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2018
Gaitho D, Kumar M, Wamalwa D, Farquhar C, Wambua GN, R. N. "Understanding mental health difficulties and associated psychosocial outcomes in adolescents in the HIV clinic at Kenyatta National Hospital, Kenya." Ann Gen Psychiatry. 2018;10;(17:):29.
Ooko JO, Onyatta JO, Yusuf AO, Guto PM. "Use of Accelerated Tests to Estimate Rate of Corrosion of Roofing Sheets." International Journal of Sciences: Basic and Applied Research. 2018;37(3):1-8.
Sila JM, Guto PM, Michira IN, Mwaura FB. "Voltammetric Determination of Penicillin G in Sodium Dodecyl Sulfate/Acetet Buffer Media on Glassy carbon Electrode." international journal of Sciences: Basic and Applied Research (IJSBAR). 2018;42(4):144-155.
Foster C, Graham M, Mann L, Waema T, Friederici N. "Who controls the digital? Value chains and the challenges of connectivity for East African firms." Economic Geography. 2018;94(1):68-86. AbstractFull text link

In recent years, Internet connectivity has greatly improved across the African continent. This article examines the consequences that this shift has had for East African firms that are part of global value chains (GVCs). Prior work yielded contradictory expectations: firms might benefit from connectivity through increased efficiencies and improved access to markets, although they might also be further marginalized through increasing control of lead firms. Drawing on extensive qualitative research in Kenya and Rwanda,including 264 interviews, we examine 3 sectors (tea, tourism, and business process outsourcing) exploring overarching, cross-cutting themes. The findings support more pessimistic expectations: small African producers are only thinly digitally integrated in GVCs. Moreover, shifting modes of value chain governance, supported by lead firms and facilitated by digital information platforms and data standards are leading to new challenges for firms looking to digitally integrate. Nevertheless, we also find examples in these sectors of opportunities where small firms are able to cater to emerging niche customers, and local or regional markets. Overall, the study shows that improving connectivity does not inherently benefit African firms in GVCs without support for complementary capacity and competitive advantages.

Kang’ethe EK, H Korhonen, KA Marimba, G Nduhiu, JK Mungatu, Okoth SA, V Joutsjoki, LW Wamae, Shalo P. "肯尼亚地区对玉米中霉菌毒素引起的健康风险的管理和降低." Food Quality and Safety. 2018;1(4):268-274.
Pope FD, Gatari M, Ng'ang'a D,... "Airborne particulate matter monitoring in Kenya using calibrated low cost sensors [discussion paper]." Atmospheric …. 2018. AbstractWebsite

East African countries face an increasing threat from poor air quality, stemming from rapid urbanisation, population growth and a steep rise in fuel use and motorization rates. With few air quality monitoring systems available, this study provides the much needed high temporal …

Blake R, Pope F, Gatari M. "Airborne particulate matter monitoring in Nairobi, Kenya using calibrated low cost sensors." EGU General Assembly …. 2018. AbstractWebsite

This study investigated the use of low cost optical particle counters (OPCs) to measure particulate matter (PM) pollution in Nairobi, Kenya, between February and March 2017. Measurements were performed in three locations, an urban background and urban roadside …

Maina EG, Gachanja AN, GATARI MJ, Price H. "Demonstrating PM2.5 and road-side dust pollution by heavy metals along Thika superhighway in Kenya, sub-Saharan Africa." … monitoring and assessment. 2018. AbstractWebsite

This study assessed the level of heavy metal in roadside dust and PM 2.5 mass concentrations along Thika superhighway in Kenya. Thika superhighway is one of the busiest roads in Kenya, linking Thika town with Nairobi. Triplicate road dust samples …

2017
Gureya D, Barreto J. "Profiling for Asymmetric NUMA Systems.". In: 11th EuroSys Doctoral Workshop (EuroDW'17). Belgrade, Serbia; 2017. Abstract

n/a

Karuga SW, GATARI MJ, Kelder EM, Marijnissen JCM. "Solid-state electrolytes for lithium ion batteries: Application of Electrospray technique.". In: European Aerosol Conference. Zurich, Switzerland; 2017.
Kirui G, Gakuya DW, Abuom TO. "Challenges in food animal practice in the urban areas- Nairobi City and its environs.". In: The Kenya Veterinary Association, Commonwealth Veterinary Association and university Nairobi, Faculty of Veterianry Medicine Joint Scientific Conference. Safari Park Hotel, Nairobi, Kenya; 2017.
Gichuhi S, Kabiru J, Zindamoyen AM'bongo, Rono H, Ollando E, Wachira J, Munene R, Onyuma T, Sagoo MS, Macleod D, Weiss HA, Burton MJ. "Delay along the care-seeking journey of patients with ocular surface squamous neoplasia in Kenya." BMC Health Serv Res. 2017;17(1):485. AbstractWebsite

BACKGROUND:

In Africa, accessing eye health services is a major challenge. Ocular surface squamous neoplasia (OSSN) is a substantial ocular health problem in Africa related to solar UV light exposure and HIV infection among other risk factors. The disease causes visual loss and even death in advanced cases. This study was conducted to assess referral pathway and treatment delay for patients with OSSN in Kenya.
METHODS:

Adults with conjunctival lesions presenting to four eye centres were asked about their occupations, when they noticed the growth, health facilities visited in seeking care, cost of consultation, surgery, medicines and histopathology and dates at each step. The time-to-presentation was divided into quartiles and correlates analysed using ordinal logistic regression.
RESULTS:

We evaluated 158 first-time presenters with OSSN. Most were women (102 [65%]), living with HIV (78/110 tested [71%]), with low to medium income (127 [80%]). Most of the HIV patients (49/78 [63%]) were in antiretroviral care programs. About half (88/158, [56%]) presented directly to the study centres while the rest were referred. Indirect presenters sought care earlier than direct presenters (median 2.0 months vs 5.5 months) and travelled a shorter distance to the first health facility (median 20 km vs 30 km) but had surgery later (median 12.5 months vs 5.5 months). Visits beyond the first health facility for indirect presenters markedly increased delay (median 7.3, 29.0, 37.9, and 32.0 months for 1-4 facilities, respectively). Delay was associated with number of health facilities visited (adjusted ordered OR = 9.12; 95%CI 2.83-29.4, p < 0.001) and being female (adjusted ordered OR = 2.42; 95%CI 1.32-4.44, p = 0.004). At the time of presentation at the study centres for surgery the median tumour diameter in both directly and indirectly presenting patients was 6 mm (p = 0.52) and the histological spectrum of OSSN was similar between the groups (p = 0.87).
CONCLUSIONS:

Referral delays definitive treatment for OSSN. Women were more likely to experience delay. Despite regular contact with the health system for those with known HIV infection, delays occurred. Early detection and referral of OSSN in the HIV service might reduce delays, but reassuringly delay did not give rise to a larger proportion with more advanced grade of OSSN.

Nyombayire J, Anzala O, Gazzard B, Karita E, Bergin P, Hayes P, Kopycinski J, Omosa-Manyonyi G, Jackson A, Bizimana J, Farah B, Sayeed E, Parks CL, Inoue M, Hironaka T, Hara H, Shu T, Matano T, Dally L, Barin B, Park H, Gilmour J, Lombardo A, Excler J-L, Fast P, Laufer DS, Cox JH. "First-in-Human Evaluation of the Safety and Immunogenicity of an Intranasally Administered Replication-Competent Sendai Virus-Vectored HIV Type 1 Gag Vaccine: Induction of Potent T-Cell or Antibody Responses in Prime-Boost Regimens." J. Infect. Dis.. 2017;215(1):95-104. Abstract

 We report the first-in-human safety and immunogenicity assessment of a prototype intranasally administered, replication-competent Sendai virus (SeV)-vectored, human immunodeficiency virus type 1 (HIV-1) vaccine.

Newman LP, Njoroge A, Magaret A, Chohan BH, Gitomea VW, Wald A, Gorstein J, Overbaugh J, Dalton Wamalwa, Maleche-Obimbo E, Ruth Nduati, Farquhar C. "Sustained Responses to Measles Revaccination at 24 Months in HIV-Infected Children on Antiretroviral Therapy in Kenya." Pediatr. Infect. Dis. J.. 2017. Abstract

There are limited data on whether HIV-infected children in resource-limited countries who are receiving antiretroviral therapy (ART) are able to produce sustained, protective levels of measles antibody after multiple measles vaccinations.

Goyette MS, Wilson KS, Deya R, Masese LN, Shafi J, Richardson BA, Mandaliya K, Jaoko W, McClelland SR. "Brief Report: Association Between Menopause and Unprotected Sex in High-Risk HIV-Positive Women in Mombasa, Kenya." J. Acquir. Immune Defic. Syndr.. 2017;74(5):488-492. Abstract

Many HIV-positive women now live well beyond menopause. Postmenopausal women are no longer at risk for pregnancy, and some studies suggest that they may use condoms less often than premenopausal women. This study tests the hypothesis that, in HIV-positive women who report trading sex for cash or in-kind payment, unprotected sex is more common at postmenopausal visits compared with premenopausal visits.

Ronen K, Dingens AS, Graham SM, Jaoko W, Mandaliya K, McClelland SR, Overbaugh J. "Comprehensive Characterization of Humoral Correlates of Human Immunodeficiency Virus 1 Superinfection Acquisition in High-risk Kenyan Women." EBioMedicine. 2017;18:216-224. Abstract

HIV-1 superinfection, in which an infected individual acquires a second HIV-1 infection from a different partner, is one of the only settings in which HIV acquisition occurs in the context of a pre-existing immune response to natural HIV infection. There is evidence that initial infection provides some protection from superinfection, particularly after 6months of initial infection, when development of broad immunity occurs. Comparison of the immune response of superinfected individuals at the time of superinfection acquisition to that of individuals who remain singly infected despite continued exposure can shed light on immune correlates of HIV acquisition to inform prophylactic vaccine design. We evaluated a panel of humoral immune responses in the largest published group of superinfected individuals (n=21), compared to a set of 3:1 matched singly infected controls from the same cohort. The immune functions studied included plasma neutralization, plasma and cervical antibody-dependent cellular cytotoxicity, and plasma IgG and IgA binding to a panel of 18 envelope antigens, including correlates of HIV acquisition in the RV144 vaccine trial, IgG binding to V1V2 and IgA binding to gp140. Association between each immune function and HIV superinfection was evaluated using conditional logistic regression. No significant associations were detected between any of the immune functions and superinfection acquisition. This study constitutes the most comprehensive and detailed characterization of multiple immune correlates of superinfection to date. The results suggest that immune responses not commonly measured in current HIV studies may be important in protection from HIV infection, and these or a more robust humoral response than that seen in naturally infected women may be needed for a protective vaccine.

Genga EK, Oyoo O, Espinoza LR, Adebajo A. "Africa Journal of Rheumatology: enhancing the visibility of rheumatology in Africa.". 2017. Abstractajr_enhancing_the_visibility_of_rheumatology_in_africa_2017-clinical_rheumatology.pdf

Africa Journal of Rheumatology: enhancing the visibility
of rheumatology in Africa
Eugene K. Genga1,2 & Omondi Oyoo1,2 & Luis R. Espinoza3 & Adewale Adebajo4
Received: 5 July 2017 /Accepted: 10 July 2017
# International League of Associations for Rheumatology (ILAR) 2017
Clinical Rheumatology welcomes the African Journal of
Rheumatology as an important development for the furtherance
of rheumatological scholarship and education on the
African continent and for rheumatology research in
Africans. It is hoped that this development will in turn raise
the profile of rheumatological conditions in Africa and among
Africans. In particular, it is hoped that this will lead to the
much needed collection of African musculoskeletal epidemiological
and health services data, assist in the training of
African rheumatologists, help to open up African rheumatology
to the global rheumatology community, and ultimately
improve the quality of care for myriads of Africans with rheumatic
disorders.
The current population of Africa is 1,241,858,354
which is equivalent to 16.36% of the total world population
based on the latest United Nations estimates [1].
There are many challenges facing Africa including limited
financial resources, misuse of finances, malnutrition, poor
water, and sanitation among others. Despite these many
challenges faced in Africa, in recent times, the continent
has undergone rapid economic growth and development.
The available healthcare resources are overburdened by
the high burden of communicable diseases and the rising
prevalence of non-communicable diseases. Rheumatic
diseases are therefore not considered a high priority by
the various African governments. Part of the reason for
this is due to the limited epidemiological data on rheumatic
diseases and their burden in Africa. Scientific
journals play a central role in the dissemination of research
results which will ultimately impact on policy
change. Horton et al. [2] noted that researchers and policy
makers in developing countries believe that the main way
to solve problems of developing countries is by using
information from Western research rather than using local
data to solve regional problems. He, however, noted that
in Africa “there is already a well-developed local information
culture that needs support, not swamping,” noting,
moreover, the lack of African journals in MEDLINE [2].
Researchers in Africa and the developing world require
access not only as readers but also as authors: for them
to feel part of the global science community, they need
not only to obtain information but also to be able to contribute
to it and take part in the global discourse. The
continent’s resources are prioritized towards infectious
diseases like HIV and malaria over the now increasing
non-communicable diseases. Data on rheumatic diseases
in Africa has been limited partly due to lack of infrastructure
thus under diagnosis but also due to low scholarly
output. Thus, the Africa Journal of Rheumatology was
born. Since its inception 5 years ago, it has provided an
uninterrupted forum through which medical practitioners
and scientists from Africa and beyond can publish their
rheumatology research. It has become a rich source of
information about rheumatic disorders in the continent
and a timely addition to our worldwide rheumatology
community [3]. The journal has published various research
articles on diseases once thought to be rare in Africa. They
* Adewale Adebajo
a.o.adebajo@sheffield.ac.uk
1 Department of Clinical Medicine and Therapeutics, College of
Health Sciences, University of Nairobi/Kenyatta National Hospital,
Nairobi, Kenya
2 Nairobi Arthritis Clinic, Nairobi, Kenya
3 Louisiana State University School of Medicine, New Orleans, LA,
USA
4 Faculty of Medicine, Dentistry and Health, University of Sheffield,
Sheffield, UK
Clin Rheumatol
DOI 10.1007/s10067-017-3761-z
range from rheumatoid arthritis, lupus, gout, myositis to rheumatology
in HIV. Research articles published in the journal
shows rheumatoid arthritis, juvenile idiopathic arthritis, systemic
lupus erythematosus, and antiphospholipid syndrome to
be increasing in frequency in the indigenous populations of
East, West, Central, and Southern Africa [4–7]. The HIV pandemic
has changed the epidemiological spectrum of diseases
in Africa. It has led to an increase in a variety of previously
rarely seen conditions like spondyloarthropathies, fibromyalgia,
pyomyositis, and scleroderma. Various scholars have
shared their experiences in the journal [8–12]. The journal
has also provided a forum through which scholars have been
able to share their experiences in management of the rheumatic
diseases with biologic therapy. The results have been similar
to data from around the world [13, 14]. Case reports of rare
diseases and review articles have not been left out and have
enriched the content of the journal bringing diversity in the
articles published.
The visibility of the journal is hampered by the low scholarly
output. This is in part due to severe limitations in the
overall economic development and especially in research infrastructure.
Researchers have limited access to funding for
research as most African countries have no national agencies
that are responsible for research. This is compounded by limitations
in scientific writing, designing, and conducting research
and in reporting the results. Partnership with international
journals like the African Journal Partnership Project is
welcome to bridge that gap by training African health researchers
to improve the quality and visibility of their research
and make the Africa journal of rheumatology a better resource
for local researchers and policy makers [15].
This journal has become a site for exchange of knowledge
of local rheumatic diseases, research, and debate and providing
a forum through which international research can be made
applicable to the African set-up. The Africa Journal of
Rheumatology encourages international agencies, which conduct
research in the region to support the journal through
submission of research and subscription to the publication. It
is our hope that this journal will provide a big step to bridge
the big gaps in rheumatology in Africa.
Compliance with ethical standards
Disclosures None.
References
1. Worldometers (2017) (www.Worldometers.info)
2. Horton R (2000a) Development aid: manna or myth? Lancet 356:
1044–1045
3. Espinoza LR (2014) Welcoming an African asset: African Journal
of Rheumatology. Afr J Rheumatol 2(2):47–48
4. Otieno FO, Moots RJ, Oyoo GO (2017) Rheumatoid arthritis in
Kenya. Afr J Rheumatol 5(1):1–2
5. Akintayo RO, Aworinde OO, Olawumi HO, Yusuf IA (2016)
Antiphospholipid syndrome in Africa: a review. Afr J Rheumatol
3(1):3–8
6. Genga EK, Otieno FO, Oyoo GO (2015) Clinical profiles of patients
SLE in Nairobi. Afr J Rheumatol 3(2):62–66
7. Adelowo F (2013) Systemic lupus erythematosus: not a rare disease
among black Africans. Afr J Rheumatol 1(2):46–47
8. Oyoo GO, Genga EK, Otieno FO, Omondi EA (2016) Clinical
patterns of juvenile idiopathic arthritis: a single tertiary centre experience
in Kenya Nairobi. Afr J Rheumatol 4(2):66–71
9. Venkat R, Jawad ASM, Chikanza IC (2014) Spontaneous resolution
of a case of anti-retroviral treatment-naïve HIV-associated
polymyositis. Afr J Rheumatol 2(2):78–84
10. Ilovi S, Oyoo G (2013) Characteristics of systemic sclerosis patients
in Nairobi, Kenya: a retrospective study. Afr J Rheumatol 1(1):8–12
11. Malombe NM, Oyoo GO, Maritim MC, Kwasa J (2013) Prevalence
of fibromyalgia in ambulatory HIV positive patients with musculoskeletal
pain at Comprehensive Care Clinic, Kenyatta National
Hospital. Afr J Rheumatol 1(2):70–75
12. Ouédraogo DD, Ouédraogo T, Kaboré F et al (2013) Prevalence of
HIV infection among the patients with an avascular necrosis of the
femoral head in Ouagadougou, Burkina Faso Ouédraogo. Afr J
Rheumatol 1(2):57–60
13. Oyoo GO, Otieno FO, Mbuthia B, Omondi EA, Genga EK (2015)
Experience with rituximab in patients with rheumatoid arthritis in
Nairobi, Kenya. Afr J Rheumatol 3(1):17–21
14. Elhabbash B, Tarsin R (2017) Certolizumab effect in a cohort of 60
Libyan patients with rheumatic diseases. Afr J Rheumatol 5(1):19–
23
15. Muula AS (2008) Medical journals and authorship in low-income
countries. Croat Med J 49:681–683

