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Forthcoming
Kahiga RM, Gatumu JC, Nteere JS. "Sustainability of the implementation of the Preschool physical education curriculum in Nairobi and Nyeri counties.". In: Africa for Research in Comparative Education Society. Kenya Science Campus; Forthcoming.
Gichuki N. Banking Law: Cases and Materials.; Forthcoming.
Geyer. S and Wairire GG, Lombard A, Wairire GG. "A comparative content analysis of South African and Kenyan drug policies from a social development perspective." The Social Work Practitioner-Researcher. Forthcoming.
and Goodluck Charles, Søren Jeppesen PKPK. "Firm-Level Perspectives on State-Business Relations in Africa: The Food processing Sector in Kenya, Tanzania and Zambia." Forum for Development Studies Journal. Forthcoming.
Gona, George, Wambui Kiai, Muiru Ngugi (Eds.). Women in Public Space(s) in Kenya. University of Nairobi & Ford Foundation; Forthcoming.
Submitted
Olsvik O, Mitema ES, Gathuma J, Mirza N. "Acquired tetracycline resistance genes in nosocomial Salmonella typhimurium infection in a Kenyan hospital.". Submitted. AbstractWebsite

Tetracyclines have been among the most widely used antibiotics worldwide. Plasmid-mediated tetracycline resistance among hospital strains of bacteria has continued to rise and of major concern has been the transfer of resistance to pathogenic organisms. Bacteraemia due to hospital acquired S. typhimurium has been a major cause of morbidity at Kenyatta National Hospital (KNH), hence the need to study drug susceptibility pattern of this organism. This study also characterized the tetracycline resistance genes using oligonucleotide probes. Ninety seven S. typhimurium strains isolated from patients at KNH were used. Agar dilution method was used to determine minimum inhibitory concentration (MIC). Plasmids were isolated from each strain and the different plasmid profiles were grouped by their molecular weights into 6 patterns. Out of 97, 87 (88%) strains were resistant. MIC ranged from 1 microgram/ml to 128 micrograms/ml. Genes encoding for tetracycline resistance were located on plasmids of molecular weights 65 MDa, 5.2 or both. Plasmid-encoded antimicrobial resistance is likely to spread to other pathogenic organisms, reduce our ability to treat the infection and increase the cost and duration of treatment.

Jani PG, Gill H, Kotecha V. "Difficult Gallbladder Surgery, Improving Patient Outcomes Through Appropriate Surgical Decisions." East and Central African Journal of Surgery. Submitted;17(1).
Githaiga JW. Evaluation of diagnostic peritoneal lavage and needle paracentesis in the management of penetrating and blunt abdominal trauma, at Kenyatta National Hospital.; Submitted. Abstract

OBJECTIVE: To determine the accuracy and sensitivity of diagnostic peritoneal lavage in the assessment of intra-abdominal injury using the dipstick method. DESIGN: Prospective study, involving the performance of diagnostic peritoneal lavage in the out patient department and surgical wards prior to surgical intervention. SETTING: Kenyatta National Hospital-General Surgical and Orthopaedic wards and outpatient department. The study was conducted over a duration of six months, starting from January 1995 to July 1995. RESULTS: Ninety six patients with penetrating (68) and blunt (28) abdominal trauma underwent diagnostic peritoneal lavage as evaluation of the severity of abdominal trauma. Dipstick (combur 9 strips) was used to evaluate lavage effluent for red blood cells, white blood cells, protein and bilirubin. Forty three patients had positive diagnostic peritoneal lavage (DPL) results, of which 40 (93%) had positive findings at laparatomy and three (7%) had negative findings at laparatomy. The remaining 53 patients had negative DPL results and were managed conservatively. One patient with a negative DPL result became symptomatic and had a positive laparatomy. Conservatively managed patients were discharged after 24 hours observations without any complications. DPL had an accuracy and sensitivity of 93% and specificity of 98%. CONCLUSION: Diagnostic peritoneal lavage is a cheap, safe and reliable method for assessment of abdominal trauma. The method is easy to perform by trained junior doctors in the OPD, or as a bedside procedure. Use of this method reduced negative laparotomy rate from 50% to 6.9% and average duration of stay from 6.5 days to 1.9 days. This method is recommended as a basic tool in the assessment of abdominal trauma patients

Gathigi GW. "FM Radio Broadcasting in Local Languages Triggering Rural Empowerment in Kenya." Jahazi Arts and Culture Journal. Submitted.
Mungai NN, Kibwage IO, Mwangi JW, Guantai AN, Njogu PM, Ongarora DSB. "Isolation, Characterization and Antiplasmodial Activity of Phytochemical Constituents from Monanthotaxis parvifolia (Oliv.) Verdc ssp. kenyensis Verdc." East and Central African Journal of Pharmaceutical Sciences. Submitted;17:87-93.abstract__mungai_et_al._2014.pdf
Weinstein, A. EORTALWAGMCSS, Ebinger, C. ORTALWAGMSSC, Oliva, S. RTALWAGMSCM, Roecker, S. TALWAGMCMC, Tiberi, C. ALWAGMMCE, Aman, M. LWAGMCEJ, Lambert, C. WAGMEJS, Witkin, E. AGMJS, Albaric, J. GMS, Gautier, S. M, Muzuka, A. MKHI-KMFPMRGGR, Mulibo, G. KG, Kianji, G., Hadfield, R. I-KMFPMRFMR, Illsley-Kemp, F. MFPMRMRS, Msabi, M. FPMRRSJ, Ferdinand, R. PMRSJ, Peyrat, S. MRJ, Muirhead, J. R, Rodzianko, A., Fischer T. "Magmatic Co2 assisted rifitng in East Africa : seismicity of the Magadi-Natron-Manyara basins, Africa. Submitted to Tectonics." tectonics. Submitted.
Parton WJ, Scurlock JMO, Ojima DS, Gilmanov TG, Scholes RJ, Schimel DS, Kinyamario JI. "Observations and modeling of biomass and soil organic matter dynamics for the grassland biome worldwide.". Submitted. AbstractObservations and modeling of biomass and soil organic matter dynamics for the grassland biome worldwide

Century is a model of terrestrial biogeochemistry based on relationships between climate, human management (fire, grazing), soil properties, plant productivity, and decomposition. The grassland version of the Century model was tested using observed data from 11 temperate and tropical grasslands around the world. The results show that soil C and N levels can be simulated to within ±25% of the observed values (100 and 75% of the time, respectively) for a diverse set of soils. Peak live biomass and plant production can be simulated within ± 25% of the observed values (57 and 60% of the time, respectively) for burned, fertilized, and irrigated grassland sites where precipitation ranged from 22 to over 150 cm. Live biomass can be generally predicted to within ±50% of the observed values (57% of the time). The model underestimated the live biomass in extremely high plant production years at two of the Russian sites. A comparison of Century model results with statistical models showed that the Century model had slightly higher r2 values than the statistical models. Data and calibrated model results from this study are useful for analysis and description of grassland carbon dynamics, and as a reference point for testing more physiologically based models prediction's of net primary production and biomass. Results indicate that prediction of plant and soil organic matter (C and N) dynamics requires knowledge of climate, soil texture, and N inputs.

Mutinda, Nyaga PN, Mbuthia PG, Bebora LC, G.Muchemi. "Risk factors associated with infectious bursal disease vaccination failures in broiler farms in Kenya. ." Trop Anim Health Prod.. Submitted.
Muia JMK, Kariuki JN, Mbugua PN, Gachuiri CK, Lukibisi LB, Ayako WO, Ngunjiri WV. "Smallholder dairy production in high altitude Nyandarua milk-shed in Kenya: Status, challenges and opportunities.". Submitted. AbstractWebsite

A stratified sampling method was used to select 156 dairying households from representative Divisions in Nyandarua County. The stratification was based on cattle grazing systems (CGS) and agro-ecological zones (AEZs) across the Divisions. The objectives of the study were to assess status of smallholder dairy cattle production in relationship to CGS and AEZ, major challenges facing smallholder dairy production, and the opportunities for improvement. Data collected included the characteristics of the farm, family, farmer, feeds and feeding, dairy cattle and their performance, milk uses and markets, and the dairy production services. The information on the challenges facing dairy production and the opportunities for improvement was obtained from discussions with livestock extension workers, dairy co-operatives, milk processors, and from secondary sources. The present results indicated that the average farm size was 3.5 Ha and 41, 38, and 44% of the households fed dairy stock with improved fodders, grass hay, and concentrate supplements, respectively. Among the households, about 44, 38 and 32% had access to artificial insemination (AI), extension, and all weather roads services, respectively. Households keeping crosses of the dairy breeds were 59% while the average herd size was 5.3 heads consisting of 40% cows in milk. The average calf live-weight gain was 322g/ day and milk yield per cow was 8.4kg/day. About 65% of the milk was marketed at an average price of 15.00 KES/kg, equivalent to 0.205 US$/kg. As the levels of dairy intensification increased, there were significant increase in milk production per hectare and decrease in calf live-weight gains (P<0.05). On the other hand, as the level of agricultural potential increased, there were significant decreases in milk production and marketed milk per farm (P<0.05). It was concluded that smallholder dairy cattle production was below the potential for Nyandarua County and was influenced by the CGS and AEZs. The major challenges in smallholder dairy production included poor road network and milk marketing, high costs and inaccessibility of dairy production inputs and support services, inappropriate dairy production technologies, and limited value addition of milk.

Gitao CG, Bebora L. "Subclinical mastitis affecting hygienic quality of marketed camel milk from North - Eastern Province, Kenya.". Submitted. Abstractsubclinical_mastitis_affecting_hygienic_quality_of.pdfWebsite

North Eastern Province, camel is the dominant livestock; it provides subsistence to many people especially during the frequent droughts when other animals either die or are unthrifty. This is beca use camel is highly suited for hot environments. In this region, camels number approximately 3 million and are the main producers of milk for the residents, who are mainly of Somali origin, and are pastoralists. Currentl y, the milk is also sold in Nairobi and other far places; and there is a fast growing demand for it. This has necessitated examination of the milk quality, in response to food safety awareness, especially noting that some of the bacteria causing subclinical mastitis can cause disease in humans. This study was carried out to establish the hygienic quality of camel milk from this area, zeroing down to 2 districts, Garissa and Wajir. T hree hundred and eighty four bulk camel milk samples were collected in volumes of 200 to 300 ml. They wer e transport ed to the laboratory in cold/ice boxes and bacterial isolation and characterization done not later than 24 h after arrival at the laboratory. Before culturing, the milk samples were screened using Ca lifornia Mastitis Test (CMT); samples testing positive (a n indication of subclinical mastitis) were then subjected to bacteriological investigation, using standard methods. Results of this study have shown that subclin ical mastitis is prevalent in dromedary camels of Garissa and Wajir districts of North Eastern province of Kenya, and that Gram positive cocci ( Staphylococcus and Streptococcus) are the dominant mastitis pathogens isolated. Other isolated bacteria included Klebsiella/Enterobacter, E scherichia coli and Bacillus. The positive correlation of CMT with the presen ce of mastitis pathogens in camel milk showed that CMT is a useful screening test in the detection of subclinical mastitis in camels; it is thus a useful tool for farm ers, aiding them in picking the affected animals, segregating and treating them. The resu lts also contribute towards coming up with respective control measures so as to keep camel milk fresh for longer periods and als o make it safe for human consumption.

Okeng'o GO, Malo JO, Awuor JB, Genga RO. "Testing Structure Formation in the Universe via Coupled Matter Fluids.". Submitted.
Gripenberg U, Saarinen I, Bwibo NO, Oduori ML, Grayburn JA, Awori NW, Wasunna AE, Kinuthia DM. "Two true hermaphrodites with XX chromosomes.". Submitted.
Githigia SM, Njagi LW, Mbuthia PG, Gathumbi PK, Cooper ME, Cooper JE. "veterinary forensic medicine: an emerging and important discipline.". Submitted.Website
Adwok JA, Githaiga JW. "Wandering spleen presenting as a right hypochondrial mass and intestinal obstruction.". Submitted. Abstract

This is a case report of a 23 year old multiparous woman who presented with intestinal obstruction and a right hypochondrial mass. Laparatomy revealed an infarcted 1.4 Kg spleen in the right lumbar region compressing the ascending colon. There was also ileal volvulus around the splenic pedicle. This is probably the first documented case of wandering spleen in the right hypochondrium, presenting as right large bowel obstruction, to be reported in our region. Wandering spleen is a rare condition, often asymptomatic, but may present as an acute abdomen. Pre-operative diagnosis is difficult and rarely made. Laboratory tests are seldom useful, but imaging studies do assist. Up to 1971 only 350 cases had been reported in the western literature. Review of English literature from 1900 to 1991 reported only 51 cases in children. In our region 11 cases were reported in Uganda between 1968 and 1971. No other literature is available from our region. Clinical presentation, aetiology, investigation, and management of wandering spleen is discussed

Githaiga JW, Adwok JA. "Wandering spleen presenting as a right hypochondrial mass and intestinal obstruction.". Submitted. Abstract

This is a case report of a 23 year old multiparous woman who presented with intestinal obstruction and a right hypochondrial mass. Laparatomy revealed an infarcted 1.4 Kg spleen in the right lumbar region compressing the ascending colon. There was also ileal volvulus around the splenic pedicle. This is probably the first documented case of wandering spleen in the right hypochondrium, presenting as right large bowel obstruction, to be reported in our region. Wandering spleen is a rare condition, often asymptomatic, but may present as an acute abdomen. Pre-operative diagnosis is difficult and rarely made. Laboratory tests are seldom useful, but imaging studies do assist. Up to 1971 only 350 cases had been reported in the western literature. Review of English literature from 1900 to 1991 reported only 51 cases in children. In our region 11 cases were reported in Uganda between 1968 and 1971. No other literature is available from our region. Clinical presentation, aetiology, investigation, and management of wandering spleen is discussed

Seth D. Goldstein, MD1; Dominic Papandria MD2; ALMDMPH3;, ani Georges Azzies, MD4; Eric Borgstein FRCS5; CMD6; SFMDMPH7; PJMBCB;RG, Mary Klingensmith, MD9; Mohamed Labib10 FLMD; MMMD11; EO’F12; RRMDMPH7;A, Fizan Abdullah, MD PD1. “Innovative approaches to educating the global surgical worldforce: A pilot camparison of online curricula for use in low and middle income countries”.; Submitted.
Muchane M, Githiru M. "The birds of Gongoni Forest Reserve South Coast, Kenya." SCOPUS. Submitted:1. Abstract
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Mwangi E, Gatari M. "Curriculum Development of a Nuclear Engineering Course for Human Resources Enhancement in the Kenya Nuclear Energy Program." kns.org. Submitted. AbstractWebsite

