and analyzed using statistical package for social sciences (SPSS). Presentation of data was done in form of descriptive statistics, frequency distribution and graphs. Pearsons chi square tests were used to compare the two groups. The tests level of significance was set at 5%. Results showed that there was a significance difference between mentorship programmes in the two institutions ( χ 2= 17.02,  d.f=1 , p < 0.001)           . Fourty four (72%) of the students at K.E.M.U felt that the program had positive impact on students

KAGURE PROFKARANIANNE. "Ms Grace Gachuiri, Prof. Anna Karani, Dr Margaret Chege THE ROLE OF CLINICAL PLACEMENT ON KRCHN GRADUATES PERFORMANCE IN THE NCK REGISTRATION EXAMINATION.". In: Kenya Nursing Journal 1st.July 2010. Ms Grace Gachuiri, Prof. Anna Karani, Dr Margaret Chege; Submitted. Abstract

The study sought to establish the factors affecting the diploma graduates performance in the Nursing registration examination. Necessitated by poor performance recorded in recent years, this study was aimed at seeking to establish the reasons why. This was a descriptive study. Quantitative data was collected using self-administered semi structured questionnaires from 75 KRCHN graduates working at Kenyatta National Hospital. The study areas were purposively selected and the study subjects selected through simple random sampling. Qualitative data was collected using a study from lecturers

KAGURE PROFKARANIANNE. "Ms Grace Wangechi Gachuiri, Prof. Anna Karani, Dr Margaret Chege IMPACT OF STUDENTS AND TEACHER CHARACTERISTICS ON PERFORMANCE OF DIPLOMA NURSE GRADUATES.". In: Kenya Nursing Journal June, Vol. 39(1) 57-61. Ms Grace Wangechi Gachuiri, Prof. Anna Karani, Dr Margaret Chege; Submitted. Abstract

Necessitated by poor performance recorded in recent years, this descriptive study sought to establish the impact of students and teacher characteristics on performance in the Nursing registration examination. The study combined both qualitative and quantitative methods. Quantitative data was collected using self-administered semi structured questionnaires from 75 KRCHN graduates working at Kenyatta National Hospital. The study areas were purposively selected and the study subjects selected through simple random sampling. Qualitative data was collected using a study guide from lecturers

KYALE DRKISUMBIBERNINA, M DRWAKIAGAJOHN. "Mungai T.C. Kisumbi B.K Wakiaga J.M and Ireri S.K : Patients.". In: Journal of Dental Research. University of Nairobi Press; Submitted. Abstract
This study was done to determine the nature of utilization of dental auxiliaries and medical emergencies in private dental surgeries in Kenya. A self administering questionnaire with pre-paid postage was mailed to 138 dentists. 27.5% responded. 81.6% used dental auxiliaries and the main reason was to improve efficiency in managing patients. 93.5% of the auxiliaries were on job trained secondary school graduates. 63.2% of the respondents delegated duties which were mainly non-clinical. 26.3% did not delegate any duties. In a descending order, the reasons for non delegation were: that it would be risky to patients, not allowed by law, they did not find it necessary and that auxiliaries were not held responsible if something went wrong. The main duties delegated to the auxiliaries were cleaning of instruments and sterilization, mixing of restorative materials and preparing amalgam. Delegation was done primarily based on auxiliaries capability to perform the procedure and meet the set standards. 57.9% indicated that they rarely encountered medical emergencies. Syncope was the commonest emergency encountered. 72.7% indicated that auxiliaries could not handle medical emergencies because they were not trained. It is concluded that most dentists did not delegate clinical duties to dental auxiliaries and medical emergencies were rare.
KYALE DRKISUMBIBERNINA. "Mutave R.J. and Kisumbi B.K: Attitude of urban Kenyan population towards replacement of teeth. Preliminary findings. Journal of Dental Research.". In: Journal of Dental Research. Taylor & Francis; Submitted. Abstract
OBJECTIVES: The aim was to study dimensional time-dependence of resin/ionomer formulations from 5 min age to one month and to separate out the intrinsic setting shrinkage and hygroscopic expansion effects, by using non-aqueous and aqueous storage media, respectively. METHODS: Materials studied included: A: resin-, B: metal- and C: polyphosphonate-modified glass-ionomer cements [GICs]; and controls of D: poly-acid modified composite [compomer]; and E: resin-composite. Separate specimen groups (n = 5) were stored in different storage-media: (i) silicone fluid; (ii) de-ionized water. Experiments were repeated at 23 and 37 degrees C. Volumetric changes of specimens (4 mm diameter x 6 mm height) were obtained via accurate mass measurements (to 10(-4) g), using Archimedes principle, with silicone or water also used as the Archimedean fluid. These measurements were made periodically over a 30 day period, post fabrication. RESULTS: In silicone at 23 degrees C, all materials underwent further gradual intrinsic shrinkage (after 5 min from mix). This was highly significant (p < 0.05) for the RM-GIC (A). At 37 degrees C, however the RM-GIC expanded, indicating that its cure is temperature-sensitive. In water, at 23 and 37 degrees C, the shrinkage was either partially offset (materials C, D, E), or replaced by appreciable expansions (materials A and B). Differences between RM-GIC (A) and MM-GIC (B) were significant (p < 0.05). SIGNIFICANCE: The deployment of dual storage media made an important contribution to the separate analysis of the volumetric changes due to the on-going setting chemistry in these systems and the time-dependent effects of an aqueous environment.
KAGURE PROFKARANIANNE. "NURSE.". In: Annual Scientific Conference on 5th-7th Oct. 2011 at Kagumo Teachers College - Nyeri, Kenya. National Nurses Association of Kenya; Submitted. Abstract

 Prof. Anna Karani on - Authentic Leadership focus on impact of integrity so that leadership is better prepared to face the toughest challenges, inspire transparency and trust. It requires building in mind the customers served. Behaviour change is essential for long term growth and it avoids peripheral vision. Focused leadership identifies the missing link, addresses priority issues and information that is accurate, complete, economical, flexible, reliable, simple, timely, and verifiable. Nurses have a purpose, a destiny and need to accomplish things. They are trained to make a difference in peoples

KAGURE PROFKARANIANNE. "Nyangena, E., Mutema, A. & Karani, A. Evaluation of clinical training in nursing in Kenya.". In: Baraton Interdisciplinary Research Journal - Dec. 2011 1(2) 22-30. Baraton Interdisciplinary Research Journal; Submitted. Abstract

 The  research evaluated clinical training provided by the academic institutions that offer Bachelor of Science in Nursing (BScN) program. The purpose of the study was to describe the adequacy of clinical training and the graduates preparedness for nursing practice. The study was conducted from Sept. 2008 to March 2010. Design was cross sectional using questionnaires and focus group interviews (FGI) methods to collect data. The sample comprised of 232 subjects including pre-service BScN graduates and nursing supervisors at four teaching and referral hospitals in Kenya. Results revealed that clinical training provided by academic institutions was adequate but quality of training varied widely among the training institutions. The conclusion was that clinical training provided by BScN programs in Kenya was of high quality. The study recommends that urgent attention was required by nurse educators to address identified gaps in clinical training especially clinical instruction and supervision.   

KIRETI DRVICTORN. "Osgood Schlatter disease: An Audit Profile of 35 Adolescents.". In: The Annals of African Surgery Volume 6 . Kireti VM, Atinga JEO; Submitted. Abstract
BackgroundOsgood-Schlatter disease is a common cause of anterior knee pain inthe adolescent. Treatment is usually conservative with surgery reservedfor those who do not respond to this treatment. There is little publishedwork regarding the experience with the disease in our local set up. This series documents the experience with 35 adolescents treated for the disease.DesignCase seriesSubjectsThirty five adolescents with clinical and radiological diagnoses ofOsgood-Schlatter disease at Nairobi and Kenyatta National Hospitals,between 2001and 2007.MethodPatients were evaluated for demographics, knee involvement, activitiesassociated with pain and treatment outcomeResultsThere were 28 males and 7 females, aged 10 to 16 years (mean 12.8years). Thirteen had bilateral knee involvement. Twenty two were involved in active sports while the rest had constant pain and unable to sit or kneel. A family history of the disease was documented in one case.Thirty adolescents responded well to the conservative treatment. Inthe five adolescents who underwent surgery, the patella tendon wasedematous with thickening of the tendon sheath and neovascularisation.All the operated adolescents returned to active sports with 6 weeks after the surgery.ConclusionOsgood-Schlatter disease is a self-limiting condition in majority ofadolescents. Surgery when indicated has an excellent outcome.
KAGURE PROFKARANIANNE. "Prof. Anna K. Karani ; Stephen Kainga; Prof. Simon Kangethe; Diana Mwarania - PERCEPTION OF BACHELOR OF SCIENCE IN NURSING (BScN) ON THEIR ROLE ON NURSING IN A HOSPITAL SETTING.". In: KNJ Dec. 2011; vol.41:2. Impress Communications; Submitted. Abstract

The study was conducted to investigate the clinical Competence of Bachelor of Science Nursing graduates working at Kenyatta National Hospital in March 2011. The objective was to assess the perceptions of graduate nurses about the nursing profession and the implications on the development of BScN undergraduates from the University of Nairobi and other Universities with a view to improving their perception about the profession  through continuing education and curriculum review. It was a cross sectional study with a sample size of 50 nurses, total population selected on purpose. A supervised questionnaire and focus group discussion tools were used for data collection.  The findings indicated that majority of the Bachelor of Science Nursing graduates

KAGURE PROFKARANIANNE. "Prof. Anna K. Karani RE - DISCOVERING THE CHRISTIAN NURSE.". In: Kenya Nursing Journal 1st.July 2010. Prof. Anna K. Karani; Submitted. Abstract