Gor SO. "The African Regional Integration Index: a Selective Audit." Trade and Development Review. 2017;9(1-2):86-98.
Nyamai C, Daniel Ichang'i, Wamunyu AW, Feneyrol J, Giuliani G, et al. "Age and origin of the tsavorite and tanzanite mineralizing fluids in the Neoproterozoic Mozambique Metamorphic Belt." The Canadian Mineralogist. 2017;55(4):763-786. AbstractFull Text

The genetic model previously proposed for tsavorite- (and tanzanite-) bearing mineralization hosted in the Neoproterozoic Metamorphic Mozambique Belt (stretching from Kenya through Tanzania to Madagascar) is refined on the basis of new Sm-Nd age determinations and detailed Sr-O-S isotope and fluid-inclusion studies. The deposits are hosted within meta-sedimentary series composed of quartzites, graphitic gneisses, calc-silicate rocks intercalated with meta-evaporites, and marbles. Tsavorite occurs either in nodules (also called “boudins”) oriented parallel to the metamorphic foliation in all of the deposits in the metamorphic belt or in quartz veins and lenses located at the hinges of anticlinal folds (Lelatema fold belt and Ruangwa deposits, Tanzania). Gem tanzanite occurs in pockets and lenses in the Lelatema fold belt of northern Tanzania.

The Sm-Nd isotopic data for tsavorites and tanzanites hosted in quartz veins and lenses from Merelani demonstrate that they formed at 600 Ma, during the retrograde metamorphic episode associated with the East African Orogeny. The tsavorites hosted in nodules do not provide reliable ages: their sedimentary protoliths had heterogeneous compositions and their Sm-Nd system was not completely rehomogenized, even at the local scale, by the fluid-absent metamorphic recrystallization.

The initial 87Sr/86Sr isotopic ratios of calcite from marble and tanzanites from Merelani fit with the strontium isotopic composition of Neoproterozoic marine carbonates. Seawater sediment deposition in the Mozambique Ocean took place around 720 Ma.

The quartz-zoisite O-isotopic thermometer indicates a temperature of formation for zoisite between 385 and 448 °C.

The sulfur isotopic composition of pyrite (between –7.8 and –1.3‰ V-CDT) associated with tsavorite in the Lelatema fold belt deposits suggests the contribution of reduced marine sulfate. The sulfur in pyrite in the marbles was likely derived from bacterial sulfate reduction which produced H2S. Fluid inclusion data from tsavorite and tanzanite samples from the Merelani mine indicate the presence of a dominant H2S-S8±(CH4)±(N2)±(H2O)-bearing fluid. In the deposits in Kenya and Madagascar, the replacement of sulfate by tsavorite in the nodules and the boron isotopic composition of tourmaline associated with tsavorite are strong arguments in favor of the participation of evaporites in garnet formation.

Chimoita EL, Onyango CM, John W. Kimenju, Gweyi-Onyango JP. "Agricultural Extension Approaches Influencing Uptake of Improved Sorghum Technologies in Embu County, Kenya." Universal Journal of Agricultural Research . 2017;5(1):45-51.
GT AROTIBA, J HILLE, Guthua SW, H ADEOLA, W ODHIAMBO. "Ameloblastoma in Black Africans the Need for Multi-National Collaborative Research." JSM Dent Surg. 2017;2(2):10-14.
and Gakuubi MWAWJM 4. "Antifungal activity of essential oil of Eucalyptus camaldulensis Dehnh. against selected Fusarium spp.". 2017. Abstracthttps://profiles.uonbi.ac.ke/mainawagacha/

The objective of this study was to evaluate the antifungal activity of essential oil (EO) of
Eucalyptus camaldulensis Dehnh. against five Fusarium spp. commonly associated with
maize. The essential oil had been extracted by steam distillation in a modified Clevenger-
type apparatus from leaves of E. camaldulensis and their chemical composition
characterized by gas chromatography mass spectrometry. Poisoned food technique was
used to determine the percentage inhibition of mycelial growth, minimum inhibitory …

Waithaka PN, Mwaura FB, Wagacha JM, Gathuru EM, Githaiga BM. "Antimicrobial Properties of Actinomycetes Isolated from Menengai Crater in Kenya." CellBio. 2017;06(2):13.
Muthaura CN, Keriko JM, Mutai C, Yenesew A, Heydenreich M, Atilaw Y, Gathirwa JW, Irungu BN, Derese S. "Antiplasmodial, Cytotoxicity and Phytochemical Constituents of Four Maytenus Species Used in Traditional Medicine in Kenya." The Natural Products Journal. 2017;7(2):144-152.
Muthaura CN, Keriko JM, Mutai C, Yenesew A, Heydenreich M, Atilaw Y, Gathirwa JW, Irungu BN, Derese S. "Antiplasmodial, Cytotoxicity and Phytochemical Constituents of Four Maytenus Species Used in Traditional Medicine in Kenya." The Natural Products Journal. 2017;7(2):144-152. AbstractJournal article

Description
Background:
In Kenya, several species of the genus Maytenus are used in traditional medicine to treat many diseases including malaria. In this study, phytochemical constituents and extracts of Maytenus undata, M. putterlickioides, M. senegalensis and M. heterophylla were evaluated to determine compound/s responsible for antimalarial activity.
Objective:
To isolate antiplasmodial compounds from these plant species which could be used marker compounds in the standardization of their extracts as a phytomedicine for malaria.
Methods:
Constituents were isolated through activity-guided fractionation of the MeOH/CHCl3 (1:1) extracts and in vitro inhibition of Plasmodium falciparum. Cytotoxicity was evaluated using Vero cells and the compounds were elucidated on the basis of NMR spectroscopy.
Results:
Fractionation of the extracts resulted in the isolation of ten known compounds. Compound 1 showed …
Total citations
Cited by 1
2018
Scholar articles
Antiplasmodial, Cytotoxicity and Phytochemical Constituents of Four Maytenus Species Used in Traditional Medicine in Kenya
CN Muthaura, JM Keriko, C Mutai, A Yenesew… - The Natural Products Journal, 2017
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A. WG, D. A, Aluoch A. O., G.N. K, I. M. "Application of Eburru Rocks from Kenya as Urea Carrier Agents." International Journal of Recent advances in Multidisplinary Research. 2017;4(4):2532-2541.
J.M.Mahasi, H.A.Ogot, Okoth SA, G.O.Obiero. "Assesment of Asian soybean rust (Phakopsora pachyrhizi) disease severity in selected districts of Western Kenya." International Journal of Agronomy and Agricultural Research. 2017;11(2):50-53.
Gichamba A, Wagacha PW, Ochieng DO. "An Assessment of e-Extension Platforms in Kenya.". 2017. Abstract

The use of ICT in agriculture within developing countries has quickly gained
popularity among development agencies, the private sector and even the government. ICT
for agriculture (ICT4Ag) services such as trade platforms, notification platforms and
advisory/extension services have been developed. This has been catalyzed by the growing
number of farmers with access to ICT devices such as mobile phones. Among the available
services, advisory/extension platforms have gained popularity among farmers an

Gichamba A, Wagacha PW, Ochieng DO. "An Assessment of e-Extension Platforms in Kenya." International Journal of Innovative Studies in Sciences and Engineering Technology . 2017;3(7):36-40. Abstractfull text link

The use of ICT in agriculture within
developing countries has quickly gained popularity
among development agencies, the private sector and
even the government. ICT for agriculture (ICT4Ag)
services such as trade platforms, notification platforms
and advisory/extension services have been developed.
This has been catalyzed by the growing number of
farmers with access to ICT devices such as mobile
phones. Among the available services, advisory/extension
platforms have gained popularity among farmers and
agriculture stakeholders in the developing world. These
platforms have proven to be of importance to farmers
who are curious about new farming methodologies,
strategies to improve their yields, breeding techniques,
among other factors. The ICT platforms employed
include SMS, mobile applications, Interactive Voice
Response systems, social media platform such as
Facebook and Twitter, chat applications such as
Whatsapp, blogs, radio programs and tv programs. The
aim of this research was to assess the e-Extension
platforms used in Kenya, whose purpose is to advise
millions of farmers across different parts of the country
using ICT platforms. 28 government e-Extension officers
employed to advise farmers using ICT platforms were
interviewed. The officers represented 15 different
counties in Kenya. The study made important findings
that would inform the government, agriculture extension
content providers, and other stakeholders on critical
aspects to be considered in deploying and managing eextension
platforms among a population of diverse users
within a developing country.

Gichamba A, Wagacha PW, Ochieng DO. "An Assessment of e-Extension Platforms in Kenya." International Journal of Innovative Studies in Sciences and Engineering Technology (IJISSET). 2017;3:36-40. Abstract

The use of ICT in agriculture within developing countries has quickly gained popularity among development agencies, the private sector and even the government. ICT for agriculture (ICT4Ag) services such as trade platforms, notification platforms and advisory/extension services have been developed. This has been catalyzed by the growing number of farmers with access to ICT devices such as mobile phones. Among the available services, advisory/extension platforms have gained popularity among farmers and agriculture stakeholders in the developing world. These platforms have proven to be of importance to farmers who are curious about new farming methodologies, strategies to improve their yields, breeding techniques, among other factors. The ICT platforms employed include SMS, mobile applications, Interactive Voice Response systems, social media platform such as Facebook and Twitter, chat applications such as Whatsapp, blogs, radio programs and tv programs. The aim of this research was to assess the e-Extension platforms used in Kenya, whose purpose is to advise millions of farmers across different parts of the country using ICT platforms. 28 government e-Extension officers employed to advise farmers using ICT platforms were interviewed. The officers represented 15 different counties in Kenya. The study made important findings that would inform the government, agriculture extension content providers, and other stakeholders on critical aspects to be considered in deploying and managing eextension platforms among a population of diverse users within a developing country.

Gachago MM, AG K. "Branch Retinal Vein Occlusions. A Review." JOECSA. 2017;21(1):1-8.
Martelat J-E, Paquette J-L, Bosse V, Giuliani G, Monié P, Omito E, Simonet C, Ohnenstetter D, Daniel Ichang'i, Nyamai C, Wamunyu A. "Chronological Constraints On Tsavorite Mineralizations and Related Metamorphic Episodes In Southeast Kenya." The Canadian Mineralogist. 2017;55(5):845-865. AbstractFull text link

Tsavorite is exclusively hosted in the Neoproterozoic Metamorphic Mozambique Belt (NMMB). The gemstone mines, widespread between Kalalani (Tanzania) and Mgama Ridge (Kenya), define a continuous corridor over a hundred kilometers in length. The tsavorite is hosted by a metasedimentary sequence defined as the Kurase tsavorite-bearing metasediments (Kurase-TB metasediments) that also hosts rubies. These metasediments underwent amphibolite-facies metamorphism and are surrounded by granulitic gneisses that are also of sedimentary origin (the Kurase high-temperature gneisses). All these rocks lie below the Kasigau Group, a unit dominated by granulite-facies metamagmatic rocks.

To constrain the timing of events that led to this peculiar occurrence of tsavorite, we have performed geochronological analyses of thin sections and of separated grains of zircon, monazite, and rutile using LA-ICP-MS and ID-TIMS, as well as 40Ar/39Ar of muscovite and phlogopite from various lithologies. The results show that the different terranes were metamorphosed synchronously between 620–580 Ma but under different P-T strain conditions. The Kurase-HT gneisses and the rocks from the Kasigau Group are highly strained and underwent granulite-facies metamorphism with abundant partial melting and emplacement of felsic melts between 620 and 600 Ma. Textural observations also underlined a late regional water flux controlling the occurrence of V-free muscovite and monazite mineralizations at 585 Ma. The latter event can be related to the activity of the Galana shear zone, in the east. The Kurase-TB metasediments escaped strain and partial melting. They record amphibolite-facies conditions with static heating, since initial sedimentary structures were locally preserved. The age of the tsavorite mineralization was inferred at 600 Ma from metamorphic zircon rims and monazite from the closest host-rocks, sampled in the mines. Hence, tsavorite crystallization occurred statically at the end of the metamorphic event, probably when the temperature and the amount of volatiles were at maximum levels.

Conversely, the ruby formed by local metasomatism of felsic dikes and isolated ultramafic bodies. The rubies are older and zircons and monazites from a ruby-bearing felsic dike (plumasite) were dated at 615 Ma. Finally, data from rutile and micas indicate a global cooling below 430 °C of the whole region between 510 and 500 Ma.

Gichobi AN, Ndwigah SN, Sinei KA, Guantai EM. "Clinical audit of Heparin use in Rift Valley General Hospital, Nakuru County, Kenya. ." Afr. J. Pharmacol. Ther. . 2017;6(1):27-37.
Gichobi 2. AN, Ndwigah SN, Sinei KA, Guantai EM. "Clinical audit of Heparin use in Rift Valley General Hospital, Nakuru County, Kenya." African Journal of Pharmacology and Therapeutics. 2017;6(1):27-37.
Nyawira M, Muchai G, Gichangi M, Gichuhi S, Githeko K, Atieno J, Karimurio J, Kibachio J, Ngugi N, Nyaga PT, Nyamori J, Zindamoyen ANM, Bascaran C, Foster A. "Clinical guidelines for diabetic retinopathy in Kenya: an executive summary of the recommendations." J Ophthalmol East Cent & S Afr. . 2017;21(2):33-39. Abstract

All persons living with Diabetes Mellitus (DM) have a lifetime risk of developing Diabetic Retinopathy (DR), a
potentially blinding microvascular complication of DM. The risk increases with the duration of diabetes. The
onset and progression of DR can be delayed through optimization of control of blood glucose, blood pressure and lipids. The risk of blindness from DR can be reduced through cost-effective interventions such as screening for DR and treatment of sight-threatening DR with laser photocoagulation and anti-VEGF medications.
Several factors make it important to provide guidance to clinicians who provide services for diabetes and
diabetic retinopathy in Kenya. First, the magnitude of both DM and DR is expected to increase over the next
decade. Secondly, as the retina is easily accessible for examination, the early signs of retinopathy may provide clinicians with the best evidence of microvascular damage from diabetes. This information can be used to guide subsequent management of both DM and DR. Thirdly, there are notable gaps in service delivery for the detection,treatment and follow-up of patients with DR, and the services are inequitable. Strengthening of service delivery will require close collaboration between diabetes services and eye care services.
Following a systematic and collaborative process of guideline development, the first published national
guidelines for the management of diabetic retinopathy have been developed. The purpose of this paper is to
highlight the recommendations in the guidelines, and to facilitate their adoption and implementation.