In order to increase generation capacity from reliable sources, Kenya has proposed to install a low-end nuclear power plant to supplement the envisaged short fall. At the moment, most of the power is generated from hydro and geothermal sources. Although an expansion of …

NYAMBANE MN, GATARI MJ, Githiri JG,... "Energy and Exergy Analysis Concepts: Modelling of Olkaria II Geothermal Power Plant in Kenya." promitheasnet.kepa.uoa.gr. Submitted. AbstractWebsite

Condensers of geothermal power plants need to operate at low pressures to ensure optimal use of energy resources. To optimize the steam condensation process cooling water temperature is varied to determine the value that gives a higher condenser efficiency …

Maina DM, Gatari MM, Bartilol SK, Nguli MK. "ESSENTIAL TRACE METALS IN SELECTED MAIZE FLOUR BRANDS CONSUMED IN NAIROBI, KENYA: APPLICATION OF TXRF." imeko.org. Submitted. AbstractWebsite

Human beings obtain their essential trace metals form their diets. The objective of this study was to determine the Mn, Fe, Cu, and Zn concentration levels in maize flour and based on the results estimate the daily intake of these essential metals through consumption of Ugali; …

Kairu WM, Gatari MM, MUIA ML, Mumenya SW,... "Health monitoring of concrete using rebar-guided ultrasound." pdfs.semanticscholar.org. Submitted. AbstractWebsite

Concrete is one of the commonly used materials worldwide in the construction industry due to its durability [1]. Civil infrastructures such as power plants, bridges and large buildings are typically built using concrete. It is typically composed of aggregate, sand, cement, water as …

G. PROFSIMIYUVINCENT. "Human Settlement in South Nyanza.". In: Procedings of a Conference sponsored by the Swedish agency for Research co-operation with Development Countries (SAREC) and organised by the Centre for Archaelogy and Antiquties, University of Tananarive Madagascar, SAREC, Sweden.; Submitted. Abstract

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BIRIR JK, GATARI MJ, RAJAGOPAL P, MUIA ML. "Improved Resolution in Guided Wave Testing." pdfs.semanticscholar.org. Submitted. AbstractWebsite

Guided wave technology is today widely used for long range ultrasonic testing, especially for pipeline, tank floor and rail track condition monitoring. In pipeline inspection for instance guided wave testing (GWT) offers advantages over other mainstream technologies such as …

G PROFGATEIDAVID. "J E Sanderson, E G Olsen, and D Gatei.Peripartum heart disease: an endomyocardial biopsy study.". In: Br Heart J. 56(3): 285. RIVERBRROKS COMMUNICATIONS; Submitted. Abstract
Endomyocardial biopsies were performed in 11 African women in Nairobi who presented with the clinical features of peripartum cardiomyopathy. The samples were studied by light and electron microscopy. In five patients there was evidence of a "healing myocarditis", that is the presence of a mild inflammatory cell infiltration within the myocardium with foci of necrosis and variable amounts of hypertrophy and fibrosis. Of the nine patients who were followed up, three out of four with myocarditis had persistent heart failure and four out of five without myocarditis improved. Peripheral blood T lymphocyte cell subsets were measured in nine patients by means of monoclonal antibodies. A high helper:suppressor T cell ratio was found in three patients. Almost half of this group of patients with peripartum cardiomyopathy had myocarditis in their biopsy specimens. The myocarditis may have been due to an inappropriate immunological reaction in some patients.
G. PROFSIMIYUVINCENT. "Les Classes Sociales en Afrique de Iquest Pre-Coloniale in He-CHI Revue dEtudes Francaises de Iuniversite de Nairobi.". In: P. 47-53 Editorship: African in Time Perspective. Weekly Radio Talks on African History, V.O.K.; Submitted. Abstract

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G PROFKARANJAJOSEPH, OTIENO DRODAWAFRANCISXAVIER. "NJOROGE W, NDAVI PM, KARANJA JG, MATI JKG. The incidence of cervical extropion among women on contraceptive methods in two periurban areas in Nairobi. J. Obst. Gynaec. East Cent. Afr. 15:00-00.". In: J. Obst. Gynaec. East Cent. Afr. 15:00-00. EM Ngatia, LW Gathece, FG Macigo, TK Mulli, LN Mutara, EG Wagaiyu.; Submitted. Abstract
PIP: This research report studies several biochemical and histochemical aspects of cervical carcinoma and explores their use in follow-up of patients undergoing radiotherapy. Material came from 19 patients with invasive cervical carcinoma admitted to Kenyatta National Hospital. A control group consisted of 20 women matched for age who attended clinics at the hospital but were not suffering from any malignant disease; control tissue for histological examination was obtained from 3 women who had undergone hysterectomy for uterine fibroids. Biochemical assays for alkaline and acid phosphatases in patients with cervical carcinoma show an increase in alkaline phosphatase in carcinomatous tissue (35.7 umoles/hr/mg) as opposed to normal tissue (7.2). Acid phosphatase values were only moderately raised. Assays of the same enzymes in blood showed a less marked difference between patients and controls (ranges of 7.5-20.8 and 3-14, respectively). When examined histochemically, increased alkaline phosphatase activity was observed in connective tissue, epithelium of the glands and blood capillaries of tumor tissue. 1 section containing normal tissue bordering carcinomatous tissue demonstrated normal alkaline phosphatase activity in the normal tissue and increased activity in the tumor tissue. In summary, there is increased enzyme activity around the tumor areas, but values for serum levels show an overlap of normal and abnormal cases and are therefore not predictive. Results demonstrate a clear difference in activities of these enzymes in carcinomatous tissue and normal tissue, which may be of value in follow-up care.
MWANIA MJM, GATARI MJ, MAINA MDM, KINYUA R. "Recycled waste plastics composite: Possible construction material for wind turbine blades." promitheasnet.kepa.uoa.gr. Submitted. AbstractWebsite

Electrical power supply in Sub Saharan Africa (SSA) is expensive and very low, and most families have no chance of accessing clean lighting and cooking power. Off grid systems are the best viable solution in SSA and wind energy has a potential. However, the components …

ASIAGO DORCAH, GATHII ALICE, Ngesu LM, Gunga SO, Gakuru A, Kahigi C, Nyaga VK, Oundo MB, Kamoyo JM, ADEGBORO JS, others. "TEACHERS’PERCEPTIONS OF PERFORMANCE APPRAISAL PRACTICES IN PUBLIC SECONDARY SCHOOLS IN LIMURU DISTRICT.". Submitted. Abstract
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In Press
2020
Naidoo K, Kempen JH, Gichuhi S, Braithwaite T, Casson RJ, Cicinelli MV, Das A, Flaxman SR, Jonas JB, Keeffe JE, Leasher J, Limburg H, Pesudovs K, Resnikoff S, Silvester AJ, Tahhan N, Taylor HR, Wong TY, Bourne RRA. "Prevalence and causes of vision loss in sub-Saharan Africa in 2015: magnitude, temporal trends and projections." Br J Ophthalmol. 2020. AbstractWebsite

Background: This study aimed to assess the prevalence and causes of vision loss in sub-Saharan Africa (SSA) in 2015, compared with prior years, and to estimate expected values for 2020.

Methods: A systematic review and meta-analysis assessed the prevalence of blindness (presenting distance visual acuity <3/60 in the better eye), moderate and severe vision impairment (MSVI; presenting distance visual acuity <6/18 but ≥3/60) and mild vision impairment (MVI; presenting distance visual acuity <6/12 and ≥6/18), and also near vision impairment (

Ong Beng Seng M, Meyer D, Gichuhi S, Tong L, Sudharshan S, Biswas J, Testi I, Agrawal R. "Ocular Surface Disorders in Patients with Human Immunodeficiency Virus (HIV) Infection." Ocul. Immunol. Inflamm.. 2020;5:1-7. AbstractWebsite

To describe ocular surface disorders associated with human immunodeficiency virus (HIV). : Narrative review. : Ocular surface neoplastic conditions, such as Kaposi's sarcoma, conjunctival lymphoma and ocular squamous cell carcinoma along with blepharitis, dry eye disease, and vernal keratoconjunctivitis, constitute ocular surface complications in HIV-infected individuals. : This review will provide a summary of clinical presentations and treatment options for the most common HIV-related ocular surface diseases, indicating the need for a comprehensive ocular examination including ocular surface in all HIV patients.

Yoshizaki M, Ramke J, Furtado JM, Burn H, Gichuhi S, Gordon I, Aghaji A, Marques AP, Dean WH, Congdon N, Buchan J, Burton MJ. "Interventions to improve the quality of cataract services: protocol for a global scoping review." BMJ Open. 2020;10(8):e036413. AbstractWebsite

Cataract is the leading cause of blindness globally and a major cause of vision impairment. Cataract surgery is an efficacious intervention that usually restores vision. Although it is one of the most commonly conducted surgical interventions worldwide, good quality services (from being detected with operable cataract to undergoing surgery and receiving postoperative care) are not universally accessible. Poor quality understandably reduces the willingness of people with operable cataract to undergo surgery. Therefore, it is critical to improve the quality of care to subsequently reduce vision loss from cataract. This scoping review aims to summarise the nature and extent of the published literature on interventions to improve the quality of services for primary age-related cataract globally.

Arunga S, Kintoki GM, Mwesigye J, Ayebazibwe B, Onyango J, Bazira J, Newton R, Gichuhi S, Leck A, Macleod D, Hu VH, Burton MJ. "Epidemiology of Microbial Keratitis in Uganda: A Cohort Study." Ophthalmic Epidemiol. 2020;27(2):121-131. AbstractWebsite

: To describe the epidemiology of Microbial Keratitis (MK) in Uganda.: We prospectively recruited patients presenting with MK at two main eye units in Southern Uganda between December 2016 and March 2018. We collected information on clinical history and presentation, microbiology and 3-month outcomes. Poor vision was defined as vision < 6/60).: 313 individuals were enrolled. Median age was 47 years (range 18-96) and 174 (56%) were male. Median presentation time was 17 days from onset (IQR 8-32). Trauma was reported by 29% and use of Traditional Eye Medicine by 60%. Majority presented with severe infections (median infiltrate size 5.2 mm); 47% were blind in the affected eye (vision < 3/60). Microbiology was available from 270 cases: 62% were fungal, 7% mixed (bacterial and fungal), 7% bacterial and 24% no organism detected. At 3 months, 30% of the participants were blind in the affected eye, while 9% had lost their eye from the infection. Delayed presentation (overall = .007) and prior use of Traditional Eye Medicine (aOR 1.58 [95% CI 1.04-2.42], = .033) were responsible for poor presentation. Predictors of poor vision at 3 months were: baseline vision (aOR 2.98 [95%CI 2.12-4.19], < .0001), infiltrate size (aOR 1.19 [95%CI 1.03-1.36], < .020) and perforation at presentation (aOR 9.93 [95% CI 3.70-26.6], < .0001).: The most important outcome predictor was the state of the eye at presentation, facilitated by prior use of Traditional Eye Medicine and delayed presentation. In order to improve outcomes, we need effective early interventions.

Mwangi N, Bascaran C, Ng'ang'a M, Ramke J, Kipturgo M, Gichuhi S, Kim M, Macleod D, Moorman C, Muraguri D, Gakuo E, Muthami L, Foster A. "Feasibility of a cluster randomized controlled trial on the effectiveness of peer-led health education interventions to increase uptake of retinal examination for diabetic retinopathy in Kirinyaga, Kenya: a pilot trial." Pilot Feasibility Stud. 2020;6:102. AbstractWebsite

Background: People living with diabetes can reduce their risk of vision loss from diabetic retinopathy by attending screening, which enables early detection and timely treatment. The aim of this pilot trial was to assess the feasibility of a full-scale cluster randomized controlled trial of an intervention to increase uptake of retinal examination in this population, as delivered within existing community-based diabetes support groups (DSGs).

Methods: All 16 DSGs in Kirinyaga county were invited to participate in the study. The first two groups recruited took part in the pilot trial. DSG members who met the eligibility criteria were recruited before the groups that were randomized to the two arms. In the intervention group, two peer educators were trained to deliver monthly DSG-based eye health education and individual telephone reminders to attend screening. The control group continued with usual DSG practice which is monthly meetings without eye health education. The recruitment team and outcome assessors were masked to the allocation. We documented the study processes to ascertain the feasibility, acceptability, and potential effectiveness of the intervention. Feasibility was assessed in terms of clarity of study procedures, recruitment and retention rates, level of acceptability, and rates of uptake of eye examination. We set the target feasibility criteria for continuation to the main study to be recruitment of 50 participants in the trial, 80% monthly follow-up rates for individuals, and no attrition of clusters.

Results: Of the 122 DSG members who were assessed for eligibility, 104 were recruited and followed up: 51 (intervention) and 53 (control) arm. The study procedures were well understood and easy to apply. We learnt the DSG meeting days were the best opportunities for recruitment. The study had a high acceptance rate (100% for clusters, 95% for participants) and high follow-up and retention rate (100% of those recruited). All clusters and participants were analysed. We observed that the rate of incidence of eye exam was about 6 times higher in the intervention arm as compared to the control arm. No adverse unexpected events were reported in either arm.

Conclusions: The study is feasible and acceptable in the study population. The results support the development of a full-scale cluster RCT, as the success criteria for the pilot were met.

Gichuhi S, Arunga S. "HIV and the eye." Community Eye Health. 2020;33(108):76-78. AbstractWebsite

This article summarizes the presentation of ocular HIV in East Africa.
The main ocular effects of HIV are related to immune-suppression and impaired tumour-surveillance. HIV compromises cell-mediated immunity increasing the risk of infection with bacteria (e.g. tuberculosis and syphilis); fungi (e.g. candida and cryptococcus); parasites (e.g. toxoplasmosis); and viruses (e.g. herpes zoster, human papilloma virus, Kaposi sarcoma-associated herpes virus, cytomegalovirus and Epstein-Barr virus).
Patients with lower CD4 counts are more likely to have ocular manifestations1, however use of antiretroviral therapy (ART) has modified the epidemiology of ocular manifestations, and variations in the predominant subtype of HIV may also lead to geographical differences in ocular disease.

