Vangueria, infausta, root bark: in vivo and in vitro antiplasmodial activity.

Citation:
Yenesew A. "Vangueria, infausta, root bark: in vivo and in vitro antiplasmodial activity." British Journal of Biomedical Science . 2006; 63,:129-133.

Abstract:

Vangueria infausta burch subsp. infausta (Rubiaceae) produces fruits eaten by humans and animals. The leaf, fruit, stem bark and root bark are used as a remedy for many ailments and the roots are used to treat malaria. In this study, concentrations of fractions of the V. infausta root bark extract that produce 50% inhibition (IC50) are determined using the ability of the extract to inhibit the uptake of [G3H]-hypoxanthine by P. falciparum cultured in vitro. The root bark extract showed antimalarial activity against Plasmodium berghei in mice. It gave a parasite suppression of 73.5% in early infection and a repository effect of 88.7%. One fraction obtained from a chloroform extract gave an IC50 value of 3.8±1.5 μg/mL and 4.5±2.3 μg/mL against D6 and W2 strains of P. falciparum, respectively, and another from the butanol extract gave an IC50 value of 3.9±0.3 μg/mL against the D6 strain. Chloroquine had an IC50 value of 0.016 μg/mL and 0.029 μg/mL against D6 and W2 strains, respectively. The plant showed the presence of flavonoids, coumarins,
tannins, terpenoids, anthraquinones and saponins.

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