N M, M G, M G, Gichuhi S, G K, A J’o. "Clinical guidelines for diabetic retinopathy in Kenya: An executive summary of the recommendations." JOECSA. 2017;21(2):33-39.
Mwangi N, Gachago M, Gichangi M, Gichuhi S, Githeko K, Jalango A, Karimurio J, Kibachio J, Ngugi N, Nyaga P, Nyamori J, Zindamoyen ANM, Bascaran C, Foster A. "Clinical guidelines for diabetic retinopathy in Kenya: an executive summary of the recommendations." J Ophthalmol East Cent & S Afr.. 2017;21(2):33-9.
Gwako Bosibori Jackline RTHM&. "A Comperative Analysis of Virtue-Based Content for Youth in Two Epics in Swahili." International Journal of Language and Linguistics . 2017;4(2374-8850 (Print) 2374-8869 (online)):200-215 .
Gwako Bosibori Jackline RTHM&. "A Comperative Analysis of Virtue-Based Content for Youth in Two Epics in Swahili: Siraji na Adili." International Journal of Language and Linguistics . 2017;4(4):200-215 .
G EL, BA K, F O, T D, RJ M. "Complications associated with crowns and fixed partial dentures provided to patients at a teaching hospital." International journal of multidisciplinary research review. 2017;1(32):19-24.publication_ijmdrr.pdf
G KAMAU, A WAUSI NJIHIAJ. "CONTEXTUAL FACTORS AND PUBLIC VALUE OF E-GOVERNMENT SERVICES IN KENYA.". 2017. Abstractfull text link

E-government research has been skewed towards technological deterministic
perspective mainly centering on technological issues. This provides no explicit guidance to
the design and practice of e-government programs that result to increased uptake of e-
government services. Theoretical discourse reveals undisputed consensus among e-
government researchers that e-government uptake may be influenced by others contextual
factors such as administrative and political consequences and should not be overlooked

K.Muriithi M, G.Mutegi R, Mwabu G. "Counting unpaid work in Kenya: Gender and age profiles of hours worked and imputed wage incomes." The journal of the Economics Aging. 2017.
Kihara EN  , P G, Liversidge HM, F B, Gikenye. "Dental age estimation in a group of Kenyan children using Willems' method: a radiographic study." Ann Hum Biol. 2017;44:614-621(7):614-621.
Gichamba A, Wagacha PW, Ochieng DO. "Designing mAgriculture Applications for Rural Smallholder Farmers.". 2017. Abstract

ICT has been widely accepted and adopted as a key driver for various sectors of
the economy for both the developing and developed nations. In developing countries, there
have been multiple interventions to employ the available technology such as mobile,
wireless, radio and TV technologies in key areas that concern human development such as
health, agriculture, education and finance. The design and development practices, are
mostly borrowed from established markets with different user profiles, and do not always

English MM, Irimu GG, Nyamai RR, Were FF, Garner PP, Opiyo NN, F W. "Developing guidelines in low-income and middle-income countries: lessons from Kenya." Arch Dis Child. 2017;1(6). AbstractWebsite

There are few examples of sustained nationally organised, evidence-informed clinical guidelines development processes in Sub-Saharan Africa. We describe the evolution of efforts from 2005 to 2015 to support evidence-informed decision making to guide admission hospital care practices in Kenya. The approach to conduct reviews, present evidence, and structure and promote transparency of consensus-based procedures for making recommendations improved over four distinct rounds of policy making. Efforts to engage important voices extended from government and academia initially to include multiple professional associations, regulators and practitioners. More than 100 people have been engaged in the decision-making process; an increasing number outside the research team has contributed to the conduct of systematic reviews, and 31 clinical policy recommendations has been developed. Recommendations were incorporated into clinical guideline booklets that have been widely disseminated with a popular knowledge and skills training course. Both helped translate evidence into practice. We contend that these efforts have helped improve the use of evidence to inform policy. The systematic reviews, Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approaches and evidence to decision-making process are well understood by clinicians, and the process has helped create a broad community engaged in evidence translation together with a social or professional norm to use evidence in paediatric care in Kenya. Specific sustained efforts should be made to support capacity and evidence-based decision making in other African settings and clinical disciplines.

Okumu PO, Karanja DN, Gathumbi PK. Diseases of domestic rabbits and associated risk factors in Kenya. Germany : LAP LAMBERT Academic Publishing ; 2017.
Nyaga LW, Gach. "Distance Learning Approach to Train Health Sciences Students at the University of Nairobi." East African Medical Journal. 2017;94(February 2017):101-105.
Mutegi R.G., Muriithi. M.K., G. W. "Education Policies in Kenya : Does Free Secondary Education Promote Equity in Public Secondary Schools?" In International Journal of Development Research. 2017;7(11):16696-16699 .abstract2.pdf
Ombega NJ, S. M. Mureithi, O. K. Koech, Karuma AN, Gachene CKK. "Effect of rangeland rehabilitation on the herbaceous species composition and diversity in Suswa catchment, Narok County, Kenya." Ecological Processes. 2017.
Ombega NJ, S. M. Mureithi, O. K. Koech, Karuma AN, Gachene CKK. "Effect of rangeland rehabilitation on the herbaceous species composition and diversity in Suswa catchment, Narok County, Kenya." Ecological Processes. 2017.
Ombega NJ, S. M. Mureithi, O. K. Koech, Karuma AN, Gachene CKK. "Effect of rangeland rehabilitation on the herbaceous species composition and diversity in Suswa catchment, Narok County, Kenya." Ecological Processes. 2017.
Ombega NJ, Mureithi SM, Koech OK, Karuma AN, Gachene CKK. "Effect of rangeland rehabilitation on the herbaceous species composition and diversity in Suswa catchment, Narok County, Kenya." Ecological Processes. 2017;6(1):41.
GITHINJI EDWARD, IRUNGU LUCY, Ndegwa P, ATIELI FRANCIS, MACHANI MAXWEL. "Effects of kdr gene frequencies on major malaria vectors’ resting behaviour in Teso sub-counties, western Kenya." THE KASH 7 ABSTRACT SUBMISSION. 2017.
GITHINJI EDWARD, IRUNGU LUCY, Ndegwa P, ATIELI FRANCIS, MACHANI MAXWEL. "Effects of kdr gene frequencies on major malaria vectors’ resting behaviour in Teso sub-counties, western Kenya." THE KASH 7 ABSTRACT SUBMISSION. 2017.
GITHINJI EDWARD, IRUNGU LUCY, Ndegwa P, ATIELI FRANCIS, KEMEI BRIGID, AMITO RICHARD, OMBOK MAURICE, WANJOYA ANTONY, M CHARLES. "Effects of target-site insecticide resistance on major malaria vectors’ biting patterns and entomological inoculation rates in Teso sub counties, western Kenya." THE KASH 7 ABSTRACT SUBMISSION. 2017.
GITHINJ EDWARD, IRUNGU LUCY, Ndegwa P, ATIELI FRANCIS, KEMEI BRIGID, AMITO RICHARD, OMBOK MAURICE, WANJOYA ANTONY, Mbogo CM, MATHENGE EVAN. "Effects of target-site insecticide resistance on major malaria vectors’ biting patterns and entomological inoculation rates in Teso sub counties, western Kenya." THE KASH 7 ABSTRACT SUBMISSION. 2017.
GITHINJI EDWARD, IRUNGU LUCY, Ndegwa P, ATIELI FRANCIS, KEMEI BRIGID, AMITO RICHARD, OMBOK MAURICE, WANJOYA ANTONY, Mbogo CM, MATHENGE EVAN. "Effects of target-site insecticide resistance on major malaria vectors’ biting patterns and entomological inoculation rates in Teso sub counties, western Kenya." THE KASH 7 ABSTRACT SUBMISSION. 2017.
Gichuhi S, Gichangi M, Nyamori J, Gachago M, Nyenze EM, Nyaga PT, Karimurio J. "Evaluation of the Kenyatta National Hospital diabetic retinopathy screening program 2015-2016." J Ophthalmol East Cent & S Afr. . 2017;21(2):40-44. Abstract

Objective: This operational evaluation was conducted to determine the effect of having a screening fundus
camera in the diabetes clinic on the demand for eye clinic diabetic retinopathy services at the Kenyatta National Hospital (KNH).
Methods: A before-after evaluation design was used. The reference point was installation of a screening retinal fundus camera in the KNH diabetes clinic in May 2016. The ‘before’ period was January to June 2015 and the ‘after’ period was June to November 2016. The one-year gap between the evaluation periods was used for program development and user training. The primary measure of outcome was a comparison of the mean numbers of patients seen and treated before and after starting the screening program. Data was obtained from the medical records on both the diabetes and eye clinics.
Results: The total number of diabetic patients screened in the two periods was 3011 (monthly mean=502,
SD=44) and 2739 (monthly mean=457, SD=38) respectively. The total number referred to the eye clinic increased from 494 (monthly mean=82, SD=16) to 1065 (monthly mean=178, SD=30) while the total number of patients treated with lasers or intravitreal injections increased from 107 (monthly mean=18, SD=5) to 333 (monthly mean=56, SD=39).
Conclusions: Starting a diabetic retinopathy screening program using a fundus camera used based at the
diabetes clinic doubled the number of patients referred for further evaluation at the eye clinic (2.2-fold increase) and tripled the number of diabetics who received treatment for diabetic retinopathy (3.1-fold increase).

Gichuhi S, Gichangi M, Nyamori J, Gachago M, Nyenze M, Nyaga PT, Karimurio J. "Evaluation of the Kenyatta National Hospital diabetic retinopathy screening program 2015-2016 ." J Ophthalmol East Cent & S Afr.. 2017;21(2):40-5.
Gichuhi S, M G, J N, M G, E NYENZE, P N, J K. "Evaluation of the Kenyatta National Hospital diabetic retinopathy screening program 2015-2016." JOECSA. 2017;21(2):40-44.
Gichuhi S, M G, J N, M G, EM N, T NP, J K. "Evaluation of the Kenyatta National Hospital diabetic retinopathy screening program 2015-2016." JOECSA. 2017;21(2):14-18.
Gitonga P, Karani A, Kimani S. "Explore Best Practices in Family Nursing in Kenya: Empathy as a Value in Caring." http://www.opastonline.com/journal-of-nursing-healthcare/. 2017;2(2):1/4.
Kang’ethe EK, Gatwiri M, Sirma AJ, Ouko EO, Mburugu-Musoti CK, Kitala PM, Nduhiu GJ, Nderitu JG, JK Mungatu, Hietaniemi V, V Joutsjoki, Korhonen HJ. "Exposure of Kenyan population to aflatoxins in foods with special reference to Nandi and Makueni counties." Food Quality and Safety. 2017;1 (2):131-137.
Gichure, N.G., Wahome, R.G., Njage, P.K., Karuri, H. W., Nzuma, M.J., Karantininis, K. "Factors influencing extent of traceability along organic fresh produce value chains: case of kale in Nairobi, Kenya." Organic Agriculture. 2017;7(3):293-302.
Ogolla KO, Chebet J, Gathumbi PK, Waruiru RM, Okumu PO, W. K Munyua, Kibebe HW. "Farmer practices that influence risk factors, prevalence and control strategies of rabbit coccidiosis in Central Kenya." Livestock Research for Rural Development. 2017;29(7).www_lrrd_org_lrrd29_7_koko29134_html.pdf
Opuko Hellen A., G. MM. "Flexible Work Practices and Job Performance in the Transport and Logistics Industry: The Kenyan perspective." DBA Africa Management Review. 2017;7(2):38-49.
Gakuu, C. M. KKHJ & PN. Fundamentals of Research Methods: Concepts, Theories and Application. Aura Publishers, Nairobi; 2017.
Jakubowski H, Xie J, Mitra AK, Ghooi R, Hosseinkhani S, Alipour M, Hajipour B, Obiero G. "The Global Ethics Corner: foundations, beliefs, and the teaching of biomedical and scientific ethics around the world." Biochemistry and Molecular Biology Education. 2017;45(5):385-395. Abstract

The profound advances in the biomolecular sciences over the last decades have enabled similar advances in biomedicine. These advances have increasingly challenged our abilities to deploy them in an equitable and ethically acceptable manner. As such, it has become necessary and important to teach biomedical and scientific ethics to our students who will become the researchers, medical professionals, and global citizens of the future. As advances in the biosciences and medicine are made, developed, and used across the globe, our survival on an endangered planet requires global dialog and consensual action. To that end, a group of us from around the world have come together to describe the differing foundations of our ethical beliefs, and how ethical issues in biomedicine and in science are described and confronted in our countries. We hope to show the commonality in our beliefs and practices.

Serem JK, Wahome RG, D.W. Gakuya, S.G.Kiama, G.C.Gitao, D, W O. "Growth performance, feed conversion efficiency and blood characteristics of growing pigs fed on different levels of Moringa oleifera leaf meal." Journal of Veterinary Medicine and Animal health . 2017;9(11):327-333.serem_et_al_2017.pdf
Serem JK, G WR, DW G, SG K, G GC, DW O. "Growth performance, feed conversion efficiency and blood characteristics of growing pigs fed on different levels of Moringa oleifera leaf meal." Journal of Veterinary Medicine and Animal Health. 2017;9(11):327-333.serem_et_al_2017.pdf
N M, M G, Gichuhi S, G K, N N, L M, M B. Guidelines For Screening And Management of Diabetic Retinopathy. Nairobi: Ministry of Health Kenya; 2017.
Gatari MJ, Kinney PL, Yan B, Sclar E, Volavka-Close N, Ngo N, Gaita SM, Law A, Ndiba PK, Gachanja A, Graeff J, Chillrud SN. "High airborne black carbon concentrations measured near roadways in Nairobi, Kenya. Transportation Research." Transportation Research Part D: Transport and Environment. 2017;68:99-109.
Serem Jared K., John M. Kimani, Raphael G. Wahome, Daniel W. Gakuya, G.Kiama S, Onyango DW, Mbuthia PG. "Histopathological Evaluation of Spleen, Liver and Kidneys from Pigs Fed on Moringa oleifera Leaf Meal Diets Global Veterinaria 19 (1): 478-486, .". 2017.
Ogara WO, Gitahi N, Mainga AO, Ongoro E. "Human carnivores conflict in Wamba District, Samburu County, Kenya." International Journal of Biodiversity and Conservation. 2017;Vol. 9(9):284-291.human_carnivore_conflic_in_wamba_samburu_county.pdf
G. W, Koriyow Hussein A. "Impact of Subsidised Fees on Students’ Access to Quality Education in Public Secondary Schools in Wajir County, Kenya. ." International Journal of Education and Research . 2017;5(7):247-262 .abstract.pdf
Falkenstrom F, Gee MG, Kuria MW, Othieno CJ, Kumar M. "Improving the effectiveness of psychotherapy in two public hospitals in Nairobi." BJP Psych. International. 2017;14(3).
Thuo BM, Thoithi GN, Maingi N, Ndwigah SN, Gitari RN, Otieno RO. "In vitro anthelmintic activity of Albizia gummifera, Crotalaria axillaris, Manilkara discolor, Teclea trichocarpa and Zanthoxylum usambarense using sheep nematodes." Afr. J. Pharmacol. Ther. 2017;6(1):38-42.
Motomura K, Ganchimeg T, Nagata C, Ota E, Vogel JP, Betran AP, Torloni MR, Jayaratne K, Jwa SC, Mittal S, Recidoro ZD, Matsumoto K, Fujieda M, Nafiou I, Yunis K, QURESHI ZAHIDA, Souza JP, Mori R. "Incidence and outcomes of uterine rupture among women with prior caesarean section: WHO Multicountry Survey on Maternal and Newborn Health." Scientific Reports. 2017;7. AbstractWebsite

Caesarean section (CS) is increasing globally, and women with prior CS are at higher risk of uterine rupture in subsequent pregnancies. However, little is known about the incidence, risk factors, and outcomes of uterine rupture in women with prior CS, especially in developing countries. To investigate this, we conducted a secondary analysis of the World Health Organization Multicountry Survey on Maternal and Newborn Health, which included data on delivery from 359 facilities in 29 countries. The incidence of uterine rupture among women with at least one prior CS was 0.5% (170/37,366), ranging from 0.2% in high-Human Development Index (HDI) countries to 1.0% in low-HDI countries. Factors significantly associated with uterine rupture included giving birth in medium- or low-HDI countries (adjusted odds ratio [AOR] 2.0 and 3.88, respectively), lower maternal educational level (≤6 years) (AOR 1.71), spontaneous onset of labour (AOR 1.62), and gestational age at birth <37 weeks (AOR 3.52). Women with uterine rupture had significantly higher risk of maternal death (AOR 4.45) and perinatal death (AOR 33.34). Women with prior CS, especially in resource-limited settings, are facing higher risk of uterine rupture and subsequent adverse outcomes. Further studies are needed for prevention/management strategies in these settings.