Mwangi N, Bascaran C, Ramke J, Kipturgo M, Kim M, Ng'ang'a M, Gichuhi S, Mutie D, Moorman C, Muthami L, Foster A. "Peer-support to increase uptake of screening for diabetic retinopathy: process evaluation of the DURE cluster randomized trial." Trop Med Health. 2020;48:1. AbstractWebsite

Background: There is limited evidence on how implementation of peer support interventions influences effectiveness, particularly for individuals with diabetes. We conducted a cluster randomized controlled trial to compare the effectiveness of a peer-led health education package versus usual care to increase uptake of screening for diabetic retinopathy (DR).

Methods: Our process evaluation used a mixed-method design to investigate the recruitment and retention, reach, dose, fidelity, acceptability, and context of implementation, and was guided by the Consolidated Framework for Implementation Research (CFIR). We reviewed trial documents, conducted semi-structured interviews with key informants (n = 10) and conducted four focus group discussions with participants in both arms of the trial. Three analysts undertook CFIR theory-driven content analysis of the qualitative data. Quantitative data was analyzed to provide descriptive statistics relevant to the objectives of the process evaluation.

Results: The trial had positive implementation outcomes, 100% retention of clusters and 96% retention for participants, 83% adherence to delivery of content of group talks (fidelity), and 78% attendance (reach) to at least 50% (3/6) of the group talks (dose). The data revealed that intervention characteristics, outer setting, inner setting, individual characteristics, and process (all the constructs of CFIR) influenced the implementation. There were more facilitators than barriers to the implementation. Facilitators included the relative advantage of the intervention compared with current practice (intervention characteristics); awareness of the growing prioritization of diabetes in the national health policy framework (outer setting); tension for change due to the realization of the vulnerability to vision loss from DR (inner setting); a strong collective sense of accountability of peer supporters to implement the intervention (individual characteristics); and regular feedback on the progress with implementation (process). Potential barriers included the need to queue at the eye clinic (intervention characteristic), travel inconveniences (inner setting), and socio-political disruption (outer setting).

Conclusions: The intervention was implemented with high retention, reach, fidelity, and dose. The CFIR provided a valuable framework for evaluating contextual factors that influenced implementation and helped to understand what adaptations may be needed during scale up.

Gitao, C.G. Reviewer, Transboundary and Emerging diseases. Trsansboundary and Emerging Diseases; 2020.tbed_reviewer_certificate_1_1.pdf
Muia BM, Mbaria JM, Kanja LW, Gitahi N, Okumu PO, Okumu MO. "Acute and sub-acute toxicity study of the root extracts of Fagaropsis hildebrandtii in mice and evaluation of their antimicrobial effects." F1000Research,. 2020;8(1444).
Opanda S, Bulimo W, Gachara G, Ekuttan C, Amukoye E. "Assessing antigenic drift and phylogeny of influenza A (H1N1) pdm09 virus in Kenya using HA1 sub-unit of the hemagglutinin gene." PLoS One. 2020;15(2):e0228029. Abstractpone.0228029.pdf

Influenza A (H1N1) pdm09 virus emerged in North America in 2009 and has been established as a seasonal strain in humans. After an antigenic stasis of about six years, new antigenically distinct variants of the virus emerged globally in 2016 necessitating a change in the vaccine formulation for the first time in 2017. Herein, we analyzed thirty-eight HA sequences of influenza A (H1N1) pdm09 strains isolated in Kenya during 2015-2018 seasons, to evaluate their antigenic and molecular properties based on the HA1 sub-unit. Our analyses revealed that the A (H1N1) pdm09 strains that circulated in Kenya during this period belonged to genetic clade 6B, subclade 6B.1 and 6B.2. The Kenyan 2015 and 2016 isolates differed from the vaccine strain A/California/07/2009 at nine and fourteen antigenic sites in the HA1 respectively. Further, those isolated in 2017 and 2018 correspondingly varied from A/Michigan/45/2015 vaccine strain at three and fifteen antigenic sites. The predicted vaccine efficacy of A/California/07/2009 against Kenyan 2015/2016 was estimated to be 32.4% while A/Michigan/45/2015 showed estimated vaccine efficacies of 39.6% - 41.8% and 32.4% - 42.1% against Kenyan 2017 and 2018 strains, respectively. Hemagglutination-inhibition (HAI) assay using ferret post-infection reference antiserum showed that the titers for the Kenyan 2015/2016 isolates were 2-8-fold lower compared to the vaccine strain. Overall, our results suggest the A (H1N1) pdm09 viruses that circulated in Kenya during 2015/2016 influenza seasons were antigenic variants of the recommended vaccine strains, denoting sub-optimal vaccine efficacy. Additionally, data generated point to a swiftly evolving influenza A (H1N1) pdm09 virus in recent post pandemic era, underscoring the need for sustained surveillance coupled with molecular and antigenic analyses, to inform appropriate and timely influenza vaccine update.

GO O, EK G, S N. "Audit on the management of early rheumatoid arthritis in Nairobi." Afr J Rheumatol. 2020;8(1):22-25. Abstractaudit_on_the_management_of_early_rheumatoid_arthitis_in_nairobi.pdf

Background
: Clinical audit for rheumatoid arthritis on patients over
the age of 18 years in Nairobi, Kenya within the first three months of referral to a specialist. Objective: The audit gives detailed
information on the following; access to care, quality of treatment and
care received by patients from their rheumatology team in these first 3 months and the early impact of arthritis on the patient’s life.
Design: This was a cross-sectional
survey. Results
: The audit included 100 patients referred to the Nairobi Arthritis
Clinic between January and April 2018. A majority (54%) had symptoms for
more than 6 months before being referred to a rheumatologist. Most of
the patients (83%) were seen within 3 weeks of referral. Disease Modifiying
Antirheumatic Drugs (DMARDs) were commenced in 90% within 6 weeks of
being seen at the clinic. Treatment to target was done in 98% of the patients
with a further 60% able to access the clinic within a day of flare of symptoms. Conclusion: The audit revealed the
need to improve on referral time to the rheumatologist. It was encouraging
to note that once they saw the rheumatologists the patients were
commenced on the proper treatment with the treat to target strategy. An area
that needs improvement is the time to access the rheumatologist in case of
side effect from the treatment or flare of the disease

KURIA JOSEPHNGEIK, MOGOI DONALD, GACHUHI SAMUELGUCHU. "Co-infection by dimorphic fungi in tuberculosis patients in Kenya." International Journal of Mycobacteriology. 2020;9:116-120.
Gawriluk TR, Simkin J, Hacker CK, Kimani JM, Kiama SG, Ezenwa VO, Seifert AW. "Complex Tissue Regeneration in Mammals Is Associated With Reduced Inflammatory Cytokines and an Influx of T Cells." Front. Immunol.. 2020;11(1695):1-19.
S D, GO O, V O-H. "Depression and its association with disease activity and quality of life in patients with rheumatoid arthritis at the Kenyatta National Ho." Afr J Rheumatol. 2020;8(1):15-21. Abstractdepression_and_its_association_with_disease_activity.pdf

Background: Rheumatoid arthritis
is a systemic inflammatory disease that affects the synovial membrane,
resulting in the structural damage of cartilage, bone and ligaments. The
course of RA differs between patients, and its severity can range from selflimiting
disease to severe destruction and systemic complications. RA affects
patients physically, psychologically and socially. Patients experience pain,
joint swelling, stiffness, functional limitations and fatigue and overall poor
quality of life. In addition, they report anxiety and depressive symptoms
and concerns about increased physical limitations. Experiencing
psychological distress may inflate the subjective severity of patient-reported
symptoms such as pain and tenderness. Furthermore, patients experience a
loss of independence and restrictions in participation, i.e. a decrease in
socializing which may in turn propagate symptoms of depression. An accurate
description of the relationship between depression, disease severity and quality
of life is necessary for our setting. If an interaction exists, then there is a
group of vulnerable patients who could benefit from earlier identification
of depression and the impact their disease has on HRQoL and appropriate
management provided. Objective: To determine the prevalence
of depression and the relationship between depression, disease activity
and quality of life in ambulatory patients with rheumatoid arthritis at
the Kenyatta National Hospital.Design: A descriptive-cross sectional

Busienei J, Irungu P, Gichungi H, Muriithi B, Diiro G. "Effect of Technological Innovation on Gender Roles: The Case of Fruit Fly IPM Adoption on Women’s Decision‑Making in Mango Production and Marketing in Kenya." The European Journal of Development Research. 2020;10.1057(s41287-020-00282-z).
Maina J, Wandiga S, Gyampoh B, Gachene C. "Effects of Supplemental Irrigation on Crop Yields: Case Study Kales (Brassica Oleracea) Crop." Journal of Ecological Engineering. 2020;(21):209-213. AbstractEcological Engineering

The aim of this study was to investigate the effects that supplemental irrigation (SI) has on Kale (Brassica Oleracea) crop yields as compared to wholly rain-fed crop. The experiments were conducted in Kieni, Central Kenya where the rainfall pattern was bimodal. The planting for rain-fed crops was done in three blocks each measuring 10m x1m with a spacing of 30cm between plants and 45cm between rows of plants and the procedure repeated for the crops receiving SI. The average weekly yields were computed for both crops for each season comprised of 14 weeks. The average weekly yields were subjected to Analysis of Variance (ANOVA) to determine whether the average yields from rain-fed and supplemental irrigated crops were statistically different. This was done by MS Excel 2016 spread sheets by setting a statistical level of significance of 5%. F value was 17.94 higher than the critical value of 4.01 while the P-value of 9x10-5 was lower than the 5% level of confidence meaning that there was a significant difference in the yield means of rain-fed and SI crops. The total rain-fed crop yields for the period was 147.0 Kgs and that of the one under SI was 238Kgs, an increase of about 62%. Therefore, supplemental irrigation can be adopted in areas where rainfall trends are declining to increase crop yields when all other factors remain constant for farmers to increase resilience.

Bauza V, Madadi V, Ocharo R, Nguyen TH, Guest JS. "Enteric pathogens from water, hands, surface, soil, drainage ditch, and stream exposure points in a low-income neighborhood of Nairobi, Kenya." Science of The Total Environment. 2020;709:135344. AbstractScience of The Total Environment

Description
Child exposure to fecal-oral pathogens occurs through several transmission pathways. However, the relative importance of different exposure points for pathogen transmission both inside and outside households is not well understood. We conducted a cross-sectional study in the urban slum of Kibera in Nairobi, Kenya, collecting 237 environmental samples from 40 households from source water, stored drinking water, caregiver hands, child hands, household surfaces, soil, standing water, open drainage ditches, and streams. We quantified the fecal indicator Escherichia coli and the enteric pathogens of adenovirus, Campylobacter jejuni, Shigella spp./enteroinvasive E. coli (EIEC), and Vibrio cholerae. At least one enteric pathogens was detected in 13% of household stored water, 47% of hand, 46% of table surface, 26% of plate surface, 75% of floor surface, 96% of soil, 56% of standing water, 77% of drainage ditch …

Bauza V, Madadi V, Ocharo R, Nguyen TH, Guest JS. "Enteric pathogens from water, hands, surface, soil, drainage ditch, and stream exposure points in a low-income neighborhood of Nairobi, Kenya." Science of The Total Environment. 2020;709(March 2020):135344.
Okumu MO, Mbaria JM, Gikunju JK, Mbuthia PG, Madadi VO, Ochola FO. "Enzymatic activity and brine shrimp lethality of venom from the large brown spitting cobra (Naja ashei) and its neutralization by antivenom." BCM Research Notes. 2020;13(25):1-7.
Bonet M, Brizuela V, Abalos E, Cuesta C, Baguiya A, Group TWHOGMSS(GLOSS) R. "Frequency and management of maternal infection in health facilities in 52 countries: Results of the WHO Global Maternal Sepsis Study (GLOSS), a one-week inception cohort." Lancet Global Health. . 2020;8(5):661-671. AbstractWebsite

Background
Maternal infections are an important cause of maternal mortality and severe maternal morbidity. We report the main findings of the WHO Global Maternal Sepsis Study, which aimed to assess the frequency of maternal infections in health facilities, according to maternal characteristics and outcomes, and coverage of core practices for early identification and management.
Methods
We did a facility-based, prospective, 1-week inception cohort study in 713 health facilities providing obstetric, midwifery, or abortion care, or where women could be admitted because of complications of pregnancy, childbirth, post-partum, or post-abortion, in 52 low-income and middle-income countries (LMICs) and high-income countries (HICs). We obtained data from hospital records for all pregnant or recently pregnant women hospitalised with suspected or confirmed infection. We calculated ratios of infection and infection-related severe maternal outcomes (ie, death or near-miss) per 1000 livebirths and the proportion of intrahospital fatalities across country income groups, as well as the distribution of demographic, obstetric, clinical characteristics and outcomes, and coverage of a set of core practices for identification and management across infection severity groups.
Findings
Between Nov 28, 2017, and Dec 4, 2017, of 2965 women assessed for eligibility, 2850 pregnant or recently pregnant women with suspected or confirmed infection were included. 70·4 (95% CI 67·7–73·1) hospitalised women per 1000 livebirths had a maternal infection, and 10·9 (9·8–12·0) women per 1000 livebirths presented with infection-related (underlying or contributing cause) severe maternal outcomes. Highest ratios were observed in LMICs and the lowest in HICs. The proportion of intrahospital fatalities was 6·8% among women with severe maternal outcomes, with the highest proportion in low-income countries. Infection-related maternal deaths represented more than half of the intrahospital deaths. Around two-thirds (63·9%, n=1821) of the women had a complete set of vital signs recorded, or received antimicrobials the day of suspicion or diagnosis of the infection (70·2%, n=1875), without marked differences across severity groups.
Interpretation
The frequency of maternal infections requiring management in health facilities is high. Our results suggest that contribution of direct (obstetric) and indirect (non-obstetric) infections to overall maternal deaths is greater than previously thought. Improvement of early identification is urgently needed, as well as prompt management of women with infections in health facilities by implementing effective evidence-based practices.

SM Mwendwa, Mbuvi JP, Kironchi G, Gachene CKK. "A geopedological approach to soil classification to characterize soils of Upper Kabete Campus Field, University of Nairobi, Kenya ." Tropical and Subtropical Agroecosystems. 2020.
SM Mwendwa, Mbuvi JP, Kironchi G, Gachene CKK. "A geopedological approach to soil classification to characterize soils of Upper Kabete Campus Field, University of Nairobi, Kenya ." Tropical and Subtropical Agroecosystems. 2020.
Mitchell EJ, Benjamin S, Ononge S, Ditai J, QURESHI ZAHIDA, Masood SN, Whitham D, Godolphin PJ, Duley L. "Identifying women giving birth preterm and care at the time of birth: a prospective audit of births at six hospitals in India, Kenya, Pakistan and Uganda." BMC Pregnancy Childbirth . 2020;20(439). AbstractWebsite

Background
Globally, 15 million infants are born preterm each year, and 1 million die due to complications of prematurity. Over 60% of preterm births occur in Sub-Saharan Africa and south Asia. Care at birth for premature infants may be critical for survival and long term outcome. We conducted a prospective audit to assess whether women giving birth preterm could be identified, and to describe cord clamping and neonatal care at hospitals in Africa and south Asia.

