Terpurinflavone: An Antiplasmodial Flavone from The Stem of Tephrosia purpurea

Yenesew A., Juma, W.P. AEMHOGPWIHMFL. "Terpurinflavone: An Antiplasmodial Flavone from The Stem of Tephrosia purpurea." Phytochemistry Letters .. 2011;4:176-178.


The stem extract of Tephrosia purpurea showed antiplasmodial activity against the D6 (chloroquine-sensitive) and W2 (chloroquine-resistant) strains of Plasmodium falciparum with IC50 values of 10.47 ± 2.22 μg/ml and 12.06 ± 2.54 μg/ml, respectively. A new prenylated flavone, named terpurinflavone, along with the known compounds lanceolatin A, (−)-semiglabrin and lanceolatin B have been isolated from this extract. The new compound, terpurinflavone, showed the highest antiplasmodial activity with IC50 values of 3.12 ± 0.28 μM (D6) and 6.26 ± 2.66 μM (W2). The structures were determined on the basis of spectroscopic evidence.

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