The old nurse was there during the colonial  era. They were trained mainly by missionaries who were Christians. Therefore, they had the discipline and the Christian foundation principles. The joy of a Christian institution like Kijabe is that it still has that foundation. So all is not lost. We have to make sure that the lost PASSION, LOVE & CARE are back in the nursing profession. We have to restore that passion. That idea or feeling

KAGURE PROFKARANIANNE. "Prof. Anna Karani Facing Today.". In: Paper presented at Safari Park Hotel STTI Conference on 3rd July, 2010. Prof. Anna K. Karani; Submitted. Abstract

A leader is one who has the  Vision to see, Faith to believe, Will to learn, Humility to serve, Courage to do, Resilience to rise up in times of knock downs. What  is leadership? The ability to get things done through people.  What challenges have you encountered in leadership as you work? How have you overcome these challenges? What sets you apart from everybody else? What is it that you do differently from the nurse of to-day? It is your leadership. The way you do things for the community you serve. The commitment to serve selflessly. The way you are disciplined. It is not just money.  We all want to learn how to become more effective leaders in providing health care to the  community. We have to prepare for many challenges with the advanced technology, rapid development, and fast changing health systems, emerging diseases, rising poverty, hard economic times, changing social systems, Education , political , environment, climate among many others that affect the communities we serve. Facing Today

KAGURE PROFKARANIANNE. "Prof. Anna karani, Prof. Simon Kangethe, Mr. Johannes Njagi, Njoka ,Media Resources in Medical Education: Critical issues and factors to consider in instructional media development in the training of health professionals.". In: African Journal of Midwifery and Womens. Prof. Anna karani, Prof. Simon Kangethe & Johannes Njagi Njoka; Submitted. Abstract

 Media resources are critical component in teaching and learning process. Studies indicate that media resources provide the substitute for direct learning experiences during instruction and enable educators to present the learners with the requisite experience necessary for the acquisition of appropriate knowledge, skills and attitudes.The researchers set out to explore the philosophical, psychological and educational basis that provides guidelines on the development of media resources in the effective education and training of health professionals. Methodology was a historical critique of information from books, journals,magazines and internet on media resources in Medical education.  The findings indicate that the process of media resources development and administration is highly creative venture according to Mason (1977).plan, prepare, present, preview and follow up activities after use of equipment. Therefore educators must be able to demonstrate these issues when developing and administering them. 

KAGURE PROFKARANIANNE. "Prof. Karani Anna : NURSE.". In: Annual Scientific Conference of National Nurses Association of Kenya on 5th - 7th October, 2011 at Kagumo Teachers College in Nyeri, Kenya. National Nurses Association of Kenya; Submitted. Abstract

Authentic Leadership focus on impact of integrity so that leadership is better prepared to face the toughest challenges, inspire transparency and trust. It requires building in mind the customers served. Behaviour change is essential for long term growth and it avoids peripheral vision. Focused leadership identifies the missing link, addresses priority issues and information that is accurate, complete, economical, flexible, reliable, simple, timely, and verifiable. Nurses have a purpose, a destiny and need to accomplish things. They are trained to make a difference in peoples

MWANIA MJM, GATARI MJ, MAINA MDM, KINYUA R. "Recycled waste plastics composite: Possible construction material for wind turbine blades." promitheasnet.kepa.uoa.gr. Submitted. AbstractWebsite

Electrical power supply in Sub Saharan Africa (SSA) is expensive and very low, and most families have no chance of accessing clean lighting and cooking power. Off grid systems are the best viable solution in SSA and wind energy has a potential. However, the components …

KAGURE PROFKARANIANNE. "ROLES OF MEDICAL EDUCATORS IN THE ADVANCEMENT OF HEALTH PROFESSIONS .". In: Kenya Nursing Journal - KNJ Vol. 41(2) 65-67. Impress Communications; Submitted. Abstract

Health care professionals are absorbed daily in the practices of their professional areas of specialization. Medical Educators,  spend their time catering to the educational needs of all health care professionals, whatever their specialization. A recent area of concern in the medical education curricula has been the inclusion of the topic

KAGURE PROFKARANIANNE. "S. Kangethe, A. Karani, J. Njagi, E Kamaara, C, Syallow, J.M. Ole Kiu, Mengich, Gladys. ROLES OF MEDICAL EDUCATORS IN THE ADVANCEMENT OF HEALTH PROFESSIONS .". In: KNJ Dec. 2011; vol.41:2. Impress Communications; Submitted. Abstract

Health care professionals are absorbed daily in the practices of their professional areas of specialization. Pediatricians, for example spend most of their time catering to the needs of children, while nurses, pharmacists and dentists in their own areas. Medical Educators, however, spend their time catering to the educational needs of all health care professionals, whatever their specialization. A recent area of concern in the medical education curricula has been the inclusion of the topic

KAGURE PROFKARANIANNE. "S. Kangethe, A. Karani, J. Njagi, E Kamaara, C, Syallow, J.M. Ole Kiu, Mengich, Gladys. ROLES OF MEDICAL EDUCATORS IN THE ADVANCEMENT OF HEALTH PROFESSIONS .". In: KNJ Dec. 2011; vol.41:2. Impress Communications; Submitted. Abstract

Health care professionals are absorbed daily in the practices of their professional areas of specialization. Pediatricians, for example spend most of their time catering to the needs of children, while nurses, pharmacists and dentists in their own areas. Medical Educators, however, spend their time catering to the educational needs of all health care professionals, whatever their specialization. A recent area of concern in the medical education curricula has been the inclusion of the topic

MUTUKU DRNZIMBIBERNARD, KIBET DRMOINDISTEPHEN, P PROFPOKHARIYALGANESH. "Stephen Moindi Kibet, G.P. Pokhariyal and B.M. Nzimbi, W_2-Recurrent LP-Sasakian manifold, Universal Journal of Mathematics and Mathematical Sciences(UMMS) accepted in May 2012. Paper under review.". In: E.A.M. J. 58: 401-404, 1981. Universal Journal of Mathematics and Mathematical Sciences(UMMS); Submitted. Abstract
Aminoglutethimide (AG) 500 mg was administered orally to four normal volunteers and eight patients undergoing treatment for metastatic breast cancer. In each subject the acetylator phenotype was established from the monoacetyldapsone (MADDS)/dapsone (DDS) ratio. Acetylaminoglutethimide (acetylAG) rapidly appeared in the plasma and its disposition paralleled that of AG. A close relationship (P less than 0.01) was observed between the acetyl AG/AG and MADDS/DDS ratio suggesting that AG may undergo polymorphic acetylation like DDS. AG half-life was 19.5 +/- 7.7 h in seven fast acetylators of DDS and 12.6 +/- 2.3 h in five slow acetylators and its apparent metabolic clearance was significantly (P less than 0.01) related to the acetylAG/AG ratio. Over 48 h the fast acetylators excreted 7.7 +/- 4.4% of the administered AG dose in the urine as unchanged AG as compared to 12.4 +/- 2.8% in slow acetylators. A much smaller fraction of the dose was excreted as acetylAG: 3.6 +/- 1.5% by fast and 1.9 +/- 1.0% by slow acetylators respectively. After 7 days treatment with AG at an accepted clinical dose regimen to the eight patients there were significant reductions in the half-lives of AG (P less than 0.01) and acetylAG (P less than 0.01) and a trend (0.1 greater than P greater than 0.05) towards reduction of the acetylAG/AG ratio which became significant (P less than 0.05) if the one patient on a known enzyme inducer was omitted. The mean apparent volume of distribution was not significantly (P greater than 0.1) altered but the mean apparent systemic clearance of AG was increased (P less than 0.05). These changes are attributed to auto-induction of oxidative enzymes involved in AG metabolism.
MUTUKU DRNZIMBIBERNARD, KIBET DRMOINDISTEPHEN, P PROFPOKHARIYALGANESH. "Stephen Moindi Kibet, G.P. Pokhariyal and B.M. Nzimbi, W_2-Recurrent LP-Sasakian manifold, Universal Journal of Mathematics and Mathematical Sciences(UMMS) accepted in May 2012. Paper under review.". In: Asynchronous Content Development Workshop,Kenya Wildlife Service Training Institute, Naivasha, Kenya,31st March 2004. Universal Journal of Mathematics and Mathematical Sciences(UMMS); Submitted.
ASIAGO DORCAH, GATHII ALICE, Ngesu LM, Gunga SO, Gakuru A, Kahigi C, Nyaga VK, Oundo MB, Kamoyo JM, ADEGBORO JS, others. "TEACHERS’PERCEPTIONS OF PERFORMANCE APPRAISAL PRACTICES IN PUBLIC SECONDARY SCHOOLS IN LIMURU DISTRICT.". Submitted. Abstract
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Mutua M, Kinuthia W, Otieno NE, Muriuki JM, Lange CN, Muchai M, Ingrisch S, Oyieke H, Lampe KH. "Type specimen of the insect order Coleoptera in the scientific collection of the National Museums of Kenya, Nairobi.". Submitted. Abstract
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{Capdevielle-Dulac MZ, Balliau T, Ru BL, Kaiser-Arnauld L, Juma G, Maina E, Calatayud P-A. "The use of salivary $\alpha$-amylase as an evolutionary solution to host selection in parasitoids 2.". Submitted. Abstract
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KAGURE PROFKARANIANNE. "Utrasound findings; Their Importance and their Nursing and Medical Education Implication- The Case of Ectopic Pregnancies.". In: Kenya Nursing Journal, 38 (1) 55-59. Dr. Onditi Elias G.D, Prof. Anna K. Karani & Prof. Simon Kangethe; Submitted. Abstract

Background: Utrasound  technology continues advancing in techniques and diagnosis. It remains a field of specialists where nurses and other health workers are uneducated on it. Objectives: Determine pattern of ultrasound findings in ectopic pregnancy, involvement of nursing staff, determine medical education implications.Design: Retrospective, prospective and on-going study over 8 year period. Focus group discussions with nursing and medical education analysts. Setting: Memorial Hospital Eldoret, Kenya.Participants - 81 patients with ectopic pregnancy diagnosed by ultrasound.Results: Age range 19-39 years - 34.6% Unruptured ectopic pregnancy - 44.5%, Ruptured 43.2%, chronic leaking 2.3%.Conclusion: Ultrasound aids diagnosis and can grade type of pregnancy. Need to demystify science to nurses, clinical officers and other health workers.Recommendation: Medical education to include ultrasound to existing curriculaspecifying roles by health workers. Use participatory teaching methods for ultrasound technology. 