Methods
This prospective audit of livebirths was conducted at six hospitals in Uganda, Kenya, India and Pakistan. Births were considered preterm if between 28+ 0 and 33+ 6 weeks gestation and/or the birthweight was 1.00 to 1.99 kg. A pre-specified audit plan was agreed with each hospital. Livebirths before 28 weeks gestation with birthweight less than 1.0 kg were excluded. Data were collected on estimated and actual gestation and birthweight, cord clamping, and neonatal care.

Results
Of 4149 women who gave birth during the audit, data were available for 3687 (90%). As 107 were multiple births, 3781 livebirths were included, of which 257 (7%) were preterm. Antenatal assessment correctly identified 148 infants as ‘preterm’ and 3429 as ‘term’, giving a positive predictive value of 72% and negative predictive value of 97%. For term births, cord clamping was usually later at the two Ugandan hospitals, median time to clamping 50 and 76 s, compared with 23 at Kenyatta (Kenya), 7 at CMC (India) and 12 at FBH/LNH (Pakistan). At the latter two, timing was similar between term and preterm births, and between vaginal and Caesarean births. For all the hospitals, the cord was clamped quickly at Caesarean births, with Mbale (Uganda) having the highest median time to clamping (15 s ‘term’, 19 ‘preterm’). For preterm infants temperature on admission to the neonatal unit was below 35.5 °C for 50%, and 59 (23%) died before hospital discharge.

Conclusions
Antenatal identification of preterm birth was good. Timing of cord clamping varied between hospitals, although at each there was no difference between ‘term’ and ‘preterm’ births. For premature infants hypothermia was common, and mortality before hospital discharge was high.

S. S, Gitau G.K., J. VL, C. M, P. K. "Impact of calf feeding practices on calf growth and health in smallholder dairy farms in Nyeri County, Kenya." East African Journal of Science, Technology, and Innovation. 2020;1(3):2707-0425.
Nyang'au P, Muriithi B, Nzuma J, Irungu P, Gichungi H, Diiro G. "Impact of Integrated Fruit Fly Management Strategy on Food Security among Smallholder Mango Farmers in Kenya." African Journal of Food, Agriculture, Nutrition and Development. 2020;20(2):15431-15454.
Guthua SW, Kamau M, ABINYA N. "Management of Maxillofacial of Osteosarcomas in Kenya: A case Series." The Annals of African Surgery. 2020;17 (1).
Nambati EA, Njoka M, Eyase F, Majanja J, Njuguna N, Gitonga SM, Mwikwabe N, Lelo E, Mwangi M, kingoro A, Kimani F, Lubano K, Bulimo W. "Multidisciplinary approach towards training of the next generation of forensic DNA analysts in Africa; a Kenyan perspective." Forensic Science International: Synergy. 2020;2:123-125. Abstract1-s2.0-s2589871x20300267-main.pdfWebsite

The uptake of forensic DNA testing technologies in Africa has been slow despite the revolutionary technology being discovered and adopted 3 decades ago. African governments and partners have invested in construction and equipping of forensic laboratories in Africa but the benefits are yet to be realised as the laboratories are still faced with the challenge of shortage of adequately trained personnel. This paper describes an innovative multidisciplinary training approach that was developed and used to train officers from the Directorate of Criminal Investigations Kenya. We report on the structure, implementation and effectiveness of the training. It is expected that with the increased number of trained forensic DNA analysts, there will be an improvement in quality of forensic DNA evidence presented in courts and a reduction in backlog in the forensic biology laboratories in Kenya.

IRIBEMWANGI PI, Gaithuma VW. "Phonological Influence of Kiamu dialect to Amu Learners of Standard Kiswahili - Expected." Jarida la Kimataifa la Isimu ya Kibantu (JAKIIKI). 2020.
O. A’G, T. M, W. OM, F. N’ang’a, G. O’P, M. MD, D. M, M. A, S G. "Phytochemicals in leaves and roots of selected Kenyan orange fleshed Sweet potato (OFSP) varieties. International Journal of Food Science." International Journal of Food Science . 2020;2020(1-2):1-11.
Mbindyo C, Gitao C, Mulei C. "Prevalence, Etiology, and Risk Factors of Mastitis in Dairy Cattle in Embu and Kajiado Counties, Kenya." Veterinary Medicine International. 2020;Volume 2020 |Article ID 8831172 | 12 pages (https://doi.org/10.1155/2020/8831172):12 pages.
Gathumbi JK, Kemboi DC, Antonissen G, Ochieng PE, Croubels S, Kangethe EK, Okoth S, Faas J, Lindahl JF. "A Review of the Impact of Mycotoxins on Dairy Cattle Health: Challenges for Food Safety and Dairy Production in Sub-Saharan Africa." Toxins 2020. 2020;12(4).
J.O'Connell P, Brown M, Chan TM, Granado RC-D, J.Davies S, Eiam-Ong S, H.Hassan M, Kalantar-Zadeh K, Levin A, E.Martin D, Muller E, Ossareh S, Tchokhonelidze I, Trask M, Twahir A, J.O.Were A, Yang C-W, Zemchenkov A, N.Harden P. "The role of kidney transplantation as a component of integrated care for chronic kidney disease." Science Direct. 2020.Website
E.S. K, G. G, J. VL, P. K, T.O. A, D. G, J. M, D. M. "Sero-prevalence and risk factors of infectious bovine rhinotracheitis virus (type 1) in Meru County, Kenya." Preventive Veterinary Medicine . 2020;175:104863.
Kipyego ES, Gitau G, Vanleeuwen J, Kimeli P, Abuom TA, Gakuya D, Muraya J, Makau D. "Sero-prevalence and risk factors of Infectious rhinotracheatis virus( type1) in Meru county, Kenya." Preventive Veterinary Medicine . 2020;104863.(175).
Awili H, Gitao C, Muchemi G. "Seroprevalence and Risk Factors for Hepatitis B Virus Infection in Adolescent Blood Donors within Selected Counties of Western Keny." Hindawi BioMed Research International. 2020;Volume 2020, Article ID 8578172,: 6 pages.
W1 G, Ongondi M2, GO1 O. "Treatment Approaches for Multiple Myeloma: A Review." Journal of Kenya Association of Physicians. 2020;3(1):29-34.
Chiorean GE, Nandakumar G, Fadelu T, Temin S, Alarcon-Rozas AE, Bejarano S, Croitoru A-E, Grover S, Lohar PV, Odhiambo A, Park SH, Garcia ER, Teh C, Rose A, Zaki B, Chamberlin MD. "Treatment of Patients With Late-Stage Colorectal Cancer: ASCO Resource-Stratified GuidelineTreatment of Patients With Late-Stage Colorectal Cancer: ASCO Resource-Stratified Guideline." Journal of Global Oncology. 2020;6(2020):414-438.
Galvin KA, Trevor Even, Robin S. Reid, Jesse Njoka, Joana Roque de Pinho, Philip Thornton, Saylor K. "Understanding Climate from the Ground Up: Knowledge of Environmental Changes in the East African Savannas." Changing Climate, Changing Worlds. 2020:221-242.
Gatere Lucy Njeri, Omboga Zaja and Rayya Timmamy. "Usawiri wa Familia ya Kisasa katika Fasihi ya Watoto Nchini Kenya, ." Mwanga wa Lugha, Jarida la Idara ya Kiswahili na Lugha Nyingine za Kiafrika, Chuo Kikuu cha Moi. 2020;Juzuu 5,(Na.1, April 2020,):185-196.
Atsango EW, Muiru WM, Mwang’ombe A, Gaoqiong L. "Use Of Amino Oligosacharins And Alternaria Fine Protein In The Management Of Crown Gall Disease On Roses." Researchjournali’s Journal of Agriculture. 2020;Vol. 7,( No. 1 January).use_of_amino_oligosacharins_and_alternaria_fine_protein.pdf
A N, GO O, C O. "The use of musculoskeletal ultrasound of the wrist and hand in the assessment of treatment response in rheumatoid arthritis patients." Afr J Rheumatol. 2020;8(1):3-7. Abstract

Objective: Rheumatoid arthritis is a
debilitating disease with accrual of joint damage during each flare of the disease that progresses to considerable functional disability. Early treatment is
thus aimed to achieve remission status so as to reduce the progression of joint
damage. Currently the disease activity parameter DAS28 (amongst others)
is used to define a remission status and thus demonstrate the efficacy
of a treatment regimen, however musculoskeletal ultrasound (MSUS) is
proving to be superior at determining the amount of inflammation within joints by grading synovial hypertrophy and neo-vascularization of the
inflamed synovium. This article is thus intended to shed light on the usefulness of musculoskeletal ultrasound
both greyscale and Doppler in the determination of treatment response
in rheumatoid arthritis patients. Design: This article will elaborate
the importance and effectiveness of musculoskeletal ultrasound. Thus it will involve a discussion on the need for an effective tool to detect inflammatory activity, the ability of ultrasound to detect and grade the disease activity i.e.
being sensitive to change, the various scoring systems currently used, and
lastly a comparison of musculoskeletal ultrasound to other modalities and
clinical and serological evaluation. Data source and extraction:
Published studies, reviews and guidelines regarding the use of
musculoskeletal ultrasound of the wrist/hand in assessing treatment
response in rheumatoid arthritis patients were sourced through the
internet and library searches and the relevant data extracted. Conclusion:
status of the patient or a high initial ESR with significant serological and clinical
improvement, which will again not be portrayed in the DAS28 results. There may also be variability when assessing joints that are swollen or tender in between different examiners4. Moreover, there is a subset of
patients who still have disease progression despite achieving clinical remission status5.
  Magnetic Resonance Imaging (MRI) and radiographic evaluation have also been used as adjuncts to clinical exam but both have their drawb

2019
Gichuyia LN. "INDOOR OVERHEATING RISK ANALYSIS OF OFFICE BUILDINGS IN NAI- ROBI IN A CHANGING CLIMATE.". In: Annual Eastern Africa Architecture Workshop and Exhibition. ADD Building - University of Nairobi; 2019.
Gichuyia LN. "LESSONS LEARNT FROM THERMAL DATA-LOGGING OF BUILDINGS IN NAIROBI OVER THE YEARS; HIGHLIGHT- ING THE DEMAND FUNCTIONS FOR DECI- SION-SUPPORT.". In: Annual Eastern Africa Architecture Workshop and Exhibition. ADD Building - University of Nairobi; 2019.
Karimurio J, Gichuhi S, Nyamori J, Gachago M, Rono H, Gichangi M, Mwangi A, Kefa R. "Is task-shifting of screening for diabetic retinopathy (DR) from eye specialists to technicians accurate?". In: East African Community East African Health Research Commission 7th East African Health and Scientific Conference. Dar es Salaam; 2019.invitation_letter_7th_eahsc_pg1_jefitha_karimurio1.pdfuse_of_technology_to_taskshift__prof_jefitha_karimurio.pdf
Gitao, C.G., Toroitich, K, Khalif, Field, C, Wario, S. Mass Livestock Deaths In EL-HADI Of North-Horr Sub-County, MARSABIT COUNTY. Nairobi: RPLP; 2019.marsabit_camel_deaths-paper_-1.docx
Gitao C. "Role of Academia and Researchers in the Agricultural sector in Kenya’.". In: Kenya Private Sector Agricultural sector. Intercontinental Hotel, Nairobi; 2019.
Gichuyia LN. "THE IMPACT OF CLIMATE CHANGE ON THE INDOOR OVERHEATING RISK LANDSCAPE OF NAIROB.". In: In Proceedings of the Annual Architecture and Engineering Conference - Business opportunities in Energy, Manufacturing, Infrastructural and Environmental Research. School of Engineering, University of Nairobi, Kenya; 2019.
Arunga S, Kintoki GM, Gichuhi S, Onyango J, Ayebazibwe B, Newton R, Leck A, Macleod D, Hu VH, Burton MJ. "Risk Factors of Microbial Keratitis in Uganda: A Case Control Study." Ophthalmic Epidemiol. 2019:1-7. AbstractWebsite

Purpose: Microbial keratitis (MK), is a frequent cause of sight loss worldwide, particularly in low and middle-income countries. This study aimed to investigate the risk factors of MK in Uganda.
Methods: Using a nested case control, we recruited healthy community controls for patients presenting with MK at the two main eye units in Southern Uganda between December 2016 and March 2018. Controls were individually matched for age, gender and village of the cases on a 1:1 ratio. We collected information on demographics, occupation, HIV and Diabetes Mellitus status. In STATA version 14.1, multivariable conditional logistic regression was used to generate odds ratios for risk factors of MK and a likelihood ratio test used to assess statistical significance of associations.
Results: Two hundred and fifteen case-control pairs were enrolled. The HIV positive patients among the cases was 9% versus 1% among the controls, = .0003. Diabetes 7% among the cases versus 1.4% among the controls, = .012. Eye trauma was 29% versus 0% among the cases and controls. In the multivariable model adjusted for age, sex and village, HIV (OR 83.5, 95%CI 2.01-3456, = .020), Diabetes (OR 9.38, 95% CI 1.48-59.3, = .017) and a farming occupation (OR 2.60, 95%CI 1.21-5.57, = .014) were associated with MK. Compared to a low socio-economic status, a middle status was less likely to be associated with MK (OR 0.29, 95%CI 0.09-0.89, < .0001).
Conclusion: MK was associated with HIV, Diabetes, being poor and farming as the main occupation. More studies are needed to explore how these factors predispose to MK.