Use of caesarean section (CS) deliveries has been steadily increasing, from 6.7% in 1990 to 19.1% in 2014 globally1,2. Consequently, the number of deliveries by mothers with prior CS is also on the rise1.

Women with prior CS are at higher risk of uterine rupture. The reported incidence of uterine rupture among women with prior CS ranged from 0.22% to 0.5% in some developed countries3,4,5,6. The risk factors for uterine rupture in women with a history of CS include prior classical incision, labour induction or argumentation, macrosomia, increasing maternal age, post-term delivery, short maternal stature, no prior vaginal delivery, and prior periviable CS4,7,8,9,10,11. Uterine rupture poses considerable risk of adverse maternal and perinatal outcomes. The prevalence of maternal and perinatal complications, such as severe post-hemorrhagic anemia, major puerperal infection, bladder injury, hysterectomy, and perinatal mortality, are significantly higher in women with uterine rupture than women without uterine rupture4,10,12,13.

A World Health Organization (WHO) systematic review to determine the prevalence of uterine rupture worldwide identified uterine rupture as a serious obstetric complication being more prevalent and with more serious consequences in developing countries than in developed countries14. In developing countries, uterine rupture has been reportedly associated with obstructed labour, grand multiparity, injudicious obstetric interventions/manipulations, lack of antenatal care, unbooked status, poor access to emergency obstetric care, and low socioeconomic status rather than prior CS15,16,17,18. However, uterine rupture after prior CS is becoming more common as the availability of CS increases in these settings18. According to a literature review on uterine rupture in developing countries, the proportion of women with prior CS or uterine scar among women who had uterine rupture was up to 64%18. A study in India reported that the incidence of uterine rupture among women with prior CS was 1.69%19. Nevertheless, there are few studies about the incidence, risk factors, and outcomes of uterine rupture among women with prior CS from these settings.

Typically, uterine rupture occurs suddenly and requires immediate critical emergency care for mothers, fetuses, or neonates. The strategies for prevention and management, as well as the quality of affordable care for women at risk of or experiencing uterine rupture, are likely to vary across settings depending on their diagnostic capacity, availability of obstetric interventions, and human and facility resources. Therefore, the findings in developed countries may not be generalizable to low-resource countries and settings. The aim of this analysis was to describe the incidence, risk factors, and maternal and perinatal outcomes of uterine rupture among women with prior CS using data from the WHO Multicountry Survey on Maternal and Newborn Health (WHOMCS), which was conducted in facilities in 29 countries worldwide from 2010 to 2011.

Gichuyia LN. INDOOR OVERHEAT- ING RISK: A FRAMEWORK FOR TEMPORAL BUILDING ADAPTATION DECISION-MAKING. Cambridge, London: University of Cambridge - https://doi.org/10.17863/CAM.17146; 2017.
Kimuyu DM, Veblen KE, Riginos C, Chira RM, GITHAIGA JOHNM, Young TP. "Influence of cattle on browsing and grazing wildlife varies with rainfall and presence of megaherbivores." Ecological Applications. 2017;27(3):786-798.
Mburu CW, Gaita SM, Knee CS, Gatari MJ, Karlsson M. "Influence of Yttrium Concentration on Local Structure in BaZr1−xYxO3−δ Based Proton Conductors." J. Phys. Chem.. 2017;121(30):16174-16181.
Ren Y, Gallucci JC, Kinghorn DA. "An Intramolecular CAr–H••• O= C Hydrogen Bond and the Configuration of Rotenoids." Planta medica. 2017;83(14/15):1194-1199. Abstract

Over the past half a century, the structure and configuration of the rotenoids, a group of natural products showing multiple promising bioactivities, have been established by interpretation of their NMR and electronic circular dichroism spectra and confirmed by analysis of single-crystal X-ray diffraction data. The chemical shift of the H-6′ 1H NMR resonance has been found to be an indicator of either a cis or trans C/D ring system. In the present study, four structures representing the central rings of a cis-, a trans-, a dehydro-, and an oxadehydro-rotenoid have been plotted using the Mercury program based on X-ray crystal structures reported previously, with the conformations of the C/D ring system, the local bond lengths or interatomic distances, hydrogen bond angles, and the H-6′ chemical shift of these compounds presented. It is shown for the first time that a trans-fused C/D ring system of rotenoids is preferred for …

Mwaniki O K, A A’oD, O OJ, G KJ. "Investigating the Effects of Formulation, and Geographical Location on Degradation of Carbendazim in French Beans, Kenya." The International Journal of Science & Technology . 2017;5(2):44-51.
Waithaka PN, Mwaura FB, Wagacha JM, Gathuru EM. "Isolation of Actinomycetes from Geothermal Vents of Menengai Crater in Kenya." Int J Mol Biol Open Access. 2017;2(5):00031.
A WG, D. A, O. AA, GN K, I.N M, J.K M. "Kinetics and Isothermal Studies of Lambda Cyhalothrin Sorption on eburru Soils in Kenya." Journal of Kenya Chemical Society. 2017;10(1):24-34.
Kang’ethe EK, H Korhonen, KA Marimba, G Nduhiu, JK Mungatu, Okoth SA, V Joutsjoki, LW Wamae, Shalo P. "Management and mitigation of health risks associated with the occurrence of mycotoxins along the maize value chain in two counties in Kenya." Food Quality and Safety. 2017;1(4):268-274.
Kang’ethe EK, H Korhonen, KA Marimba, G Nduhiu, JK Mungatu, Okoth SA, V Joutsjoki, LW Wamae. "Management and mitigation of health risks associated with the occurrence of mycotoxins along the maize value chain in two counties in Kenya." Food Quality and Safety,. 2017;1(4):268-274.
Derese S, Guantai EM, Yaouba S, Kuete V. "Mangifera indica L. (Anacardiaceae).". In: Medicinal Spices and Vegetables from Africa. London: Elsevier Academic Press; 2017.
Okumu MO, Ochola FO, Mbaria JM, Kanja LW, Gakuya DW, Kinyua AW, Okumu PO, Kiama SG. "Mitigative effects of Moringa Oleifera against liver injury induced by artesunate-amodiaquine antimalarial combination in wistar rats." Clinical Phytoscience. 2017;3(18):1-8.mitigative_effects_of_moringa_oleifera_against_liv.pdf
Okumu MO, Ochola FO, Mbaria JM, Kanja LW, Gakuya DW, Kinyua AW, Okumu PO, Kiama SG. "Mitigative effects of Moringa oleifera against liver injury induced by artesunate-amodiaquine antimalarial combination in wistar rats." Clinical Phytoscience,. 2017;3(1):18.mitigative_effect_moringa.pdf
Okumu MO, Ochola FO, Mbaria JM, Kanja LW, Gakuya DW, Kinyua AW, Okumu PO, Kiama SG. "Mitigative effects of Moringa oleifera against liver injury induced by artesunate-amodiaquine antimalarial combination in wistar rats." Clinical Phytoscience,. 2017;3(1):18.
Lorroki P, Muthomi J, Ininda J, Gichuru L, Githiri S, Wagacha. M. "Mode of Gene Action to Maize Streak Virus in Mid Altitude Inbred Lines CML202 and Osu23i." International Journal of Applied Science and Technology. 2017;7(3):9-18.
Mbugua JK, Guto PM, Madadi VO, Kamau GN. "Modeling of Experimental Adsorption Isotherm Data for Chlorothalonil by Nairobi River Sediment." IJSRSET,. 2017;3(5):259-268.
O.M.Ondimu, V.A.Ganesan, GATARI MJ, Marijnissen JCM, Agostinho LLF. "Modeling simple-jet mode electrohydrodynamic-atomization droplets' trajectories and spray pattern for a single nozzle system." Journal of Electrostatics. 2017;89:77-87.
Ru BL, Capdevielle-Dulac C, Musyoka BK, Goftishu M, Assefa Y, Ndemah R, Molo R, Chipab G. "Molecular phylogenetics and definition of the Acrapex minima Janse group (Lepidoptera, Noctuidae, Apameini, Sesamiina) with the description of four new species from the Afrotropics." Annales de la Société entomologique de France (NS). 2017;53(4):219-235.
Onyatta JO, Yusuf AO, Guto PM, Ooko JO. "The need for galvanizing and the corrosion environments in Kenya.". In: International Zinc Association and Afriken International Ltd Workshop. Norfok Hotel, Nairobi, Kenya; 2017.
Gitari A, Nguhiu J, Varma V, Mogoa E. "Occurrence, treatment protocols, and outcomes of colic in horses within Nairobi County, Kenya." Veterinary World. 2017;10(10):1255-1263.
gathece. "Oral Hygiene Status and gingival inflammation of Persons Living with HIV Attending Comprehensive Care Centre in Nairobi." International journal of innovative research and advanced studies. 2017.
UD A, K K, Gachago MM, A M. Outcome Of Age-Related Cataract Surgery At Specialist Hospital Sokoto, Nigeria In Year 2015. Nairobi: University of Nairobi; 2017.
Ru BL, Capdevielle-Dulac C, Musyoka BK, Pallangyo B, Njaku M, Goftishu M, Assefa Y, Sezonlin M, Ong’amo G, Kergoat GJ. "Phylogeny and systematics of the Acrapex apicestriata (Bethune-Baker, 1911) species complex (Lepidoptera, Noctuidae, Noctuinae, Apameini, Sesamiina) with the description of eight new species from the Afrotropics." Annales de la Société entomologique de France (NS). 2017;53(2):106-130.
NGUYAI CM, OGALO JP, Guthua SW, Odhiambo WA, Butt FM. "The potential of using 3D Printed Specific Models in Reconstructive Surgery of the Mandible." Afr. Journal of Oral Health Sciences (AJOHS). 2017;(1) 5:7-10.
Nyamu DG, Guantai AN, Osanjo GO, Mwatha E, Gitonga I, Kanyiri ML. "Predictors of Adequate Ambulatory Anticoagulation Services among Adult Patients in a Tertiary Teaching and Referral Hospital in Kenya." African Journal of Pharmacology and Therapeutics. 2017;6(1):20-26. Abstract2017_-_predictors_of_adequate_ambulatory_anticoagulation_services.pdf

Background: Local anticoagulation services are inadequate and substantially underutilized despite compelling evidence showing that their appropriate use significantly reduces the risk of thromboembolic complications.
Objectives: To determine the predictors of adequate ambulatory anticoagulation services in Kenyatta National Hospital.
Methodology: A cross sectional study between December 2014 and April 2015 among 102 adult outpatients on anticoagulation using consecutive sampling was done. Information abstracted into a predesigned data collection tool included participants’ sociodemographic characteristics, regular sources of supply of anticoagulant, clinic pre-appointment reminders, indications of treatment and international normalized ratio tests. Data were analyzed using IBM Statistical Package for Social Sciences version 21.0 and logistic regression was used to determine independent predictors of adequate anticoagulation, which was defined as international normalized ratio ranging 2 - 3.
Results: Females were majority (76.5 %) and only 27.5 % of patients had adequate anticoagulation control. The indication of warfarin for heart valve surgery (p=0.014) and deep venous thrombosis (p=0.021) were associated with adequate anticoagulation. Age above 60 years was associated with poor anticoagulation (p=0.006). Logistic regression revealed that the independent predictor of adequate anticoagulation was warfarin use due to heart valve surgery (OR=3.1; 95% CI: 1.2 – 7.9, p=0.017).
Conclusions: Ambulatory anticoagulation control in the hospital is poor. Further investigation is required to find out the reasons behind adequate anticoagulation in heart valve surgery patients.
Key Words: Ambulatory anticoagulation, anticoagulant, outpatient, international normalized ratio tests.

Mbui JM, Oluka MN, Guantai EM, Sinei KA, Achieng L, Baker A, Jande M, Massele A, Godman B. "Prescription patterns and adequacy of blood pressure control among adult hypertensive patients in Kenya; findings and implications." Expert Review of Clinical Pharmacology . 2017;10:1263-1271.
Okerosi EK, Okalebo FA, Opanga SA, Guantai AN. "Prevalence and risk factors for medication discrepancies on admission of elderly diabetics at Kenyatta National Hospital, Kenya. ." African Journal of Pharmacology and Therapeutics. 2017;6(1):54-63.
A O-R, GO O, E K, E G, F O, E O. "Prevalence of abnormal liver function tests in rheumatoid arthritis." Afr J Rheumatol . 2017;5(1):70-75. Abstractprevalence_of_abnormal_liver2.pdf

Abstract
Objective: To determine the prevalence
of Abnormal Liver Function Tests (LFTs)
in patients with rheumatoid arthritis
at the rheumatology out-patient clinic,
Kenyatta National Hospital (KNH).
Design: Cross-sectional descriptive
study.
Setting: Rheumatology out-patient clinic
at KNH.
Participants: One hundred and seven
RA patients.
Results: The overall prevalence of
abnormal LFTs in the study population
was 57%. The most common abnormal
LFTs were direct bilirubin and alkaline
phosphatase (ALP), which were elevated
in 34.6% and 15% of the study population,
respectively. Abnormal direct bilirubin
was associated with longer duration of
disease; adjusted Odds Ratio (OR) 0.54
(0.34, 0.86) p-value 0.009 and higher
disease activity, adjusted OR 2.79 (1.23,
6.25) p-value 0.014. Abnormal ALP
was significantly associated with BMI,
adjusted OR 0.205 (0.074, 0.57), p-value
0.002 as well as duration of disease,
adjusted OR 1.14 (1.013, 1.29), p-value
0.031.
Conclusion: This study found the
prevalence of liver dysfunction in
patients with rheumatoid arthritis to be
high, at 57%, and recommends regular
monitoring of liver function tests in
patients with rheumatoid arthritis.
Introduction
Rheumatoid Arthritis (RA) is a systemic,
chronic, progressive inflammatory
disease characterized by symmetric joint
polyarthritis that progresses to severe joint
destruction1
. As a systemic illness, RA
has many extra-articular manifestations
and co-morbidities, many of which have
been studied in our local setting, and
have been found to correlate with disease
activity2-5. The liver has however been
overlooked as a target organ in patients
with RA. Rheumatoid arthritis can affect
the liver in many ways6,7; dysfunction
is thought to arise from the disease
itself, independent autoimmune disease,
infections such as viral hepatitis or as a
consequence of anti-inflammatory drugs
such as Non-Steroidal Anti-Inflammatory
Drugs (NSAIDs) or Disease Modifying
Anti-Rheumatic Drugs (DMARDs)6
.
The most common DMARDs used
in treatment of RA in our setting are
methotrexate and leflunomide, which can
be hepatotoxic. The risk of hepatotoxicity
while on treatment with DMARDs may
be increased in the presence of hepatitis
or alcohol intake.
LFTs may be abnormal in up to
50% of patients with RA and this has
been shown to correlate with disease
activity7,8. The ‘rheumatoid liver’ has
long been a topic of interest and previous
studies noted histological changes in
the liver of RA patients who were not
on treatment with DMARDs such as
fatty change, cellular necrosis, chronic
passive congestion and gross atrophy9-12.
Studies have also investigated use of
multiple DMARDs, which were thought
to predispose patients with RA to a higher
risk of developing hepatotoxicity13,14.
With increasing awareness and
knowledge of the RA, more patients
are being diagnosed early and started
on treatment, which may be life-long.
Effective treatment modalities may have
hepatotoxic effects. Abnormal LFTs are
in themselves an independent predictor
of mortality15. Due to high mortality
from both RA as well as abnormal LFTs,
such a subset of patients could therefore
be at a higher risk. This is especially so
because we currently have limited ways
of managing liver injury in our setting.
It is therefore important for us to monitor
liver dysfunction in patients with RA.

