Solid-phase peptide syntheses of oxytocin, oxytocin analogs and interferon short chain with the amide side-chain functionality of asparagine protected with 1-tetralinyl group

Citation:
YUSUF DROKEYOAMIR. "Solid-phase peptide syntheses of oxytocin, oxytocin analogs and interferon short chain with the amide side-chain functionality of asparagine protected with 1-tetralinyl group.". In: Doctor of Philosophy in Chemistry. Journal of the Kenya Chemical Society; 1998.

Abstract:

1-Tetralone was converted to 1-aminotetralin. This amine was then used to protect the carboxamide side-chain of asparagine. Syntheses of oxytocin and its derivatives were then done via Boc-solid-phase peptide synthesis using this protected asparagine. After syntheses of the nonapeptide resins, cleavage and eventual cyclization of the hormones was done using trifluoromethane sulphonic acid at 40 degrees Celcius for two hours.

Notes:

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