Arunga S, Kintoki GM, Gichuhi S, Onyango J, Newton R, Leck A, Macleod D, Hu VH, Burton MJ. "Delay Along the Care Seeking Journey of Patients with Microbial Keratitis in Uganda." Ophthalmic Epidemiol. 2019:1-10. AbstractWebsite

PURPOSE:To describe the care seeking journey and causes of delay among patients with Microbial Keratitis in Uganda.
METHODS:A prospective cohort of patients presenting with microbial keratitis at the two main eye units in Southern Uganda (2016-2018). We collected information on demographics, home address, clinical history, and presentation pathway including, order of facilities where patients went to seek care, treatment advice, cost of care, and use of Traditional Eye Medicine. Presentation time was noted. We compared "direct" presenters versus "indirect" presenters and analysed predictors of delay.
RESULTS: About 313 patients were enrolled. All were self-referred. Only 19% of the patients presented directly to the eye hospital. Majority (52%) visited one facility before presenting, 19% visited two facilities, 9% visited three facilities, and 2% visited four facilities. The cost of care increased with increase in the number of facilities visited. People in a large household, further distance from the eye hospital and those who used Traditional Eye Medicine were less likely to come directly to the eye hospital. Visiting another facility prior to the eye hospital and use of Traditional Eye Medicine aOR 1.58 (95%CI 1.03-2.43), p = .038 were associated with delayed presentation to the eye hospital.
CONCLUSION: This study provided information on patient journeys to seek care. Delay was largely attributable to having visited another health facility: a referral mechanism for microbial keratitis was non-existent. There is need to explore how these health system gaps can be strengthened.

Ampt FH, Lim MSC, Agius PA, Chersich MF, Manguro G, Gichuki CM, Stoové M, Temmerman M, Jaoko W, Hellard M, Gichangi P, Luchters S. "Use of long-acting reversible contraception in a cluster-random sample of female sex workers in Kenya." Int J Gynaecol Obstet. 2019. Abstract

To assess correlates of long-acting reversible contraceptive (LARC) use, and explore patterns of LARC use among female sex workers (FSWs) in Kenya.

Marangu D, Gray D, Vanker A, Zampoli M. "Exogenous lipoid pneumonia in children: A systematic review." Paediatr Respir Rev. 2019. Abstract

To describe the clinical-radiological-pathological characteristics and treatment outcomes of children with suspected exogenous lipoid pneumonia (ELP).

Rono H, Bastawrous A, Macleod D, Wanjala E, Gichuhi S, Burton M. "Peek Community Eye Health - mHealth system to increase access and efficiency of eye health services in Trans Nzoia County, Kenya: study protocol for a cluster randomised controlled trial." Trials. 2019;20(1):502. AbstractWebsite

Globally, eye care provision is currently insufficient to meet the requirement for eye care services. Lack of access and awareness are key barriers to specialist services; in addition, specialist services are over-utilised by people with conditions that could be managed in the community or primary care. In combination, these lead to a large unmet need for eye health provision. We have developed a validated smartphone-based screening algorithm (Peek Community Screening App). The application (App) is part of the Peek Community Eye Health system (Peek CEH) that enables Community Volunteers (CV) to make referral decisions about patients with eye problems. It generates referrals, automated short messages service (SMS) notifications to patients or guardians and has a program dashboard for visualising service delivery. We hypothesise that a greater proportion of people with eye problems will be identified using the Peek CEH system and that there will be increased uptake of referrals, compared to those identified and referred using the current community screening approaches.

Arunga S, Wiafe G, Habtamu E, Onyango J, Gichuhi S, Leck A, Macleod D, Hu V, Burton M. "The impact of microbial keratitis on quality of life in Uganda." BMJ Open Ophthalmol. 2019;4(1):e000351. AbstractWebsite

Background: Microbial keratitis (MK) is a frequent cause of sight loss in sub-Saharan Africa. However, no studies have formally measured its impact on quality of life (QoL) in this context.
Methods: As part of a nested case-control design for risk factors of MK, we recruited patients presenting with MK at two eye units in Southern Uganda between December 2016 and March 2018 and unaffected individuals, individually matched for sex, age and location. QoL was measured using WHO Health-Related and Vision-Related QoL tools (at presentation and 3 months after start of treatment in cases). Mean QoL scores for both groups were compared. Factors associated with QoL among the cases were analysed in a linear regression model.
Results: 215 case-controls pairs were enrolled. The presentation QoL scores for the cases ranged from 20 to 65 points. The lowest QoL was visual symptom domain; mean 20.7 (95% CI 18.8 to 22.7) and the highest was psychosocial domain; mean 65.6 (95% CI 62.5 to 68.8). At 3 months, QoL scores for the patients ranged from 80 to 90 points while scores for the controls ranged from 90 to 100. The mean QoL scores of the cases were lower than controls across all domains. Determinants of QoL among the cases at 3 months included visual acuity at 3 months and history of eye loss.
Conclusion: MK severely reduces QoL in the acute phase. With treatment and healing, QoL subsequently improves. Despite this improvement, QoL of someone affected by MK (even with normal vision) remains lower than unaffected controls.

Dean W, Gichuhi S, Buchan J, Matende I, Graham R, Kim M, Arunga S, Makupa W, Cook C, Visser L, Burton M. "Survey of ophthalmologists-in-training in Eastern, Central and Southern Africa: A regional focus on ophthalmic surgical education." Wellcome Open Res. 2019;4:187. AbstractWebsite

There are 2.7 ophthalmologists per million population in sub-Saharan Africa, and a need to train more. We sought to analyse current surgical training practice and experience of ophthalmologists to inform planning of training in Eastern, Central and Southern Africa. This was a cross-sectional survey. Potential participants included all current trainee and recent graduate ophthalmologists in the Eastern, Central and Southern African region. A link to a web-based questionnaire was sent to all heads of eye departments and training programme directors of ophthalmology training institutions in Eastern, Central and Southern Africa, who forwarded to all their trainees and recent graduates. Main outcome measures were quantitative and qualitative survey responses. Responses were obtained from 124 (52%) trainees in the region. Overall level of satisfaction with ophthalmology training programmes was rated as 'somewhat satisfied' or 'very satisfied' by 72%. Most frequent intended career choice was general ophthalmology, with >75% planning to work in their home country post-graduation. A quarter stated a desire to mainly work in private practice. Only 28% of junior (first and second year) trainees felt surgically confident in manual small incision cataract surgery (SICS); this increased to 84% among senior trainees and recent graduates. The median number of cataract surgeries performed by junior trainees was zero. 57% of senior trainees were confident in performing an anterior vitrectomy. Only 29% of senior trainees and 64% of recent graduates were confident in trabeculectomy. The mean number of cataract procedures performed by senior trainees was 84 SICS (median 58) and 101 phacoemulsification (median 0). Satisfaction with post-graduate ophthalmology training in the region was fair. Most junior trainees experience limited cataract surgical training in the first two years. Focused efforts on certain aspects of surgical education should be made to ensure adequate opportunities are offered earlier on in ophthalmology training.

Sorensen, Olago, D. O., Dulo, Kanoti, Gaye, Faye, Pouye, Owor. "Real-time indication of faecally contaminated drinking water with fluorescence spectroscopy: towards understanding the causation.". In: 10th International Groundwater Quality Conference (GQ 2019). Liège, Belgium; 2019.
Gathumbi JK, Kimani, J.M., Mutisya P, Kombe, Yeri, Wamunyokoli, Fred W, Mbakaya, Charles FL. "The Additive Effect of Hepatitis B Virus and Aflatoxin B1 to Liver Disease Burden: A Case Study in Kitui, Makueni and Machakos Counties, Kenya." Journal of Health and Medical Sciences. 2019;2(3):312-331.
KJ G, AM M, GO A’. "ANAEMIA AMONG BREASTFEEDING INFANTS (0-6 MONTHS) AND ASSOCIATED FACTORS IN A LOW INCOME URBAN SETTING OF KENYA." African Journal of Food , Agriculture,Nutrition and Development. 2019;19(2):14303-14319.
Maina J, Wandiga S, Gyampoh B, KK GC. "Analysis of Average Annual Rainfall and Average Maximum Annual Temperature for a Period of 30 years to Establish Trends in Kieni, Central." Journal of Climatol Weather Forecasting. 2019;7:249. Abstractwww.longdom.org

The aim of the study was to analyze average annual rainfall and average maximum annual temperature records for
30 years in the study area to establish trends hence confirm the presence or absence of climate change. The analysis
was accomplished with the use of MS Excel spreadsheets. The meteorological datasets were 1984-2013 records for
rainfall and 1981-2012 for temperature. The rainfall climatological standard normal was computed for a 25-year
period between 1989 and 2012 which was used to compute the average annual rainfall anomaly. The temperature
provisional normal was computed for a period of 10 years due to lack of adequate data. The average annual rainfall
anomaly for 1984-2013 periods was -8.8 mm an indication of a declining rainfall trend while the annual maximum
temperature for 1981-2012 period was 0.5°C a positive trend showing that the annual maximum temperatures
are rising in the study area. Therefore, the declining average annual rainfall accompanied with rising maximum
temperatures were indicators of the presence of climate change.

Keywords: Average annual rainfall; Average maximum temperature; Trends; Climatological standard normal;
Datasets; Climate change

Omole RA, Moshi MJ, Heydenreich M, Malebo HM, Gathirwa JW, Oriko RO, Omosa LK, Midiwo JO. "Antiplasmodial Biflavanones from the Stem Bark of Garcinia buchananii Engl." Pharmacognosy Communications. 2019;9(3):96-99.
Omole RA, Moshi MJ, Heydenreich M, Malebo HM, Gathirwa JW, Oriko RO, Omosa LK, Midiwo JO. "Antiplasmodial Biflavanones from the Stem Bark of Garcinia buchananii Engl." Pharmacognosy Communications. 2019;9(3):96-99. AbstractJournal article

Description
Introduction: Plants of the genus Garcinia are traditionally used treat a range of infectious and non-infectious diseases. Garcinia species are reported to have been shown to have a range of biological activities including cytotoxicity antimicrobial, antifungal, antioxidant, antimalarial and HIV-1 protease inhibitory activity among others. Methods: Solvent extraction was done using CH2Cl2: MeOH (1: 1). Isolation was done using column chromatography with silica gel as the stationery phase and ethyl acetate and n-hexane used as mobile phase in increasing polarity. Thin layer chromatography was used to monitor the isolation. Structure elucidation was done using nuclear magnetic resonance and mass spectroscopic techniques. Chloroquine resistant (W2) and chloroquine sensitive (D6) P. falciparum strains were used for antiplasmodial assay. Results: Further bioassay guided fractionation of a CH2Cl2: MeOH (1: 1) extract of Garcinia buchananii led to the isolation of two already reported biflavanones, isogarcinol (1) and guttiferone (2) with promising antiplasmodial activity against a chloroquine resistant (W2) Plasmodium falciparum strain with an IC50 of 2.8
±0.90 µg/mL for compound 1 and IC50 of 3.94±0.38 µg/mL for compound 2. Compounds 1 and 2 also exhibited moderate activity against the chloroquine sensitive (D6) Plasmodium falciparum strain with IC50 of 7.03±0.60 and 10.64±4.50 µg/mL, respectively. Conclusion: The results provide proof to support the use of G. buchananii by the indigenous community for antimalarial therapy.
Scholar articles
Antiplasmodial Biflavanones from the Stem Bark of Garcinia buchananii Engl.
RA Omole, MJ Moshi, M Heydenreich, HM Malebo… - Pharmacognosy Communications, 2019
All 4 versions

Gitau PW, Kunyanga CN, Abong’ GO, Ojiem JO, Muthomi JW. "Assessing Sensory Characteristics and Consumer Preference of Legume-Cereal-Root Based Porridges in Nandi County." Journal of Food Quality. 2019;https://doi.org/10.1155/2019/3035418.
Bebora L.C, Gitao CG, P.M M, Mobegi VA, Shumbusho B, Iraguha B. "Assessment of bacterial contamination and milk handling practices along the raw milk market chain in the North-Western region of Rwanda." African Journal of Microbiology Research. 2019;13(29):640-648.abstract.pdf
Mpatswenumugabo, JP, Bebora LC, Gitao, C.G., Kamana, O, Mobegi, VA, Irahuga B, B S. "Assessment of Bacterial contaminations andmilk handling practices along the raw milk market chain in North-western region of Rwanda." African Journal of Microbiology Research. 2019;13(29 ;http://dx.doi.org/10.5897/AJMR2018.8919 ):640-648.second_paper_published-jean_pierre.pdf
Efferth T, Banerjee M, Abu-Darwish MS, Abdelfatah S, Böckers M, Bhakta-Guha D, Bolzani V, Daak S, Demirezer LÖmür, Dawood M, Efferth M, El-Seedi HR, Fischer N, Greten HJ, Hamdoun S, Hong C. "Biopiracy versus One-World Medicine–From colonial relicts to global collaborative concepts." Phytomedicine. 2019;53:319-331. Abstract

Background
Practices of biopiracy to use genetic resources and indigenous knowledge by Western companies without benefit-sharing of those, who generated the traditional knowledge, can be understood as form of neocolonialism.
Hypothesis
The One-World Medicine concept attempts to merge the best of traditional medicine from developing countries and conventional Western medicine for the sake of patients around the globe.
Study design
Based on literature searches in several databases, a concept paper has been written. Legislative initiatives of the United Nations culminated in the Nagoya protocol aim to protect traditional knowledge and regulate benefit-sharing with indigenous communities. The European community adopted the Nagoya protocol, and the corresponding regulations will be implemented into national legislation among the member states. Despite pleasing progress, infrastructural problems of …