KYALE DRKISUMBIBERNINA, M DRWAKIAGAJOHN. "Wakiaga J.M and Kisumbi B.K: In-vitro colour changes of resin composites in beverages. Journal of Dental Research.". In: Journal of Dental Research. University of Nairobi Press; Submitted. Abstract
This study was done to determine the nature of utilization of dental auxiliaries and medical emergencies in private dental surgeries in Kenya. A self administering questionnaire with pre-paid postage was mailed to 138 dentists. 27.5% responded. 81.6% used dental auxiliaries and the main reason was to improve efficiency in managing patients. 93.5% of the auxiliaries were on job trained secondary school graduates. 63.2% of the respondents delegated duties which were mainly non-clinical. 26.3% did not delegate any duties. In a descending order, the reasons for non delegation were: that it would be risky to patients, not allowed by law, they did not find it necessary and that auxiliaries were not held responsible if something went wrong. The main duties delegated to the auxiliaries were cleaning of instruments and sterilization, mixing of restorative materials and preparing amalgam. Delegation was done primarily based on auxiliaries capability to perform the procedure and meet the set standards. 57.9% indicated that they rarely encountered medical emergencies. Syncope was the commonest emergency encountered. 72.7% indicated that auxiliaries could not handle medical emergencies because they were not trained. It is concluded that most dentists did not delegate clinical duties to dental auxiliaries and medical emergencies were rare.
KYALE DRKISUMBIBERNINA, M DRWAKIAGAJOHN. "Wakiaga J.M., Maina S.W., Kisumbi B.K. : Incidence of the second Canal in the upper Second Premolar. (Journal of Dental Research).". In: Journal of Dental Research. Taylor & Francis; Submitted. Abstract
OBJECTIVES: The aim was to study dimensional time-dependence of resin/ionomer formulations from 5 min age to one month and to separate out the intrinsic setting shrinkage and hygroscopic expansion effects, by using non-aqueous and aqueous storage media, respectively. METHODS: Materials studied included: A: resin-, B: metal- and C: polyphosphonate-modified glass-ionomer cements [GICs]; and controls of D: poly-acid modified composite [compomer]; and E: resin-composite. Separate specimen groups (n = 5) were stored in different storage-media: (i) silicone fluid; (ii) de-ionized water. Experiments were repeated at 23 and 37 degrees C. Volumetric changes of specimens (4 mm diameter x 6 mm height) were obtained via accurate mass measurements (to 10(-4) g), using Archimedes principle, with silicone or water also used as the Archimedean fluid. These measurements were made periodically over a 30 day period, post fabrication. RESULTS: In silicone at 23 degrees C, all materials underwent further gradual intrinsic shrinkage (after 5 min from mix). This was highly significant (p < 0.05) for the RM-GIC (A). At 37 degrees C, however the RM-GIC expanded, indicating that its cure is temperature-sensitive. In water, at 23 and 37 degrees C, the shrinkage was either partially offset (materials C, D, E), or replaced by appreciable expansions (materials A and B). Differences between RM-GIC (A) and MM-GIC (B) were significant (p < 0.05). SIGNIFICANCE: The deployment of dual storage media made an important contribution to the separate analysis of the volumetric changes due to the on-going setting chemistry in these systems and the time-dependent effects of an aqueous environment.
KYALE DRKISUMBIBERNINA, M DRWAKIAGAJOHN. "Wakiaga J.M., Maina S.W., Kisumbi B.K. : Incidence of the second Canal in the upper Second Premolar. (Journal of Dental Research).". In: Journal of Dental Research. University of Nairobi Press; Submitted. Abstract
This study was done to determine the nature of utilization of dental auxiliaries and medical emergencies in private dental surgeries in Kenya. A self administering questionnaire with pre-paid postage was mailed to 138 dentists. 27.5% responded. 81.6% used dental auxiliaries and the main reason was to improve efficiency in managing patients. 93.5% of the auxiliaries were on job trained secondary school graduates. 63.2% of the respondents delegated duties which were mainly non-clinical. 26.3% did not delegate any duties. In a descending order, the reasons for non delegation were: that it would be risky to patients, not allowed by law, they did not find it necessary and that auxiliaries were not held responsible if something went wrong. The main duties delegated to the auxiliaries were cleaning of instruments and sterilization, mixing of restorative materials and preparing amalgam. Delegation was done primarily based on auxiliaries capability to perform the procedure and meet the set standards. 57.9% indicated that they rarely encountered medical emergencies. Syncope was the commonest emergency encountered. 72.7% indicated that auxiliaries could not handle medical emergencies because they were not trained. It is concluded that most dentists did not delegate clinical duties to dental auxiliaries and medical emergencies were rare.
In Press
S. Z, G. C, I. V, G. B, D.M. H, K.M. M, J.R. B. "Adaptive radiation of the endemic Alcolapia cichlids of the East African soda lakes: genetic and morphological perspectives." Journal of Evolutionary Biology. In Press.
Kamugisha M, Mutembei HM TT. "Assessing the value of agroforestry and food security among households in Isingiro District, South-Western Uganda." International Journal of Sustainable Development and World Ecology. In Press:1-16.
Etenyi JO, Okalebo FA, S.A. Opanga, K. A. Sinei, Osanjo GO, Kurdi A, Goodman B. Comparison of zidovudine and tenofovir based regimens with regard to quality of life and prevalence of syptoms in HIV patients in Kenya. Prague; In Press.
Kyule MD, Oyamo M. "Cultural resource management in Kenya: a case for legislation review.". In: Kenya from Independence to early 21st century. Nairobi: Nairobi University Press; In Press. Abstract

This paper builds a case for a reconsideration of Kenya’s legislation that relates to cultural and societal heritage resources management by briefly revisiting the circumstances that informed the enactment of the related laws. We present the view that existing legislation has tended to serve corporate, multinational and foreign interests at the expense of local and national interests, and that although these Acts may have somewhat served the country in the past, the legislations have turned the cultural heritage management in Kenya into a lame duck framework of abstractions of policy matters, that are irrelevant and unresponsive to changing local and international circumstances. We highlight contradictions between and within varied Acts, and offer suggestions for remedy that are geared toward the development of a cultural management policy with local ownership and universal compatibility.

Kamugisha M, Mutembei HM TT. "Determining Household and Farm Level Governance Factors affecting transition to household food security in Isingiro District, South-Western Uganda." African Journal of Food, Agriculture, Nutrition and Development. In Press.
Kemoli AM. "Dilemma of managing multi-surface dental caries in the primary dentition using the atraumatic restorative treatment: renaissance or dimming hope." East Afr Med J . In Press. Abstract

Background: Alot of research work has been carried out to determine the effectiveness of using atraumatic restorative treatment (ART) in the management of dental caries, but there are still unresolved issues surrounding the use of the technique particularly in very large carious lesions.
Objective: To determine the current survival rates of multi-surface ARTrestorations placed in the primary dentition and any consequences to the restored tooth after premature loss of the restoration.
Study selection: Using a set of specific key words, a Pubmed/Medline search was carried out to retrieve all publications on ARTrestorations placed in primary teeth in the period January 2000 to December 2011. Only publications whose studies had multi-surface ARTrestorations as an item of study were retrieved and relevant data extracted.
Data synthesis: Twelve studies contained in 12 publications fulfilled the selection criteria and were included in the study. The selected publications were analysed by the author to establish the study follow-up period and the survival rate of the multi-surface ARTrestorations for the different follow-up periods. Further information was adduced on any other effects of restoration on the tooth after premature loss of the restoration.
Results: The search findings indicated that the survival rate for most of the multi-surface restorations were generally very low. Further, there were indications that even after the premature loss of the ARTrestorations, most of the affected teeth survived for the period of the study with a number of them having shown no signs of secondary caries or associated dental abscessees.
Conclusion: While the survival rates of multi-surface ARTrestorations in the studies documenetd in the review were low, the ART restorations appeared to provide some beneficial effects to the retention-longevity of the restored tooth even after their premature loss.

Nzimbi BM, Kiratu BN, Sitati IN, Kipkemoi ST. "Remarks on the Murray-von Neumann equivalence of projections." International Journal of Pure and Applied Mathematics(IJPMAS)-accepted June 6, 2016. In Press.
MUTUKU DRNZIMBIBERNARD, KIBET DRMOINDISTEPHEN, P PROFPOKHARIYALGANESH. "W_4-Curvature tensor on a A-Einstein Sasakian manifold." Global Journal of Theoretical and Applied Mathematical Sciences(GJTAMS). In Press. Abstract

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2022
Vannevel V, Vogel JP, Pattinson RC, Adanu R, Charantimath U, Goudar SS, Gwako G, Kavi A, Maya E, Osoti A, Pujar Y, Qureshi ZP, Rulisa S, Botha T, Oladapo OT. "Antenatal Doppler screening for fetuses at risk of adverse outcomes: a multicountry cohort study of the prevalence of abnormal resistance index in low-risk pregnant women." BMJ Open. 2022;12(3):e053622. Abstract

Few interventions exist to address the high burden of stillbirths in apparently healthy pregnant women in low- and middle-income countries (LMICs). To establish whether a trial on the impact of routine Doppler screening in a low-risk obstetric population is warranted, we determined the prevalence of abnormal fetal umbilical artery resistance indices among low-risk pregnant women using a low-cost Doppler device in five LMICs.