JIN U, GO O, CF O, M M, N N. "Prevalence of fibromyalgia syndrome in diabetics with chronic pain at the Kenyatta National Hospital." Afr J Rheumatol . 2017; Vol. 5(1): 54-57. Abstractprevalence_of_fibromyalgia4.pdf

Abstract
Background: Fibromyalgia Syndrome
(FMS), an increasingly recognized
disorder with heightened response to
pressure, characterized by Chronic
Widespread Pain (CWP), for which no
other cause can be identified. Diabetes
Mellitus (DM) is the most common
metabolic endocrinopathy. It is estimated
that more than 50% of diabetic patients
will suffer from chronic disability.
Musculoskeletal complications of
diabetes may be as a consequence of DM
complications or direct associations e.g.
FMS.
Objectives: To determine the prevalence
of FMS in diabetics with chronic pain
and to determine the severity of FMS
related symptoms using the revised FMS
questionnaire (FIQR) tool.
Design: Descriptive cross-sectional study.
Setting: The Diabetic Out-patient Clinic
(DOPC), Kenyatta National Hospital
(KNH).
Subjects: Two hundred and nineteen
patients with chronic musculoskeletal
pain.
Results: The prevalence of fibromyalgia
in this group of patients was 61 (27.9%)
(95% CI 21.9-34.2). Mean age for patients
with FMS was 59.9 years, significantly
older than patients without FMS (55.6%)
(P=0.034). There was a higher female
preponderance at 49 (80%). Majority of
our study population were on followup
for Type 2 DM (94.1%). The mean
tender-point count for patients with FMS
was estimated at 13.7 (SD 2.1). The mean
FIQR score was 51.9 (SD 18.4) (moderate
disease). Patients with FMS had a higher
HBA1c value compared to those without
(9.6% vs. 9.3%) (P=0.565). Other
factors such as marital status, nature of
employment, activities of daily living and
type of medications used were not found
to be statistically significant. (P˃0.05).
Conclusion: FMS is a prevalent disease in
the diabetic population. There is increased
need of awareness by the clinicians of
this disease entity and a multidisciplinary
approach required to manage patients
presenting with CWP in DM.
Introduction
FMS is a common disorder with cardinal
symptoms of diffuse chronic pain associated
with muscle stifness and tenderness of
specific points on examination. This
disease has strong biologic underpinnings
and the aetiopathogenesis is variable.
Trigger factors may be environmental
or psychosocial. This condition affects
mainly women, and its estimated
prevalence in various populations varies
between 0.2% and 4.4%. The American
College of Rheumatology Criteria (ACR)
1990 requires CWP for at least 3 months
and presence of ˃11/18 pre-specified
Tender Points (TP) on examination1
.   
  A newer diagnostic criteria published
in 2010-2011, no longer requires
performing a tender point count to make
the diagnoses and instead entails asking
about the constellation of non-pain
somatic symptoms that are typically
present in addition to the widespread
pain2
. DM affects connective tissue in
multiple ways and this may be as a result
of micro or macrovascular complications,
a consequence of metabolic derangements
inherent to DM, and notable associations,
FMS being a key presentation3
. Over
the past few years, the most important
predictor that predisposed to development
of musculoskeletal complications is
blood glucose control. The HUNT
study4
outlined the association between
DM and chronic musculoskeletal
complaints in 64,785 patients and noted
a high prevalence of FMS and a positive
correlation with HbA1c levels. Attar5
,
revealed that up to 17.9% of diabetics
suffer from chronic musculoskeletal
manifestations, fibromyalgia being one
of them. Yunus6
, in his review article, in
2011, noted that Central Sensitization
Syndromes (CSS) have an increased
prevalence in patients with diabetes
mellitus. Of particular interest, a study

Osiro OA, Kariuki DK, Gathece LW. "Properties of clinker and alkaline-activated aluminosilicates for experimental cements.". In: IADR AMER. Addis Ababa, Ethiopia; 2017.
AI K, Gachago MM, LO N, JM N. The Quality Of Life Of Primary Caregivers Of Children With Retinoblastoma At Kenyatta National Hospital. Nairobi: University of Nairobi; 2017.
Gharial J, Laving A, Were F. "Racecadotril for the treatment of severe acute watery diarrhoea in children admitted to a tertiary hospital in Kenya." BMJ Open Gastroenterol. 2017;4(1). AbstractWebsite

Background

Diarrhoea is the second most common cause of death in children under 5 years of age in Kenya. It is usually treated with oral rehydration, zinc and continued feeding. Racecadotril has been in use for over 2 decades; however, there is a paucity of data regarding its efficacy from Africa.
Objectives

The objectives of this study were: to compare the number of stools in the first 48 hours in children with severe gastroenteritis requiring admission and treated with either racecadotril or placebo, to study the impact of racecadotril on duration of inpatient stay as well as duration of diarrhoea and to describe the side effect profile of racecadotril.
Methods

This was a randomised, double-blinded, placebo-controlled trial. It enrolled children between the age of 3 and 60 months who were admitted with severe acute gastroenteritis. They received either racecadotril or placebo in addition to oral rehydration solution (ORS) and zinc and were followed up daily.
Results

120 children were enrolled into the study. There were no differences in the demographics or outcomes between the 2 groups. Stools at 48 hours: median (IQR) of 5 (3–7) and 5 (2.5–7.5), respectively; p=0.63. The duration of inpatient stay: median (IQR): 4 days (1.5–6.5) and 4.5 (1.8–6.3); p=0.71. The duration of illness: 3 days (2–4) and 2 days (1–3); p=0.77. The relative risk of a severe adverse event was 3-fold higher in the drug group but was not statistically significant (95% CI 0.63 to 14.7); p=0.16.
Conclusions

Racecadotril has no impact on the number of stools at 48 hours, the duration of hospital stay or the duration of diarrhoea in children admitted with severe gastroenteritis and managed with ORS and zinc

Gichuhi JM, Ndegwa PN, Mugo HM, Guandaru EK, Babin R. "Rearing method and developmental biology of the African coffee white stem borer, Monochamus leuconotus (Coleoptera: Cerambycidae)." Journal of Economic Entomology. 2017;110(3):1120-1126.
Nanyingi Mark O., Muchemi GM, Samuel M. Thumbi, Ade F, Clayton O. Onyango, G.Kiama S, Bett B. "Seroepidemiological Survey of Rift Valley Fever Virus in Ruminants in Garissa, Kenya Vector-Borne and Zoonotic Diseases, Volume 17, Number 2, 2017.". 2017.
Kimuyu DM, Sensenig RL, Chira RM, GITHAIGA JOHNM, Young TP. "Spatial scales influence long-term response of herbivores to prescribed burning in a savanna ecosystem." International Journal of Wildland Fire. 2017;26(4):287-295.
Garba DGW, Oyieke FAO, EA M, LC, GS, Houmsou, RS, Darda, F, Chintem. "Species Diversity and Relative Abundance of Anopheline Vectors of Malaria on the Highlands of Mambilla Plateau Northeast, Nigeria." Journal of Biotechnology and Bioengineering. 2017;1(1):PP 37-42.speciesdiversityandrelativeabundanceofanopheline-liatuetal_2.pdf
Gichure, J. N. KMICNPM. "Standardization of cut size and pre-drying time of beef to mainstream pastoral processing in Kenya’s meat industry." Pastoralism: Research, Policy and Practice. 2017;7:1-7.
Mwaniki JM, Ogutu H, Gituauki K. "A study of Elemental composition of Biomass fuel from Kenyan grown Chamomile flowers extract." Kenya Chemical Society. 2017;10(1):14-23.
Scott AA, Misiani H, Okoth J, Jordan A, Gohlke J, Ouma G, Arrighi J, Zaitchik BF, Jjemba E, Verjee S, Waugh DW. "Temperature and Heat in Informal Settlements in Nairobi." PloS one. 2017;12(11). AbstractPLOS One

Nairobi, Kenya exhibits a wide variety of micro-climates and heterogeneous surfaces. Paved roads and high-rise buildings interspersed with low vegetation typify the central business district, while large neighborhoods of informal settlements or “slums” are characterized by dense, tin housing, little vegetation, and limited access to public utilities and services. To investigate how heat varies within Nairobi, we deployed a high density observation network in 2015/2016 to examine summertime temperature and humidity. We show how temperature, humidity and heat index differ in several informal settlements, including in Kibera, the largest slum neighborhood in Africa, and find that temperature and a thermal comfort index known colloquially as the heat index regularly exceed measurements at the Dagoretti observation station by several degrees Celsius. These temperatures are within the range of temperatures previously associated with mortality increases of several percent in youth and elderly populations in informal settlements. We relate these changes to surface properties
such as satellite-derived albedo, vegetation indices, and elevation.

Karimurio J, Rono H, Njomo D, Sironka J, Kareko C, Gichangi M, Barasa E, A M, Kefa R, Kiio F. "Use of validated community-based trachoma trichiasis (TT) case finders to measure the total backlog and detect when elimination threshold is achieved: a TT methodology paper." Pan Afr Med J. 2017;27:18.
Gathara D, Malla L, Ayieko P, Karuri S, Nyamai R, Grace Irimu, R W Nduati. "Variation in and risk factors for paediatric inpatient all-cause mortality in a low income setting: data from an emerging clinical information network." BMC Pediatrics. 2017. AbstractWebsite

BACKGROUND Hospital mortality data can inform planning for health interventions and may help optimize resource allocation if they are reliable and appropriately interpreted. However such data are often not available in low income countries including Kenya. METHODS Data from the Clinical Information Network covering 12 county hospitals' paediatric admissions aged 2-59 months for the periods September 2013 to March 2015 were used to describe mortality across differing contexts and to explore whether simple clinical characteristics used to classify severity of illness in common treatment guidelines are consistently associated with inpatient mortality. Regression models accounting for hospital identity and malaria prevalence (low or high) were used. Multiple imputation for missing data was based on a missing at random assumption with sensitivity analyses based on pattern mixture missing not at random assumptions. RESULTS The overall cluster adjusted crude mortality rate across hospitals was 6 · 2% with an almost 5 fold variation across sites (95% CI 4 · 9 to 7 · 8; range 2 · 1% - 11 · 0%). Hospital identity was significantly associated with mortality. Clinical features included in guidelines for common diseases to assess severity of illness were consistently associated with mortality in multivariable analyses (AROC =0 · 86). CONCLUSION All-cause mortality is highly variable across hospitals and associated with clinical risk factors identified in disease specific guidelines. A panel of these clinical features may provide a basic common data framework as part of improved health information systems to support evaluations of quality and outcomes of care at scale and inform health system strengthening efforts.

English M, Ayieko P, Nyamai R, Were F, Githanga D, Grace Irimu, R W Nduati. "What do we think we are doing? How might a clinical information network be promoting implementation of recommended paediatric care practices in Kenyan hospitals?" Health Res Policy Syst.. 2017;15(4). AbstractWebsite

Background

The creation of a clinical network was proposed as a means to promote implementation of a set of recommended clinical practices targeting inpatient paediatric care in Kenya. The rationale for selecting a network as a strategy has been previously described. Here, we aim to describe network activities actually conducted over its first 2.5 years, deconstruct its implementation into specific components and provide our ‘insider’ interpretation of how the network is functioning as an intervention.
Methods

We articulate key activities that together have constituted network processes over 2.5 years and then utilise a recently published typology of implementation components to give greater granularity to this description from the perspective of those delivering the intervention. Using the Behaviour Change Wheel we then suggest how the network may operate to achieve change and offer examples of change before making an effort to synthesise our understanding in the form of a realist context–mechanism–outcome configuration.
Results

We suggest our network is likely to comprise 22 from a total of 73 identifiable intervention components, of which 12 and 10 we consider major and minor components, respectively. At the policy level, we employed clinical guidelines, marketing and communication strategies with intervention characteristics operating through incentivisation, persuasion, education, enablement, modelling and environmental restructuring. These might influence behaviours by enhancing psychological capability, creating social opportunity and increasing motivation largely through a reflective pathway.
Conclusions

We previously proposed a clinical network as a solution to challenges implementing recommended practices in Kenyan hospitals based on our understanding of theory and context. Here, we report how we have enacted what was proposed and use a recent typology to deconstruct the intervention into its elements and articulate how we think the network may produce change. We offer a more generalised statement of our theory of change in a context–mechanism–outcome configuration. We hope this will complement a planned independent evaluation of ‘how things work’, will help others interpret results of change reported more formally in the future and encourage others to consider further examination of networks as means to scale up improvement practices in health in lower income countries.

Gikonyo J, Kibegwa F, Inyangala B. "Comparative assessment of hatching rates of African Catfish (Clarias gariepinus) eggs using Nile cabbage and kaka bans substrates." Livestock Research for Rural Development. 2017;29. Abstract
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Mburu CW, Gaita SM, Knee CS, GATARI MJ,... "Influence of Yttrium Concentration on Local Structure in BaZr1–xYxO3−δ Based Proton Conductors." The Journal of …. 2017. AbstractWebsite

The evolution of local structure, coordination of protons, and proton conductivity in yttrium-doped barium zirconate, BaZr1–x Y x O3− δ (x= 0–0.5), has been investigated using thermal-gravimetric analysis, impedance spectroscopy, and infrared spectroscopy. Low-frequency …

Okumu MO, Ochola FO, Mbaria JM, Kanja LW, Gakuya DW, Kinyua AW, Okumu PO, Kiama SG. "Mitigative effects of Moringa oleifera against liver injury induced by artesunate-amodiaquine antimalarial combination in wistar rats." Clinical Phytoscience. 2017;3:18. Abstract
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Gitari A, Nguhiu J, Varma V, Mogoa E. "Occurrence, treatment protocols, and outcomes of colic in horses within Nairobi County, Kenya." Veterinary World. 2017;10:1255-1263. Abstract
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Liu Y, Gureya D, Al-Shishtawy A, Vlassov V. "OnlineElastMan: self-trained proactive elasticity manager for cloud-based storage services." Cluster Computing. 2017:1-18. AbstractWebsite

The pay-as-you-go pricing model and the illusion of unlimited resources in the Cloud initiate the idea to provision services elastically. Elastic provisioning of services allocates/de-allocates resources dynamically in response to the changes of the workload. It minimizes the service provisioning cost while maintaining the desired service level objectives (SLOs). Model-predictive control is often used in building such elasticity controllers that dynamically provision resources. However, they need to be trained, either online or offline, before making accurate scaling decisions. The training process involves tedious and significant amount of work as well as some expertise, especially when the model has many dimensions and the training granularity is fine, which is proved to be essential in order to build an accurate elasticity controller. In this paper, we present OnlineElastMan, which is a self-trained proactive elasticity manager for cloud-based storage services. It automatically evolves itself while serving the workload. Experiments using OnlineElastMan with Cassandra indicate that OnlineElastMan continuously improves its provision accuracy, i.e., minimizing provisioning cost and SLO violations, under various workload patterns.