Gichuyia LN. BOOSTING INTERCON- TINENTAL RELATIONS _ LESSONS FROM BUILDING PHYSICS. Wilhelm Kempff house- Casa Orfeo, Positano -Italy,; 2019.
Odhiambo SA, ZP Q, PM N, Kosgei RJ, AB K, Ayieko P, PK K, A O, Odawa FX, GN G, MK K, O K, O O. "Born Too Soon: Provide Corticosteriods at the earliest opportunity even if dose is not completed." Journal of Obstetrics and Gynaecology of East & Central Africa. 2019;30(2):62-63.Website
Willis N Ochilo, Gideon N Nyamasyo, Dora Kilalo WOMOFCTKELK. "Characteristics and production constraints of smallholder tomato production in Kenya." Scientific African. 2019;2:e00014.
Willis N Ochilo, Gideon N Nyamasyo, Dora Kilalo WOMOFCTKELK. "Characteristics and production constraints of smallholder tomato production in Kenya." Scientific African. 2019;2:e00014.
M.W. W, Hansted L, Gikungu M, G K, AS B. "Characterization of Kenyan Honeys Based on Their Physicochemical Properties, Botanical and Geographical Origin." International Journal of Food Science . 2019;2019(2932509):10.
Mary Wanjiru Warui 1, Lise Hansted 2, Mary Gikungu 3, John Mburu 4, Geoffrey Kironchi 1, Bosselmann5 AS. "Characterization of Kenyan honeys based on their physicochemical properties, botanical and geographical origin." International journal of food science. 2019.
Agesa BL, Onyango CM, M KV, Onwonga RN, GN K. "Climate Change Effects on Crop Production in Yatta sub-County: Farmer Perceptions and Adaptation Strategies." African Journal of Food, Agriculture, Nutrition and Development. 2019;19(1):14010-14042.
Mwaniki, S.W, Gakuya, F., Mwaura, F., Muthama, J.M. "Collaborative Governance for Sustainable Delivery of Public Open Spaces in Nairobi City, East African Journal of Science." Journal of Science, Technology and Innovation. 2019.
Muasya  D, Gitau G, Thaiyah G, Gakuya D, Vanleeuwen J, Mbatha P. "A comparison between indirect ELISA and tuberculin skin test in the diagnosis of bovine tuberculosis in Kenya.". 2019.
OMAYIO DUKEG, Abong’ GO, Okoth MW, GACHUIRI CHARLESK, Mwang’ombe AW. "Current Status of Guava (Psidium Guajava L.) Production, Utilization, Processing and Preservation in Kenya." Current Agriculture Research Journal. 2019;Vol. 7,( No.(3) 2019, ):pg. 318-331.current_status_of_guava_psidium_guajava_l._production_utilization_processing_and_preservation_in_kenya.pdf
Odhiambo SA, ZP Q, PM N, Kosgei RJ, AB K, Ayieko P, PK K, A O, Odawa FX, GN G, MK K, O K, O O. "Early Neonatal Outcomes among Mothers receiving variable doeses of Dexamethasone for Preterm Premature Rupture of Membranes at Kenyatta National Hospital: A restrospective Cohort Study ." Journal of Obstetrics and Gynaecology of East & Central Africa. 2019;30(2):54-61.Website
Githanga D. "The effects of aflatoxin exposure on Hepatitis B-induced immunity in Kenyan children." Curr Probl Pediatr Adolesc Health Care 2019. 2019:1-14. Abstractresearchgate

Background: Globally, approximately three million children die each year from vaccine preventable infectious diseases mainly in developing countries. Despite the success of the expanded immunization program, not all infants and children around the world develop the same protective immune response to the same vaccine. A vaccine must induce a response over the basal immune response that may be driven by population-specific, environmental or socio-economic factors. Mycotoxins like aflatoxins are immune suppressants that are confirmed to interfere with both cell-mediated and acquired immunity. The mechanism of aflatoxin toxicity is through the binding of the bio-activated AFB1-8, 9-epoxide to cellular macromolecules. Methods: We studied Hepatitis B surface antibodies [anti-HBs] levels to explore the immune modulation effects of dietary exposure to aflatoxins in children aged between one and fourteen years in Kenya. Hepatitis B vaccine was introduced for routine administration for Kenyan infants in November 2001. To assess the effects of aflatoxin on immunogenicity of childhood vaccines Aflatoxin B1-lysine in blood serum samples were determined using High Performance Liquid Chromatography with Fluorescence detection while anti-HBs were measured using Bio-ELISA anti-HBs kit. Results: The mean § SD of AFB1-lysine adducts in our study population was 45.38 § 87.03 pg/mg of albumin while the geometric mean was 20.40 pg/mg. The distribution of AFB1-lysine adducts was skewed to the right. Only 98/205 (47.8%) of the study population tested positive for Hepatitis B surface antibodies. From regression analysis, we noted that for every unit rise in serum aflatoxin level, anti-HBs dropped by 0.91 mIU/ml (¡0.9110038; 95% C.I ¡1.604948,¡0.21706). Conclusion: Despite high coverage of routine immunization, less than half of the study population had developed immunity to HepB. Exposure to aflatoxin was high and weakly associated with low anti-HBs antibodies. These findings highlight a potentially significant role for environmental factors that may contribute to vaccine effectiveness warranting further research.

W.A 1. O, GN C’wa, J.I K, P.N N. "Effects of Azolla and inorganic nitrogen application on growth and yield of rice in Mwea Irrigation Scheme." International Journal of Agronomy and Agricultural Research. 2019;14 (3):1-8.
W.A 1. O, GN C’wa, J.I K, P.N N. "Effects of inorganic nutrient P and N application on Azolla biomass growth and nutrient uptake." International Journal of Agronomy and Agricultural Research. 2019;14 (02):1-9.
Ogolla KO, Chebet J, Waruiru RM, Gathumbi PK, Okumu PO, Aboge GO. "Efficacy of Ivermectin, Liquid Paraffin, and Carbaryl against Mange of Farmed Rabbits in Central Kenya." Journal of Tropical Medicine. 2019;130:1487-1504.
Waruiru RM, Gathumbi PK, Okumu PO, Ogolla KO, Chebet J, Aboge GO. "Efficacy of ivermectin, liquid paraffin, and carbaryl against mange of farmed rabbits in central Kenya." Hindawi Journal of Tropical Medicine.. 2019;2019.
Ogolla KO, Chebet J, Waruiru RM, Gathumbi PK, Okumu PO, Aboge GO. "Efficacy of Ivermectin, Liquid Paraffin, and Carbaryl against Mange of Farmed Rabbits in Central Kenya." Journal of Tropical Medicine . 2019;Volume 2019, Article ID 5092845(https://doi.org/10.1155/2019/5092845).
Mundia J, Makunda C, Maina SM, Gachie SN. "An Evaluation of Interior Styles in the Serviced Apartment Sector in Nairobi." Africa Design Review Journal. 2019;1(1):54-73.
P. K, D. M, J. VL, G. G, J. M, S. M, L. H. "Factors associated with leg cleanliness of smallholder dairy herds in Kenya." East African Journal of Science, Technology and Innovation. 2019;1(1):11-26.
Gerrard CM, Wanjohi JM. "Factors influencing the implementation of prisons health projects in Kenya: A case of prisons in Meru region." International Academic Journal of Information Sciences and Project Management. 2019;3(3):185-209. AbstractInternational Academic Journal of Information Sciences and Project Management

Description
The prisons departments have been working with Non-Governmental Medical Organizations to implement health projects within the prison’s facilities in Kenya in order to improve the health of prisoners. However, successful implementation of health projects is a common problem in the Kenya Prisons Service not only with an immeasurable cost to society who benefits from these projects within the prisons but also with debilitating effects on the inmates. The purpose of this study was to determine factors influencing the implementation of prisons health projects in Kenya, Meru region Prisons. The study sought to achieve the following objectives; to evaluate the extent to which technical capacity, stakeholders’ involvement, source of funding and prisons leadership influences implementation of prisons health projects in the Kenya, Meru Region Prisons. The study was grounded on resource base view theory, agency theory, stakeholder’s theory and strategic leadership theory. The study adopted a descriptive research design with the target population comprising of Kenya Prison Staff. Primary data was obtained using self-administered questionnaires while secondary data was obtained using data collection sheet. Data was analysed using Statistical Package for Social Sciences (SPSS Version 23.0) which is the most recent version. Descriptive statistics such as frequencies, percentages were estimated for all the quantitative variables and information presented inform of tables. The qualitative data from the open-ended questions was analysed using conceptual content analysis and presented in prose. Inferential data analysis was done using multiple …

Orono S, Gitao C, Mpatswenumugambo J, Chepkwony M, Mutisya C, Okoth E, Bronsvoort M, Russell C, Nene V, Cook A. "Field validation of clinical and laboratory diagnosis of wildebeest associated malignant catarrhal fever in cattle." BMC Veterinary research . 2019;(doi.org/10.1186/s12917-019-1818-8).orono_et_al-2019-bmc_veterinary_research.pdf
Xu Y, Seward P, Gaye C, Lin L, Olago DO. "Groundwater in Sub-Saharan Africa." Hydrogeology Journal. 2019;27(3):815-822. AbstractWebsite

Sub-Saharan Africa (SSA; Fig. 1) refers to an area encompassing the countries in Africa that are fully, or partially, located south of the Sahara. The remaining African countries are generally referred to as belonging in North Africa. Although the socio-economic and hydrogeological conditions in SSA are diverse, they are sufficiently distinct (in general) from the conditions in North Africa to warrant being assessed separately—for example, high-yielding, high-storage, sedimentary aquifers are more common in North Africa than in SSA, while low-yielding, low-storage, basement aquifers are more widespread in SSA than in North Africa. The use of fossil groundwater is more typical in North Africa, while the use or renewable groundwater is more typical in SSA. Other hydrological characteristics associated with SSA include: groundwater resources that are generally under-utilized; lack of research and development that often prevents the optimal use of groundwater rather than over-development; and a heavy reliance by the rural and urban poor on shallow unconfined or semi-confined groundwater for potable water supplies, other domestic uses, and subsistence agriculture. Because of distinguishing characteristics such as these, there are good reasons for treating the hydrogeology of SSA as a whole, and separate from North Africa.

Bebora LC, Gathumbi PK, Muchemi GM, Gakuya FM, Manyibe TN, Kariuki EK, Ngatia TA, Maina EW. "Hematologic Values of Healthy and Sick Free-ranging Lesser Flamingos (Phoeniconaias minor) in Kenya." Journal of Wildlife Diseases. 2019;55(1):123-128.abstract.pdf
Nyariki TM, Gathumbi PK, Bebora LC, Muchemi GM, Ngatia TA. "Hematologic Values of Healthy and Sick Free-Ranging Lesser Flamingos (Phoeniconaias minor) in Kenya." Journal of Wildlife Diseases.. 2019;55(1):123-128.
Gitao, C.G., Orono, S, Cook, A. How to Diagnose Malignant Catarrhal fever and views from Pastoralists. Saarbrucken: Lap Lambert Academic Publishing; 2019.978-620-0-10122-8_coverpreview_2.pdf
Johnson MA, Garland CR, Jagoe K, Edwards R, Ndemere J, Weyant C, Patel A, Kithinji J, Wasirwa E, Nguyen T, Khoi DD, Kay E, Scott P, Nguyen R, Yagnaraman M, Mitchell J, Derby E, Chiang RA, Pennise D. "In-Home Emissions Performance of Cookstoves in Asia and Africa." Atmosphere. 2019;10(5):290. AbstractWebsite

Abstract
This paper presents results from eight field studies in Asia and Africa on the emissions performance of 16 stove/fuel combinations measured during normal cooking events in homes. Characterizing real-world emissions performance is important for understanding the climate and health implications of technologies being promoted as alternatives to displace baseline cooking stoves and fuels. Almost all of the stove interventions were measured to have substantial reductions in PM2.5 and CO emissions compared to their respective baseline technologies (reductions of 24–87% and 25–80%, for PM2.5 and CO emission rates, respectively), though comparison with performance guidance from the World Health Organization (WHO) and the International Organization for Standardization (ISO) suggests that further improvement for biomass stoves would help realize more health benefits. The emissions of LPG stoves were generally below the WHO interim PM2.5 emissions target (1.75 mg/min) though it was not clear how close they were to the most aspirational ISO (0.2 mg/min) or WHO (0.23 mg/min) targets as our limit of detection was 1.1 mg/min. Elemental and organic carbon emission factors and elemental-to-total carbon ratios (medians ranging from 0.11 to 0.42) were in line with previously reported field-based estimates for similar stove/fuel combinations. Two of the better performing forced draft stoves used with pellets—the Oorja (median ET/TC = 0.12) and Eco-Chula (median ET/TC = 0.42)—were at opposite ends of the range, indicating that important differences in combustion conditions can arise even between similar stove/fuel combinations. Field-based tests of stove performance also provide important feedback for laboratory test protocols. Comparison of these results to previously published water boiling test data from the laboratory reinforce the trend that stove performance is generally better during controlled laboratory conditions, with modified combustion efficiency (MCE) being consistently lower in the field for respective stove/fuel categories. New testing approaches, which operate stoves through a broader range of conditions, indicate potential for better MCE agreement than previous versions of water boiling tests. This improved agreement suggests that stove performance estimates from a new ISO laboratory testing protocol, including testing stoves across low, medium, and high firepower, may provide more representative estimates of real-world performance than previously used tests. More representative results from standardized laboratory testing should help push stove designs toward better real-world performance as well as provide a better indication of how the tested technologies will perform for the user. View Full-Text
Keywords: household energy; solid fuel; biomass; stove performance; emission factors; black carbon

M M, LZ M, J F, GM E, E R, R N, J T, DH M, Nyagol J, F W, AK B, M B, JG O. "Kaposi Sarcoma-Associated Herpesvirus Glycoprotein H Is Indispensable for Infection of Epithelial, Endothelial, and Fibroblast Cell Types." J Virol.. 2019;93(16).
Simonich CA, Doepker L, Ralph D, Williams JA, Dhar A, Yaffe Z, Gentles L, Small CT, Oliver B, Vigdorovich V, Mangala Prasad V, NNduati R. "Kappa chain maturation helps drive rapid development of an infant HIV-1 broadly neutralizing antibody lineage.". 2019.
Lockwood NM, Lypen K, Shalabi F, Kumar M, Ngugi E, Diener L, GW. H. "'Know that You are not Alone.' Influences of Social Support on Youth Newly Diagnosed with HIV in Kibera, Kenya: A Qualitative Study Informing Intervention Development." Int J Environ Res Public Health.. 2019; 4;(16(5):. pii: E775. doi: 10.3390/ijerph16050775.
Anthony Egeru, Oliver Wasonga, Gabiri G, MacOpiyo L, Mburu J, JGMM. "Land Cover and Soil Properties Influence on Forage Quantity in a Semiarid Region in East Africa." Applied and Environmental Soil Science. 2019;2019.
Guthua SW, Kamau MW, ABINYA N, Khainga S. "Management of Maxillofacial Osteosarcomas: A Kenyan experience (case series)." Annuals of African Surgery Journal. 2019.
M W, G P, GJ H, G C, A C, I G, S G, AM G, S LL, P L, K M. "Maternal characteristics and causes associated with refractory postpartum haemorrhage after vaginal birth: a secondary analysis of the WHO CHAMPION trial data." BJOG: An International Journal of Obstetrics & Gynaecology.. 2019;127(5):628-634. AbstractWebsite

Objective: To assess the maternal characteristics and causes associated with refractory postpartum haemorrhage (PPH).

Design: Secondary analysis of the WHO CHAMPION trial data.

Setting: Twenty-three hospitals in ten countries.

Population: Women from the CHAMPION trial who received uterotonics as first-line treatment of PPH.

Methods: We assessed the association between sociodemographic, pregnancy and childbirth factors and refractory PPH, and compared the causes of PPH between women with refractory PPH and women responsive to first-line PPH treatment.