QURESHI ZAHIDA, Jamner A, Filippi V, Gwako G, Osoti A, Mehrtash H, Baguiya A, Bello FA, Compaoré R, Gadama L, Kim CR, Msusa AT, Tunçalp Ӧ, Calvert C. "Level and determinants of contraceptive uptake among women attending facilities with abortion-related complications in East and Southern Africa." Int J Gynaecol Obstet. 2022;156 Suppl 1:27-35. Abstract

To investigate the level and determinants of nonreceipt of contraception among women admitted to facilities with abortion-related complications in East and Southern Africa.

Beydon N, Ferkol T, Harris AL, Colas M, Davis SD, Haarman E, Hogg C, Kilbride E, Kouis P, Kuehni CE, Latzin P, Marangu D, Marthin J, Nielsen KG, Robinson P, Rumman N, Rutter M, Walker W, Lucas JS. "An international survey on nasal nitric oxide measurement practices for the diagnosis of primary ciliary dyskinesia." ERJ Open Res. 2022;8(2). Abstract

Nasal nitric oxide (nNO) measurements are used in the assessment of patients suspected of having primary ciliary dyskinesia (PCD), but recommendations for performing such measurements have not focused on children and do not include all current practices. To guide the development of a European Respiratory Society-supported technical standard for nNO measurement in children, an international online survey was conducted to better understand current measurement practices among providers involved in PCD diagnostics. 78 professionals responded, representing 65 centres across 18 countries, mainly in Europe and North America. Nearly all centres measured nNO in children and more than half performed measurements before 5 years of age. The test was often postponed in children with signs of acute airway infection. In Europe, the electrochemical technique was more frequently used than chemiluminescence. A similar proportion of centres performed measurements during exhalation against a resistance (49 out of 65) or during tidal breathing (50 out of 65); 15 centres used only exhalation against a resistance and 15 used only tidal breathing. The cut-off values used to discriminate PCD were consistent across centres using chemiluminescence analysers; these centres reported results as an output (nL·min). Cut-off values were highly variable across centres using electrochemical devices, and nNO concentrations were typically reported as ppb. This survey is the first to determine real-world use of nNO measurements globally and revealed remarkable variability in methodology, equipment and interpretation. These findings will help standardise methods and training.

Githaka NW, Kanduma EG, Wieland B, Darghouth MA, Bishop RP. "Acaricide resistance in livestock ticks infesting cattle in Africa: Current status and potential mitigation strategies." Curr Res Parasitol Vector Borne Dis. 2022;2:100090. Abstract

In many African countries, tick control has recently been the responsibility of resource-poor farmers rather than central government veterinary departments. This has led to an increase in acaricide resistance, threatening the welfare of livestock farmers in sub-Saharan Africa. Resistance has evolved to the three classes of acaricides used most extensively in the continent, namely fourth-generation synthetic pyrethroids (SP), organophosphates (OP) and amidines (AM), in virtually all countries in which they have been deployed across the globe. Most current data are derived from research in Australia and Latin America, with the majority of studies on acaricide resistance in Africa performed in South Africa. There is also limited recent research from West Africa and Uganda. These studies confirm that acaricide resistance in cattle ticks is a major problem in Africa. Resistance is most frequently directly assayed in ticks using the larval packet test (LPT) that is endorsed by FAO, but such tests require a specialist tick-rearing laboratory and are relatively time consuming. To date they have only been used on a limited scale in Africa and resistance is often still inferred from tick numbers on animals. Rapid tests for resistance in ticks, would be better than the LPT and are theoretically possible to develop. However, these are not yet available. Resistance can be mitigated through integrated control strategies, comprising a combination of methods, including acaricide class rotation or co-formulations, ethnoveterinary practices, vaccination against ticks and modified land management use by cattle, with the goal of minimising the number of acaricide applications required per year. There are data suggesting that small-scale farmers in Africa are often unaware of the chemical differences between different acaricide brands and use these products at concentrations other than those recommended by the manufacturers, or in incorrect rotations or combinations of the different classes of chemicals on the market. There is an urgent need for a more evidence-based approach to acaricide usage in small-scale livestock systems in Africa, including direct measurements of resistance levels, combined with better education of farmers regarding acaricide products and how they should be deployed for control of livestock ticks.

Plisnier P-D, Kayanda R, MacIntyre S, Obiero K, Okello W, Vodacek A, Cocquyt C, Abegaz H, Achieng A, Akonkwa B, Albrecht C, Balagizi C, Barasa J, Abel Bashonga R, Bashonga Bishobibiri A, Bootsma H, Borges AV, Chavula G, Dadi T, De Keyzer ELR, Doran PJ, Gabagambi N, Gatare R, Gemmell A, Getahun A, Haambiya LH, Higgins SN, Hyangya BL, Irvine K, Isumbisho M, Jonasse C, Katongo C, Katsev S, Keyombe J, Kimirei I, Kisekelwa T, Kishe M, Otoung A. Koding S, Kolding J, Kraemer BM, Limbu P, Lomodei E, Mahongo SB, Malala J, Mbabazi S, Masilya PM, McCandless M, Medard M, Migeni Ajode Z, Mrosso HD, Mudakikwa ER, Mulimbwa N'sibula, Mushagalusa Déo, Muvundja FA, Nankabirwa A, Nahimana D, Ngatunga BP, Ngochera M, Nicholson S, Nshombo M, Ntakimazi G, Nyamweya C, Ikwaput Nyeko J, Olago D, Olbamo T, O'Reilly CM, Pasche N, Phiri H, Raasakka N, Salyani A, Sibomana C, Silsbe GM, Smith S, Sterner RW, Thiery W, Tuyisenge J, Van der Knaap M, Van Steenberge M, van Zwieten PAM, Verheyen E, Wakjira M, Walakira J, Ndeo Wembo O, Lawrence T. "Need for harmonized long-term multi-lake monitoring of African Great Lakes.". 2022. AbstractWebsite

To ensure the long-term sustainable use of African Great Lakes (AGL), and to better understand the functioning of these ecosystems, authorities, managers and scientists need regularly collected scientific data and information of key environmental indicators over multi-years to make informed decisions. Monitoring is regularly conducted at some sites across AGL; while at others sites, it is rare or conducted irregularly in response to sporadic funding or short-term projects/studies. Managers and scientists working on the AGL thus often lack critical long-term data to evaluate and gauge ongoing changes. Hence, we propose a multi-lake approach to harmonize data collection modalities for better understanding of regional and global environmental impacts on AGL. Climate variability has had strong impacts on all AGL in the recent past. Although these lakes have specific characteristics, their limnological cycles show many similarities. Because different anthropogenic pressures take place at the different AGL, harmonized multi-lake monitoring will provide comparable data to address the main drivers of concern (climate versus regional anthropogenic impact). To realize harmonized long-term multi-lake monitoring, the approach will need: (1) support of a wide community of researchers and managers; (2) political goodwill towards a common goal for such monitoring; and (3) sufficient capacity (e.g., institutional, financial, human and logistic resources) for its implementation. This paper presents an assessment of the state of monitoring the AGL and possible approaches to realize a long-term, multi-lake harmonized monitoring strategy. Key parameters are proposed. The support of national and regional authorities is necessary as each AGL crosses international boundaries.

Cohen AS, Campisano CJ, Arrowsmith RJ, Asrat A, Beck CC, Behrensmeyer AK, Deino AL, Feibel CS, Foerster V, Kingston JD, Lamb HF, Lowenstein TK, Lupien RL, Muiruri V, Olago DO, Owen BR, Potts R, Russell JM, Schaebitz F, Stone JR, Trauth MH, Yost CL. "Reconstructing the Environmental Context of Human Origins in Eastern Africa Through Scientific Drilling." Annual Review of Earth and Planetary SciencesAnnual Review of Earth and Planetary Sciences. 2022. AbstractWebsite

Paleoanthropologists have long speculated about the role of environmental change in shaping human evolution in Africa. In recent years, drill cores of late Neogene lacustrine sedimentary rocks have yielded valuable high-resolution records of climatic and ecosystem change. Eastern African Rift sediments (primarily lake beds) provide an extraordinary range of data in close proximity to important fossil hominin and archaeological sites, allowing critical study of hypotheses that connect environmental history and hominin evolution. We review recent drill-core studies spanning the Plio?Pleistocene boundary (an interval of hominin diversification, including the earliest members of our genus Homo and the oldest stone tools), and the Mid?Upper Pleistocene (spanning the origin of Homo sapiens in Africa and our early technological and dispersal history). Proposed drilling of Africa's oldest lakes promises to extend such records back to the late Miocene. ?High-resolution paleoenvironmental records are critical for understanding external drivers of human evolution. ?African lake basin drill cores play a critical role in enhancing hominin paleoenvironmental records given their continuity and proximity to key paleoanthropological sites. ?The oldest African lakes have the potential to reveal a comprehensive paleoenvironmental context for the entire late Neogene history of hominin evolution. Expected final online publication date for the Annual Review of Earth and Planetary Sciences, Volume 50 is May 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.Paleoanthropologists have long speculated about the role of environmental change in shaping human evolution in Africa. In recent years, drill cores of late Neogene lacustrine sedimentary rocks have yielded valuable high-resolution records of climatic and ecosystem change. Eastern African Rift sediments (primarily lake beds) provide an extraordinary range of data in close proximity to important fossil hominin and archaeological sites, allowing critical study of hypotheses that connect environmental history and hominin evolution. We review recent drill-core studies spanning the Plio?Pleistocene boundary (an interval of hominin diversification, including the earliest members of our genus Homo and the oldest stone tools), and the Mid?Upper Pleistocene (spanning the origin of Homo sapiens in Africa and our early technological and dispersal history). Proposed drilling of Africa's oldest lakes promises to extend such records back to the late Miocene. ?High-resolution paleoenvironmental records are critical for understanding external drivers of human evolution. ?African lake basin drill cores play a critical role in enhancing hominin paleoenvironmental records given their continuity and proximity to key paleoanthropological sites. ?The oldest African lakes have the potential to reveal a comprehensive paleoenvironmental context for the entire late Neogene history of hominin evolution. Expected final online publication date for the Annual Review of Earth and Planetary Sciences, Volume 50 is May 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