Mukaria SM, Wahome RG, Gatari M,... "Particulate Matter from Motor Vehicles in Nairobi Road Junctions Kenya." Journal of Atmospheric …. 2017. AbstractWebsite

Motor air pollution has become a problematic issue both within as it contributes to environmental degradation. It is evident that air crises in cities continue to rise partly because of the increasing levels of motor vehicle emissions. With the expansion of the …

Kibegwa F, Githui K, Joseph Jung'a, Jung'a J. {Mitochondrial DNA Diversity and Phylogenetic Relationships: Among two indigenous Kenyan goat breeds}. LAP LAMBERT Academic Publishing; 2017. Abstract
n/a
2016
Liu Y, Gureya D, Al-Shishtawy A, Vlassov V. "OnlineElastMan: Self-Trained Proactive Elasticity Manager for Cloud-Based Storage Services.". In: 2016 International Conference on Cloud and Autonomic Computing (ICCAC). Augsburg, Germany; 2016:. Abstract

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Dimba, Njiru W, Gathece LW, Mutave RJ, Ogwell A. "Tobacco cessation through use of oral health care providers in Kenya.". In: Global Tobacco Treatment Summit . Mayo Clinic Nicotine Dependence ; 2016.
GN M, RA N, MG K. "Championing radiation safety in Africa: The AFROSAFE campaign.". In: The International Pediatric Radiology 7th Conjoint Meeting and Exhibition. Chicago, Illinois, USA; 2016.
K.Muriithi M, G.Mutegi R, Mwabu G. "Impact of Educational Policies on Access to Education in Kenya.". In: NTA Meetings. Dakar, Senegal; 2016.
Oyoo GO, Genga EK, Otieno CF, Ilovi CS, Omondi EA, Otieno FO. "Clinical and socio-demographic profile of patients on treatment for osteoporosis in Nairobi, Kenya." East African Orthopaedic Journal. 2016;9(2). Abstract

Background: Osteoporosis is a chronic, progressive disease of multifactorial aetiology and one of the most common metabolic bone diseases worldwide. There is a paucity of data on osteoporosis in Africa as it’s generally thought not to affect the non-Caucasian population. We sought to describe the population with osteoporosis in a Nairobi rheumatology clinic.

Objective: To evaluate the clinical characteristics of patients with osteoporosis seen at a rheumatology clinic in Nairobi.

Methods: Clinical, with emphasis on musculoskeletal manifestations, treatment and selected comorbidities in 56 patients diagnosed with osteoporosis were followed up and evaluated in the Nairobi Arthritis Clinic.

Results: The age distribution was 31- 95 years with majority being above the age of 60 years at 71.5%. Majority were female (89.3%). The main musculoskeletal manifestations were polyarthralgia (30.4%) followed by lower back pain (19.6%) and pathological fractures (12.5%). The types of osteoporosis were grouped as primary (9%), secondary (44.6%) and post-menopausal (46.4%). The most common clinical association being rheumatoid arthritis (39.3%) followed by steroids therapy (25%). Other comorbidities included osteoarthritis, fibromyalgia, systemic lupus erythromatosus and diabetes. Seven study participants had history of fracture with lumbar spine fractures leading at 42.8%. None of the study participants were smokers. The number of patients on calcium supplements was at 71.4% and bisphosphonates was low at 32%.

Conclusion: The findings of this study from age to comorbidities on osteoporosis are in keeping with literature. The number of patients on bisphosphonates was low which differed from Western literature. Persons at increased risk for osteoporosis in this set-up include post-menopausal women with debilitating chronic illness causing reduced mobilization over time and presenting with bone pains.These patients should be investigated for osteoporosis and effective treatment administered early.

Keywords: Osteoporosis, Clinical profile, Nairobi, Kenya

WAMBUI MBOTEBETH, Opere A, Gathiga JM, Karanja FK. ASSESSING THE IMPACTS OF CLIMATE VARIABILITY AND CLIMATE CHANGE ON BIODIVERSITY IN LAKE NAKURU, KENYA. Nairobi: University of Nairobi; 2016. AbstractDepartment of Meteorology

Hydrological systems are potentially very sensitive to changes in climate. Recently, attention has been mainly drawn to the rising global temperatures; however, over the past century, human livelihoods have substantially been directly affected by changes in the regional hydrological balance. Lake Nakuru is one example of a hydrological system which has seen its water levels increasing since September 2010 during the beginning of the short rains making it the first lake in the Rift Valley bursting its banks, leading to decreased electrical conductivity levels as a result of water dilution. All flamingos left the lake, initially settling in the Lake Oloidien a small alkaline lake south of Lake Naivasha and Lake Bogoria. The increased water levels led to change in aquatic life and biodiversity, including submersion of habitats adjoining the lake and have therefore had major ecological implications on the lake and its environs.
This study, therefore, assesses the impacts of the increased water levels and the flooding of Lake Nakuru and its surrounding areas on biodiversity, specifically, the phytoplankton and lesser flamingo communities, owing to climate change and climate variability. The study focused on reviewing and analysing observed climatic records from 2000 to 2014, obtained from the Kenya Meteorological Department, especially temperature, precipitation and evaporation of Lake Nakuru in order to assess how climate variability and climate change has contributed to the increased lake levels, monitoring and reviewing information on the state of past and present records of the lesser flamingo and phytoplankton communities of Lake Nakuru was undertaken, with the data sets obtained from the Kenya Wildlife Service and National Museums of Kenya database. Several methods were employed in order to determine the past and current trends of climatic parameters (temperature, precipitation and evaporation), and also for the physicochemical characteristics of Lake Nakuru (conductivity, phytoplankton, lesser flamingos and the lake depth). These included time series analysis, trend analysis and the Pearson's correlation analysis was used to correlate the changes in lake conductivity to changes in population estimates of the lesser flamingos and the phytoplankton. Data set extracted from the Coupled Model lntercomparison Project Phase 5 (CM1P5) (IPCC Fifth Assessment Report (AR5) Atlas subset) models were subjected to time series analysis method where the future climate scenarios of near surface temperature, precipitation and evaporation were plotted for the period 2017 to 2100 (projection) for RCP2.6 and RCP8.5 relative to the baseline period 1971 to 2000 in Lake Nakuru were analysed. The results were used to assess the impact of climate change on the lesser flamingos and phytoplankton abundance.
It was observed that there was an increase in the mean annual precipitation during the study period (2009 to 2014) which caused the increase in the lake's surface area from a low area of 31.8 km2 in January 2010 to a high of 54.7 km2 in Sept 2013, indicating an increase of 22.9 km2 (71.92% surface area increase). Mean conductivity of the lake also decreased leading to the loss of phytoplankton on which flamingos feed causing them to migrate. A strong positive correlation between conductivity and the lesser flamingo population was observed implying that low conductivity affects the growth of phytoplankton and since the lesser flamingos depend on the phytoplankton for their feed, this subsequently demonstrated th&t the phytoplankton density could be a significant predictor of the lesser flamingo occurrence in Lake Nakuru. There was also a strong positive correlation observed between phytoplankton and the lesser flamingo population which confirms that feed availability is a key determining factor of the lesser flamingo distribution in the lake.
It is projected that there would be an increase in temperatures, precipitation and evaporation for the period 20 I 7 to 2100 under RCP2.6 and RCP8.5 relative to the baseline period 1971 to 2000 obtained from the Coupled Model Intercomparison Project phase 5 (CMIP5) multi-model ensemble. As a result, it is expected that the lake will further increase in surface area and depth by the year 2 I 00 due to increased precipitation thereby affecting the populations of the lesser . flamingos and phytoplankton, as the physicochemical factors of the lake will change as wel I during the projected period.
Recommendation.s that can be taken to contribute to the country's biodiversity resources, specifically in Lake Nakuru through climate change mitigation and appropriate adaptations have been provided. They include: In order to assess the variability in climate, continuous monitoring and analysing meteorological parameters in the lake basin is suggested; government policy on illegal water abstractions and massive afforestation of indigenous trees need to be enforced in order to enhance precipitation regularity so as to sustainably utilize and manage Lake Nakuru 's waters; Climate vulnerability assessments need to be carried out in order to come up with mitigations and adaptations measures unique to Lake Nakuru basin to inform the measures that need to be taken in order to minimize the negative impacts of climate vulnerability/change, and exploit the beneficial ones.

Rustagi AS, Gimbel S, Ruth Nduati, de Cuembelo MF, Wasserheit JN, Farquhar C, Gloyd S, Sherr K. "Health facility factors and quality of services to prevent mother-to-child HIV transmission in Côte d'Ivoire, Kenya, and Mozambique." Int J STD AIDS. 2016. Abstract

This study aimed to identify facility-level characteristics associated with prevention of mother-to-child HIV transmission service quality. This cross-sectional study sampled 60 health facilities in Mozambique, Côte d'Ivoire, and Kenya (20 per country). Performance score - the proportion of pregnant women tested for HIV in first antenatal care visit, multiplied by the proportion of HIV-positive pregnant women who received appropriate antiretroviral medications - was calculated for each facility using routine data from 2012 to 2013. Facility characteristics were ascertained during on-site visits, including workload. Associations between facility characteristics and performance were quantified using generalized linear models with robust standard errors, adjusting for country. Over six months, facilities saw 38,611 first antenatal care visits in total. On-site CD4 testing, Pima CD4 machine, air conditioning, and low or high (but not mid-level) patient volume were each associated with higher performance scores. Each additional first antenatal care visit per nurse per month was associated with a 4% (95% confidence interval: 1%-6%) decline in the odds that an HIV-positive pregnant woman would receive both HIV testing and antiretroviral medications. Physician workload was only modestly associated with performance. Investments in infrastructure and human resources - particularly nurses - may be critical to improve prevent mother-to-child HIV transmission service delivery and protect infants from HIV.

Bergin P, Langat R, Omosa-Manyonyi G, Farah B, Ouattara G, Park H, Coutinho H, Laufer D, Fast P, Verlinde C, Bizimana J, Umviligihozo G, Nyombayire J, Ingabire R, Kuldanek K, Cox J, McMorrow M, Fidler S, Karita E, Gilmour J, Anzala O. "Assessment of anti-HIV-1 antibodies in Oral and Nasal Compartments of Volunteers from Three different Populations." J. Acquir. Immune Defic. Syndr.. 2016. Abstract

In this study, we assessed the feasibility of collecting standardized nasal and salivary samples at centers in Nairobi (Kenya), Kigali (Rwanda) and London (UK) using different collection devices and media (Synthetic absorptive matrices versus flocked swabs, and Salimetrics Oral swabs versus whole oral fluid collection). We detected anti Gag (p24) and envelope (gp140) antibodies in both nasal fluid and salivary collections from all HIV-infected individuals, and cross-reactive anti-p24 antibodies were detected in 10% of HIV-uninfected individuals enrolled at one site. Collections from the nasal turbinates were comparable to samples collected deeper in the nasopharyngeal tract, and the yield of anti-p24 IgA in the whole oral fluid samples was higher than in samples collected from the parotid gland. We noted a trend toward reduced levels of anti-HIV antibody in the volunteers receiving anti-retroviral therapy (ART). Levels of antibodies were stable over multiple collection visits. Overall, this study shows that nasal and salivary samples can be collected in a standardized manner over repeated visits in both low and high resource settings. These methods may be used in support of future HIV vaccine clinical trials.

MacLeod DT, Choi NM, Briney B, Garces F, Ver LS, Landais E, Murrell B, Wrin T, Kilembe W, Liang C-H, Ramos A, Bian CB, Wickramasinghe L, Kong L, Eren K, Wu C-Y, Wong C-H, Kosakovsky Pond SL, Wilson IA, Burton DR, Poignard P. "Early Antibody Lineage Diversification and Independent Limb Maturation Lead to Broad HIV-1 Neutralization Targeting the Env High-Mannose Patch." Immunity. 2016;44(5):1215-26. Abstract

The high-mannose patch on HIV Env is a preferred target for broadly neutralizing antibodies (bnAbs), but to date, no vaccination regimen has elicited bnAbs against this region. Here, we present the development of a bnAb lineage targeting the high-mannose patch in an HIV-1 subtype-C-infected donor from sub-Saharan Africa. The Abs first acquired autologous neutralization, then gradually matured to achieve breadth. One Ab neutralized >47% of HIV-1 strains with only ∼11% somatic hypermutation and no insertions or deletions. By sequencing autologous env, we determined key residues that triggered the lineage and participated in Ab-Env coevolution. Next-generation sequencing of the Ab repertoire showed an early expansive diversification of the lineage followed by independent maturation of individual limbs, several of them developing notable breadth and potency. Overall, the findings are encouraging from a vaccine standpoint and suggest immunization strategies mimicking the evolution of the entire high-mannose patch and promoting maturation of multiple diverse Ab pathways.

Nduati EW, Nkumama IN, Gambo FK, Muema DM, Knight MG, Hassan AS, Jahangir MN, Etyang TJ, Berkley JA, Urban BC. "HIV-exposed uninfected infants show robust memory B cell responses in spite of a delayed accumulation of memory B cells: An observational study in the first two years of life." Clin. Vaccine Immunol.. 2016. Abstract

Improved HIV care has led to an increase in the number of HIV-exposed uninfected (HEU) infants born to HIV infected women. Although uninfected, these infants experience increased morbidity and mortality. One explanation may be that their developing immune system is altered by HIV-exposure predisposing them to increased post-natal infections.

Baden LR, Karita E, Mutua G, Bekker L-G, Glenda Gray, Hoosen M. Coovadia, Page-Shipp L, Walsh SR, Nyombayire J, Anzala O, Roux S, Laher F, Innes C, Seaman MS, Cohen YZ, Peter L, Frahm N, McElrath JM, Hayes P, Swann E, Grunenberg N, Grazia-Pau M, Weijtens M, Sadoff J, Dally L, Lombardo A, Gilmour J, Cox J, Dolin R, Fast P, Barouch DH, Laufer DS. "Assessment of the Safety and Immunogenicity of 2 Novel Vaccine Platforms for HIV-1 Prevention: A Randomized Trial." Ann. Intern. Med.. 2016;164(5):313-22. Abstract

A prophylactic HIV-1 vaccine is a global health priority.

Odeny BM, Pfeiffer J, Farquhar C, Igonya EK, Gatuguta A, Kagwaini F, Ruth Nduati, Kiarie J, Bosire R. "The Stigma of Exclusive Breastfeeding Among Both HIV-Positive and HIV-Negative Women in Nairobi, Kenya." Breastfeed Med. 2016;11:252-8. Abstract

Exclusive breastfeeding (EBF) means giving only breast milk to an infant. Although it is the optimal mode of feeding for infants younger than 6 months, its prevalence is low in HIV-endemic regions. Extensive promotion of EBF for 6 months in prevention of mother-to-child HIV transmission (PMTCT) programs could inadvertently result in stigma due to women's perceived association of EBF with HIV infection. In this qualitative study, we describe how stigma impacts the uptake of EBF among HIV-positive and -negative women.

Rustagi AS, Gimbel S, Ruth Nduati, de Cuembelo MF, Wasserheit JN, Farquhar C, Gloyd S, Sherr K. "Implementation and Operational Research: Impact of a Systems Engineering Intervention on PMTCT Service Delivery in Côte d'Ivoire, Kenya, Mozambique: A Cluster Randomized Trial." J. Acquir. Immune Defic. Syndr.. 2016;72(3):e68-76. Abstract

Efficacious interventions to prevent mother-to-child HIV transmission (PMTCT) have not translated well into effective programs. Previous studies of systems engineering applications to PMTCT lacked comparison groups or randomization.

