Bio

Professional profile

An organic chemistry associate professor with over 27years teaching experience at university level. I have published twenty nine (29) papers in refereed journals,  supervised two (2) Ph.D. and ten(10) M.Sc. students in chemistry to completion. Three (3) Ph.D and seven (7) MSc are ongoing.

I have examined fourty (40) theses at both M.Sc. and Ph.D. level and thirty eight (38) at undergraduate level. I have attended and presented in conferences and workshops. I have written an organic chemistry book and a laboratory manual for second year undergraduate students.

Publications


2017

Birgen, J, Yusuf AO, Wafula G, Onyatta JO.  2017.  Assessment of sulphur dioxide levels in selected sites in Athi River, Kenya. International Journal of Trend in Scientific Research and Development. 1(5):416-422.scan_trend.pdf

2016

Ooko, J, Onyatta JO, Yusuf AO.  2016.  Atmospheric corrosion studies in Kenya. Past, present and future. African Corrosion Journal. 2(1):25-32.afr_cor_j_corrosion.pdf

2015

V., S, J. K, B. O, A. Y, M. K.  2015.  In-vitro anthelmintic activity of vernonia amygdalina Del. (asteraceae) roots using adult Haemonchus contortus worms. International Journal of Pharmacological Research. 5(1):1-7.vernonia_amygdalina.pdf

2014

Orata, D, Yusuf AO, Nineza C, Mbui D, Mukabi M.  2014.  Surface modified electrodes used in cyclic voltammetric profiling of quinine, as antimalarial drug. Journal of Applied Chemistry. 7(5):81-89.iosr_7_5_2_2014_quinine.pdf
Yusuf, AO, Gitu PM, Bhatt BM, Njogu M, Salim A, Orata D.  2014.  Solid-Phase Peptide Synthesis of Arginine-vasopressin With Amide Side chain of Asparagine Protected With 1-Tetralinyl Group. Journal of Chemistry & Materials Research. 6(4):60-65.cmr_spps_arg_vaso.pdf
Yusuf, A, Gitu P, Bhatt BM, Njogu M, Salim A, Orata D.  2014.  Solid-Phase Peptide Synthesis of Arginine-vasopressin With Amide Side chain of Asparagine Protected With 1-Tetralinyl Group. Journal of Chemistry & Materials Research. 6(4):60-65.
Orata, D, Yusuf AO, Nineza C, Mukabi M, D. M.  2014.  Surface Modified Electrode Used In the Electro-Analysis of N- Acetyl P-Aminophenol- A Pharmaceutical Drug . Journal of Applied Chemistry. 7(5):90-99.iosr_7_5_2_2014_acetyl.pdf
s. Derese, Barasa L, Akala HM, Yusuf A, Kamau E, Matthias H.  2014.  4'-Prenyloxyderrone from the stem bark of milletia oblata ssp. teitensis and the antiplasmodial activities of isoflavones from some miletia species. Phytochemistry Letters. 8:69-72.scan0020.pdf
Muiva, L, Macharia B, Akala H, Derese S, Omosa LK, Yusuf A, Kamau E, Koch A, Heidenreich M, Yenesew A.  2014.  6a-Hydroxy-α-toxicarol and (+)-Tephrodin with antiplasmodial activities from Tephrosia species. Phytochemistry Letters. 10:179-183.scan0062.pdf
Orata, D, Yusuf A, Nineza C, Mbui D, Mukabi M.  2014.  Surface modified electrodes used in cyclic voltammetric profiling of quinine, as antimalarial drug”. IOSR Applied Chemistry. 7(5, ver II):81-89.scan0001.pdf
Yusuf, A, Gitu P, Bhatt B, Njogu M, Salim A, Orata D.  2014.  1-Tetralinyl as carboxamide protecting group for asparagines and application to N-alpha-t-butyloxycarbonyl (Boc) solid-phase peptide synthesis of oxytocin. chemistry and materials research. 6(2):1-11.

2011

2010

Mbugua, P, Salim A, Onditi A, Yusuf A.  2010.  Determination of Micronutrients and micronutrients in Soil Samples from Around Lake Ol-Bolossat. Int. J. Biol. Sci.. 2(8):140-148.scan0016.pdf
DM, K, A S, A O, A Y.  2010.  Environmental effects of selected chemical and physical geothermometers at Olkaria Geothrmal power plant. Journal of Sustainable Development. 3(6):14-25.: International journal of Sustainable development Abstractscan0015.pdfWebsite

21) S. Derese, A. Yenesew, J.O. Midiwo, Heydenreich and M.G. Peter. (). ..