Kithure JGN. ). Statistics for Chemists (Questions and Answers). Moldova Europe: LAP LAMBERT Academic Publishing, trade mark of Dodo Books Indian Ocean Ltd., member of the OmniScriptum S.R.L Publishing group. Str. A. Russo 15, of 61, Chisinau-2068, Republic of Moldova Europe. Printed by Printforce, United Kingdom. ISBN: 978-620-0-5490; 2022.preface.pdf
Mbindyo SN, Abuom TO, KITAA JAFREDMA. "Antibiotic Resistance and Stewardship in Small Animal Practice-A Review." Journal of Veterinary Medicine and Animal Sciences. 2022;5(1):1102.
Nguli M, Gatari MJ, Keith Shepherd, Njenga L, Boman J. "Assessment of Essential Micronutrient Levels in Common Beans (Phaseolus vulgaris) in Kenya by Total reflection X-ray Fluorescence (TXRF)." X-Ray Spectrometry. 2022;2022. Abstract

This study reports concentrations of Mn, Fe, Cu and Zn analysed from Kenyan bean grains and leaves using Total Reflection X-ray Fluorescence (TXRF) and Inductively Coupled Plasma – Optical Emission Spectrometry (ICP-OES) methods. Samples of fresh bean leaves and 7 species of dry grains were collected from small scale farmers in Machakos and Kiambu counties. They were delivered to the laboratory where bean grain samples for TXRF analysis were prepared and leaves for both TXRF and ICP-OES. Standard methods of sample preparation successfully tested and used by other authors were used, Average elemental concentrations of the samples were then compared with established sufficiency values mainly given in ranges. Bean leaves from Muguga had sufficient Mn, Ni and Cu concentrations while 6% of the samples had Zn concentrations higher than the sufficiency range. Fe concentrations were consistently high with 97% of the samples having concentrations that were higher than the sufficiency range. No deficiencies were observed from bean leaves from Kyevaluki. For dry bean grains, deficiencies were observed in which four species were found to be deficient in Mn while Zn deficiency was observed in all the species. Fe concentrations were above the sufficiency ranges for all the species but not to toxic levels and 29% of the samples had Cu concentrations that were within the sufficiency range. The obtained data will be essential information for both farmers and policy makers on the nutritional quality of beans in the sampled areas. However, further studies are recommended including soil analysis and elemental bioavailability for full nutritional assessment. Keywords: ICP-OES, hidden hunger, mortality rate, cognitive development, bioavailable

Nakami WN, Nguhiu-Mwangi J, Kipyegon AN’eno, Ogugo M, Muteti C, Kemp S. "Comparative Efficiency for in vitro Transfection of Goat Undifferentiated Spermatogonia Using Lipofectamine Reagents and Electroporation." Stem Cells and Cloning: Advances and Applications. 2022;15:11-20.
Nakami WN, Nguhiu-Mwangi J, Kipyegon AN’eno, Ogugo M, Muteti C, Stephen K. "Comparative Efficiency for in vitro Transfection of Goat Undifferentiated Spermatogonia Using Lipofectamine Reagents and Electroporation." Stem Cells and Cloning: Advances and Applications. 2022;15:11. Abstract