JOSHI MD, Oesterling BM, Wu C, Gwizdz N, Pais G, Briyal S, Gulati A. "Evaluation of liposomal nanocarriers loaded with ETB receptor agonist, IRL-1620, using cell-based assays." Neuroscience. 2016;312:141-52. Abstract

One common feature of most neurodegenerative diseases, including Alzheimer's disease (AD) and stroke, is the death of neuronal cells. Neuronal cell death is associated with apoptosis, generation of reactive oxygen species and oxidative stress. Neuronal cell death pathways can be reversed by endothelin B receptor agonist, IRL-1620, which was found to enhance neuroprotection by promoting vascular and neuronal growth in a rodent stroke model. Previous studies conducted at our institution indicated that the treatment with IRL-1620 significantly improved neurological and motor function while reducing oxidative stress and overall infarct area. IRL-1620 is a hydrophilic, 15 amino acid peptide and has a molecular weight of 1820Da. In this study, we have encapsulated IRL-1620 in PEGylated liposomes in order to enhance its efficacy. Each batch of liposomes encapsulating IRL-1620 was evaluated for particle size, polydispersity index, and charge (zeta potential) over a period of time to determine their stability. A dose-response bar graph was plotted based on the effect of neuroprotection by free IRL-1620 on differentiated neuronal PC-12 cells. The 1nM concentration was found to have the highest cell viability. The liposomes loaded with IRL-1620 were tested on differentiated neuronal PC-12 cells for their neuroprotective ability against apoptosis caused by removal of nerve growth factor (NGF) against free (non-encapsulated) IRL-1620. The liposomal IRL-1620 was found to proliferate the growth of serum-deprived differentiated PC-12 cells significantly (p<0.0001). In the western blot analysis, the expression of the anti-apoptotic marker, BCL-2 was found to be increased, and that of pro-apoptotic marker, BAX was found to be decreased with liposomal IRL-1620. The effects were found to be independent of the NGF levels. Finally the free IRL-1620 was found to cause neuronal outgrowth equivalent to the 75ng/ml NGF treatment.

Landais E, Huang X, Havenar-Daughton C, Murrell B, Price MA, Wickramasinghe L, Ramos A, Bian CB, Simek M, Allen S, Karita E, Kilembe W, Lakhi S, Inambao M, Kamali A, Sanders EJ, Anzala O, Edward V, Bekker L-G, Tang J, Gilmour J, Kosakovsky-Pond SL, Phung P, Wrin T, Crotty S, Godzik A, Poignard P. "Broadly Neutralizing Antibody Responses in a Large Longitudinal Sub-Saharan HIV Primary Infection Cohort." PLoS Pathog.. 2016;12(1):e1005369. Abstract

Broadly neutralizing antibodies (bnAbs) are thought to be a critical component of a protective HIV vaccine. However, designing vaccines immunogens able to elicit bnAbs has proven unsuccessful to date. Understanding the correlates and immunological mechanisms leading to the development of bnAb responses during natural HIV infection is thus critical to the design of a protective vaccine. The IAVI Protocol C program investigates a large longitudinal cohort of primary HIV-1 infection in Eastern and South Africa. Development of neutralization was evaluated in 439 donors using a 6 cross-clade pseudo-virus panel predictive of neutralization breadth on larger panels. About 15% of individuals developed bnAb responses, essentially between year 2 and year 4 of infection. Statistical analyses revealed no influence of gender, age or geographical origin on the development of neutralization breadth. However, cross-clade neutralization strongly correlated with high viral load as well as with low CD4 T cell counts, subtype-C infection and HLA-A*03(-) genotype. A correlation with high overall plasma IgG levels and anti-Env IgG binding titers was also found. The latter appeared not associated with higher affinity, suggesting a greater diversity of the anti-Env responses in broad neutralizers. Broadly neutralizing activity targeting glycan-dependent epitopes, largely the N332-glycan epitope region, was detected in nearly half of the broad neutralizers while CD4bs and gp41-MPER bnAb responses were only detected in very few individuals. Together the findings suggest that both viral and host factors are critical for the development of bnAbs and that the HIV Env N332-glycan supersite may be a favorable target for vaccine design.

Gichuhi S, Macharia E, Kabiru J, Zindamoyen AM'bongo, Rono H, Ollando E, Wachira J, Munene R, Onyuma T, Jaoko WG, Sagoo MS, Weiss HA, Burton MJ. "Risk factors for ocular surface squamous neoplasia in Kenya: a case-control study." Trop. Med. Int. Health. 2016;21(12):1522-1530. AbstractWebsite

OBJECTIVE:
To determine modifiable risk factors of ocular surface squamous neoplasia (OSSN) in Kenya using disease-free controls.

METHODS:
Adults with conjunctival lesions were recruited at four eye care centres in Kenya and underwent excision biopsy. An equal number of controls having surgery for conditions not affecting the conjunctiva and unrelated to ultraviolet light were group-matched to cases by age group, sex and eye care centre. Associations of risk factors with OSSN were evaluated using multivariable logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs). Continuous variables were compared using the t-test or the Wilcoxon-Mann-Whitney U-test depending on their distribution.

RESULTS:
A total of 131 cases and 131 controls were recruited. About two-thirds of participants were female, and the mean age of cases and controls was 42.1 years and 43.3 years, respectively. Risk factors for OSSN were HIV infection without antiretroviral therapy (ART) use (OR = 48.42; 95% CI: 7.73-303.31) and with ART use (OR = 19.16; 95% CI: 6.60-55.57), longer duration of exposure to the sun in the main occupation (6.9 h/day vs. 4.6 h/day, OR = 1.24; 95% CI: 1.10-1.40) and a history of allergic conjunctivitis (OR = 74.61; 95% CI: 8.08-688.91). Wearing hats was protective (OR = 0.22; 95% CI: 0.07-0.63).

CONCLUSION:
Measures to prevent and control HIV, reduce sun exposure such as wearing hats and control allergic conjunctivitis are recommended.

Aggarwal NK, Lam P, Castillo EG, Weiss MG, Diaz E, Alarcón RD, van Dijk R, Rohlof H, Ndetei DM, Scalco M, Aguilar-Gaxiola S, Bassiri K, Deshpande S, Groen S, Jadhav S, Kirmayer LJ, Paralikar V, Westermeyer J, Santos F, Vega-Dienstmaier J, Anez L, Boiler M, Nicasio AV, Lewis-Fernández R. "How Do Clinicians Prefer Cultural Competence Training? Findings from the DSM-5 Cultural Formulation Interview Field Trial." Acad Psychiatry. 2016;40(4):584-91. Abstract

This study's objective is to analyze training methods clinicians reported as most and least helpful during the DSM-5 Cultural Formulation Interview field trial, reasons why, and associations between demographic characteristics and method preferences.

English M, Grace Irimu, R W Nduati, Agweyu A, Gathara D, Oliwa J, Ayieko P, Were F, Paton C, Tunis S, Forrest CB. "Building Learning Health Systems to Accelerate Research and Improve Outcomes of Clinical Care in Low- and Middle-Income Countries." PLoS Med.. 2016;13(4):e1001991. AbstractWebsite

Mike English and colleagues argue that as efforts are made towards achieving universal health coverage it is also important to build capacity to develop regionally relevant evidence to improve healthcare.

Mayanja Y, Mukose AD, Nakubulwa S, Omosa-Manyonyi G, Kamali A, Guwatudde D. "Acceptance of Treatment of Sexually Transmitted Infections for Stable Sexual Partners by Female Sex Workers in Kampala, Uganda." PLoS ONE. 2016;11(5):e0155383. Abstract

The prevalence of sexually transmitted infections (STIs) among female sex workers (FSWs) in sub-Saharan Africa remains high. Providing treatment to the affected FSWs is a challenge, and more so to their stable sexual partners. There is scanty research information on acceptance of STI treatment for stable sexual partners by FSWs. We conducted a study to assess acceptance of STI treatment for stable sexual partners by FSWs, and to identify factors associated with acceptance.

Ochwoto M, Kimotho JH, Julius Oyugi, Okoth F, Kioko H, Mining S, Budambula NLM, Giles E, Andonov A, Songok E, Osiowy C. "Hepatitis B infection is highly prevalent among patients presenting with jaundice in Kenya." BMC Infect. Dis.. 2016;16:101. Abstract

Viral hepatitis is a major concern worldwide, with hepatitis A (HAV) and E (HEV) viruses showing sporadic outbreaks while hepatitis B (HBV) and C (HCV) viruses are associated with chronic hepatitis, cirrhosis and hepatocellular carcinoma. The present study determined the proportion, geographic distribution and molecular characterization of hepatitis viruses among patients seeking medical services at hospitals throughout Kenya.

Russ CM, Ganapathi L, Marangu D, Silverman M, Kija E, Bakeera-Kitaka S, Laving A. "Perspectives of host faculty and trainees on international visiting faculty to paediatric academic departments in East Africa." BMJ Glob Health. 2016;1(3):e000097. Abstract

Investments in faculty exchanges to build physician workforce capacity are increasing. Little attention has been paid to the expectations of host institution faculty and trainees. This prospective qualitative research study explored faculty and resident perspectives about guest faculty in paediatric departments in East Africa, asking (1) What are the benefits and challenges of hosting guest faculty, (2) What factors influence the effectiveness of faculty visits and (3) How do host institutions prepare for faculty visits?

Ngaina JN, Mutai BK, Gadain H, Muthama N. "Predictability of East African Rainfall Based on EL NINO-SOUTHERN Oscillation.". In: American Geophysical Union, Ocean Sciences Meeting 2016.; 2016. Abstract

The El Nĩno-Southern Oscillation (ENSO) is a primary mode of climate variability in East Africa (EA). Here, the predictability of EA rainfall based on ENSO is quantified based on composite analysis, correlations and contingency tables. A test for field-significance considering the properties of finiteness and interdependence was also applied to avoid correlations by chance. An analysis of Principal Components (PCs) was also carried out to evaluate the atmospheric teleconnections giving rise to the Sea Surface Temperatures (SST) correlations. El Nĩno typically leads to wetter conditions during OND and drier conditions during MAM on average. Significant correlation exists between (SST) over central Pacific (in phase), Maritime Continent (out of phase) and EA OND rainfall. The correlations of ENSO indices with rainfall are statistically significant for OND and an analysis based on contingency tables shows modest predictability. The correlation is maintained for different lags, and the common area that satisfies the criteria for statistical field significance is coincident with ENSO area. The use of ENSO indices derived from the central Pacific sea surfaces improves the predictability from OND and robust on intra-seasonal to inter-annual timescales. An ENSO-based scheme that is adapted to each season and region, and takes account of intra-seasonal to inter-annual variations can thus provide skilful rainfall predictions.

Gichuhi S, Sagoo MS. "Squamous cell carcinoma of the conjunctiva." Community Eye Health. 2016;29(95):52-53.Website
Mecha JO, Kubo EN, Nganga LW, Muiruri PN, Njagi LN, Mutisya IN, Odionyi JJ, Ilovi SC, Wambui M, Githu C, Ngethe R, Obimbo EM, Ngumi ZW. "Trends in clinical characteristics and outcomes of Pre-ART care at a large HIV clinic in Nairobi, Kenya: a retrospective cohort study." AIDS Res Ther. 2016;13:38. Abstract

The success of antiretroviral therapy in resource-scarce settings is an illustration that complex healthcare interventions can be successfully delivered even in fragile health systems. Documenting the success factors in the scale-up of HIV care and treatment in resource constrained settings will enable health systems to prepare for changing population health needs. This study describes changing demographic and clinical characteristics of adult pre-ART cohorts, and identifies predictors of pre-ART attrition at a large urban HIV clinic in Nairobi, Kenya.

Yarmoshuk AN, Gauntai A, Mwangu M, Cole D, Zarowsky C. "Resilient and responsive Global Health partnerships of East African universities in a changing world.". In: Fourth Global Symposium on Health Systems Research.; 2016.resilient_and_responsive_global_health_partnerships_of_east_african.pdf
G.M.N, P.K.O. "Advanved Manufacturing Technology and Technical Labour in Manufacturing Companies in Kenya.". In: Nairobi Innovational Week. Nairobi, Kenya; 2016.
Joyce N, Muturi S, Ngugi A, Gichure A, Kimotho S. "Interventions for Children with Hearing Disabilities in the Kenya Juvenile Justice System.". In: Interventions for Children with Hearing Disabilities in the Kenya Juvenile Justice System. ted States Int’l University EAMARC conference; 2016.interventions_for_children_with_hearing_disabilities_in_the_juvenile_system.pdf
D.W. Gakuya, G.M.Muchemi, A.G.Thaiyah, P.B.Gathura. "One health:The potential of zoonotic diseases in human,livestock and wildlife interface in Kenya.". In: Pathways Kenya 2016:integrating Human Dimensions into Fisheries and wildlife management programme. Mount Kenya Safari Park,Nanyuki,Kenya; 2016.
Akinkunle O, Stefan J, Ndetei D, Musau A, Mutiso V, Mudenge C, Ngirababyeyi A, Gasovia A, Mamah D. " A comparative study of psychotic and effective symptoms in Rwandan and Kenyan students.". 2016.
Okumu MO, Mbaria JM, Kanja LW, Gakuya DW, Kiama SG, Ochola FO, Okumu PO. "Acute toxicity of the aqueous methanolic Moringa oleifera(Lam) leaf extract on female Wistar Albino rats." International Journal of Basic Clinical Pharmacology. 2016;5(5):1-6.acute_toxicity_of_the_aqueous_methanolic_moringa_oleiferalam_leaf_extract_on_female_wistar_albino_rats.pdf
Chimoita EL, Onyango CM, Kimenju JW, Gweyi-Onyango JP. "Agricultural Extension Approaches Influencing Uptake of Improved Sorghum Technologies in Embu County, Kenya." Universal Journal of Agricultural Research. 2016;1(5):45-51.extension_approaches_enhancing_improved_sorghum_uptake.pdf
Patel JP, Karanja PK, Githiri JG, Barongo JO. "APPLICATION OF EULER DECONVOLUTION TECHNIQUE IN DETERMINING DEPTHS TO MAGNETIC STRUCTURES IN MAGADI AREA, SOUTHERN KENYA RIFT." JOURNAL OF AGRICULTURE, SCIENCE AND TECHNOLOGY. 2016;18(1). AbstractFull Text

Magadi area is located in the southern part of the Kenyan rift, an active continental rift that is part of the East African Rift system. Thermal manifestations in the form of hot springs in the northern and southern shores of Lake Magadi and high heat flows suggest geothermal potential in the area. A ground magnetic survey was carried out in the study area with the aim of locating depths to bodies with sufficient magnetic susceptibility that may represent magmatic intrusions. The magnetic data was corrected, a total intensity magnetic contour map produced and profiles drawn across identified anomalous regions. Magnetic survey data in profile form over anomalous regions was interpreted rapidly for source positions and depths by Euler deconvolution technique. Geologic constraint was imposed by use of a structural index 1.0 that best describes prismatic bodies such as intrusive dykes. The magnetic bodies were imaged at depths ranging from 0 km to about 11 km along the profiles. The imaged depths along the profiles display discontinuities in magnetic markers due to presence of numerous faults in the area. The detected magnetic bodies may be cooling dykes that heat the underground water responsible for the numerous hot springs surrounding Lake Magadi. Such a dyke is suspected to originate from a magma chamber conducting heat to the underground water. A model whereby the faults in the region provide escape of water as hot springs is proposed.