2007

Mbugua, MN, Yusuf AO, Bhatt BM, P.M. G.  2007.  CONVERSION OF VERNONIA GALAMENSIS OIL TO PYRIDINYLVERNOLAMIDES AND THEIR ANTIMICROBIAL ACTIVITIES . Bulletin of the Chemical Society of Ethiopia. 21(1):103-110.bcse_21_1_vernonia_galamensis_2007.pdf

2006

2005

SA, O, PF M, GJ S, J M, S K, GA O, HD. S.  2005.  Plasmodium falciparum: evaluation of a quantitative nucleic acid sequence-based amplification assay to predict the outcome of sulfadoxine-pyrimethamine treatment of uncomplicated malaria.. AbstractFull text link

A quantitative nucleic acid sequence-based amplification (QT-NASBA) assay was employed to predict retrospectively the outcome of sulfadoxine-pyrimethamine (SP) treatment of uncomplicated malaria in children aged <6 years in an endemic region. Blood samples were collected at initial diagnosis and during follow-up. Mutation-specific nested PCR methods to analyse DHFR (Arg-59) and DHPS (Glu-540) mutations that are associated with SP drug resistance were applied. Parasite genotyping was performed to distinguish between re-infection and recrudescence. Eighty-six patients were recruited of which 66 were available for follow-up. Nine children were classified as early treatment failure, 13 cases were classified as late clinical failure, 32 as late parasitological failure, and only 12 children had an adequate clinical and parasitological response. DHFR and DHPS mutations conferring SP resistance were abundant in the Plasmodium population. Blood samples obtained 7 days after treatment were used to predict retrospectively the outcome of SP treatment. QT-NASBA was able to give a correct prediction of treatment outcome in 85.7% of the cases. Positive predictive value (PPV) of QT-NASBA case was 95% (95% confidence interval = 88.3-100) and negative predictive value (NPV) was 63% (95% CI = 39.5-86.5). In contrast, microscopy correctly predicted outcome in only 37.5% of the cases. PPV of microscopy was 100% (95% CI = 73.9-100) and the NPV was 25.5% (95% CI = 13.0-38.0). The analysis of a day 7 blood sample with QT-NASBA allows for the prediction of late clinical or parasitological treatment failure in the majority of the cases analysed in the present study.

2004

Yusuf, A.  2004.  Organic Chemistry 2 (SCH 202). , Nairobi: University of Nairobi Pressscan0023.pdf
Yusuf, A, Bhatt B, Gitu P.  2004.  1-Tetralinyl group for asparagine side-chain protection, and application to Boc solid-phase peptide synthesis”. The Kenya Chemical Society. 2:14-18.
Yusuf, A, Bhatt B, Gitu P.  2004.  1-Tetralinyl group for asparagine side-chain protection and application to Boc- Solid-phase Peptide Synthesis of mesotocin. The Kenya Chemical Society. 2(1):14-18.: Journal of the Kenya Chemical Society Abstractscan0018.pdfWebsite

n/a

2002

2001

1998

Gitu, PM, Yusuf A, Bhatt BM.  1998.  Application of tetralinyls as carboxamide protecting groups in peptide synthesis. Bulletin of the Chemical Society of Ethiopia. 12(1):35-43.bcse_12_1_1998.pdf
Gitu, P, Yusuf A, Ogutu V.  1998.  Application of tetralinyl group in solid-phase peptide synthesis. Int. J. BioChemiPhysics. 6,7(1,2):7-10.scan0055.pdf
YUSUF, DROKEYOAMIR.  1998.  Solid-phase peptide syntheses of oxytocin, oxytocin analogs and interferon short chain with the amide side-chain functionality of asparagine protected with 1-tetralinyl group. Doctor of Philosophy in Chemistry. : Journal of the Kenya Chemical Society Abstract
1-Tetralone was converted to 1-aminotetralin. This amine was then used to protect the carboxamide side-chain of asparagine. Syntheses of oxytocin and its derivatives were then done via Boc-solid-phase peptide synthesis using this protected asparagine. After syntheses of the nonapeptide resins, cleavage and eventual cyclization of the hormones was done using trifluoromethane sulphonic acid at 40 degrees Celcius for two hours.

1993

Bhatt, B, Gitu P, Yusuf A.  1993.  Synthesis of 1-aminotetralin and its derivatives by reductive amination of their corresponding 1-tetralones". Int. J. BioChemiPhysics. 2(1,2):55-77.

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