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Nakami WN, Nguhiu-Mwangi J, Kipyegon AN’eno, Ogugo M, Muteti C, Stephen K. "Comparative Efficiency for in vitro Transfection of Goat Undifferentiated Spermatogonia Using Lipofectamine Reagents and Electroporation." Stem Cells and Cloning: Advances and Applications. 2022;15:11.
Hashim I, Onyari JM, Omosa LK, Maru SM, Nchiozem-Ngnitedem V-A, Karpoormath R. "Conglomeratin: A new antibacterial flavonol derivative from Macaranga conglomerata Brenan (Euphorbiaceae)." Natural Products Research. 2022:https://doi.org/10.1080/14786419.2022.2061481.hashim_et_al_2022_natural_products_research.pdf
Kimaru J, Mutembei H.M MJK. "Cost-benefit analysis of Hay production in different farm sizes in Kajiado County." East African Agricultural and Forestry Journal. 2022;85(3):1-4.
Ng'etich DK, Bett RC, GACHUIRI CHARLESK, Kibegwa FM. "Diversity of Gut Methanogens and Functional Enzymes Associated With Methane Metabolism in Smallholder Dairy Cattle." research square . 2022;2022.
Malenje EM, Missohou A, Tebug SF, König EZ, Jung’a JO, Bett RC, Marshall K. "Economic Analysis of Smallholder Dairy Cattle Enterprises In Senegal." research square . 2022.
Malenje EM, Ayao Missohou SFT, König EZ, Jung’a JO, Bett RC, Marshall K. "Economic Analysis of Smallholder Dairy Cattle Enterprises In Senegal.". 2022.
Wanyama HN, Karega LN, Chimoita EL. "Effect of Use of Tacit Knowledge Transfer Techniques on Organizational Performance of Kenya Agricultural and Livestock Research Organization Researchers." Journal of Agricultural Extension, Economics &Sociology. 2022;0(10)(0(10): 492-502):DOI: 10.9734/AJAEES/2022/v40i1031103.effectof_use_of_tacit_knowledgetransfer_techniques.pdf
Wafula, WM, Wasonga OV, Koech OK, Kibet S. "Factors influencing migration and settlement of pastoralists in Nairobi City, Kenya." Pastoralism: Research, Policy and Practice. 2022;12(2).
Wafula WM, Wasonga OV, Koech OK, Kibet S. "Factors influencing migration and settlement of pastoralists in Nairobi City, Kenya." Pastoralism: Research, Policy and Practice. 2022;12(1):1-14.
Runtuwene LR, Sathirapongsasuti N, Srisawat R, Komalamisra N, Tuda JSB, EMongan A, Aboge GO. "Global research alliance in infectious disease: a collaborative effort to combat infectious diseases through dissemination of portable sequencing." BMC Research Notes . 2022;(2022) 15:44 .
Simon PB, Junga JO, Getinet Mekuriaw Tarekegn, Machuka E, Christian Keambou Tiambo, Kabange D, M KM, Dieudinné RVK, Ochieng JW, Pelle R. "Haplotype analysis of the mitochondrial DNA d-loop region reveals the maternal origin and historical dynamics among the indigenous goat populations in east and west of the Democratic Republic of Congo." Ecology and evolution. 2022;13(2):e8713.
Heng YY, Asad I, Coleman B, Menard L, Benki-Nugent S, Faridah H Were, Karr CJ, McHenry MS. "Heavy metals and neurodevelopment of children in low and middle-income countries: A systematic review." PLOS ONE. 2022;17(3).
Kairania R, Onyango-Ouma W, Ondicho TG, Kigozi G. "HIV status disclosure and antiretroviral therapy adherence among children in Masaka region, Uganda." African Journal of AIDS Research. 2022;21(3):1-10.
Wafula KM, Karanja NN, Karuku GN, Esilaba AO. "In-situ Water harvesting technologies and fertilizer rates increase maize and bean yield in the Semi-Arid Katumani, Kenya." Tropical and Subtropical Agroecosystems . 2022;25(3).
Misango, G.V, Nzuma, M.J., Irungu, L.W., Kassie, M. "Intensity of adoption of integrated pest management practices in Rwanda: A fractional logit approach." Heliyon. 2022;https://doi.org/10.1016/j.heliyon.2022.e08735.
J.K.M., A.K., M. DN, K JGN, S.O.W, A.G.W. "Microbial Fuel Cell Bio-Remediation of Lambda Cyhalothrin, Malathion and Chlorpyrifos on Loam Soil Inoculated with Bio-Slurry. ." American Journal of Environment and Climate. 2022;1(1):34-41.
Kariuki MI, Mwangi JM, Muturi PG. "Moderating effect of age in the relationship between debt literacy and indebtedness of formal sector employees in Kenya." International Journal of Scientific and Research Publications (IJSRP). 2022;12(7):532-44.
Obonyo FO, Maingi N, Samuel Maina Githigia, Kimeli P, Nyaboga EN. "Occurrence of serum antibodies to Toxoplasma gondii and associated risk factors in donkeys from central Kenya." Tropical Animal Health and Production. 2022;54(1):1-11.
Obonyo  FO, Maingi N, Githigia  SM, Kimeli P, Nyaboga EN. "Occurrence of serum antibodies to Toxoplasma gondii and associated risk factors in donkeys from central Kenya." Tropical Animal Health and Production. 2022;54(1):77.
Barre A, Karanja DN, Bebora LC, Gitao CG. "Prevalence of Brucellosis in Camel Slaughter Population in Garissa County, Kenya. ." OSR Journal of Agriculture and Veterinary Science. 2022;15(1):39-46.
Kamuti NM, Mbuthia, P.G., Waruiru, R.M., Githigia SM, Keya EA. "Prevalence, Etiology and Risk Factors Associated with Occurrence of Canine Cutaneous Myiasis in Kitui County, Kenya." Hindawi Journal of Veterinary Medicine International. 2022.
Kamuti NM, Mbuthia PG, Waruiru RM, Githigia SM, Keya EA. "Prevalence, etiology and risk factors associated with occurrence of canine cutaneous myiasis in Kitui County, Kenya." Hindawi Veterinary Medicine International. 2022;Vol. 2022(ID 5699060):9 pages .
Tangus CJ, Chege JN, Karanja DN, Gachuiri CK. "The prevalence,intensity and spectrum of gastrointestinal parasites in selected sheep farms in Kasarani sub-county, Nairobi County, Kenya." to Hindawi Journal of veterinary medicine international. 2022.
Kimani PK´ethe, Mbuge D, Gitau AN. "Properties of Nonwoven Fabrics Containing Immobilized Superabsorbent Polymer Particles for Air Conditioning in Grain Dryers, Applied Engineering in Agriculture." American Society of Agricultural and Biological Engineers. 2022;38(2)(ISSN 0883-8542).
Mbayaki CW, Karuku GN. "Soil hydraulic properties of a chromic Luvisol in Katumani, Kenya." Tropical and Subtropical Agroecosystems . 2022;25(3).
K G, T M, J N, MO O. "Studies on the ethnopharmacology, antimicrobial activity, and toxicity of Catha edulis (Vahl.) Endl., in Sprague Dawley rats.". 2022;([version 1; peer review: awaiting peer review]. F1000 Research 2022, 11:286):https://doi.org/10.12688/f1000research.109243.1.
Osiro OA, Kariuki DK, Gathece LW. "Synthesis and characterisation of ionomer-type cements from alkaline activated kaolinite." Non-crystalline solids: X. 2022;doi: https://doi.org/10.1016/j.nocx.2021.100079.
Rop K, Karuku GN, Mbui D. "Synthesis and characterization of biodegradable cellulose-based polymer hydrogel.". In: Nanotechnology in Paper and Wood Engineering Fundamentals, Challenges and Applications. Amsterdam: Elsevier Radarweg 29, PO Box 211, 1000 AE Amsterdam, Netherlands The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, United Kingdom 50 Hampshire Street, 5th Floor, Cambridge, MA 02139, United States Copyright © 2022 Elsevier Inc. All rights res; 2022.
Osiro OO, Kariuki DK, Joyce K G. "Synthesis and Characterization of Ionomer-type Cements from Alkalin-Activated Kaolinite." Journal of Non-Crystalline Solids-X. 2022;13(100079):2-10.
Masila VM, Ndakala AJ, Midiwo JO, Byamukama R, Kamau RW, Kumarihamy M, Muhammad I. "Synthesis of a pyrrolidine derivative of a carvotacetone and monoterpenes for anti-methicillin-resistant Staphylococcus aureus and anti-cryptococcal properties." Natural Product Research. 2022;36(9):2321-2328.
Githaka NW, Kanduma EG, Wieland B, Darghouth MA, Bishop RP. "Acaricide resistance in livestock ticks infesting cattle in Africa: Current status and potential mitigation strategies." Current Research in Parasitology & Vector-Borne Diseases. 2022:100090. Abstract
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Lee AC, Peng B, Du K, Kung H-H, Monserrat B, Cheong S-W, Won CJ, Blumberg G. "Chiral Electronic Excitations in a Quasi-2D Rashba System BiTeI." arXiv preprint arXiv:2202.03569. 2022. Abstract
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Lee AC, Peng B, Du K, Kung H-H, Monserrat B, Cheong SW, Won CJ, Blumberg G. "Chiral electronic excitations in the quasi-two-dimensional Rashba system BiTeI." Physical Review B. 2022;105:L161105. Abstract
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Marufu C, Kisumbi BK, Osiro OA, Otieno FO. "Effect of finishing protocols and staining solutions on color stability of dental resin composites." Clinical and Experimental Dental Research. 2022;8:561-570. Abstract
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Zhang Q, Nam J-S, Han J, Datta S, Wei N, Ding E-X, Hussain A, Ahmad S, Skakalova V, Khan AT, others. "Large-Diameter Carbon Nanotube Transparent Conductor Overcoming Performance–Yield Tradeoff." Advanced Functional Materials. 2022;32:2103397. Abstract
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Lepore CM, Kamau L, Kanduma E. "Molecular Prevalence of Entamoeba Species among Diarrheal Patients in Eastern Kenya." European Journal of Biology and Biotechnology. 2022;3:39-46. Abstract
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Githaka NW, Bishop RP, Šlapeta J, Emery D, Nguu EK, Kanduma EG. "Molecular survey of Babesia parasites in Kenya: first detailed report on occurrence of Babesia bovis in cattle." Parasites & vectors. 2022;15:1-11. Abstract
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Zhang J, Peng B, Kim S, Monifi F, Jiang X, Li Y, Yu P, Liu L, Liu Y-xi, Alu A, others. "Optomechanical dissipative solitons (vol 600, pg 75, 2021)." NATURE. 2022. Abstract
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Zhang J, Peng B, Kim S, Monifi F, Jiang X, Li Y, Yu P, Liu L, Liu Y-xi, Alù A, others. "Publisher Correction: Optomechanical dissipative solitons." Nature. 2022. Abstract
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2021
Faris AA, Akuon PO, Kalecha VO. "BER Performance of SSK Sequence Modulation.". In: IEEE AFRICON 2021. Arusha, Tanzania; 2021.
Koteng POG, Ralwala AO. "Assessment of Heat Stress Exposure on Construction Workers in Hot and Humid Environments during the Covid-19 Pandemic Period. .". In: (Re)Setting Built Environment Theory and Practice in a Post-pandemic World: Disrupted Buildings or Design for Disruption. School of Architecture and Building Sciences (SABS) online (virtual) conference, JKUAT; 2021.
Akinyi J, Mwaniki A, Gichamba A, Kariuki D, Chand P, Munene S, Nyakinyua C, Nzangi B, Akinyi V, Betsy M, Cosmas K, Mwangi M. "NanoSatellite Platform for the University of Nairobi (NaSPUoN) Student Project.". In: 72nd International Astronautical Congress (IAC). Dubai, United Arab Emirates (presented online); 2021.
Matara SM, Siriba DN, Kiema JB, Musyoka SM. "Predicting Displacement Effects of Tectonic Movements on the Kenyan Geodetic Reference Frame Network (KENREF) .". In: Working eWeek. Netherlands; 2021.
Umuhoza T, Bulimo WD, Julius Oyugi, Musabyimana JP, Kinengyere AA, Mancuso JD. "Prevalence of human respiratory syncytial virus, parainfluenza and adenoviruses in East Africa Community partner states of Kenya, Tanzania, and Uganda: A systematic review and meta-analysis (2007–2020)." PLOS ONE. 2021;16(4):e0249992-. Abstractjournal.pone_.0249992.pdfjournal.pone_.0249992.pdfWebsite

Background Viruses are responsible for a large proportion of acute respiratory tract infections (ARTIs). Human influenza, parainfluenza, respiratory-syncytial-virus, and adenoviruses are among the leading cause of ARTIs. Epidemiological evidence of those respiratory viruses is limited in the East Africa Community (EAC) region. This review sought to identify the prevalence of respiratory syncytial virus, parainfluenza, and adenoviruses among cases of ARTI in the EAC from 2007 to 2020. Methods A literature search was conducted in Medline, Global Index Medicus, and the grey literature from public health institutions and programs in the EAC. Two independent reviewers performed data extraction. We used a random effects model to pool the prevalence estimate across studies. We assessed heterogeneity with the I2 statistic, and Cochran’s Q test, and further we did subgroup analysis. This review was registered with PROSPERO under registration number CRD42018110186. Results A total of 12 studies met the eligibility criteria for the studies documented from 2007 to 2020. The overall pooled prevalence of adenoviruses was 13% (95% confidence interval [CI]: 6–21, N = 28829), respiratory syncytial virus 11% (95% CI: 7–15, N = 22627), and parainfluenza was 9% (95% CI: 7–11, N = 28363). Pooled prevalence of reported ARTIs, all ages, and locality varied in the included studies. Studies among participants with severe acute respiratory disease had a higher pooled prevalence of all the three viruses. Considerable heterogeneity was noted overall and in subgroup analysis. Conclusion Our findings indicate that human adenoviruses, respiratory syncytial virus and parainfluenza virus are prevalent in Kenya, Tanzania, and Uganda. These three respiratory viruses contribute substantially to ARTIs in the EAC, particularly among those with severe disease and those aged five and above.

Nyumba TO, Sang CC, Olago DO, Marchant R, Waruingi L, Githiora Y, Kago F, Mwangi M, Owira G, Barasa R, Omangi S. "Assessing the ecological impacts of transportation infrastructure development: A reconnaissance study of the Standard Gauge Railway in Kenya." PLOS ONE. 2021;16(1):e0246248-. AbstractWebsite

Transportation infrastructure, such as railways, roads and power lines, contribute to national and regional economic, social and cultural growth and integration. Kenya, with support from the Chinese government, is currently constructing a standard gauge railway (SGR) to support the country’s Vision 2030 development agenda. Although the actual land area affected by the SGR covers only a small proportion along the SGR corridor, a significant proportion of the area supports a wide range of ecologically fragile and important ecosystems in the country, with potential wider impacts. This study used a qualitative content analysis approach to gain an understanding and perceptions of stakeholders on the potential ecological impacts of the interactions between the SGR and the traversed ecological systems in Kenya. Three dominant themes emerged: 1) ecosystem degradation; 2) ecosystem fragmentation; and 3) ecosystem destruction. Ecosystem degradation was the most commonly cited impact at while ecosystem destruction was of the least concern and largely restricted to the physical SGR construction whereas the degradation and fragmentation have a much wider footprint. The construction and operation of the SGR degraded, fragmented and destroyed key ecosystems in the country including water towers, protected areas, community conservancies and wildlife dispersal areas. Therefore, we recommend that project proponents develop sustainable and ecologically sensitive measures to mitigate the key ecosystem impacts.