Main outcome measures: Maternal characteristics; causes of PPH.

Results: Women with labour induced or augmented with uterotonics (adjusted odds ratio [aOR] 1.35; 95% CI 1.07-1.72), with episiotomy or tears requiring suturing (aOR 1.82; 95% CI 1.34-2.48) and who had babies with birthweights ≥3500 g (aOR 1.33; 95% CI 1.04-1.69) showed significantly higher odds of refractory PPH compared with the reference categories in the multivariate analysis adjusted by centre and trial arm. While atony was the sole PPH cause in 53.2% (116/218) of the women in the responsive PPH group, it accounted for only 31.5% (45/143) of the causes in the refractory PPH group. Conversely, tears were the sole cause in 12.8% (28/218) and 28% (40/143) of the responsive PPH and refractory PPH groups, respectively. Placental problems were the sole cause in 11 and 5.6% in the responsive and refractory PPH groups, respectively.

Conclusion: Women with refractory PPH showed a different pattern of maternal characteristics and PPH causes compared with those with first-line treatment responsive PPH.

Guthua SW, Kamau MW, NGANGA P. "Maxillary Alveolar cleft grafting in cleft lip and palate: Options of bone graft and soft tissue coverage." Kenya Dental Association Journal. 2019.
Bauza V, Madadi V, Ocharo RM, Nguyen TH, Guest JS. "Microbial source tracking using 16S rRNA amplicon sequencing identifies evidence of widespread contamination from young children’s feces in an urban slum of Nairobi, Kenya." Environmental science & technology. 2019;53(14):8271-8281. AbstractEnvironmental science &amp; technology

Description
Child exposure to fecal contamination remains common in low- and middle-income countries after sanitation interventions. Unsafe disposal of children’s feces may contribute to this continued exposure, but its relative importance to domestic fecal contamination is not well understood. To address this gap, we interviewed and collected environmental samples (drinking water, caregiver hands, child hands, surfaces, soil, open drainage ditches, standing water, streams) from 40 households in Kibera, an urban slum in Nairobi, Kenya. To track young children’s feces (<3 years old) separately from other human-associated fecal sources, we validated distance-based and Bayesian (SourceTracker) microbial source tracking methods using amplicon-based sequencing of the 16S rRNA gene. Contamination by young children’s feces could be identified and distinguished separately from older child/adult feces with high …

Serem EK, Abuom TO, Peter SG, Gakuya DW, Kirui GK, Mbuthia PG. "Microcardia Associated with Traumatic Reticulo Pericarditis (TRP) In an Adult Female Ayrshire Cow A Case Report." International Journal of Veterinary Science. 2019;8(2):73-78.
Osiro OA, Kariuki DK, Gathece LW. "The Minamata Convention on Mercury and its implications for management of dental caries in low‐and middle‐income countries." International Dental Journal. 2019:doi: 10.1111/idj.12461.
Lydia MS, Bulimo WD, Verani JR, Victor O, Ouma A, Kiplangat S, Opanda S, Imbuga M, Juma B, Godfrey B, Hunsperger E. "Molecular Characterization of Human Enteroviruses Detected in Children Under Five Years Old in Kenya 2009 - 2015." African Journal of Health Sciences. 2019;32(2):15-33. Abstract195711-article_text-494299-1-10-20200512.pdf195711-article_text-494299-1-10-20200512.pdf

INTRODUCTION
Human enterovirus (HEVs) infection is common, with an extensive array of clinical
displays ranging from asymptomatic to life-threatening. Presentation include nonspecific febrile
illness often accompanied by muscle pain, sore throat, abdominal discomfort, rash, headache,
encephalitis, aseptic meningitis and acute flaccid paralysis [2].
OBJECTIVES
The study objective was to investigate the natural selection and genetic variability of HEVs
and to identify HEV serotypes in circulation among children below 5 years old with diarrhea in
an informal settlement(Kibera) in Kenya.
METHODOLOGY
Specimens (n=628) from a prospective cohort study assessing the incidence and etiology of
diarrhea from 2009-2015 were analyzed. Enteric Taqman array cards (TAC) were used for initial
screening where two hundred and nine (78%) tested positive for HEVs.
Of these specimens, 72 (42%) had a cycle threshold (Ct) ≤30 and were tested by conventional
PCR targeting the 3’ regions of the viral protein 1 (VP1) gene. A total of 48 (67%) underwent
sequencing; 11 (23%) of which yielded nucleotide sequences. Phylogenetic analyses clustered
the Kenyan serotypes to HEVs groups C, B and A. Evaluation of the VP1 amino acid sequences
revealed numerous amino acid substitutions in relation to reference strains, which were confirmed
to be due to natural selection by negative or positive selection.
CONCLUSION
The Heterogeneous nature of stool samples is known to influence disparities in viral nucleic
acid yields. TAC detected 209 of which 171 (82%) were confirmed positive for HEVs by realtime
reverse transcription polymerase chain reaction (RRT-PCR), targeting the 5’ NTR regions.
Therefore, the results may not be a representative of all circulating HEVs in the study area. Since
this was a retrospective study of previously collected samples, it is possible that some HEVs strains
may have failed to amplify.

Gichuyia LN. "NAIROBI CITY MARKET: AN ELASTIC ARCHITECTURE AND URBAN DE- SIGN EXPERIENCE ACROSS TIME AND SPACE.". In: NAIROBI CITY MARKET: AN ELASTIC ARCHITECTURE AND URBAN DE- SIGN EXPERIENCE ACROSS TIME AND SPACE. Leuven, Belgium: Leuven University Press ; 2019.
Gakuya, F., Mwaura, F., Mwaniki, S.W, Muthama, J.M. "A New Frontier in Collaborative Approaches in Sustainable Open Spaces Delivery."; 2019.
Gichuyia LN, Madette E. "OCHA: THE EAST AFRICAN COUNTRYSIDE FORMS.". In: OCHA: THE EAST AFRICAN COUNTRYSIDE FORMS. Rotterdam, Netherlands: OMA/AMO Press; 2019.
Omondi F, Mostarda L, Shah P, Ever E, Gemikonakli O. "On the performance, availability and energy consumption modelling of clustered IoT systems." Springer Link Computing. 2019;101(12):1935-1970. Abstract

Wireless sensor networks (WSNs) form a large part of the ecosystem of the Internet of Things (IoT), hence they have numerous application domains with varying performance and availability requirements. Limited resources that include processing capability, queue capacity, and available energy in addition to frequent node and link failures degrade the performance and availability of these networks. In an attempt to efficiently utilise the limited resources and to maintain the reliable network with efficient data transmission; it is common to select a clustering approach, where a cluster head is selected among the diverse IoT devices. This study presents the stochastic performance as well as the energy evaluation model for WSNs that have both node and link failures. The model developed considers an integrated performance and availability approach. Various duty cycling schemes within the medium-access control of the WSNs are also considered to incorporate the impact of sleeping/idle states that are presented using analytical modeling. The results presented using the proposed analytical models show the effects of factors such as failures, various queue capacities and system scalability. The analytical results presented are in very good agreement with simulation results and also present an important fact that the proposed models are very useful for identification of thresholds between WSN system characteristics.

NDUNG’U GM, Odhiambo WA, Guthua SW, Onyango JF. "Paediatric Craniomaxillofacial Trauma at the Kenyatta National Referral and Teaching Hospital in Nairobi, Kenya: A 6-months study of Occurrence Pattern." African Journal of Oral Health Sciences. 2019;2 (6):14-20.
Omani R, Gitao C, Gachohi J, Gathumbi P, Bwihangane A, Khalif A, Chemweno V. "Peste Des Petits Ruminants (PPR) in Dromedary Camels and Small Ruminants in Mandera and Wajir Counties of Kenya." Advances in Virology . 2019;(doi.org/10.1155/2019/4028720).
Omani RN, Gitao CG, Gachohi J, Gathumbi PK, Bwihane BA, Abbey K, Chemwono VJ. "Peste des petits ruminants in dromedary camels and small ruminants in Mandera and Wajir Counties of Kenya." Advances Virology. 2019;Volume 2019 Article ID 4028720 6 pages(https://doi.org/10.1155/2019/4028720).
D P, ZP Q, K L, MK K, GN G, Odawa FX, A O, O K, PK K, Kosgei RJ, AB K, PM N, O O. "Policy Brief - Increasing Caesarean Section rates among low risk women after introduction of free maternity services in a Kenyan National Referral Hospital." Journal of Obstetrics and Gynaecology of East & Central Africa. 2019;30(2):52-53.Website
Chemweno V, Gitao C, Gachohi J, Soi R, Ndungu E, Khalif A. "PPR in Camels: Sero-Prevalence and Socio-Economics." International Journal of Veterinary Science. 2019;8(2):84-88.vivian_paper.pdf
XuEmail Y, Seward P, Gaye C, Lin L, Olago DO. "Preface: Groundwater in Sub-Saharan Africa." Hydrogeology Journal. 2019;27(3):815-822. Abstractxu2019_article_prefacegroundwaterinsub-sahara1.pdfWebsite

Introduction
Sub-Saharan Africa (SSA; Fig. 1) refers to an area encompassing the countries in Africa that are fully, or partially, located south of the Sahara. The remaining African countries are generally referred to as belonging in North Africa. Although the socio-economic and hydrogeological conditions in SSA are diverse, they are sufficiently distinct (in general) from the conditions in North Africa to warrant being assessed separately—for example, high-yielding, high-storage, sedimentary aquifers are more common in North Africa than in SSA, while low-yielding, low-storage, basement aquifers are more widespread in SSA than in North Africa. The use of fossil groundwater is more typical in North Africa, while the use or renewable groundwater is more typical in SSA. Other hydrological characteristics associated with SSA include: groundwater resources that are generally under-utilized; lack of research and development that often prevents the optimal use of groundwater rather than over-development; and a heavy reliance by the rural and urban poor on shallow unconfined or semi-confined groundwater for potable water supplies, other domestic uses, and subsistence agriculture. Because of distinguishing characteristics such as these, there are good reasons for treating the hydrogeology of SSA as a whole, and separate from North Africa.

Ntampaka P, Nyaga PN, Gathumbi JK, Tukei M. "Rabies serosurvey of domestic dogs in Kigali City, Rwanda." Journal of Veterinary Medicine and Animal Health. 2019;11:64-72.
Cyr JL, Gawriluk TR, Kimani JM, Rada B, Watford WT, Kiama SG, Seifert AW, Ezen VO. "Regeneration-Competent and -Incompetent Murids Differ in Neutrophil Quantity and Function.". 2019.
Cyr JL, Gawriluk TR, Kimani JM, Rada B, Watford WT, Kiama SG, Seifert AW, Ezenwa VO. "Regeneration-competent and-incompetent murids differ in neutrophil quantity and function.". 2019.
Gikunju M, Nyamato-Kwenda R, Kwanya T. "A review of citizen librarianship in academic libraries in Kenya.". In: Digital Technologies for Information and Knowledge Management. Nairobi: Technical University of Kenya; 2019.
Chimoita EL, Onyango CM, Gweyi-Onyango JP, Kimenju JW. "Socio-economic and Institutional Factors Influencing Uptake of Improved Sorghum Technologies in Embu, Kenya." East African Agricultural and Forestry Journal. 2019:1-11.
Chimoita EL, Onyango CM, Gweyi-Onyango JP, Kimenju JW. "Socioeconomic and Institutional Factors Influencing Uptake of Improved Sorghum Technologies in Embu, Kenya." East African Agricultural and Forestry Journal. 2019;2(1):DOI: 10.1080/00128325.2019.1597568.
G. W, N KC, MW O, H.G. R. "Status and process analysis of Koche, a traditional pastoral meat product in Kenya." Pastoralism: Research, Policy and Practice. 2019;9(6):1-7.
Omole RA, Moshi MJ, Heydenreich M, Malebo HM, Gathirwa JW, Ochieng SA, Omosa LK, Midiwo JO. "Two lignans derivatives and two fusicoccane diterpenoids from the whole plant of Hypoestes verticillaris (LF) Sol. Ex roem. & schult." Phytochemistry Letters. 2019;30:194-200. Abstract

Bioassay-guided screening of Hypoestes verticillaris whole plant CH2Cl2:MeOH (1:1) extract for anti-plasmodial activity yielded four new compounds: two lignans 2, 6-dimethoxysavinin (1), 2,6-dimethoxy-(7E)-7,8-dehydroheliobuphthalmin (2); and two fusicoccane diterpenoids: 11(12)-epoxyhypoestenone (3) and 3(11)-epoxyhypoestenone (4). The chemical structures were determined using various spectroscopic techniques: UV–vis, IR, CD, 1D, 2D and MS. Two fractions (RAO-43B and RAO-43D) and the isolated compounds were tested for activity against CQ susceptible (D6) and resistant (W2) Plasmodium falciparum parasite strains, in vitro and the IC50 values determined. While the whole extract and some resultant fractions displayed moderate activity, the isolated compounds exhibited mild anti-plasmodial activity against the both strains ranging from IC50 value of 328 μM in 1 to 93 μM in 3 against W2 strain.