Gitau M, Omwenga EI. "Application of the UTAUT Model to understand Factors Influencing the use of Web 2.0 tools in e-learning in Kenyan Public Universities." Journal of Emerging Trends in Computing and Information Sciences. 2016;7(4):204-209. Abstractjournal_vol7no4_6_miriam_omwenga.pdfJournal website

The introduction of Web 2.0 tools has led to enhanced communication and collaboration in both social and academic environments. The focus of this study was to identify factors influencing the use of Web 2.0 tools in e-learning in Kenyan Public Universities. The tools can then be introduced and used to aid in successful collaborative learning. A descriptive survey research design was used. Data was collected through questionnaires from both students and lecturers. Purposive sampling was used for the selection and the respondents, who included e-learning instructors and students. A total of 48 lecturers and 136 students participated in the study. The results of the study showed that the most common tools used for elearning
in Kenyan Public Universities were social networks, which included YouTube and Facebook. It was also interesting to note how learners perceived the tools. The major challenges relating to these tools were also identified.
Finally, Performance expectancy was identified as the main factor influencing the use of Web 2.0 tools in Public Universities in Kenya.
Keywords: E-learning, learning management systems, unified theory of acceptance and use of technology

Aluvaala J, Nyamai R, Were F, Wasunna A, Kosgei R, Karumbi J, Gathara D, English M. "Assessment of neonatal care in clinical training facilities in Kenya." Arch Dis Child. 2016;(100):42-47. Abstractassessment_of_neonatal_care_in_clinical_training_facilities_in_kenya.pdf

Objective: An audit of neonatal care services provided by clinical training centres was undertaken to identify areas requiring improvement as part of wider efforts to improve newborn survival in Kenya.
Design: Cross-sectional study using indicators based on prior work in Kenya. Statistical analyses were descriptive with adjustment for clustering of data. Setting Neonatal units of 22 public hospitals. Patients Neonates aged <7 days.
Main outcome measures: Quality of care was assessed in terms of availability of basic resources (principally equipment and drugs) and audit of case records for documentation of patient assessment and treatment at admission.
Results: All hospitals had oxygen, 19/22 had resuscitation and phototherapy equipment, but some key resources were missing—for example kangaroo care was available in 14/22. Out of 1249 records, 56.9% (95% CI 36.2% to 77.6%) had a standard neonatal admission form. A median score of 0 out of 3 for symptoms of severe illness (IQR 0–3) and a median score of 6 out of 8 for signs of severe illness (IQR 4–7) were documented. Maternal HIV status was documented in 674/1249 (54%, 95% CI 41.9% to 66.1%) cases. Drug doses exceeded recommendations by >20% in prescriptions for penicillin (11.6%, 95% CI 3.4% to 32.8%) and gentamicin (18.5%, 95% CI 13.4% to 25%), respectively.
Conclusions: Basic resources are generally available, but there are deficiencies in key areas. Poor documentation limits the use of routine data for quality improvement. Significant opportunities exist for improvement in service delivery and adherence to guidelines in hospitals providing professional training.

Gakuubi MM, Wanzala W, Wagacha JM, Dossaji SF. "Bioactive properties of Tagetes minuta L. (Asteraceae) essential oils: A review." American Journal of Essential Oils and Natural Products. 2016;4(2):27-36. Abstract4-2-6.1_1.pdf

Mexican marigold (Tagetes minuta L.) and its accruing products have a long worldwide history of human uses such as food, therapeutics and aromatherapy which are inherent in the plant’s unique chemical composition and bioactivities. In the recent past, T. minuta essential oils (EOs) have received great attention in research, and their phytochemistry, bioactivities and uses remain the focus of considerable scientific studies. The interest in EOs is largely due to increased demand by consumers for natural-based products such as additives, drugs and pesticides, whose global acceptability and safety is highly regarded compared to synthetic products. The purpose of this review is to document the existing value addition and evidence-based multipurpose potential and considerations of T. minuta as a new generation crop as provided for by in-depth scientific studies of its EOs. Among the bioactivities and therapeutic properties attributed to T. minuta EOs include: antihelminthic, carminative, arthropod repellency, sedative, weedicidal, antiseptic, diaphoretic, spasmolytic, germicides, stomachic, antispasmodic, antiprotozoal, bactericidal, emmenagogue, nematicidal, insecticidal, fungicidal, antiviral and other microbicidal properties against a wide range of plant, human and animal pathogens, pests and parasites. Oil of T. minuta is therefore a potentially useful agent for protecting food crops on farm and in storage and livestock, thereby enhancing food security and improving human livelihoods. Nevertheless, increased value addition and the need for validation of traditionally claimed usages and applications of T. minuta EOs through in-depth scientific studies should be prioritized to globally position this plant as a new generation crop.

English M, Grace Irimu, R W Nduati, Agweyu A, Gathara D, Oliwa J, Ayieko P, Were F, Paton C, Tunis S, Forrest CB. "Building Learning Health Systems to Accelerate Research and Improve Outcomes of Clinical Care in Low- and Middle-Income Countries." PLOS Medicine. 2016;10(1371). Abstractbuilding_learning_health_systems_to_accelerate_research_and_improve_outcomes_of_clinical_care_in_low-_and_middle-income_countries.pdf

Achieving universal coverage that supports high-quality care will require that health systems are designed to integrate the delivery of health services with the generation of new knowledge about the effectiveness of these services.
System strengthening and research will need to be better integrated to achieve this in low- and middle-income countries (LMIC) so that changes in coverage, quality, and impact are measured, costs are contained, and health systems are responsive to users’ needs and concerns.
In high-income countries, learning health systems (LHS) are emerging to meet similar needs. The LHS vision aspires to engage policy makers, researchers, service providers, and patients in learning that uses and strengthens routinely collected data to conduct pragmatic, contextually appropriate research, promote rapid adoption of findings to improve quality and outcomes, and promote continuous learning.
Although there are significant challenges, we should begin to develop LHS in LMIC for their immediate and longer term benefits and to avoid having to retrofit health systems with the capability to promote learning at a later date and even greater cost.
A global coalition on how to build LHS effectively that shares accumulating learning could enable such a strategy.

Calatayud P-A, Njuguna E, Mwalusepo S, Gathara M, Okuku G, Kibe A, B M, Williamson D, Ong’amo G, Juma G, Johansson T, Subramanian S, Gatebe E, BP LR. "Can climate-driven change influence silicon assimilation by cereals and hence the distribution of lepidopteran stem borers in East Africa? ." AGRICULTURE, ECOSYSTEMS AND ENVIRONMENT. 2016;224:95-103.
Mwirigi M, Nkando I, Olum M, Attah-Poku S, Ochanda H, Berberov E, Potter A, Gerdts V, Perez-Casal J, Wesonga H, Soi R, Naessens J. "Capsular polysaccharide from Mycoplasma mycoides subsp. mycoides shows potential for protection against contagious bovine pleuropneumonia." Veterinary Immunology and Immunopathology. 2016;178:64-69. Abstract

Abstract Contagious Bovine Pleuropneumonia (CBPP) is a severe respiratory disease
caused by Mycoplasma mycoides subsp. mycoides (Mmm) which is widespread in Africa.
The capsule polysaccharide (CPS) of Mmm is one of the few identified virulence
determinants. In a previous study, immunization of mice against CPS generated antibodies,
but they were not able to prevent multiplication of Mmm in this model animal. However, mice
cannot be considered as a suitable animal model, as Mmm does not induce pathology in ...

mary g., john m., lewis n., isaac m., ambrose v. "The challenges facing adult and continuing education in Kenya. ." International Journal of Education and Social Sciences. 2016;10(3):53-57.
Were F, Ayieko P, English M, Githanga D. "Characteristics of admissions and variations in the use of basic investigations, treatments and outcomes in Kenyan hospitals within a new Clinical Information Network ." Archives of Diseases of Childhood. 2016;101:223-229. Abstractarch_dis_child-2016-ayieko-223-9.pdf

Background Lack of detailed information about hospital activities, processes and outcomes hampers planning, performance monitoring and improvement in low-income countries (LIC). Clinical networks offer one means to advance methods for data collection and use, informing wider health system development in time, but are rare in LIC. We report baseline data from a new Clinical Information Network (CIN) in Kenya seeking to promote data-informed improvement and learning. Methods Data from 13 hospitals engaged in the Kenyan CIN between April 2014 and March 2015 were captured from medical and laboratory records. We use these data to characterise clinical care and outcomes of hospital admission. Results Data were available for a total of 30 042 children aged between 2 months and 15 years. Malaria (in five hospitals), pneumonia and diarrhoea/dehydration (all hospitals) accounted for the majority of diagnoses and comorbidity was found in 17 710 (59%) patients. Overall, 1808 deaths (6%) occurred (range per hospital 2.5%–11.1%) with 1037 deaths (57.4%) occurring by day 2 of admission (range 41%–67.8%). While malaria investigations are commonly done, clinical health workers rarely investigate for other possible causes of fever, test for blood glucose in severe illness or ascertain HIV status of admissions. Adherence to clinical guideline-recommended treatment for malaria, pneumonia, meningitis and acute severe malnutrition varied widely across hospitals. Conclusion Developing clinical networks is feasible with appropriate support. Early data demonstrate that hospital mortality remains high in Kenya, that resources to investigate severe illness are limited, that care provided and outcomes vary widely and that adoption of effective interventions remains slow. Findings suggest considerable scope for improving care within and across sites.

Gakuubi M, Wagacha J, Dossaji S, Wanzala W. "Chemical Composition and Antibacterial Activity of Essential Oils of Tagetes minuta (Asteraceae) against Selected Plant Pathogenic Bacteria." International Journal of Microbiology. 2016;2016:1-9. Abstracttagetes_2016.pdf

The objective of this study was to determine the chemical composition and antibacterial activity of essential oils (EOs) of Tagetes minuta against three phytopathogenic bacteria Pseudomonas savastanoi pv. phaseolicola, Xanthomonas axonopodis pv. phaseoli, and Xanthomonas axonopodis pv. manihotis.The essential oils were extracted using steam distillation method in a modified Clevengertype apparatus while antibacterial activity of the EOs was evaluated by disc diffusion method. Gas chromatography coupled to
mass spectrometry (GC/MS) was used for analysis of the chemical profile of the EOs. Twenty compounds corresponding to 96% of the total essential oils were identified with 70% and 30% of the identified components being monoterpenes and sesquiterpenes, respectively.The essential oils of T. minuta revealed promising antibacterial activities against the test pathogens with Pseudomonas savastanoi pv. phaseolicola being the most susceptible with mean inhibition zone diameters of 41.83 and 44.83mm after 24 and
48 hours, respectively. The minimum inhibitory concentrations and minimum bactericidal concentrations of the EOs on the test bacteria were in the ranges of 24–48mg/mL and 95–190mg/mL, respectively.These findings provide a scientific basis for the use of T. minuta essential oils as a botanical pesticide for management of phytopathogenic bacteria.

Gakuubi M, Wagacha J, Dossaji S, Wanzala W. "Chemical composition and antifungal activity of essential oils of Tagetes minuta (Asteraceae) against selected phytopathogenic fungi." American Journal of Essential Oils and Natural Products. 2016;4(3):16-26. Abstract4-3-5.1.pdfWebsite

Over the years, management of plant pathogenic fungi has primarily relied on the use of synthetic
chemical fungicides. However, in the recent past, exploration for biologically active compounds from
plants with the aim of discovery and development of novel and eco-friendly biopesticides to combat
current and emerging plant pathogenic fungi has received increased interest. This study aimed at
extraction and characterization of Tagetes minuta essential oils (EOs) as well as evaluation of their
antifungal activity against selected phytopathogenic fungi namely: Fusarium oxysporum, F. solani,
Aspergillus flavus, A. parasiticus and A. niger. Essential oils were extracted using the steam distillation
method in a modified Clevenger-type apparatus. The antifungal activity of the EOs was assessed by disc
diffusion method while gas chromatography - mass spectrometry (GC/MS) was used for characterization
of the chemical components of the EOs. Twenty compounds corresponding to 96% of the total essential
oils and constituting a mixture of monoterpenes (70%) and sesquiterpenes (30%) were identified in the
Eos. They included elixene and silphiperfol-6-ene, which are being reported for the first time in essential
oils of Tagetes minuta. The EOs of T. minuta exhibited potent antifungal activity against the studied
fungi with the highest growth inhibition observed in F. oxysporum and A. niger with mean inhibition
zones of 28.7mm after five days of incubation. Four out of the five test fungi fell within the category of
extremely sensitive (inhibition zone diameters ≥ 20mm) when subjected to the crude EOs. The minimum
inhibitory concentrations (MICs) and minimum fungicidal concentrations (MFCs) of the EOs against the
fungi were in the ranges of 24 - 95mg/mL and 24 - 190mg/mL, respectively. This study thus lays down
significant groundwork for a more comprehensive study on the practical feasibility of using T. minuta
EOs as possible alternative to synthetic fungicides in the management of economically important
phytopathogenic fungi.

Maureene Auma Ondayo, Gelas Muse Simiyu, Phillip Okoth Raburu, Were FH. "Child Exposure to Lead in the Vicinities of Informal Used Lead-Acid Battery Recycling Operations in Nairobi Slums, Kenya." Journal of Health and Pollution. 2016;6(12):15-25. Abstractwebsite to access full text

Background. Child exposure to lead from informal used lead-acid battery (ULAB) recycling operations is a serious environmental health problem, particularly in developing countries.

Objectives. We investigated child exposure to lead in the vicinities of ULAB recycling operations in the Dandora, Kariobangi and Mukuru slums in Nairobi between January and August 2015.

Methods. Top soil (n = 232) and floor dust (n = 322) samples were collected from dwelling units (n = 120) and preparatory schools (n = 44) and analyzed using an inductively coupled plasma-optical emission spectrometer at the Mines and Geological Department Laboratory in the Ministry of Mining, Nairobi. From the obtained lead levels in soil and house dust, child blood lead levels were subsequently predicted using the Integrated Exposure Uptake Biokinetic Model for Lead in Children (IEUBK), Windows version.

Results. Lead loadings in all the floor dust samples from the Dandora, Kariobangi and Mukuru slums exceeded the United States Environmental Protection Agency (USEPA) guidance value for lead on floors with a range of 65.2 – 58,194 μg/ft2. Control floor dust samples recorded lower lead loadings compared to the Dandora, Kariobangi and Mukuru slums. Lead concentration in 70.7% of the soil samples collected from waste dumps, industrial sites, residential areas, playgrounds and preparatory schools in Dandora, Kariobangi and Mukuru exceeded the respective USEPA guidance values for lead in soils. Lead concentration in 100% of control soil samples were below the respective USEPA limits. The IEUBK model predicted that nearly 99.9% of children ≤ 7 years old living near informal ULAB recycling operations in Dandora, Kariobangi and Mukuru were at risk of being lead poisoned, with predicted blood lead levels (BLL) above the Centers for Disease Control (CDC) reference value for blood lead. A total of 99.9% of exposed children living in the Mukuru slums are likely to have BLL above 34 μg/dL.

Conclusions. There is a need for coordinated efforts to decrease lead emissions from informal battery recycling in Nairobi slums and to remediate existing soils, particularly around battery workplaces and dumpsites. The BLL of local children should be clinically tested and appropriate intervention measures taken.

Keywords: soil, house dust, predicted child blood lead, used lead-acid battery recycling, Nairobi slums, IEUBK

Gawriluk, T. R., Simkin, J., Thompson, K.L., Biswas, S., Clare-Salzler, Z., Kimani, J.M., Kiama, S.G., Ezenwa V.O., Smith, M. "Comparative analysis of ear-hole closure identifies epimorphic regeneration as a discrete trait in mammals. Nat. Commun. 7:11164 doi: 10.1038/ncomms11164.". 2016.
Njogu PM, Guantai EM, Pavadai E, Chibale K. "Computer-Aided Drug Discovery Approaches against the Tropical Infectious Diseases Malaria, Tuberculosis, Trypanosomiasis, and Leishmaniasis." ACS Infectious Diseases. 2016;2:8-31. Abstract

Despite the tremendous improvement in overall global health heralded by the adoption of the Millennium Declaration in the year 2000, tropical infections remain a major health problem in the developing world. Recent estimates indicate that the major tropical infectious diseases, namely, malaria, tuberculosis, trypanosomiasis, and leishmaniasis, account for more than 2.2 million deaths and a loss of approximately 85 million disability-adjusted life years annually. The crucial role of chemotherapy in curtailing the deleterious health and economic impacts of these infections has invigorated the search for new drugs against tropical infectious diseases. The research efforts have involved increased application of computational technologies in mainstream drug discovery programs at the hit identification, hit-to-lead, and lead optimization stages. This review highlights various computer-aided drug discovery approaches that have been utilized in efforts to identify novel antimalarial, antitubercular, antitrypanosomal, and antileishmanial agents. The focus is largely on developments over the past 5 years (2010−2014).

CK M, PN K, K M, DG N, GA M, SA O. "Correlates and management of anaemia of chronic kidney disease in a Kenyan tertiary hospital. ." East African Medical Journal. 2016.

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