Tanyi WN, Gachuno O, Odero T, Farquhar C, Kimosop D, Mayi A. "Factors affecting adherence to antiretroviral therapy among children and adolescents living with HIV in the Mbita Sub-County Hospital, Homa Bay- Kenya." Afr Health Sci. 2021;21(Suppl):18-24. AbstractWebsite

Adequate adherence to antiretroviral therapy (ART) is key to the successful treatment of children and adolescents living with HIV. Continuous ART Adherence is the key factor for virologic suppression and stability of the immune system and prevents the occurrence of opportunistic infections. Children and adolescents struggle with adherence to ART for various reasons, including a poor psychosocial support system and clinic attendance.

Dean WH, Buchan J, Gichuhi S, Philippin H, Arunga S, Mukome A, Admassu F, Lewis K, Makupa W, Otiti J, Kim MJ, Macleod D, Cook C, Burton MJ. "Simulation-based surgical education for glaucoma versus conventional training alone: the GLAucoma Simulated Surgery (GLASS) trial. A randomised controlled, educational intervention efficacy trial in Kenya, South Africa, Tanzania, Uganda and Zimbabwe." Br J Ophthalmol. 2021. AbstractWebsite

Background/aim: Glaucoma accounts for 8% of global blindness and surgery remains an important treatment. We aimed to determine the impact of adding simulation-based surgical education for glaucoma.

Methods: We designed a randomised controlled, parallel-group trial. Those assessing outcomes were masked to group assignment. Fifty-one trainee ophthalmologists from six university training institutions in sub-Saharan Africa were enrolled by inclusion criteria of having performed no surgical trabeculectomies and were randomised. Those randomised to the control group received no placebo intervention, but received the training intervention after the initial 12-month follow-up period. The intervention was an intense simulation-based surgical training course over 1 week. The primary outcome measure was overall simulation surgical competency at 3 months.

Results: Twenty-five were assigned to the intervention group and 26 to the control group, with 2 dropouts from the intervention group. Forty-nine were included in the final intention-to-treat analysis. Surgical competence at baseline was comparable between the arms. This increased to 30.4 (76.1%) and 9.8 (24.4%) for the intervention and the control group, respectively, 3 months after the training intervention for the intervention group, a difference of 20.6 points (95% CI 18.3 to 22.9, p<0.001). At 1 year, the mean surgical competency score of the intervention arm participants was 28.6 (71.5%), compared with 11.6 (29.0%) for the control (difference 17.0, 95% CI 14.8 to 19.4, p<0.001).

Conclusion: These results support the pursuit of financial, advocacy and research investments to establish simulation surgery training units and courses including instruction, feedback, deliberate practice and reflection with outcome measurement to enable trainee glaucoma surgeons to engage in intense simulation training for glaucoma surgery.

Trial registration number: PACTR201803002159198.

Nyabongo L, Kanduma EG, Bishop RP, Machuka E, Njeri A, Bimenyimana AV, Nkundwanayo C, Odongo DO, Pelle R. "Prevalence of tick-transmitted pathogens in cattle reveals that Theileria parva, Babesia bigemina and Anaplasma marginale are endemic in Burundi." Parasit Vectors. 2021;14(1):6. Abstract

Tick-borne diseases (TBDs) constitute a major constraint for livestock development in sub-Saharan Africa, with East Coast fever (ECF) being the most devastating TBD of cattle. However, in Burundi, detailed information is lacking on the current prevalence of TBDs and on the associated economic losses from mortality and morbidity in cattle as well as the costs associated with TBD control and treatment. The aim of this study was, therefore, to assess the prevalence and spatial distribution of tick-borne pathogens (TBPs) in cattle across the major agro-ecological zones (AEZs) in Burundi.

Baguiya A, Bonet M, Cecatti JG, Brizuela V, Curteanu A, Minkauskiene M, Jayaratne K, Ribeiro-do-Valle CC, Budianu M-A, Souza JP, Kouanda S. "Perinatal outcomes among births to women with infection during pregnancy." Arch Dis Child. 2021;106(10):946-953. Abstract

This study is part of the Global Maternal Sepsis Study (GLOSS). It aimed to estimate neonatal near-miss (NNM) and perinatal death frequency and maternal risk factors among births to women with infection during pregnancy in low-income and middle-income countries (LMIC).

Baguiya A, Bonet M, Cecatti JG, Brizuela V, Curteanu A, Minkauskiene M, Jayaratne K, Ribeiro-do-Valle CC, Budianu M-A, Souza JP, Kouanda S. "Perinatal outcomes among births to women with infection during pregnancy." Arch Dis Child. 2021;106(10):946-953. Abstract

This study is part of the Global Maternal Sepsis Study (GLOSS). It aimed to estimate neonatal near-miss (NNM) and perinatal death frequency and maternal risk factors among births to women with infection during pregnancy in low-income and middle-income countries (LMIC).

Mitchell EJ, Pallotti P, Qureshi ZP, Daniels JP, Oliver M, Were F, Osoti A, Gwako G, Kimani V, Opira J, Ojha S. "Parents, healthcare professionals and other stakeholders' experiences of caring for babies born too soon in a low-resource setting: a qualitative study of essential newborn care for preterm infants in Kenya." BMJ Open. 2021;11(6):e043802. Abstract

Prematurity is the leading cause of global neonatal and infant mortality. Many babies could survive by the provision of essential newborn care. This qualitative study was conducted in order to understand, from a family and professional perspective, the barriers and facilitators to essential newborn care. The study will inform the development of an early warning score for preterm and low birthweight infants in low and middle income countries (LMICs).

Burton MJ, Ramke J, Marques AP, Bourne RRA, Congdon N, Jones I, Ah Tong BAM, Arunga S, Bachani D, Bascaran C, Bastawrous A, Blanchet K, Braithwaite T, Buchan JC, Cairns J, Cama A, Chagunda M, Chuluunkhuu C, Cooper A, Crofts-Lawrence J, Dean WH, Denniston AK, Ehrlich JR, Emerson PM, Evans JR, Frick KD, Friedman DS, Furtado JM, Gichangi MM, Gichuhi S, Gilbert SS, Gurung R, Habtamu E, Holland P, Jonas JB, Keane PA, Keay L, Khanna RC, Khaw PT, Kuper H, Kyari F, Lansingh VC, Mactaggart I, Mafwiri MM, Mathenge W, McCormick I, Morjaria P, Mowatt L, Muirhead D, Murthy GVS, Mwangi N, Patel DB, Peto T, Qureshi BM, Salomão SR, Sarah V, Shilio BR, Solomon AW, Swenor BK, Taylor HR, Wang N, Webson A, West SK, Wong TY, Wormald R, Yasmin S, Yusufu M, Silva JC, Resnikoff S, Ravilla T, Gilbert CE, Foster A, Faal HB. "The Lancet Global Health Commission on Global Eye Health: vision beyond 2020." Lancet Glob Health. 2021;9(4):e489-e551.Website
Golden L, Chaya S, Reichmuth K, Visagie A, Ayuk A, Kwarteng Owusu S, Marangu D, Affendi N, Lakhan A, Gray D, Vanker A, Zar H, Zampoli M. "Aetiology and presentation of childhood pleural infections in the post-pneumococcal conjugate vaccine era in South Africa." Afr J Thorac Crit Care Med. 2021;27(4). Abstract

Complications of respiratory infections including pleural effusion (PE) are associated with a high morbidity. Differentiating between PE caused by (Mtb) infection and other bacterial infections in endemic areas is difficult in children, thus, impacting treatment.

Sura M, Osoti A, Gachuno O, Musoke R, Kagema F, Gwako G, Ondieki D, Ndavi PM, Ogutu O. "Effect of umbilical cord milking versus delayed cord clamping on preterm neonates in Kenya: A randomized controlled trial." PLoS One. 2021;16(1):e0246109. Abstract

Delayed cord clamping (DCC) is a placental to new-born transfusion strategy recommended by obstetric and gynaecological societies. Though not widely adopted, umbilical cord milking (UCM) may achieve faster transfusion when DCC cannot be performed such as when a neonate requires resuscitation.

Kaoga J, Olago D, Ouma G, Ouma G, Onono J. "The evolving cultural values and their implications on the Maasai Pastoralists, Kajiado County, Kenya.". 2021;13:e00881. AbstractWebsite

The Maasai pastoralists inhabiting Kajiado County have been known for their rich cultural values which have sustained their livelihoods. However, these cultural practices are evolving under the swift development context with the private holding of land becoming more prevalent. Before these disturbances, customary land was available for the Maasai pastoralists to carry out traditional production systems. The disturbance in their social-cultural ways following land fragmentation has rendered their traditional governance system untenable. Moreover, the Maasai pastoralists have been dispossessed from their customary land and social institutions which have shaped their customs. Thus, concerns have been raised over the sustenance of pastoralism considering that the required resources are either unavailable or not enough. To address this gap, there was the need to understand cultural adjustments and their impacts on the Maasai pastoralists’ societal needs. The study employed a cross-sectional design which consisted of 195 Household survey questionnaires, 8 Focus Group Discussions and 18 Key Informant Interviews. The qualitative and quantitative data from the study were summarized and thematic perceptions generated. The results of this study revealed the uniqueness of the Maasai pastoralists’ traditional social structures. Also highlighted by the study was the erosion of the traditional social relations exposing the Maasai pastoralists to increasing vulnerability. These findings support the need for external support to supplement the traditional coping strategies to balance the ecological, social and economic systems of the Maasai pastoralists.