Ru BL, Capdevielle-Dulac C, Njaku M, Assefa Y, Chipabika G, George Ong’Amo, Jérôme Barbut GKJ. "Updated phylogenetic and systematics of the Acrapex albivena Hampson, 1910 and A. stygiata (Hampson, 1910) species groups (Lepidoptera, Noctuidae, Noctuinae, Apameini, Sesamiina), with the description of nine new species from the Afrotropics." Annales de la Société entomologique de France (NS). 2019;55(3):219-248.
D P, ZP Q, K L, MK K, GN G, Odawa FX, A O, O K, PK K, Kosgei RJ, AB K, PM N, O O. "Use of the Robson Classification to compare Caesarean Section patterns at the Kenyatta National Hospital after and before free Maternity Services in Kenya." Journal of Obstetrics and Gynaecology of East & Central Africa. 2019;30(2):46-51.Website
Ogeng’o JA, Mpekethu N, Gichangi P, Olabu B, Odula P, Munguti J, Misiani M. "VARIANT ANATOMY OF THE TESTICULAR ARTERY AMONG BLACK KENYANS." Anatomy Journal of Africa . 2019;8(1):1358-1367. Abstractvariant_anatomy_of_the_testicular_artery_among.pdf

Variant anatomy of the testicular artery is important for safe surgery in the retroperioneal area, and
accurate diagnosis of testicular and renal disease. The pattern of origin, number, course and branching
display ethnic and geographical variations. Data from black African populations and especially Eastern
Africa is scarce. The objective of this study was, therefore, to describe the topography of the intraabdominal
part of testicular artery in a sample of the Kenyan population. This was a descriptive crosssectional
study on one hundred (100) testicular arteries at the Department of Human Anatomy, University
of Nairobi. The samples were obtained from autopsy cases and cadaveric specimens. Standard midline
abdominal incisions were made, flaps of the anterior abdominal wall reflected and the intestines,
mesentery and pariental peritoneum retracted systematically to expose the testicular arteries. Their site
and level of origin, number, course and branching were examined. Macrographs of representative
variations were taken using a high resolution digital camera. The results were analysed using SPSS
version 21, and are presented using macrographs and frequency tables. Thirty three (33%) of the arteries
displayed a variant anatomy, with regard to their site of origin (8%), number (4%), course (14%) and
branching pattern (7%). Among the 14 cases of aberrant course, five (5%) arched over the left renal
vein, eight (8%) were retrocaval and one (1%) had a retroureteric course. Seven (7%) bifurcated within
the abdomen. The level of origin along the aorta varied from 1 centimetre above the renal arteries to 5.5
centimetres below them while the vertebral level of origin ranged from T12 to L4. This shows that the
testicular artery among Kenyans displays a high prevalence of variant anatomy characterized by origin
from the accessory renal artery, high level of aortic origin, duplication, retrocaval course and
intraabdominal; division. Preopertaive evaluation of renal and gonadal vasculature is recommended to
minimize misdiagnosis and inadvertent injury retroperitoneal surgery.

JK Omari, Mworia JK, Gichuki N, Mligo C. "Woody Species Composition in Upper Tana River Floodplain of Kenya: Potential Effects of Change in Flood Regimes." Journal of sustainability, environment and peace . 2019;1:91-97.
GATARI MJ. "First WHO Global Conference on Air Pollution and Health: A Brief Report." Clean Air Journal. 2019. AbstractWebsite

The subject conference (documented in www. who. int) was organized by WHO in collaboration with WMO, CCAC, UNFCC, UNECE, The World Bank, UN-DESA and EU-DEVCO in Geneva, Switzerland from 30 October to 01 November 2018. The conference …

GATARI MJ, Kinney PL, Yan B, Sclar E,... "High airborne black carbon concentrations measured near roadways in Nairobi, Kenya." … Research Part D …. 2019. AbstractWebsite

Airborne black carbon (BC) particles have serious implications for human health and climate change and thus represent a prime target for mitigation policies. The sources of BC include vehicles burning diesel fuel, which are common in urban areas in low-income countries. The …

Gitau J, GATARI MJ, Pant HJ. "Investigation of flow dynamics of porous clinkers in a ball mill using technitium-99m as a radiotracer." Applied Radiation and Isotopes. 2019. AbstractWebsite

A radiotracer investigation was carried out in a ball mill of a cement plant in Kenya. Residence time distribution (RTD) of raw feed to the mill was measured using Technetium-99m adsorbed on the clinkers as a radiotracer. From the measured RTDs, solid holdup and …

2018
Gitao, C.G. "PhD supervision at University of Nairobi.". In: Carta Supervision workshop. Johannesburg, South Africa; 2018.
Mwangi N, Minnies D, Parsley S, Patel D, Gichuhi S, Muthami L, Moorman C, Macleod D, Bascaran C, Foster A. "Developing open online learning resources: Lessons from a short course on the control of blindness from diabetic retinopathy.". In: College of Ophthalmologists in Eastern Central & Southern Africa (COECSA). Addis Ababa; 2018. Abstract

Background: A need identified during another study prompted the development of the open online course on control of blindness from diabetic retinopathy. In our technological age, potential for learning online can provide a unique opportunity to develop context-specific content for local relevance. We report on the lessons learnt in the development of this short online course for an international audience of diverse eye care practitioners.

Methods: We developed this online short course through a formal planning process facilitated by UNESCO. The participants included eye health educators, learning designers, and content experts. The course curriculum was informed by learning from an ongoing doctorate program, as well as by clinical, public health and educational experience.

Results: Lessons learnt include:
1. Identifying the need and content – Learning and research from a doctorate research program can inform content development.
2. Identifying the relevance – the content needs to be customized for the target audience and local context.
3. Developing the learning design – promoting digital teaching skills and co-creation of content are valuable entry points.
4. Accommodating appropriate peer review and mentorship may enhance learning and quality assurance.
5. Resource planning activities need to be documented as a learning point.
6. There are significant costs in course development, such as time spent in content development, and ongoing maintenance eg maintaining the online platform.
7. Sources of quality open access resources in eye care are limited.

Conclusion: Content development is a unique learning experience, and it is essential to develop and support context specific learning resources. Open educational practice supports a collaborative process that enhances relevance and quality of training. The online format emphasizes the importance of learning design requirements to bridge the transactional distance between the participant and the educator.

Osiro OA, Kariuki DK, Gathece LW. "Composition, Particle Size, Setting Time of Clinker and Geopolymer Cements.". In: IADR. London, UK; 2018.
Mwihia EW, Lyche JL, Mbuthia PG, Gathumbi JK, Maina J, Ivanova L, Uhlig S, Mulei IR, Eriksen GS. "Co-occurrence of multiple mycotoxins in fish feed in Kenya.". In: ASM 2018 Scientific Programme. Leisure Lodge Resort, Mombasa, Kenya; 2018.
Ayah R, Gitau S, Rogge M, Mugasia D, Hoyle W, Ogot M. "Creating High Value, High Impact Products from Recycled Plastic: Case Study, Building Digital Microscopes for Malaria Diagnosis. .". In: 1st Annual Architecture & Engineering Conference. Nairobi, Kenya; 2018.
BIRIR J, Gatari MJ, RAJAGOPAL P, Mwea SK, MUIA ML. "Interaction of ultrasonic waves with defects.". In: NDE2018. Mumbai, India; 2018.
Marangu D, Pillay K, Banderker E, Gray D, Vanker A, Zampoli M. "Exogenous lipoid pneumonia: an important cause of interstitial lung disease in infants." Respirol Case Rep. 2018;6(7):e00356. Abstract

Exogenous lipoid pneumonia (ELP), an important cause of interstitial lung disease, often goes unrecognized. We conducted a retrospective study of children with histologically confirmed ELP at Red Cross Children's Hospital, South Africa. Twelve children of Zimbabwean heritage aged 2.1-10.8 months were identified between 2012 and 2017. Repeated oral administration of plant-based oil for cultural reasons was reported by 10 of 11 caregivers. Cough (12/12), tachypnoea (11/12), hypoxia (9/12), and diffuse alveolar infiltrates on chest radiography (12/12) were common at presentation. Chest computed tomography revealed ground-glass opacification with lower zone predominance (9/9) and interlobular septal thickening (8/9). Bronchoalveolar lavage specimens appeared cloudy/milky, with abundant lipid-laden macrophages and extracellular lipid on Oil-Red-O staining (12/12), with polymicrobial (6/12) and Mycobacterium abscessus (2/12) co-infection. Antibiotics, systemic corticosteroids, and therapeutic lavage were interventions in all eight and five patients, respectively. Clinicians should consider ELP in children with non-resolving pneumonia in settings with similar practices.

Nangia V, Jonas JB, George R, Lingam V, Ellwein L, Cicinelli MV, Das A, Flaxman SR, Keeffe JE, Kempen JH, Leasher J, Limburg H, Naidoo K, Pesudovs K, Resnikoff S, Silvester AJ, Tahhan N, Taylor HR, Wong TY, Bourne RRA. "Prevalence and causes of blindness and vision impairment: magnitude, temporal trends and projections in South and Central Asia." Br J Ophthalmol. 2018. AbstractWebsite

BACKGROUND:To assess prevalence and causes of vision loss in Central and South Asia.

METHODS: A systematic review of medical literature assessed the prevalence of blindness (presenting visual acuity<3/60 in the better eye), moderate and severe vision impairment (MSVI; presenting visual acuity <6/18 but ≥3/60) and mild vision impairment (MVI; presenting visual acuity <6/12 and ≥6/18) in Central and South Asia for 1990, 2010, 2015 and 2020.

RESULTS: In Central and South Asia combined, age-standardised prevalences of blindness, MSVI and MVI in 2015 were for men and women aged 50+years, 3.72% (80% uncertainty interval (UI): 1.39-6.75) and 4.00% (80% UI: 1.41-7.39), 16.33% (80% UI: 8.55-25.47) and 17.65% (80% UI: 9.00-27.62), 11.70% (80% UI: 4.70-20.32) and 12.25% (80% UI:4.86-21.30), respectively, with a significant decrease in the study period for both gender. In South Asia in 2015, 11.76 million individuals (32.65% of the global blindness figure) were blind and 61.19 million individuals (28.3% of the global total) had MSVI. From 1990 to 2015, cataract (accounting for 36.58% of all cases with blindness in 2015) was the most common cause of blindness, followed by undercorrected refractive error (36.43%), glaucoma (5.81%), age-related macular degeneration (2.44%), corneal diseases (2.43%), diabetic retinopathy (0.16%) and trachoma (0.04%). For MSVI in South Asia 2015, most common causes were undercorrected refractive error (accounting for 66.39% of all cases with MSVI), followed by cataract (23.62%), age-related macular degeneration (1.31%) and glaucoma (1.09%).

CONCLUSIONS: One-third of the global blind resided in South Asia in 2015, although the age-standardised prevalence of blindness and MSVI decreased significantly between 1990 and 2015.

Mwangi N, Gachago M, Gichangi M, Gichuhi S, Githeko K, Jalango A, Karimurio J, Kibachio J, Muthami L, Ngugi N, Nduri C, Nyaga P, Nyamori J, Zindamoyen ANM, Bascaran C, Foster A. "Adapting clinical practice guidelines for diabetic retinopathy in Kenya: process and outputs." Implement Sci. 2018;13(1):81. Abstract

The use of clinical practice guidelines envisages augmenting quality and best practice in clinical outcomes. Generic guidelines that are not adapted for local use often fail to produce these outcomes. Adaptation is a systematic and rigorous process that should maintain the quality and validity of the guideline, while making it more usable by the targeted users. Diverse skills are required for the task of adaptation. Although adapting a guideline is not a guarantee that it will be implemented, adaptation may improve acceptance and adherence to its recommendations.

Mwangi N, Ng'ang'a M, Gakuo E, Gichuhi S, Macleod D, Moorman C, Muthami L, Tum P, Jalango A, Githeko K, Gichangi M, Kibachio J, Bascaran C, Foster A. "Effectiveness of peer support to increase uptake of retinal examination for diabetic retinopathy: study protocol for the DURE pragmatic cluster randomized clinical trial in Kirinyaga, Kenya." BMC Public Health. 2018;18(1):871. Abstract

All patients with diabetes are at risk of developing diabetic retinopathy (DR), a progressive and potentially blinding condition. Early treatment of DR prevents visual impairment and blindness. The natural history of DR is that it is asymptomatic until the advanced stages, thus annual retinal examination is recommended for early detection. Previous studies show that the uptake of regular retinal examination among people living with diabetes (PLWD) is low. In the Uptake of Retinal Examination in Diabetes (DURE) study, we will investigate the effectiveness of a complex intervention delivered within diabetes support groups to increase uptake of retinal examination.

Gitobu CM, Gichangi PB, Mwanda WO. "The effect of Kenya's free maternal health care policy on the utilization of health facility delivery services and maternal and neonatal mortality in public health facilities." BMC Pregnancy Childbirth. 2018;18(1):77. Abstract

Kenya abolished delivery fees in all public health facilities through a presidential directive effective on June 1, 2013 with an aim of promoting health facility delivery service utilization and reducing pregnancy-related mortality in the country. This paper aims to provide a brief overview of this policy's effect on health facility delivery service utilization and maternal mortality ratio and neonatal mortality rate in Kenyan public health facilities.

Do DV, Gichuhi S, Vedula SS, Hawkins BS. "Surgery for postvitrectomy cataract." Cochrane Database Syst Rev. 2018;1:CD006366. AbstractWebsite

BACKGROUND:
Cataract formation or acceleration can occur after intraocular surgery, especially following vitrectomy, a surgical technique for removing the vitreous that is used in the treatment of many disorders that affect the posterior segment of the eye. The underlying problem that led to vitrectomy may limit the benefit from removal of the cataractous lens.

OBJECTIVES:
To evaluate the effectiveness and safety of surgery versus no surgery for postvitrectomy cataract with respect to visual acuity, quality of life, and other outcomes.

SEARCH METHODS:
We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (which contains the Cochrane Eyes and Vision Trials Register) (2017, Issue 5), MEDLINE Ovid (1946 to 17 May 2017), Embase.com (1947 to 17 May 2017), PubMed (1946 to 17 May 2017), Latin American and Caribbean Health Sciences Literature database (LILACS) (January 1982 to 17 May 2017), the metaRegister of Controlled Trials (mRCT) (www.controlled-trials.com); last searched May 2013, ClinicalTrials.gov (www.clinicaltrials.gov); searched 17 May 2017, and the World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP) (www.who.int/ictrp/search/en); searched 17 May 2017. We did not use any date or language restrictions in the electronic searches for trials.

SELECTION CRITERIA:
We planned to include randomized controlled trials (RCTs) and quasi-RCTs that had compared surgery versus no surgery to remove the lens from eyes of adults in which cataracts had developed following vitrectomy.

DATA COLLECTION AND ANALYSIS:
Two review authors independently screened the search results according to the standard methodological procedures expected by Cochrane.

MAIN RESULTS:
We found no RCTs or quasi-RCTs that had compared surgery versus no surgery to remove the lens from eyes of adults in which cataracts had developed following vitrectomy.

AUTHORS' CONCLUSIONS:
There is no evidence from RCTs or quasi-RCTs on which to base clinical recommendations for surgery for postvitrectomy cataract. There is a clear need for RCTs to address this evidence gap. Such trials should stratify participants by their age, the retinal disorder leading to vitrectomy, and the status of the underlying disease process in the contralateral eye. Outcomes assessed in such trials may include changes (both gains and losses) of visual acuity, quality of life, and adverse events such as posterior capsular rupture and retinal detachment. Both short-term (six-month) and long-term (one- or two-year) outcomes should be examined.
Update of Surgery for post-vitrectomy cataract. [Cochrane Database Syst Rev. 2013]

Emily N Kitivo, GH Nyamasyo JKM. "Agroecosytem disservices and service providers." South Eastern Kenya University; 2018.

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