Kimani E, Muhula S, Kiptai T, Orwa J, Odero T, Gachuno O. "Factors influencing TB treatment interruption and treatment outcomes among patients in Kiambu County, 2016-2019." PLoS One. 2021;16(4):e0248820. AbstractWebsite

Tuberculosis (TB) is the leading cause of mortality as a single infectious agent globally with increasing numbers of case notification in developing countries. This study seeks to investigate the clinical and socio-demographic factors of time to TB treatment interruption among Tuberculosis patients in Kiambu County, 2016-2019. We retrospectively analyzed data for all treatment outcomes patients obtained from TB tracing form linked with the Tuberculosis Information Basic Unit (TIBU) of patients in Kiambu County health facilities using time to treatment interruption as the main outcome. Categorical variables were presented using frequency and percentages. Kaplan-Meir curve was used to analyze probabilities of time to treatment interruptions between intensive and continuation phases. Log-rank test statistics was used to compare the equality of the curves. Cox proportion model was used to determine determinants of treatment interruption. A total of 292 participants were included in this study. Males were 68%, with majority (35%) of the participants were aged 24-35 years; 5.8% were aged 0-14 years and 5.1% aged above 55 years. The overall treatment success rate was 66.8% (cured, 34.6%; completed 32.2%), 60.3% were on intensive phase of treatment. Lack of knowledge and relocation were the major reasons of treatment interruptions. Patients on intensive phase were 1.58 times likely to interrupt treatment compared to those on continuation phase (aHR: 1.581; 95%CI: 1.232-2.031). There is need to develop TB interventions that target men and middle aged population in order to reduce treatment interruption and increase the treatment success rates in the County and Country.

Nyabongo L, Odongo DO, Milton G, Machuka E, Vudriko P, Pelle R, Kanduma EG. "Molecular survey of cattle ticks in Burundi: First report on the presence of the invasive Rhipicephalus microplus tick." PLoS One. 2021;16(12):e0261218. Abstract

A recent research study on prevalence of tick-borne pathogens in Burundi reported high prevalence and endemicity of Theileria parva, Anaplasma marginale and Babesia bigemina infections in cattle. Detailed information about tick species infesting animals, their distribution and genetic diversity in Burundi is outdated and limited. This study therefore assessed the prevalence and genetic diversity of tick species infesting cattle across agroecological zones (AEZs) in Burundi. A cross-sectional study on the occurrence of tick species was conducted in 24 districts of Burundi between October and December 2017. Differential identification and characterization of ticks collected was conducted using tick morphological keys and molecular tools (cox1 and 12S rRNA gene). Chi-square test was used to test for association between agroecological zones and the prevalence of tick species. Phylogenetic relationships were inferred using bayesian and maximum likelihood algorithms. A total of 483 ticks were collected from the five AEZs sampled. Six tick species comprising of Rhipicephalus appendiculatus, R. sanguineus, R. evertsi evertsi, R. microplus, R. decoloratus and Amblyomma variegatum were observed. Rhipicephalus appendiculatus were the most prevalent ticks (~45%). A total of 138 specimens (28%) were found to be Rhipicephalus microplus, suggesting an emerging threat for cattle farmers. Twelve R. appendiculatus cox1 haplotypes were obtained from 106 specimens that were sequenced. Two cox1 haplotypes of R. microplus which clustered into previously reported Clade A were observed. Rhipicephalus sanguineus and R. evertsi evertsi ticks, the vectors of numerous zoonotic pathogens, were collected from cattle, which constitute a high risk for public health. These findings reveal an overlapping distribution of tick vectors in Burundi. The design of ticks and tick-borne diseases control strategies should consider the distribution of different vectors across the AEZs particularly the presence of the highly invasive R. microplus tick in Burundi and the potential risk of introducing the pathogenic Babesia bovis.

Peter SG, Kariuki HW, Aboge GO, Gakuya DW, Maingi N, Mulei CM. "Prevalence of Ticks Infesting Dairy Cattle and the Pathogens They Harbour in Smallholder Farms in Peri-Urban Areas of Nairobi, Kenya." Veterinary Medicine International. 2021;2021:9501648. AbstractWebsite

This study aimed at determining the tick species infesting dairy cattle in Nairobi, Kenya, and the pathogens they harbour. While ticks are well-known vectors of major bacterial pathogens of both veterinary importance and public health importance, few studies have investigated the range of the tick species and the associated pathogens, especially present in unique dairy production systems, which compromise animal welfare, such as those in peri-urban areas. A cross-sectional study was undertaken involving 314 randomly selected dairy cattle in 109 smallholder farms. Each animal was examined for attached ticks followed by morphological tick identification at the species level. Genomic DNA was extracted from each of the ticks, and 16S rDNA gene was amplified for pathogen identification. Sequencing of the amplicons and subsequent BLASTn analysis, multiple sequence alignment, and phylogenetic reconstruction were performed to confirm the species of the pathogens. Sixty-six (21.0%) of the cattle examined had ticks. A total of 94 adult ticks were found on the cattle, and of these, 63 (67.0%), 18 (19.1%), and 13 (13.8%) were in the genera Rhipicephalus, Amblyomma, and Hyalomma, respectively. Twelve tick species in Rhipicephalus genus and two in Amblyomma and Hyalomma genera were identified. Although Rh. decoloratus was the most prevalent tick (24.5% (23/94)), the emerging Rh. microplus (6.4% (6/94)) was also identified. The DNA of Rickettsia was detected in the ticks, with Rickettsia conorii in H. rufipes and A. variegatum, and Rickettsia aeschlimannii in Rh. microplus and H. rufipes, while Ehrlichia ruminantium and E. canis were in A. variegatum. In conclusion, the study reported a wide range of tick species present in the study area including Rhipicephalus microplus, which is an emerging tick species in parts of Kenya. The ticks harboured DNA of Rickettsia and Ehrlichia, highlighting possible animal and human health concerns. Hence, effective tick control strategies remain paramount to prevent potential diseases associated with the harboured pathogens.

MM B, M B, J F, EA L, A A, K A, GA B, WD B, E B, C C, H D, P D'A, L DC, N F, A M. "Diagnostic performance of a colorimetric RT -LAMP for the identification of SARS-CoV-2: A multicenter prospective clinical evaluation in sub-Saharan Africa." EClinicalMedicine. 2021. Abstract
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Kamunya SM, Oboko RO, Maina EM, Miriti EK. " A Systematic Review of Gamification Within E-Learning." igi-global.com. 2021:18. AbstractWebsite

The focus of this study was to review and evaluate the effectiveness of gamification within e-learning platforms. The study deployed systematic literature review methodology to evaluate how effective gamification has been used within e-learning platforms. The study used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Approach (PRISMA), starting with 366 articles, shifting to a final 34 articles for consideration. It was established that gamification positively influences and enhances learning within the e-learning platform. Therefore, the study recommends policy makers, designers, and implementers of e-learning platforms to consider incorporating gamification elements in order to increase user motivation and engagement for enhanced learning.

Mugo, N, Nancy N. Karanja, Gachene CN, Klaus Dittert, Harun I. Gitari, E. S-G. " Response of potato crop to selected nutrients in central and eastern highlands of Kenya. ." Cogent Food & Agriculture. . 2021;7(1):1898762..
Kalele DN, Ogara WO, Oludhe C, Onono JO. ", Climate change impacts and relevance of smallholder farmers’ response in arid and semi-arid lands in Kenya." Scientific African. 2021;12:https://doi.org/10.1016/j.sciaf.2021.e00814.
Ireri C, KRHODA GO, Mukhovi MS. "2. Social-Economic Threshold Factors for Gully Erosion Stabilization in Semi-Arid Environment of Wanjoga River Catchment, Upper Tana Basin, Kenya." International Journal of Agriculture, Environment and Bioresearch. 2021;6(5):172-187.
Wangusi BMUYUKANI, Kanja LW, Ole-Mapenay IM, Onyancha JM. "Acute Toxicity, Phytochemical Screening, Analgesic, and Anti-Inflammatory Activities of Aqueous and Methanol Root Extracts of Maerua triphylla A. Rich. (Capparaceae)." Evidence-Based Complementary and Alternative Medicine. 2021;Volume 2021, Article ID 3121785, :9 pages.
Wangusi BMUYUKANI, Kanja LW, Ole-Mapenay IM, Onyancha JM. "Acute Toxicity, Phytochemical Screening, Analgesic, and Anti-Inflammatory Activities of Aqueous and Methanol Root Extracts of Maerua triphylla A. Rich. (Capparaceae)." Evidence-Based Complementary and Alternative Medicin. 2021;2021:11.
Babiaka SB, Simoben CV, Abuga KO, Mbah JA, Karpoormath R, Ongarora D, Mugo H, Monya E, Cho-Ngwa F, Sippl W, Loveridge JE, Ntie-Kang F. "Alkaloids with Anti-Onchocercal Activity from Voacanga africana Stapf (Apocynaceae): Identification and Molecular Modeling." Molecules. 2021;26(1):70. Abstract

A new iboga-vobasine-type isomeric bisindole alkaloid named voacamine A (1), along with eight known compounds—voacangine (2), voacristine (3), coronaridine (4), tabernanthine (5), ibox-ygaine (6), voacamine (7), voacorine (8) and conoduramine (9)—were isolated from the stem bark of Voacanga africana. The structures of the compounds were determined by comprehensive spec-troscopic analyses. Compounds 1, 2, 3, 4, 6, 7 and 8 were found to inhibit the motility of both the microfilariae (Mf) and adult male worms of Onchocerca ochengi, in a dose-dependent manner, but were only moderately active on the adult female worms upon biochemical assessment at 30 μM drug concentrations. The IC50 values of the isolates are 2.49–5.49 µM for microfilariae and 3.45–17.87 µM for adult males. Homology modeling was used to generate a 3D model of the O. ochengi thioredoxin reductase target and docking simulation, followed by molecular dynamics and binding free energy calculations attempted to offer an explanation of the anti-onchocercal struc-ture–activity relationship (SAR) of the isolated compounds. These alkaloids are new potential leads for the development of antifilarial drugs. The results of this study validate the traditional use of V. africana in the treatment of human onchocerciasis.

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